CN103948975A - Targeted drug release intervened medical appliance and preparation method thereof - Google Patents
Targeted drug release intervened medical appliance and preparation method thereof Download PDFInfo
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- CN103948975A CN103948975A CN201410209648.XA CN201410209648A CN103948975A CN 103948975 A CN103948975 A CN 103948975A CN 201410209648 A CN201410209648 A CN 201410209648A CN 103948975 A CN103948975 A CN 103948975A
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Abstract
The invention provides a targeted drug release intervened medical appliance and a preparation method thereof. The medical appliance is characterized by comprising an intervening medical appliance and a sustained-release drug coating, wherein the sustained-release drug coating is applied to the surface of the intervening medical appliance. The preparation method comprises a step of applying drugs to the intervening medical appliance to form the targeted drug release intervened medical appliance, wherein the sustained-release drug coating consists of a medicinal material, a medicinal carrier material, antioxidant and adhesive, and the drug application to the intervening medical appliance sequentially comprises the following steps: (1) preparing the sustained-release drug coating; (2) applying the sustained-release drug coating; (3) drying. According to the targeted drug release intervened medical appliance, the binding strength between the sustained-release drug coating and the surface of the intervening medical appliance is high, the medicinal material is prevented from being lost in the subsequent processing process, and the targeted drug release intervened medical appliance has a good drug treatment effect.
Description
Technical field
The present invention relates to medical instruments field, be specifically related to can targeting fixed point administration, realize medicine at apparatus and preparation method thereof for intracavitary therapy of the integral structure design of targeting lesion region slow release.
Background technology
Along with the extensive use of medicine slow release stent system and the development of new technique, people are more deep to medicine slow release stent systematic research.In operation, find, in support implantable intravascular, because the expansion of the support of metal or nonmetal structure is supported, inevitably blood vessel is swiped, thereby caused damage.After surgery, needs of patients is taken anticoagulation medicine to avoid the formation of thrombosis.With respect to the bare bracket that there is no medication coat, vascular endothelial cell can heal automatically in 30 days, and patient needn't take anticoagulation medicine again, but the probability that restenosis occurs is 25 ~ 50%.And medicine (comprising rapamycin and derivant thereof, paclitaxel and derivant thereof) is although slow release stent has effectively suppressed vascellum endometrial hyperplasia, because the slow release of medicine has postponed the healing of vascular endothelial cell.Caused support to implant the potential danger that acute thrombus is lethal has occurred late period.According to relevant data, show, medicine slow release stent still has the case that acute thrombus occurs to occur after 2 years at implantable intravascular.Therefore the implantation rate of some national drug slow release stent systems (DES) of west drops to current 70% from 90% of the first two years.
So new apparatus and therapeutic strategy continue to bring out and be intended to capture this difficult problem in recent years, drug release sacculus (DEB) is one of more promising technology wherein.Medicament elution sacculus is the combination product of traditional balloon angioplasty and advanced drug release technology.In theory, sacculus is the ideal carrier of anti-proliferative drugs, medicine is pushed the effect that is released into local vessel wall and brings into play prevention of restenosis in process of expansion rapidly, uniformity, because the high local concentrations persistent period that antiproliferative effect is required is shorter, so be conducive to carrying out fast of blood vessel wall endothelialization, thereby avoid the generation of thrombosis.A kind of card that effectively supplements as stenting demonstrates its superiority gradually.
But get involved in class medical device product at the drug release of listing at present, a lot of products occur that medication coat peels off serious phenomenon in vitro in process of expansion, this can cause medicine in vivo in course of conveying, drug loss is serious, the targeting target bit dose that further has influence on coating is unstable, thereby affects therapeutic effect.This is the imperfection due to coating formula and coating process, causes existing product in the follow-up folding course of processing, and drug loss is serious, has affected the drug targeting treatment in operation.The medicine for the treatment of at present use in coating is fat-soluble medicine (paclitaxel, rapamycin and derivant thereof etc.) substantially, and as promoting that the carrier material of drug release is water soluble drug (iodixanol, Iopromide, carbamide, polyvinyl alcohol etc.), the bond strength of medicine and carrier is low, thereby caused binding strength of coating low, following process difficulty.
Summary of the invention
The object of the invention is to provide a kind of targeted drug and discharges and get involved class medical apparatus and instruments and preparation method thereof, has solved under technique at present ubiquity medication coat and to get involved class medical apparatus surface adhesion strength low, thereby affects a difficult problem for apparatus medication effect.
For achieving the above object, a kind of targeted drug that the present invention adopts discharges the technical scheme that gets involved class medical apparatus and instruments: described targeted drug discharges gets involved class medical apparatus and instruments by getting involved class medical apparatus and instruments and slow releasing pharmaceutical coating forms, and slow releasing pharmaceutical coating is on the surface of described intervention class medical apparatus and instruments; Described slow releasing pharmaceutical coating is comprised of drug material, drug carrier material, antioxidant and binding agent;
Described drug material is selected the mixture of any one or at least two kinds in following material: heparin sodium, batroxobin, Ahylysantinfarctase, aspirin, hirudin, colchicine, rapamycin, Everolimus, Biolimus, Zotarolimus, Tracrolimus, atorvastatin, pravastatin, ciclosporin, Anti-CD34, dexamethasone, bleomycin, plicamycin, ametycin, actinomycin D, paclitaxel, tripterine, methotrexate;
Described drug carrier material is selected the mixture of any one or at least two kinds in following material: poly phosphate, biological species apatite, Heparinized Polymers, heparin, polylactic acid, iodixanol, Iopromide, carbamide, polyvinyl alcohol, lac, chitin;
Described antioxidant is selected the mixture of any one or at least two kinds in following material: Butylated hydroxyanisole, dibenzylatiooluene, calcium ascorbate, phospholipid, ascorbic acid, sodium ascorbate, vitamin E, Herba Rosmarini Officinalis extract and AOB;
Described binding agent is selected the mixture of any one or at least two kinds in following material: polymethyl methacrylate and derivant thereof, polybutyl methacrylate and derivant thereof, polyisobutyl methacrylate and derivant thereof.
Related content in technique scheme is explained as follows:
1,, in such scheme, preferably scheme is that described intervention class medical apparatus and instruments is that blood vessel is got involved class medical apparatus and instruments and non-blood vessel interventional medical device; It is arteria coronaria sacculus dilating catheter and support or peripheral vascular balloon dilatation catheter and support that wherein said blood vessel is got involved class medical apparatus and instruments; It is urethral dilatation support, dilatation of ureter support, biliary tract expandable stent or esophagectasia support that described non-blood vessel is got involved class medical apparatus and instruments.Targeted drug of the present invention discharges intracavity intervention class medical apparatus and instruments and is particularly suitable for treating the body cavity class diseases such as coronary artery, peripheral blood vessel, esophagus, biliary tract, urethra.
For achieving the above object, the technical scheme that a kind of targeted drug that the present invention adopts discharges the preparation method of intervention class medical apparatus and instruments is: this preparation method is included in process medicine coating on intervention class medical apparatus and instruments and forms targeted drug release intervention class medical apparatus and instruments, and the medicine of described intervention class medical apparatus and instruments applies and is comprised of successively the following step:
(1), the preparation of slow releasing pharmaceutical coating
A, preparation slow releasing pharmaceutical coating material, described slow releasing pharmaceutical coating material is comprised of drug material, drug carrier material, antioxidant and binding agent;
1., described drug carrier material is selected any one or at least two kinds of mixture with arbitrary proportion in following material: poly phosphate, biological species apatite, Heparinized Polymers, heparin, polylactic acid, iodixanol, Iopromide, carbamide, polyvinyl alcohol, lac, chitin;
2., described drug material is selected the mixture of any one or at least two kinds in following material: heparin sodium, batroxobin, Ahylysantinfarctase, aspirin, hirudin, colchicine, rapamycin, Everolimus, Biolimus, Zotarolimus, Tracrolimus, atorvastatin, pravastatin, ciclosporin, Anti-CD34, dexamethasone, bleomycin, plicamycin, ametycin, actinomycin D, paclitaxel, tripterine, methotrexate;
3., described antioxidant is selected any one or at least two kinds of mixture with arbitrary proportion in following material: Butylated hydroxyanisole, dibenzylatiooluene, calcium ascorbate, phospholipid, ascorbic acid, sodium ascorbate, vitamin E, Herba Rosmarini Officinalis extract and AOB;
4., described binding agent is selected the mixture of any one or at least two kinds in following material: polymethyl methacrylate and derivant thereof, polybutyl methacrylate and derivant thereof, polyisobutyl methacrylate and derivant thereof;
B, preparation solvent, any one or at least two kind mixture with arbitrary proportion of described solvent in selecting: formic acid, acetic acid, glycerol, ethanol, isopropyl alcohol, acetone, butanone, Ketohexamethylene, ethyl acetate, butyl acetate, oxolane, dichloromethane and normal hexane;
C, slow releasing pharmaceutical coating material is added in solvent, after mixing, stir, wherein, described drug carrier material, antioxidant, drug material and binding agent are 0.001 ~ 0.35,0.00002 ~ 0.0020,0.0005 ~ 0.20 and 0.00002 ~ 0.20 with the mass ratio of solvent respectively;
(2), the coating of slow releasing pharmaceutical coating
The slow releasing pharmaceutical coating that is dissolved with drug material, drug carrier material, antioxidant and binding agent is coated on to the surface of getting involved class medical apparatus and instruments by following process:
Ultrasonic atomizatio spraying, imbibition coating, injection coating, gas help the method for spraying, electrostatic spraying, piezoelectricity spraying, electrostatic spinning or dip-coating to be coated to the surface of getting involved class medical apparatus and instruments, and getting involved class medical apparatus surface medicament contg is 0.1 ~ 10 μ g/mm2;
(3), dry
The intervention class medical apparatus and instruments that is coated with slow releasing pharmaceutical coating is moved into temperature to be less than or equal to 90 ℃, to be more than or equal in the vacuum drying oven of 15 ℃ and to be dried.
Related content in technique scheme is explained as follows:
1,, in such scheme, preferably scheme is that described intervention class medical apparatus and instruments is that blood vessel is got involved class medical apparatus and instruments and non-blood vessel interventional medical device; It is arteria coronaria sacculus dilating catheter and support or peripheral vascular balloon dilatation catheter and support that wherein said blood vessel is got involved class medical apparatus and instruments; It is urethral dilatation support, dilatation of ureter support, biliary tract expandable stent or esophagectasia support etc. that described non-blood vessel is got involved class medical apparatus and instruments.
Design principle of the present invention and beneficial effect are: the present invention has added antioxidant materials, can guarantee that on the one hand intracavity intervention class medical apparatus and instruments stores in link in circulation, medicine can not produce because of the unstability of environmental condition the phenomenon of degraded, decomposition, dissolving, thereby affects therapeutic effect; Secondly, the use of adhesive material has strengthened the adhesion between coating solution and apparatus, make sacculus after coating in follow-up folding processing, and in external augmentation test, can not produce obvious slight crack and come off, guarantee the drug dose scope of targeting lesion in body, thereby reached therapeutic effect.It is high that targeted drug of the present invention discharges the slow releasing pharmaceutical coating and the intracavity intervention class medical apparatus surface adhesion strength that get involved on class medical apparatus and instruments, in following process process, drug material does not have loss, and the medication effect that targeted drug discharges intervention class medical apparatus and instruments is good.
Accompanying drawing explanation
Accompanying drawing 1 is the folding front medication coat SEM picture of the sacculus dilating catheter of the embodiment of the present invention one.
Accompanying drawing 2 is the medication coat SEM picture after the sacculus dilating catheter of the embodiment of the present invention one folds.
The specific embodiment
Below in conjunction with drawings and Examples, the invention will be further described:
Embodiment mono-: a kind of targeted drug discharges gets involved class medical apparatus and instruments and preparation method thereof
Intervention class medical apparatus and instruments used is arteria coronaria sacculus dilating catheter.By the polymethyl methacrylate of the polylactic acid of the paclitaxel of 100mg, 30mg, 5mg, (volume ratio is acetone: formic acid: vitamin E=8: 1:1) to be dissolved in the solution of 2ml acetone and formic acid and vitamin E, ultrasonic 10min, obtains finely dispersed medication coat storing solution.The balloon surface that is 3.0 * 20mm in dimensions by above-mentioned solution spraying, makes drug loading reach 3 μ g/mm
2left and right, dry, folding, obtain medicinal balloon, accompanying drawing 1 is its folding prodrug coating surface SEM picture, and from figure, we can find out that balloon surface is smooth, flawless, without fragment, produce, accompanying drawing 2 is medication coat surface SEM picture after folding, from figure, we can find out not disappearance of coating, and fragment etc., have still kept intact coating structure.
Embodiment bis-: a kind of targeted drug discharges gets involved class medical apparatus and instruments and preparation method thereof
Intervention class medical apparatus and instruments used is peripheral vascular balloon dilatation catheter.By the polybutyl methacrylate of the chitin of the paclitaxel of 200mg, 50mg, 18mg, (volume ratio is ethanol: acetic acid: vitamin E=7: 2:1) to be dissolved in the solution of 10ml ethanol, acetic acid and vitamin E, ultrasonic 10min, forms finely dispersed medication coat storing solution.The balloon surface that is 4.0x100mm in dimensions by above-mentioned solution dip-coating, makes drug loading reach 2 μ g/mm
2left and right, dries, folding, obtains medicinal balloon.
Embodiment tri-: a kind of targeted drug discharges gets involved class medical apparatus and instruments and preparation method thereof
Intervention class medical apparatus and instruments used is urethral dilatation support.By the polyisobutyl methacrylate of the iodixanol of the plicamycin of 400mg, 700mg, 400mg, (volume ratio is glycerol: acetone: Butylated hydroxyanisole=3: 6:1) to be dissolved in the solution of 2ml glycerol, acetone and Butylated hydroxyanisole, ultrasonic 10min, forms finely dispersed medication coat storing solution.Above-mentioned solution imbibition is coated to biliary tract expandable stent surface, make drug loading reach 9 μ g/mm
2left and right, dries, and obtains medicament slow release urethral dilatation support.
Embodiment tetra-: a kind of targeted drug discharges gets involved class medical apparatus and instruments and preparation method thereof
Intervention class medical apparatus and instruments used is biliary tract expandable stent.By the polybutyl methacrylate of the carbamide of the tripterine of 0.1mg, 2mg, 0.04mg, be dissolved in the solution (oxolane: ethanol: ascorbic acid=45: 54:1) of 2ml oxolane, ethanol and ascorbic acid, ultrasonic 10min, forms finely dispersed medication coat storing solution.In biliary tract expandable stent surface, make drug loading reach 1 μ g/mm above-mentioned solution electrostatic spraying
2left and right, dries, folding, obtains medicament slow release biliary tract expandable stent.
In above embodiment, drug material used can also be selected heparin sodium, the acceptable extract of reptilase pharmacy (as batroxobin), Ahylysantinfarctase, aspirin, hirudin, colchicine, rapamycin, Everolimus, Biolimus, Zotarolimus, Tracrolimus, atorvastatin, pravastatin, ciclosporin, Anti-CD34, dexamethasone, bleomycin, ametycin, actinomycin D, methotrexate; Drug carrier material used can also be selected poly phosphate, biological species apatite, heparin, polylactic acid, Iopromide, carbamide, polyvinyl alcohol, lac, chitin; Antioxidant used can also be selected dibenzylatiooluene, calcium ascorbate, phospholipid, sodium ascorbate, Herba Rosmarini Officinalis extract or AOB; Described binding agent can also be selected the derivant of the derivant of polymethyl methacrylate, the derivant of polybutyl methacrylate or polyisobutyl methacrylate; The all right formic acid of solvent used, isopropyl alcohol, butanone, Ketohexamethylene, ethyl acetate, butyl acetate, dichloromethane or normal hexane.Intervention class medical apparatus and instruments used can also be got involved class medical apparatus and instruments for the conventional intracavity well known to those skilled in the art such as coronary dilation support, periphery expandable stent, urethral dilatation support, esophagectasia support, dilatation of ureter support or biliary tract expandable stent.
Above-described embodiment is only explanation technical conceive of the present invention and feature, and its object is to allow person skilled in the art can understand content of the present invention and implement according to this, can not limit the scope of the invention with this.All equivalences that spirit is done according to the present invention change or modify, within all should being encompassed in protection scope of the present invention.
Claims (4)
1. targeted drug discharge to be got involved a class medical apparatus and instruments, it is characterized in that: described targeted drug discharges gets involved class medical apparatus and instruments by getting involved class medical apparatus and instruments and slow releasing pharmaceutical coating forms, and slow releasing pharmaceutical coating is on the surface of described intervention class medical apparatus and instruments; Described slow releasing pharmaceutical coating is comprised of drug material, drug carrier material, antioxidant and binding agent;
Described drug material is selected the mixture of any one or at least two kinds in following material: heparin sodium, batroxobin, Ahylysantinfarctase, aspirin, hirudin, colchicine, rapamycin, Everolimus, Biolimus, Zotarolimus, Tracrolimus, atorvastatin, pravastatin, ciclosporin, Anti-CD34, dexamethasone, bleomycin, plicamycin, ametycin, actinomycin D, paclitaxel, tripterine, methotrexate;
Described drug carrier material is selected the mixture of any one or at least two kinds in following material: poly phosphate, biological species apatite, Heparinized Polymers, heparin, polylactic acid, iodixanol, Iopromide, carbamide, polyvinyl alcohol, lac, chitin;
Described antioxidant is selected the mixture of any one or at least two kinds in following material: Butylated hydroxyanisole, dibenzylatiooluene, calcium ascorbate, phospholipid, ascorbic acid, sodium ascorbate, vitamin E, Herba Rosmarini Officinalis extract and AOB;
Described binding agent is selected the mixture of any one or at least two kinds in following material: polymethyl methacrylate and derivant thereof, polybutyl methacrylate and derivant thereof, polyisobutyl methacrylate and derivant thereof.
2. targeted drug according to claim 1 discharges and gets involved class medical apparatus and instruments, it is characterized in that: described intervention class medical apparatus and instruments is that blood vessel is got involved class medical apparatus and instruments and non-blood vessel interventional medical device; It is arteria coronaria sacculus dilating catheter and support or peripheral vascular balloon dilatation catheter and support that wherein said blood vessel is got involved class medical apparatus and instruments; It is urethral dilatation support, dilatation of ureter support, biliary tract expandable stent or esophagectasia support that described non-blood vessel is got involved class medical apparatus and instruments.
3. a kind of targeted drug according to claim 1 discharges the preparation method that gets involved class medical apparatus and instruments, be included on intervention class medical apparatus and instruments and discharge intervention class medical apparatus and instruments through medicine coating formation targeted drug, it is characterized in that: the medicine coating of described intervention class medical apparatus and instruments consists of successively the following step:
(1), the preparation of slow releasing pharmaceutical coating
A, preparation slow releasing pharmaceutical coating material, described slow releasing pharmaceutical coating material is comprised of drug material, drug carrier material, antioxidant and binding agent;
1., described drug carrier material is selected any one or at least two kinds of mixture with arbitrary proportion in following material: poly phosphate, biological species apatite, Heparinized Polymers, heparin, polylactic acid, iodixanol, Iopromide, carbamide, polyvinyl alcohol, lac, chitin;
2., described drug material is selected the mixture of any one or at least two kinds in following material: heparin sodium, batroxobin, Ahylysantinfarctase, aspirin, hirudin, colchicine, rapamycin, Everolimus, Biolimus, Zotarolimus, Tracrolimus, atorvastatin, pravastatin, ciclosporin, Anti-CD34, dexamethasone, bleomycin, plicamycin, ametycin, actinomycin D, paclitaxel, tripterine, methotrexate;
3., described antioxidant is selected any one or at least two kinds of mixture with arbitrary proportion in following material: Butylated hydroxyanisole, dibenzylatiooluene, calcium ascorbate, phospholipid, ascorbic acid, sodium ascorbate, vitamin E, Herba Rosmarini Officinalis extract and AOB;
4., described binding agent is selected the mixture of any one or at least two kinds in following material: polymethyl methacrylate and derivant thereof, polybutyl methacrylate and derivant thereof, polyisobutyl methacrylate and derivant thereof;
B, preparation solvent, any one or at least two kind mixture with arbitrary proportion of described solvent in selecting: formic acid, acetic acid, glycerol, ethanol, isopropyl alcohol, acetone, butanone, Ketohexamethylene, ethyl acetate, butyl acetate, oxolane, dichloromethane and normal hexane;
C, slow releasing pharmaceutical coating material is added in solvent, after mixing, stir, wherein, described drug carrier material, antioxidant, drug material and binding agent are 0.001 ~ 0.35,0.00002 ~ 0.0020,0.0005 ~ 0.20 and 0.00002 ~ 0.20 with the mass ratio of solvent respectively;
(2), the coating of slow releasing pharmaceutical coating
The slow releasing pharmaceutical coating that is dissolved with drug material, drug carrier material, antioxidant and binding agent is coated on to the surface of getting involved class medical apparatus and instruments by following process:
Ultrasonic atomizatio spraying, imbibition coating, injection coating, gas help the method for spraying, electrostatic spraying, piezoelectricity spraying, electrostatic spinning or dip-coating to be coated to the surface of getting involved class medical apparatus and instruments, and getting involved class medical apparatus surface medicament contg is 0.1 ~ 10 μ g/mm2;
(3), dry
The intervention class medical apparatus and instruments that is coated with slow releasing pharmaceutical coating is moved into temperature to be less than or equal to 90 ℃, to be more than or equal in the vacuum drying oven of 15 ℃ and to be dried.
4. a kind of targeted drug according to claim 3 discharges the preparation method that intracavity is got involved class medical apparatus and instruments, it is characterized in that: described intervention class medical apparatus and instruments is that blood vessel is got involved class medical apparatus and instruments and non-blood vessel interventional medical device; It is arteria coronaria sacculus dilating catheter and support or peripheral vascular balloon dilatation catheter and support that wherein said blood vessel is got involved class medical apparatus and instruments; It is urethral dilatation support, dilatation of ureter support, biliary tract expandable stent or esophagectasia support that described non-blood vessel is got involved class medical apparatus and instruments.
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Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105031741A (en) * | 2015-03-03 | 2015-11-11 | 江苏海泽医疗科技发展有限公司 | Medical catheter with anti-infective drug coating and drug slowly-releasing function and preparing method thereof |
| CN106512188A (en) * | 2016-12-13 | 2017-03-22 | 天津飞捷科技有限公司 | Mechanical and electrical integrated targeted drug release intervention medical instrument and preparation method thereof |
| CN109288832A (en) * | 2018-10-31 | 2019-02-01 | 浦易（上海）生物技术有限公司 | A kind of medication coat composition and its preparation method and application for ureter bracket |
| CN110384854A (en) * | 2019-08-02 | 2019-10-29 | 上海心玮医疗科技有限公司 | A kind of medicinal balloon and preparation method thereof that drug metabolism is controllable |
| CN110675717A (en) * | 2019-10-10 | 2020-01-10 | 吉林大学 | Bionic equipment for simulating vascular stenosis and thrombus |
| CN110665072A (en) * | 2019-11-23 | 2020-01-10 | 吉林省蔚来生物科技有限公司 | Targeted drug release interventional medical instrument and preparation method thereof |
| CN112023125A (en) * | 2019-06-03 | 2020-12-04 | 上海微创医疗器械（集团）有限公司 | Crystalline coating and preparation method thereof, drug-loaded implant medical device and preparation method thereof |
| CN112739392A (en) * | 2018-08-01 | 2021-04-30 | 波士顿科学国际有限公司 | Drug release coating composition |
| WO2022048270A1 (en) * | 2020-09-07 | 2022-03-10 | 上海鸿脉医疗科技有限公司 | Drug balloon and preparation method therefor |
| CN115300675A (en) * | 2022-03-21 | 2022-11-08 | 上海以心医疗器械有限公司 | Medical device with drug coating and preparation method and application thereof, drug coating and application thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1250382A (en) * | 1997-01-27 | 2000-04-12 | 斯蒂斯生物聚合物公司 | Bonding layers for medical device surface coatings |
| CN1261288A (en) * | 1997-06-23 | 2000-07-26 | 斯蒂斯生物聚合物公司 | Aderent, flexible hydrogel and medicated coatings |
| CN101147814A (en) * | 2007-11-16 | 2008-03-26 | 蔡绪旺 | Blood vessel medicine support |
| CN101185779A (en) * | 2007-12-19 | 2008-05-28 | 上海赢生医疗科技有限公司 | Method for preparing medicine sustained-releasing bracket |
-
2014
- 2014-05-19 CN CN201410209648.XA patent/CN103948975B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1250382A (en) * | 1997-01-27 | 2000-04-12 | 斯蒂斯生物聚合物公司 | Bonding layers for medical device surface coatings |
| CN1261288A (en) * | 1997-06-23 | 2000-07-26 | 斯蒂斯生物聚合物公司 | Aderent, flexible hydrogel and medicated coatings |
| CN101147814A (en) * | 2007-11-16 | 2008-03-26 | 蔡绪旺 | Blood vessel medicine support |
| CN101185779A (en) * | 2007-12-19 | 2008-05-28 | 上海赢生医疗科技有限公司 | Method for preparing medicine sustained-releasing bracket |
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105031741A (en) * | 2015-03-03 | 2015-11-11 | 江苏海泽医疗科技发展有限公司 | Medical catheter with anti-infective drug coating and drug slowly-releasing function and preparing method thereof |
| CN106512188A (en) * | 2016-12-13 | 2017-03-22 | 天津飞捷科技有限公司 | Mechanical and electrical integrated targeted drug release intervention medical instrument and preparation method thereof |
| CN112739392A (en) * | 2018-08-01 | 2021-04-30 | 波士顿科学国际有限公司 | Drug release coating composition |
| CN109288832A (en) * | 2018-10-31 | 2019-02-01 | 浦易（上海）生物技术有限公司 | A kind of medication coat composition and its preparation method and application for ureter bracket |
| CN112023125A (en) * | 2019-06-03 | 2020-12-04 | 上海微创医疗器械（集团）有限公司 | Crystalline coating and preparation method thereof, drug-loaded implant medical device and preparation method thereof |
| CN110384854A (en) * | 2019-08-02 | 2019-10-29 | 上海心玮医疗科技有限公司 | A kind of medicinal balloon and preparation method thereof that drug metabolism is controllable |
| WO2021022799A1 (en) * | 2019-08-02 | 2021-02-11 | 上海心玮医疗科技股份有限公司 | Drugcoated balloon controllable in drug metabolism and preparation method therefor |
| CN110675717A (en) * | 2019-10-10 | 2020-01-10 | 吉林大学 | Bionic equipment for simulating vascular stenosis and thrombus |
| CN110665072A (en) * | 2019-11-23 | 2020-01-10 | 吉林省蔚来生物科技有限公司 | Targeted drug release interventional medical instrument and preparation method thereof |
| WO2022048270A1 (en) * | 2020-09-07 | 2022-03-10 | 上海鸿脉医疗科技有限公司 | Drug balloon and preparation method therefor |
| CN115300675A (en) * | 2022-03-21 | 2022-11-08 | 上海以心医疗器械有限公司 | Medical device with drug coating and preparation method and application thereof, drug coating and application thereof |
| WO2023179082A1 (en) * | 2022-03-21 | 2023-09-28 | 上海以心医疗器械有限公司 | Drug coating medical instrument, preparation method therefor and use thereof, and drug coating and use thereof |
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