CN104173808A

CN104173808A - Traditional Chinese medicine for treatment of liver-fire flaming up type hypertension and preparation method thereof

Info

Publication number: CN104173808A
Application number: CN201410440843.3A
Authority: CN
Inventors: 于美芹
Original assignee: 于美芹
Current assignee: Sichuan Shuang Xin Pharmaceutical Co., Ltd.
Priority date: 2014-09-02
Filing date: 2014-09-02
Publication date: 2014-12-03
Anticipated expiration: 2034-09-02
Also published as: CN104173808B

Abstract

The invention provides a traditional Chinese medicine for treatment of liver-fire flaming up type hypertension and a preparation method thereof. The traditional Chinese medicine comprises the following raw materials: prunella vulgaris, cassia seed, pale butterflybush flower, pipewort, seed of feather cockscomb, gentianella, wild chrysanthemum flower, radix bistortae, radix puerariae, radix gentianae macrophyllae, radix stephaniae tetrandrae, ramulus mori, herba siegesbeckiae, harlequin glorybower leaf and twig, retinervus luffae fructus, rhizoma dioscoreae nipponicae, herba taxilli, fossilia ossis mastoid, nacre, concha mauritiae, apocynum, uncaria, batryticated silkworm, indigo naturalis, infected foxtail millet spike bran, emarginate amaranth herb and stringy stonecrop. The traditional Chinese medicine for treatment of liver-fire flaming up type hypertension has the beneficial effects of clearing heat from the liver and eliminating dampness and heat, is mainly used for treating liver-fire flaming up type hypertension by adjusting the entire blood circulation as well as blood viscosity based on the theory of the traditional Chinese medicine to make diagnosis and treatment on the basis of overall view, is designed for targeted treatment for similar diseases by directing to the focus, has wide indications, obvious efficacy and less adverse reaction, is convenient in administration and accepted easily by patients, and can be popularized clinically.

Description

One is treated hypertensive Chinese medicine of flaming-up of the liverfire type and preparation method thereof

Technical field

The present invention relates to pharmaceutical technology, relate in particular to one and treat hypertensive Chinese medicine of flaming-up of the liverfire type and preparation method thereof

Background technology

Hypertension is the disease that continues hyperpiesia, can cause the diseases such as apoplexy, heart disease, hemangioma, renal failure, hypertension is a kind of taking arterial pressure rising as feature, can be functional with heart, blood vessel, brain and kidney and other organs or the systemic disease of organic change, it have essential hypertension and secondary hypertension point.The reason of hypertension incidence is a lot, can be divided into two aspects of h and E.Do not using in antihypertensive situation, systolic pressure >=139mmHg and/or diastolic pressure >=89mmHg, be divided into 1,2 by blood pressure level by hypertension, 3 grades.Systolic pressure >=140mmHg and diastolic pressure <90mmHg are single-row is isolated systolic hypertension.Patient previously has history of hypertension, is using at present antihypertensive, although blood pressure, lower than 140/90mmHg, also should be diagnosed as hypertension.

The factor relevant with morbidity

1. at the age: sickness rate has the trend increasing with age growth, more than 40 years old person sickness rate is high.

2. Sal: take in the many persons of Sal, Hypertension incidence is high, has the Sal of thinking <2g/ day, and hypertension occurs hardly; 3-4g/ day, Hypertension incidence 3%, 4-15g/ day, sickness rate 33.15%, >20g/ day sickness rate 30%.

3. body weight: overweight people's sickness rate is high.

4. heredity: approximately half hyperpietic has family history.

5. environment and occupation: have the working environment of noise, hypertension all easily occurs overwrought mental work, and the high pressure sickness rate in city is higher than rural area.

Etiology and pathogenesis

1. feelings will internal injury innate excess of YANG in the body, in addition angry excessive, excessive rising of liver-YANG, sun rises pneumatic, sends out as dizzy; Or because of long-term melancholy angry, stagnated QI transforming into fire, secretly consumes liver-yin, excessive rising of liver-YANG, sun rises pneumatic, and pathogen upward attacking orifices in head is sent out as dizzy.

2, eating and drinking without temperance, impairing the spleen and stomach, weakness of the spleen and stomach, no resource of generating and transforming QI and blood, YANG-orifices failing to be nourished and do dizzy; Or the delicious food of being addicted to drink, hungry full overstrain, hinders in taste, be good for fortune mistake department, so that indigestion is precise and tiny, accumulatively wet raise phlegm, and stagnation of phlegm-damp in middle-JIAO, turbid YIN failing to descend, causes dizzy.

3. after wound, operation injury of head or operation, qi depression to blood stasis, numbness hinders clear key, sends out as dizzy.

4. body void, prolonged illness, lose blood, the kidney being the origin of congenital constitution for overstrain, the raw marrow of store essential substances, if congenital defect, kidney essense is not filled, or old deficiency of the kidney, or prolonged illness is impairment of the kidney, or excess of sexual intercourse, cause deficiency of kidney-essence, can not give birth to marrow, and the brain being the reservoir of the marrow, deficiency of marrow-reservoir, all empty up and down, and occur dizzy.Or chronic deficiency of kidney-YIN, the liver failing to be nourished, so that deficiecny of liver-YIN, the moon sun not processed, excessive rising of liver-YANG, sends out as dizzy.Serious disease prolonged illness or lose blood after, empty and multiple, or overstrain, QI and blood declines few, QI and blood deficiency, the deficiency of vital energy clear sun is not opened up, blood deficiency brain is become homeless fosterly, all can occur dizzy.

Hypertension is by stages:

The first phase: blood pressure reaches Definite Hypertension level, be not clinically in the mood for, brain, renal damage sign.

The second phase: blood pressure reaches Definite Hypertension level, and have a following 1. health check-up of person, x-ray, electrocardiogram or ultrasonic cardiography diagram left ventricle to expand.2. examination of ocular fundus, the general or local stenosis of optical fundus tremulous pulse.3. albuminuria or creatinine concentration of plasma slightly increase.

The third phase: blood pressure reaches Definite Hypertension level, and have a following person; 1. cerebral hemorrhage or hypertensive encephalopathy.2. heart failure.3. renal failure.4. retinal hemorrhage or ooze out, companion or without papilloedema.5. angina pectoris, myocardial infarction, cerebral thrombosis.

Hypertension with traditional Chinese Medical classification:

1, excessive rising of liver-YANG symptom: vertigo and tinnitus, headache and swollen, meets labor, angry increasing the weight of, and limb fiber crops are trembled, insomnia and dreamful sleep, being irritable and getting angry easily, red tongue with yellow fur, stringy pulse.

2, flaming up of liver-fire symptom: dizzy and pain, its gesture is more acute, red eyes and bitter taste in the mouth, distending pain in the chest and hypochondrium, irritated irritability, few dreaminess of sleeping, yellow urine, constipation with dry stool, red tongue with yellow fur, wiry and frequent pulse.

3, the turbid upper illiteracy symptom of expectorant: dizzy, heaviness of the head as being covered, depending on thing rotation, uncomfortable in chest doing evil, vomiting sputum, lack of appetite drowsirness, tongue is greasy in vain, stringy and rolling pulse.

4, obstruction of the orifices by blood stasis symptom: dizziness and headache, double see forgetful, insomnia, cardiopalmus, lassitude, Hiccough and deaf, face purple lip is dark, tongue petechia or ecchymosis, stringy and hesitant pulse or carefully puckery.

5, deficiency of qi and blood symptom: have a dizzy spell, moving aggravation, meet Lao Zefa, complexion an ancient wine vessel made of horn is white, lustrelessness of the nails, spiritlessness and weakness, palpitation and sleeplessness, poor appetite lack of appetite, loose stool, pale tongue with thin fur is white, thready and weak pulse.

6, hepatic and renal YIN deficiency symptom: dizzy of a specified duration endlessly, visual deterioration, two dryness and uneasy feeling of the eye, sleep forgetful less, vexed xerostomia, tinnitus, spiritlessness and weakness, soreness of waist and knee, seminal emission, red tongue with thin fur, stringy and thready pulse.

The treatment of western medical treatment hypertension medicine:

(1) angiotensin converting enzyme inhibitor: apply at present captopril, enalapril.

(2) calcium antagonist: be one group of chemical constitution difference, the medicine that mechanism of action is also not quite similar.Owing to suppressing calcium ion by the interior stream of calcium channel on cell membrane, thereby be called calcium-channel antagonists.Common drug has verapamil, diltiazem and nifedipine, nitrendipine.

(3) vasodilation: directly lax vascular smooth muscle, blood vessel dilating, reduces blood pressure.Common drug has: 1. sodium nitroprusside.2. Minoxidil.3. Aiselazine.

(4) act on the depressor of sympathetic nervous system.

1. central sympathetic nerve depressant: (1) clonidine; (2) methyldopa.

2. sympathetic block agent.Dust head has arfonad, for the treatment of hypertensive encephalopathy.

3. blocker after sympathetic ganglion.The slightly middle norepinephrine storage in sympathetic nerve end is exhausted, and reach the object of blood pressure lowering.Common drug has: (1) guanethidine.(2) reserpine.

4. adrenergic receptor blocker.

(1) beta-blocker; Labetalol is the depressor that WHO recommends.Acebutolol.

(2) α receptor blocking agent: dust head has prazosin.Doxazosin.

(5) diuretic antihypertensive medicine.

1. thiazide: be most widely used oral diuretic antihypertensive medicine, hydrochlorothiazide;

2. chlortalidone;

3. furosemide;

4. triamterene.

But western medical treatment hypertension is longer the course for the treatment of, a large amount of depressor of prolonged application easily produces drug resistance, lessens the curative effect, and adverse effect is more, personalized medicine, and associating, Grading treatment, clinical efficacy is not satisfactory, affects patient's quality of life.

But Chinese medicine hypertension, has complete theoretical system, possess unique advantage and feature: utilize Traditional Chinese medical theory, by adjusting whole blood circulation, regulate blood viscosity etc., on the basis of Overall View, carry out determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, carry out magnetic target therapy for similar disease, the drug effect focus of going directly, indication is wider, evident in efficacy, untoward reaction is less, convenient drug administration, patient is easy to accept, and can carry out clinical marketing.

Summary of the invention

Technical problem to be solved by this invention is, provides one to have purging liver-fire, and effect of clearing away heat-damp and promoting diuresis cures mainly the new drug of hypertension syndrome of liver fire flaring up.The present invention has treatment hypertension, has complete theoretical system, possesses unique advantage and feature: utilize Traditional Chinese medical theory, by adjusting whole blood circulation, regulate blood viscosity etc., on the basis of Overall View, carry out determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, carry out magnetic target therapy for similar disease, the drug effect focus of going directly, indication is wider, evident in efficacy, untoward reaction is less, convenient drug administration, patient is easy to accept, and can carry out clinical marketing.

In order to solve the problems of the technologies described above, the invention provides one and treat the hypertensive Chinese medicine of flaming-up of the liverfire type, comprise following raw medicinal material: Spica Prunellae, Semen Cassiae, Flos Buddlejae, Flos Eriocauli, Semen Celosiae, Radix Gentianae, Flos Chrysanthemi Indici, Rhizoma Bistortae, Radix Puerariae, Radix Gentianae Macrophyllae, Radix Stephaniae Tetrandrae, Ramulus Mori, Herba Siegesbeckiae, Folium et Ramulus Clerodendri Trichotomi, Retinervus Luffae Fructus, Rhizoma Dioscoreae Nipponicae, Herba Taxilli, Os Draconis, Concha Margaritifera, Concha Erosariae seu Cypraeae, Herba Apocyni veneti, Ramulus Uncariae Cum Uncis, Bombyx Batryticatus, Indigo Naturalis, Semen Setariae italicae, le Amaranthus mangostanus L. and Herba Sedi.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material is: 15～30 parts of Spica Prunellaes, 13～27 parts of Semen Cassiaes, 11～25 parts of Flos Buddlejaes, 22～36 parts of Flos Eriocaulis, 23～38 parts of Semen Celosiae, 12～24 parts of Radix Gentianae, 16～29 parts of Flos Chrysanthemi Indicis, 30～40 parts of Rhizoma Bistortaes, 16～27 parts of Radix Puerariaes, 18～33 parts of Radix Gentianae Macrophyllae, 15～31 parts of Radixs Stephaniae Tetrandrae, 20～35 parts of Ramulus Moris, 18～33 parts of Herba Siegesbeckiaes, 10～25 parts of Folium et Ramulus Clerodendri Trichotomis, 13～29 parts of Retinervus Luffae Fructuss, 12～25 parts of Rhizoma Dioscoreae Nipponicae, 13～29 parts of Herba Taxillis, 18～30 parts of Os Draconis, 12～28 parts of Concha Margaritiferas, 11～26 parts of Concha Erosariae seu Cypraeae, 20～35 parts of Herba Apocyni venetis, 10～22 parts of Ramulus Uncariae Cum Uncis, 15～28 parts of Bombyx Batryticatus, 7～18 parts of Indigo Naturaliss, 15～30 parts of Semen Setariae italicaes, 14～27 parts of 23～36 parts of le Amaranthus mangostanus L.s and Herba Sedis.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material is: 18～28 parts of Spica Prunellaes, 15～23 parts of Semen Cassiaes, 13～22 parts of Flos Buddlejaes, 25～31 parts of Flos Eriocaulis, 23～30 parts of Semen Celosiae, 14～22 parts of Radix Gentianae, 17～26 parts of Flos Chrysanthemi Indicis, 30～38 parts of Rhizoma Bistortaes, 17～25 parts of Radix Puerariaes, 19～31 parts of Radix Gentianae Macrophyllae, 16～28 parts of Radixs Stephaniae Tetrandrae, 23～32 parts of Ramulus Moris, 19～32 parts of Herba Siegesbeckiaes, 11～24 parts of Folium et Ramulus Clerodendri Trichotomis, 14～25 parts of Retinervus Luffae Fructuss, 14～24 parts of Rhizoma Dioscoreae Nipponicae, 16～28 parts of Herba Taxillis, 19～26 parts of Os Draconis, 14～23 parts of Concha Margaritiferas, 12～23 parts of Concha Erosariae seu Cypraeae, 24～35 parts of Herba Apocyni venetis, 11～21 parts of Ramulus Uncariae Cum Uncis, 17～25 parts of Bombyx Batryticatus, 7～14 parts of Indigo Naturaliss, 15～25 parts of Semen Setariae italicaes, 15～25 parts of 23～33 parts of le Amaranthus mangostanus L.s and Herba Sedis.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material is: 18 parts of Spica Prunellaes, 17 parts of Semen Cassiaes, 22 parts of Flos Buddlejaes, 28 parts of Flos Eriocaulis, 23 parts of Semen Celosiae, 19 parts of Radix Gentianae, 23 parts of Flos Chrysanthemi Indicis, 35 parts of Rhizoma Bistortaes, 25 parts of Radix Puerariaes, 31 parts of Radix Gentianae Macrophyllae, 28 parts of Radixs Stephaniae Tetrandrae, 30 parts of Ramulus Moris, 19 parts of Herba Siegesbeckiaes, 13 parts of Folium et Ramulus Clerodendri Trichotomis, 25 parts of Retinervus Luffae Fructuss, 19 parts of Rhizoma Dioscoreae Nipponicae, 16 parts of Herba Taxillis, 26 parts of Os Draconis, 17 parts of Concha Margaritiferas, 21 parts of Concha Erosariae seu Cypraeae, 35 parts of Herba Apocyni venetis, 19 parts of Ramulus Uncariae Cum Uncis, 17 parts of Bombyx Batryticatus, 14 parts of Indigo Naturaliss, 22 parts of Semen Setariae italicaes, 15 parts of 26 parts of le Amaranthus mangostanus L.s and Herba Sedis.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material is: 28 parts of Spica Prunellaes, 23 parts of Semen Cassiaes, 13 parts of Flos Buddlejaes, 31 parts of Flos Eriocaulis, 30 parts of Semen Celosiae, 22 parts of Radix Gentianae, 17 parts of Flos Chrysanthemi Indicis, 38 parts of Rhizoma Bistortaes, 17 parts of Radix Puerariaes, 26 parts of Radix Gentianae Macrophyllae, 16 parts of Radixs Stephaniae Tetrandrae, 32 parts of Ramulus Moris, 32 parts of Herba Siegesbeckiaes, 24 parts of Folium et Ramulus Clerodendri Trichotomis, 20 parts of Retinervus Luffae Fructuss, 14 parts of Rhizoma Dioscoreae Nipponicae, 28 parts of Herba Taxillis, 19 parts of Os Draconis, 23 parts of Concha Margaritiferas, 12 parts of Concha Erosariae seu Cypraeae, 24 parts of Herba Apocyni venetis, 21 parts of Ramulus Uncariae Cum Uncis, 25 parts of Bombyx Batryticatus, 8 parts of Indigo Naturaliss, 15 parts of Semen Setariae italicaes, 25 parts of 23 parts of le Amaranthus mangostanus L.s and Herba Sedis.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material is: 20 parts of Spica Prunellaes, 15 parts of Semen Cassiaes, 19 parts of Flos Buddlejaes, 25 parts of Flos Eriocaulis, 29 parts of Semen Celosiae, 14 parts of Radix Gentianae, 26 parts of Flos Chrysanthemi Indicis, 30 parts of Rhizoma Bistortaes, 21 parts of Radix Puerariaes, 19 parts of Radix Gentianae Macrophyllae, 22 parts of Radixs Stephaniae Tetrandrae, 23 parts of Ramulus Moris, 23 parts of Herba Siegesbeckiaes, 11 parts of Folium et Ramulus Clerodendri Trichotomis, 14 parts of Retinervus Luffae Fructuss, 24 parts of Rhizoma Dioscoreae Nipponicae, 27 parts of Herba Taxillis, 25 parts of Os Draconis, 14 parts of Concha Margaritiferas, 23 parts of Concha Erosariae seu Cypraeae, 32 parts of Herba Apocyni venetis, 11 parts of Ramulus Uncariae Cum Uncis, 19 parts of Bombyx Batryticatus, 7 parts of Indigo Naturaliss, 25 parts of Semen Setariae italicaes, 21 parts of 33 parts of le Amaranthus mangostanus L.s and Herba Sedis.

In the time that the dosage form of described Chinese medicine is honey refining pill, its preparation method comprises the following steps:

Step 1: first Spica Prunellae, Semen Cassiae, Flos Buddlejae, Flos Eriocauli, Semen Celosiae, Radix Gentianae, Flos Chrysanthemi Indici, Rhizoma Bistortae and Radix Puerariae are mixed in described ratio, distillation crystallization obtains powder;

Step 2: get again surplus stock medical material and mix in described ratio, add 83-94% soak with ethanol 1-2 hour, the heating extraction 2 times doubly measured with respect to mixture 2-6, each 1-1.5 hour, merge extractive liquid,, 124-150 order filter, be the ultrafiltration post ultrafiltration of 4400-98000 again through the molecular weight that dams, the extractum that when ultrafiltrate is evaporated to 87 DEG C, relative density is 1.04, becomes component 1;

Step 3: step 2 Chinese medicine slag is added to 4-6 times of water gaging and soak 1-2.5 hour, extract 1 time, extraction time is 1.5-2 hour, and thickening filtration is extractum shape, is component 2;

Step 4: said components 1 and 2 two kinds of extractum of component are condensed into pasty state, add the powder that step 1 obtains, add Mel and be twisted into pill.

In the time that the dosage form of described Chinese medicine is granule, its preparation method comprises the following steps:

Step 1: described raw medicinal material is mixed in described ratio, the ethanol that to add with respect to the determining alcohol of 4～8 times, mixture be 85%～95%, be heated to boiling reflux 3～5 hours, filter, adopt the speed slowly percolation of percolation with 1～2ml per minute, collect percolate, the mastic that while being evaporated to 50～60 DEG C subsequently under vacuum 0.06～0.09Mpa, relative density is 1.04～1.10, spraying is dry, 160～175 DEG C of the inlet temperature of spray dryer, 80～85 DEG C of leaving air temps, be ground into subsequently powder, make dried cream powder;

Step 2: in the dried cream powder obtaining, add with respect to the cane sugar powder of 0.2～0.4 times of dried cream powder quality and the dextrin of 0.1～0.2 times, granulation, in 40～50 DEG C dry, obtain granule.

The dosage form of described Chinese medicine is for containing tablet, and its preparation method comprises the following steps:

The first step, Spica Prunellae, Semen Cassiae, Flos Buddlejae, Flos Eriocauli, Semen Celosiae, Radix Gentianae and Flos Chrysanthemi Indici are mixed in described ratio, use the soak with ethanol with respect to the determining alcohol 90%～95% of 4～6 times of the mixture quality obtaining, reflux was extracted after 2～4 hours, filtered; Filtering residue is used to the soak with ethanol with respect to the determining alcohol 85%～95% of 2～4 times of the mixture quality obtaining again, and reflux was extracted after 1～2 hour, filtered; Merge filtrate twice, decompression recycling ethanol to be concentrated into liquor strength be 0.8～1.2g crude drug/mL, utilize twice of the macroporous adsorptive resins eluting that volume is 5L, first use deionized water or the distilled water eluting of 5 times of resin column volumes, be 90%～95% ethanol elution with the determining alcohol of 3 times of resin column volumes again, collect ethanol elution, concentrating under reduced pressure is removed ethanol, is dried and is ground into powder;

Second step, Rhizoma Bistortae, Radix Puerariae, Radix Gentianae Macrophyllae, Radix Stephaniae Tetrandrae, Ramulus Mori, Herba Siegesbeckiae, Folium et Ramulus Clerodendri Trichotomi and Retinervus Luffae Fructus are mixed in described ratio, add with respect to obtain mixture quality the determining alcohol 85%～95% of 3～5 times alcohol heating reflux extract 2 times, extracted twice liquid merges, with the centrifugal remove impurity of tube centrifuge, the mastic that when extracting solution after remove impurity is evaporated to 60 DEG C under the condition of 60 DEG C～70 DEG C, relative density is 1.20～1.23, is dried to powder by the mastic after concentrated with spray dryer;

The 3rd step, mixes surplus stock medical material in described ratio, add the water soaking of 2～5 times with respect to the mixture quality obtaining, and heating decocts 2～4 hours, filters; Filtering residue is used to the water soaking of 1～3 times with respect to the mixture quality obtaining again, and heating decocts 1～2 hour, filters; Merge filtrate twice, concentrating under reduced pressure is removed moisture, is dried and is ground into powder;

The 4th step, the powder that the first step, second step and the 3rd step are obtained mixes, further add with respect to the carboxymethyl starch sodium of 0.05～0.1 times of the mixture quality obtaining, the microcrystalline Cellulose of 0.05～0.1 times, mix, granulate, after being dried, add the magnesium stearate with respect to 0.01～0.05 times of the mixture quality obtaining, then with decompressor, granule is suppressed in flakes, obtained containing tablet.

Beneficial effect of the present invention: Chinese medicine of the present invention has purging liver-fire, effect of eliminating damp-heat, cures mainly flaming-up of the liverfire type hypertension.The present invention treats hypertension complete theoretical system, possesses unique advantage and feature: utilize Traditional Chinese medical theory, by adjusting whole blood circulation, regulate blood viscosity etc., on the basis of Overall View, carry out determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, carry out magnetic target therapy for similar disease, the drug effect focus of going directly, indication is wider, evident in efficacy, untoward reaction is less, convenient drug administration, patient is easy to accept, and can carry out clinical marketing.

Detailed description of the invention

Chinese medicine thinks, the primary disease cause of disease is many by feelings will, injury due to diet, and lose blood, due to wound, overstrain.Its sick position is at clear key, and by violating on brains inanition, YANG-orifices failing to be nourished and phlegm-fire, blood stasis due to clear key, relevant with the dirty functional disorder of liver,spleen,kidney three, its morbidity is in the majority with deficiency syndrome.Excess syndrome is more common in the onset of vertigo phase clinically, common with excessive rising of liver-YANG, flaming up of liver-fire, the turbid upper illiteracy of expectorant, obstruction of the orifices by blood stasis four types.

Therefore, the present invention treats flaming-up of the liverfire type hypertension with purging liver-fire, eliminating damp-heat is primary treatment principle, selects prescription: Spica Prunellae, Semen Cassiae, Flos Buddlejae, Flos Eriocauli, Semen Celosiae, Radix Gentianae, Flos Chrysanthemi Indici, Rhizoma Bistortae, Radix Puerariae, Radix Gentianae Macrophyllae, Radix Stephaniae Tetrandrae, Ramulus Mori, Herba Siegesbeckiae, Folium et Ramulus Clerodendri Trichotomi, Retinervus Luffae Fructus, Rhizoma Dioscoreae Nipponicae, Herba Taxilli, Os Draconis, Concha Margaritifera, Concha Erosariae seu Cypraeae, Herba Apocyni veneti, Ramulus Uncariae Cum Uncis, Bombyx Batryticatus, Indigo Naturalis, Semen Setariae italicae, le Amaranthus mangostanus L. and Herba Sedi.

Wherein, Spica Prunellae, Semen Cassiae, Flos Buddlejae, Flos Eriocauli, Semen Celosiae, Radix Gentianae, Flos Chrysanthemi Indici, Rhizoma Bistortae, Radix Puerariae and the removing toxic substances of Indigo Naturalis clearing away heat-fire; Radix Gentianae Macrophyllae, Radix Stephaniae Tetrandrae, Ramulus Mori, Herba Siegesbeckiae, Folium et Ramulus Clerodendri Trichotomi, Retinervus Luffae Fructus, Rhizoma Dioscoreae Nipponicae, Herba Taxilli, Semen Setariae italicae, le Amaranthus mangostanus L. and Herba Sedi clearing away heat and eliminating dampness dredging collateral; Os Draconis, Concha Margaritifera, Concha Erosariae seu Cypraeae suppressing the hyperactive liver and subsiding YANG, calm the nerves; Herba Apocyni veneti, Ramulus Uncariae Cum Uncis, Bombyx Batryticatus suppressing liver-YANG, clearing away heat and relieving the wind syndrome.Full side's compatibility is rigorous, by adjusting whole blood circulation, regulates blood viscosity etc., carries out magnetic target therapy for similar disease, the drug effect focus of going directly, and indication is wider, and untoward reaction is less, evident in efficacy.

Wherein, the pharmacology of above-mentioned raw materials medical material is as follows:

Spica Prunellae: bitter in the mouth, pungent, cold in nature, enter liver, gallbladder meridian, " herbal classic ": " main cold and heat, scrofula, scrofula, head sore, broken disease, loose wart stagnation of QI, swelling of the feet arthralgia chiefly caused by damp pathogen." " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " liver-wind of dispelling, the network of passing through, controls facial hemiparalysis.Row irritability, opens stagnation of liver-QI, only bones and muscles pain, ophthal malgia, and loose scrofula is stolen, whole body tuberculosis." have and relieve inflammation or internal heat, improving eyesight, eliminating stagnation, effect of detumescence, cures mainly conjunctival congestion and swelling pain, and order pearl nyctalgia, has a headache dizzy, scrofula, goiter, swells and ache; Thyromegaly, tuberculous lymphadenitis, cyclomastopathy, the cards such as hypertension, hyperglycemia, hyperlipidemia and high blood viscosity.

Semen Cassiae: bitter in the mouth, cold nature, enters large intestine, kidney, Liver Channel, has purging liver-fire, the effect of loosening bowel to relieve constipation, for the puckery pain of conjunctival congestion, the many tear of photophobia, the cards such as dizzy, poor vision, constipation of having a headache.

Flos Buddlejae: sweet in the mouth, cold nature.Return liver, gallbladder meridian.Main optic atrohic blindness skin nebula, red puckery many eye secretion and tears, blood vessel in the order that disappears, children's's bran bean and infantile malnutrition gas are attacked eye.Function heat clearing away nourishing the liver, improving acuity of vision and removing nebula.For conjunctival congestion and swelling pain, many tear photophobia, liver heat removing and eyesight improving, the raw nebula film of order, hepatasthenia dim eyesight, blurring of vision, relieving cough and asthma, looks improving and the skin nourishing.

Flos Eriocauli: pungent, sweet, flat.Return liver, lung meridian.Dispelling wind and heat pathogens, improving eyesight, nebula removing.For wind heat conjunctival congestion, the photophobia that swells and ache, the nebula of looking unfamiliar film, headache due to pathogenic wind-heat.

Semen Celosiae: hardship, is slightly cold.Enter the heart, liver two warps.Effect liver heat removing and eyesight improving, clearing away heat-fire, improving acuity of vision and removing nebula.Cure mainly conjunctival congestion and swelling pain, the nebula of looking unfamiliar film, blurring of vision, hypertension, epistaxis, skin wind heat pruritus, skin ulcer tinea.The hot conjunctival congestion of Semen Celosiae treating the liver, the nebula of looking unfamiliar film, blurring of vision.

Radix Gentianae: bitter in the mouth, cold in nature; Return liver, gallbladder meridian.Function heat clearing and damp drying, eliminating pathogen in the liver arresting convulsion.Cure mainly jaundice due to damp-heat, urine leaching pain, swelling of the vulva pudendal pruritus, damp-heat vaginal discharge, the feeling of fullness in the head headache of liver and gall excess-fire, conjunctival congestion and swelling pain, deaf ear is swollen, hypochondriac pain bitter taste, calentura convulsion with spasms.

Flos Chrysanthemi Indici: cold nature, bitter in the mouth, pungent.Function heat-clearing and toxic substances removing, detumescence.To staphylococcus aureus, diphtheria corynebacterium, streptococcus, bacillus pyocyaneus, puncture Shigella, influenza virus, all there is inhibitory action.To furuncle, carbuncle, erysipelas, eczema, dermatitis, anemopyretic cold, laryngopharynx swelling and pain, hypertension etc. have good curative effect.

Rhizoma Bistortae: hardship, cool; Return lung, liver, large intestine channel.Heat clearing away is relieving convulsion, the wet detumescence of reason.Control that calentura is frightened jerks, tetanus, bloody dysentery, carbuncle, scrofula, tetany, snake bite and insect sting.。

Radix Puerariae: cool in nature, sweet in the mouth, pungent, enters spleen, stomach warp.Can yang invigorating expelling pathogenic factors from muscles, rash antidiarrheal, relieving restlessness is temperature only.Cold, the warm headache stiffness of the nape that cures the wound, dysphoria with smothery sensation is quenched one's thirst, has loose bowels, dysentery, skin eruption is not saturating, hypertension, angina pectoris, deafness.

Radix Gentianae Macrophyllae: pungent, bitter, be slightly cold.Return stomach warp, Liver Channel, gallbladder meridian.Eradicates rheumatism, relaxing muscles and tendons network, clearind deficient heat.For rheumatic arthralgia, the contracture of muscle arteries and veins, joint is ached, afternoon fever, infantile malnutrition heating.Rheumatic arthralgia, the contracture of muscle arteries and veins, joint is ached, newly for a long time all can compatibility application without inquiring about chills and fever.

Radix Stephaniae Tetrandrae: nature and flavor hardship, cold.Enter bladder, spleen, kidney channel.Effect: inducing diuresis to remove edema, wind-expelling pain-stopping.Cure mainly: edema beriberi, dysuria, eczema sore, rheumatic arthralgia, vascular hypertension.

Ramulus Mori: hardship; Property is put down.Return Liver Channel.Wind-damp dispelling; The meridian dredging; Row aqueous vapor.Main air pain of dampness syndrome; Apoplexy and hemiplegia; Edema foot gas; Human body pruritus due to wind pathogen.

Herba Siegesbeckiae: pungent, bitter, cold.Return liver, kidney channel.Wind-damp dispelling, sharp joint, removing toxic substances.For rheumatic arthralgia, muscles and bones is unable, soreness of the waist and knees, quadriplegia, hemiplegia, rubella eczema.Control apoplectic aphasia in silence, facial hemiparalysis, time salivation.Tonify deficiency, settling five organs, piliation.Bright eyes, black moustache is sent out, strong biceps.Control apoplectic aphasia in silence, facial hemiparalysis, time salivation.Tonify deficiency, settling five organs, piliation.Bright eyes, black moustache is sent out, strong biceps.Function wind-damp dispelling, sharp joint, removing toxic substances.

Folium et Ramulus Clerodendri Trichotomi: pungent, bitter, sweet, cool.Enter Liver Channel, gallbladder meridian, spleen channel.Wind-damp dispelling.Cure mainly: dispelling the wind and dampness pathogens arthralgia pain, hemiplegia, hypertension, migraine; Malaria, dysentery, hemorrhoid, carbuncle skin ulcer scabies.。

Retinervus Luffae Fructus: cool in nature, sweet in the mouth.Enter lung, stomach, Liver Channel.Bitter in the mouth; Cool in nature.Return lung; Liver; Stomach warp.Dredge the meridian passage; Removing toxic substances and promoting subsidence of swelling.Main pain in chest and hypochondrium; Rheumatic arthralgia, passages through which vital energy circulates contracture, galactostasis, the cough of lung gesture, carbuncle future sore.

Rhizoma Dioscoreae Nipponicae: property is flat, bitter in the mouth.Control cough, rheumatic arthritis, Kaschin-Beck disease arthralgia, dyspepsia, malaria, traumatic injury, carbuncle malignant boil.Have relaxing muscles and tendons to promote blood circulation, the diuretic that helps digestion, the preventing the attack (or recurrence) of malaria function of eliminating the phlegm.

Herba Taxilli: hardship, sweet, property is flat.Enter liver, kidney channel.Main incised wound, goes numbness, woman's metrorrhagia, internal injury deficiency, puerperal remaining disease, lower milk.The heat that disappears, nourishing, chases after wind.The heat radiation of nourishing blood, makes tea-drinking, relaxing muscles and tendons and activating QI and blood in the collateral.Can invigorating the liver and kidney, bone and muscle strengthening, wind-damp dispelling, antiabortive.Main soreness of waist and knee joint; A little less than muscles and bones flaccidity; Limbs are hemiplegia; Rheumatic arthralgia; Head is wrong dizzy; Frequent fetal movement, metrostaxis.For rheumatic arthralgia, soreness of the waist and knees, muscles and bones is unable, and metrorrhagia warp is many, blood leaking in gestation, frequent fetal movement; Hypertension.

Os Draconis: sweet puckery, flat; Enter the heart, liver, kidney, large intestine channel.By pathogen, tranquilizing mind, only cold-dysentery and defecation with blood and pus, woman's metrorrhagia leukorrhagia, only essence is let out in dream, and sexual intercourse in dream, controls hematuria, void and diverse and confused adding of dreaminess and use it.Spleen invigorating, astringing intestine to stop diarrhea stomach, antidiarrheal dysentery, thirsty disease, the conceived tire that leaks, discharging fresh blood stool, metrorrhagia leukorrhagia, serious epistaxis, spits blood, hidroschesis.Function tranquillization with heavy prescription tranquillizing the mind by relieving convulsion, arresting sweating controlling nocturnal emission with astringent drugs, hemostasis astringing intestine to stop diarrhea, promoting tissue regeneration and ulcer healing.Control infantile convulsion demented, palpitation with a distress feeling is forgetful, insomnia and dreamful sleep, and spontaneous sweating, seminal emission stranguria with turbid discharge, tells nosebleed and has blood in stool, bleeding not during menses, dysentery proctoptosis, ulcer does not close up for a long time.

Concha Margaritifera: salty, cold.Return liver, heart channel.Liver nourishing the moon, clearing away liver-fire.Control demented infantile convulsion, dizziness, tinnitus, heart beating, pleuroperitoneum is swollen, women's heat in blood, metrorrhagia, frightened the jerking of children's sent out convulsion.Suppressing the hyperactive liver, YANG hyperactivity suppressing, arresting convulsion, hemostasis.Control dizziness, tinnitus, cardiopalmus, insomnia, demented, infantile convulsion, spits blood, epistaxis, metrorrhagia.

Concha Erosariae seu Cypraeae: salty, flat.Return Liver Channel.Tang Materia Medica: " improving eyesight, poison reduces phlegm and internal heat." " decoction pieces is newly joined ": " clear away heart-fire, suppressing the hyperactive liver is calmed the nerves, and controls frightened cautious sleeplessness." suppressing the hyperactive liver and subsiding YANG, tranquillizing the mind by relieving convulsion, liver heat removing and eyesight improving.For excessive rising of liver-YANG, have a dizzy spell, palpitation with fear insomnia, conjunctival congestion cataracta, blurred vision dim eyesight.Can be antipyretic, reduce vascular permeability, anti-liver injury etc.

Herba Apocyni veneti: sweetness and bitterness, cool." Shaanxi Chinese herbal medicine ": " refrigerant pathogenic fire purging, heart tonifying diuresis, blood pressure lowering.Control heart disease, hypertension, neurasthenia, nephritis edema." relieve inflammation or internal heat, blood pressure lowering, heart tonifying, diuresis.Control heart disease, hypertension, neurasthenia, hepatitis abdominal distention, nephritis edema.

Ramulus Uncariae Cum Uncis: sweet, hardship, is slightly cold; Enter Liver Channel, heart channel." detailed outline ": " the large number of people revolves dizzy, suppressing liver-wind, and except heat in the heart, children's's infantile tic stomachache, sends out macule." Tang Materia Medica: " Ramulus Uncariae Cum Uncis goes out Liang Zhou.Leaf is elongated, and spinosity between stem, if shape fishhook person." function heat clearing away suppressing the hyperactive liver, relieving spasm by subduing liver-wind.Cure mainly infantile convulsion, night cry, intenseness of heat wind symptom, eclamposia, dizziness due to hyperactivity of liver-YANG, liver-fire distending pain in the head.

Bombyx Batryticatus: salty, pungent, flat; Return liver, lung, stomach warp.Shennong's Herbal: " main pediatric epilepsy scared, night cry, go three worms, goes out black, makes us complexion good, the cloudy infections disease of man." Compendium of Material Medica: " erysipelas is had an itch for loose wind-phlegm tuberculosis, scrofula, wind syndrome of head, wind worm toothache, skin wind skin ulcer.”

Indigo Naturalis: salty, cold.Return Liver Channel.Heat-clearing and toxic substances removing, removing heat from blood, arresting convulsion.For maculae caused by violent heat pathogen, heat in blood is told nosebleed, chest pain hemoptysis, aphtha, mumps, sore throat, pediatric epilepsy scared.

Semen Setariae italicae: light; Be slightly cold.Return large intestine; Spleen; Kidney; Urinary bladder channel.Eliminating damp-heat.Main edema; Dysuria; Vexed; Thirsty; Dysentery; Eczema; Furuncle.

Le Amaranthus mangostanus L.: sweet; Cold nature.Cooling blood for hemostasis; Eliminating damp-heat; Removing toxicity for eliminating carbuncles.Main gastrorrhagia; Have blood in stool; Hemorrhoidal bleeding; Cholecystitis; Cholelithiasis; Dysentery; Diarrhea due to damp-heat; Leukorrhagia; Difficulty and pain in micturition; Laryngopharynx swelling and pain; Eczema; Carbuncle; Gingiva erosion; Venom.

Herba Sedi: sweet, light, cool.Return liver, gallbladder, small intestine meridian.Eliminating damp-heat, removing toxic substances.For jaundice due to damp-heat, dysuria, carbuncle skin infection, acute hepatitis, chronic hepatitis.

The invention provides one and treat the hypertensive Chinese medicine of flaming-up of the liverfire type, comprise following raw medicinal material: Spica Prunellae, Semen Cassiae, Flos Buddlejae, Flos Eriocauli, Semen Celosiae, Radix Gentianae, Flos Chrysanthemi Indici, Rhizoma Bistortae, Radix Puerariae, Radix Gentianae Macrophyllae, Radix Stephaniae Tetrandrae, Ramulus Mori, Herba Siegesbeckiae, Folium et Ramulus Clerodendri Trichotomi, Retinervus Luffae Fructus, Rhizoma Dioscoreae Nipponicae, Herba Taxilli, Os Draconis, Concha Margaritifera, Concha Erosariae seu Cypraeae, Herba Apocyni veneti, Ramulus Uncariae Cum Uncis, Bombyx Batryticatus, Indigo Naturalis, Semen Setariae italicae, le Amaranthus mangostanus L. and Herba Sedi.

Wherein, in Chinese medicine, the ratio of weight and number of each raw medicinal material is preferably: 15～30 parts of Spica Prunellaes, 13～27 parts of Semen Cassiaes, 11～25 parts of Flos Buddlejaes, 22～36 parts of Flos Eriocaulis, 23～38 parts of Semen Celosiae, 12～24 parts of Radix Gentianae, 16～29 parts of Flos Chrysanthemi Indicis, 30～40 parts of Rhizoma Bistortaes, 16～27 parts of Radix Puerariaes, 18～33 parts of Radix Gentianae Macrophyllae, 15～31 parts of Radixs Stephaniae Tetrandrae, 20～35 parts of Ramulus Moris, 18～33 parts of Herba Siegesbeckiaes, 10～25 parts of Folium et Ramulus Clerodendri Trichotomis, 13～29 parts of Retinervus Luffae Fructuss, 12～25 parts of Rhizoma Dioscoreae Nipponicae, 13～29 parts of Herba Taxillis, 18～30 parts of Os Draconis, 12～28 parts of Concha Margaritiferas, 11～26 parts of Concha Erosariae seu Cypraeae, 20～35 parts of Herba Apocyni venetis, 10～22 parts of Ramulus Uncariae Cum Uncis, 15～28 parts of Bombyx Batryticatus, 7～18 parts of Indigo Naturaliss, 15～30 parts of Semen Setariae italicaes, 14～27 parts of 23～36 parts of le Amaranthus mangostanus L.s and Herba Sedis.

Wherein, in Chinese medicine, the ratio of weight and number of each raw medicinal material can also be preferably: 18～28 parts of Spica Prunellaes, 15～23 parts of Semen Cassiaes, 13～22 parts of Flos Buddlejaes, 25～31 parts of Flos Eriocaulis, 23～30 parts of Semen Celosiae, 14～22 parts of Radix Gentianae, 17～26 parts of Flos Chrysanthemi Indicis, 30～38 parts of Rhizoma Bistortaes, 17～25 parts of Radix Puerariaes, 19～31 parts of Radix Gentianae Macrophyllae, 16～28 parts of Radixs Stephaniae Tetrandrae, 23～32 parts of Ramulus Moris, 19～32 parts of Herba Siegesbeckiaes, 11～24 parts of Folium et Ramulus Clerodendri Trichotomis, 14～25 parts of Retinervus Luffae Fructuss, 14～24 parts of Rhizoma Dioscoreae Nipponicae, 16～28 parts of Herba Taxillis, 19～26 parts of Os Draconis, 14～23 parts of Concha Margaritiferas, 12～23 parts of Concha Erosariae seu Cypraeae, 24～35 parts of Herba Apocyni venetis, 11～21 parts of Ramulus Uncariae Cum Uncis, 17～25 parts of Bombyx Batryticatus, 7～14 parts of Indigo Naturaliss, 15～25 parts of Semen Setariae italicaes, 15～25 parts of 23～33 parts of le Amaranthus mangostanus L.s and Herba Sedis.

Wherein, in Chinese medicine, the ratio of weight and number of each raw medicinal material is by being preferably: 18 parts of Spica Prunellaes, 17 parts of Semen Cassiaes, 22 parts of Flos Buddlejaes, 28 parts of Flos Eriocaulis, 23 parts of Semen Celosiae, 19 parts of Radix Gentianae, 23 parts of Flos Chrysanthemi Indicis, 35 parts of Rhizoma Bistortaes, 25 parts of Radix Puerariaes, 31 parts of Radix Gentianae Macrophyllae, 28 parts of Radixs Stephaniae Tetrandrae, 30 parts of Ramulus Moris, 19 parts of Herba Siegesbeckiaes, 13 parts of Folium et Ramulus Clerodendri Trichotomis, 25 parts of Retinervus Luffae Fructuss, 19 parts of Rhizoma Dioscoreae Nipponicae, 16 parts of Herba Taxillis, 26 parts of Os Draconis, 17 parts of Concha Margaritiferas, 21 parts of Concha Erosariae seu Cypraeae, 35 parts of Herba Apocyni venetis, 19 parts of Ramulus Uncariae Cum Uncis, 17 parts of Bombyx Batryticatus, 14 parts of Indigo Naturaliss, 22 parts of Semen Setariae italicaes, 15 parts of 26 parts of le Amaranthus mangostanus L.s and Herba Sedis.

Wherein, in Chinese medicine, the ratio of weight and number of each raw medicinal material can also be preferably: 28 parts of Spica Prunellaes, 23 parts of Semen Cassiaes, 13 parts of Flos Buddlejaes, 31 parts of Flos Eriocaulis, 30 parts of Semen Celosiae, 22 parts of Radix Gentianae, 17 parts of Flos Chrysanthemi Indicis, 38 parts of Rhizoma Bistortaes, 17 parts of Radix Puerariaes, 26 parts of Radix Gentianae Macrophyllae, 16 parts of Radixs Stephaniae Tetrandrae, 32 parts of Ramulus Moris, 32 parts of Herba Siegesbeckiaes, 24 parts of Folium et Ramulus Clerodendri Trichotomis, 20 parts of Retinervus Luffae Fructuss, 14 parts of Rhizoma Dioscoreae Nipponicae, 28 parts of Herba Taxillis, 19 parts of Os Draconis, 23 parts of Concha Margaritiferas, 12 parts of Concha Erosariae seu Cypraeae, 24 parts of Herba Apocyni venetis, 21 parts of Ramulus Uncariae Cum Uncis, 25 parts of Bombyx Batryticatus, 8 parts of Indigo Naturaliss, 15 parts of Semen Setariae italicaes, 25 parts of 23 parts of le Amaranthus mangostanus L.s and Herba Sedis.

Wherein, in Chinese medicine, the ratio of weight and number of each raw medicinal material also can be preferably: 20 parts of Spica Prunellaes, 15 parts of Semen Cassiaes, 19 parts of Flos Buddlejaes, 25 parts of Flos Eriocaulis, 29 parts of Semen Celosiae, 14 parts of Radix Gentianae, 26 parts of Flos Chrysanthemi Indicis, 30 parts of Rhizoma Bistortaes, 21 parts of Radix Puerariaes, 19 parts of Radix Gentianae Macrophyllae, 22 parts of Radixs Stephaniae Tetrandrae, 23 parts of Ramulus Moris, 23 parts of Herba Siegesbeckiaes, 11 parts of Folium et Ramulus Clerodendri Trichotomis, 14 parts of Retinervus Luffae Fructuss, 24 parts of Rhizoma Dioscoreae Nipponicae, 27 parts of Herba Taxillis, 25 parts of Os Draconis, 14 parts of Concha Margaritiferas, 23 parts of Concha Erosariae seu Cypraeae, 32 parts of Herba Apocyni venetis, 11 parts of Ramulus Uncariae Cum Uncis, 19 parts of Bombyx Batryticatus, 7 parts of Indigo Naturaliss, 25 parts of Semen Setariae italicaes, 21 parts of 33 parts of le Amaranthus mangostanus L.s and Herba Sedis.

Step 3: step 2 Chinese medicine slag is added to 4-6 times of water gaging and soak 1-2.5 hour, extract 1 time, extracting 1.5-2 hour thickening filtration is extractum shape, is component 2;

Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure of reaching technique effect can fully understand and implement according to this.

Embodiment 1 honey refining of the present invention pill

Get Spica Prunellae 18g, Semen Cassiae 17g, Flos Buddlejae 22g, Flos Eriocauli 28g, Semen Celosiae 23g, Radix Gentianae 19g, Flos Chrysanthemi Indici 23g, Rhizoma Bistortae 35g, Radix Puerariae 25g, Radix Gentianae Macrophyllae 31g, Radix Stephaniae Tetrandrae 28g, Ramulus Mori 30g, Herba Siegesbeckiae 19g, Folium et Ramulus Clerodendri Trichotomi 13g, Retinervus Luffae Fructus 25g, Rhizoma Dioscoreae Nipponicae 19g, Herba Taxilli 16g, Os Draconis 26g, Concha Margaritifera 17g, Concha Erosariae seu Cypraeae 21g, Herba Apocyni veneti 35g, Ramulus Uncariae Cum Uncis 19g, Bombyx Batryticatus 17g, Indigo Naturalis 14g, Semen Setariae italicae 22g, le Amaranthus mangostanus L. 26g and Herba Sedi 15g.

Its preparation method comprises the following steps:

Step 2: get again surplus stock medical material and mix in described ratio, add 90% soak with ethanol 1 hour, heating extraction 2 times with respect to 3 times of amounts of mixture, each 1 hour, merge extractive liquid,, 140 orders filter, be 4400 ultrafiltration post ultrafiltration again through the molecular weight that dams, the extractum that when ultrafiltrate is evaporated to 87 DEG C, relative density is 1.04, becomes component 1;

Step 3: step 2 Chinese medicine slag is added to 4-6 times of water gaging and soak 1 hour, extract 1 time, extracting 2 hours thickening filtrations is extractum shape, is component 2;

Embodiment 2 granule of the present invention

Get Spica Prunellae 28g, Semen Cassiae 23g, Flos Buddlejae 13g, Flos Eriocauli 31g, Semen Celosiae 30g, Radix Gentianae 22g, Flos Chrysanthemi Indici 17g, Rhizoma Bistortae 38g, Radix Puerariae 17g, Radix Gentianae Macrophyllae 26g, Radix Stephaniae Tetrandrae 16g, Ramulus Mori 32g, Herba Siegesbeckiae 32g, Folium et Ramulus Clerodendri Trichotomi 24g, Retinervus Luffae Fructus 20g, Rhizoma Dioscoreae Nipponicae 14g, Herba Taxilli 28g, Os Draconis 19g, Concha Margaritifera 23g, Concha Erosariae seu Cypraeae 12g, Herba Apocyni veneti 24g, Ramulus Uncariae Cum Uncis 21g, Bombyx Batryticatus 25g, Indigo Naturalis 8g, Semen Setariae italicae 15g, le Amaranthus mangostanus L. 23g and Herba Sedi 25g.

Its preparation method comprises the following steps:

Step 1: described raw medicinal material is mixed in described ratio, the ethanol that to add with respect to the determining alcohol of 4 times, mixture be 85%, be heated to boiling reflux 3 hours, filter, adopt the speed slowly percolation of percolation with 1ml per minute, collect percolate, the mastic that while being evaporated to 60 DEG C subsequently under vacuum 0.07Mpa, relative density is 1.04, spraying is dry, 160 DEG C of the inlet temperature of spray dryer, 80 DEG C of leaving air temps, be ground into subsequently powder, make dried cream powder;

Step 2: in the dried cream powder obtaining, add with respect to the cane sugar powder of 0.2 times of dried cream powder quality and the dextrin of 0.1 times, granulation, in 50 DEG C dry, obtain granule.

Embodiment 3 is of the present invention containing tablet

Get Spica Prunellae 20g, Semen Cassiae 15g, Flos Buddlejae 19g, Flos Eriocauli 25g, Semen Celosiae 29g, Radix Gentianae 14g, Flos Chrysanthemi Indici 26g, Rhizoma Bistortae 30g, Radix Puerariae 21g, Radix Gentianae Macrophyllae 19g, Radix Stephaniae Tetrandrae 22g, Ramulus Mori 23g, Herba Siegesbeckiae 23g, Folium et Ramulus Clerodendri Trichotomi 11g, Retinervus Luffae Fructus 14g, Rhizoma Dioscoreae Nipponicae 24g, Herba Taxilli 27g, Os Draconis 25g, Concha Margaritifera 14g, Concha Erosariae seu Cypraeae 23g, Herba Apocyni veneti 32g, Ramulus Uncariae Cum Uncis 11g, Bombyx Batryticatus 19g, Indigo Naturalis 7g, Semen Setariae italicae 25g, le Amaranthus mangostanus L. 33g and Herba Sedi 21g.

Its preparation method comprises the following steps:

The first step, mixes Spica Prunellae, Semen Cassiae, Flos Buddlejae, Flos Eriocauli, Semen Celosiae, Radix Gentianae and Flos Chrysanthemi Indici in described ratio, use the soak with ethanol with respect to the determining alcohol 95% of 6 times of the mixture quality obtaining, and reflux was extracted after 3 hours, filters; Filtering residue is used to the soak with ethanol with respect to the determining alcohol 95% of 3 times of the mixture quality obtaining again, and reflux was extracted after 2 hours, filtered; Merge filtrate twice, decompression recycling ethanol to be concentrated into liquor strength be 1.2g crude drug/mL, utilize twice of the macroporous adsorptive resins eluting that volume is 5L, first use deionized water or the distilled water eluting of 5 times of resin column volumes, be 95% ethanol elution with the determining alcohol of 3 times of resin column volumes again, collect ethanol elution, concentrating under reduced pressure is removed ethanol, is dried and is ground into powder;

Second step, Rhizoma Bistortae, Radix Puerariae, Radix Gentianae Macrophyllae, Radix Stephaniae Tetrandrae, Ramulus Mori, Herba Siegesbeckiae, Folium et Ramulus Clerodendri Trichotomi and Retinervus Luffae Fructus are mixed in described ratio, add with respect to obtain mixture quality the determining alcohol 95% of 4 times alcohol heating reflux extract 2 times, extracted twice liquid merges, with the centrifugal remove impurity of tube centrifuge, the mastic that when extracting solution after remove impurity is evaporated to 60 DEG C under the condition of 70 DEG C, relative density is 1.20, is dried to powder by the mastic after concentrated with spray dryer;

The 3rd step, mixes surplus stock medical material in described ratio, add the water soaking of 3 times with respect to the mixture quality obtaining, and heating decocts 3 hours, filters; Filtering residue is used to the water soaking of 3 times with respect to the mixture quality obtaining again, and heating decocts 2 hours, filters; Merge filtrate twice, concentrating under reduced pressure is removed moisture, is dried and is ground into powder;

The 4th step, the powder that the first step, second step and the 3rd step are obtained mixes, further add with respect to the carboxymethyl starch sodium of 0.1 times of the mixture quality obtaining, the microcrystalline Cellulose of 0.1 times, mix, granulate, after being dried, add the magnesium stearate with respect to 0.05 times of the mixture quality obtaining, then with decompressor, granule is suppressed in flakes, obtained containing tablet.

The invention provides one and treat the hypertensive Chinese medicine of flaming-up of the liverfire type, form of Chinese drug can be: tablet, sugar coated tablet, film coated tablet, enteric coated tablet, capsule, hard capsule, soft capsule, oral liquid, containing tablet, granule, electuary, honey pill agent, powder, sublimed preparation, solution, injection, suppository, plaster, syrup, powder, liniment, enema and patch.

Chinese medicine is decocted in use decoction and is taken, and 1 dose of every day, decocting takes at twice, within every 10 days, is a course for the treatment of; In the time that this Chinese medicine composition is drop use, 4 times on the one every 7 days is a course for the treatment of; When this Chinese medicine composition be capsule, honey pill agent, granule, while using containing tablet, 2 times on the one, every 9 days is a course for the treatment of.

Toxicity test:

Acute toxicity test: 60 of application NIH mices, SPF level, male and female half and half, body weight 17～24g, carries out acute toxicity test.Mice is divided into two groups at random, and 20 every group, i.e. matched group and administration group, fasting 12 hours before experiment; Granule prepared by embodiments of the invention 2 is dissolved in water, (concentration is 5.74g crude drug/ml, maximum concentration) gavage, gavage volume is that 5ml/kg(is that single-dose dosage is 28.7 crude drugs/kg), matched group gives equivalent normal saline, administration in a day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Experimental result shows: with matched group comparison, after administration, mice has no notable difference, experiment Continuous Observation 14 days, and mice overall health of patients, diet, drinking-water, body weight gain are all normal.Mice oral administration gavage granule LD50>28.7 of the present invention crude drug/kg, every day, maximum dosage-feeding was 57.4 crude drugs/kg/ day.Chinese medicine clinical application amount of the present invention is 4.6g crude drug/day/people, becomes body weight for humans in 60KG, and average dosage is 0.077g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is taking 21g) oral administration gavage Chinese medicine of the present invention is 745 times of quantity.Therefore Chinese medicine acute toxicity of the present invention is low, clinical drug safety.

Long term toxicity test: by the embodiment of the present invention 3 containing tablet to mice by 6.43,15.72 and 16 weeks (1.0ml/100g body weight of 36.41g crude drug/kg continuous use, every day 2 times) and drug withdrawal after 4 weeks, result shows: the index such as the hair of Chinese medicine preparation of the present invention to mice, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat all has no significant effect, internal organs naked eyes do not find that difference changes and histological examination result shows, medication 16 weeks and drug withdrawal are after 4 weeks, and Organs of Mice is all without obviously changing.Illustrate that toxicity is little after Chinese medicine preparation of the present invention is to mice long-term prescription, after drug withdrawal, also there is no difference reaction, application safety.

Long term toxicity test: by the honey refining pill of the embodiment of the present invention 1 to mice by 6.43,15.72 and 16 weeks (1.0ml/100g body weight of 36.41g crude drug/kg continuous use, every day 2 times) and drug withdrawal after 4 weeks, result shows: the index such as the hair of Chinese medicine preparation of the present invention to mice, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat all has no significant effect, internal organs naked eyes do not find that difference changes and histological examination result shows, medication 16 weeks and drug withdrawal are after 4 weeks, and Organs of Mice is all without obviously changing.Illustrate that toxicity is little after Chinese medicine preparation of the present invention is to mice long-term prescription, after drug withdrawal, also there is no difference reaction, application safety.

Clinical data:

Case selection: the flaming-up of the liverfire type hypertensive patient of anthology institute man 103 examples, female's 97 examples, age distribution: 26-65 year.Be divided at random four groups:

Honey refining pill treatment group: 50 people, male 25 people, female 25 people; 27～64 years old age, average (51.33 ± 6.35) year, the course of disease (5.60 ± 4.35) year, merges coronary heart disease 18 examples, hyperlipemia 20 examples, diabetes 12 examples;

Granules in Treating group: 50 people, male 26 people, female 24 people; 26～63 years old age, average (52.03 ± 7. 05) year, the course of disease (5.70 ± 4.15) year, merges coronary heart disease 20 examples, hyperlipemia 18 examples, diabetes 12 examples;

Contain tablet treatment group: 50 people, male 26 people, female 24 people; 28～63 years old age average (51.22 ± 6. 77) year, the course of disease (5.40 ± 4.60) year, merges coronary heart disease 19 examples, hyperlipemia 21 examples, diabetes 10 examples.

Western medicine group: 50 people, male 26 people, female 24 people, 28～65 years old age, average (51.82 ± 7. 17) year, the course of disease (5. 40 ± 4.55) year, merges coronary heart disease 20 examples, hyperlipemia 20 examples, diabetes 10 examples.

Four groups at equal not statistically significants of aspect difference (P > 0. 05) such as sex, age, the course of disease, Body Mass Index and complication, has comparability.

Diagnostic criteria:

The diagnosis of hypertension is with reference to the Evaluation of Diagnostic Criteria of Hypertension of WHO/ISH, and Chinese medical discrimination is with reference to the dialectical standard of " new Chinese medicine Hypertension guideline of clinical investigations " syndrome of liver fire flaring up.

Therapeutic Method:

Honey refining pill treatment group: the honey refining pill that uses the embodiment of the present invention 1 to prepare, 2 times on the one, one time 4, every 10 days is a course for the treatment of;

Granules in Treating group: the granule that uses the embodiment of the present invention 2 to prepare, 2 times on the one, a 15g, every 10 days is a course for the treatment of;

Containing tablet treatment group: use prepared by the embodiment of the present invention 3 containing tablet, 2 times on the one, one time 4, every 10 days is a course for the treatment of;

Matched group: take Bezoar pill for lowering blood pressure, Darentang Traditional Chinese Medicine Factory, Tianjin produces, and every ball weighs 1. 6g, each 2 balls, every day 2 or 3 times, every 10 days is a course for the treatment of.

Four groups of period in a medicine must not use other antihypertensive drug and measure.

The standard of curative effect evaluation:

The Chinese hypertension prevention and control guide new standard that criterion of therapeutical effect is announced taking " traditional Chinese medical science disease Standardization of diagnosis and curative effect " and 2004 is as foundation.

Effective: systolic pressure/diastolic pressure≤130/85 mmHg, do not use other depressor, continue not rebound for 3 months, meanwhile, other is followed clinical symptom disappearance or alleviates, and life can take care of oneself completely;

Effective: hypertension is controlled at I level hyperpietic (except original I level hypertension case) above by II level; systolic pressure/diastolic pressure is controlled at 135/85 mmHg-150/90 mmHg; do not use other depressor; continue not rebound for 3 months; simultaneously; other is followed clinical symptom disappearance or alleviates, and life can take care of oneself completely;

Invalid: hypertension through treatment still the above person of II level, systolic pressure/diastolic pressure >=160/100 mmHg, other follows clinical symptoms to be not improved.

Therapeutic outcome:

Referring to table 1 and table 2, as can be seen from Table 1, adopt treatment by Chinese herbs flaming-up of the liverfire type hypertension of the present invention, on therapeutic effect, there is significant improvement with respect to Western medicine; As can be seen from Table 2, adopt treatment by Chinese herbs flaming-up of the liverfire type hypertension of the present invention, with respect to Western medicine, treating significantly shortening on the course for the treatment of.

Four groups, table 1 is treated respectively Clinical efficacy comparison example after 30 days

Group	Number of cases	Effective	Effectively	Invalid	Effective and effective percentage
						Honey refining pill treatment group	50	31	18	1	98.0%
Granules in Treating group	50	30	18	2	96.0%
						Containing tablet treatment group	50	29	19	2	96.0%
Matched group	50	12	20	18	64.0%

Four groups, table 2 is treated respectively effective after 30 days and efficiently individual quantity and time comparative example (%)

Group	Number of cases	1-10 days	11-20 days	21-30 days
					Honey refining pill treatment group	49	9(18.4%)	24(49.0%)	16(32.7%)
Granules in Treating group	48	10(20.8%)	23(47.9%)	15(31.3%)
					Containing tablet treatment group	48	10(20.8%)	22(45.8%)	16(33.3%)
Matched group	32	3(9.4%)	12(37.5%)	17(53.1%)

Known according to the clinical statistics in above table, that Chinese medicine provided by the invention has is rapid-action, effective percentage is high, determined curative effect, safe, the advantage that has no side effect; Simultaneously to effective and effective 49 examples of honey refining pill, effective and effective 48 examples of Granules in Treating group, contain effective and effective 48 examples of tablet treatment group and the effective and effective 32 routine patients of matched group follow up a case by regular visits to 1 year, result is added up:

Effective and effective 49 examples of honey refining pill, 31 effective routine 1 case relapseds, 1 case relapsed in effective 18 routine patients, relapse rate is 4.1%;

Effective and effective 48 examples of Granules in Treating group, 30 effective routine 1 case relapseds, 1 case relapsed in effective 18 routine patients, relapse rate is 4.2%;

Containing effective and effective 48 examples of tablet treatment group, 29 effective routine 1 case relapseds, 1 case relapsed in effective 19 routine patients, relapse rate is 4.2%;

Effective and effective 32 examples of western medicine group, 12 effective example recurrence 2 examples, recur 4 examples in effective 20 routine patients, and relapse rate is 18.8%.

Model case: Zhang, man, 55 years old.In August, 2013 is medical.Patient's readme hypertension history more than 10 years, once took the medicines such as blood pressure lowering, and blood pressure still continues at 140/95 mmHg-160/110mmHg; Conscious headache and dizzy, red eyes and bitter taste in the mouth, distending pain in the chest and hypochondrium, is insomnia, irritated irritability, yellow urine, constipation with dry stool, symptom increased the weight of gradually over the past two years, red tongue with yellow fur, wiry and frequent pulse.Electrocardiogram report left ventricular hypertrophy, X Pian Shi heart circle expands left.Be diagnosed as hypertension, Chinese medical discrimination flaming-up of the liverfire type.The honey refining pill of taking Chinese medicine preparation embodiment 1 of the present invention, 1 dose of every day, serve on 2 courses for the treatment of, blood pressure drops, and all diseases disappear.Advise it to continue to take medicine 1 course for the treatment of, further consultation after February, blood pressure stabilization, at 120/80 mmHg, is followed up a case by regular visits to 1 year, and all diseases have no recurrence.

The foregoing is only preferred embodiment of the present invention, in order to limit the present invention, within the spirit and principles in the present invention not all, any amendment of doing, be equal to replacement, improvement etc., within all should being included in protection scope of the present invention.

Claims

1. the hypertensive Chinese medicine for the treatment of flaming-up of the liverfire type, it is characterized in that, comprise following raw medicinal material: Spica Prunellae, Semen Cassiae, Flos Buddlejae, Flos Eriocauli, Semen Celosiae, Radix Gentianae, Flos Chrysanthemi Indici, Rhizoma Bistortae, Radix Puerariae, Radix Gentianae Macrophyllae, Radix Stephaniae Tetrandrae, Ramulus Mori, Herba Siegesbeckiae, Folium et Ramulus Clerodendri Trichotomi, Retinervus Luffae Fructus, Rhizoma Dioscoreae Nipponicae, Herba Taxilli, Os Draconis, Concha Margaritifera, Concha Erosariae seu Cypraeae, Herba Apocyni veneti, Ramulus Uncariae Cum Uncis, Bombyx Batryticatus, Indigo Naturalis, Semen Setariae italicae, le Amaranthus mangostanus L. and Herba Sedi.

2. Chinese medicine as claimed in claim 1, it is characterized in that, in described Chinese medicine, the ratio of weight and number of each raw medicinal material is: 15～30 parts of Spica Prunellaes, 13～27 parts of Semen Cassiaes, 11～25 parts of Flos Buddlejaes, 22～36 parts of Flos Eriocaulis, 23～38 parts of Semen Celosiae, 12～24 parts of Radix Gentianae, 16～29 parts of Flos Chrysanthemi Indicis, 30～40 parts of Rhizoma Bistortaes, 16～27 parts of Radix Puerariaes, 18～33 parts of Radix Gentianae Macrophyllae, 15～31 parts of Radixs Stephaniae Tetrandrae, 20～35 parts of Ramulus Moris, 18～33 parts of Herba Siegesbeckiaes, 10～25 parts of Folium et Ramulus Clerodendri Trichotomis, 13～29 parts of Retinervus Luffae Fructuss, 12～25 parts of Rhizoma Dioscoreae Nipponicae, 13～29 parts of Herba Taxillis, 18～30 parts of Os Draconis, 12～28 parts of Concha Margaritiferas, 11～26 parts of Concha Erosariae seu Cypraeae, 20～35 parts of Herba Apocyni venetis, 10～22 parts of Ramulus Uncariae Cum Uncis, 15～28 parts of Bombyx Batryticatus, 7～18 parts of Indigo Naturaliss, 15～30 parts of Semen Setariae italicaes, 14～27 parts of 23～36 parts of le Amaranthus mangostanus L.s and Herba Sedis.

3. Chinese medicine as claimed in claim 1 or 2, it is characterized in that, in described Chinese medicine, the ratio of weight and number of each raw medicinal material is: 18～28 parts of Spica Prunellaes, 15～23 parts of Semen Cassiaes, 13～22 parts of Flos Buddlejaes, 25～31 parts of Flos Eriocaulis, 23～30 parts of Semen Celosiae, 14～22 parts of Radix Gentianae, 17～26 parts of Flos Chrysanthemi Indicis, 30～38 parts of Rhizoma Bistortaes, 17～25 parts of Radix Puerariaes, 19～31 parts of Radix Gentianae Macrophyllae, 16～28 parts of Radixs Stephaniae Tetrandrae, 23～32 parts of Ramulus Moris, 19～32 parts of Herba Siegesbeckiaes, 11～24 parts of Folium et Ramulus Clerodendri Trichotomis, 14～25 parts of Retinervus Luffae Fructuss, 14～24 parts of Rhizoma Dioscoreae Nipponicae, 16～28 parts of Herba Taxillis, 19～26 parts of Os Draconis, 14～23 parts of Concha Margaritiferas, 12～23 parts of Concha Erosariae seu Cypraeae, 24～35 parts of Herba Apocyni venetis, 11～21 parts of Ramulus Uncariae Cum Uncis, 17～25 parts of Bombyx Batryticatus, 7～14 parts of Indigo Naturaliss, 15～25 parts of Semen Setariae italicaes, 15～25 parts of 23～33 parts of le Amaranthus mangostanus L.s and Herba Sedis.

4. the Chinese medicine as described in as arbitrary in claim 1-3, it is characterized in that, in described Chinese medicine, the ratio of weight and number of each raw medicinal material is: 18 parts of Spica Prunellaes, 17 parts of Semen Cassiaes, 22 parts of Flos Buddlejaes, 28 parts of Flos Eriocaulis, 23 parts of Semen Celosiae, 19 parts of Radix Gentianae, 23 parts of Flos Chrysanthemi Indicis, 35 parts of Rhizoma Bistortaes, 25 parts of Radix Puerariaes, 31 parts of Radix Gentianae Macrophyllae, 28 parts of Radixs Stephaniae Tetrandrae, 30 parts of Ramulus Moris, 19 parts of Herba Siegesbeckiaes, 13 parts of Folium et Ramulus Clerodendri Trichotomis, 25 parts of Retinervus Luffae Fructuss, 19 parts of Rhizoma Dioscoreae Nipponicae, 16 parts of Herba Taxillis, 26 parts of Os Draconis, 17 parts of Concha Margaritiferas, 21 parts of Concha Erosariae seu Cypraeae, 35 parts of Herba Apocyni venetis, 19 parts of Ramulus Uncariae Cum Uncis, 17 parts of Bombyx Batryticatus, 14 parts of Indigo Naturaliss, 22 parts of Semen Setariae italicaes, 15 parts of 26 parts of le Amaranthus mangostanus L.s and Herba Sedis.

5. the Chinese medicine as described in as arbitrary in claim 1-3, it is characterized in that, in described Chinese medicine, the ratio of weight and number of each raw medicinal material is: 28 parts of Spica Prunellaes, 23 parts of Semen Cassiaes, 13 parts of Flos Buddlejaes, 31 parts of Flos Eriocaulis, 30 parts of Semen Celosiae, 22 parts of Radix Gentianae, 17 parts of Flos Chrysanthemi Indicis, 38 parts of Rhizoma Bistortaes, 17 parts of Radix Puerariaes, 26 parts of Radix Gentianae Macrophyllae, 16 parts of Radixs Stephaniae Tetrandrae, 32 parts of Ramulus Moris, 32 parts of Herba Siegesbeckiaes, 24 parts of Folium et Ramulus Clerodendri Trichotomis, 20 parts of Retinervus Luffae Fructuss, 14 parts of Rhizoma Dioscoreae Nipponicae, 28 parts of Herba Taxillis, 19 parts of Os Draconis, 23 parts of Concha Margaritiferas, 12 parts of Concha Erosariae seu Cypraeae, 24 parts of Herba Apocyni venetis, 21 parts of Ramulus Uncariae Cum Uncis, 25 parts of Bombyx Batryticatus, 8 parts of Indigo Naturaliss, 15 parts of Semen Setariae italicaes, 25 parts of 23 parts of le Amaranthus mangostanus L.s and Herba Sedis.

6. the Chinese medicine as described in as arbitrary in claim 1-3, it is characterized in that, in described Chinese medicine, the ratio of weight and number of each raw medicinal material is: 20 parts of Spica Prunellaes, 15 parts of Semen Cassiaes, 19 parts of Flos Buddlejaes, 25 parts of Flos Eriocaulis, 29 parts of Semen Celosiae, 14 parts of Radix Gentianae, 26 parts of Flos Chrysanthemi Indicis, 30 parts of Rhizoma Bistortaes, 21 parts of Radix Puerariaes, 19 parts of Radix Gentianae Macrophyllae, 22 parts of Radixs Stephaniae Tetrandrae, 23 parts of Ramulus Moris, 23 parts of Herba Siegesbeckiaes, 11 parts of Folium et Ramulus Clerodendri Trichotomis, 14 parts of Retinervus Luffae Fructuss, 24 parts of Rhizoma Dioscoreae Nipponicae, 27 parts of Herba Taxillis, 25 parts of Os Draconis, 14 parts of Concha Margaritiferas, 23 parts of Concha Erosariae seu Cypraeae, 32 parts of Herba Apocyni venetis, 11 parts of Ramulus Uncariae Cum Uncis, 19 parts of Bombyx Batryticatus, 7 parts of Indigo Naturaliss, 25 parts of Semen Setariae italicaes, 21 parts of 33 parts of le Amaranthus mangostanus L.s and Herba Sedis.

7. the Chinese medicine as described in as arbitrary in claim 1-6, is characterized in that, when the dosage form of described Chinese medicine is honey refining pill, its preparation method comprises the following steps:

8. the Chinese medicine as described in as arbitrary in claim 1-6, is characterized in that, when the dosage form of described Chinese medicine is granule, its preparation method comprises the following steps:

9. a preparation method for the arbitrary described Chinese medicine of claim 1-6, is characterized in that, the dosage form of described Chinese medicine is for containing tablet, and its preparation method comprises the following steps: