CN104162133A - Composition for removing acne - Google Patents
Composition for removing acne Download PDFInfo
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- CN104162133A CN104162133A CN201410408777.1A CN201410408777A CN104162133A CN 104162133 A CN104162133 A CN 104162133A CN 201410408777 A CN201410408777 A CN 201410408777A CN 104162133 A CN104162133 A CN 104162133A
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- sesamin
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Abstract
The invention relates to a composition for removing acne. The composition is prepared by uniformly mixing gingko flavonoid powder extracted from ginkgo leaves, sesamin powder extracted from sesame and ginger oil extracted from ginger in a mass ratio of (1-2):(1-2):(1-2); the content of gingko flavonoids in the gingko flavonoid powder is greater than 50%; the content of sesamin in the sesamin powder is greater than 50%; and the content of gingerol in the ginger oil is greater than 20%. The composition and a drug excipient are mixed so as to obtain external preparations for skin, such as cream emulsions, gel, and the like. Pharmacological studies show that the external preparations prepared according to the invention have an effect of treating staphylococcus aureus and propionibacterium acnes induced acne animal models, and also can inhibit the generation of acne marks. Clinical trials show that the composition disclosed by the invention has a significant acne treatment effect, the effective rate is 100%, and the composition is safe in use and has side effect.
Description
Technical field
The invention belongs to biomedicine field, be specifically related to the external preparation for anti-acne, be i.e. a kind of ginkgetin of natural origin, sesamin and oil of Rhizoma Zingiberis Recens compositions.
Background technology
Acne is commonly called as pox, comedo, is the one of infectious skin disease, how to be caused by propionibacterium acnes or infection of staphylococcus aureus.Acne is outbreak repeatedly easily, and due to the multiple face of being born in, facial skin lesion or pox print and affect appearance, bring misery to patient, affect patient's physical and mental health.Acne treatment mostly is anti-bacterial drug at present, though these medicines have effect for the moment, prolonged application can cause many side effect; And application antibiotic therapy can not suppress, and pox prints and the generation of cicatrix.For fear of the generation of this type of bad phenomenon, market demand develop derive from natural, effect significantly, without the Novel external preparation of the Acne treatment of obvious adverse reaction, to alleviate patient's physiology and mental anguish.Patients with acne is numerous, and the external preparation product of therefore developing this type of Acne treatment has a good application prospect, and is very useful and necessary to patient.
Semen Ginkgo is the medicinal plants of China's preciousness, and leaf, fruit and the episperm etc. of Semen Ginkgo all have medicinal exploitation and are worth.Record according to Compendium of Material Medica, Semen Ginkgo property is sweet, bitter, flat, puckery; Have that relieving asthma and cough, leukorrhagia stopping are turbid, the merit of pain relieving; Cure mainly cough of cold type phlegm dyspnea, asthma, frequent micturition, leucorrhea with red and white discharge, rhagadia manus et pedis etc.In Semen Ginkgo, contain the multiple components that natural activity flavone and terpene lactones etc. are useful with health, there is the skin of improvement microcirculation, blood vessel dilating, reduction serum cholesterol, improve cardiovascular and cerebrovascular circulation, protection central nervous system, antiviral, inhibiting bacteria and diminishing inflammation, the multiple effect such as anticancer; Wherein ginkgetin is main active component.In Semen Sesami, contain oils and fats, protein, polysaccharide, trace element, vitamin, sesamin etc., wherein sesamin is the major function composition in Semen Sesami, and molecular formula is C
20h
18o
6, belong to lignanoids; Sesamin has the interior free yl of elimination, reduces serum cholesterol, and liver function protecting, promotes alcohol metabolism, and the multiple physiological active functions such as antibacterial activity, can be applicable to health food and field of medicaments.Rhizoma Zingiberis Recens is a kind of important flavouring agent, is also the health plant resource of the traditional integration of edible and medicinal herbs in Asia, has the multiple effects such as cold relieving, damp eliminating, warming the stomach stomach invigorating, relaxing muscles and tendons to promote blood circulation, antiinflammatory.Oil of Rhizoma Zingiberis Recens contains the multiple material with nutrition health-care functions, and as gingerol, zingiberol, zingiberone, zingiberene, gingerol compounds, oil of Rhizoma Zingiberis Recens has market prospect very widely in fields such as food, cosmetics, health product, medicines.Ginkgetin, sesamin and oil of Rhizoma Zingiberis Recens combination, have the collaborative advantage that strengthens pharmacologically active, can improve better function separately, produced unforeseeable technique effect; Three's combination, not only evident in efficacy, effect is better than anti-acne medicine conventional on market, but the side effect that antibiotic-free brings and the easily shortcoming of generation drug resistance.Have no ginkgetin, sesamin and the oil of Rhizoma Zingiberis Recens compatibility report for the purposes of anti-acne.
Summary of the invention
The object of this invention is to provide a kind of compositions with anti-acne effect, it is characterized in that, the mixed with excipients of itself and medicine is made preparation for external application to skin, and it has the function of anti-acne, have evident in efficacy, use safe feature.
The present invention to Folium Ginkgo extract obtain ginkgetin powder, Semen Sesami extract obtain sesamin powder, Rhizoma Zingiberis Recens extracts and obtains oil of Rhizoma Zingiberis Recens, 1-2:1-2:1-2 mix homogeneously obtains having the compositions of anti-acne effect in mass ratio.Best mass ratio is 1:1:1.Flavonoid of ginkgo biloba in ginkgetin powder is greater than 50%, and the sesamin content in sesamin powder is greater than 50%; Gingerol content in oil of Rhizoma Zingiberis Recens is greater than 20%.Said composition can become preparation for external application to skin by known processes, as cream frost emulsion, gel, pad pasting, subcutaneous injection agent etc.
Ginkgetin, sesamin, oil of Rhizoma Zingiberis Recens in the present invention's formula, all have significant antibacterial and antiinflammatory action.The invention has the beneficial effects as follows, ginkgetin, sesamin, oil of Rhizoma Zingiberis Recens three combination can be worked in coordination with enhancing physiologically active, improve better antiinflammatory anti-infective function separately, have produced unforeseeable technique effect.Pharmacological testing shows, external preparation of the present invention has the effect of the acne animal model that treatment staphylococcus aureus, propionibacterium acnes bring out, and effective fast, effect is better than anti-acne medicine conventional on market, but can not bring the side effect and the easy shortcoming that produces drug resistance that use antibiotic to produce.What is more important, ginkgetin, sesamin, oil of Rhizoma Zingiberis Recens three combination, can suppress the generation of pox seal and cicatrix, and this is very important for patients with acne.The research of local irritation test safety evaluatio shows safety of the present invention, without the untoward reaction such as skin irritation, allergy, application safety.Clinic trial result shows, the present invention has significant anti-acne effect, and effective percentage reaches 100%, uses safety to have no side effect.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is further described.
Embodiment 1:
A kind of compositions with anti-acne effect is made up of the ginkgetin powder extracting from Folium Ginkgo, the sesamin powder extracting from Semen Sesami, the oil of Rhizoma Zingiberis Recens mix homogeneously that extracts from Rhizoma Zingiberis Recens, 1:1:1 mix homogeneously composition in mass ratio.
Ginkgetin powder extraction process is as follows: Folium Ginkgo is pulverized, with 70% alcohol heating reflux extraction, merge extractive liquid,, cross membrance separation, reclaim ethanol and be concentrated in right amount, being added on processed good AB-8 macroporous adsorbent resin the ethanol elution of water and variable concentrations successively, collect corresponding eluent, be condensed into extractum, vacuum drying, weighs, obtain ginkgetin powder, and measure the content (mg/g) of ginkgetin.This product character is: sundown powder, and odorless, mildly bitter flavor, has hygroscopicity, is dissolved in alcohol, water insoluble.
Flavonoid of ginkgo biloba is measured: adopt HPLC method to measure., filter the dissolving of ginkgetin powder with dehydrated alcohol (chromatographically pure).At column temperature: room temperature; Mobile phase: methanol-0.4% phosphoric acid solution (50:50); Flow velocity 0.8ml/min; Sample size: 20 μ l; Detect wavelength 360nm.Carry out qualitatively according to the retention time of standard specimen, calculate the content of ginkgetin by external standard method.This product flavonoid of ginkgo biloba is 510.03mg/g.
The preparation technology of ginkgetin powder and content assaying method are public method.
The preparation technology of sesamin powder is as follows: by sesame seed meal grind into powder, add the normal hexane of approximately 2 times of volumes to stir defat, 3h when dimension, adds the normal hexane of approximately 2 times of volumes to carry out defat for the second time again after filtration, and 3h when dimension is air-dry.Accurately take a certain amount of powder, add solid-liquid ratio 1:8.5(g/ml) 93% ethanol, at 55 DEG C of bath temperatures, stir, extraction time 2.5h, repeats to extract once.Extracting liquid filtering steams filtrate part ethanol on Rotary Evaporators, concentrating under reduced pressure, and in 60 DEG C of vacuum dryings, weigh, obtain sesamin powder, and measure the content (mg/g) of sesamin.This product character is: light brown powder, and odorless, tasteless, there is hygroscopicity, be dissolved in alcohol, water insoluble.
Sesamin assay: adopt HPLC method to measure.The standard solution of sesamin is between 20-100 μ g/ml, and respective peaks area and sesamin mass concentration have significant linear relationship, have worked out standard curve., filter sesamin powder dissolution with dehydrated alcohol.At column temperature: room temperature; Mobile phase: methanol-water (8:2, v/v); Flow velocity 0.8ml/min; Sample size: 20 μ l; Detect wavelength 290nm; Analysis time: measure sesamin content in this product under 15min condition.Carry out qualitatively according to the retention time of standard specimen, calculate the content of sesamin by external standard method.This product sesamin content is 536.19mg/g.
Sesamin extraction process and content assaying method are public method.
The preparation technology of oil of Rhizoma Zingiberis Recens is as follows: get Rhizoma Zingiberis Recens, section, crushed after being dried are cleaned in peeling.Add 70% alcohol reflux 2 times, add for the first time 10 times of amounts, extract 90min; Add 8 times of amounts the 2nd time, extract 60min, merge ethanol extract, filter, the concentrated ethanol to the greatest extent that steams of filtrate decompression, obtains oil of Rhizoma Zingiberis Recens, and measures the content (mg/g) of gingerol.This product character is: light yellow oil, there is acid, and be dissolved in alcohol, water insoluble.
Gingerol assay: adopt HPLC method to measure., filter oil of Rhizoma Zingiberis Recens dissolving with dehydrated alcohol (chromatographically pure).At column temperature: room temperature; Mobile phase: acetonitrile-methanol-water (40:5:55); Flow velocity 0.8ml/min; Sample size: 20 μ l; Detect wavelength 280nm.Carry out qualitatively according to the retention time of standard specimen, calculate the content of gingerol by external standard method.This product gingerol content is 233.97mg/g.
The preparation technology of oil of Rhizoma Zingiberis Recens and content assaying method are public method.
The preparation of gel: carbopol 10g is sprinkled upon to 500ml distilled water surface, swelling spending the night.Take glycerol 60g, propylene glycol 120ml, is added to respectively in swelling good carbopol, grinds evenly rapidly, obtains transparent gel-type vehicle.Get above-mentioned ginkgetin powder, sesamin powder and oil of Rhizoma Zingiberis Recens, be dissolved in 100ml 95% alcoholic solution, be slowly added in gel-type vehicle, stir.Slowly add again triethanolamine 15ml, mend distilled water to enough 1000 g, obtain light yellow gel 1000 g.Be sub-packed in 50 tubules every 20 g.Every gram of gel composition containing ginkgo flavone+sesamin+oil of Rhizoma Zingiberis Recens is 40mg+40mg+40mg.
Gel preparation technology is public method.
Embodiment 2:
A kind of compositions with anti-acne effect is made up of the ginkgetin powder extracting from Folium Ginkgo, the sesamin powder extracting from Semen Sesami, the oil of Rhizoma Zingiberis Recens mix homogeneously that extracts from Rhizoma Zingiberis Recens, 1:2:1 mix homogeneously composition in mass ratio.
The preparation of ointment: get above-mentioned ginkgetin powder, sesamin powder and oil of Rhizoma Zingiberis Recens, be dissolved in 100ml 95% alcoholic solution, then add wherein triethanolamine 50ml, heat to 70 DEG C.Paraffin 300g, stearic acid 300g, propylene glycol 100ml are added respectively to stir and melt, mend distilled water to enough 1000 g, stir to paste, obtain faint yellow ointment 1000 g.Be sub-packed in 50 tubules every 20 g.Every gram of ointment composition containing ginkgo flavone+sesamin+oil of Rhizoma Zingiberis Recens is 40mg+80mg+40mg.
Ointment preparation technology is public method.
The other the same as in Example 1.
Embodiment 3:
A kind of compositions with anti-acne effect is made up of the ginkgetin powder extracting from Folium Ginkgo, the sesamin powder extracting from Semen Sesami, the oil of Rhizoma Zingiberis Recens mix homogeneously that extracts from Rhizoma Zingiberis Recens, 1:1:2 mix homogeneously composition in mass ratio.
The preparation of tincture: get above-mentioned ginkgetin powder, sesamin powder and oil of Rhizoma Zingiberis Recens, be dissolved in 600ml 95% alcoholic solution, then add respectively wherein triethanolamine 50ml, propylene glycol 200ml stirs, mend 95% alcoholic solution to enough 1000 ml, obtain faint yellow tincture 1000 ml.Be sub-packed in 50 tubules every 20 ml.Every milliliter of tincture composition containing ginkgo flavone+sesamin+oil of Rhizoma Zingiberis Recens is 20mg+20mg+40mg.
Tincture preparation technology is public method.
The other the same as in Example 1.
The external preparation of making in order to top method, carries out relevant pharmacology pharmacodynamic test, the experiment of local irritation safety evaluatio and clinic trial test.Experimental data of the present invention below:
Zoopery one:
Staphylococcus aureus collecting cells: staphylococcus aureus is inoculated in to broth bouillon, shaken cultivation 24 h in 37 DEG C of air, centrifugal liquid culture medium, with the normal saline flushing bacterium colony of sterilizing 2 times, after centrifugal, with sterile saline, staphylococcus aureus is made to bacteria suspension again, according to plate count result respectively compound concentration be 1.0 × 10
5, 1.0 × 10
6, 1.0 × 10
7with 1.0 × 10
8the bacterial suspension of CFU/mL, 4 DEG C save backup.
The foundation of infection of staphylococcus aureus animal model: 90 Kunming mouses are divided into 9 groups at random, are respectively model control group, ginkgetin group, sesamin group, Rhizoma Zingiberis Recens line of oils, ginkgetin+sesamin group, ginkgetin+Rhizoma Zingiberis Recens line of oils, sesamin+Rhizoma Zingiberis Recens line of oils, of the present invention group, positive controls.Every group of mouse back right side shaved off to hair with shaver, expose skin.Subcutaneous injection staphylococcus aureus bacteria suspension 1.0 × 10
6cFU/mL, 0.1mL.Injection staphylococcus aureus bacteria suspension, after 2 days, is respectively organized the mouse infection position corresponding external preparation of outer painting respectively, and positive controls mouse skin infection site is smeared antimicrobial ointment Mupirocin Ointment, and model control group mouse skin infection site is smeared ethanol; Every day 1 time, continuous 6 days.
Detect index: infecting mouse skin lesion area detects: subcutaneous injection staphylococcus aureus the 2nd, 4,6 days, with hyaline membrane covering laboratory animal skin infection position, trace, cut film along infection site edge, analytical balance takes quality transformed area.Skin scoring: put to death before animal, the skin of skin infection mice is carried out to sensory evaluation scores, the score by rules of infection of staphylococcus aureus model is in table 1.
Experimental result is in table 2, table 3.Result shows, compared with Normal group, external preparation of the present invention can obviously reduce infection of staphylococcus aureus mice skin lesion area and cutaneous sense scoring, effectively treats skin infection symptom.Ginkgetin, sesamin, oil of Rhizoma Zingiberis Recens three combine and are obviously better than alone and wherein both combinations, have synergism.Three's combined effect strengthens greatly, and has produced unforeseeable technique effect, as acted on time of occurrence early, effective fast; Aspect cutaneous sense Score index, be better than positive control drug antimicrobial ointment Mupirocin Ointment; And in experiment, find that the present invention can promote the formation of skin crust and come off, can reduce the formation that later stage pox prints.
The scoring of table 1 infection of staphylococcus aureus mouse model skin
| Response strength | Score value |
| Without erythema | 0 |
| Slight crust | 1 |
| Moderate erythema is without crust | 2 |
| Severe erythema is accompanied slight crust | 3 |
| Severe erythema companion severe crust | 4 |
The variation of table 2 infection of staphylococcus aureus mice skin lesion area
N=10, x ± s, compared with model control group,
*p < 0.05,
*p < 0.01. compared with of the present invention group,
# p<0.05,
## p<0.01.
Table 3 infection of staphylococcus aureus model mice cutaneous sense scoring experimental result
N=10. digitized representation animal number of elements in form.
Zoopery two:
Collecting cells: propionibacterium acnes: propionibacterium acnes is inoculated in No. 1053 culture medium, shaken cultivation 18h in 37 DEG C of air, centrifugal liquid culture medium, with the normal saline flushing bacterium colony of sterilizing 2 times, after centrifugal, with sterile saline, propionibacterium acnes is made to bacteria suspension again, according to plate count result respectively compound concentration be 1.0 × 10
5, 1.0 × 10
6, 1.0 × 10
7with 1.0 × 10
8the bacterial suspension of CFU/mL, 4 DEG C save backup.
The foundation of propionibacterium acnes infected animal model: 90 Golden Hamster are divided into 9 groups at random, are respectively model control group, ginkgetin group, sesamin group, Rhizoma Zingiberis Recens line of oils, ginkgetin+sesamin group, ginkgetin+Rhizoma Zingiberis Recens line of oils, sesamin+Rhizoma Zingiberis Recens line of oils, of the present invention group, positive controls.Right side, every group of suslik back is shaved off to hair with shaver, expose skin.Subcutaneous injection propionibacterium acnes bacteria suspension 1.0 × 10
6cFU/mL, 0.1mL.Injection propionibacterium acnes bacteria suspension is after 2 days, each group suslik infection site corresponding external preparation of outer painting respectively, the medicine Viaminate dimension E emulsifiable paste of conventional Acne treatment is smeared at positive controls suslik skin infection position, and ethanol is smeared at model control group suslik skin infection position; Every day 1 time, continuous 6 days.
Detect index: infect suslik skin lesion area and detect: subcutaneous injection propionibacterium acnes the 2nd, 4,6 days, with hyaline membrane covering laboratory animal skin infection position, trace, cut film along infection site edge, analytical balance takes quality transformed area.Skin scoring: put to death before animal, the skin of skin infection suslik is carried out to sensory evaluation scores, the score by rules of propionibacterium acnes infection model is in table 4.
Experimental result is in table 5, table 6.Result shows, compared with Normal group, external preparation of the present invention can obviously reduce propionibacterium acnes and infect Golden Hamster skin lesion area and cutaneous sense scoring, effectively Acne treatment skin infection symptom.Ginkgetin, sesamin, oil of Rhizoma Zingiberis Recens three combine and are obviously better than alone and wherein both combinations, have synergism.Three's combined effect strengthens greatly, and has produced unforeseeable technique effect, as antibacterial action with aspect cutaneous sense Score index, is better than positive control drug; And in experiment, find that the present invention can reduce keratinization material and form, promote skin aging horny layer to come off, can reduce the formation that later stage pox prints.
The scoring of table 4 propionibacterium acnes infection model Golden Hamster skin
| Response strength | Score value (level) |
| Without acne | 0 |
| The visible a small amount of fine and close keratinization material of infundibulum of hair follicle portion, and extend to sebaceous gland | + |
| The fine and close keratinization material of the visible moderate of infundibulum of hair follicle portion, and extend to sebaceous gland | ++ |
| In expansion hair follicle, there is keratinization material widely, similar to mankind's open comedones | +++ |
The variation of table 5 propionibacterium acnes infection model Golden Hamster skin lesion area
N=10, x ± s, compared with model control group,
*p < 0.05,
*of the present invention group of p < 0.01. compared with other each group,
# p<0.05,
## p<0.01.
Table 6 propionibacterium acnes infection model Golden Hamster cutaneous sense scoring experimental result
N=10. digitized representation animal number of elements in form.
Zoopery three: local irritation test
Get 8 of adult rabbit, male and female half and half, every animal sub-cage rearing, first raises 3-4 days at laboratory condition.Then rabbit spinal column both sides dorsal body setae is shaved off to every lateral area 5 × 10cm with electric shaver-for women
2.Carefully check that whether depilation district has redness and damage, if any abandoning it, can not test.Adopt the test method of multiple dosing, in depilation, anti-acne of the present invention compositions external preparation is smeared in district, every day 2 times, gives continuously 7 days.Whether last gives to wash away baste with warm water after 24 hours, observes local skin reaction respectively at l, after 24,48,72 hours, as erythema, edema, desquamation, incrustation etc., have petechia, skin peptide coarse or poor etc., records time of origin and regression time.Result shows, during smearing the present invention continuously and drug withdrawal 3 days, each rabbit skin does not all show obvious skin irritation and anaphylaxis.Show product safety of the present invention, have no adverse reaction.
Clinic trial test: the compositions external preparation of making in order to top method, on probation through patients with acne, all patients are coated with acne sufferer skin lesion place outward with the present invention, every day 1 time, at every turn appropriate; It within 5 days, is a course for the treatment of; Patient does not all use any other external preparation for skin medicine during treating.Criterion of therapeutical effect: cure: clinical skin acne disease damage performance all disappears; Effective: the basic disappearance of clinical skin acne disease damage performance, skin lesion area reducing >60%; Effective: clinical skin lesion performance part disappears, skin lesion area reducing >30%; Invalid: clinical skin lesion performance is constant or increase the weight of skin lesion area reducing < 30%.Cure rate=healing number/total case X100%; Effective percentage=(healing number+effective number+efficiently individual quantity)/total case X100%.The results are shown in Table 7.Clinic trial result shows, patients with acne is used present composition external preparation all effective, and effective percentage reaches 100%; Cure rate is 92%.During application the present invention, all there is not the untoward reaction such as skin irritation, allergy in all patients.Therefore the present invention is a kind of desirable anti-acne compositions external preparation, evident in efficacy, safe and reliable.
The clinical effectiveness of table 7 present composition external preparation anti-acne
The present invention is compared with prior art: ginkgetin, sesamin and oil of Rhizoma Zingiberis Recens three combination, there is the collaborative advantage that strengthens pharmacologically active, and improve better antiinflammatory anti-infective function separately, produce unforeseeable technique effect; Three's combination, not only anti-acne is evident in efficacy, use safety, and effect is better than anti-acne medicine conventional on market, but the side effect that antibiotic-free brings and the easy shortcoming that produces drug resistance.What is more important, ginkgetin, sesamin, oil of Rhizoma Zingiberis Recens three combination, can suppress in anti-acne that pox prints and the generation of cicatrix, and this is very important for patients with acne, is also that the product for resolving poxes commonly used is in the market not available; Therefore the present invention has good potential applicability in clinical practice.
Claims (3)
1. an anti-acne compositions, is characterized in that: by ginkgetin powder, sesamin powder and oil of Rhizoma Zingiberis Recens in mass ratio 1-2:1-2:1-2 mix homogeneously form;
Described ginkgetin powder is by extracting in Folium Ginkgo, and wherein flavonoid of ginkgo biloba is greater than 50%;
Described sesamin powder is by extracting in Semen Sesami, and wherein sesamin content is greater than 50%;
Described oil of Rhizoma Zingiberis Recens is by extracting in Rhizoma Zingiberis Recens, and wherein gingerol content is greater than 20%.
2. a kind of anti-acne compositions according to claim 1, is characterized in that: described ginkgetin powder, sesamin powder and oil of Rhizoma Zingiberis Recens be 1:1:1 mix homogeneously composition in mass ratio.
3. a kind of anti-acne compositions according to claim 1, can make preparation for external application to skin with the mixed with excipients of make-up preparation or medicine.
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| CN201410408777.1A CN104162133A (en) | 2014-08-20 | 2014-08-20 | Composition for removing acne |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410408777.1A CN104162133A (en) | 2014-08-20 | 2014-08-20 | Composition for removing acne |
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| CN104162133A true CN104162133A (en) | 2014-11-26 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115144504A (en) * | 2022-07-20 | 2022-10-04 | 北京市农林科学院 | Method for qualitatively and quantitatively detecting sesamin as special component of sesame oil |
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| CN115144504A (en) * | 2022-07-20 | 2022-10-04 | 北京市农林科学院 | Method for qualitatively and quantitatively detecting sesamin as special component of sesame oil |
| CN115144504B (en) * | 2022-07-20 | 2023-07-25 | 北京市农林科学院 | Method for qualitatively and quantitatively detecting sesamin component of sesame oil |
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