CN104159596B - 用于抗血管生成和癌症治疗的α5β1的拮抗剂的给药 - Google Patents

用于抗血管生成和癌症治疗的α5β1的拮抗剂的给药 Download PDF

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CN104159596B
CN104159596B CN201280070464.9A CN201280070464A CN104159596B CN 104159596 B CN104159596 B CN 104159596B CN 201280070464 A CN201280070464 A CN 201280070464A CN 104159596 B CN104159596 B CN 104159596B
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vlo4
antagonist
administration
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combination
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CN104159596A (zh
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冯晓东
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California Northstate College of Pharmacy LLC
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California Northstate College of Pharmacy LLC
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1767—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1891—Angiogenesic factors; Angiogenin

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Pathology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201280070464.9A 2011-12-22 2012-12-18 用于抗血管生成和癌症治疗的α5β1的拮抗剂的给药 Active CN104159596B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13/374,369 2011-12-22
US13/374,369 US8946159B2 (en) 2011-12-22 2011-12-22 Administration of an antagonist of α5β1 for anti-angiogenesis and cancer treatment
PCT/US2012/070399 WO2013096335A1 (en) 2011-12-22 2012-12-18 Administration of an antagonist of alpha 5 beta 1 for anti-antiogenesis and cancer treatment

Publications (2)

Publication Number Publication Date
CN104159596A CN104159596A (zh) 2014-11-19
CN104159596B true CN104159596B (zh) 2017-03-08

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CN201280070464.9A Active CN104159596B (zh) 2011-12-22 2012-12-18 用于抗血管生成和癌症治疗的α5β1的拮抗剂的给药

Country Status (5)

Country Link
US (6) US8946159B2 (enExample)
EP (2) EP3777877B1 (enExample)
JP (1) JP6224615B2 (enExample)
CN (1) CN104159596B (enExample)
WO (1) WO2013096335A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110319335A1 (en) 2010-06-23 2011-12-29 Xiaodong Feng Combined administration of integrin receptor antagonists for anti-angiogenic therapy
US8946159B2 (en) 2011-12-22 2015-02-03 California Northstate College Of Pharmacy, Llc Administration of an antagonist of α5β1 for anti-angiogenesis and cancer treatment
EP3182988A4 (en) * 2014-08-22 2018-05-23 National Cheng Kung University Disintegrin variants and pharmaceutical uses thereof
CA3092345A1 (en) 2018-03-13 2019-09-19 The Regents Of The University Of California Inhibitors of integrin alpha 2 beta 1 and methods of use
WO2021222789A1 (en) 2020-05-01 2021-11-04 The Regents Of The University Of California Inhibitors of alpha 2 beta 1 integrin and methods of use thereof
US12245355B2 (en) 2021-02-19 2025-03-04 Mevion Medical Systems, Inc. Gantry for a particle therapy system

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1933851A (zh) * 2004-03-24 2007-03-21 Pdl生物制药股份有限公司 使用抗－α5β1抗体抑制癌细胞增殖
US20080267978A1 (en) * 2006-08-28 2008-10-30 Mary Zutter Anti-angiogenic targets for cancer therapy

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AU3734693A (en) 1992-03-17 1993-10-21 Board Of Regents, The University Of Texas System Neurotrophic peptides
DK1075277T4 (da) * 1998-05-08 2012-12-17 Univ California Fremgangsmåder til detektion og inhibering af angiogenese
US6852318B1 (en) * 1998-05-08 2005-02-08 The Regents Of The University Of California Methods for detecting and inhibiting angiogenesis
EP1259595B1 (en) * 2000-02-25 2007-04-04 Immunex Corporation Integrin antagonists
US20040121031A1 (en) 2002-12-09 2004-06-24 Muhammed Majeed Novel topical skin care and nutraceutical applications of Glabridin or extracts containing a defined amount (4-90%) of Glabridin
US7101707B2 (en) 2002-12-23 2006-09-05 Cedars-Sinai Medical Center Secondary sprouting for isolation and expansion of endothelial sprout cells and endothelial precursor cells from a mixed population and for screening substances
ATE531388T1 (de) 2004-03-24 2011-11-15 Abbott Biotherapeutics Corp Verwendung von anti-alpha5beta1-antikörpern zur hemmung der krebszellproliferation
WO2006133338A1 (en) * 2005-06-07 2006-12-14 The Trustees Of The University Of Pennesylvania INHIBITORS OF THE α2β1/GPIa-IIa INTEGRIN
WO2007083949A1 (en) 2006-01-19 2007-07-26 Eyegene Inc. Pharmaceutical composition for treating vascular-related diseases comprising peptide
JP2009530382A (ja) 2006-03-23 2009-08-27 シェーリング コーポレイション Ｈｃｖプロテアーゼインヒビターとｃｙｐ３ａ４インヒビターとの組み合わせ、および関連する処置方法
US8008256B2 (en) * 2006-05-01 2011-08-30 University Of Southern California Combination therapy for treatment of cancer
WO2009114776A2 (en) 2008-03-14 2009-09-17 Visen Medical, Inc. Integrin targeting agents and methods of using same
US20100105644A1 (en) 2008-10-27 2010-04-29 The Regents Of The University Of Michigan Botanical composition for enhanced skin repair and uses thereof
CN102215856B (zh) 2008-12-01 2014-03-05 莱拉制药用品私营有限责任公司 用于炎症、皮肤病、粘膜病以及其它相关疾病治疗的外用制剂
WO2011146842A1 (en) 2010-05-20 2011-11-24 Temple University - Of The Commonwealth System Of Higher Education Process for synthesis of silane dipeptide analogs
US20110311335A1 (en) * 2010-06-21 2011-12-22 Douglas Wike Removable fastener
US20110319335A1 (en) * 2010-06-23 2011-12-29 Xiaodong Feng Combined administration of integrin receptor antagonists for anti-angiogenic therapy
IL210587A0 (en) 2011-01-12 2011-03-31 Adel Jamil Hidmi Natural preparation for treatment of skin sores and lesions
US8946159B2 (en) 2011-12-22 2015-02-03 California Northstate College Of Pharmacy, Llc Administration of an antagonist of α5β1 for anti-angiogenesis and cancer treatment

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1933851A (zh) * 2004-03-24 2007-03-21 Pdl生物制药股份有限公司 使用抗－α5β1抗体抑制癌细胞增殖
US20080267978A1 (en) * 2006-08-28 2008-10-30 Mary Zutter Anti-angiogenic targets for cancer therapy

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Fibronectin-mediated upregulation of α5β1 integrin and cell adhesion during differentiation of mouse embryonic stem cells;Pimchanok Pimton 等;《Cell Adhesion & Migration》;20111231;第5卷(第1期);第73-82 *
整合素及其拮抗剂的研究进展;孙沛等;《中国药业》;20071231;第16卷(第11期);第1-3页 *

Also Published As

Publication number Publication date
JP6224615B2 (ja) 2017-11-01
US20200397856A1 (en) 2020-12-24
US11318184B2 (en) 2022-05-03
US20130165380A1 (en) 2013-06-27
EP2793924A1 (en) 2014-10-29
CN104159596A (zh) 2014-11-19
US10722555B2 (en) 2020-07-28
US20130225495A1 (en) 2013-08-29
US12053504B2 (en) 2024-08-06
EP2793924B1 (en) 2020-11-04
US8946159B2 (en) 2015-02-03
JP2015506352A (ja) 2015-03-02
US8815805B2 (en) 2014-08-26
US20220226431A1 (en) 2022-07-21
WO2013096335A8 (en) 2014-03-27
HK1203391A1 (en) 2015-10-30
US20240342240A1 (en) 2024-10-17
EP3777877A1 (en) 2021-02-17
EP3777877B1 (en) 2024-08-07
WO2013096335A1 (en) 2013-06-27
EP2793924A4 (en) 2015-08-26
US20150105320A1 (en) 2015-04-16

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