CN104138637A - Small remote-control light-sensation gene stimulating device and control method of small remote-control light-sensation gene stimulating device - Google Patents
Small remote-control light-sensation gene stimulating device and control method of small remote-control light-sensation gene stimulating device Download PDFInfo
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Abstract
The invention provides a small remote-control light-sensation gene stimulating device and a control method of the small remote-control light-sensation gene stimulating device. The small remote-control light-sensation gene stimulating device comprises a central processing unit, a radio frequency module, a switch driving circuit, a digital potentiometer, an automatic power control circuit, an excitement light source, a photosensitive diode, a voltage stabilizing module and a power source. The radio frequency module receives an external instruction and transmits the external instruction to the central processing unit, the switch driving circuit controls the excitement light source to be turned on and turned off to form light pulses, the digital potentiometer changes the static working current of the photosensitive diode to accordingly control the initial power of the excitement light source, the photosensitive diode receives light output by the excitement light source and converts the light into a light current, and the light current is fed back to the automatic power control circuit for feedback adjustment on the outlet light power to achieve stable output. The small remote-control light-sensation gene stimulating device has the advantages of being low in power consumption, small in size, high in stability, convenient to control, wide in application range and rapid in adjustment, is suitable for light-sensation gene experiments, fills in the blank of wearable light-sensation gene stimulating devices in the light gene field, and has the wide market prospects.
Description
Technical field
The invention belongs to photoelectron, microelectronics and gene optical technical field, relate to a kind of small-sized remote-controlled light sensation gene stimulating apparatus and control method thereof.
Background technology
The effect that reaches treatment by the method for electricity irritation has had the history of centuries at biology and medical domain, and the method is day by day ripe and entered clinical medical application, and wherein most typical application is implantable cardiac pacemaker.In such device, adopted microelectronic circuit to produce specific excitation, to stimulate the specific region of human body to reach the object for the treatment of.In recent years, demand for treatment nervous system disease is day by day strong, wherein so-called " brain pacemaker " is used for the treatment of the cerebral nerve disease of the types such as parkinson disease, and entered clinical practice, ultimate principle and the heart heartstart of its device are quite similar, but the controllability of paired pulses parameter is had higher requirement.Progress along with the deep and molecular biotechnology of studying, by adopting gene technology to introduce, there is bioactive photaesthesia material in biological cell and organism, utilize its light sensitive characteristic to produce attention (the Boyden E S et al.Millisecond-timescale that specific biological function has caused scientists, genetically targeted optical control of neural activity.Nature Neuroscience, 2005,8:1263-1268).Nature, through the development of 1 years, has produced a series of bioactive photaesthesia materials that have, and these materials have very strong specificity to the light of specific wavelength in solar spectrum, but the mankind are still insufficient to its understanding, urgently carry out further investigation.In addition, with photostimulation, substituting the therapeutic effect that electricity irritation reaches in current clinical medicine is also that medical circle is dreamed of.Compare with electricity irritation, photostimulation method in conjunction with photogene technology can be without implant microelectrode in specific region, even likely stimulate in vitro, avoided, fatigue problem (Chow B Y et al.High-performance genetically targetable optical neural silencing by light-driven proton pumps.Nature aging to the damage of human body brain and stimulated areas, 2010,463:98 – 102); Utilization also likely develops brand-new effect, treatment and control model to the biological photoactive substance of different wave length sensitivity, has boundless prospect.At present, these bases and clinical application research generally adopt general, more expensive experimental apparatus to build needed photostimulation function.This obviously can not meet biological study, the especially requirement of Animal Behavior Science research, thus a kind of small-sized remote-controlled light sensation gene stimulating apparatus just arises at the historic moment.
Summary of the invention
The shortcoming of prior art in view of the above, the object of the present invention is to provide a kind of small-sized remote-controlled light sensation gene stimulating apparatus and control method thereof, for solving prior art, complete the experimental apparatus that photostimulation function needs huge costliness, can not realize small low-consumption, can not meet that biological study, human body are implanted, the problem of the requirement of wearable and Animal Behavior Science research.
For achieving the above object and other relevant objects, the invention provides a kind of light sensation gene stimulating apparatus, described light sensation gene stimulating apparatus comprises:
CPU (MCU);
The wireless radio frequency modules (RFID), switch driving circuit and the digital regulation resistance that are connected with described CPU; Described wireless radio frequency modules receives external command and sends the instruction of reception to described CPU by serial ports; Described CPU is opened corresponding I/O mouth according to instruction, and gives described switch driving circuit or digital regulation resistance by bus assignment; Described CPU drives described switch driving circuit by corresponding I/O mouth output low and high level, and controls described digital regulation resistance by corresponding I/O mouth, changes the resistance of described digital regulation resistance;
The automatic power control circuitry (APC) being connected with described switch driving circuit and described digital regulation resistance, and the excited light source being connected with described automatic power control circuitry respectively and light sensitive diode (PD); Described digital regulation resistance changes the static working current of described light sensitive diode by change in resistance, thereby controls the initial power of described excited light source; Described light sensitive diode receives the light of output dorsad of described excited light source and is converted to photoelectric current, feeds back to described automatic power control circuitry; Described automatic power control circuitry carries out feedback regulation to realize out light power stabilising output to the light extraction efficiency of described excited light source;
The power supply (Power Source) being connected with described CPU, wireless radio frequency modules, switch driving circuit, digital regulation resistance, automatic power control circuitry, excited light source and light sensitive diode respectively by Voltage stabilizing module.
Alternatively, described excited light source comprises semiconductor laser, light emitting diode, optical fiber laser or adopts laser diode-pumped solid state laser.
Alternatively, described excited light source is semiconductor laser, and described light sensitive diode is integrated in described semiconductor laser.
Alternatively, the instruction that described wireless radio frequency modules receives comes from remote controller.
Alternatively, described power supply is chargeable lithium cell, and the running voltage of described excited light source is less than 10V.
Alternatively, described CPU is also connected with at least one sensor.
Alternatively, described sensor comprises one or more in velocity sensor, acceleration transducer, displacement transducer, temperature sensor, light sensor, acoustic sensor, gas sensor, flavor sensor.
Alternatively, between a plurality of described light sensation gene stimulating apparatus by described wireless radio frequency modules network consisting.
Alternatively, described wireless radio frequency modules is bluetooth module.
Alternatively, the optical pulse frequency scope being produced by described light sensation gene stimulating apparatus is 0～500Hz, and wave-length coverage is limit of visible spectrum.
Alternatively, described excited light source is connected with silica fibre, the light pulse producing for exporting described excited light source.
Alternatively, described CPU, wireless radio frequency modules, switch driving circuit, digital regulation resistance, automatic power control circuitry, excited light source and light sensitive diode are all integrated on a circuit board.
Alternatively, described CPU, wireless radio frequency modules, switch driving circuit, digital regulation resistance and automatic power control circuitry are integrated on described circuit board by surface mount mode.
Alternatively, the volume of described light sensation gene stimulating apparatus is less than 50cm
3.
Alternatively, described CPU is connected with at least two switch driving circuits, and these at least two switch driving circuits are arranged to respectively different pulse parameters, the light pulse that drives respectively different excited light sources to produce different frequency.
Alternatively, described CPU is connected with at least two switch driving circuits, the light pulse that these at least two switch driving circuits drive respectively different excited light sources to produce different wave length.
Alternatively, described CPU is only connected with a switch driving circuit, the light pulse that this switch driving circuit drives different excited light sources to produce different wave length.
Alternatively, the light pulse of different wave length or different frequency is exported respectively by different optical fiber or output simultaneously, or adopts optical fiber combiner to be exported by an optical fiber.
The present invention also provides a kind of control method of light sensation gene stimulating apparatus, and the method comprises:
By power supply and the Voltage stabilizing module that is connected in described power supply, CPU, wireless radio frequency modules, switch driving circuit, digital regulation resistance, automatic power control circuitry, excited light source and light sensitive diode are powered;
Utilize wireless radio frequency modules receive external command and send the instruction of reception to CPU by serial ports;
Described CPU is opened corresponding I/O mouth according to instruction, and by bus assignment to switch driving circuit or digital regulation resistance;
Described CPU drives described switch driving circuit by corresponding I/O mouth output low and high level, realizes conducting and the disconnection of excited light source, forms light pulse;
Described CPU is controlled described digital regulation resistance by corresponding I/O mouth, changes the size of the static working current of light sensitive diode by changing the resistance of described digital regulation resistance, thereby controls the initial power of described excited light source;
By light sensitive diode, receive the light of output dorsad of described excited light source and be converted to photoelectric current and feed back to automatic power control circuitry, utilize automatic power control circuitry to carry out feedback regulation to realize out light power stabilising output to the luminous power that goes out of described excited light source.
Alternatively, utilize the Transistor-Transistor Logic level of a part of port generation of described CPU to trigger described switch driving circuit, by software delay, control the time of low and high level, regulate described excited light source output light frequency and dutycycle.
Alternatively, by same switch driving circuit, control the light pulse that different excited light sources produces different wave length.
Alternatively, by different switch driving circuits, control the light pulse that different excited light sources produces different frequency or different wave length.
Alternatively, by different optical fiber, export respectively or export simultaneously the light pulse of different wave length or different frequency, or the light pulse by an optical fiber output different wave length or different frequency by optical fiber combiner.
Alternatively, utilize described CPU pick-up transducers data, and send data to wireless terminal, or according to data content, regulate output light frequency or the wavelength of excited light source.
Alternatively, utilize described wireless radio frequency modules by different light sensation gene stimulating apparatus network consistings, to study the photostimulation characteristic of life colony.
As mentioned above, small-sized remote-controlled light sensation gene stimulating apparatus and control method thereof of the present invention, there is following beneficial effect: (1) small-sized remote-controlled light sensation gene stimulating apparatus of the present invention adopts simple particular electrical circuit topology to realize microminiaturized micro-power consumption requirement, can meet that human body is implanted, the needs of wearable, biological study, Animal Behavior Science research; (2) pulse width covers millisecond to a second scope, and the adjustable needs that stimulate to adapt to light sensation gene cell of dutycycle numeral; (3), by sensor acquisition data and be sent to wireless terminal or regulated the output optical parameter of excited light source by CPU according to data, can be used for studying light sensation stimulates the impact on Animal Behavior Science; (4) physical circuit topology consists of small scale integration, wireless radio frequency modules, excited light source, CPU, automatic power control circuitry and switch driving circuit etc., described small scale integration is connected with power supply by Voltage stabilizing module, and other funtion part in difference connected system, to realize the design to the integration of each funtion part and locus; (5) switch adds the automatic power control circuitry can be so that excited light source is realized stable power stage in wider temperature range; (6) device can adopt packed by metal casing, has guaranteed good heat dissipation characteristics, has effectively extended the service life of excited light source; (7) wireless radio frequency modules can adopt Bluetooth technology, has very strong versatility and compatibility, can be for connecting plurality of devices, and very effectively controlled cost; (8) CPU has multichannel interface, can external multiple sensors, also can carry out multichannel control, and there is very strong extended capability, can realize intelligent monitoring; (9) device of the present invention have low in energy consumption, volume is little, stability is high, control is convenient, wide application, regulate advantage rapidly, be highly suitable for the experiment of light sensation gene, and filled up the blank of Wearable light sensation stimulating apparatus in photogene field, there is boundless market prospect.
Accompanying drawing explanation
Fig. 1 is shown as the structural representation of light sensation gene stimulating apparatus of the present invention.
Fig. 2 is shown as the schematic flow sheet of the control method of light sensation gene stimulating apparatus of the present invention.
Element numbers explanation
1 CPU
2 wireless radio frequency modules
3 switch driving circuits
4 digital regulation resistances
5 automatic power control circuitries
6 excited light sources
7 light sensitive diodes
8 Voltage stabilizing modules
9 power supplys
The specific embodiment
Below, by specific instantiation explanation embodiments of the present invention, those skilled in the art can understand other advantages of the present invention and effect easily by the disclosed content of this description.The present invention can also be implemented or be applied by the other different specific embodiment, and the every details in this description also can be based on different viewpoints and application, carries out various modifications or change not deviating under spirit of the present invention.
Refer to Fig. 1 and Fig. 2.It should be noted that, the diagram providing in the present embodiment only illustrates basic conception of the present invention in a schematic way, satisfy and only show with assembly relevant in the present invention in graphic but not component count, shape and size drafting while implementing according to reality, during its actual enforcement, kenel, quantity and the ratio of each assembly can be a kind of random change, and its assembly layout kenel also may be more complicated.
The invention provides a kind of light sensation gene stimulating apparatus, refer to Fig. 1, be shown as the structural representation of described light sensation gene stimulating apparatus, comprising:
CPU 1;
The wireless radio frequency modules 2, switch driving circuit 3 and the digital regulation resistance 4 that are connected with described CPU 1; Described wireless radio frequency modules 2 receives external command and sends the instruction of reception to described CPU 1 by serial ports; Described CPU 1 is opened corresponding I/O mouth according to instruction, and gives described switch driving circuit 3 or digital regulation resistance 4 by bus assignment; Described CPU 1 drives described switch driving circuit 3 by corresponding I/O mouth output low and high level, and controls described digital regulation resistance 4 by corresponding I/O mouth, changes the resistance of described digital regulation resistance 4;
The automatic power control circuitry 5 being connected with described switch driving circuit 3 and described digital regulation resistance 4, and the excited light source 6 and the light sensitive diode 7 that are connected with described automatic power control circuitry 5 respectively; Described digital regulation resistance 4 changes the static working current of described light sensitive diode 7 by change in resistance, thereby controls the initial power of described excited light source 6; Described light sensitive diode 7 receives the light of output dorsad of described excited light source 6 and is converted to photoelectric current, feeds back to described automatic power control circuitry 5; The light extraction efficiency of 5 pairs of described excited light sources 6 of described automatic power control circuitry carries out feedback regulation to realize out light power stabilising output;
The power supply 9 being connected with described CPU 1, wireless radio frequency modules 2, switch driving circuit 3, digital regulation resistance 4, automatic power control circuitry 5, excited light source 6 and light sensitive diode 7 respectively by Voltage stabilizing module 8.
Concrete, described excited light source 6 produces the adjustable light pulse on a large scale of pulse frequency and dutycycle by wireless remote control, and light sensation gene or light sensation neuron are stimulated.General, the optical pulse frequency scope of generation is 0～500 Hz, wave-length coverage is limit of visible spectrum.Described excited light source 6 includes but not limited to semiconductor laser, light emitting diode, optical fiber laser or adopts laser diode-pumped solid state laser etc., and its wavelength and power can need to be selected according to practical application.
Concrete, described wireless radio frequency modules 2 includes but not limited to the wireless communication modules such as bluetooth module, the instruction that described wireless radio frequency modules 2 receives comes from remote controller, and will send the instruction of reception to described CPU 1 by serial ports, realizes long distance wireless intelligent monitoring.
Concrete, the Transistor-Transistor Logic level that a part of port of described CPU 1 produces is used for triggering described switch driving circuit 3, controls the time of low and high level by software delay, realizes the adjusting of frequency and dutycycle; The resistance that the count enable pulse that another part port of described CPU 1 produces can change described digital regulation resistance 4 to be to change the static working current of described light sensitive diode 7, thereby controls the initial output of described excited light source 6.In order to obtain higher resolution, can, by thering is the 10K of 100 taps and the digital regulation resistance of two resistances of 1K is connected serially in circuit, can obtain the resolution of the highest 10 μ W.Described automatic power control circuitry 5 connects described excited light source 6 and described light sensitive diode 7, described excited light source 6 can be exported the power of 0～80mW, its photoelectric current that corresponding described photodiode 7 produces is respectively 0～1.2mA, the described light sensitive diode 7 of usining feeds back as light, utilize described automatic power control circuitry 5 can make described excited light source 6 in wider temperature range, realize stable power stage, thereby made up the deficiency of the easy temperature influence of laser instrument.Meet the requirement of scientific experiments.Described excited light source 6 is connected with silica fibre, the light pulse producing for exporting described excited light source 6.
Concrete, described power supply 9 includes but not limited to the higher portable battery of chargeable lithium cell homenergic volume ratio, easy to use.In described gene stimulating apparatus, can be provided with battery case, for accommodating described power supply 9.In view of the voltage 3.7 of conventional lithium battery and voltage are with fluctuating discharge time, and circuit part wishes to power to guarantee that by the burning voltage of 5V or other value pulse parameter is stable, therefore described power supply 9 must provide burning voltage for device through Voltage stabilizing module 8.Described power supply 9 can adopt the common AAA lithium battery in market, has good versatility, and detachably by external charger, is charged.Certainly, described power supply also can adopt other form as the lithium battery of flattening.In light sensation gene stimulating apparatus of the present invention, the running voltage of described excited light source 6 is less than 10V, can realize low-power consumption requirement.
In light sensation gene stimulating apparatus of the present invention, described CPU 1 can have multichannel interface, can carry out multichannel control, there is very strong extended capability, can as required the output light wavelength of light sensation gene stimulating apparatus be expanded to easily two kinds and more than.
Concrete, the light pulse of different wave length can be controlled and be produced by same electric pulse generator, and described CPU 1 is only connected with a switch driving circuit 3, the light pulse that this switch driving circuit 3 drives different excited light source 6 to produce different wave length.
The light pulse of different wave length also can be controlled and be produced by different electric pulse generators, be that described CPU 1 is connected with at least two switch driving circuits 3, the light pulse that these at least two switch driving circuits 3 drive respectively different excited light source 6 to produce different wave length.
Simultaneously, the light pulse of different wave length is controlled to produce by different electric pulse generators and can also be conveniently arranged to different pulse parameters, be that described CPU 1 is connected with at least two switch driving circuits 3, these at least two switch driving circuits 3 are arranged to respectively different pulse parameters, the light pulse that drives different excited light source 6 to produce different frequency.
Concrete, the light pulse of different wave length or different frequency can be exported respectively or output simultaneously by different optical fiber, also can adopt optical fiber combiner to be exported by an optical fiber.
Light sensation gene stimulating apparatus of the present invention can also external multiple sensors, comprises one or more in velocity sensor, acceleration transducer, displacement transducer, temperature sensor, light sensor, acoustic sensor, gas sensor, flavor sensor.
Concrete, described sensor is connected on the interface of described CPU 1, and can and process by described CPU 1 pick-up transducers data, sensing data can be transferred on the one hand to wireless terminal (as computer etc.), on the other hand can be according to the program having set by oneself, as output light frequency or the wavelength of excited light source 6 as described in regulating according to data content, realize different stimulations.
In addition, light sensation gene stimulating apparatus of the present invention can also utilize described wireless radio frequency modules 2 to realize networking function, utilizes described wireless radio frequency modules 2 by different light sensation gene stimulating apparatus network consistings, can be for the photostimulation characteristic of research life colony.
Light sensation gene stimulating apparatus of the present invention has that volume is little, the feature of micro-power consumption, in this device, described CPU 1, wireless radio frequency modules 2, switch driving circuit 3, digital regulation resistance 4, automatic power control circuitry 5, excited light source 6 and light sensitive diode 7 all can be integrated on a circuit board, on described circuit board, there is small scale integration, this small scale integration is connected with power supply by Voltage stabilizing module, and other funtion part in difference connected system, to realize the design to the integration of each funtion part and locus.
Concrete, described CPU 1, wireless radio frequency modules 2, switch driving circuit 3, digital regulation resistance 4 and automatic power control circuitry 5 are integrated on described circuit board by surface mount mode.Surface mounting technology (Surface Mounted Technology, SMT) be a kind of technology and technique conventional in current Electronic Assemblies industry, this technology is without to printing twist drill plug-in opening, but directly surface-assembled components and parts are pasted, are soldered to the Assembly on printing board surface assigned position, have that packing density is high, little, the lightweight feature of electronic product volume, the volume and weight of surface mount elements only has 1/10 left and right of traditional inserting element, after general employing SMT, electronic product volume-diminished 40%～60%, weight saving 60%～80%.In the present invention, the volume of described light sensation gene stimulating apparatus is less than 50cm
3, can meet that human body is implanted, the needs of wearable, biological study, Animal Behavior Science research.
As example, in the present embodiment, high 50mm, 37mm and the 30mm of being respectively of light sensation gene stimulating apparatus length and width, adopts packed by metal casing, has guaranteed good heat dissipation characteristics, has effectively extended the service life of excited light source.In this device, adopt Arduino module based on Atmel single-chip microcomputer as CPU, concrete model is Arduino pro mini, and this module is cheap, volume is little, low in energy consumption.Wireless radio frequency modules partly adopts general bluetooth module, and model is HC-06, by serial ports, connects MCU, and external command sends CPU to by bluetooth, according to instruction, opens corresponding I/O mouth, by bus assignment, gives each functional module.The I/O mouth of MCU drives take the switch driving circuit that metal-oxide-semiconductor IRF520N is core, thereby realizes conducting and the disconnection of excited light source.Meanwhile, MCU, by corresponding I/O mouth control figure potentiometer X9C103, changes the static working current of light sensitive diode by changing the resistance of digital regulation resistance, thereby controls the initial power of excited light source.The excited light source of this device has adopted semiconductor laser, its inner integrated laser diode (LD) and light sensitive diode (PD).By inner integrated LD pin and the PD pin of APC circuit while connecting laser, after being received by PD, the light of output dorsad of LD converts photoelectric current to, then feed back to APC circuit and regulate, realize the stable output of power, thereby made up the deficiency of the easy temperature influence of laser instrument.In view of the requirement of bio-light sensillary base because of stimulation time constant, repetition rate General Requirements covers several hertz to up to a hundred hertz scopes, and take the highest switching speed that can reach megahertz of Arduino module that ATmega328p single-chip microcomputer is core, can meet the requirement of light sensation gene stimulus frequency and dutycycle completely.
In the present embodiment, laser instrument is 80mW through the peak power output of optical fiber, and its corresponding drive current is 115.5mA, and voltage is 5.64V.Its energy part is supplied with by a joint rechargeable lithium battary, and its model is 10440, voltage 3.7V, capacity 600mAh.Battery is sent into booster type Voltage stabilizing module through on and off switch, and for device provides the stabilized power source of required voltage, lithium battery that this device adopts can guarantee 4 hours above stream times.This lithium battery is furnished with special-purpose battery case, and has supporting charger, after electric weight is finished, can more renew battery, has improved safety and the utilization rate of system.The minimum stimulus intensity of light sensation gene is 1mW/mm
2, and in the present embodiment, the maximum intensity through 40 μ m optical fiber outputs just can reach 6.3 * 10
4mW/mm
2so, adopt the scheme of lithium battery power supply to meet the requirement that light sensation gene stings laser power completely herein.
In the present embodiment, described switch driving circuit can supporting market on great majority with the encapsulation of TO types and the butterfly type encapsulated laser of PD pin.If transform the light emitting semiconductor device driving without PD pin as, described switch driving circuit can change bipolar transistor or the higher MOS switching device of efficiency into, adopt digital regulation resistance to control its output current, can be controlled at several mA to hundreds of mA according to concrete device.In this device, adopted blue light LD that centre wavelength is 474.7nm as excited light source, via the silica fibre output of 40 microns of core diameters, numerical aperture 0.2.In view of photogene biotic experiment optical fiber core diameter used mostly is 200 μ m and 300 μ m, in the present embodiment, adopt the optical fiber output of 40 μ m can obtain very high coupling fiber rate, improved the accessibility to miscellaneous equipment.If adopt light emitting diode (LED) as excited light source, emission wavelength can be chosen conventional 450-480nm scope blue light according to the sensitive wave length of light sensation gene, 560-590nm scope gold-tinted and 630-670nm scope HONGGUANG etc., optional wavelength is more, substantially whole limit of visible spectrum can be covered, after luminescent device and tail optical fiber one end coupling with the required diameter optical fiber of fibre-optical splice, device can be directly used in.
Light sensation gene stimulating apparatus of the present invention is not limited to adopt the electronic devices and components of above concrete model, can adopt as required other model electronic devices and components with same or similar function, should too not limit the scope of the invention herein.
Light sensation gene stimulating apparatus of the present invention adopts cheap, conventional, general a small amount of electronic devices and components, adopts surface mount mode to make whole device realize miniaturization.Adopt modularized design, can upgrade and rapid-maintenance replacing for requiring, can be for light sensation genetic recipient dissimilar in biological study and therapeutic treatment and effect be stimulated and makes it produce corresponding function.
The present invention also provides a kind of control method of light sensation gene stimulating apparatus, and the method comprises:
Step S1: CPU, wireless radio frequency modules, switch driving circuit, digital regulation resistance, automatic power control circuitry, excited light source and light sensitive diode are powered by power supply and the Voltage stabilizing module that is connected in described power supply;
Step S2: utilize wireless radio frequency modules receive external command and send the instruction of reception to CPU by serial ports;
Step S3: described CPU is opened corresponding I/O mouth according to instruction, and by bus assignment to switch driving circuit or digital regulation resistance;
Step S4: described CPU drives described switch driving circuit by corresponding I/O mouth output low and high level, realizes conducting and the disconnection of excited light source, forms light pulse;
Step S5: described CPU is controlled described digital regulation resistance by corresponding I/O mouth, changes the size of the static working current of light sensitive diode by changing the resistance of described digital regulation resistance, thus the initial power of described excited light source controlled;
Step S6: receive the light of output dorsad of described excited light source and be converted to photoelectric current by light sensitive diode and feed back to automatic power control circuitry, utilize automatic power control circuitry to carry out feedback regulation to realize out light power stabilising output to the luminous power that goes out of described excited light source.
The protection domain that it is pointed out that the control method of light sensation gene stimulating apparatus of the present invention is not limited to the step execution sequence that the present embodiment is enumerated.
Concrete, utilize the Transistor-Transistor Logic level of a part of port generation of described CPU to trigger described switch driving circuit, by software delay, control the time of low and high level, regulate described excited light source output light frequency and dutycycle.
Concrete, can carry out multichannel control by the multichannel interface of CPU, as required the light pulse wavelength of light sensation gene stimulating apparatus output is extended to two or more.Can control the light pulse that different excited light sources produces different wave length by same switch driving circuit; Also can pass through different switch driving circuits, utilize different pulse parameter settings, control the light pulse that different excited light sources produces different frequency or different wave length.
Concrete, the light pulse of exporting respectively or exporting simultaneously different wave length or different frequency by different optical fiber, or the light pulse by an optical fiber output different wave length or different frequency by optical fiber combiner.
Concrete, can pass through the external multiple sensors of multichannel interface of CPU, utilize described CPU pick-up transducers data, and send data to wireless terminal, or according to data content, regulate output light frequency or the wavelength of excited light source.
Concrete, can utilize described wireless radio frequency modules by different light sensation gene stimulating apparatus network consistings, to study the photostimulation characteristic of life colony.
The light pulse that the control method of light sensation gene stimulating apparatus of the present invention is controlled described light sensation gene stimulating apparatus generation to be needed stimulates and makes it produce corresponding function light sensation genetic recipient dissimilar and effect, can meet the demands such as scientific research, disease treatment.
In sum, small-sized remote-controlled light sensation gene stimulating apparatus and control method thereof of the present invention, there is following beneficial effect: (1) small-sized remote-controlled light sensation gene stimulating apparatus of the present invention adopts simple particular electrical circuit topology to realize microminiaturized micro-power consumption requirement, can meet that human body is implanted, the needs of wearable, biological study, Animal Behavior Science research; (2) pulse width covers millisecond to a second scope, and the adjustable needs that stimulate to adapt to light sensation gene cell of dutycycle numeral; (3), by sensor acquisition data and be sent to wireless terminal or regulated the output optical parameter of excited light source by CPU according to data, can be used for studying light sensation stimulates the impact on Animal Behavior Science; (4) physical circuit topology consists of small scale integration, wireless radio frequency modules, excited light source, CPU, automatic power control circuitry and switch driving circuit etc., described small scale integration is connected with power supply by Voltage stabilizing module, and other funtion part in difference connected system, to realize the design to the integration of each funtion part and locus; (5) switch adds the automatic power control circuitry can be so that excited light source is realized stable power stage in wider temperature range; (6) device can adopt packed by metal casing, has guaranteed good heat dissipation characteristics, has effectively extended the service life of excited light source; (7) wireless radio frequency modules can adopt Bluetooth technology, has very strong versatility and compatibility, can be for connecting plurality of devices, and very effectively controlled cost; (8) CPU has multichannel interface, can external multiple sensors, also can carry out multichannel control, and there is very strong extended capability, can realize intelligent monitoring; (9) device of the present invention have low in energy consumption, volume is little, stability is high, control is convenient, wide application, regulate advantage rapidly, be highly suitable for the experiment of light sensation gene, and filled up the blank of Wearable light sensation stimulating apparatus in photogene field, there is boundless market prospect.So the present invention has effectively overcome various shortcoming of the prior art and tool high industrial utilization.
Above-described embodiment is illustrative principle of the present invention and effect thereof only, but not for limiting the present invention.Any person skilled in the art scholar all can, under spirit of the present invention and category, modify or change above-described embodiment.Therefore, such as in affiliated technical field, have and conventionally know that the knowledgeable, not departing from all equivalence modifications that complete under disclosed spirit and technological thought or changing, must be contained by claim of the present invention.
Claims (25)
1. a light sensation gene stimulating apparatus, is characterized in that, described light sensation gene stimulating apparatus comprises:
CPU;
The wireless radio frequency modules, switch driving circuit and the digital regulation resistance that are connected with described CPU; Described wireless radio frequency modules receives external command and sends the instruction of reception to described CPU by serial ports; Described CPU is opened corresponding I/O mouth according to instruction, and gives described switch driving circuit or digital regulation resistance by bus assignment; Described CPU drives described switch driving circuit by corresponding I/O mouth output low and high level, and controls described digital regulation resistance by corresponding I/O mouth, changes the resistance of described digital regulation resistance;
The automatic power control circuitry being connected with described switch driving circuit and described digital regulation resistance, and the excited light source and the light sensitive diode that are connected with described automatic power control circuitry respectively; Described digital regulation resistance changes the static working current of described light sensitive diode by change in resistance, thereby controls the initial power of described excited light source; Described light sensitive diode receives the light of output dorsad of described excited light source and is converted to photoelectric current, feeds back to described automatic power control circuitry; Described automatic power control circuitry carries out feedback regulation to realize out light power stabilising output to the light extraction efficiency of described excited light source;
The power supply being connected with described CPU, wireless radio frequency modules, switch driving circuit, digital regulation resistance, automatic power control circuitry, excited light source and light sensitive diode respectively by Voltage stabilizing module.
2. light sensation gene stimulating apparatus according to claim 1, is characterized in that: described excited light source comprises semiconductor laser, light emitting diode, optical fiber laser or adopts laser diode-pumped solid state laser.
3. light sensation gene stimulating apparatus according to claim 1, is characterized in that: described excited light source is semiconductor laser, and described light sensitive diode is integrated in described semiconductor laser.
4. light sensation gene stimulating apparatus according to claim 1, is characterized in that: the instruction that described wireless radio frequency modules receives comes from remote controller.
5. light sensation gene stimulating apparatus according to claim 1, is characterized in that: described power supply is chargeable lithium cell, and the running voltage of described excited light source is less than 10V.
6. light sensation gene stimulating apparatus according to claim 1, is characterized in that: described CPU is also connected with at least one sensor.
7. light sensation gene stimulating apparatus according to claim 6, is characterized in that: described sensor comprises one or more in velocity sensor, acceleration transducer, displacement transducer, temperature sensor, light sensor, acoustic sensor, gas sensor, flavor sensor.
8. light sensation gene stimulating apparatus according to claim 1, is characterized in that: between a plurality of described light sensation gene stimulating apparatus by described wireless radio frequency modules network consisting.
9. light sensation gene stimulating apparatus according to claim 1, is characterized in that: described wireless radio frequency modules is bluetooth module.
10. light sensation gene stimulating apparatus according to claim 1, is characterized in that: the optical pulse frequency scope being produced by described light sensation gene stimulating apparatus is 0～500Hz, and wave-length coverage is limit of visible spectrum.
11. light sensation gene stimulating apparatus according to claim 1, is characterized in that: described excited light source is connected with silica fibre, the light pulse producing for exporting described excited light source.
12. light sensation gene stimulating apparatus according to claim 1, is characterized in that: described CPU, wireless radio frequency modules, switch driving circuit, digital regulation resistance, automatic power control circuitry, excited light source and light sensitive diode are all integrated on a circuit board.
13. light sensation gene stimulating apparatus according to claim 12, is characterized in that: described CPU, wireless radio frequency modules, switch driving circuit, digital regulation resistance and automatic power control circuitry are integrated on described circuit board by surface mount mode.
14. light sensation gene stimulating apparatus according to claim 1, is characterized in that: the volume of described light sensation gene stimulating apparatus is less than 50cm
3.
15. light sensation gene stimulating apparatus according to claim 1, it is characterized in that: described CPU is connected with at least two switch driving circuits, these at least two switch driving circuits are arranged to respectively different pulse parameters, the light pulse that drives respectively different excited light sources to produce different frequency.
16. light sensation gene stimulating apparatus according to claim 1, it is characterized in that: described CPU is connected with at least two switch driving circuits the light pulse that these at least two switch driving circuits drive respectively different excited light sources to produce different wave length.
17. light sensation gene stimulating apparatus according to claim 1, is characterized in that: described CPU is only connected with a switch driving circuit, the light pulse that this switch driving circuit drives different excited light sources to produce different wave length.
18. according to the light sensation gene stimulating apparatus described in claim 15～17 any one, it is characterized in that: the light pulse of different wave length or different frequency is exported respectively by different optical fiber or output simultaneously, or adopts optical fiber combiner to be exported by an optical fiber.
The control method of 19. 1 kinds of light sensation gene stimulating apparatus, is characterized in that, the method comprises:
By power supply and the Voltage stabilizing module that is connected in described power supply, CPU, wireless radio frequency modules, switch driving circuit, digital regulation resistance, automatic power control circuitry, excited light source and light sensitive diode are powered;
Utilize wireless radio frequency modules receive external command and send the instruction of reception to CPU by serial ports;
Described CPU is opened corresponding I/O mouth according to instruction, and by bus assignment to switch driving circuit or digital regulation resistance;
Described CPU drives described switch driving circuit by corresponding I/O mouth output low and high level, realizes conducting and the disconnection of excited light source, forms light pulse;
Described CPU is controlled described digital regulation resistance by corresponding I/O mouth, changes the size of the static working current of light sensitive diode by changing the resistance of described digital regulation resistance, thereby controls the initial power of described excited light source;
By light sensitive diode, receive the light of output dorsad of described excited light source and be converted to photoelectric current and feed back to automatic power control circuitry, utilize automatic power control circuitry to carry out feedback regulation to realize out light power stabilising output to the luminous power that goes out of described excited light source.
The control method of 20. light sensation gene stimulating apparatus according to claim 19, it is characterized in that: utilize the Transistor-Transistor Logic level of a part of port generation of described CPU to trigger described switch driving circuit, by software delay, control the time of low and high level, regulate described excited light source output light frequency and dutycycle.
The control method of 21. light sensation gene stimulating apparatus according to claim 19, is characterized in that: by same switch driving circuit, control the light pulse that different excited light sources produces different wave length.
The control method of 22. light sensation gene stimulating apparatus according to claim 19, is characterized in that: by different switch driving circuits, control the light pulse that different excited light sources produces different frequency or different wave length.
23. according to the control method of the light sensation gene stimulating apparatus described in claim 21 or 22, it is characterized in that: by different optical fiber, export respectively or export simultaneously the light pulse of different wave length or different frequency, or the light pulse by an optical fiber output different wave length or different frequency by optical fiber combiner.
The control method of 24. light sensation gene stimulating apparatus according to claim 19, it is characterized in that: utilize described CPU pick-up transducers data, and send data to wireless terminal, or according to data content, regulate output light frequency or the wavelength of excited light source.
The control method of 25. light sensation gene stimulating apparatus according to claim 19, is characterized in that: utilize described wireless radio frequency modules by different light sensation gene stimulating apparatus network consistings, to study the photostimulation characteristic of life colony.
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