CN104138437A - Traditional Chinese medicine preparation for treating arrhythmia - Google Patents
Traditional Chinese medicine preparation for treating arrhythmia Download PDFInfo
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- CN104138437A CN104138437A CN201410399221.0A CN201410399221A CN104138437A CN 104138437 A CN104138437 A CN 104138437A CN 201410399221 A CN201410399221 A CN 201410399221A CN 104138437 A CN104138437 A CN 104138437A
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- 239000003814 drug Substances 0.000 title claims abstract description 42
- 238000002360 preparation method Methods 0.000 title claims abstract description 23
- 206010003119 arrhythmia Diseases 0.000 title abstract description 9
- 230000006793 arrhythmia Effects 0.000 title abstract description 9
- 238000011282 treatment Methods 0.000 claims description 23
- 229940079593 drug Drugs 0.000 claims description 12
- 239000000706 filtrate Substances 0.000 claims description 5
- 235000011389 fruit/vegetable juice Nutrition 0.000 claims description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 5
- 239000012467 final product Substances 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 9
- 239000000463 material Substances 0.000 abstract 2
- 241000722870 Dicliptera chinensis Species 0.000 abstract 1
- 241000195954 Lycopodium clavatum Species 0.000 abstract 1
- 240000000249 Morus alba Species 0.000 abstract 1
- 235000008708 Morus alba Nutrition 0.000 abstract 1
- 240000001659 Oldenlandia diffusa Species 0.000 abstract 1
- 244000235659 Rubus idaeus Species 0.000 abstract 1
- 241001146210 Senecio scandens Species 0.000 abstract 1
- 235000021013 raspberries Nutrition 0.000 abstract 1
- 239000009910 sargent gloryvine Substances 0.000 abstract 1
- 231100000331 toxic Toxicity 0.000 abstract 1
- 230000002588 toxic effect Effects 0.000 abstract 1
- 230000033764 rhythmic process Effects 0.000 description 5
- 208000024891 symptom Diseases 0.000 description 5
- 206010008479 Chest Pain Diseases 0.000 description 4
- 206010033557 Palpitations Diseases 0.000 description 4
- 208000001431 Psychomotor Agitation Diseases 0.000 description 4
- 206010038743 Restlessness Diseases 0.000 description 4
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 4
- 206010022437 insomnia Diseases 0.000 description 4
- 206010025482 malaise Diseases 0.000 description 4
- 210000001013 sinoatrial node Anatomy 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- 238000002560 therapeutic procedure Methods 0.000 description 3
- 206010003658 Atrial Fibrillation Diseases 0.000 description 2
- 208000024172 Cardiovascular disease Diseases 0.000 description 2
- 208000000418 Premature Cardiac Complexes Diseases 0.000 description 2
- 206010040741 Sinus bradycardia Diseases 0.000 description 2
- 230000002159 abnormal effect Effects 0.000 description 2
- 230000005856 abnormality Effects 0.000 description 2
- 239000003416 antiarrhythmic agent Substances 0.000 description 2
- 230000000747 cardiac effect Effects 0.000 description 2
- 238000003745 diagnosis Methods 0.000 description 2
- 208000002173 dizziness Diseases 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 231100000957 no side effect Toxicity 0.000 description 2
- 206010047302 ventricular tachycardia Diseases 0.000 description 2
- JWZZKOKVBUJMES-UHFFFAOYSA-N (+-)-Isoprenaline Chemical compound CC(C)NCC(O)C1=CC=C(O)C(O)=C1 JWZZKOKVBUJMES-UHFFFAOYSA-N 0.000 description 1
- 206010002383 Angina Pectoris Diseases 0.000 description 1
- 206010003671 Atrioventricular Block Diseases 0.000 description 1
- 229930003347 Atropine Natural products 0.000 description 1
- 206010049765 Bradyarrhythmia Diseases 0.000 description 1
- 208000010271 Heart Block Diseases 0.000 description 1
- 206010019280 Heart failures Diseases 0.000 description 1
- RKUNBYITZUJHSG-UHFFFAOYSA-N Hyosciamin-hydrochlorid Natural products CN1C(C2)CCC1CC2OC(=O)C(CO)C1=CC=CC=C1 RKUNBYITZUJHSG-UHFFFAOYSA-N 0.000 description 1
- 208000001953 Hypotension Diseases 0.000 description 1
- 206010040639 Sick sinus syndrome Diseases 0.000 description 1
- 208000003734 Supraventricular Tachycardia Diseases 0.000 description 1
- 208000001871 Tachycardia Diseases 0.000 description 1
- 206010047281 Ventricular arrhythmia Diseases 0.000 description 1
- 238000011298 ablation treatment Methods 0.000 description 1
- 230000003288 anthiarrhythmic effect Effects 0.000 description 1
- 230000001746 atrial effect Effects 0.000 description 1
- RKUNBYITZUJHSG-SPUOUPEWSA-N atropine Chemical compound O([C@H]1C[C@H]2CC[C@@H](C1)N2C)C(=O)C(CO)C1=CC=CC=C1 RKUNBYITZUJHSG-SPUOUPEWSA-N 0.000 description 1
- 229960000396 atropine Drugs 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000036770 blood supply Effects 0.000 description 1
- 208000006218 bradycardia Diseases 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000006735 deficit Effects 0.000 description 1
- 230000004438 eyesight Effects 0.000 description 1
- 208000035474 group of disease Diseases 0.000 description 1
- 230000036543 hypotension Effects 0.000 description 1
- 229940039009 isoproterenol Drugs 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000013546 non-drug therapy Methods 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- GOLXNESZZPUPJE-UHFFFAOYSA-N spiromesifen Chemical compound CC1=CC(C)=CC(C)=C1C(C(O1)=O)=C(OC(=O)CC(C)(C)C)C11CCCC1 GOLXNESZZPUPJE-UHFFFAOYSA-N 0.000 description 1
- 230000006794 tachycardia Effects 0.000 description 1
- 208000003663 ventricular fibrillation Diseases 0.000 description 1
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- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a traditional Chinese medicine preparation for treating arrhythmia. The traditional Chinese medicine preparation is prepared from the following traditional Chinese medicinal materials by weight: 40-80g of dicliptera chinensis, 10-20g of sargentgloryvine stems, 3-11g of radix cynanchi atrati, 3-11g of fructus kochiae, 3-11g of mulberry twig, 3-11g of raspberries, 1-5g of lycopodium clavatum, 1-5g of oldenlandia diffusa and 1-5g of senecio scandens. The traditional Chinese medicine preparation has the advantages that the used traditional Chinese medicinal materials are in accord with the regulation of Pharmacopoeia of the People's Republic of China; and the medicine is safe and reliable and is rapid in taking effects, remarkable in curative effect, safe in use and free of toxic or side effect when being used for treating arrhythmia.
Description
Technical field
The present invention relates to technical field of Chinese medicines, specifically refer to that one treats ARR Chinese medicine preparation.
Background technology
Arrhythmia is because sinuatrial node is exciting abnormal or excitement results from beyond sinuatrial node, exciting conduction slowly, retardance or through abnormal passage conduction, the origin of cardiomotility and (or) conductive impairment cause frequency and (or) the allorhythmia of heartbeat.The ecg characteristics of sinus rhythm is: P ripple rule occurs, and P waveform state shows exciting from sinuatrial node (be P ripple upright in I, II, aVF, V4～V6, be inverted at aVR).The frequency of normal sinus rhythm is generally 60 ~ 100 beats/min.During clinically by arrhythmia episode, the speed of heart rate is divided into rapidity and the large class of bradyarrhythmia two, and the former sees premature beat, tachycardia, atrial fibrillation and ventricular fibrillation etc., and adult's heart rate exceedes 100 beats/min for overrunning; The latter is taking sinus bradycardia and various conduction block as common, and heart rate is excessively slow, lower than 60 beats/min, has a strong impact on the blood supply of the main organs such as the heart, brain and occurs the symptom such as giddy, dim eyesight.Arrhythmia is one group of disease important in cardiovascular disease.It can be fallen ill separately and also can occur together with cardiovascular diseases.
ARR making a definite diagnosis will be leaned on electrocardiogram mostly, and some patients were can be made tentative diagnosis according to medical history and sign.Question closely in detail when outbreak heart rate, the rhythm and pace of moving things whether (rule, leak the sense etc. of fighting), outbreak start-stop and persistent period.When outbreak, have or not the performances such as hypotension, faintness or intimate faintness, tic, angina pectoris or heart failure, and inducement, frequency and the treatment process of previously outbreak, contribute to judge arrhythmia.
ARR pathogenic factor is very complicated, also varied to its treatment.For different pathogeny, have at present by the Western medicine such as isoproterenol, atropine and increase autorhythmia of cardiac and (or) accelerate conduction, have by the non-drug therapy such as cardiac pacemaker, electric defibrillation, radio-frequency (RF) ablation treatment.Long-term taking anti-arrhythmic all has side effect in various degree, serious caused ventricular arrhythmia or heart block and fatal.Therefore, when clinical practice, should strictly grasp indication, note untoward reaction, so that emergent at any time.
Summary of the invention
The object of the invention is exactly the defect in order to make up prior art, provide a kind of instant effect, evident in efficacy, make
With safely, the ARR Chinese medicine preparation for the treatment of that has no side effect.The present invention is achieved by the following technical solutions:
One is treated ARR Chinese medicine preparation, is made up of the Chinese crude drug of following weight: Herba Diclipterae Chinensis 40 ~ 80g, Caulis Sargentodoxae 10 ~ 20g, Radix Cynanchi Atrati 3 ~ 11g, the Fructus Kochiae 3 ~ 11g, Ramulus Mori 3 ~ 11g, Fructus Rubi 3 ~ 11g, Herba Lycopodii 1 ~ 5g, Herba Hedyotidis Diffusae 1 ~ 5g, Herba Senecionis Scandentis 1 ~ 5g.
Preferably, one is treated ARR Chinese medicine preparation, is made up of the Chinese crude drug of following weight: Herba Diclipterae Chinensis 60g, Caulis Sargentodoxae 15g, Radix Cynanchi Atrati 7g, Fructus Kochiae 7g, Ramulus Mori 7g, Fructus Rubi 7g, Herba Lycopodii 3g, Herba Hedyotidis Diffusae 3g, Herba Senecionis Scandentis 3g.
The preparation method of the ARR Chinese medicine preparation of above-mentioned treatment is: the Chinese crude drug that takes described weight is put into drug-decocting appliance, adds 3000 milliliters of pure water; Soak at room temperature 1 hour, makes Chinese crude drug fully moistening, fully fried in order to medicine juice; Boil with high heat and use again slow fire instead and decoct 1 hour, remove by filter medicinal residues, filtrate is concentrated into 500 milliliters and get final product.
Therapeutic Method: oral, one time 10 milliliters, sooner or later respectively once, take continuously two months.
The invention has the advantages that used Chinese crude drug meets Pharmacopoeia of People's Republic of China regulation, safety of medicine is reliable, and beneficial effect is compared to existing technology: treat ARR evident in efficacy, instant effect, use safely, have no side effect.
detailed description of the invention:
Below in conjunction with embodiment and case, the present invention is further illustrated.
Embodiment 1:
Take Herba Diclipterae Chinensis 40g, Caulis Sargentodoxae 20g, Radix Cynanchi Atrati 3g, Fructus Kochiae 11g, Ramulus Mori 3g, Fructus Rubi 11g, Herba Lycopodii 1g, Herba Hedyotidis Diffusae 5g, Herba Senecionis Scandentis 1g puts into drug-decocting appliance, adds 3000 milliliters of pure water; Soak at room temperature 1 hour, makes Chinese crude drug fully moistening, fully fried in order to medicine juice; Boil with high heat and use again slow fire instead and decoct 1 hour, remove by filter medicinal residues, filtrate is concentrated into 500 milliliters and obtains the ARR Chinese medicine preparation for the treatment of.
Embodiment 2:
Take Herba Diclipterae Chinensis 80g, Caulis Sargentodoxae 10g, Radix Cynanchi Atrati 11g, Fructus Kochiae 3g, Ramulus Mori 11g, Fructus Rubi 3g, Herba Lycopodii 5g, Herba Hedyotidis Diffusae 1g, Herba Senecionis Scandentis 5g puts into drug-decocting appliance, adds 3000 milliliters of pure water; Soak at room temperature 1 hour, makes Chinese crude drug fully moistening, fully fried in order to medicine juice; Boil with high heat and use again slow fire instead and decoct 1 hour, remove by filter medicinal residues, filtrate is concentrated into 500 milliliters and obtains the ARR Chinese medicine preparation for the treatment of.
Embodiment 3:
Take Herba Diclipterae Chinensis 60g, Caulis Sargentodoxae 15g, Radix Cynanchi Atrati 7g, Fructus Kochiae 7g, Ramulus Mori 7g, Fructus Rubi 7g, Herba Lycopodii 3g, Herba Hedyotidis Diffusae 3g, Herba Senecionis Scandentis 3g puts into drug-decocting appliance, adds 3000 milliliters of pure water; Soak at room temperature 1 hour, makes Chinese crude drug fully moistening, fully fried in order to medicine juice; Boil with high heat and use again slow fire instead and decoct 1 hour, remove by filter medicinal residues, filtrate is concentrated into 500 milliliters and obtains the ARR Chinese medicine preparation for the treatment of.
In order to check Chinese medicine preparation of the present invention to treat ARR effect, choose Bengbu, Anhui Province patients with arrhythmia 66 examples, 27 ~ 73 years old age, 50 years old mean age, wherein male's 39 examples, women's 27 examples.In above 66 routine rhythm abnormality patients; electrocardiogram prompting sinus bradycardia 16 examples; arrhythmia 10 examples; accidental atrial premature beat 5 examples, first degree A-V block 6 examples, sick sinus syndrome 12 examples; rapid atrial fibrillation 5 examples; paroxysmal supraventricular tachycardia 9 examples, sustained ventricular tachycardia 3 examples, patient's ubiquity chest pain, uncomfortable in chest, feel suffocated, the malaise symptoms such as palpitation and restlessness, weak, insomnia and dreamful sleep.All patients are divided into three treatment groups at random, each treatment group 22 examples, wherein, treatment group 1 adopts the Chinese medicine preparation treatment of the embodiment of the present invention 1, the Chinese medicine preparation treatment that treatment group 2 adopts the embodiment of the present invention 2, the Chinese medicine preparation treatment that treatment group 3 adopts the embodiment of the present invention 3.
Therapeutic Method: oral, one time 10 milliliters, sooner or later respectively once, take continuously two months.During treatment, forbid other antiarrhythmic drugs.
Criterion of therapeutical effect:
Effective: ambulatory electrocardiogram recovers normal, chest pain, uncomfortable in chest, feel suffocated, the malaise symptoms such as palpitation and restlessness, weak, insomnia and dreamful sleep disappears or obviously alleviates.
Effective: ambulatory electrocardiogram improvement compared with before treatment, chest pain, uncomfortable in chest, feel suffocated, the malaise symptoms such as palpitation and restlessness, weak, insomnia and dreamful sleep takes a turn for the better.
Invalid: ambulatory electrocardiogram compared with before treatment without any improvement, chest pain, uncomfortable in chest, feel suffocated, the malaise symptoms such as palpitation and restlessness, weak, insomnia and dreamful sleep is without any improvement.
Therapeutic outcome:
| ? | Number | Effective | Effectively | Invalid | Obvious effective rate | Total effective rate |
| Treatment group 1 | 22 | 7 | 15 | 0 | 31.8% | 100% |
| Treatment group 2 | 22 | 11 | 11 | 0 | 50% | 100% |
| Treatment group 3 | 22 | 17 | 5 | 0 | 77.3% | 100% |
In therapeutic process, all patient bodies all do not produce untoward reaction.
Can find out from above-mentioned therapeutic outcome, three prepared Chinese medicine preparation of embodiment of the present invention all have the curative effect of good treatment rhythm abnormality, and total effective rate reaches 100%, wherein, the obvious effective rate of the Chinese medicine preparation of embodiment 3 has reached 77.3%, is the ARR medicine of anti-wide spectrum safely and effectively.This is the beyond thought technique effect that the present invention obtains.
Claims (2)
1. the ARR Chinese medicine preparation for the treatment of, is characterized in that: the Chinese crude drug by following weight is made: Herba Diclipterae Chinensis 40 ~ 80g, Caulis Sargentodoxae 10 ~ 20g, Radix Cynanchi Atrati 3 ~ 11g, the Fructus Kochiae 3 ~ 11g, Ramulus Mori 3 ~ 11g, Fructus Rubi 3 ~ 11g, Herba Lycopodii 1 ~ 5g, Herba Hedyotidis Diffusae 1 ~ 5g, Herba Senecionis Scandentis 1 ~ 5g; Its preparation method is: the Chinese crude drug that takes described weight is put into drug-decocting appliance, adds 3000 milliliters of pure water; Soak at room temperature 1 hour, makes Chinese crude drug fully moistening, fully fried in order to medicine juice; Boil with high heat and use again slow fire instead and decoct 1 hour, remove by filter medicinal residues, filtrate is concentrated into 500 milliliters and get final product.
2. one according to claim 1 is treated ARR Chinese medicine preparation, it is characterized in that: the Chinese crude drug by following weight is made: Herba Diclipterae Chinensis 60g, Caulis Sargentodoxae 15g, Radix Cynanchi Atrati 7g, Fructus Kochiae 7g, Ramulus Mori 7g, Fructus Rubi 7g, Herba Lycopodii 3g, Herba Hedyotidis Diffusae 3g, Herba Senecionis Scandentis 3g.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410399221.0A CN104138437B (en) | 2014-08-14 | 2014-08-14 | One is treated ARR Chinese medicine preparation |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201410399221.0A CN104138437B (en) | 2014-08-14 | 2014-08-14 | One is treated ARR Chinese medicine preparation |
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| CN104138437A true CN104138437A (en) | 2014-11-12 |
| CN104138437B CN104138437B (en) | 2016-05-18 |
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| CN201410399221.0A Active CN104138437B (en) | 2014-08-14 | 2014-08-14 | One is treated ARR Chinese medicine preparation |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101721643A (en) * | 2008-10-27 | 2010-06-09 | 刘波 | Traditional Chinese medicine for treating various heart diseases |
| CN103041239A (en) * | 2012-12-17 | 2013-04-17 | 青岛研博电子有限公司 | Medicine composition |
-
2014
- 2014-08-14 CN CN201410399221.0A patent/CN104138437B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101721643A (en) * | 2008-10-27 | 2010-06-09 | 刘波 | Traditional Chinese medicine for treating various heart diseases |
| CN103041239A (en) * | 2012-12-17 | 2013-04-17 | 青岛研博电子有限公司 | Medicine composition |
Non-Patent Citations (4)
| Title |
|---|
| 吴启富等: "老年病从肾论治举隅", 《第一军医大学学报》 * |
| 吴鸿: "王振涛从"虚""瘀""热"论治快速性心律失常的经验", 《江苏中医药》 * |
| 张国庆: "补肾法为主辨治老年冠心病早搏", 《中国中医急症》 * |
| 梁绍卿: "中药乌头煎剂致严重心律失常一例报告", 《青海医药杂志》 * |
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| CN104138437B (en) | 2016-05-18 |
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Inventor after: Wang Luna Inventor after: Zhang Ling Inventor after: Chen Chongguang Inventor after: Zhao Dunxing Inventor before: Fan Hengyin |
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Effective date of registration: 20160418 Address after: Shushan Daoxiang road Hefei city Anhui province 230088 Peak Road junction and Shu Sheng large pharmacy Applicant after: Zhu Yufang Address before: 230088 room two, unit 22, Shanshui garden, Shushan District, Anhui, Hefei, 1607 Applicant before: Fan Hengyin |
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Effective date of registration: 20180201 Address after: 226000 Guangzhou road Jiangsu city Nantong Province Haimen Economic and Technological Development Zone No. 999 Patentee after: Nantong Construction Engineering Co., Ltd. Address before: Shushan Daoxiang road Hefei city Anhui province 230088 Peak Road junction and Shu Sheng large pharmacy Patentee before: Zhu Yufang |
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