CN103169937B - Drug for treating arrhythmia - Google Patents
Drug for treating arrhythmia Download PDFInfo
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- CN103169937B CN103169937B CN201310127378.3A CN201310127378A CN103169937B CN 103169937 B CN103169937 B CN 103169937B CN 201310127378 A CN201310127378 A CN 201310127378A CN 103169937 B CN103169937 B CN 103169937B
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Abstract
The invention relates to a drug for treating arrhythmia. The drug is prepared from the following substances by weight: radix scrophulariae, rhizoma zingiberis, dogwood, platycodon grandiflorum, coptis chinensis, chrysanthemum, golden-rod, henbane, ephedra, pyrrosia lingua, tabasheer, morinda officinalis, adder-wort, semen sesami nigrum, cocklebur fruit, emblic leafflower fruit, kamuning, kaladana, herba inulae, herb of glabrous sarcandra, clinopodium polycephalum, folium sennae, aleppo avens, uniflower swisscentaury root, rhododendron dauricum, potentilla discolor, calyx seu fructus physalis, root bark of white mulberry, lindley eupatorium, clove, and semen canavaliae. All ingredients of the drug for treating arrhythmia disclosed by the invention are natural materials; and the drug is good in security, accurate in curative effect and suitable for clinical large-scale popularization.
Description
Technical field
The present invention relates to Vasculocardiology Deparment field, relate in particular to a kind of ARR medicament for the treatment of.
Background technology
Arrhythmia refers to that any one such as the rhythm of the heart origin position, cardiac frequency and the rhythm and pace of moving things and conduction of impulse are abnormal.The implication of the word such as " cardiac arrhythmia " or " arrhythmia " biases toward and represents the not normal of the rhythm and pace of moving things, and arrhythmia not only comprises the rhythm and pace of moving things but also comprise the abnormal, more definite and appropriate of frequency.Normal cardiac rhythm originates from sinuatrial node, 60 times～100 times/min of frequency (adult), comparison rule.Sinuatrial node impulsion is through the normal atrioventricular conduction system exciting atrium of order and ventricle, conduction time constant (being grown up 0.12～1.21 second); The conduction time that impulsion arrives ventricular muscles through bundle branch and branch thereof and Purkinje fiber is constant (< 0.10 second) also.
Arrhythmia reason: 1, exciting anomalous origin; 2, exciting conduction abnormalities; 3, exciting anomalous origin and conduction abnormalities exist simultaneously.Be found in various organic heart diseasies, wherein take coronary atherosclerotic heart disease (abbreviation coronary heart disease), cardiomyopathy, myocarditis and rheumatic heart disease (abbreviation rheumatic heart disease) as common, especially when there is heart failure or acute myocardial infarction.Occur in that arrhythmia in basic healthy person or autonomic nervous dysfunction patient is quite a few sees.Other cause of disease still has electrolyte or endocrine disturbance, anesthesia, low temperature, thoracic cavity or operation on heart, drug effect and central nervous system disease etc.Part etiology unknown.
Summary of the invention
The object of this invention is to provide a kind of ARR medicament for the treatment of.
In order to realize object of the present invention, the invention provides a kind of ARR medicament for the treatment of, it is to be made by the material of following weight proportioning: Radix Scrophulariae 5-10 part, Rhizoma Zingiberis 10-20 part, Fructus Corni 20-30 part, Radix Platycodonis 10-20 part, Rhizoma Coptidis 15-25 part, Flos Chrysanthemi 5-15 part, Herba Solidaginis 10-30 part, Semen Hyoscyami 1-15 part, Herba Ephedrae 10-20 part, Folium Pyrrosiae 15-30 part, Concretio Silicea Bambusae 20-30 part, Radix Morindae Officinalis 1-20 part, Rhizoma Bistortae 1-20 part, Semen Sesami Nigrum 10-25 part, Fructus Xanthii 10-30 part, Fructus Phyllanthi 1-20 part, Folium Et Cacumen Murrayae 15-20 part, Semen Pharbitidis 10-20 part, Herba Inulae 15-20 part, Herba Sarcandrae 15-30 part, Herba Clinopodii 10-20 part, Folium Sennae 10-25 part, Radix seu Herba Gei aleppici 5-15 part, Radix Rhapontici 1-20 part, Folium Rhododendri Daurici 15-25 part, Herba Potentillae Discoloris 15-25 part, Calyx Seu Fructus Physalis 10-20 part, Cortex Mori 15-25 part, Herba Eupatorii Lindleyani 20-30 part, Flos Caryophylli 1-20 part and Semen Canavaliae 10-25 part.
Preferably, the ARR medicament for the treatment of of the present invention is to be made by the material of following weight proportioning: 7 parts of Radix Scrophulariaes, 13 parts of Rhizoma Zingiberiss, 22 parts of Fructus Corni, 15 parts of Radix Platycodoniss, 21 parts of Rhizoma Coptidis, 13 parts of Flos Chrysanthemis, 28 parts of Herba Solidaginiss, 11 parts of Semen Hyoscyamis, 17 parts, Herba Ephedrae, 24 parts of Folium Pyrrosiaes, 27 parts of Concretio Silicea Bambusaes, 18 parts of Radix Morindae Officinaliss, 17 parts of Rhizoma Bistortaes, 23 parts of Semen Sesami Nigrums, 21 parts of Fructus Xanthii, 16 parts of Fructus Phyllanthis, 16 parts of Folium Et Cacumen Murrayae, 17 parts of Semen Pharbitidiss, 19 parts of Herba Inulae, 15 parts of Herba Sarcandraes, 14 parts of Herba Clinopodii, 21 parts of Folium Sennae, 11 parts of Radix seu Herba Gei aleppici, 13 parts of Radix Rhapontici, 23 parts of Folium Rhododendri Daurici, 24 parts of Herba Potentillae Discoloris, 14 parts of Calyx Seu Fructus Physaliss, 25 parts of Cortex Mori, 26 parts of Herba Eupatorii Lindleyanis, 24 parts of 16 parts of Flos Caryophyllis and Semen Canavaliaes.
More preferably, described medicament can be tablet, dispersible tablet, capsule or decoction.
Whole compositions of the ARR medicament for the treatment of of the present invention are all natural materials, and safety is better, and curative effect is clear and definite, are suitable for large-scale promotion clinically.
The specific embodiment
Below by embodiment, further illustrate the present invention.It should be understood that embodiments of the invention are for the present invention rather than limitation of the present invention are described.The simple modifications that essence according to the present invention is carried out the present invention all belongs to the scope of protection of present invention.Except as otherwise noted, the percent otherwise in the present invention is percetage by weight.
Embodiment decoction of the present invention
Take 7 grams of Radix Scrophulariaes, 13 grams of Rhizoma Zingiberiss, 22 grams of Fructus Corni, 15 grams of Radix Platycodoniss, 21 grams of Rhizoma Coptidis, 13 grams of Flos Chrysanthemis, 28 grams of Herba Solidaginiss, 11 grams of Semen Hyoscyamis, 17 grams, Herba Ephedrae, 24 grams of Folium Pyrrosiaes, 27 grams of Concretio Silicea Bambusaes, 18 grams of Radix Morindae Officinaliss, 17 grams of Rhizoma Bistortaes, 23 grams of Semen Sesami Nigrums, 21 grams of Fructus Xanthii, 16 grams of Fructus Phyllanthis, 16 grams of Folium Et Cacumen Murrayae, 17 grams of Semen Pharbitidiss, 19 grams of Herba Inulae, 15 grams of Herba Sarcandraes, 14 grams of Herba Clinopodii, 21 grams of Folium Sennae, 11 grams of Radix seu Herba Gei aleppici, 13 grams of Radix Rhapontici, 23 grams of Folium Rhododendri Daurici, 24 grams of Herba Potentillae Discoloris, 14 grams of Calyx Seu Fructus Physaliss, 25 grams of Cortex Mori, 26 grams of Herba Eupatorii Lindleyanis, 24 grams of 16 grams of Flos Caryophyllis and Semen Canavaliaes, add 2000 milliliters, water, in being housed, at 80 ℃, heats 4 hours by the flask of condensing tube, filter.Filtrate is concentrated into 600 milliliters, obtains decoction of the present invention.
Experimental example
With reference to ARR diagnostic criteria (Wu Shaozhen in the diagnosis of < < common disease and efficacy determination (standard) > >, Wu Min. the diagnosis of common disease and efficacy determination (standard) [S] Beijing: China Traditional Chinese Medicine Publishing House, 1999; 58.) formulate the criterion of arrhythmia.
Choose 60 routine patients with arrhythmia, male 30 examples, female's 30 examples; The oldest 82 years old, minimum 37 years old, average (56.6 ± 14.4) year; The course of disease is the longest 12 years, the shortest 6 months, average (3.2 ± 2.7) year.Wherein, atrial fibrillation 30 examples, multiple premature beat 30 examples (morning+chamber, room early, chamber early+knot early), and make a definite diagnosis through Electrocardioscopy.
Use the decoction of preparing in embodiment to treat, every day 3 times, each oral 90 milliliters.Treating 1 month is 1 course for the treatment of.In therapeutic process, carry out cardiac auscultation, electrocardiographic oscillogram and trace electrocardiogram, record arrhythmia conditions, and do 24 hr Ambulatory EKG Monitoring monitorings and blood, urine, stool routine, hepatic and renal function inspection.
Criterion of therapeutical effect
Effective: cardiopalmus, tachypnea, uncomfortable in chest, chest pain disappearance, edema, two lung moist rales disappear, without premature beat, normal ECG; Effective: cardiopalmus, tachypnea, uncomfortable in chest, chest pain alleviate, and two lung moist rales reduce, and premature beat reduces 50%, recovery >=0.05mV before ECG ST section compare Ren institute, T ripple shoals and reaches 50%; Invalid: clinical symptoms, sign and electrocardiogram without obviously changing (the Cortex Phellodendri people. cardiovascular diseases's diagnostic criteria [M]. Beijing: Du is published in learning centre, 1991:33.)
Through the observation of 1 course for the treatment of, find that 60 patient treatment effects are effective, and during whole treatment, do not observe obvious untoward reaction.
After treating 1 course for the treatment of, all patient is followed up a case by regular visits to weekly, continue half a year, find the sign of recurrence.
Claims (2)
1. treat ARR medicament for one kind, it is characterized in that, it is to be made by the material of following weight proportioning: Radix Scrophulariae 5-10 part, Rhizoma Zingiberis 10-20 part, Fructus Corni 20-30 part, Radix Platycodonis 10-20 part, Rhizoma Coptidis 15-25 part, Flos Chrysanthemi 5-15 part, Herba Solidaginis 10-30 part, Semen Hyoscyami 1-15 part, Herba Ephedrae 10-20 part, Folium Pyrrosiae 15-30 part, Concretio Silicea Bambusae 20-30 part, Radix Morindae Officinalis 1-20 part, Rhizoma Bistortae 1-20 part, Semen Sesami Nigrum 10-25 part, Fructus Xanthii 10-30 part, Fructus Phyllanthi 1-20 part, Folium Et Cacumen Murrayae 15-20 part, Semen Pharbitidis 10-20 part, Herba Inulae 15-20 part, Herba Sarcandrae 15-30 part, Herba Clinopodii 10-20 part, Folium Sennae 10-25 part, Radix seu Herba Gei aleppici 5-15 part, Radix Rhapontici 1-20 part, Folium Rhododendri Daurici 15-25 part, Herba Potentillae Discoloris 15-25 part, Calyx Seu Fructus Physalis 10-20 part, Cortex Mori 15-25 part, Herba Eupatorii Lindleyani 20-30 part, Flos Caryophylli 1-20 part and Semen Canavaliae 10-25 part.
2. the ARR medicament for the treatment of according to claim 1, it is characterized in that, it is to be made by the material of following weight proportioning: 7 parts of Radix Scrophulariaes, 13 parts of Rhizoma Zingiberiss, 22 parts of Fructus Corni, 15 parts of Radix Platycodoniss, 21 parts of Rhizoma Coptidis, 13 parts of Flos Chrysanthemis, 28 parts of Herba Solidaginiss, 11 parts of Semen Hyoscyamis, 17 parts, Herba Ephedrae, 24 parts of Folium Pyrrosiaes, 27 parts of Concretio Silicea Bambusaes, 18 parts of Radix Morindae Officinaliss, 17 parts of Rhizoma Bistortaes, 23 parts of Semen Sesami Nigrums, 21 parts of Fructus Xanthii, 16 parts of Fructus Phyllanthis, 16 parts of Folium Et Cacumen Murrayae, 17 parts of Semen Pharbitidiss, 19 parts of Herba Inulae, 15 parts of Herba Sarcandraes, 14 parts of Herba Clinopodii, 21 parts of Folium Sennae, 11 parts of Radix seu Herba Gei aleppici, 13 parts of Radix Rhapontici, 23 parts of Folium Rhododendri Daurici, 24 parts of Herba Potentillae Discoloris, 14 parts of Calyx Seu Fructus Physaliss, 25 parts of Cortex Mori, 26 parts of Herba Eupatorii Lindleyanis, 24 parts of 16 parts of Flos Caryophyllis and Semen Canavaliaes.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310127378.3A CN103169937B (en) | 2013-04-15 | 2013-04-15 | Drug for treating arrhythmia |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201310127378.3A CN103169937B (en) | 2013-04-15 | 2013-04-15 | Drug for treating arrhythmia |
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| CN103169937A CN103169937A (en) | 2013-06-26 |
| CN103169937B true CN103169937B (en) | 2014-09-24 |
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| CN201310127378.3A Expired - Fee Related CN103169937B (en) | 2013-04-15 | 2013-04-15 | Drug for treating arrhythmia |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1102784A (en) * | 1994-02-28 | 1995-05-24 | 虹雨集团公司 | Chinese patent medicine for prevention and control of ischemic cardio-cerebral angiopathy |
| CN101703744B (en) * | 2009-11-18 | 2011-07-06 | 泰一和浦（北京）中医药研究院有限公司 | Chinese medicinal composition for treating palpitation and shortness of breath and preparation method thereof |
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