CN104138422A

CN104138422A - Traditional Chinese medicinal preparation for treating herpes zoster

Info

Publication number: CN104138422A
Application number: CN201310169484.8A
Authority: CN
Inventors: 杨东天
Original assignee: Individual
Current assignee: Individual
Priority date: 2013-05-09
Filing date: 2013-05-09
Publication date: 2014-11-12

Abstract

A traditional Chinese medicinal preparation for treating herpes zoster is prepared through the steps of grinding raw medicines comprising, by weight, 10-50 parts of isatis root, 5-45 parts of scorpion, 10-60 parts of Corydalis tuber, 5-45 parts of borneol, 10-55 parts of Polygonum multiflorum and 20-60 parts of black sesame oil, mixing, examining, disinfecting, and packaging. The traditional Chinese medicinal preparation has heat clearing, detoxifying, vein relaxing, pain relieving, protecting and nerve restoring efficacies for the herpes zoster, is externally applied to kill herpes zoster viruses, can block the copying of herpes zoster virus DNA, and has an obvious pain relieving effect on skins and nerves. The traditional Chinese medicinal preparation can rapidly protect and restore nutrition injured nerves within a short time, and avoids the problem of neuralgia left over curing. The above medicine can instantly relieve pains after external application, has a short treatment course, is changed once every day, and enables the herpes zoster to be cured 3-5d later.

Description

A kind of Chinese medicine preparation for the treatment of herpes zoster

Technical field

The present invention relates to treat the technical field of Chinese medicines of herpes zoster, particularly a kind of Chinese medicine preparation for the treatment of herpes zoster.

Background technology

Herpes zoster is a kind of by chickenpox---varicella zoster virus infects a kind of herpes of trooping to distribute along peripheral nerve causing, the herpes zoster that is referred to as among the people.Primary disease is to move towards skin and the neuralgia viral dermatosis as feature along nerve.Painful area is sent out well at chest, waist, face, also can involve upper limb, perineum and shank, and the feature of pain, taking the lightning sample that automatically occurs, the sample or burn sample pain as main of lancinating, touches and can produce violent pain gently.Can be with serious complication and sequela after morbidity.Complication is mainly viral keratitis and otitis media, and sequela is mainly post herpetic neuralgia and blind.Post herpetic neuralgia mostly is trigeminal neuralgia and the intercostal neuralgia.A lot of patients are still perplexed by diseased region neuralgia after herpes disappears, and what have even exceedes many decades.

Doctor trained in Western medicine is thought both at home and abroad at present, and it is normally extremely difficult that post-herpetic neuralgia patient's pain and paraesthesia are recovered completely.So far, a large amount of various therapies have all been tried out in post-herpetic neuralgia, but still do not find a kind of Therapeutic Method that plays a decisive role, cures for a long time.The treatment of intractable post-herpetic neuralgia is mainly alleviating pain, improves sleep.Improve the quality of living lighter post-herpetic neuralgia is striven promoting it to recover completely.Although many analgesic also have certain curative effect to herpes pain, its toxic and side effects has very large infringement to patient body.

The current domestic traditional Chinese medical science is thought, still, with blood-activating and stasis-removing and cooperation heat-clearing and detoxifying herb, reaches by invigorating QI and blood, strengthens the effect that regulates body's immunity and viral infection resisting.But taking Orally decoctions as main treatment, the course for the treatment of is long, analgesic effect is not obvious, and sequela is difficult to solve.

Summary of the invention

Ordering-the invention is a kind of Chinese medicine preparation for the treatment of herpes zoster of developing on the basis of Chinese medicine and pharmacy.This Chinese medicine preparation has adopted the Chinese medicine of heat-clearing and toxic substances removing, removing obstruction in the collateral to relieve pain, protection and reparation injured nerve, and external application is killed herpesvirus, removed pain, avoids nerve damage.After the drug of topical application, get final product pain relieving, (3-5 days) cured herpes zoster not only in a short time, also protects and repaired injured nerve, thereby avoided neuralgic sequela in treatment.And this medicine only needs external application, just can cure herpes zoster, solve pain, prevent antineuralgic sequela.

(1) the present invention seeks to realize like this:

Treat a Chinese medicine preparation for herpes zoster, it is characterized in that it is the Chinese medicinal ointment made from raw material and the method for following weight proportion:

Radix Isatidis 10-50 part Scorpio 5-45 part Rhizoma Corydalis 10-60 part Borneolum Syntheticum 5-45 part

Radix Polygoni Multiflori 10-55 part Semen Sesami Nigrum oil 20-60 part

(2) preparation method

Take by weight ratio each component raw material, except Semen Sesami Nigrum oil, all the other grind respectively as for subsequent use after fine powder, and Semen Sesami Nigrum oil adds workshop at Oleum sesami and orders (must black Oleum sesami);

B, Radix Isatidis powder, scorpion powder, first English white, Borneolum Syntheticum powder, Radix Polygoni Multiflori powder are added and in Semen Sesami Nigrum oil, be modulated to paste;

C, by after the ointment inspection of making, sterilization subpackage.

Wherein the weight proportion of each raw material is:

10 parts of 10 parts of Borneolum Syntheticums of 10 parts of Rhizoma Corydalis of 25 portions of Scorpios of Radix Isatidis

30 parts of 15 portions of Semen Sesami Nigrum oils of Radix Polygoni Multiflori.

The effect of every Chinese medicine in the present invention:

Radix Isatidis

Effect is: heat-clearing and toxic substances removing, removing heat from blood sore-throat relieving.For purple dark, the mumps of maculae caused by violent heat pathogen, high showing tremendous enthusiasm pain, crimson tongue, sore throat, rotten pharynx scarlet fever, major part pestilence, erysipelas, carbuncle, chickenpox.

Pharmacological action: 1. antivirus action.2. anti-herpes simplex effect.3. immunoregulation effect.

Pharmacological research: think in modern medicine study that Radix Isatidis is to cells of coxsackie B 3 virus ... herpes simplex virus all has inhibitory action.By the anxious nephrocyte of primary breast, viral to infect time, drip medicinal liquid method and test, prove that this product water extraction liquid has anti-1, herpes simplex types 2 virus function, suppresses logarithm and is 2.10.Banlangen Polysaccharide can significantly promote immune function of mice.... promote the growth of mouse thymus and the propagation of thymocyte cell, promote lymphocyte, thymic epithelial cell to secrete thymosin and cytokine, improve the immunity of body.

Radix Isatidis injection intramuscular injection for treating herpes zoster, herpes simplex all have curative effect in various degree clinically.

Scorpio

Effect is: the spasmolytic that relieves dizziness, high fever, infantile convulsions, epilepsy, etc., detoxicating and resolving stagnation of pathogens, removing obstruction in the collateral to relieve pain.The Scorpio processed relieving convulsion power of dispeling the wind is strong ... there is effect of expel wind to dredge collateral pain relieving.

Pharmacological action: analgesic activity.Experimental results show that scorpion venom brings out cortical potential to Encelialgia, skin scorch pain and nervi trigeminus and has stronger inhibitory action.... the analgesia of prompting scorpion venom may act on the maincenter neuron relevant with the pain sensation.Mouse writhing method experiment shows charybdotoxin---the thick poison of analgesic activity of III is strong three times, also strong compared with antondin effect.

Pharmacological research: analgesic activity.Scorpion venom has stronger analgesic activity to Encelialgia, somatalgia, cancerous protuberance pain etc.Multiple acute and chronic pain is all had to stronger inhibitory action.Have effect of good reparation injured nerve, the analgesic activity of scorpion venom active component is better than morphine, again without becoming recessive.

Rhizoma Corydalis

Effect is: the effect that has promoting blood circulation to remove blood stasis, promoting the circulation of QI pain relieving.Application blood-activating and qi-promoting pain relieving, for the heart strand due to coagulation of QI-blood and limbs pain and the each portion of whole body qi depression to blood stasis, pain, dysmenorrhea, lump in the abdomen, postpartum stagnation, traumatic injury, hernia are had a pain.

Pharmacological action: Rhizoma Corydalis has obvious inhibitory action to nervous system, can make of flaccid musclesly, and can separate pain.Oral Rhizoma Corydalis can produce the effect of similar morphine and codeine, can alleviate general neuralgia, headache, lumbago, arthralgia etc.Rhizoma Corydalis is roughly suitable with dolantin to slight spasmic pain effective percentage.

Pharmacological research: clinical confirmation this product analgesic effect is strong compared with Olibanum, Myrrha, Oletum Trogopterori, is the pain relieving good medicine in Chinese medicine.Modern study in Rhizoma Corydalis separable go out 15 kinds of alkaloids, wherein Rhizoma Corydalis first element, second element, ugly element, certain herbaceous plants with big flowers element all have analgesic activity, especially remarkable with the element analgesia of Rhizoma Corydalis second and sedation.

Borneolum Syntheticum

Effect is: logical all keys, loose stagnated fire, the nebula of dispelling improving eyesight, reducing swelling and alleviating pain.

Pharmacological action: 1. the refreshment of having one's ideas straightened out, for apoplexy, expectorant Jue, unconsciousness due to high fever etc.; 2. clearing away heat to alleviate pain, for diseases such as carbuncle, skin ulcer Ulcers, laryngopharynx swelling and pain, aphtha of the mouth and tongue, conjunctival congestion and swelling pain.

Pharmacological research: 1. have report to point out in modern study, Borneolum Syntheticum is applied to local very light to sensorineural stimulation, and has the antisepsis of some pain relieving gentleness, can be used for neuralgia.2. the Main Ingredients and Appearance results of animal in Borneolum Syntheticum is: use the animal model pain threshold of Borneolum Syntheticum group to exceed respectively 2.78 times and 6.24 times than JINGWANHONG group (positive controls) and normal saline group (negative control group).Show that Borneolum Syntheticum has significant analgesic effect.

Radix Polygoni Multiflori

Effect is: protection and reparation are because of the impaired nerve of herpes zoster.

Pharmacological action: have neuroprotective.The rare glycosides of Main Ingredients and Appearance hexichol second in Radix Polygoni Multiflori is to β---and amyloid and hydrogen peroxide cause that Neuronal Survival rate declines and lactic acid dehydrogenase spills to increase and has obvious antagonism.And increase with dosage, its neuroprotective strengthens.... Radix Polygoni Multiflori extract can suppress interleukin and nitric oxide production generation in concentration dependent ground, thereby brings into play neuronic protective effect.

Pharmacological research: modern study discovery, Radix Polygoni Multiflori can promote the growth of neurocyte, and neurasthenia and other nervous system epidemic disease are had to auxiliary therapeutic action.This medicine has powerful antiviral efficacy, has superpower interference effect in viral dna replication process.Copying of blocking virus DNA completely, allows the disintegrate of viral DNA chain, thoroughly blocking virus reproduction process.And can ooze skin absorption, and go deep into subcutaneous through skin basal layer and hypodermal cell layer, clear away virus comprehensively.Medicine can quick and precisely be repaired pathological tissues, effectively strengthens the immunocompetence of skin and human body.Activate peripheral nerve source of supply simultaneously, improve neural deliverability, improve human body microcirculation, recover human body natural's balance, reach the object of the double system of specimen.

Semen Sesami Nigrum oil

Effect is: protection and reparation are because of the impaired nerve of herpes zoster, the neuralgia of avoiding sequela to cause.

Pharmacological action: Semen Sesami Nigrum oil can neutralize all medicines and protection is repaired and nutrition injured nerve.

Pharmacological research: be rich in natural vitamin E in Semen Sesami Nigrum; in every hectogram Semen Sesami Nigrum, reach 50 milligrams; vitamin E is good antioxidant; can protect body cell to avoid the murder by poisoning of free radical by antioxidation; by being penetrated into subcutaneous nerve; can play neuroprotective and be without prejudice, repair damaged nerve, avoid occurring the sequela of postherpetic neuralgia.

Radix Isatidis heat-clearing and toxic substances removing in this medicament, has powerful antivirus action to multiple virus.Radix Polygoni Multiflori enantiopathy toxic action is obvious, thoroughly copying of the DNA of blocking virus.Two medicine cooperative therapy varicella zoster viruss have good curative effect.Scorpio, Rhizoma Corydalis, Borneolum Syntheticum all have good removing obstruction in the collateral to relieve pain effect.Three medicines share the pain that has solved patient.The nerve impaired because of herpes zoster can be protected and repair to Radix Polygoni Multiflori, Semen Sesami Nigrum oil, is neuralgia thereby avoided the sequela after herpes zoster is cured.In addition, Semen Sesami Nigrum oil not only neutralizes all medicines and protection is repaired and nutrition injured nerve, also, due to its oiliness attribute, makes ointment after external application, keeps moist, and sustained drug is played a role.

I try out 35 Patients with Herpes Zosters by above Chinese medicine preparation, and topical agent, after one hour, (does not affect work and sleep) except 2 patients have slight pain, and all the other patients have eliminated pain substantially.Change dressings every day once, within 3-5 days, can cure.After curing, follow up a case by regular visits to, except 7 are not related to, all the other 28 all do not leave neuralgic sequela.

Detailed description of the invention

Embodiment 1

(1) take each component raw material

8 parts of 12 parts of Borneolum Syntheticums of 12 parts of Rhizoma Corydalis of 22 portions of Scorpios of Radix Isatidis

28 parts of 18 portions of Semen Sesami Nigrum oils of Radix Polygoni Multiflori.

Above raw material, except Semen Sesami Nigrum oil, is all ground into respectively fine powder for subsequent use.Semen Sesami Nigrum oil is entrusted Oleum sesami workshop processing (must pure Semen Sesami Nigrum oil).

(2) Radix Isatidis powder, scorpion powder, first English white, Borneolum Syntheticum powder, Radix Polygoni Multiflori powder are added and in Semen Sesami Nigrum oil, be modulated into paste.

(3) ointment of making is tested, subpackage after sterilization.

Embodiment 2

(1) take each component raw material

10 parts of 14 parts of Borneolum Syntheticums of 10 parts of Rhizoma Corydalis of 20 portions of Scorpios of Radix Isatidis

30 parts of 16 portions of Semen Sesami Nigrum oils of Radix Polygoni Multiflori.

(3) ointment of making is tested, subpackage after sterilization.

Embodiment 3

(1) take each component raw material

9 parts of 11 parts of Borneolum Syntheticums of 11 parts of Rhizoma Corydalis of 26 portions of Scorpios of Radix Isatidis

30 parts of 13 portions of Semen Sesami Nigrum oils of Radix Polygoni Multiflori.

(3) ointment of making is tested, subpackage after sterilization.

List of references:

" Chinese medicine complete works-middle powder stick " (the complete works of editorial board of Chinese medicine) (1991, People's Health Publisher)

" encyclopaedia business card " (national scientific and technical terminology validation board)

" the conventional clinical new use of Chinese herbal medicine " (Chen little Gang chief editor) (Guangdong science and technology publishing house publishes 2005)

" there is the magical effect of BAICAO-single medicinal material in family " (Tang Haolong chief editor) (2007, People's Medical Officer Press)

" Chinese medicine processing product clinical practice guide " (Liu Xiaoquan, Shu Jing chief editor) (publication of publishing house of Lanzhou University)

" research of Traditional Chinese Medicine Anti virus antibacterial action " (Ma Zhenya work) (Chinese Medicine science and technology publishing house 2005)

" postherpetic neuralgia evidence-based medicine EBM prevention practice " (chief editor such as Huaxi Hospital Attached to Sichuan Univ Neurology Department Li Qifu) (Chinese Hospitals digital library 2007)

Claims

1. treat a Chinese medicine preparation for herpes zoster, it is characterized in that it is the Chinese medicinal ointment made from raw material and the method for following weight proportion:

Radix Polygoni Multiflori 10-55 part Semen Sesami Nigrum oil 20-60 part.

2. according to a kind of Chinese medicine preparation for the treatment of herpes zoster described in claims 1, wherein the weight ratio of each raw material is:

3. prepare an a kind of process of Chinese medicine preparation for the treatment of herpes zoster as claimed in claim 1, it is characterized in that it is to be prepared from by the following method:

A. take by weight ratio each component raw material, except Semen Sesami Nigrum oil, all the other grind respectively as for subsequent use after fine powder, and Semen Sesami Nigrum oil adds workshop at Oleum sesami and orders (must black Oleum sesami);

B. Radix Isatidis powder, scorpion powder, first English white, Borneolum Syntheticum powder, Radix Polygoni Multiflori powder are added and in Semen Sesami Nigrum oil, be modulated to paste;

C. after the ointment of making being checked, sterilization subpackage.