CN104127809A - Traditional Chinese medicinal composition for treating facial hormone dependence dermatitis - Google Patents
Traditional Chinese medicinal composition for treating facial hormone dependence dermatitis Download PDFInfo
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- CN104127809A CN104127809A CN201410338214.XA CN201410338214A CN104127809A CN 104127809 A CN104127809 A CN 104127809A CN 201410338214 A CN201410338214 A CN 201410338214A CN 104127809 A CN104127809 A CN 104127809A
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Abstract
The invention relates to a traditional Chinese medicinal composition for treating facial hormone dependence dermatitis. The traditional Chinese medicinal composition is prepared by using the following raw materials, by weight, 7 parts of Incised Notopterygium, 7 parts of Cortex Fraxini, 5 parts of Radix Scutellariae, 5 parts of Radix Aconiti Preparata, 3 parts of Semen Brassicae, 3 parts of licorice root and 2-3 parts of Rhizoma curcumae longae. The composition is an external preparation with the advantages of definite therapeutic effect, simple and easy technology and use convenience, developed by using the advantages of traditional Chinese medicines and long term studies accumulated rich experiences. The composition has an anti-inflammatory effect, has a good treatment effect on the facial hormone dependence dermatitis, and has high clinic use safety.
Description
Technical field
The present invention relates to medical technical field, specifically, is the Chinese medicine composition for the treatment of therapy of facial hormone dependent dermatitis about a kind of.
Background technology
Therapy of facial hormone dependent dermatitis (hormone dependence dermatitis, HDD) be clinical common dermatosis, primary disease is the dependence to hormone of former skin lesion causing due to part use Donisolone lack of standardization, and the scytitis infringement that forces patient's life-time service hormone to cause due to this dependency.Skin lesion is taking skin of face attenuation, atrophy, flushing, telangiectasis, acne, the change of rosacea sample etc. as feature, and subjective symptoms is taking scorching hot, pruritus, pain, dry, desquamation and tension as main.The general course of disease of primary disease is longer, Relapse rate is difficult, greatly reduce patient's quality of life, clinical treatment is comparatively thorny, current Therapeutic Method is mainly taking liniment as main, and as tacrolimus ointment, but this medicine belongs to chemical synthetic drug, mechanism of action is unclear and toxic and side effects is larger, and using must be careful.In view of the consideration of safety, preferably adopt tcm methods treatment therapy of facial hormone dependent dermatitis.
Summary of the invention
The object of the invention is for deficiency of the prior art, a kind of Chinese medicine composition for the treatment of therapy of facial hormone dependent dermatitis is provided.
For achieving the above object, the technical scheme that the present invention takes is:
Treat a Chinese medicine composition for therapy of facial hormone dependent dermatitis, described Chinese medicine composition is made up of the crude drug of following weight portion: 7 parts of Rhizoma Et Radix Notopterygiis, 7 parts of Cortex Fraxinis, 5 parts of Radix Scutellariaes, 5 parts of Radix Aconiti Preparatas, 3 parts of Semen Sinapis Albaes, 3 parts, Radix Glycyrrhizae, Rhizoma Curcumae Longae 2-3 part.
Described Chinese medicine composition is made up of the crude drug of following weight portion: 7 parts of Rhizoma Et Radix Notopterygiis, 7 parts of Cortex Fraxinis, 5 parts of Radix Scutellariaes, 5 parts of Radix Aconiti Preparatas, 3 parts of Semen Sinapis Albaes, 3 parts, Radix Glycyrrhizae, 2 parts, Rhizoma Curcumae Longae.
Advantage of the present invention is: utilize the advantage of Chinese medicine and the rich experiences of the accumulation that studies for a long period of time, a kind of determined curative effect of developing, external preparation simple for process, easy to use.The present invention has antiinflammatory action, and by regulation of skin immunologic function, treatment steroid-dependent dermatitis curative effect is good, clinical safe to use.
Detailed description of the invention
Below detailed description of the invention provided by the invention is elaborated.
embodiment 1
chinese medicine composition one
7 parts of Rhizoma Et Radix Notopterygiis, 7 parts of Cortex Fraxinis, 5 parts of Radix Scutellariaes, 5 parts of Radix Aconiti Preparatas, 3 parts of Semen Sinapis Albaes, 3 parts, Radix Glycyrrhizae, 2 parts, Rhizoma Curcumae Longae.
Get above-mentioned seven taste crude drug, add respectively the water extraction three times of 8,6,3 times of amounts, each 3,2,1 hours, merging filtrate, filtrate were concentrated into relative density 1.1, to this concentrated solution centrifuging and taking supernatant, supernatant dilute with water were made to preparation.
embodiment 2
chinese medicine composition two
7 parts of Rhizoma Et Radix Notopterygiis, 7 parts of Cortex Fraxinis, 5 parts of Radix Scutellariaes, 5 parts of Radix Aconiti Preparatas, 3 parts of Semen Sinapis Albaes, 3 parts, Radix Glycyrrhizae, 3 parts, Rhizoma Curcumae Longae.
Get above-mentioned seven taste crude drug, add respectively the water extraction three times of 8,6,3 times of amounts, each 3,2,1 hours, merging filtrate, filtrate were concentrated into relative density 1.1, to this concentrated solution centrifuging and taking supernatant, supernatant dilute with water were made to preparation.
embodiment 3
chinese medicine composition three
7 parts of Rhizoma Et Radix Notopterygiis, 7 parts of Cortex Fraxinis, 5 parts of Radix Scutellariaes, 5 parts of Radix Aconiti Preparatas, 3 parts of Semen Sinapis Albaes, 3 parts, Radix Glycyrrhizae, 2 parts, Rhizoma Curcumae Longae.
Get above-mentioned seven taste crude drug, add respectively the water extraction three times of 8,6,3 times of amounts, each 3,2,1 hours, merging filtrate, filtrate were concentrated into relative density 1.2, to this concentrated solution centrifuging and taking supernatant, supernatant dilute with water were made to preparation.
embodiment 4
chinese medicine composition four
7 parts of Rhizoma Et Radix Notopterygiis, 7 parts of Cortex Fraxinis, 5 parts of Radix Scutellariaes, 5 parts of Radix Aconiti Preparatas, 3 parts of Semen Sinapis Albaes, 3 parts, Radix Glycyrrhizae, 3 parts, Rhizoma Curcumae Longae.
Get above-mentioned seven taste crude drug, add respectively the water extraction three times of 8,6,3 times of amounts, each 3,2,1 hours, merging filtrate, filtrate were concentrated into relative density 1.2, to this concentrated solution centrifuging and taking supernatant, supernatant dilute with water were made to preparation.
embodiment 5
curative effect experiment of the present invention
1 data and method
1.1 clinical data
In August, 2012-2013 meet out-patient's 80 examples of therapy of facial hormone dependent dermatitis diagnostic criteria year October, adopt table of random number method to be divided into treatment group and matched group.Treatment group 42 examples, male's 10 examples, women's 32 examples, 38.6 ± 6.3 years old mean age, average course of disease 36.3 ± 5.7 months; Matched group 38 examples, male's 9 examples, women's 29 examples, 34.3 ± 5.66 years old mean age, average course of disease 33.8 ± 6.2 months, two groups of physical data no difference of science of statistics.In 80 routine patients, protopathy has acne 30 examples, chloasma 19 examples, seborrheic dermatitis 16 examples, eczema 7 examples, contact dermatitis 4 examples, rosacea 4 examples.Two groups of conventional external used medicines of patient have PIYANPING, hydrocortisone butyrate, PIKANG SHUANG, Baolong's health, Eloson, Pevisone etc.
1.2 diagnostic criteria
With reference to pertinent literature: Li Xia. Dermatology Outpatient Department patient uses glucocorticoid external preparation condition survey [J]. Chinese leprosy dermatosis magazine, 2003,8(19): 37, formulate following diagnostic criteria: 1. have more than 1 month external hormone medical history; 2. the 2-10d after hormone that stops using, original disease or Repigmentation or increase the weight of; 3. subjective symptom comprises pruritus, burning sensation, shriveling sense, pain; 4. nbjective symptom comprises inflammatory pimple or abscess, erythema, flushing, edema, xerosis cutis desquamation, corse sweat pore, pigmentation, telangiectasis, atrophy of epidermis.1. patient possess simultaneously, 2. two, and 3., 4. respectively possess a wherein person in bar and can be diagnosed as therapy of facial hormone dependent dermatitis.
1.3 Therapeutic Method
All selected patients all temporarily stop using glucocorticoid ointment, avoid the food such as tobacco and wine, seafood, pungent stimulation, keep happy.Treatment group is for using Chinese medicine composition external application described in embodiment 1 before sleeping every night, evenly affected part of exterior coating, and thickness is no more than 1mm; Matched group uses 0.1% tacrolimus ointment affected part of exterior coating, sooner or later respectively once, suitably reduces access times after remission, and equal outer painting vitamin E ointment in the time not using medicine, treats and carry out therapeutic evaluation after 4 weeks.
1.4 therapeutic evaluation
Sign to two groups of patients (flushing, telangiectasis, pigment change, acne-like rash) is marked respectively, is designated as respectively 0,1,2,3 point of four grade by light and heavy degree and scope, gathers and calculates total mark and therapeutic index.Scoring × 100% before therapeutic index=(scoring after scoring-treatment before treatment)/treatment.Recovery from illness: skin lesion disappears, or only leaves over a little pigmentation, transference cure, therapeutic index declines >=90%; Effective: skin lesion major part disappears, and symptom obviously alleviates, therapeutic index declines >=70%; Effective: skin lesion part disappears, symptom is improved, and therapeutic index declines >=50%; Invalid: skin lesion disappears not obvious, or clinical symptoms is counter sees deterioration, therapeutic index decline < 50%.Recovery from illness, effective, effectively add up to total effective rate.Skin allergy or the gastrointestinal symptom of observing two groups of patients carry out safety evaluatio simultaneously.
1.5 statistical analysis
Data statistic analysis all adopts SPSS 18.0 softwares to complete.Between group, relatively with independent sample t inspection, in group, relatively use paired t-test, enumeration data X 2 test, the rank test of non-normality data acquisition, P<0.05 has statistical significance.
2 results
The comparison of 2.1 liang of group total effectses
The total effects comparative result for the treatment of group and matched group is in table 1.
Table 1 liang group general curative effect comparison
Note: △ represents general curative effect no difference of science of statistics between 0.05, two group of P >.
The comparison of 2.2 liang of group symptom and sign total marks
The symptom and sign total mark comparative result for the treatment of group and matched group is in table 2.
Table 2 liang group symptom and sign total mark comparison (
± S)
Note: * represents that in 0.05, two group of group of P <, relatively treating front and back total mark has significant difference, and after treatment, integration reduces; △ represents to compare no difference of science of statistics between the rear total mark group of 0.05, two group for the treatment of of P >.
2.3 untoward reaction
There is irritation in treatment group 2 examples, the routine patient of matched group 3 local skin in the time of medication 2-4d, shows as causalgia and sensation of pricking increases the weight of, continue medication after symptom alleviate gradually, not stopped treatment.
The above is only the preferred embodiment of the present invention; it should be pointed out that for those skilled in the art, do not departing under the prerequisite of the inventive method; can also make some improvement and supplement, these improvement and the supplementary protection scope of the present invention that also should be considered as.
Claims (2)
1. treat the Chinese medicine composition of therapy of facial hormone dependent dermatitis for one kind, it is characterized in that, described Chinese medicine composition is made up of the crude drug of following weight portion: 7 parts of Rhizoma Et Radix Notopterygiis, 7 parts of Cortex Fraxinis, 5 parts of Radix Scutellariaes, 5 parts of Radix Aconiti Preparatas, 3 parts of Semen Sinapis Albaes, 3 parts, Radix Glycyrrhizae, Rhizoma Curcumae Longae 2-3 part.
2. Chinese medicine composition according to claim 1, is characterized in that, described Chinese medicine composition is made up of the crude drug of following weight portion: 7 parts of Rhizoma Et Radix Notopterygiis, 7 parts of Cortex Fraxinis, 5 parts of Radix Scutellariaes, 5 parts of Radix Aconiti Preparatas, 3 parts of Semen Sinapis Albaes, 3 parts, Radix Glycyrrhizae, 2 parts, Rhizoma Curcumae Longae.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104840561A (en) * | 2015-04-28 | 2015-08-19 | 黄静 | Chinese medicine external lotion for treating facial hormone-dependent dermatitis |
| CN105250635A (en) * | 2015-11-27 | 2016-01-20 | 吴淑芬 | Traditional Chinese medicine composition for treating facial corticosteroid-dependent dermatitis |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102526303A (en) * | 2012-01-10 | 2012-07-04 | 上海市中医医院 | Method for treating hormone dependence dermatitis |
| CN103330801A (en) * | 2013-06-24 | 2013-10-02 | 赵东利 | Traditional Chinese medicinal algae facial mask and preparation method thereof |
| CN103585430A (en) * | 2013-11-25 | 2014-02-19 | 马建国 | Medicinal oil for treating facial hormone-dependent dermatitis and preparation method thereof |
| CN103751338A (en) * | 2014-01-04 | 2014-04-30 | 公翠萍 | Traditional Chinese medicinal composition for treating face hormone-dependent dermatitis |
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2014
- 2014-07-16 CN CN201410338214.XA patent/CN104127809A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102526303A (en) * | 2012-01-10 | 2012-07-04 | 上海市中医医院 | Method for treating hormone dependence dermatitis |
| CN103330801A (en) * | 2013-06-24 | 2013-10-02 | 赵东利 | Traditional Chinese medicinal algae facial mask and preparation method thereof |
| CN103585430A (en) * | 2013-11-25 | 2014-02-19 | 马建国 | Medicinal oil for treating facial hormone-dependent dermatitis and preparation method thereof |
| CN103751338A (en) * | 2014-01-04 | 2014-04-30 | 公翠萍 | Traditional Chinese medicinal composition for treating face hormone-dependent dermatitis |
Non-Patent Citations (1)
| Title |
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| 隋亚楠 等: "润燥止痒胶囊结合中药冷敷治疗面部糖皮质激素依赖性皮炎的临床研究", 《中国医疗前沿》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104840561A (en) * | 2015-04-28 | 2015-08-19 | 黄静 | Chinese medicine external lotion for treating facial hormone-dependent dermatitis |
| CN105250635A (en) * | 2015-11-27 | 2016-01-20 | 吴淑芬 | Traditional Chinese medicine composition for treating facial corticosteroid-dependent dermatitis |
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Application publication date: 20141105 |