CN104127754A - Traditional Chinese medicine composition for treating rheumatism and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating rheumatism and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for treating rheumatism and a preparation method and application thereof. The traditional Chinese medicine composition is prepared from the following raw medicinal materials: speranskia herb, Poria cocos, raw gypsum, Sichuan lovage rhizome, tortoiseshell, scorpion, raw nux vomica, Chinese angelica, long-noded pit viper, stir-fried barley, Chinese caterpillar fungus and honeysuckle flower. The composition is an oral medicinal preparation, has the characteristics of no toxicity, no side effects and convenience in administration, exerts anti-inflammatory and pain-relieving effects, can treat rheumatism, has a substantial effect and a high cure rate and is worth clinical popularization and application.
Description
Technical field
The present invention relates to a kind of rheumatismal Chinese medicine composition and its production and use for the treatment of.
Background technology
Rheumatism is that one group of infringement joint, skeleton, muscle, blood vessel and relevant soft tissue or connective tissue are main disease, and wherein majority is autoimmune disease, and morbidity is many compared with hidden and slow, and the course of disease is longer, and mostly has genetic predisposition.Rheumatism has heterogeneity, it is same disease, have different subtype, due to genetic background, pathogenic factor is different, mechanism is also different, thereby the type of clinical manifestation, symptom, weight and therapeutic response are also not quite similar, mostly rheumatism is to invade the disease of multisystem, the pathology of numerous disease has overlapping more, but rheumatism has arthropathy and symptom mostly, can be up to 70-80%, approximately 50% only has pain, heavy red, swollen, heat, comprehensive inflammation performances such as pain and function are impaired, mostly being multi-joint gets involved, so one of emphasis of current rheumatismal treatment is exactly the treatment to arthritis.
Rheumatic arthritis is a kind of common acute or chronic ICT, can repeatedly show effect and involve heart, clinically take joint and muscle migration is miserable, pain is feature, belong to allergic disease, one of main manifestations of rheumatic fever, mainly with febris acuta and arthralgia onset.From doctor trained in Western medicine angle, doctor trained in Western medicine not yet is finalized the definite cause of disease of primary disease, has autoimmune, and A group beta hemolytic streptococcus infects, viral infection, heredity, the multiple theory such as toxin; From traditional Chinese medical science angle, rheumatic arthritis waits outside invasion and attack human body because wind and cold is damp and hot, impatency meridians, make QI-blood circulation not smooth, cause take muscle joint muscles and bones ache, numb, weighing a kind of disease that joint stuffiness or arthroncus etc. are main clinical manifestation.
The generation of rheumatic arthritis and development are mainly due to due to positive QI-insufficiency and the damp and hot heresy that is affected by the cold, it is a kind of multiple disease, commonly encountered diseases, is also a kind of stubborn disease, especially in high and cold, high Humid Area or the most common in being engaged in the crowd of high and cold, high humidity work.This disease usually delays that difficult more heavy when light during pain, particularly symptom is more obvious during Changes in weather, and even joint deformity, loses viability.
The not specific medicine in current western medical treatment medicine aspect, first-selected NSAID (non-steroidal anti-inflammatory drug), other also have hormone and anti-cell drug toxicity, but Western medicine is only symptomatic treatment, and patient's Long-term taking medicine can cause serious toxic and side effects, as lesions of liver and kidney etc., additionally increased misery to patient.
The traditional Chinese medical science has obtained many achievements to the etiology and pathogenesis research of rheumatic arthritis in recent years, by this rheumatism of Chinese medicine, also accumulated certain experiences, and Chinese medicinal formulae and the Therapeutic Method of some determined curative effects have been founded, treatment by Chinese herbs primary disease have effect significantly, the feature of few side effects, share and can reduce the toxic and side effects that Western medicine brings with Western medicine, reduce relapse rate, increase curative effect.As Chinese patent 200610104413.x, point out that rheumatism not only needs logical also to need " benefits ", because the arthrosis patient course of disease persistent period is all longer, pain is often accompanied by deficiency syndrome for a long time, need " benefit ", if only logical benefit is difficult to reach the arthropathic effect of good treatment; As Chinese patent 201210262080.9, invented a kind ofly with the few treatment rheumatism formula of flavour of a drug number, the party combines anti-inflammatory analgetic effect and calcium supplementing effect;
Summary of the invention
The inventor is that Jintan city, Changzhou has the successor of more than 100 year historical " Han Shi arthrosis tcm therapy ", be engaged in for many years the rheumatismal Chinese medicine preparation development for the treatment of and tcm clinical practice treatment work, on the basis of secret prescription handed down in the family from generation to generation, summing up on the clinical application experiential basis of individual's accumulation for many years, in conjunction with theory of Chinese medical science, read a large amount of Chinese medicines about treating arthropathic books, invented at the specific Chinese medicine composition for the treatment of rheumatism tool.
The inventor gropes to find through the long term test of decades: a certain amount of Herba speranskiae tuberculatae, Poria, Gypsum Fibrosum, Rhizoma Chuanxiong, Carapax et Plastrum Testudinis, Scorpio, Semen Strychni, Radix Angelicae Sinensis, Agkistrodon, Fructus Hordei Vulgaris (parched), Cordyceps, Chinese medicine honeysuckle are used as medicine jointly, treatment rheumatism is had to unique curative effect.For this reason, the inventor has carried out a large amount of tentative tests, guaranteeing under the prerequisite of curative effect, the further perfect different proportionings of each taste Chinese medicine, finally completed test of the present invention, developed and had no side effect voluntarily, the rheumatismal Chinese medicine composition for the treatment of of taking convenience, for the time being called after " effective rheumatism medicine ".Therefore,
One of object of the present invention is to disclose the rheumatismal Chinese medicine composition for the treatment of:
Two of object of the present invention has been to disclose the preparation method for the treatment of rheumatismal Chinese medicine composition.
Three of object of the present invention has been to disclose the application of compositions at preparation treatment medicinal for rheumatism patient object space face.
The detailed technical scheme of the present invention is as follows: the invention discloses a kind of rheumatismal Chinese medicine composition for the treatment of, it is characterized in that, it comprises that described raw medicinal material comprises as the raw medicinal material of the following parts by weight of active ingredient or its activity extract and pharmaceutically useful carrier:
5～30 parts of Herba speranskiae tuberculataes, 5～30 parts, Poria, 5～30 parts of Gypsum Fibrosum, 2～20 parts of Rhizoma Chuanxiongs, 2～20 parts of Carapax et Plastrum Testudiniss, 1～10 part of Scorpio, 1～10 part of Semen Strychni, 2～20 parts of Radix Angelicae Sinensis, 2～20 parts of Agkistrodons, 2～20 parts of Fructus Hordei Vulgaris (parched)s, 1～10 part of Cordyceps, 2～20 parts of Flos Loniceraes.
Preferred " effective rheumatism medicine " raw medicinal material ratio of weight and number of the present invention is:
5～20 parts of Herba speranskiae tuberculataes, 5～20 parts, Poria, 5～20 parts of Gypsum Fibrosum, 2～10 parts of Rhizoma Chuanxiongs, 2～10 parts of Carapax et Plastrum Testudiniss, 1～5 part of Scorpio, 1～5 part of Semen Strychni, 2～10 parts of Radix Angelicae Sinensis, 2～10 parts of Agkistrodons, 2～10 parts of Fructus Hordei Vulgaris (parched)s, 1～5 part of Cordyceps, 2～10 parts of Flos Loniceraes.
The present invention is more preferably " effective rheumatism medicine " raw medicinal material ratio of weight and number:
15 parts of Herba speranskiae tuberculataes, 10 parts, Poria, 10 parts of Gypsum Fibrosum, 6 parts of Rhizoma Chuanxiongs, 6 parts of Carapax et Plastrum Testudiniss, 3 parts of Scorpio, 2 parts of Semen Strychni, 6 parts of Radix Angelicae Sinensis, 5 parts of Agkistrodons, 6 parts of Fructus Hordei Vulgaris (parched)s, 3 parts of Cordycepses, 6 parts of Flos Loniceraes.
In a preferred embodiment of the present invention, by the conventional solvent extraction of described raw medicinal material, make activity extract.Preferred conventional solvent is selected from water, ethanol or their mixture.When the mixture with second alcohol and water is when extracting solvent, the concentration of ethanol is 55～95% (V/V).
Chinese medicine composition of the present invention can be any dosage form of intestinal canal administration, preferably raw medicinal material or its activity extract and any one or more pharmaceutically acceptable carrier is fully mixed and made into oral formulations.Preferred oral formulations is decoction, tablet, powder, granule, drop pill, pill or capsule.
The preparation method that the invention also discloses treatment rheumatismal " effective rheumatism medicine " Chinese medicine composition, comprising:
A, the raw medicinal material of recipe quantity is ground or be ground into fine powder altogether, sieve, fully mix with pharmaceutically acceptable carrier, be prepared into pill, tablet; Or
B, the raw medicinal material of recipe quantity is dropped in extraction pot, add and be selected from water, ethanol or its mixture, as solvent, reflux, and collect filtrate, and 2-3 time so repeatedly, after filtering, concentrates, obtain the pharmaceutically useful decoction of debita spissitudo; Or
C, the raw medicinal material of recipe quantity is dropped in extraction pot, add and be selected from water, ethanol or its mixture are as solvent, reflux, collect filtrate, 2-3 time so repeatedly, after filtering, concentrate and obtain activity extract, after fully being mixed with pharmaceutically acceptable carrier, activity extract makes tablet, pill, granule or capsule.
In a preferred embodiment of the present invention, by the fine powder obtaining in said method a, grind or be ground into impalpable powder, the ratio that is then 1:0.1～0.5 according to impalpable powder with lactose ratio of weight and number is fully mixed them, makes powder.
The effect of each taste Chinese crude drug that the present invention is selected is as follows:
Herba speranskiae tuberculatae (Phryma leptostachya L.) taste sweet, acrid, warm.Enter lung, liver two warps.The analgesia anti rheumatism action of water decoction is similar to Salicylates. and the effect that has expelling wind and removing dampness, relaxing muscles and tendons and activating QI and blood in the collateral, promoting blood circulation and stopping pain for oral administration, water decoction external has antiinflammatory, sterilization, the effect of convergence wound surface, applicable general skin ulcer tinea toxic swelling.
(lndian Buead) is sweet, light for Poria, flat.GUIXIN warp, lung meridian, spleen channel, kidney channel.Cure mainly dysuria; Edema distension; Phlegm retention cough with dyspnea; Vomiting; Insufficiency of the spleen lack of appetite; Have loose bowels; Palpitation and restlessness; Insomnia forgetfulness; Seminal emission nebulousurine.Clinical in dysuria, edema, diarrhea due to hypofunction of the spleen, leukorrhagia, cough due to fluid-retention, phlegm-damp enters network, aching pain in should and back, cardiopalmus, insomnia, anticancer.
Gypsum Fibrosum, pungent, sweet, be slightly cold.Attach to the lung and stomach meridians.Cure mainly apoplexy cold and heat, heart subinverse gas is frightened to be breathed heavily, and xerostomia scorching tongue, can not cease, hardness and fullness in the abdomen pain, evil removing ghost, puerperium incised wound.For oral administration through gastric acid effect, a part becomes soluble calcium salt, the concentration to increasing calcium ion in serum after intestinal absorption enters blood, can suppress thermotaxic centre, alleviate skeletal muscle irritability, reduce vascular permeability, therefore there are the effects such as antipyretic, spasmolytic, antiinflammatory.
Rhizoma Chuanxiong (Rhizoma Ligustici Chuanxiong), acrid in the mouth, warm in nature.Return liver, gallbladder, pericardium channel.There is blood circulation promoting and blood stasis dispelling; Activating QI to alleviate the depression; The effect of wind-expelling pain-stopping.Cure mainly: medicine first choice for the treatment of headache.Menoxenia; Amenorrhea dysmenorrhea; The stagnant raw meat pain of the stasis of blood in puerperal; Lump in the abdomen lump; Pain in chest and hypochondrium; Have a headache dizzy; Anemofrigid-damp arthralgia; Traumatic injury; Ulcer sores.
Carapax et Plastrum Testudinis (Tortoise Shell) salty in the mouth is sweet, flat.YIN nourishing, YANG hyperactivity suppressing, the kidney invigorating, strong bone.Cure mainly and control deficiency of kidney yin, hectic fever due to YIN-deficiency consumptive fever, spits blood, epistaxis, chronic cough, seminal emission, metrorrhagia, leukorrhagia, lumbago, the atrophic debility of bones, stirring of wind due to deficiency of YIN, chronic dysentery, chronic malaria, hemorrhoid, non-closure of fontanels jin infants.
(a scorpion) is pungent for Scorpio, flat; Poisonous.Return Liver Channel.Endogenous wind stopping spasmolytic, dispersing pathogen accumulation, removing obstruction in the collateral to relieve pain.For infantile convulsion, tic spasm, middle air port is askew, hemiplegia, tetanus, rheumatoid arthritis stubborn, migraine and general headache, skin infection, scrofula.
Semen Strychni (Semen Strychni) hardship, cold, poisonous.Return liver, spleen two warps.Excited stomach invigorating, detumescence poison, removing heat from blood.Cure mainly numb limbs and tense tendons, paralysis, inappetence, mass in the abdomen, carbuncle pyogenic infections from tumour or sore, laryngopharynx swelling and pain.Removing obstruction in the collateral to relieve pain, dispersing swelling and dissipating binds, treatment poliomyelitis sequela, prolapse of lumbar intervertebral disc, trigeminal neuralgia, rheumatoid arthritis, traumatic injury, pain due to blood stasis, anemofrigid-damp arthralgia, whole body joint contracture, numbness, cancerous protuberance etc.
Radix Angelicae Sinensis (Radix Angel icae Sinensis) sweet in the mouth; Pungent; Bitter; Warm in nature.Return liver; The heart; Spleen channel.Enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.For blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.
Agkistrodon, sweet, one-tenth, temperature; Poisonous.Return Liver Channel.Dispel the wind, dredging collateral, relieving convulsion.For rheumatoid arthritis stubborn, numbness contracture, middle air port is askew, hemiplegia, tic spasm, tetanus, leprosy scabies, scrofula malignant boil.
Fructus Hordei Vulgaris, taste one-tenth, sweet, warm in nature, cold, nontoxic.Enter spleen, stomach two warps.Stomach function regulating, wide intestinal, diuretic.Control dyspepsia and have loose bowels, urine leaching pain, edema, burn.Can quench the thirst by flat stomach, treatment abdominal distention helps digestion.Main quenching one's thirst except pyretic toxicity, during QI invigorating is adjusted.Nourishing asthenia, makes blood vessels strong, useful to the colour of skin, enriches the five internal organs, digestion paddy food, stopping leak, motionless pathogenic wind.
Cordyceps, the flat sweet in the mouth of property, returns lung, kidney channel.There is the function that tonifying the lung kidney, cough-relieving are coughed, benefit is deficient, support vital essence.Function cures mainly: tonifying deficiency, beneficial vital essence, relieving cough and resolving phlegm.1. antibacterial, 2. immunomodulating, 3. anticancer, 4. antiinflammatory, 5. nourishing kidney, 6. improves adrenal cortex alcohol content, 7. arrhythmia, 8. resisting fatigue, 9. eliminating phlegm and relieving asthma, 10. tranquilizing soporific.
(Flos Lonicerae) is sweet for Flos Lonicerae, micro-hardship, and delicate fragrance, pungent, cold.Return lung, stomach, the heart, large intestine channel.Clinical practice is divided into: [crude drug] be the epidemic febrile disease initial stage 1.: normal with; Fructus Forsythiae, Herba Menthae, tasteless preserved soybean are equal to use, have heat-clearing and toxic substances removing, dispelling wind to relieve the exterior syndrome effect, can be in order to the epidemic febrile disease initial stage, and heating slight chill wind and cold, mouth is micro-thirsty, as Lonicerae and Forsythiae Powder.2. carbuncle furunculosis: normal and Herba Taraxaci, Herba Violae, Flos Chrysanthemi Indici are equal to use, can strengthen antipyretic and antidote functions, can be in order to carbuncle furunculosis, and congestion and swelling pain, as wuwei xiaodu drink; [stir-fry medicine] epidemic febrile disease mid-term: be often equal to use with Radix Scutellariae, Fructus Gardeniae, Gypsum Fibrosum, Caulis Bambusae In Taenia, Rhizoma Phragmitis, have that heat-clearing and toxic substances removing, expelling pathogenic factors from the exterior are gone out, the effect of stomach function regulating preventing or arresting vomiting, can stop up and hinder in order to pathogenic heat, disorder of stomach-QI, fever and irritability, chest and diaphragm painful abdominal mass is vexed, thirsty retch, red tongue tongue is dry, the sliding number of pulse condition.[charcoal drug] be bloody dysentery 1.: normal and Rhizoma Coptidis, Radix Paeoniae Rubra, the Radix Aucklandiae, Herba Portulacae are equal to use, has heat clearing away reason intestinal, changes stagnant and blood effect, can be in order to damp and hot middle resistance, damage intestinal network adipose membrane, and dysentery pus and blood, blood, more than pus, is suffered from abdominal pain, tenesmus.2. fulminant dysentery: be often equal to use with Radix Rehmanniae, Radix Paeoniae Rubra, Cortex Moutan, Rhizoma Coptidis, Cortex Phellodendri, the Radix Pulsatillae, have heat-clearing and toxic substances removing, eliminating pathogenic heat from blood to cure dysentery effect, can attack the intestines and stomach in order to epidemic disease poison, with the QI and blood knot of fighting, light violet pus and blood under dysentery, high fever is thirsty, dysphoria, even unconsciousness and delirium.
Chinese medicine composition of the present invention, can be mixed and made into oral formulations by above-mentioned each medical material and any one or more pharmaceutically acceptable pharmaceutical carrier.For example decoction, tablet, granule, drop pill, pill or capsule etc.
One or more pharmaceutically acceptable pharmaceutical carriers of the present invention comprise: conventional diluent, filler (as lactose, aspartame, xylitol, Polyethylene Glycol), binding agent (starch, microcrystalline Cellulose), disintegrating agent (as the hydroxypropyl cellulose of carboxymethyl cellulose, low replacement), lubricant (as Pulvis Talci, magnesium stearate), wetting agent (as propylene glycol, ethanol), stabilizing agent (EDTA-2Na, sodium thiosulfate, sodium pyrosulfite, sodium sulfite, ethanolamine, sodium bicarbonate, nicotiamide).Can also comprise: magnesium phosphate, magnesium stearate, smoothers sugar, lactose, pectin, propylene glycol, dried starch, Tween-80, dextrin, starch, gelatin, cellulose substances etc.Such as methylcellulose, microcrystalline Cellulose, low melt point paraffin, Polyethylene Glycol, mannitol, cocoa butter or appropriate magnesium stearate etc.
The present invention further discloses " effective rheumatism medicine " at the good effect having aspect the diseases such as treatment rheumatism.Below by inventor animal drug effect data and concrete clinical experiment data, in addition further instruction in decades:
1, animal pharmacodynamics experimental technique:
Medication: by prescription Herba speranskiae tuberculatae 15g, Poria 10g, Gypsum Fibrosum 10g, Rhizoma Chuanxiong 6g, Carapax et Plastrum Testudinis 6g, Scorpio 3g, Semen Strychni 2g, Radix Angelicae Sinensis 6g, Agkistrodon 5g, Fructus Hordei Vulgaris (parched) 6g, Cordyceps 3g, Flos Lonicerae 6g, be ground into fine powder, mix, sieve, then the ratio that is 1:0.1 according to fine powder with lactose ratio of weight and number is fully mixed them, makes powder.Gastric infusion, twice of every day.
Modeling method: last administration is after 1 hour, 3% without calmine from auricular vein injecting anesthetic, bilateral knee periarticular is shaved hair, sterilization skin, light flexed knee, in side position, joint acupuncture needle, with No. 6 entry needles, the uric acid sodium solution 0.3ml (100mg/ml) of prior sterilizing is injected to rabbit right knee joint cavity, cause acute gouty arthritis pathological model.
Positive drug: ibuprofen
Result: in Table 1
Conclusion: with model group comparison: * P<0.05**P<0.001, visible " effective rheumatism medicine " has certain antiinflammatory action, can be used for rheumatismal treatment.
2, clinical experiment method:
By 120 routine rheumatisants, be divided at random observation group's 60 examples, matched group 60 examples, the patient of observation group takes " effective rheumatism medicine " treatment, and matched group adopts conventional western medical treatment.
Result observation group total effective rate reaches 95%, and matched group effective percentage is 75%, and both relatively have marked difference.
Conclusion: take " effective rheumatism medicine " treatment rheumatism, safe and effective, have no side effect, have no adverse reaction, easy to use, cure rate is high, on clinic, promotes the use of.
1) data and method
Physical data: choose rheumatisant's 120 examples in hospital, be divided at random observation group's 60 examples: male 33 examples, female's 27 examples; Age average (46.30 ± 3.3); Matched group 60 examples: male 34 examples, female's 26 examples; Age average (47.20 ± 2.9) year.Two groups of physical data contrasts, difference not statistically significant (P>0.05), has comparability.
Observation group: observation group has a rest, use " effective rheumatism medicine " treatment, square medicine consists of: Herba speranskiae tuberculatae 15g, Poria 10g, Gypsum Fibrosum 10g, Rhizoma Chuanxiong 6g, Carapax et Plastrum Testudinis 6g, Scorpio 3g, Semen Strychni 2g, Radix Angelicae Sinensis 6g, Agkistrodon 5g, Fructus Hordei Vulgaris (parched) 6g, Cordyceps 3g, Flos Lonicerae 6g simultaneously.Water decocting and concentrating obtains decoction, and every day, potion, part took for 3 times.
Matched group: have a rest, give ibuprofen, each 0.5g, every day 3 times.
All take for two groups and treat 1 week as a course for the treatment of.
Curative effect judging standard: with reference to < < new Chinese medicine guideline of clinical investigations > >.Statistical method: adopt χ
2check.
2) result
In Table 2, two groups of contrasts, through X 2 test, χ 2=4.32, P<0.05, difference has statistical significance.
3) discuss
" effective rheumatism medicine " selected medicine has the feature of liver and kidney tonifying, bone and muscle strengthening, expelling wind and cold, numbness relieving and pain relieving, to reach the effect for the treatment of both the principal and secondary aspects of a disease.
Observation group gives " effective rheumatism medicine ", as a result in 60 examples 57 examples effectively, total effective rate reach 95% and cure rate high, therefore think a kind of medicine safely and effectively." effective rheumatism medicine " convenient drug administration, effect is remarkable, and cure rate is high, and clinic is promoted the use of.
3, model case
Model case 1
Lee, man, 14 years old, student, on June 10th, 2010 sees a doctor.
Suffer from child and occur heating, general lassitude sense, has cold like symptoms, sweating cardiopalmus etc., and Qu Mou hospital examines and treat as rheumatism disease, through treatment, takes a turn for the better.But near month, still feel to sleep less not peaceful, the heart is sweating all of a sudden, uncomfortable in chest not smooth, time have palpitation with fear, severe palpitation, thin fur matter is red, small and rapid pulse; This is insufficiency of vital energy and blood, and liquid is kept in not, and this need mark reality, therefore plan effective rheumatism medicine.
Herba speranskiae tuberculatae 15g, Poria 10g, Gypsum Fibrosum 10g, Rhizoma Chuanxiong 6g, Carapax et Plastrum Testudinis 6g, Scorpio 3g, Semen Strychni 2g, Radix Angelicae Sinensis 6g, Agkistrodon 5g, Fructus Hordei Vulgaris (parched) 6g, Cordyceps 3g, Flos Lonicerae 6g, water decocting and concentrating obtains decoction, every day potion, part is taken for 3 times, after taking medicine 1 week, all illness all subtract, former side adds and subtracts, and after January, all illness are all released, livelihood restoration.
Model case 2
Zhang, man, 35 years old, on August 23rd, 2010 saw a doctor
Patient is engaged in the work of fishing for throughout the year, prolapse sense half a year both feet thumb pain, and follow low grade fever from head to foot, and after one week there is swelling in thumb joint part, pain increases the weight of, and is all affected on foot, after medical check, is diagnosed as rheumatoid arthritis.
Herba speranskiae tuberculatae 15g, Poria 10g, Gypsum Fibrosum 10g, Rhizoma Chuanxiong 6g, Carapax et Plastrum Testudinis 6g, Scorpio 3g, Semen Strychni 2g, Radix Angelicae Sinensis 6g, Agkistrodon 5g, Fructus Hordei Vulgaris (parched) 6g, Cordyceps 3g, Flos Lonicerae 6g, be ground into altogether impalpable powder and be prepared into powder, Mel wet suit, every day 3 times, after taking after 3 days, arthroncus disappears, pain alleviates, and continues to take 2 weeks, and thumb pain disappears, freely, half a year is without recurring again so far for joint motion.
The specific embodiment
The following examples can help those skilled in the art more fully to understand the present invention.But do not limit the present invention in any way, the umber in the embodiment of the present invention can be chosen as according to the actual needs gram or kilogram.
Embodiment 1
[prescription] Herba speranskiae tuberculatae 15g, Poria 10g, Gypsum Fibrosum 10g, Rhizoma Chuanxiong 6g, Carapax et Plastrum Testudinis 6g, Scorpio 3g, Semen Strychni 2g, Radix Angelicae Sinensis 6g, Agkistrodon 5g, Fructus Hordei Vulgaris (parched) 6g, Cordyceps 3g, Flos Lonicerae 6g.
[method for making] drops into the medical material of above-mentioned recipe quantity in extraction pot, decocts with water 2 hours, collects filtrate, and 2 times repeatedly, after filtration, mix all filtrate, discard residue, the concentrated decoction of making 2000ml, divides 2-3 times/day and takes.Take continuously 2 days, within the 3rd day, malaise symptoms is eased.
Embodiment 2
[prescription] Herba speranskiae tuberculatae 15g, Poria 10g, Gypsum Fibrosum 10g, Rhizoma Chuanxiong 6g, Carapax et Plastrum Testudinis 6g, Scorpio 3g, Semen Strychni 2g, Radix Angelicae Sinensis 6g, Agkistrodon 5g, Fructus Hordei Vulgaris (parched) 6g, Cordyceps 3g, Flos Lonicerae 6g
[method for making] with 85% (V/V) ethanol extraction 2 times, uses 1500m l by above-mentioned medical material at every turn, extracts 1～2 hour.Obtain extract and then add starch 55g, mix, dry.Separately add starch 85g, xylitol 125g, aspartame 0.6g, mix homogeneously, is ground into fine powder, with 60% ethanol granule processed, dry; Add magnesium stearate appropriate, mix homogeneously, is pressed into 1000, every heavy 1g.
Embodiment 3
[prescription] Herba speranskiae tuberculatae 15g, Poria 10g, Gypsum Fibrosum 10g, Rhizoma Chuanxiong 6g, Carapax et Plastrum Testudinis 6g, Scorpio 3g, Semen Strychni 2g, Radix Angelicae Sinensis 6g, Agkistrodon 5g, Fructus Hordei Vulgaris (parched) 6g, Cordyceps 3g, Flos Lonicerae 6g.
[method for making] above Chinese crude drug, is ground into fine powder, mixes, and sieves, and the ratio that is then 1:0.1 according to fine powder with lactose ratio of weight and number is fully mixed them, makes powder.
Embodiment 4
[prescription] Herba speranskiae tuberculatae 15g, Poria 10g, Gypsum Fibrosum 10g, Rhizoma Chuanxiong 6g, Carapax et Plastrum Testudinis 6g, Scorpio 3g, Semen Strychni 2g, Radix Angelicae Sinensis 6g, Agkistrodon 5g, Fructus Hordei Vulgaris (parched) 6g, Cordyceps 3g, Flos Lonicerae 6g.
[method for making] medicinal material extract: according to the ethanol of 70% weight and aqueous mixtures reflux, extract, 2 times for above-mentioned recipe quantity, each mixture with 2100ml second alcohol and water extracts 1 hour, and filtrate is condensed into extractum, separately adds starch 85g, xylitol 100g, aspartame 0.5g, mix homogeneously, is ground into fine powder, with 60% ethanol granule processed, dry, granulation agent, every bag heavy 3g.
Embodiment 5
Herba speranskiae tuberculatae 15g, Poria 10g, Gypsum Fibrosum 10g, Rhizoma Chuanxiong 6g, Carapax et Plastrum Testudinis 6g, Scorpio 3g, Semen Strychni 2g, Radix Angelicae Sinensis 6g, Agkistrodon 5g, Fructus Hordei Vulgaris (parched) 6g, Cordyceps 3g, Flos Lonicerae 6g, each component is pulverized, the mix homogeneously that sieves, then adds 3.5% Mel to make pill.
Embodiment 6
[prescription] Herba speranskiae tuberculatae 15g, Poria 10g, Gypsum Fibrosum 10g, Rhizoma Chuanxiong 6g, Carapax et Plastrum Testudinis 6g, Scorpio 3g, Semen Strychni 2g, Radix Angelicae Sinensis 6g, Agkistrodon 5g, Fructus Hordei Vulgaris (parched) 6g, Cordyceps 3g, Flos Lonicerae 6g
[method for making] with 85% (V/V) ethanol extraction 2 times, uses 1500m l by above-mentioned medical material at every turn, extracts 1～2 hour.Obtain extract and then add starch 30g, mix, dry.Separately add lactose 50g, mix homogeneously, is ground into fine powder, and with 60% ethanol granule processed, dry, encapsulating capsule, prepares capsule, the heavy 1g of every capsules.
Embodiment 7
[prescription] Herba speranskiae tuberculatae 30g, Poria 5g, Gypsum Fibrosum 5g, Rhizoma Chuanxiong 2g, Carapax et Plastrum Testudinis 20g, Scorpio 1g, Semen Strychni 1g, Radix Angelicae Sinensis 2g, Agkistrodon 2g, Fructus Hordei Vulgaris (parched) 20g, Cordyceps 3g, Flos Lonicerae 20g.
[method for making] above Chinese crude drug, is ground into fine powder, mixes, and sieves, and the ratio that is then 1:0.2 according to fine powder with lactose ratio of weight and number is fully mixed them, makes powder.
Embodiment 8
[prescription] Herba speranskiae tuberculatae 20g, Poria 20g, Gypsum Fibrosum 20g, Rhizoma Chuanxiong 10g, Carapax et Plastrum Testudinis 2g, Scorpio 5g, Semen Strychni 5g, Radix Angelicae Sinensis 2g, Agkistrodon 10g, Fructus Hordei Vulgaris (parched) 2g, Cordyceps 5g, Flos Lonicerae 10g.
[method for making] above Chinese crude drug, is ground into fine powder, mixes, and sieves, and the ratio that is then 1:0.5 according to fine powder with lactose ratio of weight and number is fully mixed them, makes powder.
Embodiment 9
[prescription] Herba speranskiae tuberculatae 10g, Poria 10g, Gypsum Fibrosum 10g, Rhizoma Chuanxiong 5g, Carapax et Plastrum Testudinis 5g, Scorpio 3g, Semen Strychni 3g, Radix Angelicae Sinensis 5g, Agkistrodon 5g, Fructus Hordei Vulgaris (parched) 6g, Cordyceps 3g, Flos Lonicerae 6g.
[method for making] above Chinese crude drug, is ground into fine powder, mixes, and sieves, and the ratio that is then 1:0.3 according to fine powder with lactose ratio of weight and number is fully mixed them, makes powder.
After the preferred embodiment describing in detail, being familiar with this technology personage can be well understood to, can carry out various variations and modification not departing under above-mentioned claim and spirit, any simple modification, equivalent variations and modification that all foundations technical spirit of the present invention is done above embodiment, all belong to the scope of technical solution of the present invention.And the present invention is not also subject to the restriction of example embodiment in description.
Claims (9)
1. treat a rheumatismal Chinese medicine composition, it comprises that described raw medicinal material comprises as the raw medicinal material of the following parts by weight of active ingredient or its activity extract and pharmaceutically useful carrier:
5～30 parts of Herba speranskiae tuberculataes, 5～30 parts, Poria, 5～30 parts of Gypsum Fibrosum, 2～20 parts of Rhizoma Chuanxiongs, 2～20 parts of Carapax et Plastrum Testudiniss, 1～10 part of Scorpio, 1～10 part of Semen Strychni, 2～20 parts of Radix Angelicae Sinensis, 2～20 parts of Agkistrodons, 2～20 parts of Fructus Hordei Vulgaris (parched)s, 1～10 part of Cordyceps, 2～20 parts of Flos Loniceraes.
2. Chinese medicine composition claimed in claim 1, wherein raw medicinal material ratio of weight and number is:
5～20 parts of Herba speranskiae tuberculataes, 5～20 parts, Poria, 5～20 parts of Gypsum Fibrosum, 2～10 parts of Rhizoma Chuanxiongs, 2～10 parts of Carapax et Plastrum Testudiniss, 1～5 part of Scorpio, 1～5 part of Semen Strychni, 2～10 parts of Radix Angelicae Sinensis, 2～10 parts of Agkistrodons, 2～10 parts of Fructus Hordei Vulgaris (parched)s, 1～5 part of Cordyceps, 2～10 parts of Flos Loniceraes.
3. Chinese medicine composition claimed in claim 1, raw medicinal material ratio of weight and number is wherein:
15 parts of Herba speranskiae tuberculataes, 10 parts, Poria, 10 parts of Gypsum Fibrosum, 6 parts of Rhizoma Chuanxiongs, 6 parts of Carapax et Plastrum Testudiniss, 3 parts of Scorpio, 2 parts of Semen Strychni, 6 parts of Radix Angelicae Sinensis, 5 parts of Agkistrodons, 6 parts of Fructus Hordei Vulgaris (parched)s, 3 parts of Cordycepses, 6 parts of Flos Loniceraes.
4. Chinese medicine composition claimed in claim 1, described activity extract is wherein water, ethanol or their mixture are as solvent extraction.
5. the Chinese medicine composition described in claim 1～4 any one, is characterized in that wherein said raw medicinal material or its activity extract and any one or more pharmaceutically acceptable carrier to be mixed and made into oral formulations.
6. Chinese medicine composition claimed in claim 5, oral formulations is wherein decoction, tablet, powder, granule, drop pill, pill or capsule.
7. preparing the method for the treatment of rheumatismal Chinese medicine composition described in claim 1～6 any one is:
A, the raw medicinal material of recipe quantity is ground or be ground into fine powder altogether, sieve, fully mix with pharmaceutically acceptable carrier, be prepared into pill, tablet; Or
B, the raw medicinal material of recipe quantity is dropped in extraction pot, add and be selected from water, ethanol or its mixture, as solvent, reflux, and collect filtrate, and 2-3 time so repeatedly, after filtering, concentrates, obtain the pharmaceutically useful decoction of debita spissitudo; Or
C, the raw medicinal material of recipe quantity is dropped in extraction pot, add and be selected from water, ethanol or its mixture are as solvent, reflux, collect filtrate, 2-3 time so repeatedly, after filtering, concentrate and obtain activity extract, after fully being mixed with pharmaceutically acceptable carrier, activity extract makes tablet, pill, granule or capsule.
8. the method for claim 7, wherein also comprises the fine powder obtaining in method a, grinds or be ground into impalpable powder, and the ratio that is then 1:0.1～0.5 according to impalpable powder with lactose ratio of weight and number is fully mixed them, makes powder.
9. the application of Chinese medicine composition in the rheumatismal medicine of preparation treatment described in claim 1～6 any one.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112043691A (en) * | 2019-06-06 | 2020-12-08 | 常州高新技术产业开发区三维工业技术研究所有限公司 | Pharmaceutical composition and application thereof |
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| CN1868535A (en) * | 2005-05-27 | 2006-11-29 | 王楚清 | Medicine composition for treating rheumatic arthritis and rheumatoid arthritis, and its prepn. method |
| US8003139B2 (en) * | 2002-04-09 | 2011-08-23 | Sichuan Institute Of Chinese Materia Medica | Pharmaceutical composition for treating rheumatism, and method of making same |
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| US8003139B2 (en) * | 2002-04-09 | 2011-08-23 | Sichuan Institute Of Chinese Materia Medica | Pharmaceutical composition for treating rheumatism, and method of making same |
| CN1868535A (en) * | 2005-05-27 | 2006-11-29 | 王楚清 | Medicine composition for treating rheumatic arthritis and rheumatoid arthritis, and its prepn. method |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN112043691A (en) * | 2019-06-06 | 2020-12-08 | 常州高新技术产业开发区三维工业技术研究所有限公司 | Pharmaceutical composition and application thereof |
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