CN104127513A - Medicine for treating localized scleroderma - Google Patents
Medicine for treating localized scleroderma Download PDFInfo
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- CN104127513A CN104127513A CN201410309558.8A CN201410309558A CN104127513A CN 104127513 A CN104127513 A CN 104127513A CN 201410309558 A CN201410309558 A CN 201410309558A CN 104127513 A CN104127513 A CN 104127513A
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Abstract
The invention belongs to the technical field of traditional Chinese medicines, and in order to solve the localized scleroderma treatment problem, the invention provides a medicine for treating localized scleroderma. The medicine is prepared from ramulus cinnamomi, radix paeoniae alba, radix angelicae sinensis, retinervus luffae fructus, flos carthami, trogopterus dung, zaocys, spica prunellae, herba epimedii, herba cistanches, radix dipsaci, herba taxilli, rhizoma drynariae, concha ostreae, radix glycyrrhizae and pheretima according to a certain ratio. The medicine is added with 700 mL of water and the mixture is decocted to 200 mL to form a first dose, and the medicine is added with 500 mL of water and the mixture is decocted to 200 mL to form a second dose. The medicine is taken twice a day on an empty stomach. In the traditional Chinese medicine preparation, radix astragali, radix codonopsis, rhizoma atractylodis macrocephalae and poria are capable of fortifying spleen and replenishing qi; herba epimedii, herba taxilli, rhizoma drynariae, ramulus cinnamomi, radix paeoniae alba, radix angelicae sinensis, zaocys and retinervus luffae fructus are capable of warming the meridian, dissipating cold and freeing the collateral vessels; flos carthami, pheretima, trogopterus dung, spica prunellae and concha ostreae are capable of activating blood and softening hardness; and radix glycyrrhizae is capable of harmonizing all medicinal materials. Compatibility usage and synergistic effect of the above medicinal materials help to realize the treatment purpose. The medicine is good in curative effect, fast in effectiveness, convenient to administrate and free of side effect, and has extremely good treatment effect on localized scleroderma.
Description
technical field:
the present invention relates to a kind of Chinese medicine (belonging to technical field of Chinese medicines), particularly relate to a kind of medicine that is used for the treatment of local scleroderma.
background technology:
local scleroderma is a kind of take skin turgor, sclerosis, narrow connective tissue disease as feature of small blood vessel spasm.Local scleroderma skin lesion is from the beginning of being circle, ovum circular or irregular shape patch, be light red or aubergine, omit tool edema, with the passing of time can expand, become faint yellow or ivory white, tool wax sample gloss, that touches has leather sample hardness, after the several years, gradually leave white or filbert atrophic cicatrix, hair often falls, local hypohidrosis or lossless.Skin lesion can be divided into speckle shape, band shape and drop shape." BI-syndrome related to skin ", " arthralgia due to stagnation of blood ", " BI-syndrome related to skin cellulitis " category of belonging to the traditional Chinese medical science.
treat clinically local scleroderma comparatively thorny, general treatment externally used paste is smeared or Chinese patent medicine, cures the symptoms, not the disease, and does not reach therapeutic purposes.
summary of the invention:
the present invention, in order to solve the problem for the treatment of local scleroderma, provides a kind of medicine that is used for the treatment of local scleroderma.
technical scheme of the present invention is a kind of medicine for the treatment of local scleroderma, is that the Chinese medicine by following weight is that raw material is prepared from proportion:
ramulus Cinnamomi 6-12 part, Radix Paeoniae Alba 6-12 part, Radix Angelicae Sinensis 6-12 part, Retinervus Luffae Fructus 9-15 part, Flos Carthami 3-9 part, Oletum Trogopterori 6-12 part, Zaocys 10-30 part, Spica Prunellae 6-12 part, Herba Epimedii 9-15 part, Herba Taxilli 9-15 part, Rhizoma Drynariae 9-15 part, Concha Ostreae 9-15 part, Radix Glycyrrhizae 3-9 part, Pheretima 9-15 part, Radix Astragali 9-15 part, Radix Codonopsis 9-15 part, Rhizoma Atractylodis Macrocephalae 9-15 part, Poria 9-15 part.
said medicine can be made to the dosage form any for oral administration on pharmaceutics, the preferred dosage form of the present invention is decoction.
the concrete preparation method of medicine of the present invention is first dose of said medicine to be added to 700 milliliters, water decoct to 200 milliliters, and second dose adds 500 milliliters, water and decoct to 200 milliliters.
using method is by the decoction oral of decocting, every day twice, sooner or later empty clothes.
the traditional Chinese medical science is thought: it is Therapeutic Principle that treatment local scleroderma should be take invigorating the spleen and benefiting QI, dispelling cold by warming the meridian dredging collateral, movable blood soft hard.The Radix Astragali, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Poria invigorating the spleen and benefiting QI in side; Herba Epimedii, Herba Taxilli, Rhizoma Drynariae, Ramulus Cinnamomi, the Radix Paeoniae Alba, Radix Angelicae Sinensis, Zaocys, Retinervus Luffae Fructus dispelling cold by warming the meridian dredging collateral; Flos Carthami, Pheretima, Oletum Trogopterori, Spica Prunellae, Concha Ostreae movable blood soft hard; Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription.Said medicine compatibility is used, synergism, thus reach the object for the treatment of.
curative effect of medication of the present invention is good, instant effect, taking convenience, have no side effect, and local scleroderma is had to good therapeutic effect.
for further clinical efficacy and the safety of proof medicine of the present invention.Select 79 routine patients to carry out clinical observation to medicine of the present invention.
example patient in, first quarter moon is a course for the treatment of, one the course for the treatment of cured person 30 examples, two the course for the treatment of cured person 21 examples, two the course for the treatment of above cured person 26 examples, invalid 2 examples.All use the present invention to treat, every day potion, every day twice, sooner or later empty clothes.
criterion of therapeutical effect: effective: skin turgor, sclerosis, small blood vessel spasm transference cure; Effective: skin turgor, sclerosis, small blood vessel spasm symptom are extenuated or disappear; Invalid: treatment front and back are without significant change.
curative effect statistical result after table 1 treatment
?
model case:
embodiment 1.
zhang, women, 48 years old, first visit on June 5 in 2009.Patient is over nearly 2 years, during the ilium portion of left side, have itch, rubescent, but do not arouse attention, the large stretch of lilac red patch of local appearance in March in this year, clear border, dermatoglyph disappears, the summary of touching is hard, and certain hospital examines as " local scleroderma ", gives partial closure's injection, external safflower oil effect is not aobvious, and patient's subjective symptoms is tired, on ordinary days irritability, abdominal distention, wrong after menstruation, amount is few, there is clot, weak.
indagation: the harden plaque that the lamellar atrophy that left side ilium portion is visible 9 centimetres X5 centimetre big or small is hardened, small blood vessel spasm, central part is dispersed in small pieces Dens Elephatis white macula, and surrounding skin is normal, and boundary is clear.Dark tongue quality, tongue is white.
western medicine diagnose: local scleroderma.
tcm diagnosis: BI-syndrome related to skin.
dialectical treatment: invigorating the spleen and benefiting QI, dispelling cold by warming the meridian dredging collateral, movable blood soft hard.
prescription: 12 parts of Ramulus Cinnamomi, 12 parts of the Radix Paeoniae Albas, 9 parts of Radix Angelicae Sinensis, 9 parts of Retinervus Luffae Fructuss, 3 parts, Flos Carthami, 6 parts of Oletum Trogopteroris, 30 parts of Zaocyss, 9 parts of Spica Prunellaes, 12 parts of Herba Epimedii, 12 parts of Herba Taxillis, 12 parts of Rhizoma Drynariae, 15 parts of Concha Ostreaes, 9 parts, Radix Glycyrrhizae, 9 parts of Pheretimas, 15 parts of the Radixs Astragali, 15 parts of Radix Codonopsis, 15 parts of the Rhizoma Atractylodis Macrocephalaes, 12 parts, Poria.
after said medicine (every part in gram) is mixed, decoct into decoction, first dose adds 700 milliliters, water and decocts to 200 milliliters, and second dose adds 500 milliliters, water and decoct to 200 milliliters, every day twice, sooner or later empty clothes.
take 15 doses.
two examine: 15 doses of clothes tops, and skin lesion color turns light, and You Yi center ivory buff is obviously, following the service.
prescription: 9 parts of Ramulus Cinnamomi, 9 parts of the Radix Paeoniae Albas, 12 parts of Radix Angelicae Sinensis, 15 parts of Retinervus Luffae Fructuss, 6 parts, Flos Carthami, 9 parts of Oletum Trogopteroris, 20 parts of Zaocyss, 9 parts of Spica Prunellaes, 15 parts of Herba Epimedii, 15 parts of Herba Taxillis, 15 parts of Rhizoma Drynariae, 12 parts of Concha Ostreaes, 6 parts, Radix Glycyrrhizae, 12 parts of Pheretimas, 12 parts of the Radixs Astragali, 12 parts of Radix Codonopsis, 12 parts of the Rhizoma Atractylodis Macrocephalaes, 15 parts, Poria.
after said medicine (every part in gram) is mixed, decoct into decoction, first dose adds 700 milliliters, water and decocts to 200 milliliters, and second dose adds 500 milliliters, water and decoct to 200 milliliters, every day twice, sooner or later empty clothes.
take 15 doses.
three examine: 15 doses of clothes tops, and the obvious deliquescing of local skin lesion, the light powder of color and luster, epidermis obviously can be mentioned, and disease is obtained effective; Following the service.
prescription: 9 parts of Ramulus Cinnamomi, 9 parts of the Radix Paeoniae Albas, 9 parts of Radix Angelicae Sinensis, 12 parts of Retinervus Luffae Fructuss, 6 parts, Flos Carthami, 9 parts of Oletum Trogopteroris, 20 parts of Zaocyss, 9 parts of Spica Prunellaes, 12 parts of Herba Epimedii, 12 parts of Herba Taxillis, 12 parts of Rhizoma Drynariae, 12 parts of Concha Ostreaes, 6 parts, Radix Glycyrrhizae, 12 parts of Pheretimas, 12 parts of the Radixs Astragali, 12 parts of Radix Codonopsis, 12 parts of the Rhizoma Atractylodis Macrocephalaes, 12 parts, Poria.
after said medicine (every part in gram) is mixed, decoct into decoction, first dose adds 700 milliliters, water and decocts to 200 milliliters, and second dose adds 500 milliliters, water and decoct to 200 milliliters, every day twice, sooner or later empty clothes.
take 15 doses.Local skin lesion deliquescing, the colour of skin is normal, can see dermatoglyph.After half a year, follow up a case by regular visits to not recurrence.
embodiment 2.
blue certain, man 46 years old, first visit on April 28 in 2008.In nearest 3 months, find that there is piece sclerosis of the skin right leg below, color is light red, sometimes slightly itches, and shank has cramp phenomenon sometimes, recently scope increases gradually, Mou hospital examines as " local scleroderma ", through partial closure's treatment, DeGrain, thereby more than relaxation treatment January, the degree of sclerosis of the skin recently increases the weight of to some extent, simultaneously with weak, poor appetite, loose stool, and the poor dreaminess of sleep.
indagation: the skin lesion of visible one 5 centimetres X8 centimetre outside right lower extremity, dorsal portion also has one 3 centimetres of X4 centimetre of big or small skin lesion, and skin lesion hardens, obviously atrophy, dermatoglyph disappears, and color is light red, and there is wax sample gloss on surface, and skin fine hair on birds or animals hair comes off.Body of the tongue is light red, white and thin fur.
western medicine diagnose: local scleroderma.
tcm diagnosis: BI-syndrome related to skin.
dialectical treatment: invigorating the spleen and benefiting QI, dispelling cold by warming the meridian dredging collateral, movable blood soft hard.
prescription: 6 parts of Ramulus Cinnamomi, 6 parts of the Radix Paeoniae Albas, 6 parts of Radix Angelicae Sinensis, 9 parts of Retinervus Luffae Fructuss, 6 parts, Flos Carthami, 9 parts of Oletum Trogopteroris, 10 parts of Zaocyss, 9 parts of Spica Prunellaes, 12 parts of Herba Epimedii, 15 parts of Herba Taxillis, 15 parts of Rhizoma Drynariae, 15 parts of Concha Ostreaes, 9 parts, Radix Glycyrrhizae, 12 parts of Pheretimas, 9 parts of the Radixs Astragali, 9 parts of Radix Codonopsis, 9 parts of the Rhizoma Atractylodis Macrocephalaes, 9 parts, Poria.
after said medicine (every part in gram) is mixed, decoct into decoction, first dose adds 700 milliliters, water and decocts to 200 milliliters, and second dose adds 500 milliliters, water and decoct to 200 milliliters, every day twice, sooner or later empty clothes.
take 15 doses.
two examine: 15 doses of clothes tops, and weak alleviating, sleep improvement but still dreaminess, lower limb knot still time, send out cool, continue to take medicine.
9 parts of Ramulus Cinnamomi, 12 parts of the Radix Paeoniae Albas, 12 parts of Radix Angelicae Sinensis, 15 parts of Retinervus Luffae Fructuss, 9 parts, Flos Carthami, 12 parts of Oletum Trogopteroris, 30 parts of Zaocyss, 6 parts of Spica Prunellaes, 9 parts of Herba Epimedii, 9 parts of Herba Taxillis, 9 parts of Rhizoma Drynariae, 9 parts of Concha Ostreaes, 9 parts, Radix Glycyrrhizae, 9 parts of Pheretimas, 12 parts of the Radixs Astragali, 12 parts of Radix Codonopsis, 15 parts of the Rhizoma Atractylodis Macrocephalaes, 15 parts, Poria.
after said medicine (every part in gram) is mixed, decoct into decoction, first dose adds 700 milliliters, water and decocts to 200 milliliters, and second dose adds 500 milliliters, water and decoct to 200 milliliters, every day twice, sooner or later empty clothes.
take 30 doses.
three examine: 30 doses of clothes tops, and subjective symptoms is clearly better, and sleeps, just adjust, weak disappearance, the obvious deliquescing in lower limb skin lesion place, the slight sweating of lower limb, the colour of skin is substantially to approach normal skin, without other discomforts, above following the service.
prescription: 9 parts of Ramulus Cinnamomi, 9 parts of the Radix Paeoniae Albas, 9 parts of Radix Angelicae Sinensis, 12 parts of Retinervus Luffae Fructuss, 6 parts, Flos Carthami, 9 parts of Oletum Trogopteroris, 20 parts of Zaocyss, 9 parts of Spica Prunellaes, 12 parts of Herba Epimedii, 12 parts of Herba Taxillis, 12 parts of Rhizoma Drynariae, 12 parts of Concha Ostreaes, 6 parts, Radix Glycyrrhizae, 12 parts of Pheretimas, 12 parts of the Radixs Astragali, 12 parts of Radix Codonopsis, 12 parts of the Rhizoma Atractylodis Macrocephalaes, 12 parts, Poria.
after said medicine (every part in gram) is mixed, decoct into decoction, first dose adds 700 milliliters, water and decocts to 200 milliliters, and second dose adds 500 milliliters, water and decoct to 200 milliliters, every day twice, sooner or later empty clothes.
take 15 doses.
the four diagnostic methods: 15 doses of clothes tops, full recovery is normal for skin lesion outside the rigid skin lesion in instep, lower limb.After 1 year, follow up a case by regular visits to not recurrence.
embodiment 3.
zhao, female, 31 years old, first visit on April 18 in 2002.Patient is engaged in Aquatic product business, and both hands contact cold water often, and both hands swelling of every dusk is recently obvious, and tip Raynaud phenomenon is remarkable, and it is rubescent that left hand little finger of toe and the third finger are stretched side sheet, slightly swelling.Center skin lesion color is light, has light, has pain during joint, and at local hospital, by " rheumatoid " treatment, effect is not aobvious.Patient is simultaneously with weak, and two lower limb are heavy, loose stool, and three row on the one, postponed menstruation, hypomenorrhea, the white clear rare amount of leucorrhea color is many on ordinary days.
indagation: extremity tip is not warm, and both hands are purplish red, the left hand little finger of toe agent third finger is stretched very hard that side touches, and skin is difficult to mention, swelling and light.Nonelastic.Red tip of the tongue, tongue is white.
western medicine diagnose: local scleroderma.
tcm diagnosis: BI-syndrome related to skin.
dialectical treatment: invigorating the spleen and benefiting QI, dispelling cold by warming the meridian dredging collateral, movable blood soft hard.
prescription: 12 parts of Ramulus Cinnamomi, 12 parts of the Radix Paeoniae Albas, 12 parts of Radix Angelicae Sinensis, 15 parts of Retinervus Luffae Fructuss, 9 parts, Flos Carthami, 12 parts of Oletum Trogopteroris, 30 parts of Zaocyss, 12 parts of Spica Prunellaes, 15 parts of Herba Epimedii, 15 parts of Herba Taxillis, 15 parts of Rhizoma Drynariae, 15 parts of Concha Ostreaes, 9 parts, Radix Glycyrrhizae, 15 parts of Pheretimas, 15 parts of the Radixs Astragali, 15 parts of Radix Codonopsis, 15 parts of the Rhizoma Atractylodis Macrocephalaes, 15 parts, Poria.
after said medicine (every part in gram) is mixed, decoct into decoction, first dose adds 700 milliliters, water and decocts to 200 milliliters, and second dose adds 500 milliliters, water and decoct to 200 milliliters, every day twice, sooner or later empty clothes.
take 15 doses.
two examine: 15 doses of clothes tops, and stool makes moderate progress, and two row on the one are shaped substantially, and it is warm that hand temperature gradually turns, following the service the place ahead.
prescription: 9 parts of Ramulus Cinnamomi, 9 parts of the Radix Paeoniae Albas, 9 parts of Radix Angelicae Sinensis, 12 parts of Retinervus Luffae Fructuss, 6 parts, Flos Carthami, 9 parts of Oletum Trogopteroris, 20 parts of Zaocyss, 9 parts of Spica Prunellaes, 12 parts of Herba Epimedii, 12 parts of Herba Taxillis, 12 parts of Rhizoma Drynariae, 12 parts of Concha Ostreaes, 6 parts, Radix Glycyrrhizae, 12 parts of Pheretimas, 12 parts of the Radixs Astragali, 12 parts of Radix Codonopsis, 12 parts of the Rhizoma Atractylodis Macrocephalaes, 12 parts, Poria.
after said medicine (every part in gram) is mixed, decoct into decoction, first dose adds 700 milliliters, water and decocts to 200 milliliters, and second dose adds 500 milliliters, water and decoct to 200 milliliters, every day twice, sooner or later empty clothes.
take 15 doses.
three examine: 15 doses of clothes tops, and subjective symptoms is clearly better, and does not ache in joint, and leucorrhea reduces, weak disappearance, the deliquescing of the back of the hand portion skin lesion, can pinch, and continues to take medicine.
prescription: 6 parts of Ramulus Cinnamomi, 6 parts of the Radix Paeoniae Albas, 6 parts of Radix Angelicae Sinensis, 9 parts of Retinervus Luffae Fructuss, 3 parts, Flos Carthami, 6 parts of Oletum Trogopteroris, 10 parts of Zaocyss, 6 parts of Spica Prunellaes, 9 parts of Herba Epimedii, 9 parts of Herba Taxillis, 9 parts of Rhizoma Drynariae, 9 parts of Concha Ostreaes, 3 parts, Radix Glycyrrhizae, 9 parts of Pheretimas, 9 parts of the Radixs Astragali, 9 parts of Radix Codonopsis, 9 parts of the Rhizoma Atractylodis Macrocephalaes, 9 parts, Poria.
after said medicine (every part in gram) is mixed, decoct into decoction, first dose adds 700 milliliters, water and decocts to 200 milliliters, and second dose adds 500 milliliters, water and decoct to 200 milliliters, every day twice, sooner or later empty clothes.
take 20 doses.
the four diagnostic methods: 20 doses of clothes tops, recover normal, disease Defendant heals.
the specific embodiment:
ramulus Cinnamomi 6-12 part, Radix Paeoniae Alba 6-12 part, Radix Angelicae Sinensis 6-12 part, Retinervus Luffae Fructus 9-15 part, Flos Carthami 3-9 part, Oletum Trogopterori 6-12 part, Zaocys 10-30 part, Spica Prunellae 6-12 part, Herba Epimedii 9-15 part, Herba Taxilli 9-15 part, Rhizoma Drynariae 9-15 part, Concha Ostreae 9-15 part, Radix Glycyrrhizae 3-9 part, Pheretima 9-15 part, Radix Astragali 9-15 part, Radix Codonopsis 9-15 part, Rhizoma Atractylodis Macrocephalae 9-15 part, Poria 9-15 part.
after will said medicine mixing, decoct into decoction, first dose adds 700 milliliters, water and decocts to 200 milliliters, and second dose adds 500 milliliters, water and decoct to 200 milliliters, every day twice, sooner or later empty clothes.
Claims (3)
1. a medicine that is used for the treatment of local scleroderma, is characterized in that: the raw material by following weight portion is made:
Ramulus Cinnamomi 6-12 part, Radix Paeoniae Alba 6-12 part, Radix Angelicae Sinensis 6-12 part, Retinervus Luffae Fructus 9-15 part, Flos Carthami 3-9 part, Oletum Trogopterori 6-12 part, Zaocys 10-30 part, Spica Prunellae 6-12 part, Herba Epimedii 9-15 part, Herba Taxilli 9-15 part, Rhizoma Drynariae 9-15 part, Concha Ostreae 9-15 part, Radix Glycyrrhizae 3-9 part, Pheretima 9-15 part, Radix Astragali 9-15 part, Radix Codonopsis 9-15 part, Rhizoma Atractylodis Macrocephalae 9-15 part, Poria 9-15 part.
2. a kind of medicine that is used for the treatment of local scleroderma according to claim 1, is characterized in that: the raw material by following weight portion is made:
9 parts of Ramulus Cinnamomi, 9 parts of the Radix Paeoniae Albas, 9 parts of Radix Angelicae Sinensis, 12 parts of Retinervus Luffae Fructuss, 6 parts, Flos Carthami, 9 parts of Oletum Trogopteroris, 20 parts of Zaocyss, 9 parts of Spica Prunellaes, 12 parts of Herba Epimedii, 12 parts of Herba Taxillis, 12 parts of Rhizoma Drynariae, 12 parts of Concha Ostreaes, 6 parts, Radix Glycyrrhizae, 12 parts of Pheretimas, 12 parts of the Radixs Astragali, 12 parts of Radix Codonopsis, 12 parts of the Rhizoma Atractylodis Macrocephalaes, 12 parts, Poria.
3. a kind of medicine that is used for the treatment of local scleroderma according to claim 2, is characterized in that after described medicament mixed, decocting into decoction oral.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104398997A (en) * | 2014-12-10 | 2015-03-11 | 马立平 | Traditional Chinese medicinal composition for localized scleroderma and preparation method for traditional Chinese medicinal composition |
| CN106362122A (en) * | 2016-10-27 | 2017-02-01 | 谭奇纹 | Traditional Chinese medicine for treating localized scleroderma |
-
2014
- 2014-07-02 CN CN201410309558.8A patent/CN104127513A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104398997A (en) * | 2014-12-10 | 2015-03-11 | 马立平 | Traditional Chinese medicinal composition for localized scleroderma and preparation method for traditional Chinese medicinal composition |
| CN104398997B (en) * | 2014-12-10 | 2017-07-14 | 马立平 | It is a kind of for Chinese medicine composition of scleroderma circumscriptum and preparation method thereof |
| CN106362122A (en) * | 2016-10-27 | 2017-02-01 | 谭奇纹 | Traditional Chinese medicine for treating localized scleroderma |
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Application publication date: 20141105 |