CN104127506A - Producing and processing method with capability of improving quality of desertliving cistanche decoction piece - Google Patents
Producing and processing method with capability of improving quality of desertliving cistanche decoction piece Download PDFInfo
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- CN104127506A CN104127506A CN201410392733.4A CN201410392733A CN104127506A CN 104127506 A CN104127506 A CN 104127506A CN 201410392733 A CN201410392733 A CN 201410392733A CN 104127506 A CN104127506 A CN 104127506A
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- herba cistanches
- desertliving cistanche
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Abstract
The invention discloses a processing method with the capability of improving the quality of a desertliving cistanche decoction piece. The processing method comprises the steps of picking fresh desertliving cistanche, longitudinally cutting into 2-4 parts, standing for 4-6 days under the temperature of 18-25 DEG C, then cutting into thick pieces with the thickness of 5mm, steaming by water for 10 min, and then drying at the temperature of 60-80 DEG C to obtain the desertliving cistanche decoction piece. With the adoption of the processing method, the contents of effective components in the desertliving cistanche decoction piece can be effectively increased, and the quality of the decoction piece is improved.
Description
Technical field
The present invention relates to a kind of habitat processing method of desertliving cistanche sheet, the method can improve the active constituent content in desertliving cistanche sheet effectively, improves prepared slice quality, belongs to the field of Chinese medicines.
Background technology
Version < < Chinese Pharmacopoeia > > regulation in 2010, Herba Cistanches is the fleshy stem of the dry zone scale leaf of orobanchaceae plant cistanche Cistanche deserticola Y.C.Ma or Cistanche Tubulosa Cistanche tubulosa (Schrenk) Wight.Cistanche Hoffmgg. et Link plants mainly contains four kinds of Herba Cistanches (host is Haloxylon sacsaoul or haloxylon persicum Haloxlon a m modendron (C.C.May) Bge), Cistanche Tubulosa (host is Tamarix tamarixspp. red building), Saline Cistanche Herb (host is Herba suadeae glaucae etc.), Herba Cistanches sinensis (host is red sand etc.) etc. in China.Main product, in Xinjiang, the Inner Mongol, Gansu and Yi Dai desert, Ningxia or the salt-soda soil of China, has fabulous medical value, have the title of " desert Radix Ginseng ", is excellent tonic product among the people from ancient times.Modern study shows; in Herba Cistanches, mainly contain the chemical compositions such as phenethyl alcohol glycoside, iridoid glycoside, lignanoid and sterol; the phenethyl alcohol glycoside that echinacoside, cistanoside A, verbascoside and 2 '-acetyl group verbascoside etc. are representative of wherein take is the maximum compounds of Herba Cistanches research report, and oneself confirms that it is the bioactive main matter bases such as Herba Cistanches performance defying age, resisting fatigue, reinforcing the kidney and supporting YANG, raising learning and memory, anti-alzheimer disease pharmacological research.
Chinese Pharmacopoeia has been recorded the processing in production place mode of desertliving cistanche sheet, when spring, Seedling was just unearthed or excavate before frozen soil autumn, removes stem apex that is:, and cutting, dries.Among the people is also fresh herba cistanches is cut to stem apex or soak and scald (it is stopped growing) after stem apex with hot water, be placed under sunlight and dry, or shady and cool place dries in the shade, or dry after salting, or dry after stripping and slicing, section etc.Because fresh herba cistanches fleshy stem moisture conventionally surpasses 80%, so traditional drying mode is very slow, short two weeks, long one to two moon.Have research to point out, in Herba Cistanches, containing a large amount of K, Na, Ca, Fe etc. has the metal ion of activation, wherein K to enzyme catalysis vigor
+concentration is up to 0.3%～2.3%, Na
+concentration is up to 0.1%～1.7%, Ca
2+concentration is up to 0.03%～0.36%, Fe
3+concentration is up to 0.005%～0.14%, particularly in fresh herba cistanches fleshy stem, there is the enzyme systems such as abundant hydrolytic enzyme, glycoside hydrolase and polyphenol oxidase, dried process is because undried Herba Cistanches is for a long time in the bad dried environment such as moistening, damp and hot, and in the course of processing because of reasons such as physical damnifications, the enzyme being activated causes rapidly active enzymic catalytic reaction and produces enzymatic browning, the phenethyl alcohol glycoside compounds isoreactivity composition that causes Herba Cistanches to be rich in, is hydrolyzed, degrades, transforms at enzyme-catalyzed reaction or synthetic new product.Research is also with testing result explanation, in just unearthed fresh herba cistanches fleshy stem, echinacoside and mullein glucoside monomeric compound content can be up to 24.3% (in dries), but different processing mode and from the place of production, kind, in the desertliving cistanche sheet sample that the difference of host and collection season was collected, echinacoside and mullein glucoside monomeric compound content are only 0.03%～1.0%, the active component phenethyl alcohol glycoside compounds that Herba Cistanches is rich in conventional processes is by severely degrade, wherein representative active component echinacoside and mullein glucoside monomeric compound attenuation rate are up to 92.31%～99.87%.Research points out, bad processing technique and drying method are primase catalytic reaction the key factor that causes the active component phenethyl alcohol glycosides degradation loss that Herba Cistanches is rich in.
Based on above-mentioned research conclusion, constantly there is scholar to propose,
after excavating fresh herba cistanches, should kill in time enzyme place reason, and then carry out cutting place, the technique such as being dried of later stage.Such as:
● < < different processing methods affects > > (Yang Jianhua etc. to desertliving cistanche sheet phenylethanoid glycoside, Chinese crude drug, the 33rd the 5th phase of volume of May in 2010,691-693 page) in, explicitly point out: the processing mode of fresh herba cistanches is larger on ingredient content of phenylethanoid glycosides impact in Herba Cistanches sample,, the decoction pieces course of processing should be noted
fastprocess, and implement to press down enzyme measure, to improve the content of phenylethanoid glycoside.
● in the summary of the invention of CN1823914A " processing technology of cistanche decocting pieces ", emphasize: section be dried between
the time of placing is more short better; After section
rapidlyit is also reasonable method that input boiling water or microwave press down enzyme.
● in the technical scheme of CN101223985A " a kind of production technology that promotes desertliving cistanche sheet quality ", explicitly call for: (1) selects fresh herba cistanches fleshy stem (2) selected raw material is placed in to rinsing bowl cold rinse ... by microwave heating high-temperature, carry out enzyme (3) ... rapid draing (4)
above technological process completed in 20-120 minute
In addition, at the fresh Cistanche Tubulosa processing technique of < < > > (Cai Hong etc., China's Chinese medicine magazine, the 32nd the 13rd phase of volume of July in 2007, 1289-1291 page), CN101485731A " a kind of processing method that improves ingredient content of phenylethanoid glycosides in fresh Chinese medicine desertliving cistanche ", CN102526212 " a kind of drying and processing method of Herba Cistanches ", in the prior aries such as CN 1709292 " improves the processing method of the Herba Cistanches medical material of echinacoside content ", also all first fresh herba cistanches is killed after enzyme processing, carry out again following process.
Summary of the invention
The object of the invention is to provide a kind of new desertliving cistanche sheet processing technique, and this process distinction, in prior art, can improve the content of phenylethanoid glycoside in Herba Cistanches to a greater extent.
Technical solution of the present invention is a kind of processing method of desertliving cistanche sheet, and the method comprises the steps: to excavate after fresh herba cistanches, and cutting is 2-4 part, kills enzyme and processes, and section, dry, makes decoction pieces and get final product.
Preferably, described processing method comprises the steps: to excavate after fresh herba cistanches, and cutting is 2-4 part, places 4-6 days, then kills enzyme and processes, then make according to a conventional method decoction pieces and get final product.
Wherein, described cutting refers to longitudinal incision, and the temperature conditions that medical material is placed is 18-25 ℃, and the described method of enzymatically treating that kills is water steaming, decocting in water or microwave heating.
Final preferred processing method comprises the steps: to excavate after fresh herba cistanches, and rip cutting is 2-4 part, is placed under 18-25 ℃ of condition and places 4-6 days, then cuts 5mm sheet, and water steams 10 minutes, then with 60-80 ℃ of oven dry, obtains.
The present invention breaks through the traditional understanding of prior art, is not only eager to kill enzyme and processes, and after medical material being carried out to physical stimulation (rip cutting or crosscut), also will place 4-6 days on the contrary, then kills enzyme again, is dried, makes decoction pieces.Inventor the experiment proved that, the phenylethanoid glycoside in Herba Cistanches stands not only can be on the contrary content ascendant trend by enzymolysis in post-stimulatory 4-6 days at medical material, just can reduce gradually afterwards.Therefore, giving the certain physical stimulation of Herba Cistanches medical material, and certain placement environment is provided, kill in time more afterwards enzyme and process, is the key that improves desertliving cistanche sheet quality.
Experimentation and beneficial effect: the impact of different processing methods on effective ingredient in fresh meat Herba Cistanches
One, experiment condition:
1, liquid-phase condition:
Instrument: Thermo Ultimate 3000 chromatograph of liquid;
Chromatographic column: Agilent XDB-C18column (5 μ m, 4.6 * 250mm);
Column temperature: 30 ℃;
Flow velocity: 1mL/min;
Sample size: 10 μ L;
Mobile phase: methanol-0.1% formic acid water, gradient elution;
Elution program: 0-30min:30%-40%; 30-35min:40%-30%; 35-40min:30% methanol.
2, the preparation method of need testing solution: precision takes the Herba Cistanches sample powder that 1g is dry (crossing 50 mesh sieves), put in 50mL tool plug conical flask, add 70% methanol 50mL, weigh, soak 30min, after ultrasonic 30min, weigh again and supply weight, after standing letting cool, get extracting solution 1mL, filter, get supernatant and cross 0.45 μ m microporous filter membrane, be stored in 4 ℃ of refrigerators, standby.
3, the preparation method of reference substance solution: accurate draw echinacoside, cistanoside A, verbascoside, 2 '-acetyl group verbascoside each 1.57,1.08,1.17,1.03mg; put in same 5mL measuring bottle with 70% dissolve with methanol and be diluted to scale; be stored in 4 ℃ of refrigerators, standby.
4, assay method: get above-mentioned need testing solution, each 10 μ L of reference substance solution, injection liquid chromatography is analyzed respectively, obtains.
Two, experiment content and method:
1, the comparison of different dry drying method
To after Herba Cistanches rip cutting, be divided into 4 parts, by 1 part of direct lyophilization wherein, other 3 parts adopt respectively dry, 60 ℃ dry and 80 ℃ of drying modes dry.Measure respectively the active constituent content in four duplicate samples, the results are shown in following table.
From upper table, in the situation that not taking to kill enzymatic process, 3 kinds of drying meanss all can cause the obvious minimizing of effective ingredient, but will obviously be better than drying with 60-80 ℃ of drying means.
2, difference is killed the comparison of enzyme method
To after Herba Cistanches rip cutting, be divided into 4 parts, cut respectively 5mm left and right sheet, by 1 part of direct lyophilizing wherein, all the other 3 parts adopt respectively water steaming 10 minutes, decocting in water 1 minute and the 800W microwave heating method of 2 minutes to kill after enzyme, put 70 ℃ of oven dry.Measure respectively the active constituent content in four duplicate samples, the results are shown in following table.
From upper table, 3 kinds are killed enzyme method and kill 70 ℃ of oven dry after enzyme, all can cause effective ingredient loss in various degree, but that water steams the method loss amount of 10min is minimum, are better than other 2 kinds of methods.
3, standing time length comparison
(1) room temperature is placed
To after Herba Cistanches rip cutting, be divided into 8 parts, at room temperature condition (18-25 ℃), place different number of days respectively, get 1 part every day and out cut sheet lyophilization, measure active constituent content.This experiment is repeated 3 times, the results are shown in following table (the 8th day result slightly).
The 1st experimental result
The 2nd experimental result
The 3rd experimental result
From result: each active constituent content all presents peak valley formula in put procedure to be changed, wherein echinacoside, cistanoside A changes of contents degree a little less than, and verbascoside changes obvious with 2-acetyl group verbascoside.Overall merit, it is maximum that Herba Cistanches active constituent content reaches when depositing 4-6 days, occurs that obviously decay and medical material have obviously to go mouldy after 6 days, and the therefore best resting period should be 4-6 days.
Place for (2) 4 ℃ and investigate
For further verifying above-mentioned experiment conclusion, inventor has also investigated the changes of contents situation of each composition under 4 ℃ of storage conditions, the results are shown in following table.
Experimental result for the first time
Experimental result for the second time
Result shows, the situation of change of each active constituent content has identical Changing Pattern when 4 ℃ of placements are placed with room temperature.Although be difficult for going mouldy in the time of 4 ℃, production cost can obviously increase, so not as optimal conditions.
4, the comparison of crosscut and rip cutting
Get 30 of the sizable Herba Cistanches simultaneously excavated in the same place of production, be divided at random 3 groups, 10 every group.By the 1st group of direct slicing lyophilization, measure content; By the 2nd group respectively rip cutting be 4 parts, laterally cut respectively sheet by the 3rd group, all at shady and cool ventilation place, place 4 days, then lyophilization, measure respectively active constituent content.The changes of contents situation of each group, sees the following form.
From upper table, no matter crosscut or rip cutting, all can produce positive stimulation to the variation of Herba Cistanches effective ingredient, but the effect of rip cutting is more remarkable.
The specific embodiment
Embodiment 1: excavate after fresh herba cistanches, crosscut is 2-4 section, and then dry in the sun 4 days is killed enzyme in 2 minutes with 800W microwave heating, then be cut into sheet, continues to dry, and obtains desertliving cistanche sheet.
Embodiment 2: excavate after fresh herba cistanches, crosscut is 2-4 section, places at ambient temperature 5 days, are then cut into the sheet of 4mm left and right, with hot water, boil and within 1 minute, kill enzyme, and 60 ℃ of oven dry, obtain desertliving cistanche sheet.
Embodiment 3: excavate after fresh herba cistanches, crosscut is the sheet of 5mm left and right, place at ambient temperature 4 days, then steam and within 10 minutes, kill enzyme with hot water, and 70 ℃ of oven dry, obtain desertliving cistanche sheet.
Embodiment 4: excavate after fresh herba cistanches, rip cutting is 2-4 part, places 6 days in fresh-keeping warehouse, then are cut into the sheet of 5mm left and right, with steam heating, within 10 minutes, kill enzyme, and 80 ℃ of oven dry, obtain desertliving cistanche sheet.
Embodiment 5: excavate after fresh herba cistanches, rip cutting is 2-4 part, are placed under shady and cool dry place (temperature 18-25 ℃, humidity 10%-40%) condition and place 5 days, then cut 5mm sheet, steam 10 minutes, then with 70 ℃ of oven dry, obtain desertliving cistanche sheet with hot water.
Claims (7)
1. can improve a production and processing method for desertliving cistanche sheet quality, it is characterized in that the method comprises the steps: to excavate after fresh herba cistanches, cutting is 2-4 part, kills enzyme and processes, and section, dry, makes decoction pieces and get final product.
2. can improve a production and processing method for desertliving cistanche sheet quality, it is characterized in that the method comprises the steps: to excavate after fresh herba cistanches, cutting is 2-4 part, places 4-6 days, then kills enzyme and processes, then make according to a conventional method decoction pieces and get final product.
3. processing method according to claim 2, is characterized in that described cutting refers to longitudinal incision.
4. processing method according to claim 2, is characterized in that the temperature conditions that medical material is placed is 18-25 ℃.
5. processing method according to claim 2, is characterized in that the described method of enzymatically treating that kills is water steaming, decocting in water or microwave heating.
6. according to the processing method described in any one in claim 2 to 5, it is characterized in that the method comprises the steps: to excavate after fresh herba cistanches, rip cutting is 2-4 part, be placed under 18-25 ℃ of condition and place 4-6 days, then cut 5mm sheet, water steams 10 minutes, with 60-80 ℃ of oven dry, obtain again.
7. the desertliving cistanche sheet making according to method described in any one in claim 1-6.
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| CN201410392733.4A CN104127506B (en) | 2014-08-11 | 2014-08-11 | A kind of production and processing method that can improve desertliving cistanche sheet quality |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105902620A (en) * | 2016-03-18 | 2016-08-31 | 内蒙古王爷地苁蓉生物有限公司 | Fresh cistanche decoction piece and preparation method thereof |
| CN106692311A (en) * | 2016-12-23 | 2017-05-24 | 庆阳敦博科技发展有限公司 | Processing method of herba cistanche tablet |
| CN112618599A (en) * | 2019-09-24 | 2021-04-09 | 宁夏农林科学院农业生物技术研究中心（宁夏农业生物技术重点实验室） | Fresh and dry cistanche slice processing method and product thereof |
| CN115068522A (en) * | 2022-06-15 | 2022-09-20 | 内蒙古三口生物科技有限公司 | Cistanche aqueous extract and preparation method and application thereof |
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| CN103211871A (en) * | 2012-01-24 | 2013-07-24 | 贺文军 | Processing technology of freeze drying and fresh-keeping of cistanche |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101485731A (en) * | 2008-01-16 | 2009-07-22 | 杏辉天力（杭州）药业有限公司 | Processing method for improving ingredient content of phenylethanoid glycosides in fresh Chinese medicine desertliving cistanche |
| CN103211871A (en) * | 2012-01-24 | 2013-07-24 | 贺文军 | Processing technology of freeze drying and fresh-keeping of cistanche |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105902620A (en) * | 2016-03-18 | 2016-08-31 | 内蒙古王爷地苁蓉生物有限公司 | Fresh cistanche decoction piece and preparation method thereof |
| CN106692311A (en) * | 2016-12-23 | 2017-05-24 | 庆阳敦博科技发展有限公司 | Processing method of herba cistanche tablet |
| CN112618599A (en) * | 2019-09-24 | 2021-04-09 | 宁夏农林科学院农业生物技术研究中心（宁夏农业生物技术重点实验室） | Fresh and dry cistanche slice processing method and product thereof |
| CN115068522A (en) * | 2022-06-15 | 2022-09-20 | 内蒙古三口生物科技有限公司 | Cistanche aqueous extract and preparation method and application thereof |
| CN115068522B (en) * | 2022-06-15 | 2023-09-12 | 内蒙古三口生物科技有限公司 | Cistanche deserticola water extract and preparation method and application thereof |
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