CN101219166B - Cistanche salsa processing method for improving phenyl ethyl alcohol glycosides compounds content - Google Patents
Cistanche salsa processing method for improving phenyl ethyl alcohol glycosides compounds content Download PDFInfo
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- CN101219166B CN101219166B CN2007100328020A CN200710032802A CN101219166B CN 101219166 B CN101219166 B CN 101219166B CN 2007100328020 A CN2007100328020 A CN 2007100328020A CN 200710032802 A CN200710032802 A CN 200710032802A CN 101219166 B CN101219166 B CN 101219166B
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- 229930182470 glycoside Natural products 0.000 title claims abstract description 32
- -1 phenyl ethyl alcohol glycosides compounds Chemical class 0.000 title claims abstract description 32
- WRMNZCZEMHIOCP-UHFFFAOYSA-N 2-Phenylethanol Natural products OCCC1=CC=CC=C1 WRMNZCZEMHIOCP-UHFFFAOYSA-N 0.000 title claims abstract description 28
- 238000003672 processing method Methods 0.000 title claims abstract description 8
- 241000336315 Cistanche salsa Species 0.000 title claims description 5
- 229940067107 phenylethyl alcohol Drugs 0.000 title 1
- 241000005787 Cistanche Species 0.000 claims abstract description 156
- 238000000034 method Methods 0.000 claims abstract description 49
- 238000001035 drying Methods 0.000 claims abstract description 42
- 239000002994 raw material Substances 0.000 claims abstract description 40
- 150000001875 compounds Chemical class 0.000 claims abstract description 30
- 239000000463 material Substances 0.000 claims abstract description 25
- FSBUXLDOLNLABB-ISAKITKMSA-N echinacoside Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1O[C@H]1[C@H](OC(=O)\C=C\C=2C=C(O)C(O)=CC=2)[C@@H](CO[C@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)O[C@@H](OCCC=2C=C(O)C(O)=CC=2)[C@@H]1O FSBUXLDOLNLABB-ISAKITKMSA-N 0.000 claims abstract description 23
- NJYVDFDTLLZVMG-UHFFFAOYSA-N echinacoside Natural products CC1OC(OC2C(O)C(OCCc3ccc(O)c(O)c3)OC(COC4OC(CO)C(O)C(O)C4O)C2OC(=O)C=Cc5cc(O)cc(O)c5)C(O)C(O)C1O NJYVDFDTLLZVMG-UHFFFAOYSA-N 0.000 claims abstract description 23
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 21
- 239000000843 powder Substances 0.000 claims abstract description 20
- 230000010354 integration Effects 0.000 claims abstract description 17
- 230000001954 sterilising effect Effects 0.000 claims abstract description 10
- 238000004659 sterilization and disinfection Methods 0.000 claims abstract description 10
- 210000004027 cell Anatomy 0.000 claims description 37
- 238000005516 engineering process Methods 0.000 claims description 36
- 238000003801 milling Methods 0.000 claims description 32
- 230000000694 effects Effects 0.000 claims description 26
- 239000012141 concentrate Substances 0.000 claims description 24
- 210000000805 cytoplasm Anatomy 0.000 claims description 23
- 102000004190 Enzymes Human genes 0.000 claims description 21
- 108090000790 Enzymes Proteins 0.000 claims description 21
- 235000010599 Verbascum thapsus Nutrition 0.000 claims description 21
- 229930182478 glucoside Natural products 0.000 claims description 21
- 150000008131 glucosides Chemical class 0.000 claims description 21
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 20
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 20
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 18
- 239000000203 mixture Substances 0.000 claims description 16
- 239000002002 slurry Substances 0.000 claims description 15
- 238000004458 analytical method Methods 0.000 claims description 13
- GEHJYWRUCIMESM-UHFFFAOYSA-L sodium sulfite Chemical compound [Na+].[Na+].[O-]S([O-])=O GEHJYWRUCIMESM-UHFFFAOYSA-L 0.000 claims description 12
- 238000001694 spray drying Methods 0.000 claims description 11
- 235000010323 ascorbic acid Nutrition 0.000 claims description 10
- 229960005070 ascorbic acid Drugs 0.000 claims description 10
- 239000011668 ascorbic acid Substances 0.000 claims description 10
- JEGUKCSWCFPDGT-UHFFFAOYSA-N h2o hydrate Chemical compound O.O JEGUKCSWCFPDGT-UHFFFAOYSA-N 0.000 claims description 10
- 239000007788 liquid Substances 0.000 claims description 10
- 229910052757 nitrogen Inorganic materials 0.000 claims description 10
- 239000007787 solid Substances 0.000 claims description 10
- PHOQVHQSTUBQQK-SQOUGZDYSA-N D-glucono-1,5-lactone Chemical compound OC[C@H]1OC(=O)[C@H](O)[C@@H](O)[C@@H]1O PHOQVHQSTUBQQK-SQOUGZDYSA-N 0.000 claims description 9
- 238000001704 evaporation Methods 0.000 claims description 9
- 239000002245 particle Substances 0.000 claims description 8
- 238000004321 preservation Methods 0.000 claims description 8
- 241000336316 Cistanche tubulosa Species 0.000 claims description 7
- HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 claims description 7
- 235000010262 sodium metabisulphite Nutrition 0.000 claims description 7
- 239000010408 film Substances 0.000 claims description 6
- 235000013305 food Nutrition 0.000 claims description 6
- 235000010265 sodium sulphite Nutrition 0.000 claims description 6
- 241000308150 Orobanchaceae Species 0.000 claims description 5
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- 150000003839 salts Chemical class 0.000 claims description 5
- 241000985690 Cistanche sinensis Species 0.000 claims description 4
- 238000007710 freezing Methods 0.000 claims description 4
- 241000336291 Cistanche deserticola Species 0.000 claims description 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 3
- 230000008020 evaporation Effects 0.000 claims description 3
- 239000011780 sodium chloride Substances 0.000 claims description 3
- 239000010409 thin film Substances 0.000 claims description 3
- 244000178289 Verbascum thapsus Species 0.000 claims 1
- 238000006555 catalytic reaction Methods 0.000 abstract description 6
- QFRYQWYZSQDFOS-UHFFFAOYSA-N verbascoside Natural products CC1OC(COC2C(O)C(COC3OC(C(O)C(O)C3O)C(=O)O)OC(Oc4cc(O)cc5OC(=CC(=O)c45)c6ccc(O)c(O)c6)C2O)C(O)C(O)C1O QFRYQWYZSQDFOS-UHFFFAOYSA-N 0.000 abstract description 5
- 239000004480 active ingredient Substances 0.000 abstract description 4
- 238000004519 manufacturing process Methods 0.000 abstract description 4
- KDSWDGKIENPKLB-QJDQKFITSA-N verbascoside Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1O[C@H]1[C@H](OC(=O)CCC=2C=C(O)C(O)=CC=2)[C@@H](CO)O[C@@H](OCCC=2C=C(O)C(O)=CC=2)[C@@H]1O KDSWDGKIENPKLB-QJDQKFITSA-N 0.000 abstract description 3
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- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- 229930185474 acteoside Natural products 0.000 description 2
- FBSKJMQYURKNSU-ZLSOWSIRSA-N acteoside Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1O[C@H]1[C@H](OC(=O)\C=C\C=2C=C(O)C(O)=CC=2)[C@@H](CO)O[C@@H](OCCC=2C=C(O)C(O)=CC=2)[C@@H]1O FBSKJMQYURKNSU-ZLSOWSIRSA-N 0.000 description 2
- FBSKJMQYURKNSU-UKQWSTALSA-N acteoside I Natural products C[C@@H]1O[C@H](O[C@@H]2[C@@H](O)[C@H](OCCc3ccc(O)c(O)c3)O[C@H](CO)[C@H]2OC(=O)C=Cc4ccc(O)c(O)c4)[C@H](O)[C@H](O)[C@H]1O FBSKJMQYURKNSU-UKQWSTALSA-N 0.000 description 2
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- 229910052708 sodium Inorganic materials 0.000 description 2
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- MRIFZKMKTDPBHR-XLOWEYQUSA-N 8-Epiiridotrial glucoside Chemical compound O([C@H]1[C@H]2[C@@H](C(=CO1)C=O)CC[C@H]2C)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O MRIFZKMKTDPBHR-XLOWEYQUSA-N 0.000 description 1
- 208000024827 Alzheimer disease Diseases 0.000 description 1
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- 102000030523 Catechol oxidase Human genes 0.000 description 1
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- MRIFZKMKTDPBHR-UHFFFAOYSA-N boschnaloside Natural products CC1CCC(C(=CO2)C=O)C1C2OC1OC(CO)C(O)C(O)C1O MRIFZKMKTDPBHR-UHFFFAOYSA-N 0.000 description 1
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Landscapes
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention provides a processing method that remarkably improves the medicinal value of herba cistanches and the content of an active ingredient phenethyl alcohol glycosides compound through system integration technique. A process of finishing the manufacturing process of a fresh stem of the herba cistanches from fresh herba cistanches raw material feeding to the acquisition of herba cistanches powder is realized within 15-45min through the application of system integration technique, such as cell disruption, high-temperature sterilization, spray and drying, etc., thus effectively inhibiting, interdicting and overcoming the technical defects that active ingredients, such as the henethyl alcohol glycosides compound, are severely degraded and lost caused by enzymic catalytic reaction arising from general improper herba cistanches drying and processing method. According to analytic determination, the content of active ingredients, such as the henethyl alcohol glycosides compound is high in the acquired herba cistanches powder material, wherein, echinacoside and verbascoside monomeric compound, which are major index for herba cistanches quality, the yield is as high as 15 percent-24 percent (calculated by dry matter), and the water content is 0.6 percent to 3.1 percent.
Description
Technical field
The present invention relates to a kind of Herba Cistanches processing method that promotes the phenethyl alcohol glycoside kind compound content.
Background technology
Herba Cistanches (Herba Cistanches) is famous traditional tonic medicine, has effects such as beneficial vital essence, reinforcing the kidney and supporting YANG and slow down aging, is the highest kidney-replenishing medicine of successive dynasties traditional Chinese medical science usage frequency." Herba Cistanches that records of Chinese pharmacopoeia version in 2005 is the chylocaulous of Orobanchaceae plant Cistanche deserticola Y.C.Ma and Cistanche Tubulosa Cistanche tubulosa (Schrenk) Wight dry zone scale leaf.The Compendium of Material Medica record " Herba Cistanches cures mainly five kinds of strain and seven kinds of impairment, and invigorating middle warmer removes cold and heat carbuncle in the stem, supports the five internal organs, reinforcing YIN-essence, and tonifying YANG, beneficial vital essence, how sub.Fu Ren mass in the abdomen, clothes are made light of one's life by commiting suicide for a long time.Remove bladder pathogen lumbago, dysentery relieving.The benefit marrow, improving healthy complexion is prolonged life, and mends tonifying YANG greatly, and day was driven letter, controlled woman's metrorrhagia.The man is exhausted, and sun is out of fashion, and the woman is exhausted, and the moon does not produce.Moistening five ZANG-organs, longue meat, warm waist knee joint.The man lets out smart urine, and blood is lost drop, the cloudy carbuncle of woman's leukorrhagia.The mutually fiery not enough person of the gate of vitality mends it with this, be kidney channel blood system medicine also ... ".Successive dynasties Confucian classics record, the Herba Cistanches property of medicine is gentle, mends and not high, supports and not dry, has the effect of kidney-replenishing, benefiting essence-blood, loosening bowel to relieve constipation; Be used for the treatment of diseases such as sexual impotence, infertile, soreness of the waist and knees, muscles and bones are unable, constipation.Modern study shows that the main active ingredient of Herba Cistanches is phenethyl alcohol glycosides, iridoid glycosides, lignanoid's glycoside, oligosaccharide esters and polyhydric alcohol etc.Phenethyl alcohol glycosides (Phenylethanoid Glycosides, Ph Gs) chemical compound comprise boschnaloside, echinacoside (echinacosid), verbascoside (acteoside or acteoside), 2 '-materials such as acetyl group verbascoside.And echinacoside and mullein glucoside monomeric compound are the higher phenethyl alcohol glycoside compounds of content in the Herba Cistanches chylocaulous, and these two kinds of representative active component are as the leading indicator of estimating the Herba Cistanches quality at present.Pharmaceutical research shows that echinacoside and mullein glucoside monomeric compound have the effect of anti-senile dementia disease and the effect of obvious hypermnesis.
Fresh herba cistanches chylocaulous moisture surpasses 80% usually, and the course of processing is difficult for dry.Traditional diamond-making technique adopts the fresh herba cistanches chylocaulous placed under the sunlight always and dries, or shady and cool place dries in the shade, or dries behind the salting, or dries after the stripping and slicing, section etc., and technology falls behind, and dry run is very slow, short then two weeks, long then one to two moon.Discover that containing a large amount of K, Na, Ca, Fe etc. in the Herba Cistanches has the metal ion of activation, wherein K to the enzyme catalysis vigor
+Concentration is up to 0.3%～2.3%, Na
+Concentration is up to 0.1%～1.7%, Ca
2+Concentration is up to 0.03%～0.36%, Fe
3+Concentration is up to 0.005%～0.14%, particularly there is abundant enzymes such as hydrolytic enzyme, glycoside hydrolase and polyphenol oxidase system in the fresh herba cistanches chylocaulous, the dried process is because undried Herba Cistanches is in bad dried environment such as moistening, damp and hot for a long time, and in the course of processing because of reasons such as physical damnifications, the enzyme that is activated causes active enzymic catalytic reaction rapidly and produces enzymatic browning, the phenethyl alcohol glycoside compounds isoreactivity composition that causes Herba Cistanches to be rich in is hydrolyzed, degrades, transforms or synthetic new product at enzyme-catalyzed reaction.Testing result shows, just echinacoside and mullein glucoside monomeric compound content are very abundant in the fresh herba cistanches chylocaulous of being unearthed, can be up to 24.3% (in dry), but different processing modes reaches from the place of production, kind, in the different desertliving cistanche sheet samples of collecting of host and collection season, echinacoside and mullein glucoside monomeric compound content only are 0.03%～1.0%, the active component phenethyl alcohol glycoside compounds that Herba Cistanches is rich in conventional processes is by severely degrade, and wherein representative active component echinacoside and mullein glucoside monomeric compound attenuation rate are up to 92.31%～99.87%.Discover, bad processing technique and drying method are that the primase catalytic reaction causes the active component phenethyl alcohol glycosides degradation loss that Herba Cistanches is rich in, particularly the key factor of two kinds of representative active component echinacoside and the loss of mullein glucoside monomeric compound severely degrade.
Summary of the invention
The purpose of this invention is to provide a kind of Herba Cistanches processing method that promotes the phenethyl alcohol glycoside kind compound content.
The present invention proposes a kind of system integration technology of passing through, significantly promote the processing method of Herba Cistanches medical value and active component phenethyl alcohol glycoside kind compound content, the fresh herba cistanches chylocaulous is passed through cell breakage technology, high temperature enzyme denaturing technology, the enforcement of system integration technologies such as drying process with atomizing, be implemented in and finish in 15～45 minutes the fresh herba cistanches raw material from being dosed to the technology manufacture process of obtaining the Herba Cistanches powder, effectively containment, blocking-up and overcome the technological deficiency that the phenethyl alcohol glycoside compounds isoreactivity composition that enzymic catalytic reaction caused that common Herba Cistanches causes at bad drying method is lost by severely degrade, phenethyl alcohol glycoside compounds isoreactivity component content significantly promotes than traditional processing mode in the Herba Cistanches powder of being gathered in the crops, and increases substantially the quality and the medical value of Herba Cistanches medical material.
Method of the present invention is, selects the fresh herba cistanches chylocaulous, or adopts and place the fresh-keeping fresh herba cistanches chylocaulous of industrial freezer, or adopts the quick-freezing Herba Cistanches chylocaulous of industrial freezer cold preservation, or selects for use selected Herba Cistanches chylocaulous and particle as raw material; Raw material is placed the rinsing bowl cold rinse, or with industrial pure water rinsing; After picking up, place common industrial breaker and milling device that the Herba Cistanches chylocaulous is broken and mill, make cell cracked; Broken and mill the technical process Material control at low temperature environment below 20 ℃, also can adopt to charge into common food grade liquid nitrogen or CO
2, or add CO
2Frozen water also can add micro-food grade ascorbic acid, citric acid, gluconic acid lactone, sodium sulfite, sodium pyrosulfite etc.; With the Herba Cistanches cell slurry after milling, or adopt common industrial instantaneous ultrahigh-temperature sterilization technology; Or adopt common industrial vacuum concentration technology, or the thin film evaporation concentration technology, the acquisition solid content is 35%～65% Herba Cistanches cytoplasm concentrate; Adopt common industrial drying process with atomizing, utilize high temperature drying steam that the cell slurry or the instantaneous processing of cytoplasm concentrate superhigh temperature of atomizing are made the enzyme activity forfeiture and obtain the instantaneous exsiccant effect of superhigh temperature; Above system integration technology flow process was finished in 15～45 minutes; Measure by analysis, phenethyl alcohol glycoside compounds isoreactivity content of material is abundant in the Herba Cistanches powder of results, wherein weigh the leading indicator composition echinacoside of Herba Cistanches quality and mullein glucoside monomeric compound productive rate up to 15%～24% (in dry), moisture is 0.6%～3.1%.
The Herba Cistanches cytoplasm concentrate that the inventive method is obtained also can adopt usually the method for other industrially drying to obtain powder, as industrial cylinder dry, microwave vacuum drying, microwave drying, vacuum drying, lyophilization and hot air drying etc.
The fresh-keeping storehouse temperature of employing industry freezer that the inventive method relates to is 1 ℃～13 ℃, and best freezer fresh-keeping warehouse temperature is 4 ℃～10 ℃; Adopting the storehouse temperature of industrial freezer cold preservation is-48 ℃～-10 ℃, and the storehouse temperature of best freezer cold preservation is-36 ℃～-18 ℃; The cold water water temperature that places the tank rinsing that adopts is 1 ℃～20 ℃, and best cold water water temperature is 4 ℃～10 ℃; That adopts charges into liquid nitrogen or CO in the Herba Cistanches raw material
2Concentration be 0.1%～5.0% (weight ratio), optium concentration is 0.5%～1% (weight ratio); That adopts adds CO in the Herba Cistanches raw material
2The frozen water amount is 1%～20% (weight ratio), CO
2CO in the frozen water
2Concentration is 0.1%～5.0% (weight ratio), CO
2The frozen water temperature is 1 ℃～20 ℃, CO
2Optimum temperature is 4 ℃～6 ℃ in the frozen water, CO
2CO in the frozen water
2Optium concentration is 1%～2% (weight ratio); Ascorbic acid, citric acid, gluconic acid lactone, sodium sulfite, the sodium pyrosulfite of the interpolation trace that adopts are food grade, addition is 0.001%～0.02% (weight ratio), optimum addition is 0.002%～0.005% (weight ratio), can select one or more for use; The temperature that the industrial instantaneous ultrahigh-temperature sterilization device technique that adopts carries out the instantaneous enzyme denaturing of superhigh temperature is 135 ℃～141 ℃; The industrial vacuum concentration technology that adopts and the temperature of industrial film evaporating and concentrating process are 45 ℃～65 ℃; It is 120 ℃～280 ℃ that the instantaneous processing of adopting of industrial drying process with atomizing drying tower superhigh temperature makes the temperature of enzyme activity forfeiture and the instantaneous exsiccant effect of acquisition superhigh temperature, and best temperature is 180 ℃～210 ℃.
The Herba Cistanches that the present invention relates to is Orobanchaceae plant (Orobanchaceae) Herba Cistanches or claims Desert Herba Cistanches (Cistanchedeserticola Y.C.Ma), Cistanche Tubulosa (Cistanche tubulosa (Schrenk) R.Wight), spend salt Herba Cistanches (Cistanche salsa var.albiflora P.F.Tu et Z.C.Lou) in vain, the Herba Cistanches chylocaulous of the fresh band scale leaf of one or more in Saline Cistanche Herb (Cistanche salsa (C.A.Mey) G.Beck) and Herba Cistanches sinensis or the title C.sinensis G.Beck (Cistanche sinensis G.Beck), or through the fresh-keeping fresh herba cistanches chylocaulous of freezer, or the quick-freezing Herba Cistanches chylocaulous of freezer cold preservation, or select selected Herba Cistanches chylocaulous and particle for use.
The Herba Cistanches powder that the inventive method is produced, can be directly as products such as raw material production capsule, tablet, granule, electuary, pill or teabag, also can provide as medical material, or through further many kinds of extract and separate monomeric compound or extract, or through further many kinds of extract and separate monomeric compound or extract.
The concrete steps of the inventive method comprise:
1, select the fresh herba cistanches chylocaulous, or adopt and to place the fresh-keeping fresh herba cistanches chylocaulous of industrial freezer, or adopt the quick-freezing Herba Cistanches chylocaulous of industrial freezer cold preservation, or selected Herba Cistanches chylocaulous and particle is as raw material.
2, selected raw material is placed the rinsing bowl cold rinse, or, after picking up, place common industrial breaker and milling device with industrial pure water rinsing, the Herba Cistanches chylocaulous is broken and mill, make cell cracked; Broken and mill the technical process Material control at low temperature environment below 20 ℃, also can adopt to charge into common food grade liquid nitrogen or CO
2, or add CO
2Frozen water also can add micro-food grade ascorbic acid, citric acid, gluconic acid lactone, sodium sulfite, sodium pyrosulfite etc.
3, the Herba Cistanches cell slurry after will milling adopts common industrial instantaneous ultrahigh-temperature sterilization technology; Or adopt common industrial vacuum concentration technology, or the thin film evaporation concentration technology, the acquisition solid content is 30%～70% Herba Cistanches cytoplasm concentrate;
4, adopt common industrial drying process with atomizing, utilize high temperature drying steam that the cell slurry or the instantaneous processing of cytoplasm concentrate superhigh temperature of atomizing are made the enzyme activity forfeiture and obtain the instantaneous exsiccant effect of superhigh temperature.
5, above system integration technology flow process was finished in 15～45 minutes; Measure by analysis, phenethyl alcohol glycoside compounds isoreactivity content of material is abundant in the Herba Cistanches powder of results, wherein weigh the leading indicator composition echinacoside of Herba Cistanches quality and mullein glucoside monomeric compound productive rate up to 15%～24% (in dry), moisture is 0.6%～3.1%.
The percentage ratio of the various amounts that relate among the present invention (%) all is weight percentage
Weighing the leading indicator composition echinacoside of Herba Cistanches quality and the productive rate of mullein glucoside monomeric compound in the product described in the present invention (the Herba Cistanches powders of results) is contained echinacoside and the amount of mullein glucoside monomeric compound and the percentage ratio (calculating with dry) of raw material gross weight in the product.
The specific embodiment
Below in conjunction with embodiment the present invention is described in further detail.
Embodiment one:
1, selects fresh tube flower herba cistanches chylocaulous as raw material;
2, raw material is placed the rinsing bowl cold rinse, the cold water water temperature is 5 ℃; After picking up, place common industrial breaker and milling device that the Herba Cistanches chylocaulous is broken and mill, make cell cracked; Broken and the technical process of milling charges into liquid nitrogen, and liquid nitrogen concentration is 1.0% (weight ratio) in the material; Recording temperature of charge is 16 ℃,
3, the Herba Cistanches cell slurry after will milling adopts common industrial drying process with atomizing, the dry tower body that connects at the spray drying tower nebulizer carries out drying by high temperature drying steam to the Herba Cistanches cell slurry of atomizing, and utilizes the instantaneous processing of superhigh temperature to make the enzyme activity forfeiture and the temperature that obtains the instantaneous exsiccant effect of superhigh temperature is 280 ℃.
5, above system integration technology flow process was finished in 15 minutes; Measure by analysis, phenethyl alcohol glycoside compounds isoreactivity content of material is abundant in the Herba Cistanches powder of results, wherein weigh the leading indicator composition echinacoside of Herba Cistanches quality and mullein glucoside monomeric compound productive rate up to 24% (in dry), moisture is 2.8%.
Embodiment two:
1, select that to place the storehouse temperature be the fresh-keeping Cistanche Tubulosa chylocaulous of 4 ℃ industrial freezer and spend salt Herba Cistanches chylocaulous in vain as raw material, ratio is 1: 1;
2, with raw material with industrial pure water rinsing, after picking up, place common industrial breaker and milling device that the Herba Cistanches chylocaulous is broken and mill, make cell cracked; Broken and the technical process of milling charges into CO
2, CO in the material
2Concentration is 0.5% (weight ratio), and is added into 0.002% ascorbic acid of raw material weight and 0.001% gluconic acid lactone (weight ratio); Recording temperature of charge is 10 ℃;
3, the Herba Cistanches cell slurry after will milling adopts common industrial instantaneous ultrahigh-temperature sterilization technology, and the temperature of the instantaneous enzyme denaturing of superhigh temperature is 141 ℃; And adopt common industrial film evaporating and concentrating process, obtain solid content and be 55% Herba Cistanches cytoplasm concentrate;
4, the cytoplasm concentrate is adopted common industrial drying process with atomizing, the dry tower body that connects at the spray drying tower nebulizer carries out drying by 120 ℃ of high temperature drying steam to the Herba Cistanches cell serosity that atomizes.
5, above system integration technology flow process was finished in 30 minutes; Measure by analysis, phenethyl alcohol glycoside compounds isoreactivity content of material is abundant in the Herba Cistanches powder of results, wherein weigh the leading indicator composition echinacoside of Herba Cistanches quality and mullein glucoside monomeric compound productive rate up to 18.6% (in dry), moisture is 2.8%.
Embodiment three:
1, select for use selected Herba Cistanches chylocaulous and particle as raw material;
2, raw material is placed the rinsing bowl cold rinse, the cold water water temperature is 4 ℃, after picking up, places common industrial breaker and milling device, and the Herba Cistanches chylocaulous is broken and mill, and makes cell cracked; Recording temperature of charge is 10 ℃;
3, the Herba Cistanches cell slurry after will milling adopts common industrial vacuum concentration technology, obtains solid content and be 40% Herba Cistanches cytoplasm concentrate;
4, the cytoplasm concentrate is adopted common industrial drying process with atomizing, the dry tower body that connects at the spray drying tower nebulizer makes the enzyme activity forfeiture and obtains the instantaneous exsiccant effect of superhigh temperature by the instantaneous processing of Herba Cistanches cell serosity concentrate superhigh temperature of 250 ℃ of high temperature drying steam to atomizing;
5, above system integration technology flow process was finished in 35 minutes; Measure by analysis, phenethyl alcohol glycoside compounds isoreactivity content of material is abundant in the Herba Cistanches powder of results, wherein weigh the leading indicator composition echinacoside of Herba Cistanches quality and mullein glucoside monomeric compound productive rate up to 16.3% (in dry), moisture is 1.8%.
Embodiment four:
1, selects fresh tube flower herba cistanches chylocaulous and particle as raw material;
2, raw material is placed the rinsing bowl cold rinse, the cold water water temperature is 6 ℃; After picking up, place common industrial breaker and milling device that the Herba Cistanches chylocaulous is broken and mill, make cell cracked; Recording temperature of charge is 14 ℃,
3, the Herba Cistanches cytoplasm after will milling adopts common industrial drying process with atomizing, the dry tower body that connects at the spray drying tower nebulizer carries out drying by high temperature drying steam to the Herba Cistanches cell slurry of atomizing, and utilizes the instantaneous processing of superhigh temperature to make the enzyme activity forfeiture and the temperature that obtains the instantaneous exsiccant effect of superhigh temperature is 210 ℃.
5, above system integration technology flow process was finished in 18 minutes; Measure by analysis, phenethyl alcohol glycoside compounds isoreactivity content of material is abundant in the Herba Cistanches powder of results, wherein weigh the leading indicator composition echinacoside of Herba Cistanches quality and mullein glucoside monomeric compound productive rate up to 22.1% (in dry), moisture is 2.65%.
Embodiment five:
1, select that to place the storehouse temperature be the fresh-keeping Herba Cistanches sinensis chylocaulous of 6 ℃ industrial freezer and spend salt Herba Cistanches chylocaulous in vain as raw material, ratio is 1: 1;
2, with raw material with industrial pure water rinsing, after picking up, place common industrial breaker and milling device that the Herba Cistanches chylocaulous is broken and mill, make cell cracked; Broken and the technical process of milling charges into CO
2, CO in the material
2Concentration is 0.5% (weight ratio), and is added into 0.001% ascorbic acid of raw material weight and 0.002% gluconic acid lactone (weight ratio); Recording temperature of charge is 18 ℃;
3, the Herba Cistanches cell slurry after will milling adopts common industrial instantaneous ultrahigh-temperature sterilization technology, and the temperature of the instantaneous enzyme denaturing of superhigh temperature is 141 ℃; And adopt common industrial film evaporating and concentrating process, obtain solid content and be 55% Herba Cistanches cytoplasm concentrate;
4, the cytoplasm concentrate is adopted common industrial drying process with atomizing, the dry tower body that connects at the spray drying tower nebulizer carries out drying by 120 ℃ of high temperature drying steam to the Herba Cistanches cell serosity that atomizes.
5, above system integration technology flow process was finished in 38 minutes; Measure by analysis, phenethyl alcohol glycoside compounds isoreactivity content of material is abundant in the Herba Cistanches powder of results, wherein weigh the leading indicator composition echinacoside of Herba Cistanches quality and mullein glucoside monomeric compound productive rate up to 18.6% (in dry), moisture is 2.3%.
Embodiment six:
1, select for use selected Herba Cistanches chylocaulous and particle as raw material;
2, raw material is placed the rinsing bowl cold rinse, the cold water water temperature is 2 ℃, after picking up, places common industrial breaker and milling device, and the Herba Cistanches chylocaulous is broken and mill, and makes cell cracked; Recording temperature of charge is 10 ℃;
3, the Herba Cistanches cell slurry after will milling adopts common industrial vacuum concentration technology, obtains solid content and be 40% Herba Cistanches cytoplasm concentrate;
4, the cytoplasm concentrate is adopted common industrial drying process with atomizing, the dry tower body that connects at the spray drying tower nebulizer makes the enzyme activity forfeiture and obtains the instantaneous exsiccant effect of superhigh temperature by the instantaneous processing of Herba Cistanches cell serosity concentrate superhigh temperature of 180 ℃ of high temperature drying steam to atomizing;
5, above system integration technology flow process was finished in 42 minutes; Measure by analysis, phenethyl alcohol glycoside compounds isoreactivity content of material is abundant in the Herba Cistanches powder of results, wherein weigh the leading indicator composition echinacoside of Herba Cistanches quality and mullein glucoside monomeric compound productive rate up to 16.3% (in dry), moisture is 1.7%.
Embodiment seven:
2, select fresh tube flower herba cistanches chylocaulous as raw material;
2, raw material is placed the rinsing bowl cold rinse, the cold water water temperature is 1 ℃; After picking up, place common industrial breaker and milling device that the Herba Cistanches chylocaulous is broken and mill, make cell cracked; Broken and the technical process of milling charges into liquid nitrogen, and liquid nitrogen concentration is 3.0% (weight ratio) in the material; Recording temperature of charge is 18 ℃,
3, the Herba Cistanches cytoplasm after will milling adopts common industrial drying process with atomizing, the dry tower body that connects at the spray drying tower nebulizer carries out drying by high temperature drying steam to the Herba Cistanches cell serosity of atomizing, and utilizes the instantaneous processing of superhigh temperature to make the enzyme activity forfeiture and the temperature that obtains the instantaneous exsiccant effect of superhigh temperature is 140 ℃.
5, above system integration technology flow process was finished in 18 minutes; Measure by analysis, phenethyl alcohol glycoside compounds isoreactivity content of material is abundant in the Herba Cistanches powder of results, wherein weigh the leading indicator composition echinacoside of Herba Cistanches quality and mullein glucoside monomeric compound productive rate up to 18.3% (in dry), moisture is 1.95%.
Embodiment eight:
1, select that to place the storehouse temperature be the fresh-keeping Cistanche Tubulosa chylocaulous of 4 ℃ industrial freezer and spend salt Herba Cistanches chylocaulous in vain as raw material, ratio is 1: 1;
2, with raw material with industrial pure water rinsing, after picking up, place common industrial breaker and milling device that the Herba Cistanches chylocaulous is broken and mill, make cell cracked; Broken and the technical process of milling charges into CO
2, CO in the material
2Concentration is 0.5% (weight ratio), and is added into 0.003% ascorbic acid of raw material weight and 0.001% sodium pyrosulfite (weight ratio); Recording temperature of charge is 10 ℃;
3, the Herba Cistanches cell slurry after will milling adopts common industrial instantaneous ultrahigh-temperature sterilization device technique, and the temperature of the instantaneous enzyme denaturing of superhigh temperature is 140 ℃; And adopt common industrial film evaporating and concentrating process, obtain solid content and be 45% Herba Cistanches cytoplasm concentrate;
4, the cytoplasm concentrate is adopted common industrial drying process with atomizing, the dry tower body that connects at the spray drying tower nebulizer carries out drying by 120 ℃ of high temperature drying steam to the Herba Cistanches cell serosity that atomizes.
5, above system integration technology flow process was finished in 30 minutes; Measure by analysis, phenethyl alcohol glycoside compounds isoreactivity content of material is abundant in the Herba Cistanches powder of results, wherein weigh the leading indicator composition echinacoside of Herba Cistanches quality and mullein glucoside monomeric compound productive rate up to 18.6% (in dry), moisture is 2.15%.
Embodiment nine:
1, select for use selected Herba Cistanches chylocaulous and particle as raw material;
2, raw material is placed the rinsing bowl cold rinse, the cold water water temperature is 10 ℃, after picking up, places common industrial breaker and milling device, and the Herba Cistanches chylocaulous is broken and mill, and makes cell cracked; Recording temperature of charge is 20 ℃;
3, the Herba Cistanches cell slurry after will milling adopts common industrial vacuum concentration technology, obtains solid content and be 45% Herba Cistanches cytoplasm concentrate;
4, the cytoplasm concentrate is adopted common industrial drying process with atomizing, the dry tower body that connects at the spray drying tower nebulizer makes the enzyme activity forfeiture and obtains the instantaneous exsiccant effect of superhigh temperature by the instantaneous processing of Herba Cistanches cell serosity concentrate superhigh temperature of 180 ℃ of high temperature drying steam to atomizing;
5, above system integration technology flow process was finished in 35 minutes; Measure by analysis, phenethyl alcohol glycoside compounds isoreactivity content of material is abundant in the Herba Cistanches powder of results, wherein weigh the leading indicator composition echinacoside of Herba Cistanches quality and mullein glucoside monomeric compound productive rate up to 16.3% (in dry), moisture is 3.1%.
Embodiment ten:
1, selects that to place the storehouse temperature be that the fresh-keeping Saline Cistanche Herb chylocaulous of 4 ℃ industrial freezer is as raw material;
2, with raw material with industrial pure water rinsing, after picking up, place common industrial breaker and milling device that the Herba Cistanches chylocaulous is broken and mill, make cell cracked; Broken and the technical process of milling charges into CO
2, CO in the material
2Concentration is 0.5% (weight ratio), and is added into 0.002% ascorbic acid of raw material weight and 0.001% gluconic acid lactone (weight ratio); Recording temperature of charge is 10 ℃;
3, the Herba Cistanches cell slurry after will milling adopts common industrial instantaneous ultrahigh-temperature sterilization device technique, and the temperature of the instantaneous enzyme denaturing of superhigh temperature is 141 ℃; And adopt common industrial film evaporating and concentrating process, obtain solid content and be 50% Herba Cistanches cytoplasm concentrate;
4, the cytoplasm concentrate is adopted common industrial drying process with atomizing, the dry tower body that connects at the spray drying tower nebulizer carries out drying by 135 ℃ of high temperature drying steam to the Herba Cistanches cell serosity that atomizes.
5, above system integration technology flow process was finished in 30 minutes; Measure by analysis, phenethyl alcohol glycoside compounds isoreactivity content of material is abundant in the Herba Cistanches powder of results, wherein weigh the leading indicator composition echinacoside of Herba Cistanches quality and mullein glucoside monomeric compound productive rate up to 18.6% (in dry), moisture is 0.6%.
Claims (4)
1. Herba Cistanches processing method that promotes the phenethyl alcohol glycoside kind compound content is characterized in that the concrete steps of this method comprise:
(1) selects the fresh herba cistanches chylocaulous, or adopt and to place the fresh-keeping fresh herba cistanches chylocaulous of industrial freezer, or adopt the quick-freezing Herba Cistanches chylocaulous of industrial freezer cold preservation, or select for use selected Herba Cistanches chylocaulous and particle as raw material; The fresh-keeping storehouse temperature of described industrial freezer is 1 ℃～13 ℃; The storehouse temperature of industry freezer cold preservation is-48 ℃～-10 ℃;
(2) selected raw material is placed the rinsing bowl cold rinse, or, after picking up, place common industrial breaker and milling device with industrial pure water rinsing, the Herba Cistanches chylocaulous is broken and mill, make cell cracked; Broken and mill the technical process Material control at low temperature environment below 20 ℃, or adopt and charge into common food grade liquid nitrogen or CO
2, or add CO
2Frozen water perhaps adds in the food grade ascorbic acid, citric acid, gluconic acid lactone, sodium sulfite, sodium pyrosulfite of trace one or more again; Cold water water temperature in the described tank is 1 ℃～20 ℃; Described liquid nitrogen or the CO of in the Herba Cistanches raw material, charging into
2Concentration be 0.1%～5.0% weight ratio, add CO
2The frozen water amount is 1%～20% weight ratio, CO
2CO in the frozen water
2Concentration is 0.1%～5.0% weight ratio, CO
2The frozen water temperature is 1 ℃～20 ℃; In the food grade ascorbic acid of described interpolation trace, citric acid, gluconic acid lactone, sodium sulfite, the sodium pyrosulfite one or more, addition is 0.001%～0.02% weight ratio;
(3) the Herba Cistanches cell slurry after will milling adopts common industrial instantaneous ultrahigh-temperature sterilization technology; Adopt common industrial vacuum concentration technology again, or the thin film evaporation concentration technology, the acquisition solid content is 30%～70% Herba Cistanches cytoplasm concentrate; The technological temperature of described industrial instantaneous ultrahigh-temperature sterilization is 135 ℃～141 ℃, and the temperature of industrial vacuum concentration technology and industrial film evaporating and concentrating process is 45 ℃～65 ℃;
(4) adopt common industrial drying process with atomizing, utilize high temperature drying steam that the instantaneous processing of cytoplasm concentrate superhigh temperature of atomizing is made the enzyme activity forfeiture and obtains the instantaneous exsiccant effect of superhigh temperature, temperature is 120 ℃～280 ℃;
(5), above system integration technology flow process was finished in 15～45 minutes; Measure by analysis, phenethyl alcohol glycoside compounds isoreactivity content of material is abundant in the Herba Cistanches powder of results, wherein weigh the leading indicator composition echinacoside of Herba Cistanches quality and mullein glucoside monomeric compound productive rate in dry up to 15%～24%, moisture is 0.6%～3.1%.
2. in accordance with the method for claim 1, it is characterized in that the Herba Cistanches described in the step (1) is Orobanchaceae plant (Orobanchaceae) Herba Cistanches or claims Desert Herba Cistanches (Cistanche deserticola Y.C.Ma), Cistanche Tubulosa (Cistanche tubulosa (Schrenk) R.Wight), spend salt Herba Cistanches (Cistanche salsa var.albiflora P.F.Tu et Z.C.Lou) in vain, in Saline Cistanche Herb (Cistanche salsa (C.A.Mey) G.Beck) and Herba Cistanches sinensis or the title C.sinensis G.Beck (Cistanche sinensis G.Beck) one or more.
3. in accordance with the method for claim 1, it is characterized in that the fresh-keeping storehouse temperature of the industrial freezer described in the step (1) is 4 ℃～10 ℃; The storehouse temperature of industry freezer cold preservation is-36 ℃～-18 ℃; Cold water water temperature described in the step (2) in the tank is 4 ℃～10 ℃; In the Herba Cistanches raw material, charge into liquid nitrogen or CO
2Concentration be 0.5%～1% weight ratio; In the Herba Cistanches raw material, add CO
2The frozen water temperature is 4 ℃～6 ℃; CO
2CO in the frozen water
2Concentration is 1%～2% weight ratio; Ascorbic acid, citric acid, gluconic acid lactone, sodium sulfite, the sodium pyrosulfite addition of the interpolation trace that adopts are 0.002%～0.005% weight ratio of raw material weight.
4. in accordance with the method for claim 1, it is characterized in that it is 180 ℃～210 ℃ that the instantaneous processing of spray drying superhigh temperature described in the step (4) makes the temperature of enzyme activity forfeiture and the instantaneous exsiccant effect of acquisition superhigh temperature.
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| CN101629197B (en) * | 2009-08-04 | 2011-11-16 | 中山大学 | Method for increasing content of acteoside in herba cistanches |
| CN101629198B (en) * | 2009-08-04 | 2011-12-21 | 中山大学 | Method for producing monomeric compounds of acteoside |
| CN103893274B (en) * | 2012-12-28 | 2016-04-27 | 中国医学科学院药用植物研究所 | A kind of concocting method of wine Herba Cistanches |
| CN106334001A (en) * | 2016-09-30 | 2017-01-18 | 宁夏医科大学 | Application of cistanche phenylethanoid glycosides effective part in preparation of bone formation accelerating drug and drug composition |
| CN106692311A (en) * | 2016-12-23 | 2017-05-24 | 庆阳敦博科技发展有限公司 | Processing method of herba cistanche tablet |
| CN109369739A (en) * | 2018-11-16 | 2019-02-22 | 山东省药学科学院 | A kind of walking fern plant extracts and preparation method thereof with brain protection activity |
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| 蔡鸿等.鲜管花肉苁蓉加工工艺.中国中药杂志32 13.2007,32(13),1289-1291. |
| 蔡鸿等.鲜管花肉苁蓉加工工艺.中国中药杂志32 13.2007,32(13),1289-1291. * |
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