CN104127370A - Oral folic acid instantly-dissolved membrane and preparation method thereof - Google Patents
Oral folic acid instantly-dissolved membrane and preparation method thereof Download PDFInfo
- Publication number
- CN104127370A CN104127370A CN201410378739.6A CN201410378739A CN104127370A CN 104127370 A CN104127370 A CN 104127370A CN 201410378739 A CN201410378739 A CN 201410378739A CN 104127370 A CN104127370 A CN 104127370A
- Authority
- CN
- China
- Prior art keywords
- folic acid
- preparation
- oral instant
- instant membrane
- filler
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 title claims abstract description 129
- 239000011724 folic acid Substances 0.000 title claims abstract description 65
- 235000019152 folic acid Nutrition 0.000 title claims abstract description 65
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 title claims abstract description 64
- 229960000304 folic acid Drugs 0.000 title claims abstract description 64
- 239000012528 membrane Substances 0.000 title claims abstract description 39
- 238000002360 preparation method Methods 0.000 title claims abstract description 24
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 19
- 230000008961 swelling Effects 0.000 claims abstract description 15
- 238000003756 stirring Methods 0.000 claims abstract description 13
- 239000000945 filler Substances 0.000 claims abstract description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 9
- 238000000034 method Methods 0.000 claims abstract description 8
- 239000004014 plasticizer Substances 0.000 claims abstract description 8
- 239000008213 purified water Substances 0.000 claims abstract description 8
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 24
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 14
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 14
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 14
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 14
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 12
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 10
- 229930195725 Mannitol Natural products 0.000 claims description 10
- 239000000594 mannitol Substances 0.000 claims description 10
- 235000010355 mannitol Nutrition 0.000 claims description 10
- 239000004376 Sucralose Substances 0.000 claims description 8
- 235000011187 glycerol Nutrition 0.000 claims description 8
- 235000019408 sucralose Nutrition 0.000 claims description 8
- BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 claims description 8
- IFNWPVOGRPXDCH-UHFFFAOYSA-N (3,5-dichloro-2,4-difluorophenyl)urea Chemical compound NC(=O)NC1=CC(Cl)=C(F)C(Cl)=C1F IFNWPVOGRPXDCH-UHFFFAOYSA-N 0.000 claims description 6
- 239000004375 Dextrin Substances 0.000 claims description 6
- 229920001353 Dextrin Polymers 0.000 claims description 6
- 229920000881 Modified starch Polymers 0.000 claims description 6
- 235000019425 dextrin Nutrition 0.000 claims description 6
- 108010011485 Aspartame Proteins 0.000 claims description 4
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims description 4
- 229920002565 Polyethylene Glycol 400 Polymers 0.000 claims description 4
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 4
- 229930006000 Sucrose Natural products 0.000 claims description 4
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 4
- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 claims description 4
- 239000000605 aspartame Substances 0.000 claims description 4
- 235000010357 aspartame Nutrition 0.000 claims description 4
- 229960003438 aspartame Drugs 0.000 claims description 4
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 4
- 229940031703 low substituted hydroxypropyl cellulose Drugs 0.000 claims description 4
- 239000008108 microcrystalline cellulose Substances 0.000 claims description 4
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims description 4
- 229940016286 microcrystalline cellulose Drugs 0.000 claims description 4
- JLFNLZLINWHATN-UHFFFAOYSA-N pentaethylene glycol Chemical compound OCCOCCOCCOCCOCCO JLFNLZLINWHATN-UHFFFAOYSA-N 0.000 claims description 4
- 239000001253 polyvinylpolypyrrolidone Substances 0.000 claims description 4
- 229920000523 polyvinylpolypyrrolidone Polymers 0.000 claims description 4
- 235000013809 polyvinylpolypyrrolidone Nutrition 0.000 claims description 4
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims description 4
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims description 4
- 239000005720 sucrose Substances 0.000 claims description 4
- 210000000214 mouth Anatomy 0.000 abstract description 7
- 239000003814 drug Substances 0.000 abstract description 4
- 235000019640 taste Nutrition 0.000 abstract description 4
- 239000003651 drinking water Substances 0.000 abstract description 3
- 235000020188 drinking water Nutrition 0.000 abstract description 3
- 238000010579 first pass effect Methods 0.000 abstract description 2
- 239000002994 raw material Substances 0.000 abstract description 2
- 239000000463 material Substances 0.000 abstract 3
- 235000003599 food sweetener Nutrition 0.000 abstract 2
- 239000003765 sweetening agent Substances 0.000 abstract 2
- 239000011248 coating agent Substances 0.000 abstract 1
- 238000000576 coating method Methods 0.000 abstract 1
- 238000007872 degassing Methods 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 238000001035 drying Methods 0.000 abstract 1
- 239000000796 flavoring agent Substances 0.000 abstract 1
- 235000013355 food flavoring agent Nutrition 0.000 abstract 1
- 238000002156 mixing Methods 0.000 abstract 1
- 238000005303 weighing Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 description 7
- 206010016880 Folate deficiency Diseases 0.000 description 5
- 208000010188 Folic Acid Deficiency Diseases 0.000 description 5
- 208000007502 anemia Diseases 0.000 description 4
- 210000003754 fetus Anatomy 0.000 description 4
- 229940083626 folic acid 0.4 mg Drugs 0.000 description 4
- 238000003556 assay Methods 0.000 description 3
- 235000019658 bitter taste Nutrition 0.000 description 3
- 229940019142 folic acid 5 mg Drugs 0.000 description 3
- 206010002065 Anaemia megaloblastic Diseases 0.000 description 2
- 208000000682 Megaloblastic Anemia Diseases 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 231100001016 megaloblastic anemia Toxicity 0.000 description 2
- 239000013589 supplement Substances 0.000 description 2
- 239000003826 tablet Substances 0.000 description 2
- 208000009206 Abruptio Placentae Diseases 0.000 description 1
- 241000459479 Capsula Species 0.000 description 1
- 208000032170 Congenital Abnormalities Diseases 0.000 description 1
- 206010010356 Congenital anomaly Diseases 0.000 description 1
- 208000019505 Deglutition disease Diseases 0.000 description 1
- 208000001362 Fetal Growth Retardation Diseases 0.000 description 1
- 206010070531 Foetal growth restriction Diseases 0.000 description 1
- 206010070538 Gestational hypertension Diseases 0.000 description 1
- 201000005624 HELLP Syndrome Diseases 0.000 description 1
- 241000282414 Homo sapiens Species 0.000 description 1
- 208000005347 Pregnancy-Induced Hypertension Diseases 0.000 description 1
- 208000006399 Premature Obstetric Labor Diseases 0.000 description 1
- 206010036600 Premature labour Diseases 0.000 description 1
- 201000010829 Spina bifida Diseases 0.000 description 1
- 208000006097 Spinal Dysraphism Diseases 0.000 description 1
- 229930003270 Vitamin B Natural products 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 235000001014 amino acid Nutrition 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 206010002320 anencephaly Diseases 0.000 description 1
- 230000007698 birth defect Effects 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 206010009259 cleft lip Diseases 0.000 description 1
- 208000028831 congenital heart disease Diseases 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 230000001605 fetal effect Effects 0.000 description 1
- 208000030941 fetal growth restriction Diseases 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 229960005150 glycerol Drugs 0.000 description 1
- 208000007475 hemolytic anemia Diseases 0.000 description 1
- 230000036244 malformation Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 201000010193 neural tube defect Diseases 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 230000028742 placenta development Effects 0.000 description 1
- 201000008532 placental abruption Diseases 0.000 description 1
- 208000036335 preeclampsia/eclampsia 1 Diseases 0.000 description 1
- 208000026440 premature labor Diseases 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 235000013772 propylene glycol Nutrition 0.000 description 1
- 230000003161 proteinsynthetic effect Effects 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 208000035581 susceptibility to neural tube defects Diseases 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 235000019156 vitamin B Nutrition 0.000 description 1
- 239000011720 vitamin B Substances 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Embodiment numbering | 6 | 7 | 8 | 9 | 10 |
Mouth feel score (dividing) | 0 | 0 | 0 | 0 | 0 |
(second) dissolved the time limit in oral cavity | 32 | 31 | 33 | 32 | 22 |
Claims (7)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201410378739.6A CN104127370B (en) | 2014-07-31 | 2014-07-31 | A kind of folic acid oral instant membrane and preparation method thereof |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201410378739.6A CN104127370B (en) | 2014-07-31 | 2014-07-31 | A kind of folic acid oral instant membrane and preparation method thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
CN104127370A true CN104127370A (en) | 2014-11-05 |
CN104127370B CN104127370B (en) | 2016-09-14 |
Family
ID=51800396
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CN201410378739.6A Expired - Fee Related CN104127370B (en) | 2014-07-31 | 2014-07-31 | A kind of folic acid oral instant membrane and preparation method thereof |
Country Status (1)
Country | Link |
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CN (1) | CN104127370B (en) |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105982070A (en) * | 2015-02-10 | 2016-10-05 | 苏州百益倍肯新材料科技有限公司 | Melatonin oral cavity instant films and preparation method thereof |
CN105982072A (en) * | 2015-02-10 | 2016-10-05 | 苏州百益倍肯新材料科技有限公司 | Vitamin D3 calcium carbonate oral cavity instant films and preparation method thereof |
CN105982063A (en) * | 2015-02-10 | 2016-10-05 | 苏州百益倍肯新材料科技有限公司 | Mint flavored oral cavity instant films and preparation method thereof |
CN105997949A (en) * | 2016-06-02 | 2016-10-12 | 云南省药物研究所 | Oral dissolving film preparation containing bulleyaconitine A and preparation technology of oral dissolving film preparation |
CN108813630A (en) * | 2018-07-04 | 2018-11-16 | 上海海洋大学 | It is a kind of directly to take orally and instant self-emulsifying film and preparation method thereof |
CN113440499A (en) * | 2021-06-18 | 2021-09-28 | 北京斯利安药业有限公司 | Folic acid oral dissolving film agent and preparation method thereof |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040247744A1 (en) * | 2002-02-11 | 2004-12-09 | Edizone, Lc | Vitamin-containing orally soluble films |
CH696870A5 (en) * | 2004-08-09 | 2008-01-15 | Mepha Ag | Preparing solid oral dosage form containing e.g. vitamin B12 and folic acid, useful to treat e.g. vascular disease, comprises dissolving vitamin B12 and folic acid in binding agent and mixing with other components and auxiliary material |
CN101171037A (en) * | 2005-05-03 | 2008-04-30 | 英诺城有限公司 | Edible film for transmucosal delivery of nutritional supplements |
CN102824333A (en) * | 2012-09-26 | 2012-12-19 | 苏州大学 | Oral quick-dissolving film preparation and preparation method thereof |
CN102836144A (en) * | 2012-09-28 | 2012-12-26 | 天津市聚星康华医药科技有限公司 | Deoxidized epinephrine oral instant film and preparation method thereof |
CN102961365A (en) * | 2012-12-17 | 2013-03-13 | 天津市聚星康华医药科技有限公司 | Terbutaline sulfate oral instant film and preparation method thereof |
CN103263402A (en) * | 2013-05-31 | 2013-08-28 | 天津市聚星康华医药科技有限公司 | Water-drinking-free oral drug composition and preparation method thereof |
-
2014
- 2014-07-31 CN CN201410378739.6A patent/CN104127370B/en not_active Expired - Fee Related
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040247744A1 (en) * | 2002-02-11 | 2004-12-09 | Edizone, Lc | Vitamin-containing orally soluble films |
CH696870A5 (en) * | 2004-08-09 | 2008-01-15 | Mepha Ag | Preparing solid oral dosage form containing e.g. vitamin B12 and folic acid, useful to treat e.g. vascular disease, comprises dissolving vitamin B12 and folic acid in binding agent and mixing with other components and auxiliary material |
CN101171037A (en) * | 2005-05-03 | 2008-04-30 | 英诺城有限公司 | Edible film for transmucosal delivery of nutritional supplements |
CN102824333A (en) * | 2012-09-26 | 2012-12-19 | 苏州大学 | Oral quick-dissolving film preparation and preparation method thereof |
CN102836144A (en) * | 2012-09-28 | 2012-12-26 | 天津市聚星康华医药科技有限公司 | Deoxidized epinephrine oral instant film and preparation method thereof |
CN102961365A (en) * | 2012-12-17 | 2013-03-13 | 天津市聚星康华医药科技有限公司 | Terbutaline sulfate oral instant film and preparation method thereof |
CN103263402A (en) * | 2013-05-31 | 2013-08-28 | 天津市聚星康华医药科技有限公司 | Water-drinking-free oral drug composition and preparation method thereof |
Non-Patent Citations (2)
Title |
---|
ARUN ARYA ET AL.: "Fast Dissolving Oral Films: An Innovative Drug Delivery System and Dosage Form", 《INTERNATIONAL JOURNAL OF CHEMTECH RESEARCH》 * |
M.D. NEHAL SIDDIQUI ET AL.: "A Short Review on "A Novel Approach in Oral Fast Dissolving Drug Delivery System and Their Patents"", 《ADVANCES IN BIOLOGICAL RESEARCH》 * |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105982070A (en) * | 2015-02-10 | 2016-10-05 | 苏州百益倍肯新材料科技有限公司 | Melatonin oral cavity instant films and preparation method thereof |
CN105982072A (en) * | 2015-02-10 | 2016-10-05 | 苏州百益倍肯新材料科技有限公司 | Vitamin D3 calcium carbonate oral cavity instant films and preparation method thereof |
CN105982063A (en) * | 2015-02-10 | 2016-10-05 | 苏州百益倍肯新材料科技有限公司 | Mint flavored oral cavity instant films and preparation method thereof |
CN105997949A (en) * | 2016-06-02 | 2016-10-12 | 云南省药物研究所 | Oral dissolving film preparation containing bulleyaconitine A and preparation technology of oral dissolving film preparation |
CN108813630A (en) * | 2018-07-04 | 2018-11-16 | 上海海洋大学 | It is a kind of directly to take orally and instant self-emulsifying film and preparation method thereof |
CN108813630B (en) * | 2018-07-04 | 2021-09-17 | 上海海洋大学 | Self-emulsifying film agent capable of being directly taken orally and rapidly dissolved and preparation method thereof |
CN113440499A (en) * | 2021-06-18 | 2021-09-28 | 北京斯利安药业有限公司 | Folic acid oral dissolving film agent and preparation method thereof |
Also Published As
Publication number | Publication date |
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CN104127370B (en) | 2016-09-14 |
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Address after: 300384 Haitai Binhai New Area of Tianjin Huayuan Industrial Zone Development six road No. 6 C Haitai green industry base 502 Applicant after: TIANJIN JUXING KANGHUA MEDICAL TECHNOLOGY CO.,LTD. Address before: Three road 300384 Tianjin Haitai Huayuan Industrial Zone No. 1, No. 4, Binhai Branch Building 2 901 Applicant before: TIANJIN JUXING KANGHUA MEDICAL TECHNOLOGY CO.,LTD. |
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