CN104127366B - A kind of camphor tree sesame Chinese medicinal toothpaste and preparation method thereof - Google Patents
A kind of camphor tree sesame Chinese medicinal toothpaste and preparation method thereof Download PDFInfo
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- CN104127366B CN104127366B CN201410373390.7A CN201410373390A CN104127366B CN 104127366 B CN104127366 B CN 104127366B CN 201410373390 A CN201410373390 A CN 201410373390A CN 104127366 B CN104127366 B CN 104127366B
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- China
- Prior art keywords
- camphor tree
- tree sesame
- condensed cream
- toothpaste
- chinese medicinal
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- 241000723346 Cinnamomum camphora Species 0.000 title claims abstract description 59
- 241000207961 Sesamum Species 0.000 title claims abstract description 59
- 235000003434 Sesamum indicum Nutrition 0.000 title claims abstract description 59
- 229940034610 toothpaste Drugs 0.000 title claims abstract description 47
- 239000000606 toothpaste Substances 0.000 title claims abstract description 47
- 238000002360 preparation method Methods 0.000 title claims description 11
- 239000006071 cream Substances 0.000 claims abstract description 53
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 17
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 10
- 235000003599 food sweetener Nutrition 0.000 claims abstract description 9
- 239000003755 preservative agent Substances 0.000 claims abstract description 9
- 230000002335 preservative effect Effects 0.000 claims abstract description 9
- 239000003765 sweetening agent Substances 0.000 claims abstract description 9
- 239000002562 thickening agent Substances 0.000 claims abstract description 9
- 239000004094 surface-active agent Substances 0.000 claims abstract description 8
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 41
- 235000019441 ethanol Nutrition 0.000 claims description 23
- 241001486992 Taiwanofungus camphoratus Species 0.000 claims description 22
- 239000000284 extract Substances 0.000 claims description 21
- 239000006228 supernatant Substances 0.000 claims description 18
- 239000012530 fluid Substances 0.000 claims description 15
- 239000003814 drug Substances 0.000 claims description 11
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 9
- 239000003921 oil Substances 0.000 claims description 9
- 235000019198 oils Nutrition 0.000 claims description 9
- FTLYMKDSHNWQKD-UHFFFAOYSA-N (2,4,5-trichlorophenyl)boronic acid Chemical compound OB(O)C1=CC(Cl)=C(Cl)C=C1Cl FTLYMKDSHNWQKD-UHFFFAOYSA-N 0.000 claims description 8
- 239000000706 filtrate Substances 0.000 claims description 8
- 229940085605 saccharin sodium Drugs 0.000 claims description 8
- 239000001525 mentha piperita l. herb oil Substances 0.000 claims description 7
- 235000019477 peppermint oil Nutrition 0.000 claims description 7
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims description 6
- 238000010992 reflux Methods 0.000 claims description 6
- 239000002202 Polyethylene glycol Substances 0.000 claims description 5
- 229920001223 polyethylene glycol Polymers 0.000 claims description 5
- KSAVQLQVUXSOCR-UHFFFAOYSA-M sodium lauroyl sarcosinate Chemical compound [Na+].CCCCCCCCCCCC(=O)N(C)CC([O-])=O KSAVQLQVUXSOCR-UHFFFAOYSA-M 0.000 claims description 5
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 4
- 235000011187 glycerol Nutrition 0.000 claims description 4
- 239000007788 liquid Substances 0.000 claims description 4
- 239000011734 sodium Substances 0.000 claims description 4
- 229910052708 sodium Inorganic materials 0.000 claims description 4
- 229920001285 xanthan gum Polymers 0.000 claims description 4
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims description 3
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims description 3
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims description 3
- XAAHAAMILDNBPS-UHFFFAOYSA-L calcium hydrogenphosphate dihydrate Chemical compound O.O.[Ca+2].OP([O-])([O-])=O XAAHAAMILDNBPS-UHFFFAOYSA-L 0.000 claims description 3
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims description 3
- ULWHHBHJGPPBCO-UHFFFAOYSA-N propane-1,1-diol Chemical class CCC(O)O ULWHHBHJGPPBCO-UHFFFAOYSA-N 0.000 claims description 3
- 238000000926 separation method Methods 0.000 claims description 3
- 235000011803 sesame oil Nutrition 0.000 claims description 3
- 239000008159 sesame oil Substances 0.000 claims description 3
- 235000019333 sodium laurylsulphate Nutrition 0.000 claims description 3
- 239000007787 solid Substances 0.000 claims description 3
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 2
- 241000282994 Cervidae Species 0.000 claims description 2
- 241000206575 Chondrus crispus Species 0.000 claims description 2
- 241000207199 Citrus Species 0.000 claims description 2
- 235000005979 Citrus limon Nutrition 0.000 claims description 2
- 244000131522 Citrus pyriformis Species 0.000 claims description 2
- 229920002907 Guar gum Polymers 0.000 claims description 2
- 235000019502 Orange oil Nutrition 0.000 claims description 2
- 229930006000 Sucrose Natural products 0.000 claims description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 2
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims description 2
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 claims description 2
- 229910021502 aluminium hydroxide Inorganic materials 0.000 claims description 2
- 239000011575 calcium Substances 0.000 claims description 2
- 229910052791 calcium Inorganic materials 0.000 claims description 2
- JUNWLZAGQLJVLR-UHFFFAOYSA-J calcium diphosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])(=O)OP([O-])([O-])=O JUNWLZAGQLJVLR-UHFFFAOYSA-J 0.000 claims description 2
- 229940043256 calcium pyrophosphate Drugs 0.000 claims description 2
- 239000010630 cinnamon oil Substances 0.000 claims description 2
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- 235000019821 dicalcium diphosphate Nutrition 0.000 claims description 2
- 229960001617 ethyl hydroxybenzoate Drugs 0.000 claims description 2
- NUVBSKCKDOMJSU-UHFFFAOYSA-N ethylparaben Chemical compound CCOC(=O)C1=CC=C(O)C=C1 NUVBSKCKDOMJSU-UHFFFAOYSA-N 0.000 claims description 2
- 239000010643 fennel seed oil Substances 0.000 claims description 2
- 238000000855 fermentation Methods 0.000 claims description 2
- 230000004151 fermentation Effects 0.000 claims description 2
- 238000001914 filtration Methods 0.000 claims description 2
- 239000000665 guar gum Substances 0.000 claims description 2
- 235000010417 guar gum Nutrition 0.000 claims description 2
- 229960002154 guar gum Drugs 0.000 claims description 2
- 235000012907 honey Nutrition 0.000 claims description 2
- 239000001683 mentha spicata herb oil Substances 0.000 claims description 2
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims description 2
- GYCKQBWUSACYIF-UHFFFAOYSA-N o-hydroxybenzoic acid ethyl ester Natural products CCOC(=O)C1=CC=CC=C1O GYCKQBWUSACYIF-UHFFFAOYSA-N 0.000 claims description 2
- 239000010502 orange oil Substances 0.000 claims description 2
- 239000001814 pectin Substances 0.000 claims description 2
- 235000010987 pectin Nutrition 0.000 claims description 2
- 229920001277 pectin Polymers 0.000 claims description 2
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 claims description 2
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 claims description 2
- 229960003415 propylparaben Drugs 0.000 claims description 2
- 229940081974 saccharin Drugs 0.000 claims description 2
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 claims description 2
- 235000019204 saccharin Nutrition 0.000 claims description 2
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 claims description 2
- 239000000377 silicon dioxide Substances 0.000 claims description 2
- 229940048109 sodium methyl cocoyl taurate Drugs 0.000 claims description 2
- 235000019721 spearmint oil Nutrition 0.000 claims description 2
- 239000005720 sucrose Substances 0.000 claims description 2
- 229960004793 sucrose Drugs 0.000 claims description 2
- 235000015112 vegetable and seed oil Nutrition 0.000 claims description 2
- 239000002023 wood Substances 0.000 claims description 2
- 239000000811 xylitol Substances 0.000 claims description 2
- 229960002675 xylitol Drugs 0.000 claims description 2
- 235000010447 xylitol Nutrition 0.000 claims description 2
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims description 2
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 claims 3
- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical group [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 210000004556 brain Anatomy 0.000 claims 1
- 125000005586 carbonic acid group Chemical group 0.000 claims 1
- 239000003906 humectant Substances 0.000 claims 1
- 235000014666 liquid concentrate Nutrition 0.000 claims 1
- 239000004302 potassium sorbate Substances 0.000 claims 1
- 235000010241 potassium sorbate Nutrition 0.000 claims 1
- 229940069338 potassium sorbate Drugs 0.000 claims 1
- 238000000034 method Methods 0.000 abstract description 15
- 230000000694 effects Effects 0.000 abstract description 7
- 230000003266 anti-allergic effect Effects 0.000 abstract description 6
- 230000003110 anti-inflammatory effect Effects 0.000 abstract description 5
- 230000000844 anti-bacterial effect Effects 0.000 abstract description 4
- 230000000840 anti-viral effect Effects 0.000 abstract description 4
- 230000000146 antalgic effect Effects 0.000 abstract description 3
- 239000003845 household chemical Substances 0.000 abstract description 2
- 231100000331 toxic Toxicity 0.000 abstract description 2
- 230000002588 toxic effect Effects 0.000 abstract description 2
- 239000002671 adjuvant Substances 0.000 abstract 1
- 239000002994 raw material Substances 0.000 abstract 1
- 239000008367 deionised water Substances 0.000 description 10
- 229910021641 deionized water Inorganic materials 0.000 description 10
- 238000003756 stirring Methods 0.000 description 10
- 239000000084 colloidal system Substances 0.000 description 7
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical group [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 6
- 238000007872 degassing Methods 0.000 description 6
- 239000000843 powder Substances 0.000 description 6
- 239000008346 aqueous phase Substances 0.000 description 5
- 238000004519 manufacturing process Methods 0.000 description 5
- 239000012071 phase Substances 0.000 description 5
- 208000020670 canker sore Diseases 0.000 description 4
- LRCFXGAMWKDGLA-UHFFFAOYSA-N dioxosilane;hydrate Chemical compound O.O=[Si]=O LRCFXGAMWKDGLA-UHFFFAOYSA-N 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 208000030194 mouth disease Diseases 0.000 description 4
- 229960004029 silicic acid Drugs 0.000 description 4
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 4
- 239000004299 sodium benzoate Substances 0.000 description 4
- 235000010234 sodium benzoate Nutrition 0.000 description 4
- 239000007790 solid phase Substances 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 description 3
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical group [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 3
- 229910000019 calcium carbonate Inorganic materials 0.000 description 3
- 239000001768 carboxy methyl cellulose Substances 0.000 description 3
- 239000012141 concentrate Substances 0.000 description 3
- 229910052731 fluorine Inorganic materials 0.000 description 3
- 239000011737 fluorine Substances 0.000 description 3
- 208000007565 gingivitis Diseases 0.000 description 3
- 239000006210 lotion Substances 0.000 description 3
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 3
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 3
- 206010001497 Agitation Diseases 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 2
- 241000700159 Rattus Species 0.000 description 2
- VEUACKUBDLVUAC-UHFFFAOYSA-N [Na].[Ca] Chemical compound [Na].[Ca] VEUACKUBDLVUAC-UHFFFAOYSA-N 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- 230000000996 additive effect Effects 0.000 description 2
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- 229940084030 carboxymethylcellulose calcium Drugs 0.000 description 2
- 201000002170 dentin sensitivity Diseases 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 239000000686 essence Substances 0.000 description 2
- 238000000227 grinding Methods 0.000 description 2
- 238000010899 nucleation Methods 0.000 description 2
- 230000036347 tooth sensitivity Effects 0.000 description 2
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 description 1
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 description 1
- 241001116389 Aloe Species 0.000 description 1
- 241000205585 Aquilegia canadensis Species 0.000 description 1
- 241001313857 Bletilla striata Species 0.000 description 1
- 208000020084 Bone disease Diseases 0.000 description 1
- 206010006326 Breath odour Diseases 0.000 description 1
- FXALIOUHXMVTMJ-UHFFFAOYSA-N CCCCCCCCCCCC([Na])=O Chemical compound CCCCCCCCCCCC([Na])=O FXALIOUHXMVTMJ-UHFFFAOYSA-N 0.000 description 1
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 208000032139 Halitosis Diseases 0.000 description 1
- 244000024873 Mentha crispa Species 0.000 description 1
- 235000014749 Mentha crispa Nutrition 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 206010067482 No adverse event Diseases 0.000 description 1
- FJAMSRAXXRIOSQ-UHFFFAOYSA-N O.[PH2](=O)O.[PH2](=O)O Chemical compound O.[PH2](=O)O.[PH2](=O)O FJAMSRAXXRIOSQ-UHFFFAOYSA-N 0.000 description 1
- 208000025157 Oral disease Diseases 0.000 description 1
- 241000233855 Orchidaceae Species 0.000 description 1
- 235000019082 Osmanthus Nutrition 0.000 description 1
- 241000333181 Osmanthus Species 0.000 description 1
- 244000131316 Panax pseudoginseng Species 0.000 description 1
- 235000003181 Panax pseudoginseng Nutrition 0.000 description 1
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 1
- 108010077895 Sarcosine Proteins 0.000 description 1
- 240000001949 Taraxacum officinale Species 0.000 description 1
- 235000005187 Taraxacum officinale ssp. officinale Nutrition 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 235000011399 aloe vera Nutrition 0.000 description 1
- 230000001093 anti-cancer Effects 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 210000001772 blood platelet Anatomy 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 description 1
- 229940116229 borneol Drugs 0.000 description 1
- 229960003563 calcium carbonate Drugs 0.000 description 1
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 208000004042 dental fluorosis Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
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- 210000003743 erythrocyte Anatomy 0.000 description 1
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000003682 fluorination reaction Methods 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
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- 125000004435 hydrogen atom Chemical class [H]* 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
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- Cosmetics (AREA)
Abstract
The present invention relates to household chemicals technical field, disclose a kind of camphor tree sesame Chinese medicinal toothpaste.This camphor tree sesame Chinese medicinal toothpaste includes following components count by weight percentage: camphor tree sesame condensed cream is 0.05 3%, rubbing agent 20 50%, NMF 20 30%, surfactant 2 3%, thickener 1 2%, sweetener 0.05 0.25%, preservative 0.05 0.5%, essence 1 2%, and surplus is water.The present invention is as pharmaceutically active raw material using camphor tree sesame, is equipped with the customary adjuvant of toothpaste and common process makes.The camphor tree sesame medicated toothpaste of the present invention has antiallergy, anti-inflammatory and antalgic, the effect such as antibacterial, antiviral, does not has any toxic and side effect to human body.
Description
Technical field
The present invention relates to household chemicals technical field, in particular a kind of camphor tree sesame Chinese medicinal toothpaste and system thereof
Preparation Method.
Background technology
Camphor tree sesame formal name used at school Antrodia cinnamomea, calls Antrodia camphorata, is that the exclusive one of TaiWan, China is rare
Medicinal fungi, has great medical value, is described as " king of medicine ", " anticancer king ", " detoxifies it
King ", " king of anti-inflammatory " etc..Modern study finds, camphor tree sesame contains polysaccharide, triterpenes, steroid and resists
The physiologically active ingredients such as oxidation material, have protect the liver, antitumor, anti-oxidant, reinforced immunological, antiallergy,
Anti-inflammatory, the effect such as antibacterial, antiviral, become the focus of research and development in recent years.
Toothpaste is one of requisite articles for use in people's daily life, can remove the tooth of dental surface with it
Bacterial plaque and swill clean tooth, protection oral hygiene.Toothpaste is generally by rubbing agent, NMF, table
Face activating agent, thickener, sweetener, preservative, essence, pigment, deionized water etc. mix.City
On face, some toothpaste is additionally added some special traditional Chinese medicine ingredients, such as: honeysuckle, pseudo-ginseng, Radix zanthoxyli, SHUANGHUANGLIAN,
The bletilla striata, dandelion, aloe etc., purpose slows down and treats halitosis and canker sore, gingivitis, gum exactly
The mouth disease such as swell and ache.But have not yet to see the tooth for improving oral problem with camphor tree sesame as Chinese medicine additive
Cream.
Summary of the invention
It is an object of the invention to provide a kind of camphor tree sesame Chinese medicinal toothpaste, this toothpaste have antiallergy, anti-inflammatory and antalgic,
The effect such as antibacterial, antiviral, can more effectively prevent and treat mouth disease.
The present invention seeks to be achieved through the following technical solutions: a kind of camphor tree sesame Chinese medicinal toothpaste, percentage by weight
Than calculating, described camphor tree sesame Chinese medicinal toothpaste includes following components: camphor tree sesame condensed cream is 0.05-3%, rubbing agent
20-50%, NMF 20-30%, surfactant 2-3%, thickener 1-2%, sweetener 0.05-0.25%,
Preservative 0.05-0.5%, essence 1-2%, surplus is water.
Further, described camphor tree sesame condensed cream is camphor tree sesame fermented supernatant fluid condensed cream and/or Antrodia camphorata mycelium alcohol extracting
Liquid condensed cream.
Further, described rubbing agent is calcium carbonate, calcium phosphate dibasic dihydrate, calcium pyrophosphate, silica
With at least one in aluminium hydroxide, more preferably hydrated silica, calcium carbonate or calcium phosphate dibasic dihydrate.
Further, during described NMF is glycerine, sorbierite, propane diols, polyethylene glycol and water at least
One, more preferably sorbierite, polyethylene glycol or glycerine.
Further, described surfactant is sodium lauryl sulfate, sodium methyl cocoyl taurate and the moon
At least one in the acylsarcosine sodium of osmanthus, more preferably sodium lauryl sulfate.
Further, described thickener is sodium carboxymethylcellulose, deer horn pectin, hydroxyethyl cellulose, Huang
At least one in virgin rubber, guar gum and carragheen, more preferably sodium carboxymethylcellulose, xanthans or hydroxyl second
Base cellulose.
Further, during described sweetener is saccharin, saccharin sodium, sucrose, xylitol, honey element at least
One, more preferably saccharin sodium.
Further, described preservative be sorbic acid sylvite, Sodium Benzoate, methyl hydroxybenzoate, ethyl hydroxy benzoate and
At least one in Nipasol, more preferably Sodium Benzoate or methyl hydroxybenzoate.
Further, described essence is peppermint oil, lemon sesame oil, spearmint oil, orange oil, citrus seed oil, winter
At least one in wood oil, caryophyllus oil, cinnamon oil, fennel oil and borneol.It is more preferably peppermint oil or stays orchid
Sesame oil.
The present invention also aims to provide the preparation method of this camphor tree sesame Chinese medicinal toothpaste, including:
Step 1: camphor tree sesame condensed cream is provided；
Step 2: described camphor tree sesame condensed cream and other components are mixed and made into toothpaste.
Wherein, in step 1, camphor tree sesame condensed cream includes fermented supernatant fluid condensed cream and/or Antrodia camphorata mycelium alcohol extract
Condensed cream, preferably Antrodia camphorata mycelium alcohol extract condensed cream.
The preparation of fermented supernatant fluid condensed cream: camphor tree sesame passes through deep fermentation, filters after fermenting-ripening, takes
Supernatant concentration prepares fermented supernatant fluid condensed cream.Concentrate the method preferred rotatory vacuum concentration method of cream processed, also
Spray drying process, cool drying method or micro-wave drying method etc. can be used.
The preparation of Antrodia camphorata mycelium alcohol extract condensed cream: take 1 weight portion Antrodia camphorata mycelium；Add 4-8 weight
Amount part absolute ethyl alcohol reflux 1～1.5 hours at 80～90 DEG C, and filtration repeats above step at least twice,
Merge the filtrate of gained；Described filtrate volatilizes at 80～90 DEG C ethanol, and i.e. to obtain Antrodia camphorata mycelium alcohol extract dense
Contracting cream.
Wherein, by permissible with the method that other auxiliary materials are mixed and made into toothpaste for the camphor tree sesame condensed cream that makes in step 2
For multiple, including following three kinds:
One, batch (-type) (two-step method) cream processed:
Step 12: camphor tree sesame condensed cream and thickener are dispersed in NMF, forms solution I；
Step 13: sweetener, preservative are dissolved in deionized water, forms solution II；
Step 14: under strong stirring, solution I and solution II are mixed and inflate it into uniform colloid；
Step 15: colloid stands certain time to be suitably aged, be subsequently adding rubbing agent, surfactant and
Essence is thoroughly mixed in colloid；
Step 16: grinding homogeneous, lotion of toothpaste is made in vacuum outgas；
Two, dry method (one-step method) cream processed
Step 22: NMF, thickener, camphor tree sesame condensed cream, sweetener, preservative, deionized water are thrown
Enter in Manufacturing medicine extract machine, after reaching certain vacuum degree in pot, put into rubbing agent, surfactant, start simultaneously at all
Matter stirs, and degassing limit, limit carries out homogeneous.Homogeneous adds spices after completing, and completes system in homogeneous degassing several minutes
Cream.
Three, wet method (one-step method) cream processed
Step 32: prepare oil phase, aqueous phase, solid phase according to formula.Oil phase: thickener and camphor tree sesame condensed cream
It is mixed in advance in NMF；Aqueous phase: water miscible sweetener, preservative are dissolved in deionized water, then fixed
Amount puts into other remaining NMFs；Solid phase: put in powder material tank after rubbing agent and surfactant are measured；
Step 33: when Manufacturing medicine extract machine vacuum reaches, puts into aqueous phase, oil phase successively, adds powder after stirring homogeneous
Material, as the essence measured after secondary agitation homogeneous, homogeneous several minutes completes cream processed.
Compared with prior art, the beneficial effects of the present invention is: this camphor tree sesame Chinese medicinal toothpaste have antiallergy,
Anti-inflammatory and antalgic, the effect such as antibacterial, antiviral, can effectively prevent and treat hemodia, swelling and aching of gum,
The mouth disease such as bleeding gums, canker sore.The toothpaste of existing market is the most all fluorine-containing, for being sterilized,
Preventing decayed tooth, antiallergy etc..But fluoride is poisonous, the fluorine that concentration is high is very big to harm, the most then shadow
Ring tooth and the growth of bone, fluorination bone disease, den tal fluorosis occur, heavy then Nausea and vomiting, the rhythm of the heart can be caused not
Wait Acute Fluorine together.And the camphor tree sesame Chinese medicinal toothpaste that the present invention provides can not only reach to be sterilized equally, antiallergy
Deng effect, and human body be there is no any toxic and side effect.
Accompanying drawing explanation
Fig. 1 is the use result statistics figure of experimental group in test example 2 of the present invention；
Fig. 2 is the use result statistics figure of control group in test example 2 of the present invention.
Detailed description of the invention
In order to make the technical problem to be solved, technical scheme and beneficial effect clearer,
Below in conjunction with drawings and Examples, the present invention is further elaborated.Should be appreciated that this place is retouched
The specific embodiment stated only in order to explain the present invention, is not intended to limit the present invention.
Embodiment 1 (on the basis of 500g toothpaste)
Take 5g Antrodia camphorata mycelium powder；Add 25g absolute ethyl alcohol, at 80～90 DEG C, reflux 1～1.5 hours,
Filter, repeat above step twice, merge the filtrate of gained；At 80～90 DEG C, volatilize ethanol i.e. obtain camphor tree sesame
Mycelium alcohol extract condensed cream.Take 0.25g Antrodia camphorata mycelium alcohol extract condensed cream, 7.5g carboxymethylcellulose calcium
Sodium and 2.5g xanthans are dispersed in 75g sorbierite and 50g polyethylene glycol.Then by 0.5g saccharin
Sodium and 0.25g Sodium Benzoate are dissolved in appropriate deionized water；Again two kinds of solution are mixed under strong stirring
Conjunction inflates it into uniform colloid.After standing certain time, add 200g hydrated silica, 10g lauroyl
Sodium sarcosinate and 5g peppermint oil, in colloid, stir, and are eventually adding deionized water and are made into 500g.
Grinding homogeneous again, lotion of toothpaste is made in vacuum outgas.
Embodiment 2 (on the basis of 500g toothpaste)
Take 8g Antrodia camphorata mycelium powder；Add 48g absolute ethyl alcohol to reflux at 80～90 DEG C, each 1～1.5
Individual hour, filter, be repeated twice above step, merge the filtrate of gained；Ethanol is volatilized at 80～90 DEG C
Obtain Antrodia camphorata mycelium alcohol extract condensed cream.By 70g sorbierite and 30g glycerine, 10g carboxymethylcellulose calcium
Sodium, 0.4g Antrodia camphorata mycelium alcohol extract condensed cream, 1g saccharin sodium, 0.25g methyl hydroxybenzoate and deionized water are thrown
Enter in Manufacturing medicine extract machine, after reaching certain vacuum degree in pot, put into 100g hydrated silica and 50g calcium carbonate, 10g
Sodium lauroyl sarcosine, starts simultaneously at homogeneous stirring, and degassing limit, limit carries out homogeneous.Homogeneous adds 5g after completing
Peppermint oil, completes cream processed in homogeneous degassing several minutes.
Embodiment 3 (on the basis of 500g toothpaste)
Take 10g Antrodia camphorata mycelium powder；Add 80g absolute ethyl alcohol, reflux at 80～90 DEG C, every time
1～1.5 hours, filter, be repeated twice above step, merge the filtrate of gained；Volatilize at 80～90 DEG C
Ethanol i.e. obtains Antrodia camphorata mycelium alcohol extract condensed cream.By 0.5g Antrodia camphorata mycelium alcohol extract condensed cream and 7.5g
Xanthans is mixed in advance in 50g sorbierite and prepares oil phase；1.25g saccharin sodium and 0.25g methyl hydroxybenzoate are dissolved in
In ionized water, then put into remaining 75g sorbierite and prepare aqueous phase；150g and 100g bis-hypophosphite monohydrate
Hydrogen calcium and 15g sodium lauroyl sarcosine are mixed to prepare solid phase；When Manufacturing medicine extract machine vacuum reaches, put into successively
Aqueous phase, oil phase, add solid phase after stirring homogeneous, adds 10g spearmint essence, homogeneous after secondary agitation homogeneous
Several minutes completes cream processed.
Embodiment 4 (on the basis of 500g toothpaste)
Take the camphor tree sesame bacterium block grown on MEA flat board, prepare through shake-flask seed, seeding tank seed spreads cultivation, send out
After fermenting pot, through separation of solid and liquid, take supernatant and i.e. obtain camphor tree sesame fermented supernatant fluid, use rotatory vacuum concentration method
Concentrate camphor tree sesame fermented supernatant fluid and prepare fermented supernatant fluid contracting cream.By 100g sorbierite and 50g propane diols, 5g
Sodium carboxymethylcellulose and 2.5g hydroxyethyl cellulose, 5g fermented supernatant fluid contracting cream, 1g saccharin sodium, 0.25g
Sodium Benzoate and deionized water put in Manufacturing medicine extract machine, put into 150g and be hydrated silicon after reaching certain vacuum degree in pot
Stone, 10g sodium lauroyl sarcosine, start simultaneously at homogeneous stirring, and degassing limit, limit carries out homogeneous.Homogeneous completes
Rear addition 5g peppermint oil, then homogeneous degassing several minutes complete cream processed.
Embodiment 5 (on the basis of 500g toothpaste)
Take the camphor tree sesame bacterium block grown on MEA flat board, prepare through shake-flask seed, seeding tank seed spreads cultivation, send out
After fermenting pot, through separation of solid and liquid, take supernatant and i.e. obtain camphor tree sesame fermented supernatant fluid, use rotatory vacuum concentration method
Concentrate camphor tree sesame fermented supernatant fluid and prepare fermented supernatant fluid condensed cream.Take 5g Antrodia camphorata mycelium powder；Add 25g
Absolute ethyl alcohol, refluxes at 80～90 DEG C, each 1～1.5 hours, filters, is repeated twice above
Step, merges the filtrate of gained；At 80～90 DEG C, volatilize ethanol i.e. obtain Antrodia camphorata mycelium alcohol extract condensed cream.
Take 0.25g Antrodia camphorata mycelium alcohol extract condensed cream, 10g fermented supernatant fluid condensed cream and 10g carboxymethyl fine
Dimension element sodium is dispersed in 100g sorbierite and 50g polyethylene glycol.Then by 0.5g saccharin sodium and 0.5g
Methyl hydroxybenzoate is dissolved in appropriate deionized water；It is made to expand two kinds of solution mixing again under strong stirring
Uniformly colloid.Stand after certain time, add 180g hydrated silica, 7.5g sodium lauroyl sarcosine and
5g peppermint oil, in colloid, stirs, and is eventually adding deionized water and is made into 500g.Grind homogeneous again,
Lotion of toothpaste is made in vacuum outgas.
Test example 1
The Chinese medicine additive camphor tree sesame this filled a prescription is mixed in mouse grain.Experiment is divided into 3 groups, often group mouse 5.
The addition of camphor tree sesame is followed successively by 20g/kg, 30g/kg, 45g/kg, long-term to small white mouse feeding.During nursing
Observing animal expression and spirit all reacts good, hemalbumin, blood platelet, red blood cell, leukocyte count are the most normal.
Dissect after three months, find that the minority rat of only maximum dose level group has a Minimal change, and rats of other groups
Each organ and tissue is all abnormal or without other pathologies.And the maximum addition of camphor tree sesame is in this formula toothpaste
10g/kg, belongs to safe interpolation scope, it is seen that this prescription toothpaste is safe and reliable, can Long-Time Service.
Test example 2
Research object:
Experimental group: 300 people, suffers from each 50 examples of gingivitis men and women, suffers from each 50 examples of canker sore men and women, suffers from tooth
Each 50 examples of tooth sensitivity men and women, the age is in 25-50 year.
Control group: 300 people, suffers from each 50 examples of gingivitis men and women, suffers from each 50 examples of canker sore men and women, suffers from tooth
Each 50 examples of tooth sensitivity men and women, the age is in 25-50 year.
Using method:
Experimental group: use camphor tree sesame toothpaste；Employing level vibration method is brushed teeth 2 times sooner or later, uses this toothpaste every time
2g；
Control group: use without any drug ingedient and the ordinary toothpaste of special efficacy；Employing level vibration method
Sooner or later brush teeth 2 times, use this toothpaste 2g every time.
Experimental result statistics is as depicted in figs. 1 and 2, it is seen that the odontopathy remission of experimental group is rapid,
Efficient height, and have no adverse reaction.And control group uses the odontopathy remission of ordinary toothpaste very slowly,
And time have recurrence.Therefore, camphor tree sesame Chinese medicinal toothpaste of the present invention can be used for preventing and improve multiple common oral disease
Disease, safely and effectively.
The foregoing is only presently preferred embodiments of the present invention, not in order to limit the present invention, all at this
Any amendment, equivalent and the improvement etc. made within bright spirit and principle, should be included in the present invention
Protection domain within.
Claims (9)
1. a camphor tree sesame Chinese medicinal toothpaste, it is characterised in that count by weight percentage, described camphor tree sesame Chinese medicine
Toothpaste includes following components: camphor tree sesame condensed cream is 0.05-3%, rubbing agent 20-50%, NMF 20-30%,
Surfactant 2-3%, thickener 1-2%, sweetener 0.05-0.25%, preservative 0.05-0.5%, essence
1-2%, surplus is water；
Described camphor tree sesame condensed cream is fermented supernatant fluid condensed cream and Antrodia camphorata mycelium alcohol extract condensed cream, or camphor tree sesame
Mycelium alcohol extract condensed cream.
Camphor tree sesame Chinese medicinal toothpaste the most according to claim 1, it is characterised in that described rubbing agent is carbonic acid
At least one in calcium, calcium phosphate dibasic dihydrate, calcium pyrophosphate, silica and aluminium hydroxide；Described guarantor
Humectant is at least one in glycerine, sorbierite, propane diols, polyethylene glycol and water.
Camphor tree sesame Chinese medicinal toothpaste the most according to claim 1, it is characterised in that described surfactant is
At least one in sodium lauryl sulfate, sodium methyl cocoyl taurate and sodium lauroyl sarcosine.
Camphor tree sesame Chinese medicinal toothpaste the most according to claim 1, it is characterised in that described thickener is carboxylic first
In base sodium cellulosate, deer horn pectin, hydroxyethyl cellulose, xanthans, guar gum and carragheen at least one
Kind.
Camphor tree sesame Chinese medicinal toothpaste the most according to claim 1, it is characterised in that described sweetener be saccharin,
At least one in saccharin sodium, sucrose, xylitol and honey element；Described preservative is potassium sorbate, benzene first
At least one in acid sodium, methyl hydroxybenzoate, ethyl hydroxy benzoate and Nipasol.
Camphor tree sesame Chinese medicinal toothpaste the most according to claim 1, it is characterised in that described essence be peppermint oil,
Lemon sesame oil, spearmint oil, orange oil, citrus seed oil, winter wood oil, caryophyllus oil, cinnamon oil, fennel oil and dragon
At least one in brain.
7., according to the preparation method of the camphor tree sesame Chinese medicinal toothpaste described in claim 1～6 any one, its feature exists
In, comprise the following steps: camphor tree sesame condensed cream is provided；Described camphor tree sesame condensed cream is mixed with other components
Toothpaste.
The preparation method of camphor tree sesame Chinese medicinal toothpaste the most according to claim 7, it is characterised in that described camphor tree
Sesame condensed cream is Antrodia camphorata mycelium alcohol extract condensed cream, and its preparation process is as follows: take 1 weight portion antrodia camphorata mycelium
Body；Add 4-8 weight portion absolute ethyl alcohol at 80～90 DEG C, reflux 1～1.5 hours, filtration, repeats at least
Twice above step, merges the filtrate of gained；Described filtrate is volatilized at 80～90 DEG C ethanol and i.e. obtains camphor tree sesame
Mycelium alcohol extract condensed cream.
The preparation method of camphor tree sesame Chinese medicinal toothpaste the most according to claim 7, it is characterised in that described camphor tree
The preparation process of sesame fermented supernatant fluid condensed cream is as follows: sesame takes after deep fermentation, separation of solid and liquid camphor tree
Clear liquid concentrates and prepares fermented supernatant fluid condensed cream.
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| CN105168012A (en) * | 2015-08-04 | 2015-12-23 | 苏州泽达兴邦医药科技有限公司 | Compound medicinal toothpaste and making method |
| CN107260563A (en) * | 2017-06-30 | 2017-10-20 | 苏州三君日化科技有限公司 | Contain lauroyl alanine sodium salt as the toothpaste of surfactant |
| CN108379137A (en) * | 2017-12-04 | 2018-08-10 | 陈军瑞 | A kind of Kiwi berry toothpaste and preparation method thereof |
| CN108030716A (en) * | 2017-12-04 | 2018-05-15 | 陈军瑞 | A kind of celery toothpaste and preparation method thereof |
| CN107913221A (en) * | 2017-12-04 | 2018-04-17 | 陈军瑞 | A kind of strawberry toothpaste and preparation method thereof |
| CN108056958A (en) * | 2017-12-04 | 2018-05-22 | 陈军瑞 | A kind of tomato toothpaste and preparation method thereof |
| CN107929126A (en) * | 2017-12-04 | 2018-04-20 | 陈军瑞 | A kind of wild jujube toothpaste and preparation method thereof |
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