CN104127366B - A kind of camphor tree sesame Chinese medicinal toothpaste and preparation method thereof - Google Patents
A kind of camphor tree sesame Chinese medicinal toothpaste and preparation method thereof Download PDFInfo
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- CN104127366B CN104127366B CN201410373390.7A CN201410373390A CN104127366B CN 104127366 B CN104127366 B CN 104127366B CN 201410373390 A CN201410373390 A CN 201410373390A CN 104127366 B CN104127366 B CN 104127366B
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Abstract
The present invention relates to household chemicals technical field, disclose a kind of camphor tree sesame Chinese medicinal toothpaste.This camphor tree sesame Chinese medicinal toothpaste includes following components count by weight percentage: camphor tree sesame condensed cream is 0.05 3%, rubbing agent 20 50%, NMF 20 30%, surfactant 2 3%, thickener 1 2%, sweetener 0.05 0.25%, preservative 0.05 0.5%, essence 1 2%, and surplus is water.The present invention is as pharmaceutically active raw material using camphor tree sesame, is equipped with the customary adjuvant of toothpaste and common process makes.The camphor tree sesame medicated toothpaste of the present invention has antiallergy, anti-inflammatory and antalgic, the effect such as antibacterial, antiviral, does not has any toxic and side effect to human body.
Description
Technical field
The present invention relates to household chemicals technical field, in particular a kind of camphor tree sesame Chinese medicinal toothpaste and system thereof
Preparation Method.
Background technology
Camphor tree sesame formal name used at school Antrodia cinnamomea, calls Antrodia camphorata, is that the exclusive one of TaiWan, China is rare
Medicinal fungi, has great medical value, is described as " king of medicine ", " anticancer king ", " detoxifies it
King ", " king of anti-inflammatory " etc..Modern study finds, camphor tree sesame contains polysaccharide, triterpenes, steroid and resists
The physiologically active ingredients such as oxidation material, have protect the liver, antitumor, anti-oxidant, reinforced immunological, antiallergy,
Anti-inflammatory, the effect such as antibacterial, antiviral, become the focus of research and development in recent years.
Toothpaste is one of requisite articles for use in people's daily life, can remove the tooth of dental surface with it
Bacterial plaque and swill clean tooth, protection oral hygiene.Toothpaste is generally by rubbing agent, NMF, table
Face activating agent, thickener, sweetener, preservative, essence, pigment, deionized water etc. mix.City
On face, some toothpaste is additionally added some special traditional Chinese medicine ingredients, such as: honeysuckle, pseudo-ginseng, Radix zanthoxyli, SHUANGHUANGLIAN,
The bletilla striata, dandelion, aloe etc., purpose slows down and treats halitosis and canker sore, gingivitis, gum exactly
The mouth disease such as swell and ache.But have not yet to see the tooth for improving oral problem with camphor tree sesame as Chinese medicine additive
Cream.
Summary of the invention
It is an object of the invention to provide a kind of camphor tree sesame Chinese medicinal toothpaste, this toothpaste have antiallergy, anti-inflammatory and antalgic,
The effect such as antibacterial, antiviral, can more effectively prevent and treat mouth disease.
The present invention seeks to be achieved through the following technical solutions: a kind of camphor tree sesame Chinese medicinal toothpaste, percentage by weight
Than calculating, described camphor tree sesame Chinese medicinal toothpaste includes following components: camphor tree sesame condensed cream is 0.05-3%, rubbing agent
20-50%, NMF 20-30%, surfactant 2-3%, thickener 1-2%, sweetener 0.05-0.25%,
Preservative 0.05-0.5%, essence 1-2%, surplus is water.
Further, described camphor tree sesame condensed cream is camphor tree sesame fermented supernatant fluid condensed cream and/or Antrodia camphorata mycelium alcohol extracting
Liquid condensed cream.
Further, described rubbing agent is calcium carbonate, calcium phosphate dibasic dihydrate, calcium pyrophosphate, silica
With at least one in aluminium hydroxide, more preferably hydrated silica, calcium carbonate or calcium phosphate dibasic dihydrate.
Further, during described NMF is glycerine, sorbierite, propane diols, polyethylene glycol and water at least
One, more preferably sorbierite, polyethylene glycol or glycerine.
Further, described surfactant is sodium lauryl sulfate, sodium methyl cocoyl taurate and the moon
At least one in the acylsarcosine sodium of osmanthus, more preferably sodium lauryl sulfate.
Further, described thickener is sodium carboxymethylcellulose, deer horn pectin, hydroxyethyl cellulose, Huang
At least one in virgin rubber, guar gum and carragheen, more preferably sodium carboxymethylcellulose, xanthans or hydroxyl second
Base cellulose.
Further, during described sweetener is saccharin, saccharin sodium, sucrose, xylitol, honey element at least
One, more preferably saccharin sodium.
Further, described preservative be sorbic acid sylvite, Sodium Benzoate, methyl hydroxybenzoate, ethyl hydroxy benzoate and
At least one in Nipasol, more preferably Sodium Benzoate or methyl hydroxybenzoate.
Further, described essence is peppermint oil, lemon sesame oil, spearmint oil, orange oil, citrus seed oil, winter
At least one in wood oil, caryophyllus oil, cinnamon oil, fennel oil and borneol.It is more preferably peppermint oil or stays orchid
Sesame oil.
The present invention also aims to provide the preparation method of this camphor tree sesame Chinese medicinal toothpaste, including:
Step 1: camphor tree sesame condensed cream is provided；
Step 2: described camphor tree sesame condensed cream and other components are mixed and made into toothpaste.
Wherein, in step 1, camphor tree sesame condensed cream includes fermented supernatant fluid condensed cream and/or Antrodia camphorata mycelium alcohol extract
Condensed cream, preferably Antrodia camphorata mycelium alcohol extract condensed cream.
The preparation of fermented supernatant fluid condensed cream: camphor tree sesame passes through deep fermentation, filters after fermenting-ripening, takes
Supernatant concentration prepares fermented supernatant fluid condensed cream.Concentrate the method preferred rotatory vacuum concentration method of cream processed, also
Spray drying process, cool drying method or micro-wave drying method etc. can be used.
The preparation of Antrodia camphorata mycelium alcohol extract condensed cream: take 1 weight portion Antrodia camphorata mycelium；Add 4-8 weight
Amount part absolute ethyl alcohol reflux 1～1.5 hours at 80～90 DEG C, and filtration repeats above step at least twice,
Merge the filtrate of gained；Described filtrate volatilizes at 80～90 DEG C ethanol, and i.e. to obtain Antrodia camphorata mycelium alcohol extract dense
Contracting cream.
Wherein, by permissible with the method that other auxiliary materials are mixed and made into toothpaste for the camphor tree sesame condensed cream that makes in step 2
For multiple, including following three kinds:
One, batch (-type) (two-step method) cream processed:
Step 12: camphor tree sesame condensed cream and thickener are dispersed in NMF, forms solution I；
Step 13: sweetener, preservative are dissolved in deionized water, forms solution II；
Step 14: under strong stirring, solution I and solution II are mixed and inflate it into uniform colloid；
Step 15: colloid stands certain time to be suitably aged, be subsequently adding rubbing agent, surfactant and
Essence is thoroughly mixed in colloid；
Step 16: grinding homogeneous, lotion of toothpaste is made in vacuum outgas；
Two, dry method (one-step method) cream processed
Step 22: NMF, thickener, camphor tree sesame condensed cream, sweetener, preservative, deionized water are thrown
Enter in Manufacturing medicine extract machine, after reaching certain vacuum degree in pot, put into rubbing agent, surfactant, start simultaneously at all
Matter stirs, and degassing limit, limit carries out homogeneous.Homogeneous adds spices after completing, and completes system in homogeneous degassing several minutes
Cream.
Three, wet method (one-step method) cream processed
Step 32: prepare oil phase, aqueous phase, solid phase according to formula.Oil phase: thickener and camphor tree sesame condensed cream
It is mixed in advance in NMF；Aqueous phase: water miscible sweetener, preservative are dissolved in deionized water, then fixed
Amount puts into other remaining NMFs；Solid phase: put in powder material tank after rubbing agent and surfactant are measured；
Step 33: when Manufacturing medicine extract machine vacuum reaches, puts into aqueous phase, oil phase successively, adds powder after stirring homogeneous
Material, as the essence measured after secondary agitation homogeneous, homogeneous several minutes completes cream processed.
Compared with prior art, the beneficial effects of the present invention is: this camphor tree sesame Chinese medicinal toothpaste have antiallergy,
Anti-inflammatory and antalgic, the effect such as antibacterial, antiviral, can effectively prevent and treat hemodia, swelling and aching of gum,
The mouth disease such as bleeding gums, canker sore.The toothpaste of existing market is the most all fluorine-containing, for being sterilized,
Preventing decayed tooth, antiallergy etc..But fluoride is poisonous, the fluorine that concentration is high is very big to harm, the most then shadow
Ring tooth and the growth of bone, fluorination bone disease, den tal fluorosis occur, heavy then Nausea and vomiting, the rhythm of the heart can be caused not
Wait Acute Fluorine together.And the camphor tree sesame Chinese medicinal toothpaste that the present invention provides can not only reach to be sterilized equally, antiallergy
Deng effect, and human body be there is no any toxic and side effect.
Accompanying drawing explanation
Fig. 1 is the use result statistics figure of experimental group in test example 2 of the present invention；
Fig. 2 is the use result statistics figure of control group in test example 2 of the present invention.
Detailed description of the invention
In order to make the technical problem to be solved, technical scheme and beneficial effect clearer,
Below in conjunction with drawings and Examples, the present invention is further elaborated.Should be appreciated that this place is retouched
The specific embodiment stated only in order to explain the present invention, is not intended to limit the present invention.
Embodiment 1 (on the basis of 500g toothpaste)
Take 5g Antrodia camphorata mycelium powder；Add 25g absolute ethyl alcohol, at 80～90 DEG C, reflux 1～1.5 hours,
Filter, repeat above step twice, merge the filtrate of gained；At 80～90 DEG C, volatilize ethanol i.e. obtain camphor tree sesame
Mycelium alcohol extract condensed cream.Take 0.25g Antrodia camphorata mycelium alcohol extract condensed cream, 7.5g carboxymethylcellulose calcium
Sodium and 2.5g xanthans are dispersed in 75g sorbierite and 50g polyethylene glycol.Then by 0.5g saccharin
Sodium and 0.25g Sodium Benzoate are dissolved in appropriate deionized water；Again two kinds of solution are mixed under strong stirring
Conjunction inflates it into uniform colloid.After standing certain time, add 200g hydrated silica, 10g lauroyl
Sodium sarcosinate and 5g peppermint oil, in colloid, stir, and are eventually adding deionized water and are made into 500g.
Grinding homogeneous again, lotion of toothpaste is made in vacuum outgas.
Embodiment 2 (on the basis of 500g toothpaste)
Take 8g Antrodia camphorata mycelium powder；Add 48g absolute ethyl alcohol to reflux at 80～90 DEG C, each 1～1.5
Individual hour, filter, be repeated twice above step, merge the filtrate of gained；Ethanol is volatilized at 80～90 DEG C
Obtain Antrodia camphorata mycelium alcohol extract condensed cream.By 70g sorbierite and 30g glycerine, 10g carboxymethylcellulose calcium
Sodium, 0.4g Antrodia camphorata mycelium alcohol extract condensed cream, 1g saccharin sodium, 0.25g methyl hydroxybenzoate and deionized water are thrown
Enter in Manufacturing medicine extract machine, after reaching certain vacuum degree in pot, put into 100g hydrated silica and 50g calcium carbonate, 10g
Sodium lauroyl sarcosine, starts simultaneously at homogeneous stirring, and degassing limit, limit carries out homogeneous.Homogeneous adds 5g after completing
Peppermint oil, completes cream processed in homogeneous degassing several minutes.
Embodiment 3 (on the basis of 500g toothpaste)
Take 10g Antrodia camphorata mycelium powder；Add 80g absolute ethyl alcohol, reflux at 80～90 DEG C, every time
1～1.5 hours, filter, be repeated twice above step, merge the filtrate of gained；Volatilize at 80～90 DEG C
Ethanol i.e. obtains Antrodia camphorata mycelium alcohol extract condensed cream.By 0.5g Antrodia camphorata mycelium alcohol extract condensed cream and 7.5g
Xanthans is mixed in advance in 50g sorbierite and prepares oil phase；1.25g saccharin sodium and 0.25g methyl hydroxybenzoate are dissolved in
In ionized water, then put into remaining 75g sorbierite and prepare aqueous phase；150g and 100g bis-hypophosphite monohydrate
Hydrogen calcium and 15g sodium lauroyl sarcosine are mixed to prepare solid phase；When Manufacturing medicine extract machine vacuum reaches, put into successively
Aqueous phase, oil phase, add solid phase after stirring homogeneous, adds 10g spearmint essence, homogeneous after secondary agitation homogeneous
Several minutes completes cream processed.
Embodiment 4 (on the basis of 500g toothpaste)
Take the camphor tree sesame bacterium block grown on MEA flat board, prepare through shake-flask seed, seeding tank seed spreads cultivation, send out
After fermenting pot, through separation of solid and liquid, take supernatant and i.e. obtain camphor tree sesame fermented supernatant fluid, use rotatory vacuum concentration method
Concentrate camphor tree sesame fermented supernatant fluid and prepare fermented supernatant fluid contracting cream.By 100g sorbierite and 50g propane diols, 5g
Sodium carboxymethylcellulose and 2.5g hydroxyethyl cellulose, 5g fermented supernatant fluid contracting cream, 1g saccharin sodium, 0.25g
Sodium Benzoate and deionized water put in Manufacturing medicine extract machine, put into 150g and be hydrated silicon after reaching certain vacuum degree in pot
Stone, 10g sodium lauroyl sarcosine, start simultaneously at homogeneous stirring, and degassing limit, limit carries out homogeneous.Homogeneous completes
Rear addition 5g peppermint oil, then homogeneous degassing several minutes complete cream processed.
Embodiment 5 (on the basis of 500g toothpaste)
Take the camphor tree sesame bacterium block grown on MEA flat board, prepare through shake-flask seed, seeding tank seed spreads cultivation, send out
After fermenting pot, through separation of solid and liquid, take supernatant and i.e. obtain camphor tree sesame fermented supernatant fluid, use rotatory vacuum concentration method
Concentrate camphor tree sesame fermented supernatant fluid and prepare fermented supernatant fluid condensed cream.Take 5g Antrodia camphorata mycelium powder；Add 25g
Absolute ethyl alcohol, refluxes at 80～90 DEG C, each 1～1.5 hours, filters, is repeated twice above
Step, merges the filtrate of gained；At 80～90 DEG C, volatilize ethanol i.e. obtain Antrodia camphorata mycelium alcohol extract condensed cream.
Take 0.25g Antrodia camphorata mycelium alcohol extract condensed cream, 10g fermented supernatant fluid condensed cream and 10g carboxymethyl fine
Dimension element sodium is dispersed in 100g sorbierite and 50g polyethylene glycol.Then by 0.5g saccharin sodium and 0.5g
Methyl hydroxybenzoate is dissolved in appropriate deionized water；It is made to expand two kinds of solution mixing again under strong stirring
Uniformly colloid.Stand after certain time, add 180g hydrated silica, 7.5g sodium lauroyl sarcosine and
5g peppermint oil, in colloid, stirs, and is eventually adding deionized water and is made into 500g.Grind homogeneous again,
Lotion of toothpaste is made in vacuum outgas.
Test example 1
The Chinese medicine additive camphor tree sesame this filled a prescription is mixed in mouse grain.Experiment is divided into 3 groups, often group mouse 5.
The addition of camphor tree sesame is followed successively by 20g/kg, 30g/kg, 45g/kg, long-term to small white mouse feeding.During nursing
Observing animal expression and spirit all reacts good, hemalbumin, blood platelet, red blood cell, leukocyte count are the most normal.
Dissect after three months, find that the minority rat of only maximum dose level group has a Minimal change, and rats of other groups
Each organ and tissue is all abnormal or without other pathologies.And the maximum addition of camphor tree sesame is in this formula toothpaste
10g/kg, belongs to safe interpolation scope, it is seen that this prescription toothpaste is safe and reliable, can Long-Time Service.
Test example 2
Research object:
Experimental group: 300 people, suffers from each 50 examples of gingivitis men and women, suffers from each 50 examples of canker sore men and women, suffers from tooth
Each 50 examples of tooth sensitivity men and women, the age is in 25-50 year.
Control group: 300 people, suffers from each 50 examples of gingivitis men and women, suffers from each 50 examples of canker sore men and women, suffers from tooth
Each 50 examples of tooth sensitivity men and women, the age is in 25-50 year.
Using method:
Experimental group: use camphor tree sesame toothpaste；Employing level vibration method is brushed teeth 2 times sooner or later, uses this toothpaste every time
2g；
Control group: use without any drug ingedient and the ordinary toothpaste of special efficacy；Employing level vibration method
Sooner or later brush teeth 2 times, use this toothpaste 2g every time.
Experimental result statistics is as depicted in figs. 1 and 2, it is seen that the odontopathy remission of experimental group is rapid,
Efficient height, and have no adverse reaction.And control group uses the odontopathy remission of ordinary toothpaste very slowly,
And time have recurrence.Therefore, camphor tree sesame Chinese medicinal toothpaste of the present invention can be used for preventing and improve multiple common oral disease
Disease, safely and effectively.
The foregoing is only presently preferred embodiments of the present invention, not in order to limit the present invention, all at this
Any amendment, equivalent and the improvement etc. made within bright spirit and principle, should be included in the present invention
Protection domain within.
Claims (9)
1. a camphor tree sesame Chinese medicinal toothpaste, it is characterised in that count by weight percentage, described camphor tree sesame Chinese medicine
Toothpaste includes following components: camphor tree sesame condensed cream is 0.05-3%, rubbing agent 20-50%, NMF 20-30%,
Surfactant 2-3%, thickener 1-2%, sweetener 0.05-0.25%, preservative 0.05-0.5%, essence
1-2%, surplus is water；
Described camphor tree sesame condensed cream is fermented supernatant fluid condensed cream and Antrodia camphorata mycelium alcohol extract condensed cream, or camphor tree sesame
Mycelium alcohol extract condensed cream.
Camphor tree sesame Chinese medicinal toothpaste the most according to claim 1, it is characterised in that described rubbing agent is carbonic acid
At least one in calcium, calcium phosphate dibasic dihydrate, calcium pyrophosphate, silica and aluminium hydroxide；Described guarantor
Humectant is at least one in glycerine, sorbierite, propane diols, polyethylene glycol and water.
Camphor tree sesame Chinese medicinal toothpaste the most according to claim 1, it is characterised in that described surfactant is
At least one in sodium lauryl sulfate, sodium methyl cocoyl taurate and sodium lauroyl sarcosine.
Camphor tree sesame Chinese medicinal toothpaste the most according to claim 1, it is characterised in that described thickener is carboxylic first
In base sodium cellulosate, deer horn pectin, hydroxyethyl cellulose, xanthans, guar gum and carragheen at least one
Kind.
Camphor tree sesame Chinese medicinal toothpaste the most according to claim 1, it is characterised in that described sweetener be saccharin,
At least one in saccharin sodium, sucrose, xylitol and honey element；Described preservative is potassium sorbate, benzene first
At least one in acid sodium, methyl hydroxybenzoate, ethyl hydroxy benzoate and Nipasol.
Camphor tree sesame Chinese medicinal toothpaste the most according to claim 1, it is characterised in that described essence be peppermint oil,
Lemon sesame oil, spearmint oil, orange oil, citrus seed oil, winter wood oil, caryophyllus oil, cinnamon oil, fennel oil and dragon
At least one in brain.
7., according to the preparation method of the camphor tree sesame Chinese medicinal toothpaste described in claim 1～6 any one, its feature exists
In, comprise the following steps: camphor tree sesame condensed cream is provided；Described camphor tree sesame condensed cream is mixed with other components
Toothpaste.
The preparation method of camphor tree sesame Chinese medicinal toothpaste the most according to claim 7, it is characterised in that described camphor tree
Sesame condensed cream is Antrodia camphorata mycelium alcohol extract condensed cream, and its preparation process is as follows: take 1 weight portion antrodia camphorata mycelium
Body；Add 4-8 weight portion absolute ethyl alcohol at 80～90 DEG C, reflux 1～1.5 hours, filtration, repeats at least
Twice above step, merges the filtrate of gained；Described filtrate is volatilized at 80～90 DEG C ethanol and i.e. obtains camphor tree sesame
Mycelium alcohol extract condensed cream.
The preparation method of camphor tree sesame Chinese medicinal toothpaste the most according to claim 7, it is characterised in that described camphor tree
The preparation process of sesame fermented supernatant fluid condensed cream is as follows: sesame takes after deep fermentation, separation of solid and liquid camphor tree
Clear liquid concentrates and prepares fermented supernatant fluid condensed cream.
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| WO2016015283A1 (en) * | 2014-07-31 | 2016-02-04 | 深圳市仁泰生物科技有限公司 | Antrodia cinnamomea chinese herbal toothpaste and preparation method therefor |
| CN105168012A (en) * | 2015-08-04 | 2015-12-23 | 苏州泽达兴邦医药科技有限公司 | Compound medicinal toothpaste and making method |
| CN107260563A (en) * | 2017-06-30 | 2017-10-20 | 苏州三君日化科技有限公司 | Contain lauroyl alanine sodium salt as the toothpaste of surfactant |
| CN107913221A (en) * | 2017-12-04 | 2018-04-17 | 陈军瑞 | A kind of strawberry toothpaste and preparation method thereof |
| CN108030716A (en) * | 2017-12-04 | 2018-05-15 | 陈军瑞 | A kind of celery toothpaste and preparation method thereof |
| CN108056958A (en) * | 2017-12-04 | 2018-05-22 | 陈军瑞 | A kind of tomato toothpaste and preparation method thereof |
| CN108379137A (en) * | 2017-12-04 | 2018-08-10 | 陈军瑞 | A kind of Kiwi berry toothpaste and preparation method thereof |
| CN107929126A (en) * | 2017-12-04 | 2018-04-20 | 陈军瑞 | A kind of wild jujube toothpaste and preparation method thereof |
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| CN103789358A (en) * | 2014-01-28 | 2014-05-14 | 上海市农业科学院 | Method for preparing 2-phenethyl alcohol by adopting antrodia cinnamomea submerged fermentation technology |
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| CN103789358A (en) * | 2014-01-28 | 2014-05-14 | 上海市农业科学院 | Method for preparing 2-phenethyl alcohol by adopting antrodia cinnamomea submerged fermentation technology |
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