CN104127233B - It is a kind of for adjust nerve device - Google Patents
It is a kind of for adjust nerve device Download PDFInfo
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- CN104127233B CN104127233B CN201310161218.0A CN201310161218A CN104127233B CN 104127233 B CN104127233 B CN 104127233B CN 201310161218 A CN201310161218 A CN 201310161218A CN 104127233 B CN104127233 B CN 104127233B
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Abstract
The present invention provides a kind of for adjusting the device of nerve, including the adjusting component for adjusting the nerve, the component that adjusts includes for will adjust energy transmission to one or more electrodes of the nerve and the electrode load bearing component for being used to carry the electrode, the electrode load bearing component has first shape and the second shape, the adjusting component is suitble to move in the blood vessel under the first shape, and described at least one electrode for adjusting component, which is in, under second shape is suitble to the adjusting energy transmission to the position of the nerve；Described device further includes the control assembly for the adjusting component to be transported to the position close to the nerve and convert the electrode load bearing component between first shape and the second shape.Device provided by the present invention for adjusting nerve operates conveniently, and multiple neural sites can be adjusted simultaneously, to improve working efficiency.
Description
Technical field
The present invention relates to electrosurgery more particularly to it is a kind of for adjust nerve device.
Background technique
Resistant hypertension, i.e., height still uncontrollable using 3 kinds or more drugs (all having used a diuretics)
Blood pressure (sBP >=160mmHg), clinically more typically, pathogenic factor is numerous, and pathogenesis is indefinite, medication effect
Very poor, diagnosing and treating technology is still not mature enough, becomes one of great difficult problem of hypertension therapeutic.
Newest animal and clinical laboratory data proof can significantly hold the adjusting (such as removing sympathetic nerve) of renal nerve
Lower resistant hypertension, such as the renal artery radiofrequency ablation art that latest developments go out long.Renal artery radiofrequency ablation art is a kind of
By the way that electrode catheter intravascular is sent into privileged site in the arteria renalis, release radio-frequency current causes arteria renalis sympathetic nerve locally solidifying
Solidity necrosis, reaches denervated interventional techniques.Radio-frequency current damage range is small, not will cause body harm, therefore kidney is dynamic
A kind of method that arteries and veins radio-frequency ablation procedure has become effective removal arteria renalis sympathetic nerve.
In addition, being proved to have certain effect to a variety of diseases relevant to kidney to the adjusting of renal nerve, especially kidney is handed over
Feel related disease caused by neural overactivity.For example, congestive heart failure (CHF) can lead to abnormal high renal sympathetic mind
It is activated, so as to cause the reduction of the water and sodium removed from body, and increase the secretion of feritin.Increased renin secretion leads to kidney
Vessel retraction causes the reduction of renal blood flow.To which kidney can make the reaction of heart failure the spiral of heart failure condition
Decline extends.
It is existing at present although having been reported that the related equipment for adjusting arteria renalis sympathetic nerve in pertinent literature or patent
Instrument the defects of having inconvenient, cost of manufacture high or inefficiency.
In consideration of it, the present invention provides a kind of new device for being used to adjust nerve.
Summary of the invention
The object of the present invention is to provide a kind of devices for being used to adjust nerve and treating related disease operated conveniently.
The device provided by the present invention for being used to adjust nerve, it is described including the adjusting component for adjusting the nerve
Adjusting component includes for will adjust energy transmission to one or more electrodes of the nerve and be used to carry the electrode
Electrode load bearing component, which is characterized in that the electrode load bearing component have first shape and the second shape, in first shape
The adjusting component is suitble to move in the blood vessel under shape, under second shape at described at least one electrode for adjusting component
In suitable by the adjusting energy transmission to the position of the nerve；Described device further includes for conveying the adjusting component
To the position close to the nerve and the control group that converts the electrode load bearing component between first shape and the second shape
Part.
Preferably, the nerve is the renal nerve on people's arteria renalis, " close to the position of the nerve "
It refers to being located in the arteria renalis.
Preferably, the adjusting refers to the activation for removing or reducing the nerve by damage or non-damaging mode.
Preferably, the energy is a kind of or several in heat, cooling, electromagnetic energy, radio frequency, ultrasonic wave, microwave or luminous energy
Kind.
Preferably, the blood vessel is people's arteria renalis.
Preferably, " being suitble to move in the blood vessel " refers to when the adjusting component moves in the blood vessel, institute
It states adjusting component and does not damage vascular wall.
Preferably, described " being suitble to move in the blood vessel " refer to the adjusting component the blood vessel radially
Full-size is not more than the internal diameter of the blood vessel.
Preferably, described " being suitble to move in the blood vessel " refer to the adjusting component the blood vessel radially
Full-size is not more than 4mm.
Preferably, " being suitble to the adjusting energy transmission to the position of the renal nerve " refers to when the tune
When saving component in the blood vessel, at least one electrode is in the position of contact vascular wall.
Preferably, " being suitble to the adjusting energy transmission to the position of the renal nerve " refers to the adjusting
Component is 4-8mm in the full-size radially of the blood vessel, at least one electrode is at full-size.
Preferably, the adjusting component includes multiple electrodes, the multiple electricity for adjusting component under second shape
Pole is all in suitable by the adjusting energy transmission to the position of the nerve.
Preferably, the electrode load bearing component is internally provided with for connecting said electrodes to energy generation apparatus
Conducting wire.
Preferably, the electrode is cyclic annular or tubulose, is socketed on the outside of the electrode load bearing component.
Preferably, second shape is own form of the electrode load bearing component under not by external force.
Preferably, the distal end of the electrode load bearing component or proximate distal ends be provided under X-ray show electrode carry
The flag member of component locations.
Preferably, the distal end of the electrode load bearing component is provided with the protection portion for vascular damaged to be reduced or avoided
Part.It is highly preferred that the material of the guard block is softer than the material of electrode load bearing component.
Preferably, the first shape of the electrode load bearing component is one kind of elongate, bar shaped, filiform or threadiness.
Preferably, the second shape of the electrode load bearing component is spiral shape.It is highly preferred that the spiral diameter is
4-8mm。
Preferably, the number of the electrode is 2-6, adjacent when the electrode load bearing component is in the second shape
Distance of the electrode in the axial direction of the blood vessel is 4-6mm.It is highly preferred that the number of the electrode is 4.
Preferably, the control assembly includes for being transported to the adjusting component close to the defeated of the position of the nerve
Component is sent, the shape of the transfer unit is one kind of elongate, bar shaped, filiform or threadiness, the distal end of the transfer unit
It is connected with the proximal end of the electrode load bearing component.It is furthermore preferred that the material phase of the transfer unit and the electrode load bearing component
Together and it is linked together.In addition, the transfer unit, which preferably has, to be transported to people's kidney from human radial artery for the adjusting component
The length of artery.It is furthermore preferred that the length of the transfer unit is 130cm-160cm.
Preferably, the control assembly includes for making the electrode load bearing component between first shape and the second shape
The shape control unit part of transformation.
Preferably, the inside of the electrode load bearing component and the transfer unit has for accommodating the shape control unit
The shape control channel of part, the shape control unit part are located in the shape control channel of the transfer unit, and the electrode is held
It carries component and the shape control unit part is configured to the shape for utilizing the shape control unit part in the electrode load bearing component
The disengaging of control channel and change the electrode load bearing component between first shape and the second shape.It is highly preferred that affiliated
Control assembly includes the handle held for user, and the transfer unit is installed on the handle, and the handle, which has, to be accommodated
The shape control channel of the shape control unit part, the shape control unit part are extended through the shape control channel of the handle
To the outside of the handle.
Preferably, the shape control unit part is coated at the transfer unit and can slide along the transfer unit, described
Electrode load bearing component and the shape control unit part are configured: when the shape control unit part is coated at the electrode load bearing component
When with electrode, the electrode load bearing component is in first shape, when the shape control unit part is detached from the electrode load bearing component
When with electrode, the electrode load bearing component is in the second shape.It is highly preferred that the control assembly includes holding for user
Handle, the transfer unit is installed on the handle.Alternatively, the distal end of the shape control unit part or proximate distal ends setting are used
In the flag member for showing shape control unit part position under X-ray.
Device provided by the present invention for adjusting nerve operates conveniently, and can simultaneously to multiple neural sites into
Row is adjusted, to improve working efficiency.
It is described further below with reference to technical effect of the attached drawing to design of the invention, specific structure and generation, with
It is fully understood from the purpose of the present invention, feature and effect.
Detailed description of the invention
Fig. 1 is the structural schematic diagram of people's kidney and linked groups.
Fig. 2 is the structural schematic diagram of people's arteria renalis.
Fig. 3 is the component part signal provided by the present invention for a kind of specific embodiment for adjusting the device of nerve
Figure, the figure shows the first shapes of electrode load bearing component.
Fig. 4 is shown in Fig. 3 for adjusting the schematic diagram of another state of the device of nerve, and the figure shows electrodes to hold
Carry the second shape of component.
Fig. 5 is shown in Fig. 3 for adjusting the structural schematic diagram of the device of nerve.
Fig. 6 is the structural schematic diagram provided by the present invention for another specific embodiment for adjusting the device of nerve.
Specific embodiment
Below with the drawings and specific embodiments, the present invention will be further described.For ease of description, in the present invention
One end of the close user (or handle) or the separate neural site for needing to adjust of device or component are known as " proximal end ", will be filled
It sets or the separate user (or handle) of component or is known as " distal end " close to the one end in neural site for needing to adjust.
Fig. 1-Fig. 5 shows the device provided by the present invention for adjusting nerve and its one kind of application method is preferred
Specific embodiment.The specific embodiment is by taking the device for adjusting people's renal nerve as an example.
Fig. 2 shows the linked groups of people's kidney and structures by Fig. 1-.As shown in Figure 1, Ren Shen linked groups anatomically wrap
Kidney K is included, kidney K is supplied to oxygen containing blood by arteria renalis RA.Arteria renalis RA is connected to heart via the aortic artery AA of abdomen.It is de-
The blood of oxygen flows to heart from kidney via renal vein RV and inferior caval vein IVC.Fig. 2 illustrates anatomical one, kidney in more detail
Point.More specifically, kidney anatomy also includes the renal nerve RN longitudinally extended along the axial L of arteria renalis RA.Renal nerve RN mono-
As in the outer membrane of the artery.In this specific embodiment, provided device is located on arteria renalis RA for adjusting
Renal nerve RN, the adjusting refer to the activation for removing or reducing renal nerve RN by damage or non-damaging mode.As this
The variation of specific embodiment adjusts the nerve (for example, heart related neural) at other positions if necessary, or needs other
The regulative mode activation of nerve (for example, it is desired to further improve), those skilled in the art can make according to the present invention
Can rational expectation, do not need the adjustment for being put to creative work.
Fig. 3 and Fig. 4 shows the component part of the device for adjusting nerve in the specific embodiment.Such as Fig. 3 and
Shown in Fig. 4, which includes adjusting component 100 first；Adjusting component 100 includes electrode 101 and electrode load bearing component 102.When
When electrode is close to the neural site for needing to adjust, electrode discharges certain energy and acts on the nerve site, to play tune
Save the effect in the nerve site (for example, the activation for reducing or eliminating sympathetic nerve).
Electrode can realize the purpose and transferring heat to the nerve site.For example, being used for the biography of nerve modulation
Hot heating mechanism may include heating ablation and the thermal change of non-ablation or damage, for example, the temperature of target nerve fibre can be increased
The thermal change for realizing non-ablation is moved more than required threshold value, or the thermal change of ablation is realized more than higher temperature.For example, target temperature can
With about 37 DEG C -45 DEG C (the thermal change temperature for non-thermal ablation), alternatively, the target temperature can at about 45 DEG C or more
Height, with the thermal change for ablation.
Electrode can also be transmitted to the nerve site and realize the purpose by that will cool down.For example, by target nerve fibre
Temperature is reduced to about 20 DEG C or less and is reduced to about 0 DEG C or less to realize non-frozen thermal change, or by the temperature of target nerve fibre
To realize the thermal change of freezing.
Electrode can also be realized by the way that energy field is applied to target nerve fibre.The energy field may include: electromagnetic energy,
Radio frequency, ultrasonic wave (including high-intensity focusing ultrasonic wave), microwave, luminous energy (including laser, infrared ray and near infrared ray) etc..Example
Such as, the nerve modulation of thermal induction can be realized and pulse or continuous thermal energy field is delivered to target nerve fibre.Wherein,
A kind of than more preferably energy mode is pulse radiation frequency electric field or other types of pulse heat energy.Pulse radiation frequency electric field or other classes
The pulse heat energy of type can facilitate bigger heat level, longer total duration and/or preferably controlled intravascular renal
Nerve modulation treatment.
No matter realized by which kind of energy mode and adjust neural purpose, when user uses device provided by the present invention
When being worked, electrode needs to carry out electricity with the equipment for generating the energy (such as radiofrequency generator) or making electrode itself and generating the energy
Connection.The connection of these equipment and electrode and these equipment be the prior art well-known to those skilled in the art (for example,
Interface for connecting these equipment is set in apparatus of the present invention, and when use can realize plug and play), it no longer chats in detail here
It states.
In this embodiment, electrode 101 is close to the mode in renal nerve site for needing to adjust are as follows: via blood vessel into
Enter human body, by arteria renalis inner wall close to neural site.Therefore, work is being carried out using device provided by the specific embodiment
When making, a technical issues that need to address are: should realize that electrode can be close to internal blood vessel to act on corresponding position
Nerve, and need electrode that can easily move in the blood vessel, and do not damage vascular wall.The specific embodiment is using as follows
Technical solution solves this technical problem: configuration electrode load bearing component 102 is with first shape (as shown in Figure 3) and second
Shape (as shown in Figure 4).As shown in figure 3, first shape is straight or close to straight bar shaped (or elongate or threadiness or silk
Shape), the cross section of the bar shaped is preferably circular or approximate circle, and the widest part of cross section is less than the interior diameter of blood vessel.In this way,
Under first shape, when adjusting component 100 moves in the blood vessel, vascular wall will not be damaged by adjusting component 100.It is dynamic to kidney when needing
When nerve on arteries and veins is adjusted, since the interior diameter of people's arteria renalis is generally 4-7mm, component 100 is adjusted in the arteria renalis
Full-size radially be not more than 4mm, it is preferably provided as 1-2mm, not only can satisfy and are moved easily in the blood vessels, but also have
Enough rigidity and convenient for production, and can reduce the size of the wound of patient.As the variation of the specific embodiment,
One shape also can permit certain bending or wavy bending, and cross section may be other shapes, as long as its table
Face is smooth, can easily move in the blood vessels without damaging vascular wall.
Under the second shape of electrode load bearing component, the electrode for adjusting component 100, which is in, to be suitble to arrive adjusting energy transmission
The position of renal nerve.As shown in figure 4, in this specific embodiment, the second shape generally spiral of electrode load bearing component 102
Shape.When electrode 102 generally spiral shape of load bearing component, in blood vessel radially (perpendicular to the axial direction of blood vessel), component is adjusted
100 the widest part is bigger than first shape, and the electrode that can be allowed to carry in this way comes close to or in contact with vascular wall, thus close to kidney mind
Through.By groping, it is contemplated that blood vessel has certain elasticity, and the diameter of spiral is set as 4-8mm than convenient.For example, being directed to
The lesser individual of arteria renalis internal diameter (such as internal diameter is 4mm or so), can set 5mm or so for the diameter of spiral；For kidney
The biggish individual of Diameter (such as internal diameter is 7mm or so), can set 8mm or so for the diameter of spiral.As the tool
The variation of body embodiment, the second shape may be other shapes, for example, having round and smooth curved irregular shape, only
If when the electrode load bearing component in the blood vessel when, electrode be in contact vascular wall position.
In this specific embodiment, electrode 101 is ring-type, and is socketed in the outer surface of electrode load bearing component 102.This
Sample, when electrode load bearing component 102 is spiral shape (in the arteria renalis), the electrode 101 on electrode load bearing component 102 is in contact
The position (close to renal nerve) of arteria renalis inner wall, can be adjusted work in this way.In order to be firmly installed in electrode 101
It on electrode load bearing component 102, and reduces the damage to vascular wall to the greatest extent, can be arranged in the outer surface of electrode load bearing component 102
Shape and the matched ring-shaped depression of electrode 101, are fixed on corresponding position for electrode 101.In addition, the outer surface of electrode 101 with
The outer surface in the region of adjacent electrode load bearing component 102 forms the curved surface of relative smooth, to reduce the damage to vascular wall.Make
For the variation of the specific embodiment, electrode 101 can also be mounted on otherwise on electrode load bearing component 102, for example,
Electrode 101 is bulk, is embedded in the outer surface of electrode load bearing component 102.In addition, electrode load bearing component 102 is internally provided with use
In the conducting wire (not shown) that electrode 101 is connected to energy generation apparatus (such as radiofrequency generator), when with multiple electrodes,
Need to be arranged the more conducting wires that multiple electrodes are connected to energy generation apparatus respectively.It can also be set on electrode load bearing component 102
Set element (for example, thermocouple) and the corresponding conducting wire for measuring temperature, conducting wire and thermocouple are arranged as this field
Conventional arrangement, I will not elaborate.
In this specific embodiment, the number of electrode 101 is four.When electrode load bearing component 102 is in the second shape
When (helical form), distance D of the adjacent electrode in the axial direction of blood vessel is 4-6mm than convenient.It is, in general, that carrying out renal nerve
When ablative surgery, 5-8 site of renal nerve is melted.Therefore, work is carried out using the device in the specific embodiment
When making, the ablation in positioning (electrode is made to contact blood vessel) achievable four sites of Primary regulation component, and complete entirely to disappear
Melt the positioning that operation only needs to carry out adjusting component twice.As the variation of the specific embodiment, the number of electrode
It can be set to 2-6, but if number is more, will increase the cost of manufacture of whole device；If number is less, it can reduce and disappear
Melt the working efficiency of operation.The preferable or more stable metal or metal alloy of biocompatibility, example can be used in the material of electrode
Such as platinum group metal (such as platinumiridio).
In this specific embodiment, the distal end of electrode load bearing component 102 is additionally provided with flag member 103 and guard block
104.The effect of flag member 103 is the show electrode load bearing component position under X-ray, and it is preferable that biocompatibility can be selected in material
Or more stable metal or metal alloy, such as platinum group metal (such as platinumiridio).Flag member 103 or ring-type,
It is socketed in the outer surface of the distal end of electrode load bearing component 102.The effect of guard block 104 is that vascular damaged is reduced or avoided,
Guard block 104 can it is relatively soft for one section of material (such as the high molecule plastic that material is relatively soft, as Pebax2533,
Pebax3533, TPU etc.) object, be connected to the distal end of electrode load bearing component 102, avoid the distal end of electrode load bearing component 102
Damage blood vessel.
Device in the specific embodiment further includes control assembly 200, and control assembly 200 includes for that will adjust component
100 are transported to the transfer unit 201 of the position (being transported in the arteria renalis) of close renal nerve and electrode load bearing component 102 are made to exist
The shape control unit part 202(converted between first shape and the second shape is as shown in Figure 3 and Figure 4).Fig. 5 shows transfer unit
201 and shape control unit part 202 structure.As shown in figure 5, the distal end of transfer unit 201 and the proximal end of electrode load bearing component 102
It is connected, if they use same material, can also be integrally formed.The shape of transfer unit 201 be bar shaped (or elongate or
Threadiness is Filamentous), there is the rigidity and flexible for being suitble to move in the blood vessel, length can according to need setting.Example
Such as, if user, which needs, can configure transfer unit by being transported in the arteria renalis through will adjust component 100 at femoral artery
201 length is most appropriate in 80cm to 130cm(105cm or so)；If user needs by that will adjust at trans-radial
Component 100 is transported in the arteria renalis, and the length that can configure transfer unit 201 is the most suitable in 130cm to 160cm(155cm or so
Preferably).The cross section of transfer unit 201 is preferably circular, and diameter is not more than the internal diameter for needing the blood vessel passed through, and diameter is excellent
It is selected as 1-2mm or so, not only can satisfy and be moved easily in the blood vessels, but also there is enough rigidity and convenient for production, and can be with
Reduce the size of the wound of patient.
In this specific embodiment, electrode load bearing component 102 and transfer unit 201 are internally provided with for accommodating shape
The shape control channel of control unit 202, the shape of shape control unit part 202 are bar shaped (or elongate or threadiness or silk
Shape), it close to remote position is straight or close to straight bar shaped, entire shape of the shape control unit part 202 through transfer unit 201
Shape control channel and the proximal end for extending beyond transfer unit 201.In addition, the second shape of electrode load bearing component 102 is held for electrode
Own form of the component not by external force when is carried, and electrode load bearing component 102 is made using Elastic memory material.?
That is generally spiral shape in the case where not by external force of electrode load bearing component 102.The specific embodiment is using such as
Lower technical solution coordination electrode load bearing component 102 changes between first shape and the second shape: shape control unit part 202 uses
The material harder than the material of electrode load bearing component is made, for example, the material of electrode load bearing component 102 be high molecule plastic (such as
Pebax3533, Pebax4033, TPU etc.), high molecule plastic inside or inner wall setting Elastic memory material titanium-nickel wire (guarantee electricity
Pole load bearing component 102 be not restored to the second shape by the case where external force), the material of shape control unit part 202 is stainless
Steel；In this way, the proximal end (outside for being exposed at transfer unit 201) that user can pinch shape control unit part 202 pushes
With the operation retracted so that the shape control channel of the into and out electrode load bearing component 102 of shape control unit part 202；Work as shape
When shape control unit 202 enters the shape control channel of electrode load bearing component 102, due to the material of shape control unit part 202
Hardness is bigger than electrode load bearing component 102, and shape control unit part 202 can show first shape (straight or close to straight bar shaped)；
When shape control unit part 202 is detached from the shape control channel of electrode load bearing component 102, due to electrode load bearing component 102 itself
Elastic acting force, electrode load bearing component 102 is restored to the second shape (helical form)；Electrode load bearing component 102 is realized therefrom
Change between first shape and the second shape.
In addition, in this specific embodiment, in order to which user holds conveniently, control assembly 200 further includes being suitable for using
The handle 203 that person holds, transfer unit 201 are installed on handle 203, also have in handle 203 and accommodate shape control unit part 202
Shape control channel, shape control unit part 202 are extended to the outside of handle 203 by the shape control channel of handle 203, are used for
User pushes and pulls back the operation of shape control unit part 202.
When the inside of electrode load bearing component 102 and transfer unit 201 needs while accommodating shape control unit part 202 and Duo Gen
Conducting wire (it is as stated above, when carrying multiple electrodes on electrode load bearing component 102, and being additionally provided with the elements such as thermocouple,
Need that electrode and these elements are connected to corresponding equipment respectively with multiple conducting wires) when, one kind is preferably in electrode
The two or more mutually independent channels of setting in load bearing component 102 and transfer unit 201, shape control unit part 202 use
One of autonomous channel, conducting wire is using other one or more channels (as long as conducting wire can insulate i.e. between each other
Can).
The foregoing describe a kind of specific embodiments of shape control unit part 202.As the variation of the specific embodiment,
Shape control unit part 202 can also be realized by another way electrode load bearing component 102 first shape and the second shape it
Between change.As shown in fig. 6, shape control unit part 202 is the tube body of bar shaped (or elongate or threadiness or filiform), close to distal end
Part be straight or close to straight bar shaped tube body, be coated at the outside of transfer unit 201 and can be slided along transfer unit 201.
Shape control unit part 202 is made of the material harder than the material of electrode load bearing component 102, for example, electrode load bearing component 102
Material is relatively soft high molecule plastic (such as Pebax3533, Pebax4033, TPU), the material of shape control unit part 202
For relatively hard high molecule plastic (such as ABS, PC)；In this way, user can griping shape control unit 202 proximal end
The operation for being pushed and being retracted, so that shape control unit part 202 is coated at electrode load bearing component 102 and is detached from electrode supporting part
Part 102；When shape control unit part 202 is coated at electrode load bearing component 102, due to shape control unit part 202 material it is hard
Degree is bigger than electrode load bearing component 102, and shape control unit part 202 can show first shape (straight or close to straight bar shaped)；When
When shape control unit part 202 is detached from electrode load bearing component 102, due to the elastic acting force of electrode load bearing component 102 itself, electrode
Load bearing component 102 is restored to the second shape (helical form)；Realize electrode load bearing component 102 in first shape and the second shape therefrom
Change between shape.In addition, the distal end of shape control unit part 202 or proximate distal ends may be provided for showing shape under X-ray
The flag member of 202 position of control unit, in case shape control unit part 202 stretches out electrode load bearing component too much at the time of surgery,
Except 102, to damage nephridial tissue.
The foregoing describe the specific embodiments of the device provided by the present invention for adjusting nerve.It should be appreciated that ability
The those of ordinary skill in domain according to the present invention can conceive without creative work makes many modifications and variations, as long as energy
The adjusting component is transported to via blood vessel close to the neural site for needing to adjust, and operational shape control unit holds electrode
It carries component to change between first shape and the second shape, so that it may realize the purpose of nerve modulation and treatment.For example, can borrow
Mirror is realized application No. is some schemes disclosed by 200780031879.4 and 200980157662.7 Chinese patent application should
The movement of provided device driving shape control unit part specifically can be used in purpose.Therefore, all those skilled in the art
Pass through the available technology of logical analysis, reasoning, or a limited experiment on the basis of existing technology under this invention's idea
Scheme, all should be within the scope of protection determined by the claims.
Claims (18)
1. a kind of for adjusting the device of nerve, including the adjusting component for adjusting the nerve, the adjusting component includes
For will adjust energy transmission to the electrode of the nerve and the electrode load bearing component for being used to carry the electrode, feature exists
In the electrode load bearing component has first shape and the second shape, and the adjusting component is suitble under the first shape
It is moved in blood vessel, described at least one electrode for adjusting component, which is in, under second shape is suitble to pass the adjusting energy
It is delivered to the position of the nerve；Described device further includes for being transported to the adjusting component close to the position of the nerve simultaneously
The control assembly for converting the electrode load bearing component between first shape and the second shape；Under the first shape, institute
Stating and adjusting component in the size radially of blood vessel is 1-2mm；The outer surface of the electrode and the adjacent electrode supporting part
The outer surface in the region of part forms the curved surface of relative smooth；
The control assembly includes the transfer unit for the adjusting component to be transported to the position of the close nerve, described
The shape of transfer unit is elongate, and the distal end of the transfer unit is connected with the proximal end of the electrode load bearing component；
The control assembly includes the shape for converting the electrode load bearing component between first shape and the second shape
Control unit；The first shape of the electrode load bearing component is elongate；Second shape of the electrode load bearing component is spiral
Shape；The spiral diameter is 4-8mm；The number of the electrode is 4, when the electrode load bearing component is in the second shape
When, distance of the adjacent electrode in the axial direction of the blood vessel is 4-6mm；
The inside of the electrode load bearing component and the transfer unit has the shape control for accommodating the shape control unit part
Channel processed, the electrode load bearing component and the shape control unit part are configured to using the shape control unit part in the electricity
The disengaging of the shape control channel of pole load bearing component and become the electrode load bearing component between first shape and the second shape
Change；The shape control unit part is made of the material harder than the material of the electrode load bearing component；When the shape control unit
When part enters the shape control channel of the electrode load bearing component, due to the hardness ratio of the material of the shape control unit part
The electrode load bearing component is big, the shape control unit part can show it is straight or close to straight bar shaped so that the electricity
First shape is presented in pole load bearing component；When the shape control that the shape control unit part is detached from the electrode load bearing component is logical
When road, due to the elastic acting force of the electrode load bearing component itself, the electrode load bearing component is restored to the second shape；It is described
Control assembly includes the handle held for user, and the transfer unit is installed on the handle, and the handle, which has, to be accommodated
The shape control channel of the shape control unit part, the shape control unit part are extended through the shape control channel of the handle
To the outside of the handle；
The distal end of the electrode load bearing component or proximate distal ends are provided with the mark for the show electrode load bearing component position under X-ray
Remember that component, the material of the flag member are platinumiridio；The distal end of the electrode load bearing component is provided with for reducing or keeping away
Exempt from the guard block of vascular damaged, material is selected from one of Pebax2533, Pebax3533, TPU, than electrode supporting part
The material of part is soft.
2. the apparatus according to claim 1, which is characterized in that the nerve is the renal nerve on people's arteria renalis,
Described refers to being located in the arteria renalis " close to the position of the nerve ".
3. the apparatus according to claim 1, which is characterized in that the adjusting refers to be removed by damage or non-damaging mode
Go or reduce the activation of the nerve.
4. the apparatus according to claim 1, which is characterized in that the energy is heat, electromagnetic energy, ultrasonic wave and luminous energy
Middle one or more.
5. the apparatus according to claim 1, which is characterized in that the energy is radio frequency.
6. the apparatus according to claim 1, which is characterized in that the energy is microwave.
7. the apparatus according to claim 1, which is characterized in that the blood vessel is people's arteria renalis.
8. the apparatus according to claim 1, which is characterized in that " being suitble to move in the blood vessel " refers to when described
When adjusting component moves in the blood vessel, the adjusting component does not damage vascular wall.
9. the apparatus according to claim 1, which is characterized in that " being suitble to move in the blood vessel " refers to the tune
Save the internal diameter that component is not more than the blood vessel in the full-size radially of the blood vessel.
10. the apparatus according to claim 1, which is characterized in that described " is suitble to the adjusting energy transmission described in
Nerve position " refer to when the regulating member in the blood vessel when, at least one electrode be in contact vascular wall position.
11. the apparatus according to claim 1, which is characterized in that described " is suitble to the adjusting energy transmission described in
Nerve position " refer to it is described adjusting component the blood vessel full-size radially be 4-8mm, at least one electrode
At full-size.
12. the apparatus according to claim 1, which is characterized in that 4 electricity for adjusting component under second shape
Pole is all in suitable by the adjusting energy transmission to the position of the nerve.
13. the apparatus according to claim 1, which is characterized in that the electrode load bearing component is internally provided with for inciting somebody to action
The electrode is connected to the conducting wire of energy generation apparatus.
14. the apparatus according to claim 1, which is characterized in that the electrode is cyclic annular or tubulose, is socketed on the electrode
The outside of load bearing component.
15. the apparatus according to claim 1, which is characterized in that second shape is the electrode load bearing component not
By the own form under external force.
16. the apparatus according to claim 1, which is characterized in that the material of the transfer unit and the electrode load bearing component
Matter is identical and is linked together.
17. the apparatus according to claim 1, which is characterized in that the transfer unit has can be by the adjusting component
The length of people's arteria renalis is transported to from human radial artery.
18. device according to claim 17, which is characterized in that the length of the transfer unit is 130cm-160cm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310161218.0A CN104127233B (en) | 2013-05-03 | 2013-05-03 | It is a kind of for adjust nerve device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310161218.0A CN104127233B (en) | 2013-05-03 | 2013-05-03 | It is a kind of for adjust nerve device |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104127233A CN104127233A (en) | 2014-11-05 |
| CN104127233B true CN104127233B (en) | 2019-02-22 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310161218.0A Active CN104127233B (en) | 2013-05-03 | 2013-05-03 | It is a kind of for adjust nerve device |
Country Status (1)
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|---|---|
| CN (1) | CN104127233B (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016180327A1 (en) * | 2015-05-13 | 2016-11-17 | 上海魅丽纬叶医疗科技有限公司 | Corrugated radiofrequency ablation catheter having wall-attaching adjustment wires and apparatus thereof |
| CN106852703A (en) * | 2015-12-08 | 2017-06-16 | 上海安通医疗科技有限公司 | A kind of radio frequency ablation catheter for renal artery |
| WO2017132935A1 (en) * | 2016-02-04 | 2017-08-10 | 上海安通医疗科技有限公司 | Multi-electrode renal artery ablation catheter |
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| US6375654B1 (en) * | 2000-05-19 | 2002-04-23 | Cardiofocus, Inc. | Catheter system with working portion radially expandable upon rotation |
| CN1549694A (en) * | 2001-05-01 | 2004-11-24 | �����ɷ� | Helically shaped electrophysiology catheter |
| CN102198015A (en) * | 2011-05-03 | 2011-09-28 | 上海微创电生理医疗科技有限公司 | Retractable spiral laminar ring type electrode catheter |
| CN102274074A (en) * | 2011-05-03 | 2011-12-14 | 上海微创电生理医疗科技有限公司 | Multi-electrode open-type radio frequency ablation catheter |
| CN202437329U (en) * | 2012-01-10 | 2012-09-19 | 上海安通医疗科技有限公司 | Manipulative radiofrequency catheter electrode device |
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|---|---|---|---|---|
| US6171305B1 (en) * | 1998-05-05 | 2001-01-09 | Cardiac Pacemakers, Inc. | RF ablation apparatus and method having high output impedance drivers |
| US9220433B2 (en) * | 2011-06-30 | 2015-12-29 | Biosense Webster (Israel), Ltd. | Catheter with variable arcuate distal section |
| CN102688090A (en) * | 2012-04-29 | 2012-09-26 | 殷跃辉 | Bidirectionally controllable saline-perfusion renal artery radiofrequency ablation catheter |
| CN104095679A (en) * | 2013-04-12 | 2014-10-15 | 上海微创电生理医疗科技有限公司 | Multiple-electrode ablation catheter |
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2013
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Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6375654B1 (en) * | 2000-05-19 | 2002-04-23 | Cardiofocus, Inc. | Catheter system with working portion radially expandable upon rotation |
| CN1549694A (en) * | 2001-05-01 | 2004-11-24 | �����ɷ� | Helically shaped electrophysiology catheter |
| CN102198015A (en) * | 2011-05-03 | 2011-09-28 | 上海微创电生理医疗科技有限公司 | Retractable spiral laminar ring type electrode catheter |
| CN102274074A (en) * | 2011-05-03 | 2011-12-14 | 上海微创电生理医疗科技有限公司 | Multi-electrode open-type radio frequency ablation catheter |
| CN202437329U (en) * | 2012-01-10 | 2012-09-19 | 上海安通医疗科技有限公司 | Manipulative radiofrequency catheter electrode device |
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| Publication number | Publication date |
|---|---|
| CN104127233A (en) | 2014-11-05 |
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