CN104117063A - Composite gel containing traditional Chinese medicine composition and calcium ion and preparation method thereof - Google Patents
Composite gel containing traditional Chinese medicine composition and calcium ion and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a composite gel containing a traditional Chinese medicine composition and calcium ion and a preparation method thereof. The composite gel containing the traditional Chinese medicine composition and calcium ion is composed of the following substances in percent by weight: 10-18% of the traditional Chinese medicine composition, 30-50% of hyaluronic acid or chitosan, 1.2-10.5% of a salt-resistant medicine, 0.03-0.5% of a hormone medicine, 0.15-0.25% of CaCl2, 5.0-15.0% of tranilast and the balance deionized water. The traditional Chinese medicine composition is obtained though clathration of ligusticum wallichii, radix salviae miltiorrhizae and sanguis draxonis by cyclodextrin. The composite gel containing the traditional Chinese medicine composition and calcium ion has relatively good postoperative antistick effect.
Description
Technical field
The present invention relates to post-operation adhesion preventing gel and preparation method thereof, particularly relate to a kind of surgery adhesion prevention compound gel gel containing Chinese medicine composition and calcium ion and preparation method thereof.
Background technology
Tissue adhesion is the common clinical picture of surgical field, is also the pathophysiological process that operation agglutination must occur.As clinical common phenomenon, surgical postoperative adhesion can cause serious clinical complication, as intestinal obstruction, abdominal cavity and pelvic pain, infertility etc., increases the difficulty of operation again and the potential danger that further complication occurs.
The object of Film with Preventing Adhesion is eliminate or reduce the order of severity and the scope that adhesion occurs, and then prevents that the complication being caused by adhesion from occurring.At present, although the anti-postoperative intestinal adhesion preparation that gone on the market has certain effect, but still exist, use inconvenience, be difficult in vivo degraded, need the shortcomings such as operation taking-up.And the anti preparation often using clinically at present still comes with some shortcomings, as large not in molecular weight, concentration is lower, and the interior holdup time of body is short, and some dosage forms are difficult for carrying out large-scale production etc.The more important thing is, Current Domestic is being used outward or the anti preparation developed all can only alleviate scope or the intensity of adhesion, and can not eliminate completely the formation of adhesion.For example: the degradable films that U.S. Genzyme Corporation .Ethicon .Inc. Deng great pharmaceutical factory releases, be widely used in now clinical, but unsatisfactory curative effect, the complication causing for operation after use does not play a role in improving.
Prevention for adhesive ileus, at present mainly from improving operation skill, utilize the aspects such as barrier material and drug combination to set about reducing fibrin deposition, promoting that thereby fibrolysis alleviates excessive adhesion, but due to the uncertainty of operation skill, existing medicine curative effect is unstable and continue medication inconvenience and the shortcoming such as simple mechanical isolation effect is not good.Therefore, this pathologic abdominal adhesions common and that there is no so far effective prophylactico-therapeutic measures is an important topic in anti-tissue fibering proposition always.
Chinese medicine is the rarity of motherland's medical science, this area not yet provide a kind of by Chinese medicine for preventing the method for tissue adhesion.
In sum, traditional post-operation adhesion preventing material all has obvious shortcoming.This technology has solved the problems referred to above well, and preparation is simple, good biocompatibility, and effect is remarkable.The present invention is a kind of novel post-operation adhesion preventing gel.
Rhizoma Chuanxiong: original name rhizome of chuanxiong Qiong, is usually used in blood-activating and qi-promoting, wind-expelling pain-stopping, Main Cultivation in Sichuan, the ground such as Yunnan, Guizhou, Guangxi, Hubei, there is the effect of Radix Saposhnikoviae neuroregulation, not only expanded the blood vessel of original spasm, also make nerve fiber conduction put in place, thereby order is bright skillful with one's hands, experience is abundant; The pungent temperature of Rhizoma Chuanxiong is fragrant dry, walks and does not keep, can go loose, the up top, mountain peak that reaches; Enter again blood system, the descending sea of blood that reaches, blood circulation promoting and blood stasis dispelling effect is extensive, the various diseases of suitable stagnation of blood stasis; Wind-expelling pain-stopping, effectiveness is excellent, can control the diseases such as wind syndrome of head headache, rheumatic arthralgia; It is the gas medicine in blood that former times people calls Rhizoma Chuanxiong, says the functions such as pungent loose, the resolving depression of its residence, sensible, pain relieving.
Sanguis Draxonis has promoting blood circulation to remove blood stasis, analgesic therapy hemostasis, the effect of expelling pus and promoting granulation.Salviamiltiorrhizabung is the herbaceos perennial of Labiatae Salvia, because its dry rhizome color is red and shape is gained the name like ginseng, claims again Herba Wedeliae Wallichii, Radix Salviae Miltiorrhizae, RADIX SALVIAE MILTIORRHIZAE etc.Radix Salviae Miltiorrhizae has stasis-dispelling and pain-killing, the dysmenorrhea of invigorating blood circulation, the effects such as relieving restlessness that clear away heart-fire, the diseases such as main treatment coronary heart diseases and angina pectoris, dysphoria and insomnia, menoxenia.Its main component can roughly be divided into fat-soluble diterpene quinones (Tanshinone II-A) and water solublity salvianolic acid class (danshensu, protocatechualdehyde etc.).
Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae and Sanguis Draxonis have the effect of good hemostasis and anti-inflammation, and it is the growth of anti-bacteria effectively, effectively reduce the probability that wound infection suppurates, and Sanguis Draxonis has good removing heat from blood effect, three kinds of drug combinations, can be effectively antibacterial, improve patient's postoperative quality.
Hyaluronic acid Hyaluronic acid is the main proteoglycan GAG composition of extracellular matrix, in human body, extensively distributes.It is the main component that forms the connective tissues such as human body cell interstitial, vitreum, knuckle synovia, brings into play in vivo water conservation, maintains extracellular space, regulates osmotic pressure, lubricated, the important physiological function that promotes cytothesis.In hyaluronan molecule, contain a large amount of carboxyls and hydroxyl, form in molecule and intermolecular hydrogen bond in aqueous solution, this makes it have powerful water retention, can be in conjunction with self 400 times of above water; When higher concentration, due to three grades of complicated network structure that its intermolecular interaction forms, its aqueous solution has again significant viscoelasticity.Hyaluronic acid, as the main component of intercellular matrix, is participated in the regulation and control that the inside and outside electrolyte of cell exchanges directly, the filter effect of performance physics and molecular information.Macromole hyaluronic acid has inhibitory action to signaling, propagation, differentiation and phagocytic function, and micromolecule hyaluronic acid has facilitation.Hyaluronic acid is for the healing of prevention of postoperative adhesion and promotion skin wound.Hyaluronic acid reacts the compound forming medicine is brought into play to slow releasing function with other medicines, can reach the object of directed and time controlled released.
Hyaluronic acid has lot of advantages aspect medical applications: hyaluronic repetition disaccharide unit all species with in tissue, be all consistent, therefore can not cause the immunologic rejection of hyaluronan molecule self; Hyaluronic polyanion, macromolecule and linear in physicochemical characteristicss such as branched structures, makes hyaluronic acid solution have the viscoelasticity of height; All there is the effective way to hyaluronic acid metabolism in each system of human body.
Tranilast (tranilast) has another name called tranilast, has been proved and has can be good at suppressing fibrosis and inflammation-inhibiting.By the above-mentioned effect of tranilast, can effectively suppress the generation of adhesion.
Chinese patent CN03133843.7 discloses and with medicine, has added the hyaluronic acid derivatives of iron ion for hands post-operation adhesion preventing, it is by being cross-linked hyaluronic acid with iron ion, extend material retention time in vivo, thereby reached the preventing adhesiving effect of long period.But this preventing adhesiving effect is limited, when easy adhesion position occurs damage or infects, can aggravate the adhesion at this position.Therefore, still have the product that needs further research and development to there is better preventing adhesiving effect.
Summary of the invention
The object of the present invention is to provide a kind of preparation simply, good biocompatibility, effect contains surgery adhesion prevention compound gel gel of Chinese medicine composition and calcium ion and preparation method thereof significantly, makes up the deficiency that prior art exists.
For achieving the above object, the present invention adopts following technical scheme:
Containing Chinese medicine composition and calcium ion for preventing a pluralgel for tissue adhesion, described pluralgel is comprised of the material of following percentage by weight:
| Chinese medicine composition | 10-18%， |
| Hyaluronic acid or chitosan | 30-50%， |
| Anti-inflammatory drug | 1.2-10.5% |
| Hormone medicine | 0.03-0.5%， |
| CaCl 2 | 0.15-0.25%， |
| Tranilast | 5.0-15.0%， |
| Deionized water | Surplus; |
Wherein, described Chinese medicine composition is to be obtained after cyclodextrin inclusion compound by Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae and Sanguis Draxonis.
More preferably, described pluralgel is comprised of the material of following percentage by weight:
| Chinese medicine composition | 13-15%， |
| Hyaluronic acid or chitosan | 35-50%， |
| Anti-inflammatory drug | 5.8-8.5% |
| Hormone medicine | 0.03-0.24%， |
| CaCl 2 | 0.20-0.25%， |
| Tranilast | 10.5-15.0%， |
| Deionized water | Surplus; |
The present invention containing Chinese medicine composition and calcium ion for preventing the pluralgel of tissue adhesion, described hyaluronic acid can also be derivatives of hyaluronic acids; Described CaCl2 can also use calcium citrate, calcium gluconate, calcium hydrogen phosphate or calcium lactate to replace; Described antibiotic medicine is streptomycin, one or more in tetracycline or erythromycin, and described hormone medicine is a kind of in dexamethasone, hydrocortisone or prednisone; And described Chinese medicine composition Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, the ratio of Sanguis Draxonis is 1～3:1～3:2～3.
The present invention also provide a kind of containing Chinese medicine composition and calcium ion for preventing the preparation method of the pluralgel of tissue adhesion, comprise the steps:
(1), hyaluronic acid or chitosan are dissolved in and in deionized water, obtain the solution A that mass concentration is 0.1～20wt%;
(2), 0.1～10wt%CaCl2 solution is dropwise added in solution A, stir simultaneously, make the two fully be mixed to get mixed gel B, wherein the volume ratio of CaCl2 solution and hyaluronic acid solution A is 0.1～20: 100, and regulating pH value is 7;
(3), by B lyophilizing, be pressed into powder C;
(4), by Chinese medicine composition Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Sanguis Draxonis is pulverized, and sieves, and adds cyclodextrin, makes clathrate D;
(5), by above-mentioned powder C, D sterilization 3 times;
(6), above-mentioned powder C and tranilast drug powder are mixed by 0.1～20: 1 part by weight after, be dissolved in deionized water, fully stir;
(7), by clathrate D, anti-inflammatory drug, hormone medicine, mixes, and adds in (6), obtains containing Chinese medicine composition, calcium ion for preventing the pluralgel of tissue adhesion.
Or adopt the method comprise the steps prepare the present invention containing Chinese medicine composition and calcium ion for preventing the pluralgel of tissue adhesion:
(1), hyaluronic acid or chitosan are dissolved in and in deionized water, obtain the solution A that mass concentration is 0.1～20wt%;
(2), 0.1～10wt%CaCl2 solution is dropwise added in solution A, stir simultaneously, make the two fully be mixed to get mixed gel B, the volume ratio of CaCl2 solution and chitosan solution A is 0.1～20: 100, and regulating pH value is 7;
(3), by Chinese medicine composition Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Sanguis Draxonis is pulverized, and sieves, and adds cyclodextrin, makes clathrate D;
(4), gel B and tranilast drug powder are mixed by 0.1～20: 1 part by weight after, be dissolved in deionized water, fully stir;
(5), by clathrate D, anti-inflammatory drug, hormone medicine mixes, and adds in (4), obtains containing Chinese medicine composition, calcium ion for preventing the pluralgel of tissue adhesion.
Or adopt the method comprise the steps prepare the present invention containing Chinese medicine composition and calcium ion for preventing the pluralgel of tissue adhesion:
(1), hyaluronic acid or chitosan are dissolved in and in deionized water, obtain the solution A that mass concentration is 0.1～20wt%;
(2), 0.1～10wt%CaCl2 solution is dropwise added in hyaluronic acid solution A, stir simultaneously, make the two fully be mixed to get mixed gel B, the volume ratio of CaCl2 solution and solution A is 0.1～20: 100, and regulating pH value is 7;
(3), B is adopted to high temperature drying or air-dry, then be pressed into powder C;
(4), by Chinese medicine composition Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Sanguis Draxonis is pulverized, and sieves, and adds cyclodextrin, makes clathrate D;
(5), above-mentioned powder C and clathrate D are adopted to ultra-vioket radiation or Co60 illumination-based disinfection;
(6), by sterilization after powder C and clathrate D with tranilast drug powder by 0.1～20: after 0.1～20: 1 part by weight mixes, be dissolved in deionized water, fully stirring;
(7), by anti-inflammatory drug, hormone medicine, mixes, and adds in (6), obtains containing Chinese medicine composition, calcium ion for preventing the pluralgel of tissue adhesion.
Preparation method formula of the present invention is simple, and preparation technology easily goes, and can prepare at short notice postoperative novel anti-adhesion gel.Originally the pluralgel good biocompatibility making, preventing adhesiving effect is remarkable.
The specific embodiment
Below in conjunction with specific embodiment, the present invention is described in further details:
Containing Chinese medicine composition and calcium ion for preventing a pluralgel for tissue adhesion, percentage by weight is composed as follows:
| Chinese medicine composition | 12%， |
| Hyaluronic acid | 40%， |
| Streptomycin | 2.6% |
| Dexamethasone | 0.15%， |
| CaCl2 | 0.22%， |
| Tranilast | 5.8%， |
| Deionized water | Surplus; |
Preparation method is:
(1), hyaluronic acid is dissolved in to the hyaluronic acid solution A that obtains 10wt% in deionized water;
(2), 10wt%CaCl2 solution is dropwise added in hyaluronic acid solution A, stir simultaneously, make the two fully be mixed to get mixed gel B, the volume ratio of CaCl2 solution and hyaluronic acid solution A is 15: 100, and regulating pH value is 7;
(3), by B by freeze dryer lyophilizing, be pressed into powder C;
(4), by Chinese medicine composition Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Sanguis Draxonis is pulverized, three's ratio is that 1:2:3 sieves, and adds cyclodextrin, makes clathrate D;
(5), by above-mentioned powder C, D sterilization 3 times;
(6), above-mentioned powder C and tranilast drug powder are mixed by the part by weight of 5: 1 after, be dissolved in deionized water, fully stir;
(7), clathrate D, streptomycin, dexamethasone are mixed, add in (6), obtain containing Chinese medicine composition, calcium ion for preventing the pluralgel of tissue adhesion.
Embodiment 2
Containing Chinese medicine composition and calcium ion for preventing a pluralgel for tissue adhesion, percentage by weight is composed as follows:
| Chinese medicine composition | 10%， |
| Hyaluronic acid | 38%， |
| Erythromycin | 7.6% |
| Hydrocortisone | 0.21%， |
| CaCl2 | 0.18%， |
| Tranilast | 9.5%， |
| Deionized water | Surplus; |
Preparation method is:
(1), hyaluronic acid is dissolved in to the hyaluronic acid solution A that obtains 20wt% in deionized water;
(2), 5wt%CaCl2 solution is dropwise added in hyaluronic acid solution A, stir simultaneously, make the two fully be mixed to get mixed gel B, the volume ratio of CaCl2 solution and hyaluronic acid solution A is 20: 100, and regulating pH value is 7;
(3), by B by freeze dryer lyophilizing, be pressed into powder C;
(4), by Chinese medicine composition Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Sanguis Draxonis is pulverized, three's ratio is that 2:2:3 sieves, and adds cyclodextrin, makes clathrate D;
(5), by above-mentioned powder C, D sterilization 3 times;
(6), above-mentioned powder C and tranilast drug powder are mixed by the part by weight of 5: 1 after, be dissolved in deionized water, fully stir;
(7), clathrate D, erythromycin, hydrocortisone are mixed, add in (6), obtain containing Chinese medicine composition, calcium ion for preventing the pluralgel of tissue adhesion.
Embodiment 3
Containing Chinese medicine composition and calcium ion for preventing a pluralgel for tissue adhesion, percentage by weight is composed as follows:
| Chinese medicine composition | 15%， |
| Chitosan | 35%， |
| Erythromycin | 5.6% |
| Hydrocortisone | 0.19%， |
| CaCl2 | 0.21%， |
| Tranilast | 11.6%， |
| Deionized water | Surplus; |
Preparation method is:
(1), chitosan is dissolved in to the chitosan solution A that obtains 15wt% in deionized water;
(2), 6wt%CaCl2 solution is dropwise added in chitosan solution A, stir simultaneously, make the two fully be mixed to get mixed gel B, the volume ratio of CaCl2 solution and chitosan solution A is 5: 100, and regulating pH value is 7;
(3), by Chinese medicine composition Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Sanguis Draxonis is pulverized, three's ratio is that 3:2:1 sieves, and adds cyclodextrin, makes clathrate D;
(4), gel B and tranilast drug powder are mixed by the part by weight of 0.1: 1 after, be dissolved in deionized water, fully stir;
(5), by clathrate D, erythromycin, hydrocortisone mixes, and adds in (4), obtains containing Chinese medicine composition, calcium ion for preventing the pluralgel of tissue adhesion.
Embodiment 4
Containing Chinese medicine composition and calcium ion for preventing a pluralgel for tissue adhesion, percentage by weight is composed as follows:
| Chinese medicine composition | 11%， |
| Hyaluronic acid | 46%， |
| Streptomycin and tetracycline | 8.4% |
| Prednisone | 0.12%， |
| CaCl2 | 0.23%， |
| Tranilast | 8.0%， |
| Deionized water | Surplus; |
Preparation method is:
(1), hyaluronic acid is dissolved in to the hyaluronic acid solution A that obtains 12wt% in deionized water;
(2), 0.1wt%CaCl2 solution is dropwise added in hyaluronic acid solution A, stir simultaneously, make the two fully be mixed to get mixed gel B, the volume ratio of CaCl2 solution and hyaluronic acid solution A is 20: 100, and regulating pH value is 7;
(3), B is adopted to high temperature drying or air-dry, then be pressed into powder C;
(4), by Chinese medicine composition Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Sanguis Draxonis is pulverized, three's ratio is that 2:3:2 sieves, and adds cyclodextrin, makes clathrate D;
(5), by the sterilization method of above-mentioned powder C and clathrate D employing ultra-vioket radiation or Co60 irradiation;
(6), above-mentioned powder C and clathrate D and tranilast drug powder are mixed by the part by weight of 20: 5: 1 after, be dissolved in deionized water, fully stir;
(7), by streptomycin and tetracycline, prednisone medicine, mixes, and adds in (6), obtains containing Chinese medicine composition, calcium ion for preventing the pluralgel of tissue adhesion.
Embodiment 5
Containing Chinese medicine composition and calcium ion for preventing a pluralgel for tissue adhesion, percentage by weight is composed as follows:
| Chinese medicine composition | 14%， |
| Chitosan | 33%， |
| Streptomycin and tetracycline | 9.0% |
| Prednisone | 0.35%， |
| CaCl2 | 0.18%， |
| Tranilast | 8.6%， |
| Deionized water | Surplus; |
Preparation method is:
(1), chitosan is dissolved in to the chitosan solution A that obtains 0.5% in deionized water;
(2), 0.1wt%CaCl2 solution is dropwise added in chitosan solution A, stir simultaneously, make the two fully be mixed to get mixed gel B, the volume ratio of CaCl2 solution and chitosan solution A is 0.1: 100, and regulating pH value is 7;
(3), by Chinese medicine composition Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Sanguis Draxonis is pulverized, three's ratio is that 1:2:2 sieves, and adds cyclodextrin, makes clathrate D;
(4), gel B and tranilast drug powder are mixed by the part by weight of 20: 1 after, be dissolved in deionized water, fully stir;
(5), by clathrate D, streptomycin and tetracycline, prednisone medicament mixed, adds in (4), obtains containing Chinese medicine composition, calcium ion for preventing the pluralgel of tissue adhesion.
Embodiment 6
Containing Chinese medicine composition and calcium ion for preventing a pluralgel for tissue adhesion, percentage by weight is composed as follows:
| Chinese medicine composition | 11.0%， |
| Chitosan | 42%， |
| Tetracycline | 3.5% |
| Hydrocortisone | 0.33%， |
| CaCl2 | 0.15%， |
| Tranilast | 9.2%， |
| Deionized water | Surplus; |
Preparation method is:
(1), chitosan is dissolved in to the chitosan solution A that obtains 0.8% in deionized water;
(2), 0.1wt%CaCl2 solution is dropwise added in chitosan solution A, stir simultaneously, make the two fully be mixed to get mixed gel B, the volume ratio of CaCl2 solution and chitosan solution A is 8: 100, and regulating pH value is 7;
(3), by Chinese medicine composition Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Sanguis Draxonis is pulverized, three's ratio is that 1:3:2 sieves, and adds cyclodextrin, makes clathrate D;
(4), gel B and tranilast drug powder are mixed by the part by weight of 8: 1 after, be dissolved in deionized water, fully stir;
(5), clathrate D, tetracycline, hydrocortisone are mixed, add in (4), obtain containing Chinese medicine composition, calcium ion for preventing the pluralgel of tissue adhesion.
Test example: the adhesion prevention effect of organ
In order to confirm that gel prevents the effect of organ adhesion, use the pluralgel of embodiment 1 preparation to process experimental animal, and compare with the matched group that gel-free is processed.
1, experimental technique:
Use 50 Donryu rats (male, 5 to 7 week age) to test.Under rat body anesthesia, open abdomen (abdominal part medisection) to excise the about 1 * 2cm of stomach wall of the adjacent ileocecum portion top of large intestine.Then, ileocecum portion is taken out to outside abdominal cavity, with gauze wiping to its serosal surface, occurs little ecchymosis.Next, use exsiccator blowing warm air approximately 20 seconds, and be dried approximately 10 minutes under indoor environment.To scratch position and the peritoneum of 25 Donryu rat ileocecum portions wherein and the part coating 0.2g pluralgel of the present invention that excised stomach wall, other 25 Donryu do not do coating and process.After 1 week, abdominal cavity is opened in operation, observes adhesion degree and infection conditions.
2, experimental result:
Through pluralgel of the present invention, process and undressed rat organ's adhesion and result of infection see the following form:
| ? | The number sticking together | There is the number infecting |
| Through pluralgel of the present invention, process | 0 | 1 |
| Without pluralgel of the present invention, process | 25 | 22 |
3, conclusion:
Experimental result shows, the operative site of 25 Donryu rats being coated with to pluralgel of the present invention after 1 week, does not occur adhesion and infection, shows that the pluralgel that the present invention contains Chinese medicine composition and calcium ion has good post-operation adhesion preventing effect.
Claims (8)
1. containing a pluralgel for Chinese medicine composition and calcium ion, it is characterized in that pluralgel is comprised of the material of following percentage by weight:
Wherein, described Chinese medicine composition is to be obtained after cyclodextrin inclusion compound by Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae and Sanguis Draxonis.
2. pluralgel as claimed in claim 1, is characterized in that pluralgel is comprised of the material of following percentage by weight:
Wherein, described Chinese medicine composition is to be obtained after cyclodextrin inclusion compound by Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae and Sanguis Draxonis.
3. pluralgel as claimed in claim 1 or 2, is characterized in that: described hyaluronic acid is derivatives of hyaluronic acids.
4. pluralgel as claimed in claim 1 or 2, is characterized in that: described antibiotic medicine is one or more in streptomycin, tetracycline or erythromycin; Described hormone medicine is a kind of in dexamethasone, hydrocortisone or prednisone.
5. pluralgel as claimed in claim 1 or 2, is characterized in that: in described Chinese medicine composition, the weight ratio of Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Sanguis Draxonis is 1～3:1～3:2～3.
6. a preparation method for the pluralgel containing Chinese medicine composition and calcium ion as claimed in claim 1, is characterized in that: comprise the steps:
(1), hyaluronic acid or chitosan are dissolved in and in deionized water, obtain the solution A that mass concentration is 0.1～20wt%;
(2), 0.1～10wt%CaCl2 solution is dropwise added in solution A, stir simultaneously, make the two fully be mixed to get mixed gel B, wherein the volume ratio of CaCl2 solution and hyaluronic acid solution A is 0.1～20: 100, and regulating pH value is 7;
(3), by B lyophilizing, be pressed into powder C;
(4), by Chinese medicine composition Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Sanguis Draxonis is pulverized, and sieves, and adds cyclodextrin, makes clathrate D;
(5), by above-mentioned powder C, D sterilization 3 times;
(6), above-mentioned powder C and tranilast drug powder are mixed by 0.1～20: 1 part by weight after, be dissolved in deionized water, fully stir;
(7), by clathrate D, anti-inflammatory drug, hormone medicine, mixes, and adds in (6), obtains containing Chinese medicine composition, calcium ion pluralgel.
7. a preparation method for the pluralgel containing Chinese medicine composition and calcium ion as claimed in claim 1, is characterized in that: comprise the steps:
(1), hyaluronic acid or chitosan are dissolved in and in deionized water, obtain the solution A that mass concentration is 0.1～20wt%;
(2), 0.1～10wt%CaCl2 solution is dropwise added in solution A, stir simultaneously, make the two fully be mixed to get mixed gel B, the volume ratio of CaCl2 solution and chitosan solution A is 0.1～20: 100, and regulating pH value is 7;
(3), by Chinese medicine composition Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Sanguis Draxonis is pulverized, and sieves, and adds cyclodextrin, makes clathrate D;
(4), gel B and tranilast drug powder are mixed by 0.1～20: 1 part by weight after, be dissolved in deionized water, fully stir;
(5), by clathrate D, anti-inflammatory drug, hormone medicine mixes, and adds in (4), obtains containing Chinese medicine composition, calcium ion pluralgel.
8. a preparation method for the pluralgel containing Chinese medicine composition and calcium ion as claimed in claim 1, is characterized in that: comprise the steps:
(1), hyaluronic acid or chitosan are dissolved in and in deionized water, obtain the solution A that mass concentration is 0.1～20wt%;
(2), 0.1～10wt%CaCl2 solution is dropwise added in hyaluronic acid solution A, stir simultaneously, make the two fully be mixed to get mixed gel B, the volume ratio of CaCl2 solution and solution A is 0.1～20: 100, and regulating pH value is 7;
(3), B is adopted to high temperature drying or air-dry, then be pressed into powder C;
(4), by Chinese medicine composition Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Sanguis Draxonis is pulverized, and sieves, and adds cyclodextrin, makes clathrate D;
(5), above-mentioned powder C and clathrate D are adopted to ultra-vioket radiation or Co60 illumination-based disinfection;
(6), by sterilization after powder C and clathrate D with tranilast drug powder by 0.1～20: after 0.1～20: 1 part by weight mixes, be dissolved in deionized water, fully stirring;
(7), by anti-inflammatory drug, hormone medicine, mixes, and adds in (6), obtains containing Chinese medicine composition, calcium ion pluralgel.
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| CN201310142466.0A CN104117063B (en) | 2013-04-24 | 2013-04-24 | A kind of plural gel for being used to prevent post-operation adhesion containing Chinese medicine composition and calcium ion and preparation method thereof |
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| CN104117063A true CN104117063A (en) | 2014-10-29 |
| CN104117063B CN104117063B (en) | 2017-09-19 |
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Cited By (2)
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| CN104706895A (en) * | 2015-03-02 | 2015-06-17 | 李仲昆 | Preparation of dragon's blood beta-cyclodextrin skin external preparation |
| CN105999429A (en) * | 2016-06-16 | 2016-10-12 | 湖州科达化工燃料有限公司 | Absorbable anti-adhesion film |
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| CN1827179A (en) * | 2005-03-04 | 2006-09-06 | 蒋婧 | Post-surgery functional barrier film and method for preparing the same |
| CN101879334A (en) * | 2010-06-21 | 2010-11-10 | 甘少磊 | Surgery adhesion prevention compound gel material containing calcium ions and hyaluronic acid and preparation method thereof |
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| CN1827179A (en) * | 2005-03-04 | 2006-09-06 | 蒋婧 | Post-surgery functional barrier film and method for preparing the same |
| CN101879334A (en) * | 2010-06-21 | 2010-11-10 | 甘少磊 | Surgery adhesion prevention compound gel material containing calcium ions and hyaluronic acid and preparation method thereof |
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| 余建等: "子宫内膜异位症腹腔镜手术联合中西药物治疗的临床研究", 《中国医药指南》 * |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104706895A (en) * | 2015-03-02 | 2015-06-17 | 李仲昆 | Preparation of dragon's blood beta-cyclodextrin skin external preparation |
| CN105999429A (en) * | 2016-06-16 | 2016-10-12 | 湖州科达化工燃料有限公司 | Absorbable anti-adhesion film |
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| Publication number | Publication date |
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| CN104117063B (en) | 2017-09-19 |
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