CN104111344B - The full-automatic sample introduction mechanism of a kind of flow cytometer - Google Patents
The full-automatic sample introduction mechanism of a kind of flow cytometer Download PDFInfo
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- CN104111344B CN104111344B CN201410221782.1A CN201410221782A CN104111344B CN 104111344 B CN104111344 B CN 104111344B CN 201410221782 A CN201410221782 A CN 201410221782A CN 104111344 B CN104111344 B CN 104111344B
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Abstract
<b> the invention discloses the full-automatic sample introduction mechanism of a kind of flow cytometer, comprise the rotating disc being radially distributed with some test tube mounting holes, be located at </b><bGreatT.Gre aT.GTX</b><bGrea tT.GreaT.GT on the fixed head of rotating disc side to driving mechanism, and the sampling probe to be connected to driving mechanism with </b><bGreatT.Gre aT.GTX</b><bGrea tT.GreaT.GT and </b><bGreatT.Gre aT.GTZ</b><bGrea tT.GreaT.GT are to driving mechanism, </b><bGreatT.Gre aT.GTX</b><bGrea tT.GreaT.GT comprises to driving mechanism and is located at </b><bGreatT.Gre aT.GTX</b><bGrea tT.GreaT.GT on fixed head to slide rail, be located at </b><bGreatT.Gre aT.GTX</b><bGrea tT.GreaT.GT to the sampling probe drive plate on slide rail, and the steering wheel bar-link drive for driving sampling probe drive plate to do horizontal reciprocating movement along </b><bGreatT.Gre aT.GTX</b><bGrea tT.GreaT.GT to slide rail, simultaneously </b><bGreatT.Gre aT.GTZ</b><bGrea tT.GreaT.GT connects the base of rotating disc by web joint and driven rotary dish is </b><bGreatT.Gre aT.GTZ</b><bGrea tT.GreaT.GT to vertical to-and-fro movement to driving mechanism, and web joint is connected with base by the rotary extension axle arranged along rotating disc radial direction, the </b><bGreatT.Gre aT.GTX</b><bGrea tT.GreaT.GT be located on fixed head is adopted to drive the sampling probe be located on sampling probe drive plate to do horizontal reciprocating movement along </b><bGreatT.Gre aT.GTX</b><bGrea tT.GreaT.GT to slide rail to slide rail and steering wheel bar-link drive, not only structure is simple, and it is little to take up room, sampling probe tangential movement is also more stable.</b>
Description
Technical field
the present invention relates to a kind of sample introduction mechanism, especially relate to the full-automatic sample introduction mechanism of a kind of flow cytometer.
Background technology
flow cytometer (Flowcytometry) is device cell being carried out to automatic analysis and sorting.It can a series of important biophysics of the cell dispersion that floats on a liquid of Quick Measurement, storage, display, the characteristic parameter of biological chemistry aspect, and according to the parameter ranges of preliminary election, the cell subsets of specifying therefrom can be sorted out.
in prior art, flow cytometer has an important step namely to sample link before measurements, for the sample introduction mechanism of flow cytometer of the prior art, drive motor is adopted to drive sampling probe to sample, not only increase flow cytometer entirety to take up room, and adopt drive motor Direct driver, easily cause sampling probe to move unstable, sampling precision is low, simultaneously because flow cytometer samples from test tube, and the test tube bore adopted in prior art is general narrower, when extracting liquid to be detected, rabbling mechanism cannot be added, cause the data that detect inaccurate, for above-mentioned technical matters, prior art also teaches and a kind ofly sample stirring integrated sampling mechanism, comprise a vibrating reed swung, this vibrating reed is connected with sampling probe, sampling probe is driven to swing or swing by vibrating reed, swaying direction is single, mixing effect is bad, and hunting range is not easy to control, namely sampling probe easily encounters inboard wall of test tube in the process swung, serious even breaking-up test tube and sampling probe.
Summary of the invention
the present invention seeks to: provide that a kind of structure is simple, take up room the little and full-automatic sample introduction mechanism of the flow cytometer of good stability.
technical scheme of the present invention is: the full-automatic sample introduction mechanism of a kind of flow cytometer, comprise the rotating disc being radially distributed with some test tube mounting holes, be located at X on the fixed head of described rotating disc side to driving mechanism, and the sampling probe to be connected to driving mechanism with described X and Z-direction driving mechanism, described X comprises to driving mechanism and is located at X on described fixed head to slide rail, be located at described X to the sampling probe drive plate on slide rail, and the steering wheel bar-link drive for driving described sampling probe drive plate to do horizontal reciprocating movement along X to slide rail, described Z-direction driving mechanism connects the base of described rotating disc by web joint and drives described rotating disc to do the vertical to-and-fro movement of Z-direction simultaneously, and described web joint is connected with described base by the rotary extension axle arranged along described rotating disc radial direction.
preferably, described steering wheel bar-link drive comprises the steering wheel be located on described sampling probe drive plate, and the two-stage connecting rod that one end is connected with described fixed head, the other end is connected with described steering wheel.
preferably, described Z-direction driving mechanism comprises the Z-direction guide rail be fixedly connected with described sampling probe drive plate, and described web joint is connected with the slide block on described Z-direction guide rail and drives described rotating disc to do vertical to-and-fro movement along Z-direction guide rail.
preferably, also comprise sampling probe vibrating mechanism, described sampling probe vibrating mechanism comprises the holder be connected with described web joint, be located at the vibrating motor on described holder, the eccentric wheel apparatus be connected with described vibrating motor output terminal, and by the oscillating plate that web member is connected with described eccentric wheel apparatus, described sampling probe one end is through described oscillating plate.
preferably, be provided with damping elastic piece between described rotating disc and its base, this damping elastic piece is used for the effect of vibration of slowing down vibration plate for rotating disc.
preferably, described sampling probe vibrating mechanism also comprises the electromagnet be located on described holder, and the armature be located at below described electromagnet, described armature one end is set on described web member, and the top of described web member is connected with described eccentric wheel apparatus is detachable by bearing.
preferably, described oscillating plate is connected with the elastic component for keeping oscillating plate to do horizontal eccentric motion, the top of described elastic component is connected with described holder.
more preferably, described elastic component is spring.
advantage of the present invention is:
1. the present invention adopts the X be located on fixed head to drive the sampling probe be located on sampling probe drive plate to do horizontal reciprocating movement along X to slide rail to slide rail and steering wheel bar-link drive, not only structure is simple, and it is little to take up room, sampling probe tangential movement is also more stable;
2. the present invention is when sampling probe inserts test tube sampling, the eccentric wheel apparatus in sampling probe vibrating mechanism is adopted to drive oscillating plate to do eccentric motion, thus drive sampling probe to do eccentric motion further, and stir invisible spectro testing liquid, mixing effect comparatively prior art is better, thus further increases sampling precision;
3. the present invention adopts the sampling probe of sampling, agitating function one, while saving equipment cost, space shared by reduction equipment, and adopt eccentric wheel apparatus to be convenient to control sampling probe in vitro to move within wall scope, effectively prevent sampling probe in motion process from touching test tube wall, even cause sampling probe or test tube wall breakage, be applicable to the test tube stirring sampling that bore is narrower;
4. the present invention adopts electromagnet and armature cooperation to make sampling probe have automatic reset function after completion of stirring, and namely sampling probe after completion of stirring, automatically returns to initial position, and then sample;
5. the present invention adopts elastic component connection fixing base and oscillating plate, effectively prevents sampling probe from tilting, and ensures that oscillating plate does eccentric motion in the horizontal direction.
Accompanying drawing explanation
below in conjunction with drawings and Examples, the invention will be further described:
fig. 1 is the front view of the full-automatic sample introduction mechanism of flow cytometer of the present invention;
fig. 2 is the side view of the full-automatic sample introduction mechanism of flow cytometer of the present invention;
fig. 3 X of the present invention is to driving mechanism, Z-direction driving mechanism and sampling probe vibrating mechanism schematic diagram;
fig. 4 is sampling probe vibrating mechanism stereographic map of the present invention;
fig. 5 is sampling probe vibrating mechanism vertical view of the present invention;
fig. 6 is the A-A face cut-open view of Fig. 5 of the present invention;
fig. 7 is the B-B face cut-open view of Fig. 5 of the present invention;
wherein: 1 rotating disc, 2 fixed heads, 3 sampling probes, 4aX is to slide rail, 4b sampling probe drive plate, 4c-1 steering wheel, 4c-2 two-stage connecting rod, 5 web joints, 6 bases, 7 rotary extension axles, 8aZ direction guiding rail, 8b slide block, 9a holder, 9b vibrating motor, 9c eccentric wheel apparatus, 9d web member, 9e oscillating plate, 9f electromagnet, 9g armature, 9h bearing, 9i spring.
Embodiment
embodiment: shown in 7, the full-automatic sample introduction mechanism of a kind of flow cytometer, comprise the rotating disc 1 being radially distributed with some test tube mounting holes, be located at X on rotating disc 1 side fixed head 2 to driving mechanism, and the sampling probe 3 to be connected to driving mechanism with X and Z-direction driving mechanism, X comprises to driving mechanism and is located at X on fixed head 2 to slide rail 4a, be located at X to the sampling probe drive plate 4b on slide rail 4a, and the steering wheel bar-link drive for driving sampling probe drive plate 4b to do horizontal reciprocating movement along X to slide rail 4a, this steering wheel bar-link drive comprises the steering wheel 4c-1 be located on sampling probe drive plate 4b, and one end is connected with fixed head 2, the two-stage connecting rod 4c-2 that the other end is connected with steering wheel 4c-1, simultaneously Z-direction driving mechanism connects the base 6 of rotating disc 1 by web joint 5 and driven rotary dish 1 does the vertical to-and-fro movement of Z-direction, this Z-direction driving mechanism comprises the Z-direction guide rail 8a be fixedly connected with sampling probe drive plate 4b, web joint 5 is connected with the slide block 8b on Z-direction guide rail 8a and driven rotary dish 1 does vertical to-and-fro movement along Z-direction guide rail 8a, and web joint 5 is connected with base 6 by the rotary extension axle 7 arranged along rotating disc 1 radial direction, the present invention adopts the X be located on fixed head 2 to drive the sampling probe 3 be located on sampling probe drive plate 4b to do horizontal reciprocating movement along X to slide rail 4a to slide rail 4a and steering wheel bar-link drive, not only structure is simple, and it is little to take up room, sampling probe 3 tangential movement is also more stable.
with reference to shown in Fig. 3 to 7, the full-automatic sample introduction mechanism of flow cytometer of the present invention also comprises sampling probe vibrating mechanism, sampling probe vibrating mechanism comprises the holder 9a be connected with web joint 5, be located at the vibrating motor 9b on holder 9a, the eccentric wheel apparatus 9c be connected with vibrating motor 9b output terminal, and the oscillating plate 9e to be connected with eccentric wheel apparatus 9c by web member 9d, sampling probe 3 one end is through oscillating plate 9e, when sampling probe 3 inserts test tube sampling, the eccentric wheel apparatus 9c in sampling probe vibrating mechanism is adopted to drive oscillating plate 9e to do eccentric motion, thus drive sampling probe 3 to do eccentric motion further, and stir invisible spectro testing liquid, mixing effect comparatively prior art is better, thus further increase sampling precision, adopt sampling simultaneously, the sampling probe of agitating function one, while saving equipment cost, space shared by reduction equipment, and adopt eccentric wheel apparatus 9c to be convenient to control sampling probe 3 in vitro to move within wall scope, effectively prevent sampling probe 3 in motion process from touching test tube wall, even cause sampling probe 3 or test tube wall breakage, be applicable to the test tube stirring sampling that bore is narrower, this sampling probe vibrating mechanism also comprises the electromagnet 9f be located on holder 9a, and the armature 9g be located at below electromagnet 9f, armature 9g one end is set on web member 9d, the top of this web member 9d is connected with eccentric wheel apparatus 9c is detachable by bearing 9h, the present invention adopts electromagnet 9f and armature 9g cooperation to make sampling probe 3 have automatic reset function after completion of stirring, namely sampling probe 3 after completion of stirring, automatically returns to initial position, and then samples, between rotating disc 1 and its base 6, be provided with damping elastic piece (figure does not draw) simultaneously, this damping elastic piece is used for the effect of vibration of slowing down vibration plate 9e for rotating disc 1, this oscillating plate 9e is connected with the spring 9i for keeping oscillating plate 9e to do horizontal eccentric motion, the top of described spring 9i is connected with described holder 9a, adopt spring 9i connection fixing base 9a and oscillating plate 9e, effectively prevent sampling probe 3 from tilting, ensure that oscillating plate 9e does eccentric motion in the horizontal direction.
above-described embodiment, only for technical conceive of the present invention and feature are described, its object is to person skilled in the art can be understood content of the present invention and implement according to this, can not limit the scope of the invention with this.All equivalences done according to Spirit Essence of the present invention change or modify, and all should be encompassed within protection scope of the present invention.
Claims (6)
1. the full-automatic sample introduction mechanism of flow cytometer, comprise the rotating disc (1) being radially distributed with some test tube mounting holes, be located at X on described rotating disc (1) side fixed head (2) to driving mechanism, and the sampling probe (3) to be connected to driving mechanism with described X and Z-direction driving mechanism, it is characterized in that, described X comprises to driving mechanism and is located at X on described fixed head (2) to slide rail (4a), be located at described X to the sampling probe drive plate (4b) on slide rail (4a), and the steering wheel bar-link drive for driving described sampling probe drive plate (4b) to do horizontal reciprocating movement along X to slide rail (4a), described Z-direction driving mechanism is connected the base (6) of described rotating disc (1) by web joint (5) and is driven described rotating disc (5) to do the vertical to-and-fro movement of Z-direction simultaneously, and described web joint (5) is connected with described base (6) by the rotary extension axle (7) arranged along described rotating disc (1) radial direction, also comprise sampling probe vibrating mechanism, described sampling probe vibrating mechanism comprises the holder (9a) be connected with described web joint (5), be located at the vibrating motor (9b) on described holder (9a), the eccentric wheel apparatus (9c) be connected with described vibrating motor (9b) output terminal, and the oscillating plate (9e) to be connected with described eccentric wheel apparatus (9c) by web member (9d), described sampling probe (3) one end is through described oscillating plate (9e), described sampling probe vibrating mechanism also comprises the electromagnet (9f) be located on described holder (9a), and be located at the armature (9g) of described electromagnet (9f) below, described armature (9g) one end is set on described web member (9d), the top of described web member (9d) is connected with described eccentric wheel apparatus (9c) is detachable by bearing (9h).
2. the full-automatic sample introduction mechanism of flow cytometer according to claim 1, it is characterized in that, described steering wheel bar-link drive comprises the steering wheel (4c-1) be located on described sampling probe drive plate (4b), and the two-stage connecting rod (4c-2) that one end is connected with described fixed head (2), the other end is connected with described steering wheel (4c-1).
3. the full-automatic sample introduction mechanism of flow cytometer according to claim 1, it is characterized in that, described Z-direction driving mechanism comprises the Z-direction guide rail (8a) be fixedly connected with described sampling probe drive plate (4b), and described web joint (5) is connected with the slide block (8b) on described Z-direction guide rail (8a) and drives described rotating disc (1) to do vertical to-and-fro movement along Z-direction guide rail (8a).
4. the full-automatic sample introduction mechanism of flow cytometer according to claim 1, is characterized in that, is provided with damping elastic piece between described rotating disc (1) and its base (6).
5. the full-automatic sample introduction mechanism of flow cytometer according to claim 1, it is characterized in that, described oscillating plate (9e) is connected with the elastic component for keeping oscillating plate (9e) to do horizontal eccentric motion, the top of described elastic component is connected with described holder (9a).
6. the full-automatic sample introduction mechanism of flow cytometer according to claim 5, is characterized in that, described elastic component is spring (9i).
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| Application Number | Priority Date | Filing Date | Title |
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| CN201410221782.1A CN104111344B (en) | 2014-05-23 | 2014-05-23 | The full-automatic sample introduction mechanism of a kind of flow cytometer |
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| CN201410221782.1A CN104111344B (en) | 2014-05-23 | 2014-05-23 | The full-automatic sample introduction mechanism of a kind of flow cytometer |
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| CN104111344A CN104111344A (en) | 2014-10-22 |
| CN104111344B true CN104111344B (en) | 2016-04-13 |
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| CN104913946B (en) * | 2015-05-26 | 2017-07-11 | 中山市创艺生化工程有限公司 | A kind of grabbing device for cellanalyzer |
| CN106706370A (en) * | 2016-12-30 | 2017-05-24 | 聚光科技(杭州)股份有限公司 | Automatic water quality sampler and operating method thereof |
| CN108303556B (en) * | 2018-01-10 | 2022-04-08 | 中南林业科技大学 | Medical intelligent biochemical detection system |
| CN109781609B (en) * | 2018-12-31 | 2021-05-28 | 苏州朗如精密机械科技有限公司 | Flow cytometry's offend protection formula sampler |
| CN109883895B (en) * | 2019-02-11 | 2023-09-05 | 辽宁科技大学 | Mixed particle layering test device and method |
| CN110079446B (en) * | 2019-02-28 | 2022-05-17 | 保定蕴生生物科技有限公司 | Fermentation tank for on-line monitoring of microbial fermentation products |
| CN111521547A (en) * | 2020-05-13 | 2020-08-11 | 洹仪科技(上海)有限公司 | Particle analyzing and sorting device and method |
| CN111796109B (en) * | 2020-07-13 | 2023-10-10 | 杭州道宇检测技术有限公司 | Automatic sample injection device of atomic absorption spectrophotometer |
| CN114350486A (en) * | 2020-10-13 | 2022-04-15 | 中国科学院大连化学物理研究所 | A spray needle interface arrangement for unicellular sample |
| CN117169535B (en) * | 2023-09-01 | 2024-02-27 | 俊兰(丽水)医院有限公司 | Sample adding device for medical examination |
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| CN201464484U (en) * | 2009-07-13 | 2010-05-12 | 天津市兰标电子科技发展有限公司 | Automatic sampling device for detection |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| DE19847759A1 (en) * | 1998-10-16 | 2000-04-20 | Dade Behring Marburg Gmbh | Interchangeable vibrating pipette needle |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN201464484U (en) * | 2009-07-13 | 2010-05-12 | 天津市兰标电子科技发展有限公司 | Automatic sampling device for detection |
| KR20130107146A (en) * | 2012-03-21 | 2013-10-01 | 주식회사 세라젬메디시스 | Measuring device and method |
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