CN104107260A - Pill for stopping bone hyperplasia - Google Patents
Pill for stopping bone hyperplasia Download PDFInfo
- Publication number
- CN104107260A CN104107260A CN201310137740.5A CN201310137740A CN104107260A CN 104107260 A CN104107260 A CN 104107260A CN 201310137740 A CN201310137740 A CN 201310137740A CN 104107260 A CN104107260 A CN 104107260A
- Authority
- CN
- China
- Prior art keywords
- parts
- pill
- medicine
- pharmaceutical composition
- joint
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to a pill for stopping bone hyperplasia. The pill is a medicine for treating hyperosteogeny and joint hypertrophy, concretely is a Chinese patent medicine prepared by taking Chinese herbal medicines as raw materials, and is capable of treating hyperosteogeny, joint hypertrophy and osteoarthritis caused by joint hypertrophy. The invention also relates to a preparation method of the medicine. The pill is an oral small honey pill prepared by taking radix rehmanniae preparata, herba cistanches, deerhorn glue, radix ginseng rubra (removing stem basal part), donkey-hide glue, caulis spatholobi, herba epimedii (processed), rhizoma drynariae (processed) and semen raphani as bulk drugs and performing screening, drying and crushing on the raw materials through a provided pill preparation technology. The provided formula is definite in therapeutic effect, and the pill is an ideal medicine capable of rapidly treating hyperosteogeny, joint hypertrophy and osteoarthritis caused by joint hypertrophy. The pill is simple in preparation method, easy to process and easy for large-scale production.
Description
Technical field
The present invention relates to one and treat hyperosteogeny, the pharmaceutical composition of joint hypertrophy, relates in particular to a kind for the treatment of hyperosteogeny taking Chinese herbal medicine as crude drug, Chinese medicine composition of joint hypertrophy and preparation method thereof.
Background technology
Osteoarthritis has hyperosteogeny, is joint degenerative change, but 80% above hyperostosis survivor is without clinical symptoms.The etiology and pathogenesis of osteoarthritis is more complicated, discusses confused altar, does not have unified opinion, proves that from clinical data this disease is mainly in more than 50 years old patient.Motherland's medical science is attributed to primary disease the category of " rheumatism involving the bone "." Lingshu Jing, Miraculous Pivot " thought: " evil at kidney, sick bone is clear ".Because this patient is mostly middle-aged and elderly people, QI and blood is gradually lost, deficiency of the liver and kindey, yang-energy degradation.Governor vessel inanition.YANG QI deficiency is weakened defensive QI, and wind, cold, wet heresy is taken advantage of a weak point, or strain for a long time, the body fluid deficiency of suffering from a deficiency of the kidney, and muscle arteries and veins loses supports.Affection of exogenous wind-cold damp, blocks grain, deficiency of both the liver and kidney of a specified duration, and venation is become estranged.Evil resistance joint, stagnation of QI-blood.Primary disease, taking pain as main, shows as deficiency in origin and excess in superficiality.Treatment is worked as with kidney-replenishing blood-nourishing, bone and muscle strengthening, blood-activating and qi-promoting, relaxing muscles and tendons and activating QI and blood in the collateral.This medicine is taking Radix Rehmanniae Preparata as monarch drug, and nourishing YIN is nourished blood, sperm adding and marrow healthing, and Radix Ginseng Rubra qi-supplementing, blood-engendering promotes the production of body fluid, and Colla cornus cervi, the Colla Corii Asini tonifying YIN of all enriching blood is supporing yang, is ministerial drug altogether.With Rhizoma Drynariae, Herba Cistanches, Herba Epimedii is supporing yang with muscle reinforcing and bone strengthening, enrich blood promoting the circulation of blood, relaxing muscles and tendons and activating QI and blood in the collateral, promoting blood circulation and stopping pain, eliminating blood stasis to promote regeneration of blood, row of Caulis Spatholobi is stagnant anti-greasy, is adjuvant drug altogether.The spleen and stomach provide the material basis of the acquired, source of generating QI and blood, and Semen Raphani is for making medicine, and with sending down the abnormal ascending QI machine aided taste, the biochemical vigorous kidney qi of QI and blood is sufficient.This medicine is medicine pill, nonirritant, and benefiting qi and nourishing blood, tonifying YIN is supporing yang, kidney and spleen invigorating.The stasis of blood is gone newborn, and the pain of invigorating blood circulation is stopped.Whole body is adjusted and is mended, and focuses on Bu Shen Zhuang muscle.Long-term taking, without obvious toxic-side effects, is applicable to the empty patient of old body especially.
Summary of the invention
The present invention brings into play Chinese medicine in treatment and prevention of osteoporosis hypertrophy, and the advantage of joint hypertrophy provides a kind of evident in efficacy, with low cost, treatment hyperosteogeny that toxic and side effects is little, the pharmaceutical composition of joint hypertrophy.
technology realizes approach
The present invention is that one is treated hyperosteogeny, and the pharmaceutical composition of joint hypertrophy is mainly made up of the component of following weight portion:
91.9 parts of Radix Rehmanniae Preparata 91.9 parts of Herba Cistanches, 20.4 parts of Radix Ginseng Rubra of 91.9 parts of Colla cornus cervis (going reed)
91.9 parts of 91.9 parts of Rhizoma Drynariae of Colla Corii Asini 91.9 parts of Herba Epimedii of 20.4 portions of Caulis Spatholobis (system) (system)
91.9 parts of Semen Raphanis
Pharmaceutical composition of the present invention is based on Chinese medicine hyperosteogeny, the loose differential diagnosis of diseases in joint and the dialectical principle that combines, treating both the principal and secondary aspects of a disease, deficiency and excess is also controlled, reinforce insufficiency and reduce excessiveness, and our negative and positive of qi and blood is with mending, be aided with the product of circulation of qi promoting, according to theory of Chinese medical science prescription, be prepared from according to certain weight proportion.
Pharmaceutical composition of the present invention, through dry, pulverize into fine powder, sieves, and mixes.Every 100g powder adds refined honey 67～77g and makes small honey pill, to obtain final product.
The present invention's herbal raw material used all therefrom pharmaceuticals buy, it meets national medical standard.
usage and consumption
Oral.4g(approximately 22 balls), 2 times on the one, child is cut down according to the circumstance, or follows the doctor's advice.
Detailed description of the invention
Further describe by the following examples the present invention, it should be understood that these embodiment, only for the object of illustration, never limit the scope of the invention.
The preparation of [embodiment 1] tablet, takes each raw material by following weight:
Radix Rehmanniae Preparata 91.9 g Herba Cistanches 91.9 g Colla cornus cervi 20.4 g Radix Ginseng Rubra (going reed) 91.9 g
Colla Corii Asini 20.4 g Caulis Spatholobi 91.9 g Herba Epimedii (system) 91.9 g Rhizoma Drynariae (system) 91.9 g
Semen Raphani 91.9 g
By the pharmaceutical composition of above-mentioned weight, through super-dry, pulverizing, fine powder is crossed 100 mesh sieves, obtains medicated powder, put into medicated powder with 50% ethanol, stir, cross 14 mesh sieve granulations, dry by 50～60 DEG C, add 1% magnesium stearate, by 12 mesh sieves, granulate, uses tablet machine tabletting, coating, press mold, subpackage are made tablet.
The preparation of [embodiment 2] powder takes each raw material by following weight:
Radix Rehmanniae Preparata 91.9 g Herba Cistanches 91.9 g Colla cornus cervi 20.4 g Radix Ginseng Rubra (going reed) 91.9 g
Colla Corii Asini 20.4 g Caulis Spatholobi 91.9 g Herba Epimedii (system) 91.9 g Rhizoma Drynariae (system) 91.9 g
Semen Raphani 91.9 g
Each above-mentioned weight raw material is mixed, pulverize by after 200 mesh sieves, sieve, mix, play granule, granulate, subpackage, make powder.
The preparation of [embodiment 3] small honey pill, takes each raw material by following weight:
Radix Rehmanniae Preparata 91.9 g Herba Cistanches 91.9 g Colla cornus cervi 20.4 g Radix Ginseng Rubra (going reed) 91.9 g
Colla Corii Asini 20.4 g Caulis Spatholobi 91.9 g Herba Epimedii (system) 91.9 g Rhizoma Drynariae (system) 91.9 g
Semen Raphani 91.9 g
Each above-mentioned weight raw material is mixed, pulverized after 120 mesh sieves, add the Mel of having refined by 1:0.72, close and stick together, pill, selects ball, and subpackage is made small honey pill.
[test example]medicine composite for curing hyperosteogeny of the present invention, the clinical observation on the therapeutic effect test of joint hypertrophy.
One, the physical data of subjects: this is organized in 386 examples, male 198 examples, female's 188 examples, morbidity half a year above person's 214 examples, more than 2 years person 138 examples, more than 10 years person 34 examples, clinical taking joint portion dull pain as main person's 320 examples, lumbago is mixed sciatic nerve radiating pain person 52 examples, gonalgia person 336 examples.300 routine patients all confirm there is hyperosteogeny through X-ray film, and more typical clinical symptoms.Wherein 8 examples are done NMR (Nuclear Magnetic Resonance)-imaging development; 36 examples are through CT examination.
Two, Therapeutic Method:
1 composition:
Radix Rehmanniae Preparata 91.9 g Herba Cistanches 91.9 g Colla cornus cervi 20.4 g Radix Ginseng Rubra (going reed) 91.9 g
Colla Corii Asini 20.4 g Caulis Spatholobi 91.9 g Herba Epimedii (system) 91.9 g Rhizoma Drynariae (system) 91.9 g
Semen Raphani 91.9 g
2, usage:, each 4 grams, every day 2 times.It within one month, is a course for the treatment of.After continuous 3 courses for the treatment of, judge curative effect.Period in a medicine, reduces and bears a heavy burden, appropriate exercise.
Three, efficacy assessment standard:
1. clinical cure: clinical symptom disappearance, it is normal that functional activity recovers, and can be engaged in former work.
2. effective: clinical symptoms is most of to disappear, and functional activity is normal, can be engaged in light muscle power work.
3. progressive: clinical symptom relief, funtion part is recovered, and can be engaged in light work or part-time employment, part-time job, part-time work.
4. invalid: as before, functional activity does not recover symptom.
Four, model case:
1, Liu X, female, 46 years old, people from Dadong District, Shenyang City.Waist and the right gonalgia more than 1 year, limitation of activity half a year, the state of an illness increases the weight of gradually, night sharp ache, take antibiotic medicine, analgesic drug product, starts slightly to alleviate, rear invalid, walk, defecation difficulty, x-ray film making is shown: lumbar vertebra hyperosteogeny generates, physiological curve disappears, and right knee space slightly narrows, 14 boxes of taking medicine altogether, 50 days courses for the treatment of, be equipped with acupuncture, transference cure, functional rehabilitation is normal, can be engaged in former work, follows up a case by regular visits to so far recurrence not yet.
2, Lee X X man people from Tiexi District of 42 years old Shenyang City.Cervical region while being admitted to hospital, left upper extremity paralysis, limitation of activity 1 year.Doctor advised acupuncture, massage physical therapy, coordinate and take Zhigu Zengshen pill, taking medicine after one week, and symptom is obviously improved.Left upper extremity feeling of numbness disappears, and brachial plexus nerve distraction test feminine gender, took medicine after one month, and cervical region is movable normal.
3, people from Tiexi District of 53 years old Shenyang City of chaste tree X X female.Cervical region while being admitted to hospital, left and right upper limb paralysis, limitation of activity 3 years.Doctor advised acupuncture, massage physical therapy, coordinate and take Zhigu Zengshen pill, taking medicine after one week, and symptom is obviously improved.Right upper extremity feeling of numbness disappears, brachial plexus nerve distraction test feminine gender.Take medicine after two months, cervical region is movable normal, and left upper extremity feeling of numbness disappears, brachial plexus nerve distraction test feminine gender.
4, people from Tiexi District of 50 years old Shenyang City of king X X female.Cervical region while being admitted to hospital, right upper extremity paralysis, limitation of activity 1 year.Doctor advised acupuncture, massage physical therapy, coordinate and take Zhigu Zengshen pill, taking medicine after 10 days, and symptom is obviously improved.Right upper extremity feeling of numbness disappears, brachial plexus nerve distraction test feminine gender.Take medicine after one month, cervical region is movable normal.
5, in the X X man Wensheng District people of 60 years old Liaoyang City.Cervical region while being admitted to hospital, left upper extremity paralysis, limitation of activity 2 years.Doctor advised acupuncture, massage physical therapy, coordinate and take Zhigu Zengshen pill, taking medicine after one week, and symptom is obviously improved.Left upper extremity feeling of numbness disappears, brachial plexus nerve distraction test feminine gender.Take medicine after two months, cervical region is movable normal.
6, people from peace zone of 41 years old Shenyang City of Liu X X female.Right upper extremity paralysis, limitation of activity 2 years.Doctor advised acupuncture, massage physical therapy, coordinate and take Zhigu Zengshen pill, taking medicine after one week, and symptom is obviously improved.Right upper extremity feeling of numbness disappears, brachial plexus nerve distraction test feminine gender.
7, Zhao X man peace zone X X of 46 years old Shenyang City.Left upper extremity paralysis while being admitted to hospital, limitation of activity 3 years.Doctor advised acupuncture, massage physical therapy, coordinate and take Zhigu Zengshen pill, taking medicine after one week, and symptom is obviously improved.Left upper extremity feeling of numbness disappears, brachial plexus nerve distraction test feminine gender.
8, Wu X X man people from Shenhe District of 55 years old Shenyang City.Cervical region paralysis while being admitted to hospital, limitation of activity 2 years.Doctor advised acupuncture, massage physical therapy, coordinate and take Zhigu Zengshen pill, taking medicine after one week, and symptom is obviously improved.Take medicine after one month, cervical region is movable normal.
9, king X man 46 years old: people from Shenhe District, Shenyang City.Cervical region while being admitted to hospital, right upper extremity paralysis, limitation of activity 1 year.Doctor advised acupuncture, massage physical therapy, coordinate and take Zhigu Zengshen pill, taking medicine after one week, and symptom is obviously improved.Right upper extremity feeling of numbness disappears, brachial plexus nerve distraction test feminine gender.Take medicine after one month, cervical region is movable normal.
10, Korea Spro X X man people from peace zone of 48 years old Shenyang City.Cervical region while being admitted to hospital, right upper extremity paralysis, limitation of activity 3 years.Doctor advised acupuncture, massage physical therapy, coordinate and take Zhigu Zengshen pill, taking medicine after one week, and symptom is obviously improved.Right upper extremity feeling of numbness disappears, brachial plexus nerve distraction test feminine gender.Take medicine after one month, cervical region is movable normal.
Five, therapeutic effect:
1. short term effect: clinical cure 300 examples, account for 77.72%, the shortest 7 days of the course for the treatment of, the longest 90 days.
2. long-term effect: we follow up a case by regular visits to for patient's tracking of nearly 3 years and judge late result.After 1 year, follow up a case by regular visits to 165 examples, recurrence 6 examples; After a year and a half, follow up a case by regular visits to 84 examples, recurrence 10 examples; After 2 years, follow up a case by regular visits to 46 examples, recurrence 2 examples.
Claims (6)
1. be used for the treatment of for a hyperosteogeny, the pharmaceutical composition of joint hypertrophy, is characterized in that being made up of the crude drug of following weight portion:
2～36 parts of Radix Rehmanniae Preparata 2～36 parts of Herba Cistanches, 2～8 parts of Radix Ginseng Rubra of 2～36 parts of Colla cornus cervis (going reed)
2～36 parts of 2～36 parts of Semen Raphanis of 2～36 parts of Rhizoma Drynariae of Colla Corii Asini 2～36 parts of Herba Epimedii of 2～8 portions of Caulis Spatholobis (system) (system).
2. according to pharmaceutical composition claimed in claim 1, it is characterized in that: the weight portion of each crude drug is:
2～18 parts of Radix Rehmanniae Preparata 2～18 parts of Herba Cistanches, 2～4 parts of Radix Ginseng Rubra of 2～18 parts of Colla cornus cervis (going reed)
2～18 parts of 2～18 parts of Semen Raphanis of 2～18 parts of Rhizoma Drynariae of Colla Corii Asini 2～18 parts of Herba Epimedii of 2～4 portions of Caulis Spatholobis (system) (system).
3. according to pharmaceutical composition claimed in claim 3, wherein the weight portion of each component is:
91.9 parts of Radix Rehmanniae Preparata 91.9 parts of Herba Cistanches, 20.4 parts of Radix Ginseng Rubra of 91.9 parts of Colla cornus cervis (going reed)
91.9 parts of 91.9 parts of Rhizoma Drynariae of Colla Corii Asini 91.9 parts of Herba Epimedii of 20.4 portions of Caulis Spatholobis (system) (system)
91.9 parts of Semen Raphanis.
4. according to any one pharmaceutical composition described in claim 1,2,3, it is characterized in that: can method of Chinese medicinal routinely be prepared into any conventional oral formulations.
5. according to pharmaceutical composition claimed in claim 4, it is characterized in that: described oral formulations is pill, capsule, tablet, powder or granule.
6. the arbitrary pharmaceutical composition described in claim 1～5 treats in preparation the kidney tonifying that nourishes blood, strengthening the tendons and bones, and for hyperosteogeny, the application in the hypertrophy of joint.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310137740.5A CN104107260A (en) | 2013-04-20 | 2013-04-20 | Pill for stopping bone hyperplasia |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310137740.5A CN104107260A (en) | 2013-04-20 | 2013-04-20 | Pill for stopping bone hyperplasia |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104107260A true CN104107260A (en) | 2014-10-22 |
Family
ID=51704379
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310137740.5A Pending CN104107260A (en) | 2013-04-20 | 2013-04-20 | Pill for stopping bone hyperplasia |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104107260A (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1375320A (en) * | 2002-04-01 | 2002-10-23 | 徐瑞新 | Chinese medicine for treating hyperosteogeny and its prepn. |
| KR20070056207A (en) * | 2005-11-29 | 2007-06-04 | 주식회사 엘지생활건강 | Testosterone 5alpha-reductase inhibitor containing vitis radix extract |
-
2013
- 2013-04-20 CN CN201310137740.5A patent/CN104107260A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1375320A (en) * | 2002-04-01 | 2002-10-23 | 徐瑞新 | Chinese medicine for treating hyperosteogeny and its prepn. |
| KR20070056207A (en) * | 2005-11-29 | 2007-06-04 | 주식회사 엘지생활건강 | Testosterone 5alpha-reductase inhibitor containing vitis radix extract |
Non-Patent Citations (1)
| Title |
|---|
| 张妉: "中药内服外用治疗骨性关节炎380例疗效观察", 《中华中医药学刊》, vol. 26, no. 2, 29 February 2008 (2008-02-29) * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101181453B (en) | Chinese medicine preparation for curing orthopaedics sickness | |
| CN100394955C (en) | Chinese traditional medicine preparation for treating bone fracture and traumatic injury | |
| CN101549137A (en) | Chinese medicine preparation for treating bone joint disease | |
| CN103565969B (en) | Traditional Chinese medicine composition for treating soft tissue injury and fracture | |
| CN104000993A (en) | Pills with effects of strengthening bones and stretching muscles and tendons and preparation technology thereof | |
| CN102920987B (en) | Acupuncture point soft body wax moxibustion medicine for external application and manufacture and external application methods thereof | |
| CN102091169B (en) | Traditional Chinese medicine capsule capable of tonifying liver and kidney, promoting blood circulation by removing blood stasis, dispelling wind, cold and dampness | |
| CN101912536A (en) | Medicinal composition for treating rheumatism and rheumatoid disease | |
| CN104107288A (en) | Sinew-relaxing collateral-activating pill | |
| CN1083377A (en) | Yaojingkang (drug for curing lumbar and cervical diseases) | |
| CN101904958B (en) | Oral medicinal composition for treating fracture | |
| CN100546597C (en) | A kind of Chinese medicine for the treatment of hyperosteogeny, rheumatic and rheumatoid arthritis and sciatica | |
| CN103861004A (en) | Traditional Chinese medicine external application agent for treating knee osteoarthritis and nursing method | |
| CN101530522B (en) | Chinese medicine preparation for treating wind-cold-dampness pains | |
| CN102552843B (en) | Medicament composite for curing osteoarthropathy | |
| CN101810747B (en) | Chinese medicinal preparation for treating cervical spondylosis and lumbar disc herniation | |
| CN103989968A (en) | Oral traditional Chinese medicinal composition for treating cervical spinal stenosis | |
| CN104107260A (en) | Pill for stopping bone hyperplasia | |
| CN102872287A (en) | Traditional Chinese medicine composition for treating femoral head necrosis and preparation method thereof | |
| CN102920887A (en) | Chinese medicinal composition for treating hyperostosis | |
| CN102283942A (en) | Orally-administrated Chinese medicinal preparation for treating ankylosing spondlitis | |
| CN103083489B (en) | Traditional Chinese medicine wine for treating lumbar spondylosis, cervical spondylosis, early osteoproliferation and old wounds | |
| CN102836346B (en) | Traditional Chinese medicine for treating lumbar disc herniation | |
| CN101954043A (en) | Medicament for treating hyperosteogeny and preparation method thereof | |
| CN101897857A (en) | Traditional Chinese medicine pill for curing lumbago |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20141022 |