CN104095859A - 闭花木酮Cleistanone的O-(哌啶基)乙基衍生物在制备抗肝纤维化药物中的应用 - Google Patents
闭花木酮Cleistanone的O-(哌啶基)乙基衍生物在制备抗肝纤维化药物中的应用 Download PDFInfo
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- CN104095859A CN104095859A CN201410374731.2A CN201410374731A CN104095859A CN 104095859 A CN104095859 A CN 104095859A CN 201410374731 A CN201410374731 A CN 201410374731A CN 104095859 A CN104095859 A CN 104095859A
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- cleistanone
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- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 title claims abstract description 44
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- GEIFQLXIDUDMNZ-PCJVTFPHSA-N (4aR,4bR,6aR,8S,10aR,10bR,12R,12aR)-12-hydroxy-1,1,1',1',4a,10a,10b-heptamethyl-3'-methylidenespiro[3,4,4b,5,6,6a,7,9,10,11,12,12a-dodecahydrochrysene-8,2'-cyclopentane]-2-one Chemical compound CC1(C)CCC(=C)[C@@]11C[C@@H](CC[C@H]2[C@]3(C[C@@H](O)[C@H]4C(C)(C)C(=O)CC[C@@]42C)C)[C@@]3(C)CC1 GEIFQLXIDUDMNZ-PCJVTFPHSA-N 0.000 claims abstract description 45
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Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104447938A (zh) * | 2014-11-05 | 2015-03-25 | 南京大学 | 闭花木酮的o-(哌嗪基)乙基衍生物、制备方法及其用途 |
CN104758298A (zh) * | 2015-04-15 | 2015-07-08 | 南京大学 | 闭花木酮的o-(1h-四氮唑基)乙基衍生物在制备治疗或预防肾纤维化药物中的应用 |
CN104784175A (zh) * | 2015-05-12 | 2015-07-22 | 南京大学 | Daphmalenine A衍生物在制备升高白细胞的药物中的应用 |
CN104840471A (zh) * | 2015-04-15 | 2015-08-19 | 南京广康协生物医药技术有限公司 | 闭花木酮的o-(1h-四氮唑基)乙基衍生物在制备抗肝纤维化药物中的应用 |
CN104922120A (zh) * | 2015-05-27 | 2015-09-23 | 南京广康协生物医药技术有限公司 | Daphmalenine A的O-(二乙胺基)乙基衍生物在制备抗肝纤维化药物中的应用 |
CN104922121A (zh) * | 2015-05-27 | 2015-09-23 | 南京广康协生物医药技术有限公司 | Daphmalenine A的O-(二乙胺基)乙基衍生物在制备升高白细胞的药物中的应用 |
CN104922122A (zh) * | 2015-05-27 | 2015-09-23 | 南京广康协生物医药技术有限公司 | Daphmalenine A的O-(二乙胺基)乙基衍生物在制备预防或治疗胰腺纤维化药物中的应用 |
CN110538177A (zh) * | 2017-09-13 | 2019-12-06 | 北京理工大学 | 一种芳基萘类木脂素类化合物在制备抗肝纤维化药物中的应用 |
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2014
- 2014-07-31 CN CN201410374731.2A patent/CN104095859B/zh active Active
Non-Patent Citations (2)
Title |
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VAN TRINH THI THANH, ET AL.: "Cleistanone: A Triterpenoid from Cleistanthus indochinensis with a New Carbon Skeleton", 《EUR. J. ORG. CHEM.》, 7 June 2011 (2011-06-07), pages 4108 - 4111 * |
罗奕 等: "齐墩果酸对四氯化碳所致大鼠肝纤维损伤的保护作用", 《中国药师》, vol. 17, no. 3, 5 March 2014 (2014-03-05), pages 378 - 381 * |
Cited By (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104447938A (zh) * | 2014-11-05 | 2015-03-25 | 南京大学 | 闭花木酮的o-(哌嗪基)乙基衍生物、制备方法及其用途 |
CN104447938B (zh) * | 2014-11-05 | 2016-11-30 | 南京大学 | 闭花木酮的o-(哌嗪基)乙基衍生物、制备方法及其用途 |
CN104758298A (zh) * | 2015-04-15 | 2015-07-08 | 南京大学 | 闭花木酮的o-(1h-四氮唑基)乙基衍生物在制备治疗或预防肾纤维化药物中的应用 |
CN104840471A (zh) * | 2015-04-15 | 2015-08-19 | 南京广康协生物医药技术有限公司 | 闭花木酮的o-(1h-四氮唑基)乙基衍生物在制备抗肝纤维化药物中的应用 |
CN104784175A (zh) * | 2015-05-12 | 2015-07-22 | 南京大学 | Daphmalenine A衍生物在制备升高白细胞的药物中的应用 |
CN104922120A (zh) * | 2015-05-27 | 2015-09-23 | 南京广康协生物医药技术有限公司 | Daphmalenine A的O-(二乙胺基)乙基衍生物在制备抗肝纤维化药物中的应用 |
CN104922121A (zh) * | 2015-05-27 | 2015-09-23 | 南京广康协生物医药技术有限公司 | Daphmalenine A的O-(二乙胺基)乙基衍生物在制备升高白细胞的药物中的应用 |
CN104922122A (zh) * | 2015-05-27 | 2015-09-23 | 南京广康协生物医药技术有限公司 | Daphmalenine A的O-(二乙胺基)乙基衍生物在制备预防或治疗胰腺纤维化药物中的应用 |
CN110538177A (zh) * | 2017-09-13 | 2019-12-06 | 北京理工大学 | 一种芳基萘类木脂素类化合物在制备抗肝纤维化药物中的应用 |
CN110538176A (zh) * | 2017-09-13 | 2019-12-06 | 北京理工大学 | 芳基萘类木脂素类化合物在制备抗肝纤维化药物中的应用 |
CN110538176B (zh) * | 2017-09-13 | 2022-08-02 | 北京理工大学 | 芳基萘类木脂素类化合物在制备抗肝纤维化药物中的应用 |
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