CN104086501A - 一种par-1拮抗剂、其制备方法和用途 - Google Patents
一种par-1拮抗剂、其制备方法和用途 Download PDFInfo
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- CN104086501A CN104086501A CN201410352032.8A CN201410352032A CN104086501A CN 104086501 A CN104086501 A CN 104086501A CN 201410352032 A CN201410352032 A CN 201410352032A CN 104086501 A CN104086501 A CN 104086501A
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- 0 CC(C)(C)c(cc(cc1N2CCOCC2)C(CN2NC(c3ccccc3)N=CC*2)=O)c1OC Chemical compound CC(C)(C)c(cc(cc1N2CCOCC2)C(CN2NC(c3ccccc3)N=CC*2)=O)c1OC 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
样品 | 血小板凝聚的抑制 IC50 (nM) |
化合物I | 2.7 |
Claims (6)
Priority Applications (1)
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CN201410352032.8A CN104086501B (zh) | 2014-07-23 | 2014-07-23 | 一种par-1拮抗剂、其制备方法和用途 |
Applications Claiming Priority (1)
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CN201410352032.8A CN104086501B (zh) | 2014-07-23 | 2014-07-23 | 一种par-1拮抗剂、其制备方法和用途 |
Publications (2)
Publication Number | Publication Date |
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CN104086501A true CN104086501A (zh) | 2014-10-08 |
CN104086501B CN104086501B (zh) | 2016-02-17 |
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CN201410352032.8A Expired - Fee Related CN104086501B (zh) | 2014-07-23 | 2014-07-23 | 一种par-1拮抗剂、其制备方法和用途 |
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CN (1) | CN104086501B (zh) |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104496932A (zh) * | 2015-01-13 | 2015-04-08 | 佛山市赛维斯医药科技有限公司 | 一类含胺基对位取代苯的恶二唑亚砜化合物、其制备方法和用途 |
CN104496931A (zh) * | 2015-01-13 | 2015-04-08 | 佛山市赛维斯医药科技有限公司 | 含胺基取代苯的恶二唑亚砜化合物、其制备方法和用途 |
CN104513212A (zh) * | 2015-01-13 | 2015-04-15 | 佛山市赛维斯医药科技有限公司 | 一类含硝基苯的恶二唑亚砜化合物、其制备方法和用途 |
CN104529931A (zh) * | 2015-01-13 | 2015-04-22 | 佛山市赛维斯医药科技有限公司 | 一类含烷氧对位取代苯的恶二唑亚砜化合物、其制备方法和用途 |
CN104529927A (zh) * | 2015-01-13 | 2015-04-22 | 佛山市赛维斯医药科技有限公司 | 一类含卤代苯的恶二唑亚砜化合物、其制备方法和用途 |
CN104529928A (zh) * | 2015-01-13 | 2015-04-22 | 佛山市赛维斯医药科技有限公司 | 一类恶二唑亚砜化合物、其制备方法和用途 |
CN104529929A (zh) * | 2015-01-13 | 2015-04-22 | 佛山市赛维斯医药科技有限公司 | 含烷氧取代苯的恶二唑亚砜化合物、其制备方法和用途 |
CN104529930A (zh) * | 2015-01-13 | 2015-04-22 | 佛山市赛维斯医药科技有限公司 | 一类含腈基苯的恶二唑亚砜化合物、其制备方法和用途 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998057937A2 (en) * | 1997-06-19 | 1998-12-23 | The Du Pont Merck Pharmaceutical Company | Inhibitors of factor xa with a neutral p1 specificity group |
CN1503784A (zh) * | 2001-04-19 | 2004-06-09 | ������������ʽ���� | 2-亚氨基吡咯烷衍生物 |
US20040138309A1 (en) * | 2002-07-26 | 2004-07-15 | Boehringer Ingelheim | Novel substituted benzoic acid amides, their preparation and their use as pharmaceutical compositions |
CN1852710A (zh) * | 2003-07-15 | 2006-10-25 | 拜耳医药保健股份公司 | 用作治疗心血管疾病的par-1-拮抗剂的吡唑啉类化合物 |
-
2014
- 2014-07-23 CN CN201410352032.8A patent/CN104086501B/zh not_active Expired - Fee Related
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998057937A2 (en) * | 1997-06-19 | 1998-12-23 | The Du Pont Merck Pharmaceutical Company | Inhibitors of factor xa with a neutral p1 specificity group |
CN1503784A (zh) * | 2001-04-19 | 2004-06-09 | ������������ʽ���� | 2-亚氨基吡咯烷衍生物 |
US20040138309A1 (en) * | 2002-07-26 | 2004-07-15 | Boehringer Ingelheim | Novel substituted benzoic acid amides, their preparation and their use as pharmaceutical compositions |
CN1852710A (zh) * | 2003-07-15 | 2006-10-25 | 拜耳医药保健股份公司 | 用作治疗心血管疾病的par-1-拮抗剂的吡唑啉类化合物 |
Non-Patent Citations (2)
Title |
---|
SAMUEL CHACKALAMANNIL: "Thrombin Receptor (Protease Activated Receptor-1) Antagonists as Potent Antithrombotic Agents with Strong Antiplatelet Effects", 《JOURNAL OF MEDICINAL CHEMISTRY》, vol. 49, no. 18, 31 August 2006 (2006-08-31), pages 5389 - 5403, XP002582198, DOI: doi:10.1021/jm0603670 * |
张林山: "PAR-1受体拮抗剂E5555类似物的合成研究", 《青岛科技大学硕士学位论文》, 15 June 2013 (2013-06-15), pages 29 - 33 * |
Cited By (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104496932A (zh) * | 2015-01-13 | 2015-04-08 | 佛山市赛维斯医药科技有限公司 | 一类含胺基对位取代苯的恶二唑亚砜化合物、其制备方法和用途 |
CN104496931A (zh) * | 2015-01-13 | 2015-04-08 | 佛山市赛维斯医药科技有限公司 | 含胺基取代苯的恶二唑亚砜化合物、其制备方法和用途 |
CN104513212A (zh) * | 2015-01-13 | 2015-04-15 | 佛山市赛维斯医药科技有限公司 | 一类含硝基苯的恶二唑亚砜化合物、其制备方法和用途 |
CN104529931A (zh) * | 2015-01-13 | 2015-04-22 | 佛山市赛维斯医药科技有限公司 | 一类含烷氧对位取代苯的恶二唑亚砜化合物、其制备方法和用途 |
CN104529927A (zh) * | 2015-01-13 | 2015-04-22 | 佛山市赛维斯医药科技有限公司 | 一类含卤代苯的恶二唑亚砜化合物、其制备方法和用途 |
CN104529928A (zh) * | 2015-01-13 | 2015-04-22 | 佛山市赛维斯医药科技有限公司 | 一类恶二唑亚砜化合物、其制备方法和用途 |
CN104529929A (zh) * | 2015-01-13 | 2015-04-22 | 佛山市赛维斯医药科技有限公司 | 含烷氧取代苯的恶二唑亚砜化合物、其制备方法和用途 |
CN104529930A (zh) * | 2015-01-13 | 2015-04-22 | 佛山市赛维斯医药科技有限公司 | 一类含腈基苯的恶二唑亚砜化合物、其制备方法和用途 |
CN104529930B (zh) * | 2015-01-13 | 2016-03-09 | 佛山市赛维斯医药科技有限公司 | 一类含腈基苯的噁二唑亚砜化合物、其制备方法和用途 |
CN104513212B (zh) * | 2015-01-13 | 2016-03-09 | 佛山市赛维斯医药科技有限公司 | 一类含硝基苯的恶二唑亚砜化合物、其制备方法和用途 |
CN104529927B (zh) * | 2015-01-13 | 2016-04-06 | 佛山市赛维斯医药科技有限公司 | 一类含卤代苯的恶二唑亚砜化合物、其制备方法和用途 |
CN104529931B (zh) * | 2015-01-13 | 2016-04-06 | 佛山市赛维斯医药科技有限公司 | 一类含烷氧对位取代苯的恶二唑亚砜化合物、其制备方法和用途 |
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Publication number | Publication date |
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CN104086501B (zh) | 2016-02-17 |
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Effective date of registration: 20180918 Address after: 273509 No. 883, Cheng Qian village, Cheng Qian Town, Zoucheng City, Jining, Shandong. Patentee after: Wang Jia Address before: 230000 Anhui Hefei hi tech Zone Innovation Industrial Park two phase J2 block C 1801 Patentee before: HEFEI WISDOM LONGTUTENG INTELLECTUAL PROPERTY CO., LTD. |
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