CN104086500A - 一种par-1拮抗剂及其用途 - Google Patents
一种par-1拮抗剂及其用途 Download PDFInfo
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- CN104086500A CN104086500A CN201410351972.5A CN201410351972A CN104086500A CN 104086500 A CN104086500 A CN 104086500A CN 201410351972 A CN201410351972 A CN 201410351972A CN 104086500 A CN104086500 A CN 104086500A
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- compound
- par
- antagonist
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Description
样品 | 血小板凝聚的抑制 IC50 (nM) |
化合物I | 1.9 |
Claims (3)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN201410351972.5A CN104086500B (zh) | 2014-07-23 | 2014-07-23 | 一种par-1拮抗剂及其用途 |
Applications Claiming Priority (1)
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CN201410351972.5A CN104086500B (zh) | 2014-07-23 | 2014-07-23 | 一种par-1拮抗剂及其用途 |
Publications (2)
Publication Number | Publication Date |
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CN104086500A true CN104086500A (zh) | 2014-10-08 |
CN104086500B CN104086500B (zh) | 2015-08-26 |
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CN201410351972.5A Active CN104086500B (zh) | 2014-07-23 | 2014-07-23 | 一种par-1拮抗剂及其用途 |
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CN (1) | CN104086500B (zh) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104529923A (zh) * | 2015-01-13 | 2015-04-22 | 佛山市赛维斯医药科技有限公司 | 二烯四氮唑硝基苯类化合物、其制备方法和用途 |
CN104529928A (zh) * | 2015-01-13 | 2015-04-22 | 佛山市赛维斯医药科技有限公司 | 一类恶二唑亚砜化合物、其制备方法和用途 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998057937A2 (en) * | 1997-06-19 | 1998-12-23 | The Du Pont Merck Pharmaceutical Company | Inhibitors of factor xa with a neutral p1 specificity group |
US20110105490A1 (en) * | 2009-10-29 | 2011-05-05 | Han-Cheng Zhang | 2,3-dihydro-1h-isoindol-1-imine derivatives useful as thrombin par-1 receptor antagonist |
CN102241621A (zh) * | 2010-05-11 | 2011-11-16 | 江苏恒瑞医药股份有限公司 | 5,5-双取代-2-亚氨基吡咯烷类衍生物、其制备方法及其在医药上的应用 |
-
2014
- 2014-07-23 CN CN201410351972.5A patent/CN104086500B/zh active Active
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998057937A2 (en) * | 1997-06-19 | 1998-12-23 | The Du Pont Merck Pharmaceutical Company | Inhibitors of factor xa with a neutral p1 specificity group |
US20110105490A1 (en) * | 2009-10-29 | 2011-05-05 | Han-Cheng Zhang | 2,3-dihydro-1h-isoindol-1-imine derivatives useful as thrombin par-1 receptor antagonist |
CN102241621A (zh) * | 2010-05-11 | 2011-11-16 | 江苏恒瑞医药股份有限公司 | 5,5-双取代-2-亚氨基吡咯烷类衍生物、其制备方法及其在医药上的应用 |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104529923A (zh) * | 2015-01-13 | 2015-04-22 | 佛山市赛维斯医药科技有限公司 | 二烯四氮唑硝基苯类化合物、其制备方法和用途 |
CN104529928A (zh) * | 2015-01-13 | 2015-04-22 | 佛山市赛维斯医药科技有限公司 | 一类恶二唑亚砜化合物、其制备方法和用途 |
Also Published As
Publication number | Publication date |
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CN104086500B (zh) | 2015-08-26 |
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Effective date of registration: 20170803 Address after: 510640 Guangdong City, Tianhe District Province, No. five, road, public education building, unit 371-1, unit 2401 Patentee after: Guangdong Gaohang Intellectual Property Operation Co., Ltd. Address before: 528000 Guangdong, Foshan District, Pu Lan Road, the first floor of the first floor, No. 5, Chancheng Patentee before: Zhang Yuanqiang |
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Effective date of registration: 20181128 Address after: 221300 room 103, student Pioneer Park, Pizhou, Xuzhou, Jiangsu Patentee after: Jiangsu Sannong Tesco Agel Ecommerce Ltd Address before: 510640 2401, unit 371-1, Zhong Gong education building, five mountain road, Tianhe District, Guangzhou, Guangdong. Patentee before: Guangdong Gaohang Intellectual Property Operation Co., Ltd. |
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Effective date of registration: 20190428 Address after: Room 801 and 803, Building D, 606 Ningliu Road, Changlu Street, Jiangbei New District, Nanjing City, Jiangsu Province, 210000 Patentee after: Nanjing Wangzhixing Pharmaceutical Technology Co., Ltd. Address before: 221300 room 103, student Pioneer Park, Pizhou, Xuzhou, Jiangsu Patentee before: Jiangsu Sannong Tesco Agel Ecommerce Ltd |