CN104083455B - For preventing or treating the composition of periodontosis, type teeth occlusion device and preparation method - Google Patents
For preventing or treating the composition of periodontosis, type teeth occlusion device and preparation method Download PDFInfo
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- CN104083455B CN104083455B CN201410292550.5A CN201410292550A CN104083455B CN 104083455 B CN104083455 B CN 104083455B CN 201410292550 A CN201410292550 A CN 201410292550A CN 104083455 B CN104083455 B CN 104083455B
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Abstract
The invention belongs to periodontosis prevention or treatment technology field, disclose a kind of composition for preventing or treat periodontosis, described composition is made up of Chinese medicine recombination chitosan/sodium alginate electrolyte sponge, and described composition includes: the Chinese herbal ultra-fine powder of 7.7wt%～11.8wt%；The shitosan of 29.4wt%～30.8wt%；The sodium alginate of 58.8wt%～61.5wt%.The invention also discloses a kind of for preventing or the type teeth occlusion device treating periodontosis and preparation method thereof.Technique scheme can solve the problem that current plug-in type oral cavity controls the side effect of preparation existence relatively greatly, the problem that Long-Time Service easy inducible resistance bacterial strain produces and causes flora imbalance.And, the type teeth occlusion device that the present invention provides is preferably arc strip or facing, it is possible to increase the simplicity of use.
Description
Technical field
The present invention relates to periodontosis prevention or treatment technology field, more specifically, relate to a kind of for preventing or treating
The composition of periodontosis, type teeth occlusion device and preparation method.
Background technology
Periodontosis is to occur at the disease of periodontium, the tooth of serious harm people and whole body health.For preventing or treating
The medicament of periodontosis or method have a variety of, including mouthwash, pulvis, Perorally administrable antimicrobial agent, traditional Chinese herbal decoction, operation on oral cavity
Deng.But above-mentioned medicament or method all have weak point.As mouthwash gulps down the most by mistake；What pulvis applied is limited in scope, nothing
Method nurses one's health whole oral cavity；The generation of Perorally administrable antimicrobial agent easy inducible resistance bacterial strain, and flora imbalance can be caused；Chinese medicinal decoction
Agent oral courses is longer, and specific aim is the strongest；Operation on oral cavity not only economic cost is too high, and patient suffering.
Current a kind of preparation is as follows: use medical grade sodium alginate as dosage form substrate, polyvinyl alcohol as adhesive,
Then compound have the MET of anaerobe resistant effect and have the non-steroidal anti-inflammatory drug pair of anti-inflammatory analgetic effect
Chlorine goes out bitterly, makes compound topical plug-in type oral cavity and controls preparation.This plug-in type oral cavity controls preparation to insert periodontal and hat week
The common active chronic inflammation of the department of stomatology such as periodontitis and pericoronitis is treated Deng the mode of diseased region.Above-mentioned plug-in type oral cavity controls
Preparation contains western medicine composition, causes its side effect bigger.And above-mentioned plug-in type oral cavity controls preparation and has anaerobe resistant and make
MET, this antibacterials of Long-Time Service easy inducible resistance bacterium produce and cause flora imbalance, unfavorable
Alleviation in periodontosis.
Use the mode inserted to carry out the treatment of periodontosis it addition, above-mentioned plug-in type oral cavity controls preparation, can cause operating relatively
For difficulty, and then simplicity that preparation is used is strong not and be only used for hospitalize.
Summary of the invention
The present invention provides a kind of for preventing or treating the composition of periodontosis, type teeth occlusion device and preparation method, to solve
The side effect that current plug-in type oral cavity controls preparation existence is relatively big, and easy inducible resistance bacterial strain produces and causes flora imbalance
Problem.
In order to solve above-mentioned technical problem, the present invention provides following technical scheme:
For preventing or treat the composition of periodontosis, described composition is by Chinese medicine recombination chitosan/sodium alginate electrolyte
Sponge is made, and described composition includes:
The Chinese herbal ultra-fine powder of 7.7wt%～11.8wt%；
The shitosan of 29.4wt%～30.8wt%；
The sodium alginate of 58.8wt%～61.5wt%.
Preferably, in above-mentioned composition, described Chinese herbal ultra-fine powder is composed of the following components:
Rhubarb 15 parts, prepared RADIX ET RHIZOMA RHEI 10 parts, gypsum 15 parts, the plaster of paris 10 parts, the rhizome of davallia 10 parts, filamentary silver is shut out
Secondary 10 parts, blue or green salt 15 parts, salt 15 parts, each 15 parts of alumen, Radix Angelicae Sinensis and the root of Dahurain angelica, the root of Chinese wild ginger 5 parts, flos caryophylli 10 parts,
The weight of above-mentioned every part is the most equal.
Preferably, in above-mentioned composition, described Chinese herbal ultra-fine powder is composed of the following components:
Cape jasmine 10 parts, the capsule of weeping forsythia 10 parts, peppermint 10 parts, the root of large-flowered skullcap 10 parts, 6 parts of the dried rhizome of rehmannia, 6 parts of Radix Glycyrrhizae, above-mentioned every part
Weight the most equal.
Preferably, in above-mentioned composition, described Chinese herbal ultra-fine powder is composed of the following components:
Eclipta prostrata 30 parts, blue or green salt 30 parts, fennel seeds 30 parts, the root of Dahurain angelica 30 parts, rattletop 15 parts, the root of Chinese wild ginger 15 parts, stone
Cream 60 parts, 9 parts of Chinese prickly ash, the weight of above-mentioned every part is the most equal.
For preventing or treat the type teeth occlusion device of periodontosis, described type teeth occlusion device is by any in the claims 1-4
One described composition is made.
Preferably, in above-mentioned type teeth occlusion device, described tooth capacity checking device be along teeth arrangement direction extend arc strip or
Facing.
For preventing or treat the type teeth occlusion device preparation method of periodontosis, comprise the following steps:
1) shitosan is dissolved in aqueous acetic acid, obtains chitosan solution；
2) chitosan solution is mixed with sodium alginate aqueous solution, obtain mixed solution；
3) Chinese herbal ultra-fine powder is dissolved in described mixed solution, is sufficiently stirred for reaching homogenate solution, described homogenate solution
Solute include the Chinese herbal ultra-fine powder of 7.7wt%～11.8wt%, the shitosan of 29.4wt%～30.8wt% and
The sodium alginate of 58.8wt%～61.5wt%；
4) by implementing freeze-drying for the first time in the mould of type teeth occlusion device described in described homogenate solution, described tooth is obtained
Occluder.
Preferably, in above-mentioned preparation method, step 4) also include afterwards:
By described type teeth occlusion device successively at CaCl2Wash with distilled water after NaOH solution is soaked；
Again the type teeth occlusion device after washing is implemented second time freeze-drying.
Preferably, in above-mentioned preparation method, described first time freeze-drying and second time cryodesiccated condition be: 12 DEG C～
25 DEG C, aseptic.
It is preferably, above-mentioned 9, according to the type teeth occlusion device described in any one in claim 5-8, it is characterised in that
Described tooth capacity checking device is the arc strip or facing extended along teeth arrangement direction.
For background technology, the composition being used for preventing or treating periodontosis of embodiment of the present invention offer does not exists
Western medicine composition, so side effect is less, and does not use antiseptic, will not the generation of inducible resistance bacterial strain and causing yet
The problem of flora imbalance.
Accompanying drawing explanation
For the technical scheme being illustrated more clearly that in the embodiment of the present invention, required use in embodiment being described below
Accompanying drawing be briefly described, it should be apparent that, for those of ordinary skills, do not paying creative labor
On the premise of Dong, it is also possible to obtain other accompanying drawing according to these accompanying drawings.
Fig. 1 is the type teeth occlusion device preparation method flow chart for preventing or treat periodontosis that the embodiment of the present invention provides.
Detailed description of the invention
Embodiments provide a kind of for preventing or treating the composition of periodontosis, type teeth occlusion device and making side
Method, solves current plug-in type oral cavity and controls the Western medicine side effect of preparation existence relatively greatly, and Long-Time Service antibiotic easily lures
Lead the problem that antibody-resistant bacterium produces and causes flora imbalance.
For the technical scheme making those skilled in the art be more fully understood that in the embodiment of the present invention, and the present invention is made to implement
The above-mentioned purpose of example, feature and advantage can become apparent from understandable, below in conjunction with the accompanying drawings to the technology in the embodiment of the present invention
Scheme is described in further detail.
Embodiments providing a kind of composition for preventing or treat periodontosis, described composition is multiple by Chinese medicine
Close shitosan/sodium alginate electrolyte sponge to make.The present embodiment provide composition include Chinese herbal ultra-fine powder, shitosan and
Sodium alginate.Wherein: Chinese herbal ultra-fine powder mass content is 7.7wt%～11.8wt%, chitosan mass content is
29.4wt%～30.8wt%, the mass content of sodium alginate is 58.8wt%～61.5wt%.
Shitosan has preferable antibacterial activity, can suppress the growth and breeding of some fungies, bacterium and virus.It is now recognized that
Its possible mechanism has be polycation due to shitosan at three: one, it is easy to the collection that fungal cell surface is electronegative
Group's effect, thus change mobility and the permeability of pathogen cell membrane；Two is to disturb DNA replication dna and transcribe；Three is resistance
Disconnected pathogen metabolism.
Sodium alginate has another name called brown alga Yoghourt, seaweed gel, algin, alginates, and sodium alginate is by the sky extracted in sea-tangle
So polysaccharide carbohydrate.Nontoxic, be used for medical industry, be dissolved in water, there is hydrophily strong, flexibility, homogeneity,
Stability and other good characteristics.
Chinese herbal ultra-fine powder refers to use Study on Supermicro-pulverization of Traditional Chinese Drugs technology that the prepared slices of Chinese crude drugs are ground into the ultra micro that particle diameter is 1-10 μm
Powder so that medicinal material plant cell wall breaking rate improves, the beneficially dissolution of effective ingredient, increases the specific surface area of medicine, makes
Its absorption rate and uptake increase.It should be noted that the Chinese herbal ultra-fine powder in the embodiment of the present invention refers to beneficially
Prevention or some traditional Chinese medicine ingredients for the treatment of periodontosis, such as anti-inflammatory medicine material.The traditional Chinese medical science think periodontosis belong to pingival atrophy, tooth very,
Tooth shakes, tooth and gap category.The Etiological causing periodontosis includes stomach and intestine accumulated heat, deficient qi and blood, the loss of kidney source, oral cavity
Unclean etc..And kidney is main bone, tooth being the surplus of the bone, so raping of tooth is closely related with congenital kidney.From theory of traditional Chinese medical science
Setting out, in order to reach to take care of one's teeth, reach prevention or the purpose for the treatment of periodontosis, Chinese herbal ultra-fine powder can be selected following multiple
Square one-tenth.
The present embodiment the first Chinese herbal ultra-fine powder disclosed is composed of the following components: rhubarb rhubarb 15 parts, prepared RADIX ET RHIZOMA RHEI
10 parts, gypsum 15 parts, the plaster of paris 10 parts, the rhizome of davallia 10 parts, the filamentary silver bark of eucommia 10 parts, blue or green salt 15 parts, salt
15 parts, each 15 parts of alumen, Radix Angelicae Sinensis and the root of Dahurain angelica, the root of Chinese wild ginger 5 parts, flos caryophylli 10 parts, the weight of above-mentioned every part is the most equal.
In this compound, adding the root of Dahurain angelica of pungent temperature, the root of Chinese wild ginger and flos caryophylli reach pain stop and anti-inflammation, swelling and pain relieving, promoting blood circulation effect.
The first Chinese herbal ultra-fine powder that the present embodiment provides, for teeth caring, can prevent or treat periodontosis, tooth pine effectively
Move and with symptoms such as purulence blood.
Disclosed in the present embodiment, the second Chinese herbal ultra-fine powder is composed of the following components: cape jasmine 10 parts, the capsule of weeping forsythia 10 parts, peppermint
10 parts, the root of large-flowered skullcap 10 parts, 6 parts of the dried rhizome of rehmannia, 6 parts of Radix Glycyrrhizae, the weight of above-mentioned every part is the most equal.Through proving, above-mentioned the
Two kinds of Chinese herbal ultra-fine powders can alleviate gum slightly swell and ache, red and swollen patient, play and preferably prevent or treat periodontosis
Effect.
The present embodiment the third Chinese herbal ultra-fine powder disclosed is composed of the following components: Eclipta prostrata 30 parts, blue or green salt 30 parts, little
30 parts of fennel, the root of Dahurain angelica 30 parts, rattletop 15 parts, the root of Chinese wild ginger 15 parts, 60 parts of gypsum, 9 parts of Chinese prickly ash, the weight of above-mentioned every part
Measure the most equal.The third Chinese herbal ultra-fine powder above-mentioned can be used in treating tooth and suppurates blood, tooth dry corrosion, and gum meat will be de-, toothache
The auxiliary treatment of traction headache, plays the effect preferably preventing or treating periodontosis.
In the embodiment of the present invention, composition is made up of Chinese medicine recombination chitosan/sodium alginate electrolyte sponge, so-called in
Medicine recombination chitosan/sodium alginate electrolyte sponge by shitosan/sodium alginate electrolyte sponge and Chinese herbal ultra-fine powder compound and
Become.Research (such as Wuhan University of Technology's journal 2006,28,25 about shitosan/sodium alginate polyelectrolyte sponge material
28. Fan Li Hong, Zhao, Huang Jin, Xu Yongmei, shitosan/sodium alginate polyelectrolyte sponge and antibacterial functions) show,
Shitosan and sodium alginate soln are mixed, utilizes cryodesiccated method successfully to prepare polyelectrolyte sponge.Utilize
Infrared spectrum confirms the polyelectrolyte complex act in composite sponge, utilizes scanning electron microscope observation to arrive introducing alginic acid simultaneously
After sodium, the aperture of sponge increases.Water absorbing properties test result shows, polyelectrolyte sponge has higher water absorption rate.Introduce
Different antiseptics and show special anti-microbial property, above-mentioned shitosan/sodium alginate electrolyte sponge has stronger suction
Aqueous energy, Chinese herbal ultra-fine powder is by the aperture being particularly well adsorbed in sponge so that the curative properties that Chinese herbal ultra-fine powder is had
Show.
There is not western medicine composition in the composition being used for preventing or treating periodontosis of embodiment of the present invention offer, so side effect
Less, and do not use antiseptic, also will not the generation of inducible resistance bacterial strain and the problem that causes flora imbalance.
The composition for preventing or treat periodontosis provided based on above-described embodiment, the embodiment of the present invention additionally provides one
Planting type teeth occlusion device, described type teeth occlusion device is made up of composition disclosed in above-described embodiment.
For the ease of the use of patient, what the present embodiment provided is used for preventing or treating the type teeth occlusion device of periodontosis is facing
Or be the arc strip extended along teeth arrangement direction.
The present embodiment provide for prevent or treat the type teeth occlusion device of periodontosis be arc strip time, user is not using
Time can save it in equipped with protection liquid box in, when needing with take with.In use, user is by arc strip
Being placed on to arrange up and down and be engaged between tooth, be engaged the regular hour (such as 10 minutes) every time, general patient makees tooth and protects
Within during strong purposes one day, using 3-5 time, seriously ill patient can increase number of times in right amount.
The present embodiment provide for prevent or treat the type teeth occlusion device of periodontosis be facing time, user can be doctor
With the help of be fixed in around tooth, long periods of wear, naturally it is also possible to periodically taking off and clean, user typically wears
Wear 1-2.Certainly, the concrete wear time of user can carry out Reasonable adjustment according to the periodontosis state of an illness.
The type teeth occlusion device preventing or treating periodontosis that is used for of embodiment of the present invention offer has only to during using
Patient is engaged or is fixed on patient teeth above, controls preparation compared to plug-in type oral cavity in background technology and uses insertion
For the mode in periodontal or hat week, operating relatively simple, and patient can use whenever and wherever possible, simplicity is stronger.
Meanwhile, the type teeth occlusion device that the present embodiment provides can tailor according to conditions of patients, and uses simple, easily
In carrying, can take at any time, and material environment friendly, safety, with natural polymer chitosan/sodium alginate polyelectrolyte sea
Silk floss is carrier, and compound Chinese medicine Ultramicro-powder is made, and prevention or result for the treatment of are preferable.
The type teeth occlusion device for preventing or treat periodontosis provided based on the present embodiment, the embodiment of the present invention additionally provides
A kind of preparation method, for preparing the above-mentioned type teeth occlusion device for preventing or treat periodontosis.Refer to accompanying drawing 1, on
The preparation method stated comprises the following steps:
S101, shitosan is dissolved in aqueous acetic acid, obtains chitosan solution.
S102, chitosan solution is mixed with sodium alginate aqueous solution, obtain mixed solution.
S103, Chinese herbal ultra-fine powder is dissolved in mixed solution, is sufficiently stirred for reaching homogenate state, obtains homogenate solution.
It should be noted that in this step S103, homogenate state refers to Chinese herbal ultra-fine powder and is in the state mixed.
In homogenate solution, solute includes the Chinese herbal ultra-fine powder of 7.7wt%～11.8wt%, the shitosan of 29.4wt%～30.8wt% and
The sodium alginate of 58.8wt%～61.5wt%.
S104, homogenate solution is poured into the mould of type teeth occlusion device in implement freeze-drying for the first time, obtain type teeth occlusion device.
Step S104 i.e. obtains Chinese medicine recombination chitosan/sodium alginate electrolyte sponge, only to form type teeth occlusion device
State exist.
It is more highly preferred to, in above-mentioned preparation method, the most also includes:
S105, by described type teeth occlusion device successively at CaCl2Wash with distilled water after NaOH solution is soaked.
S106, again to through washing after type teeth occlusion device implement second time freeze-drying.
Concrete, above-mentioned first time freeze-drying and the cryodesiccated condition of second time can be 12 DEG C～25 DEG C, aseptic.
Invention described above embodiment, is not intended that limiting the scope of the present invention.Any the present invention's
Amendment, equivalent and the improvement etc. made within spirit and principle, should be included within the scope of the present invention.
Claims (6)
1. for preventing or treat the composition of periodontosis, it is characterised in that described composition is by Chinese medicine recombination chitosan/marine alga
Sodium electrolyte sponge is made in acid, and described composition includes:
The Chinese herbal ultra-fine powder of 7.7wt%～11.8wt%；
The shitosan of 29.4wt%～30.8wt%；
The sodium alginate of 58.8wt%～61.5wt%；
Described Chinese herbal ultra-fine powder is composed of the following components:
Rhubarb 15 parts, prepared RADIX ET RHIZOMA RHEI 10 parts, gypsum 15 parts, the plaster of paris 10 parts, the rhizome of davallia 10 parts, the filamentary silver bark of eucommia 10
Part, blue or green salt 15 parts, salt 15 parts, each 15 parts of alumen, Radix Angelicae Sinensis and the root of Dahurain angelica, the root of Chinese wild ginger 5 parts, flos caryophylli 10 parts, above-mentioned often
The quality of part is the most equal.
2. for preventing or treat the type teeth occlusion device of periodontosis, it is characterised in that described type teeth occlusion device is by the claims
Composition described in 1 is made.
Type teeth occlusion device the most according to claim 2, it is characterised in that described type teeth occlusion device is along teeth arrangement side
To the arc strip extended or facing.
4. for preventing or treat the type teeth occlusion device preparation method of periodontosis, it is characterised in that comprise the following steps:
1) shitosan is dissolved in aqueous acetic acid, obtains chitosan solution；
2) chitosan solution is mixed with sodium alginate aqueous solution, obtain mixed solution；
3) Chinese herbal ultra-fine powder is dissolved in described mixed solution, is sufficiently stirred for obtaining homogenate solution, the solute of described homogenate solution
Including the Chinese herbal ultra-fine powder of 7.7wt%～11.8wt%, the shitosan of 29.4wt%～30.8wt% and 58.8wt%～
The sodium alginate of 61.5wt%；
4) freeze-drying, for the first time freeze-drying for the first time is implemented in described homogenate solution is poured into the mould of described type teeth occlusion device
Mould is gone to obtain described type teeth occlusion device after completing；
Described Chinese herbal ultra-fine powder is composed of the following components:
Rhubarb 15 parts, prepared RADIX ET RHIZOMA RHEI 10 parts, gypsum 15 parts, the plaster of paris 10 parts, the rhizome of davallia 10 parts, the filamentary silver bark of eucommia 10
Part, blue or green salt 15 parts, salt 15 parts, each 15 parts of alumen, Radix Angelicae Sinensis and the root of Dahurain angelica, the root of Chinese wild ginger 5 parts, flos caryophylli 10 parts, above-mentioned often
The quality of part is the most equal.
Preparation method the most according to claim 4, it is characterised in that step 4) also include afterwards:
By described type teeth occlusion device successively at CaCl2Wash with distilled water after the aqueous solution and the NaOH aqueous solution soak；
Again the type teeth occlusion device after washing is implemented second time freeze-drying.
Preparation method the most according to claim 4, it is characterised in that described first time freeze-drying and second time are freezing dry
Dry condition is: 12 DEG C～25 DEG C, aseptic.
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| CN201410292550.5A CN104083455B (en) | 2014-06-25 | 2014-06-25 | For preventing or treating the composition of periodontosis, type teeth occlusion device and preparation method |
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| CN201410292550.5A CN104083455B (en) | 2014-06-25 | 2014-06-25 | For preventing or treating the composition of periodontosis, type teeth occlusion device and preparation method |
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| CN104083455B true CN104083455B (en) | 2016-09-07 |
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| CN106267157B (en) * | 2015-06-03 | 2020-03-13 | 远东生物科技股份有限公司 | Composition for preventing or/and treating periodontal diseases and application thereof |
| CN111956595A (en) * | 2020-08-10 | 2020-11-20 | 自然资源部第三海洋研究所 | A dental mouthpiece for preventing or treating dental caries and periodontal disease |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1131042A (en) * | 1994-11-01 | 1996-09-18 | 东国制药株式会社 | Biodegradable sustained release preparation for treating periodontitis |
| CN103483625A (en) * | 2013-09-09 | 2014-01-01 | 戴建英 | Absorbable and degradable multipurpose biocompatible material |
-
2014
- 2014-06-25 CN CN201410292550.5A patent/CN104083455B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1131042A (en) * | 1994-11-01 | 1996-09-18 | 东国制药株式会社 | Biodegradable sustained release preparation for treating periodontitis |
| CN103483625A (en) * | 2013-09-09 | 2014-01-01 | 戴建英 | Absorbable and degradable multipurpose biocompatible material |
Non-Patent Citations (1)
| Title |
|---|
| 壳聚糖/海藻酸钠聚电解质海绵及抗菌功能;李红等;《武汉理工大学学报》;20061130;第28卷(第11期);第25-28页，尤其是第26页第2段 * |
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