CN104083150A - Method for diagnosing early cancer with color CCD camera shooting technology - Google Patents
Method for diagnosing early cancer with color CCD camera shooting technology Download PDFInfo
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- CN104083150A CN104083150A CN201410358006.6A CN201410358006A CN104083150A CN 104083150 A CN104083150 A CN 104083150A CN 201410358006 A CN201410358006 A CN 201410358006A CN 104083150 A CN104083150 A CN 104083150A
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Abstract
The invention discloses a method for diagnosing early cancer with a color CCD camera shooting technology. After light emitted by a light emitting device such as a main light source spherical mercury lamp or an LED laser is reflected by a reflective bowl plated with an ultraviolet light reflecting film and filtered with a color filter, the light becomes 395nm+/- 65nm light, and then the light turns into excitation light after being focused; after the excitation light passes through a quartz light guide fiber, the excitation light is shone to tested tissue, and the tested tissue of the human body generates fluorescence; an ultra-small CCD is directly made on an optical fiber probe, or a fluorescence image is output to the CCD through an imaging optical fiber and processed, and then the fluorescence image of the inspected tissue is displayed on a display. The method can overcome the defects in the prior art, the coincidence rate of diagnosis is higher, the method is easier for a user to accept, meanwhile the diagnosis result can be saved, and great help is provided for early diagnosis and early treatment of cancer. Through the method, X-ray radiographs, CT radiographs and the like in a hospital can be read by multiple persons currently, and clinical diagnosis is more objective.
Description
Technical field
The invention belongs to medical diagnostic method technical field, relate to specifically a kind of method of utilizing colored CCD camera technique diagnosis early cancer.
Background technology
Cancer is one of principal disease threatening human life always for a long time, and its key that is difficult to conquer is to lack effectively early stage level diagnosis technology, so how to improve early diagnosis of cancer level, is that the personage of countries in the world scientific circles makes great efforts the target of exploring always.Malignant tumor has become first or deputy reason of mankind's death, and the annual whole world approximately has 7,000,000 people to die from cancer, and China's tumor mortality number is also more than 1,000,000, and according to statistics, in from now on 20 to 30 years, the sickness rate of cancer is still in rising trend.Cervical cancer is the common malignant tumor of China women, and its sickness rate is 16.1/10 ten thousand, occupies the first place of China's gynecologic malignant tumor.The conventional method of tradition cervical carcinoma screening has smear, iodine experiment, colposcopy etc., but because resting on general form, its diagnosis principle learns, the Forbidden City neck cancer is easy to cause missed diagnosis, and the more difficult grasp of these methods of the prior art or have wound, limit its range of application, so will improve early discovery, the early diagnosis of cervical cancer, early treatment's level, reduced the mortality rate of tumor, improve the quality of life of existent, must adopt a kind of new technological means.
Low light level image is in the application of ultraviolet spectral analysis, image is the fluorescence according to the excitation tissue with 330nm ± 30nm, because the wavelength of fluorescence of human normal tissue and cancerous tissue is different, its color is also different, with the low light level CCD of 0.16 lux low-light (level), fluorescence picked-up is shown and record on display, through queried for items, reach the international leading level.It is mainly applicable to the diagnosis of short cavity road mucosal pattern early-stage cancer, as the early diagnosis of cervical cancer, oral cancer, rectal cancer, but due in product of the prior art to fluoroscopic image no record, can only make diagnosis with operator one people's impression and the assistant analysis of computer, cannot continue to analyze to case, and every instrument dispatches from the factory and all need medical practitioner to give training, the result of diagnosis cannot be held a consultation or group discussion.
Summary of the invention
The deficiency that the present invention exists in order to overcome prior art, provide a kind of doctors experience of breaking away from, not damaged, the method for utilizing colored CCD camera technique diagnosis early cancer that can locate fast, it goes for the early diagnosis of mucosal pattern cancer, as cervical cancer, oral cancer, rectal cancer etc.
The present invention is achieved by the following technical solutions: a kind of method of utilizing colored CCD camera technique diagnosis early cancer, it mainly comprises that main light source focusing, colour filter, secondary focusing, irradiation tested tissue, imaging, image are processed and the step of display demonstration, and concrete detection method is:
First main light source focuses on light through the reflector that is coated with light reflection ultraviolet film, and the light after focusing on becomes the light of 395nm ± 65nm after filtration after color chips colour filter; Then the light of 395nm ± 65nm becomes exciting light again after secondary focusing, and exciting light is irradiated in human body tested tissue after transmitting the silicon fiber that ultraviolet light efficiency is higher, and human body tested tissue produces fluorescence; Last fluorescence, through CCD photographic head treatment step, is processed by image, demonstrates the fluoroscopic image of the tested tissue of human body on display.
Main light source is ball type mercury lamp or LED laser instrument, and CCD photographic head is the CCD low light level photographic head of colored low-light (level) 0.16 lux.
Described CCD photographic head treatment step, for microminiature CCD photographic head is directly contained on fibre-optical probe, carries out image processing by fluorescence, and the fluorescence of tested tissue just can imaging on CCD by imaging fibre.
The present invention can also have another kind of embodiment, and described CCD photographic head treatment step, for the fluoroscopic image of human body tested tissue is outputed on CCD photographic head with imaging fibre, carries out image processing by fluorescence.
Basic principle of the present invention is: various materials comprise that biological chemical environment, molecular structure and the residing surrounding enviroment of tumor are different, and they have peculiar spectrum frequency separately.When certain frequencies of light is radiated on this material, under certain conditions, it is exciting light that electronics energy-absorbing transits to higher energy level, electronics great majority are in monochromatic excitation light, when if electronics directly transits to fluorescence from the radiation mode of monochromatic excitation light, by launching corresponding light quantum this process that releases energy, be just utilizing emitted light.From above-mentioned Fluorescence Mechanism, the generation of fluorescence is the different molecular structure that in molecular structure, the variation of quantum light causes, produces different wavelength of fluorescence.Although up to the present, cancerous tissue and surrounding enviroment thereof are not yet made clear, but as long as extraneous exciting light deexcitation cancerous tissue and the normal structure that has enough energy, the corresponding light quantum that oneself can absorb of their each self-absorptions, because the light quantum absorbing is different, the energy discharging is that glimmering light wavelength is also just different, therefore can differentiate normal structure and cancerous tissue accordingly.
The invention has the beneficial effects as follows: the present invention applies to colored CCD camera technique in fluorescence early cancer's diagnosis first, adopt the luminescent devices such as ball type mercury lamp or LED laser instrument as exciting light, there is the advantages such as volume is little, lightweight, operation use is simple.The present invention is applied in microminiature, highly sensitive colored CCD on fluoresence diagnostic apparatus, and exciting light probe, together with CCD design, enters the cavity of human body during inspection, and as the inspection of cervical cancer, it has advantages of that volume is little, easy and simple to handle.The present invention can also be coupled with the optical fibers of imaging human body fluorescence to CCD, make probe safety, reliable.
The present invention can overcome the defect existing in prior art after utilizing colored CCD camera technique, makes the coincidence rate of diagnosis higher, and user is more acceptant, can also preserve the result of diagnosis simultaneously, and the early diagnosis of cancer, early treatment are had to great help.The present invention can reach X-ray in Hospitals at Present, CT sheet etc. for the effect of many people read tablet, makes clinical diagnosis more objective.Diagnostic method of the present invention, when strengthening cancer prevention, improves the level of early diagnosis tumor, is no matter from reduction of expenditure or retrieves this angle of life of patient, all has positive effect.The present invention take research cervical cancer be main object, diagnostic accordance rate >=90%.
The present invention can be applied in the mechanism with Routine Medical Device, and main application units are health department and family planning system, and the initial stage is positioned at medical institutions above county level.Excitation wavelength 395nm ± 65nm of the present invention, exciting light output energy >=10mW, excitation fiber length >=1.5m, earth resistance≤0.1 Ω, has color fluorescent image display device.
Accompanying drawing explanation
Fig. 1 is the flow chart that the present invention utilizes colored CCD camera technique diagnosis early cancer's method.
The specific embodiment
Below in conjunction with accompanying drawing, the present invention is described in detail.
Embodiment 1: as shown in Figure 1, a kind of method of utilizing colored CCD camera technique diagnosis early cancer, it mainly comprises that main light source focusing, colour filter, secondary focusing, irradiation tested tissue, imaging, image are processed and the step of display demonstration, concrete detection method is: first main light source ball type mercury lamp focuses on light through being coated with the reflector of light reflection ultraviolet film, and the light after focusing on becomes the light of 395nm ± 65nm after filtration after color chips colour filter; Then the light of 395nm ± 65nm becomes exciting light again after secondary focusing, and exciting light is irradiated in human body tested tissue after transmitting the silicon fiber that ultraviolet light efficiency is higher, and human body tested tissue produces fluorescence; Last fluorescence, through colored CCD photographic head treatment step, is directly contained in microminiature CCD photographic head on fibre-optical probe, and fluorescence is carried out to image processing, by image, processes, and demonstrates the fluoroscopic image of the tested tissue of human body on display.
Embodiment 2: a kind of method of utilizing colored CCD camera technique diagnosis early cancer, and first main light source LED laser instrument focuses on light through being coated with the reflector of light reflection ultraviolet film, and the light after focusing on becomes the light of 395nm ± 65nm after filtration after color chips colour filter; Then the light of 395nm ± 65nm becomes exciting light again after secondary focusing, and exciting light is irradiated in human body tested tissue after transmitting the silicon fiber that ultraviolet light efficiency is higher, and human body tested tissue produces fluorescence; Last fluorescence, through colored CCD photographic head treatment step, outputs to the fluoroscopic image of human body tested tissue on CCD photographic head with imaging fibre, and fluorescence is carried out to image processing, by image, processes, and demonstrates the fluoroscopic image of the tested tissue of human body on display.
Finally should be noted that; above content is only in order to illustrate technical scheme of the present invention; but not limiting the scope of the invention; the simple modification that those of ordinary skill in the art carries out technical scheme of the present invention or be equal to replacement, does not all depart from essence and the scope of technical solution of the present invention.
Claims (5)
1. a method of utilizing colored CCD camera technique diagnosis early cancer, it is characterized in that: described diagnostic method mainly comprises that main light source focusing, colour filter, secondary focusing, irradiation tested tissue, imaging, image are processed and the step of display demonstration, and concrete detection method is:
First main light source focuses on light through the reflector that is coated with light reflection ultraviolet film, and the light after focusing on becomes the light of 395nm ± 65nm after filtration after color chips colour filter;
Then the light of 395nm ± 65nm becomes exciting light again after secondary focusing, and exciting light is irradiated in human body tested tissue after transmitting the silicon fiber that ultraviolet light efficiency is higher, and human body tested tissue produces fluorescence;
Last fluorescence, through CCD photographic head treatment step, is processed by image, demonstrates the fluoroscopic image of the tested tissue of human body on display.
2. a kind of method of utilizing colored CCD camera technique diagnosis early cancer according to claim 1, is characterized in that: described main light source is ball type mercury lamp or LED laser instrument.
3. a kind of method of utilizing colored CCD camera technique diagnosis early cancer according to claim 1 and 2, is characterized in that: described CCD photographic head treatment step, for microminiature CCD photographic head is directly contained on fibre-optical probe, carries out image processing by fluorescence.
4. a kind of method of utilizing colored CCD camera technique diagnosis early cancer according to claim 1 and 2, it is characterized in that: described CCD photographic head treatment step, for the fluoroscopic image of human body tested tissue is outputed on CCD photographic head with imaging fibre, carries out image processing by fluorescence.
5. a kind of method of utilizing colored CCD camera technique diagnosis early cancer according to claim 1, is characterized in that: described CCD photographic head is the CCD low light level photographic head of colored low-light (level) 0.16 lux.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104771143A (en) * | 2015-04-09 | 2015-07-15 | 江西大福康复医疗器械有限公司 | Remote intelligent optical biopsy diagnosis instrument |
| CN106175670A (en) * | 2016-06-30 | 2016-12-07 | 深圳市蓝谱里克科技有限公司 | A kind of ultraviolet image cervical carcinoma screening instrument |
| CN108814539A (en) * | 2018-05-02 | 2018-11-16 | 河南科技大学第附属医院 | A kind of diagnostic equipment of upper gastrointestinal road tumour |
| CN110057822A (en) * | 2019-04-23 | 2019-07-26 | 中国科学院深圳先进技术研究院 | A kind of optical imaging system for pathologic finding |
| CN110874857A (en) * | 2018-08-30 | 2020-03-10 | 广达电脑股份有限公司 | Image processing method and image processing device for tooth fluorescence reaction area |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104771143A (en) * | 2015-04-09 | 2015-07-15 | 江西大福康复医疗器械有限公司 | Remote intelligent optical biopsy diagnosis instrument |
| CN106175670A (en) * | 2016-06-30 | 2016-12-07 | 深圳市蓝谱里克科技有限公司 | A kind of ultraviolet image cervical carcinoma screening instrument |
| CN108814539A (en) * | 2018-05-02 | 2018-11-16 | 河南科技大学第附属医院 | A kind of diagnostic equipment of upper gastrointestinal road tumour |
| CN110874857A (en) * | 2018-08-30 | 2020-03-10 | 广达电脑股份有限公司 | Image processing method and image processing device for tooth fluorescence reaction area |
| CN110874857B (en) * | 2018-08-30 | 2023-06-06 | 广达电脑股份有限公司 | Image processing method and image processing device for tooth fluorescence reaction region |
| CN110057822A (en) * | 2019-04-23 | 2019-07-26 | 中国科学院深圳先进技术研究院 | A kind of optical imaging system for pathologic finding |
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