CN104071363A - Arginine aspirin powder injection split filling process and automatic split filing system thereof - Google Patents
Arginine aspirin powder injection split filling process and automatic split filing system thereof Download PDFInfo
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- CN104071363A CN104071363A CN201410317251.2A CN201410317251A CN104071363A CN 104071363 A CN104071363 A CN 104071363A CN 201410317251 A CN201410317251 A CN 201410317251A CN 104071363 A CN104071363 A CN 104071363A
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Abstract
The invention discloses an arginine aspirin powder injection split filling process. The arginine aspirin powder injection split filling process comprises the steps of glass bottle cleaning, glass bottle sterilization, rubber plug cleaning, rubber plug sterilization, aluminum-plastic cap sterilization, arginine aspirin powder injection split filling, glass bottle plugging, capping, light examination, labeling, packaging and the like. Arginine aspirin powder injection produced through the arginine aspirin powder injection split filling process has the advantages of being high in medicine quality and stability, good in medicinal effects and the like. The invention also discloses an automatic arginine aspirin powder injection split filling system.
Description
Technical field
The present invention relates to medical technical field, relate in particular to a kind of packing flow process and auto-loading system thereof of injection Aspirin-arginine powder-injection.
Background technology
Aspirin-arginine is aspirin and arginic double salt, also referred to as Aspirin-arginin, can suppress epoxidase, reduces the synthetic of prostaglandin, has antipyretic, analgesia, antiinflammatory action.Aspirin-arginine has not only kept original drug effect of aspirin, and changed its water-fast character, make it have good old medicine water-soluble, that make this antirheumatic pain relieving and can be made into injection, not only reduced consumption, and more quick-acting, up to now, Aspirin-arginine has become the more convenient pain relieving new drug of application.
At present, the production method of Aspirin-arginine is mainly: arginine is water-soluble, then add aspirin, stir and make the fully reaction in water under 60-80 ℃ of temperature of reaction of arginine and aspirin, after reaction, add methenyl choloride, low temperature is preserved, and separates out precipitation, filters, accretion is washed and vacuum desiccation, obtain Aspirin-arginine crude product, then aseptic subpackaged or redissolution postlyophilization, obtains injection Aspirin-arginine powder-injection.In prior art, injection Aspirin-arginine powder-injection can carry out sterilization treatment in its production process, to prevent that existing of bacterium from making injection Aspirin-arginine powder-injection rotten, thereby causes the property of medicine unstable.Injection Aspirin-arginine powder-injection will carry out packing processing after making, and in minute process of assembling, due to artificial participation and the impact of environment, can have bacterium, thereby has the defects such as the apt to deteriorate and property of medicine of medicine is unstable.
Therefore packing flow process and the auto-loading system thereof of, being badly in need of a kind of follow-on injection Aspirin-arginine powder-injection overcome above-mentioned defect.
Summary of the invention
The object of the present invention is to provide a kind of packing flow process of injection Aspirin-arginine powder-injection, use the injection Aspirin-arginine powder-injection that described packing flow process makes to there is drug quality and good stability, thus the advantage such as medicinal effects is good.
Another object of the present invention is to provide a kind of auto-loading system of injection Aspirin-arginine powder-injection, described auto-loading system can carry out packing to injection Aspirin-arginine powder-injection to automation, thereby avoid artificial participation to have bacterial contamination, have that drug quality is good, stability of drug products is good and the advantage such as medicinal effects is good.
To achieve these goals, the invention provides a kind of packing flow process of injection Aspirin-arginine powder-injection, comprise the following steps: (1) glass bottle cleans, is that 10ml glass bottle is positioned over and in cleaning machine, cleans and pass through pressurized air and dry up by specification; (2) glass bottle sterilizing, is placed on the glass bottle after cleaning in hot air sterilization device, and at 320 ℃, sterilizing is 6 minutes, then cooling standby; (3) rubber plug cleans, and rubber plug is placed on to wash in plug machine and cleans; (4) rubber plug sterilizing, by being placed in hot air sterilization device as plug after cleaning, at 121 ℃, sterilizing is 120 minutes, then cooling standby; (5) aluminium-plastic cap sterilizing, is placed on aluminium-plastic cap in baking oven, toasts sterilizing 120 minutes at 110 ℃, then cooling standby; (6) injection Aspirin-arginine powder-injection is in the clean area of 10000 grades, carries out aseptic subpackagedly with the glass bottle in step (2), then with cork stopper, the rubber plug in step (4) is pressed into the opening of described glass bottle; (7) with pricking the machine that covers, the aluminium-plastic cap in step (5) is carried out to Zha Gai to the good injection Aspirin-arginine powder-injection sample of tamponade in step (6); (8) the injection Aspirin-arginine powder-injection sample after complete to step (7) Zhong Zhagai with lamp inspection machine carries out lamp inspection; (9) the injection Aspirin-arginine powder-injection sample after lamp in step (8) examine with labelling machine carries out labeling, then packs.
Preferably, described packing flow process completes on full automatic conveyor line.
Preferably, in described step (6), packing 0.5g injection Aspirin-arginine powder-injection in each glass bottle.
Preferably, in described step (6), packing 1g injection Aspirin-arginine powder-injection in each glass bottle.
Preferably, the clean area of described 10000 grades is local arrives 100 grades.
In order to realize above-mentioned another object, the invention provides a kind of auto-loading system of injection Aspirin-arginine powder-injection, comprise the first mechanical gripper, the second mechanical gripper, the 3rd mechanical gripper, the 4th mechanical gripper, the 5th mechanical gripper, automatic subpackaging equipment, the first transport sector, the second transport sector, the 3rd transport sector, the 4th transport sector, the 5th transport sector, the 6th transport sector, the 7th transport sector and the 8th transport sector, described the first mechanical gripper is put into described cleaning machine by described glass bottle, the first transport sector is transported to the first hot air sterilization device place by the glass bottle after cleaning, the second mechanical gripper is put into described the first hot air sterilization device by the glass bottle after described cleaning and is carried out sterilization treatment, the second transport sector is transported to packing district by the glass bottle after sterilizing, the 3rd mechanical gripper is put into rubber plug to wash plug machine and clean, the 3rd transport sector is transported to the second hot air sterilization device place by the rubber plug after cleaning, the 4th mechanical gripper is put into described hot air sterilization device by the rubber plug after described cleaning and is carried out sterilization treatment, the 4th transport sector is transported to packing district by the rubber plug after sterilizing, the 5th mechanical gripper is put into baking oven by aluminium-plastic cap and is toasted sterilization treatment, the 5th transport sector is transported to packing district by the aluminium-plastic cap after baking sterilizing, in packing district, automatic subpackaging equipment divides injection Aspirin-arginine powder-injection to install in each glass bottle by the specification of 0.5g or 1g, then by cork stopper, described rubber plug is pressed into the opening of described glass bottle, the 6th transport sector is transported to the injection Aspirin-arginine powder-injection sample after described tamponade to prick and covers machine place, described bundle lid machine is pricked described aluminium-plastic cap at the rubber plug place of described injection Aspirin-arginine powder-injection sample, the 7th transport sector is transported to lamp inspection machine place by the injection Aspirin-arginine powder-injection sample after Zha Gai and carries out lamp inspection, the 8th transport sector is examined satisfactory injection Aspirin-arginine powder-injection sample by lamp and is transported to labelling machine place and carries out labeling, then pack.
In the packing flow process and auto-loading system of injection Aspirin-arginine powder-injection of the present invention, injection Aspirin-arginine powder-injection carries out aseptic subpackaged in the clean area of 10000 grades, at injection Aspirin-arginine powder-injection, pack glass bottle into and carry out before rubber plug tamponade, respectively glass bottle and rubber plug are carried out to hot air sterilization processing, and then carry out Zha Gai with the aluminium-plastic cap after baking sterilizing, because packing flow process of the present invention completes and divides the various vessel in process of assembling all to carry out sterilization treatment on auto-loading system, therefore use the injection Aspirin-arginine powder-injection that this packing flow process makes to there is drug quality and good stability, thereby the advantages such as medicinal effects is good.
The specific embodiment
Now in conjunction with specific embodiments the packing flow process of injection Aspirin-arginine powder-injection of the present invention is further described, specific as follows:
With reference to figure 1, the packing flow process of injection Aspirin-arginine powder-injection of the present invention, comprises the following steps: 1, glass bottle cleans, and by specification, is that 10ml glass bottle is positioned over and in cleaning machine, cleans and pass through pressurized air and dry up; 2, glass bottle sterilizing, is placed on the glass bottle after cleaning in the first hot air sterilization device, and at 320 ℃, sterilizing is 6 minutes, then cooling standby; 3, rubber plug cleans, and rubber plug is placed on to wash in plug machine and cleans; 4, rubber plug sterilizing, by being placed in the second hot air sterilization device as plug after cleaning, at 121 ℃, sterilizing is 120 minutes, then cooling standby; 5, aluminium-plastic cap sterilizing, is placed on aluminium-plastic cap in baking oven, toasts sterilizing 120 minutes at 110 ℃, then cooling standby; 6, injection Aspirin-arginine powder-injection is in the clean area of 10000 grades, with the glass bottle in step 2, carry out aseptic subpackaged, packing 0.5g or 1g injection Aspirin-arginine powder-injection in each glass bottle, be then pressed into the rubber plug in step 4 with cork stopper the opening of described glass bottle; 7, with bundle, cover machine the aluminium-plastic cap in step 5 is carried out to Zha Gai to the good injection Aspirin-arginine powder-injection sample of tamponade in step 6; 8, with lamp inspection machine, the injection Aspirin-arginine powder-injection sample of pricking after having covered in step 7 is carried out to lamp inspection; 9, the injection Aspirin-arginine powder-injection sample after lamp in step 8 having been examined with labelling machine carries out labeling, then packing.In the present embodiment, the clean area part of described 10000 grades reaches 100 grades.The packing flow process of injection Aspirin-arginine powder-injection of the present invention completes on full automatic conveyor line.
Above-mentioned packing flow process is to complete on the auto-loading system of injection Aspirin-arginine powder-injection, and described auto-loading system comprises the first mechanical gripper, the second mechanical gripper, the 3rd mechanical gripper, the 4th mechanical gripper, the 5th mechanical gripper, automatic subpackaging equipment, the first transport sector, the second transport sector, the 3rd transport sector, the 4th transport sector, the 5th transport sector, the 6th transport sector, the 7th transport sector and the 8th transport sector.Be specially: in step 1, by the first mechanical gripper, glass bottle is put into described cleaning machine and clean; In step 2, by the first transport sector, the glass bottle after cleaning is transported to the first hot air sterilization device place, by the second mechanical gripper, described glass bottle is put into described the first hot air sterilization device again and carry out sterilization treatment, then by the second transport sector, the glass bottle after sterilizing is transported to packing district; In step 3, by the 3rd manipulator, rubber plug is put into and washed plug machine and clean; In step 4, by the 3rd transport sector, the rubber plug after cleaning is transported to the second hot air sterilization device place, by the 4th mechanical gripper, described rubber plug is put into described the second hot air sterilization device again and carry out sterilization treatment, then by the 4th transport sector, the rubber plug after sterilizing is transported to packing district; In step 5, by the 5th mechanical gripper, aluminium-plastic cap is put into baking oven and toast sterilization treatment, then by the 5th transport sector, the aluminium-plastic cap after baking is transported to packing district; In step 6, in packing district, by automatic subpackaging equipment, injection Aspirin-arginine powder-injection is divided and installed in each glass bottle by the specification of 0.5g or 1g, then by cork stopper, described rubber plug is pressed into the opening of described glass bottle; In step 7, in packing district, by the 6th transport sector, the injection Aspirin-arginine powder-injection sample after described tamponade is transported to prick and covers machine place, by described bundle lid machine, described aluminium-plastic cap is pricked to the rubber plug place of described glass bottle; In step 8, by the 7th transport sector, the glass bottle after Zha Gai is transported to lamp inspection machine place and carries out lamp inspection; In step 9, by the 8th transport sector, lamp is examined to satisfactory injection Aspirin-arginine powder-injection sample and be transported to labelling machine place and carry out labeling.
As from the foregoing, in the packing flow process and auto-loading system of injection Aspirin-arginine powder-injection of the present invention, injection Aspirin-arginine powder-injection carries out aseptic subpackaged in the clean area of 10000 grades, at injection Aspirin-arginine powder-injection, pack glass bottle into and carry out before rubber plug tamponade, respectively glass bottle and rubber plug are carried out to hot air sterilization processing, and then carry out Zha Gai with the aluminium-plastic cap after baking sterilizing, because packing flow process of the present invention completes and divides the various vessel in process of assembling all to carry out sterilization treatment on auto-loading system, therefore use the injection Aspirin-arginine powder-injection that this packing flow process makes to there is drug quality and good stability, thereby the advantages such as medicinal effects is good.
Above disclosed is only the preferred embodiments of the present invention, certainly can not limit with this interest field of the present invention, and the equivalent variations of therefore doing according to the present patent application the scope of the claims, still belongs to the scope that the present invention is contained.
Claims (6)
1. a packing flow process for injection Aspirin-arginine powder-injection, is characterized in that, comprises the following steps:
(1) glass bottle cleans, and by specification, is that 10ml glass bottle is positioned over and in cleaning machine, cleans and pass through pressurized air and dry up;
(2) glass bottle sterilizing, is placed on the glass bottle after cleaning in the first hot air sterilization device, and at 320 ℃, sterilizing is 6 minutes, then cooling standby;
(3) rubber plug cleans, and rubber plug is placed on to wash in plug machine and cleans;
(4) rubber plug sterilizing, by being placed in the second hot air sterilization device as plug after cleaning, at 121 ℃, sterilizing is 120 minutes, then cooling standby;
(5) aluminium-plastic cap sterilizing, is placed on aluminium-plastic cap in baking oven, toasts sterilizing 120 minutes at 110 ℃, then cooling standby;
(6) injection Aspirin-arginine powder-injection is in the clean area of 10000 grades, carries out aseptic subpackagedly with the glass bottle in step (2), then with cork stopper, the rubber plug in step (4) is pressed into the opening of described glass bottle;
(7) with pricking the machine that covers, the aluminium-plastic cap in step (5) is carried out to Zha Gai to the good injection Aspirin-arginine powder-injection sample of tamponade in step (6);
(8) the injection Aspirin-arginine powder-injection sample after complete to step (7) Zhong Zhagai with lamp inspection machine carries out lamp inspection;
(9) the injection Aspirin-arginine powder-injection sample after lamp in step (8) examine with labelling machine carries out labeling, then packs.
2. the packing flow process of injection Aspirin-arginine powder-injection as claimed in claim 1, is characterized in that, described packing flow process completes on full automatic conveyor line.
3. the packing flow process of injection Aspirin-arginine powder-injection as claimed in claim 2, is characterized in that, in described step (6), and packing 0.5g injection Aspirin-arginine powder-injection in each glass bottle.
4. the packing flow process of injection Aspirin-arginine powder-injection as claimed in claim 2, is characterized in that, in described step (6), and packing 1g injection Aspirin-arginine powder-injection in each glass bottle.
5. the packing flow process of injection Aspirin-arginine powder-injection as claimed in claim 1, is characterized in that, the clean area part of described 10000 grades reaches 100 grades.
6. the auto-loading system of an injection Aspirin-arginine powder-injection, it is characterized in that, comprise the first mechanical gripper, the second mechanical gripper, the 3rd mechanical gripper, the 4th mechanical gripper, the 5th mechanical gripper, automatic subpackaging equipment, the first transport sector, the second transport sector, the 3rd transport sector, the 4th transport sector, the 5th transport sector, the 6th transport sector, the 7th transport sector and the 8th transport sector, described the first mechanical gripper is put into described cleaning machine by described glass bottle, the first transport sector is transported to the first hot air sterilization device place by the glass bottle after cleaning, the second mechanical gripper is put into described the first hot air sterilization device by the glass bottle after described cleaning and is carried out sterilization treatment, the second transport sector is transported to packing district by the glass bottle after sterilizing, the 3rd mechanical gripper is put into rubber plug to wash plug machine and clean, the 3rd transport sector is transported to the second hot air sterilization device place by the rubber plug after cleaning, the 4th mechanical gripper is put into described hot air sterilization device by the rubber plug after described cleaning and is carried out sterilization treatment, the 4th transport sector is transported to packing district by the rubber plug after sterilizing, the 5th mechanical gripper is put into baking oven by aluminium-plastic cap and is toasted sterilization treatment, the 5th transport sector is transported to packing district by the aluminium-plastic cap after baking sterilizing, in packing district, automatic subpackaging equipment divides injection Aspirin-arginine powder-injection to install in each glass bottle by the specification of 0.5g or 1g, then by cork stopper, described rubber plug is pressed into the opening of described glass bottle, the 6th transport sector is transported to the injection Aspirin-arginine powder-injection sample after described tamponade to prick and covers machine place, described bundle lid machine is pricked described aluminium-plastic cap at the rubber plug place of described injection Aspirin-arginine powder-injection sample, the 7th transport sector is transported to lamp inspection machine place by the injection Aspirin-arginine powder-injection sample after Zha Gai and carries out lamp inspection, the 8th transport sector is examined satisfactory injection Aspirin-arginine powder-injection sample by lamp and is transported to labelling machine place and carries out labeling, then pack.
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| CN201410317251.2A CN104071363A (en) | 2014-07-04 | 2014-07-04 | Arginine aspirin powder injection split filling process and automatic split filing system thereof |
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| CN201410317251.2A CN104071363A (en) | 2014-07-04 | 2014-07-04 | Arginine aspirin powder injection split filling process and automatic split filing system thereof |
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| CN108945666A (en) * | 2018-05-08 | 2018-12-07 | 广西壮传食品有限公司 | A kind of technology of the package of crisp short cakes with sesame |
| CN112938065A (en) * | 2021-02-05 | 2021-06-11 | 重庆华森制药股份有限公司 | Freeze-drying production line and production method |
| WO2021249578A3 (en) * | 2020-06-07 | 2022-01-27 | 刘力 | Medication for the prevention and treatment of asthma, chronic obstructive pulmonary disease, or allergic diseases |
| WO2021249579A3 (en) * | 2020-06-07 | 2022-01-27 | 刘力 | Medication for the prevention and treatment of cold or viral diseases |
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Application publication date: 20141001 |