CN104069315A - Sperm production formula for treating male infertility - Google Patents

Abstract

The invention provides a sperm production formula for treating male infertility. The sperm production formula has a function of nourishing kidney yin and is mainly used for treating the male infertility such as mentulagra, spermatorrhea, oligospermia and low sperm motility which are caused by deficiency of the kidney. The sperm production formula is prepared from the following raw material medicines by weight: codonopsis pilosula, rehmannia glutinosa, dioscorea opposita thunb, pulp of dogwood fruit, lycium barbarum and tortoise plastron. The sperm production formula has an excellent effect for treating the infertility due to azoospermatism, oligospermia and normal number of sperms. The composition has the excellent and rapid treatment effect for the male infertility, and has no side effect to a human body because of being prepared by utilizing natural Chinese medicine ingredients. The sperm production formula can be used for strengthening the sperms and effectively increasing the number of the sperms.

Description

One is educated sub-spermatogenesis side

Technical field

The present invention relates to a kind of medical science medicine section field, one is educated sub-spermatogenesis side.

Technical background

At present, male infertility incidence rate is 10% left and right.Wherein simple wife's side factor is about 50%, and simple bridegroom's or husband's side factor is about 30%, and men and women total approximately 20%.Clinically male sterility is divided into sexual dysfunction and normal two classes of sexual function, it is sterile that the latter can be further divided into azoospermia, oligospermatism, azoospermia, asthenospermia disease and sperm count normality according to semen analysis result.

Male infertility is except congenital deformity of testis and dysplasia, and external potential hazard is Briefs, often easily out in the cold.The contraction of scrotum is that the temperature in order to regulate testis is spent left and right lower than body temperature 2, just testis only reaches optimum state lower than the secretion that is conducive to testosterone about body temperature 2 degree.Testosterone is the important substance that promotes spermatogenesis.The Briefs of current trend close-fitting vest, general design is above all double-deck, and scrotum and penis are bundled together, and of a specified duration causes under hip for a long time in the environment of high temperature humidity, becomes the hotbed that virus and bacteria grows.Under hip, high temperature humidity is the common andropathys' such as triggering male prostatitis, varicocele, seminal vesiculitis, eczema scrotum potential danger for a long time.Prostatitis, varicocele and seminal vesiculitis are male infertility common diseases.So expert advice penetrates the cloudy Briefs with pocket for male that wind is ventilative, heat radiation has been isolated more, keeps for a long time dry and comfortable ventilative heat radiation under hip.

The etiological classification of male sterility can be according to being divided into absolute sterility (azoospermia) and relative sterility (the few or motility of sperm of sperm quantity is low etc.) fertility, primary sterility and secondary sterility can be divided into by clinical manifestation, property after property before testis, testis and testis can be divided into by sexual organ's diseased region.The reason more complicated of male sterility, is now described below with regard to main cause.

(1) dysspermatism.

1. without sperm or spermacrasia

When in seminal fluid, sperm concentration is lower than 0.2 hundred million/ml the wife's side become pregnant chance reduce, during lower than 0.2 hundred million/ml, cause sterile.Thisly sterilely be divided into permanently and temporary, the former sees congenital testicualr development obstacle or testis, the serious pathological changes person of seminal vesicle; The latter is more common in sexual life overfrequency and causes once exhaustion of spermatogenesis, is generally oligospermia instead of completely without sperm.

2. sperm quality is poor

Unvital or too much (exceeding 20%) of Necrospermia in seminal fluid, or motility of sperm is very poor or teratospermia exceedes 30%, often can cause sterile.

3. seminal fluid physicochemical character is abnormal

Normal semen is congealed into gelatin very soon after penetrating, all liquefaction again in afterwards 15～30 minutes.If seminal fluid does not solidify after penetrating, or complete normal seminal vesicle or the prostate of pointing out of liquefaction has pathological changes.Antibacterial, viral infection reproductive tract also can cause the change of seminal fluid composition so that cause sterile.In seminal fluid, pathogenic bacterium are greater than 103/ml, and non-pathogenic bacteria is greater than 104/ml and all can causes sterile.

(2) dyszoospermia.

1. the own disease of testis

As atrophy of testis after tumor of testis, tuberculosis of testis, syphilis of testis, testis nonspecific inflammation, wound or torsion of spermatic cord, testis lack as etc., all can cause spermatogenesis obstacle, occur sterile.

2. chromosomal abnormality

Sex chromosomal abnormality can make sexual organ's poorly differentiateds such as testis, causes true property hermaphrodism and Klinefelter syndrome etc.Autosomal abnormalities can cause gonad and spermatogenic cell metabolism disorder.

3. spermatogenesis dysfunction

Long-term edible Oleum Gossypii semen can affect spermatogenesis Sperm autoimmunity, also can cause spermatogenesis dysfunction.

4. local patholoic change

As sickness influences such as recessive varicocele, huge hydrocele of tunica vaginalis the external environment of testis part, or the reason such as Yin Wendu, compressing causes sterile.

(3) sperm, ovum are in conjunction with obstacle.

1.Jing blocks in road

As lacking as deformities such as lockings of congenital semen deposition pipeline, surgical ligation deferent duct, the chronic inflammatory disease of smart road and surrounding tissue thereof etc.

2. retrograde ejaculation

As bladder neck once did operation or sustain damage or perform the operation after cicatricial contracture make urethra distortion shape, after bilateral lumbar sympathectomy or after rectal cancer abdomen perineal operation, the pudendal nerve infringement that diabetes cause, cyst of spermatic cord hypertrophy, and serious urethral stricture, some drugs, can cause that as epinephrine blocker etc. the sympathetic nerve function of domination bladder changes.

3. external genitalia is abnormal

As congenital penis is scarce, as too small in penis, androgynism, epispadias or under split, posteriority penis inflammation or damage, edema of scrotum, huge hydrocele of testis etc.

4. male sexual disorder

Sexual impotence, premature ejaculation, anejaculation etc.

(4) general factor.

1. spirit and environmental factors

Living environment flip-flop causes long-term psychentonia, carries out high-altitude, high temperature, super-strength work and is engaged in lonizing radiation work.

2. trophic factor

Serious malnutrition, VitAVitE deficiency disease, trace element is as zinc, manganese deficiency, calcium, disorders of phosphorus metabolism, hydrargyrum arsenic, lead, ethanol, nicotine, cotton seed wet goods toxicant chronic poisoning, chemotherapeutics treatment etc.

3. endocrinopathy

As growth hormone deficiency dwarfism, obesity, impotence generandi syndrome, adenohypophysis hypofunction, congenital gonad aplasia disease, congenital spermatogenesis can not syndrome, high prolactin antagonist disease, pituitary tumor or intracranial infection, maternal infuries etc.

1. semen analysis

To weigh the important and easy method of male fertility, the conventional normal value standard of China's seminal fluid is: semen volume 2～6ml/ time, liquefying time <30 minute, pH value is 7.2～8.0, sperm concentration normal value is >20 × 106/ml, sperm motility >=60%, vigor a level >25%, or vigor (a+b) >50%, sperm deformity <40%.By masturbation or sperm extractor, use special glass bottle, to collect without plastic cup or condom, the specimen transfer time does not exceed 1 hour, and temperature remains on 25～35 DEG C, and the ascetic time was advisable with 3～5 days.Because sperm number and sperm quality often change, therefore answer continuous review to average for 3 times.

2. urine and examination of prostatic fluid

Leucocyte in urine increases to point out and infects or prostatitis, and after ejaculation, urine examination finds that a large amount of sperms can consider retrograde ejaculation.Prostatic fluid microscopy leukocyte >10/HP, should do prostatic fluid antibacterial culturing.

3. Reproductive Endocrine Hormones is measured

Comprise the Reproductive Endocrine Hormones such as testosterone, testosterone T, LH, FSH.In conjunction with semen analysis and health check-up, can provide the reason of differentiating infertility.As all low in T, LH, FSH, diagnosable secondary hypogonadism; Simple T declines, and LH is normal or higher, and it is constitutional gonad function exhaustion that FSH increases diagnosable; T, LH are normal, and FSH raises and is diagnosed as selectivity spermatogenic epithelium functional defect; T, LH, FSH all increase, and are diagnosed as androgen tolerance syndrome.

4. antisperm antibody inspection

Immunological infertility accounts for 2.7%～4% of male infertility, and WHO recommends mixed antiglobulin reaction test (MAR method) and immune strain test.Not only can measure infertility Mr. and Mrs serum and secretions and whether have antisperm antibody, can also can measure these antibody be combined with sperm, and distinguishes which region of which kind of antibody and sperm and be combined.In the test of antiglobulin hybrid reaction, microemulsion drips with the percentage ratio of motile sperm combination and should be less than 10%.Immunity strain test, has the microemulsion of IgA or IgG antibody to drip and sample sperm Mixed culture pan coating, antibody will with the IgA of sperm surface or IgG combination.The key of this success of the test is that sperm should be to move.If immunity strain and exceed 50% motile sperm in conjunction with just thinking the result positive, in the case of the result positive, 75% the normal demonstration of sperm contains IgA or IgG.The explanation of these antibody test results should be very careful, because some patient is contained antibody, but do not affect its fertility.

In recent years, male infertility sickness rate progressively rises, and has brought misery to many families, allows a lot of male undertake heavy mental pressure.It is reported, the whole world approximately has 15% Mr. and Mrs sterile, and wherein male sterility accounts for 40%～50%.Nearly half a century, due to the impact of the factors such as environment, psychology, society, there is obvious downward trend in the quality and quantity of mankind spermatozoon, and male reproductive health is just being subject to serious threat.Man and wife lives together more than 1 year, does not take contraceptives, because bridegroom's or husband's side factor causes the not conceived person in the wife's side, is called male sterility.Sperm quality declines and may cause the danger that is difficult to conjecture to the mankind's quality, and for this reason, people conduct extensive research the factor that affects sperm quality, finds that global environmental pollution is the main cause that causes sperm quality to decline.The environmental factors that affects sperm quality comprises.

1, metallic element: verified have hydrargyrum, lead, cadmium etc. to the virose metal of reproduction tool.These heavy metals of Long Term Contact can cause sperm number decline, sperm concentration to reduce, motility of sperm reduces, an ejaculation volume reduces and the increase of teratospermia ratio.

2, pesticide and medicine: along with agriculture development, pesticide is more and more subject to people's attention the impact of sperm quality, such as dichlorvos, Malathion, methylene blue, the indigo-blue motor capacity that can affect sperm such as red, make that the number of sperm subtracts 8 less, form changes.

3, organic substance: a lot of organic substances have toxicity to sperm, as some harmful chemicals such as benzene, formaldehyde, food additive can hinder the born and vigor of sperm, even causes atrophy of testis.

4, gas (vehicle exhaust): research discovery, the people's eupyrene sperm ratio that often sucks vehicle exhaust obviously declines.

5, radiation: sexual cell is one of cell the most responsive to radiation, excess radiation can produce harmful effect to sperm.Electromagnetic wave, radioprotective, roentgen radiation x are all human sperm's killers, can make that spermatid is abnormal, anemia of pregnant woman's miscarriage and fetal development bad.

6, temperature: high temperature can produce infringement to testis, but how high temperature and time of exposing at this temperature how long, just can exert an influence to testis actually, still have arguement at present in educational circles.In zoopery, buck is placed in to 38.5 ° of C after lower 55 minutes, will decline its fertility.In actual life, male should avoid stopping in hot environment long-time as far as possible, as washes sauna bath and bath etc. with hot water.

7. medicine: anticancer, hormones, antibiotic etc can be damaged male gonad function, cause sperm quantity and Quality Down, or by affecting the endocrine function of gonad, cause sexual dysfunction.Medicine is subject to the factor impact such as kind, dosage, the course for the treatment of, patient's age of medicine on the impact of male fecundity.Generally the dosage of use medicine is larger, the course for the treatment of is longer, patient's age is less, more serious to the infringement of reproductive function, and the recovery needed time of reproductive function is also longer.

8. psychentonia reduces sperm count

Male is along with life and the quickening of work, cause some male to have no time to take exercises, passive protective physical fitness is declined, the quality of health also just worse and worse, especially male, life stress is large, long-term life of crossing this anxiety, and health is in emergent state, especially just cause stress hormone to have influence on Hypothalamus-pituitary-testis gonad axis, can make sperm quantity obviously decline.

Summary of the invention

In order to overcome the vacancy and deficiency of prior art, the invention provides one and educate sub-spermatogenesis side, nourishing kidney yin; Kidney takes masculine sterility due to void, and male sexuality is easily lifted, seminal emission, and sperm count is few, and energy is low.

The present invention's medicine pharmacology and property of medicine used is as follows.

Radix Codonopsis:

Meridian distribution of property and flavor: sweet, flat; Return spleen, lung meridian;

Function cures mainly: invigorating the spleen and replenishing QI, spleen invigorating lung benefiting; Quench one's thirst for deficiency of the spleen and lung, the cardiopalmus of breathing hard, anorexia and loose stool, dyspnea due to deficiency cough, interior-heat.

Radix Rehmanniae Preparata:

Meridian distribution of property and flavor: sweet, tepor; Return liver, kidney channel;

Function cures mainly: nourishing YIN and supplementing blood, beneficial essence are filled out marrow; For the hepatic and renal YIN deficiency, soreness of the waist and knees, osteopyrexia and fever, night sweat seminal emission, interior-heat quench one's thirst, blood deficiency and yellow complexion, severe palpitation, menoxenia, metrostaxis, dizzy, tinnitus, early whitening of beard and hair.

Rhizoma dioscoreae:

Meridian distribution of property and flavor: sweet, flat; Return spleen, lung, kidney channel;

Function cures mainly: spleen reinforcing nourishing the stomach, the lung benefiting that promotes the production of body fluid, the kidney invigorating arresting seminal emission; For insufficiency of the spleen lack of appetite, incessant chronic diarrhea, the deficiency of the lung breath with cough, emission due to deficiency of the kidney, leukorrhagia, frequent micturition, deficiency-heat is quenched one's thirst; Rhizoma Dioscoreae (parched with bran) spleen reinforcing stomach invigorating; For insufficiency of the spleen lack of appetite, the loose stool of having loose bowels, leukorrhagia.

Fructus Corni:

Meridian distribution of property and flavor: acid, tepor; Return liver, kidney channel;

Function cures mainly: liver and kidney tonifying, convergence is solid de-, main waist is had a dizzy spell, deafness and tinnitus, soreness of the waist and knees, Xian essence spermatorrhea, frequent micturition, incessant sweating due to debility, woman uterine bleeding, interior-heat are quenched one's thirst, warming the liver the kidney invigorating, except a wind cutting, only menorrhagia, controls senile frequent micturition.

Fructus Lycii:

Meridian distribution of property and flavor: sweet, flat; Return liver, kidney channel;

Function cures mainly: nourishing the liver and kidney, replenishing vital essence to improve eyesight.For asthenia damage of essence, soreness of waist and knee joint, vertigo and tinnitus, interior-heat is quenched one's thirst, blood deficiency and yellow complexion, blurred vision is not clear.

Carapax et Plastrum Testudinis:

Meridian distribution of property and flavor: salty, sweet, be slightly cold; Return liver, kidney, heart channel;

Function cures mainly: nourishing YIN for suppressing the hyperactive YANG, kidney tonifying bone strengthening, the reinforcing the heart of nourishing blood; For deficiency of YIN hectic fever, hectic fever due to YIN-deficiency night sweat, have a dizzy spell, stirring-up of pathogenic wind in the interior resulting from deficiency, muscles and bones flaccidity are soft, it is forgetful to have a guilty conscience.

The technical scheme that the present invention solves is: one is educated sub-spermatogenesis side, is to be formed by following weight parts raw material of Chinese medicine compatibility:

Radix Codonopsis 9-30 part, Radix Rehmanniae Preparata 9-15 part, Rhizoma dioscoreae 15-30 part, Fructus Corni 6-12 part,

Fructus Lycii 6-12 part, Carapax et Plastrum Testudinis 10-24 part;

Preparation method: day 1 degree agent, decocting divides (medicine) being taken before meal 2 times.1 month for the course for the treatment of, generally need control 1-3 courses for the treatment of.

One of the present invention is educated sub-spermatogenesis side, is to be formed by following weight parts raw material of Chinese medicine compatibility:

15 parts of Radix Codonopsis, 15 parts, Radix Rehmanniae Preparata, 15 parts of Rhizoma dioscoreaes, 10 parts of Fructus Corni,

12 parts of Fructus Lyciis, 10 parts of Carapax et Plastrum Testudiniss.

The invention has the beneficial effects as follows: kidney takes masculine sterility due to void, and male sexuality is easily lifted, seminal emission, sperm count is few, and energy is low.

Tool of the present invention has the following advantages: it is fast to the splendid curative effect of male sterility effect originally to educate sub-spermatogenesis side, and natural Chinese medicine medicinal ingredient has no side effect to health.

Detailed description of the invention

Embodiment: we observe treatment 6 examples, all effective, 3 examples of wherein fully recovering, conceived 1 example.We are that masculine sterility is set due to deficiency of the kidney yin, and clinical card is shown in: waist is aching and limp, and god is tired weak, dizzy tinnitus, insomnia forgetfulness, male sexuality is easily lifted, seminal emission, and vexed night sweat, xerostomia is wish drink not, and body of the tongue is partially red, with tongue or thin coating, thready pulse and micro-number, sperm count is few, and energy is low etc.Assertive evidence is shown in few essence, the low person of motility of sperm, can give the loose cooperation of spermatogenesis.

Above-described embodiment is preferably embodiment of the present invention, but embodiments of the present invention are not restricted to the described embodiments, and the present invention not part of detailed description is known technology.

Claims (2)

1. educate sub-spermatogenesis side for one kind, it is characterized in that: be to be formed by following weight parts raw material of Chinese medicine compatibility:

Radix Codonopsis 9-30 part, Radix Rehmanniae Preparata 9-15 part, Rhizoma dioscoreae 15-30 part, Fructus Corni 6-12 part,

Fructus Lycii 6-12 part, Carapax et Plastrum Testudinis 10-24 part;

Preparation method: day 1 degree agent, decocting divides (medicine) being taken before meal 2 times; 1 month for the course for the treatment of, generally need control 1-3 courses for the treatment of.

2. one according to claim 1 is educated sub-spermatogenesis side, it is characterized in that: formed by following weight parts raw material of Chinese medicine compatibility:

15 parts of Radix Codonopsis, 15 parts, Radix Rehmanniae Preparata, 15 parts of Rhizoma dioscoreaes, 10 parts of Fructus Corni,

12 parts of Fructus Lyciis, 10 parts of Carapax et Plastrum Testudiniss.