CN104058966B - A kind of from honeysuckle the device of chlorogenic acid extracting - Google Patents
A kind of from honeysuckle the device of chlorogenic acid extracting Download PDFInfo
- Publication number
- CN104058966B CN104058966B CN201410298565.2A CN201410298565A CN104058966B CN 104058966 B CN104058966 B CN 104058966B CN 201410298565 A CN201410298565 A CN 201410298565A CN 104058966 B CN104058966 B CN 104058966B
- Authority
- CN
- China
- Prior art keywords
- chlorogenic acid
- honeysuckle
- ultrasonic extraction
- acid extracting
- enrichment facility
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/48—Separation; Purification; Stabilisation; Use of additives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Abstract
The invention provides a kind of from honeysuckle the device of chlorogenic acid extracting, comprise ultrasonic extraction device, ultrafiltration apparatus, centrifugal device, enrichment facility, tomography devices, crystallizer, purifier, recrystallization device, drying plant; Described ultrasonic extraction device, ultrafiltration apparatus, centrifugal device, enrichment facility, crystallizer, purifier, recrystallization device, drying plant connect successively; Described ultrasonic extraction device is continuous ultrasonic extraction element; Described enrichment facility is two Room inspissators, articulamentum desorption device between two Room. The present invention has realized the suitability for industrialized production of chlorogenic acid extracting from honeysuckle, has ensured the feasible of long-time chlorogenic acid extracting in enormous quantities; The total yield that can ensure chlorogenic acid is greater than 3.1%, and recovery rate is not less than 90%, in industry-leading level; Energy-conserving and environment-protective, production cost are low; Production process is safe and reliable.
Description
Technical field
The present invention relates to a kind of from honeysuckle the device of chlorogenic acid extracting.
Background technology
Chlorogenic acid is the main component of anti-inflammation in honeysuckle, is widely applied to picture silver yellow oralIn liquid, Injectio Folii Isatidis Composita etc. Domestic Honegsukle flower P.E manufacturing enterprise is numerous, at presentContaining chlorogenic acid 20-40%, 160-600 yuan/kg of price, produce market is fine. But due to priceOn the low side, manufacturing enterprise's benefit is not ideal enough. Along with improving constantly of chlorogenic acid purity, market priceLattice can rise rapidly.
For chlorogenic acid extracting from honeysuckle, although have a large amount of methods in prior art from reasonIn opinion, can obtain the recovery rate of higher chlorogenic acid, but actual in suitability for industrialized production, green formerThe recovery rate of acid is often lower, and the higher method of recovery rate is difficult to be applicable to industrialization lifeProduce.
As Chinese invention patent " a kind of extraction element (publication number of Honegsukle flower P.ECN103638086A, an open day 2014.03.19) " a kind of applicable suitability for industrialized production gold is providedHoneysuckle flower extraction element, but this extraction element is no more than for the recovery rate of Honegsukle flower P.E70%, meanwhile, although realize the extraction to honeysuckle from industrialized angle, cannot be singleSolely chlorogenic acid extracting, makes to contain in extract a large amount of impurity.
Summary of the invention
For solving the problems of the technologies described above, the invention provides one chlorogenic acid extracting from honeysuckleDevice, should be from honeysuckle device of chlorogenic acid extracting pass through
The present invention is achieved by the following technical programs.
Provided by the invention a kind of from honeysuckle the device of chlorogenic acid extracting, comprise ultrasonic extractionEquipment, ultrafiltration apparatus, centrifugal device, enrichment facility, tomography devices, crystallizer, purifier,Recrystallization device, drying plant; Described ultrasonic extraction device, ultrafiltration apparatus, centrifugal device,Enrichment facility, crystallizer, purifier, recrystallization device, drying plant connect successively; DescribedUltrasonic extraction device is continuous ultrasonic extraction element; Described enrichment facility is two Room inspissators,Articulamentum desorption device between two Room.
Described ultrasonic extraction device is continuous flow upstream ultrosonic extractor.
Described tomography devices for according to the difference of molecular weight effectively remove polysaccharide compound andTannin class material.
Before described ultrasonic extraction device, be directly connected with grinder.
After described drying plant, directly connect product collector.
Beneficial effect of the present invention is: 1. realized the industry of chlorogenic acid extracting from honeysuckleChange and produce, ensured the feasible of long-time chlorogenic acid extracting in enormous quantities; 2. can ensure chlorogenic acidTotal yield is greater than 3.1%, and recovery rate is not less than 90%, in industry-leading level; 3. energy-saving ringProtect, production cost is low; 4. production process is safe and reliable.
Brief description of the drawings
Fig. 1 is structural representation of the present invention;
In figure: 11-grinder, 12-ultrasonic extraction device, 13-ultrafiltration apparatus, the centrifugal dress of 14-Put 21-enrichment facility, 22-tomography devices, 23-crystallizer, 24-purifier, 25-recrystallizationDevice, 26-drying plant, 27-product collector.
Detailed description of the invention
Further describe technical scheme of the present invention below, but claimed scope is not limited toIn described.
The device of as shown in Figure 1 a kind of chlorogenic acid extracting from honeysuckle, comprises ultrasonic extractionEquipment 12, ultrafiltration apparatus 13, centrifugal device 14, enrichment facility 21, tomography devices 22, crystallizationDevice 23, purifier 24, recrystallization device 25, drying plant 26; Described ultrasonic extraction device 12,Ultrafiltration apparatus 13, centrifugal device 14, enrichment facility 21, crystallizer 23, purifier 24, heavy knotBrilliant device 25, drying plant 26 connect successively; Described ultrasonic extraction device 12 is continuous ultrasonicExtraction element; Described enrichment facility 21 is two Room inspissators, articulamentum desorption device 22 between two Room.
Described ultrasonic extraction device 12 is continuous flow upstream ultrosonic extractor.
Described tomography devices 22 is for effectively removing polysaccharide compound according to the difference of molecular weightWith tannin class material.
Before described ultrasonic extraction device 12, be directly connected with grinder 11.
After described drying plant 26, directly connect product collector 27.
The present invention adopts following extracting method in using: honeysuckle → pulverizing → ultrasonic extraction → mistakeFilter → centrifugal → concentrated → chromatography → concentrated → crystallization → purifying → recrystallization → oven dry → green formerAcid finished product. Wherein, concentrated → chromatography → concentrated process is that two Room are concentrated by enrichment facility 21Device, between two Room, articulamentum desorption device 22 is realized, and in the enrichment facility 21 being wholely set, hasTwo cavitys, the outlet of one of them cavity is connected to tomography devices 22 entrances, another one chamberThe outlet of the entrance articulamentum desorption device 22 of body, ensures that concentration process power consumption is few thus.
Meanwhile, adopt effective combination of continuous ultrasonic extraction, centrifugation, and binder courseAnalyse technology, thereby effectively ensure total yield relatively high in chlorogenic acid leaching process and extractionRate, and above-mentioned technology is the class that numerous extractive technique medium velocities are fast, efficiency is high, is applicable toIndustrialized mass.
On the other hand, adopt the solution of the present invention chlorogenic acid extracting from honeysuckle, can effectively protectThe realization of card low cost, high production, its pilot process is without a large amount of other raw materials that add, therebyReduce possible raw material loss, also avoided the equipment that may occur in practical operation simultaneouslyThe risk that fault causes raw material proportioning mistake to be brought.
Claims (5)
1. a device for chlorogenic acid extracting from honeysuckle, comprise ultrasonic extraction device (12),Ultrafiltration apparatus (13), centrifugal device (14), enrichment facility (21), tomography devices (22),Crystallizer (23), purifier (24), recrystallization device (25), drying plant (26), itsBe characterised in that: described ultrasonic extraction device (12), ultrafiltration apparatus (13), centrifugal device (14),Enrichment facility (21), crystallizer (23), purifier (24), recrystallization device (25), bakingDry equipment (26) connects successively; Described ultrasonic extraction device (12) is continuous ultrasonic extractionDevice; Described enrichment facility (21) is two Room inspissators, articulamentum desorption device (22) between two Room.
As claimed in claim 1 from honeysuckle the device of chlorogenic acid extracting, its feature existsIn: described ultrasonic extraction device (12) is continuous flow upstream ultrosonic extractor.
As claimed in claim 1 from honeysuckle the device of chlorogenic acid extracting, its feature existsIn: described tomography devices (22) is for effectively removing polysaccharide chemical combination according to the difference of molecular weightThing and tannin class material.
As claimed in claim 1 from honeysuckle the device of chlorogenic acid extracting, its feature existsIn: described ultrasonic extraction device (12) is directly connected with grinder (11) before.
As claimed in claim 1 from honeysuckle the device of chlorogenic acid extracting, its feature existsIn: described drying plant (26) directly connects product collector (27) afterwards.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410298565.2A CN104058966B (en) | 2014-06-26 | 2014-06-26 | A kind of from honeysuckle the device of chlorogenic acid extracting |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410298565.2A CN104058966B (en) | 2014-06-26 | 2014-06-26 | A kind of from honeysuckle the device of chlorogenic acid extracting |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104058966A CN104058966A (en) | 2014-09-24 |
| CN104058966B true CN104058966B (en) | 2016-05-25 |
Family
ID=51546940
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410298565.2A Expired - Fee Related CN104058966B (en) | 2014-06-26 | 2014-06-26 | A kind of from honeysuckle the device of chlorogenic acid extracting |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104058966B (en) |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001012178A1 (en) * | 1999-08-16 | 2001-02-22 | Microplants Co., Ltd | Method for isolating chlorogenic acid and 1,4-di-o-caffeoyl-d-(+)-quinic acid |
| CN1746149A (en) * | 2005-09-29 | 2006-03-15 | 深圳清华大学研究院 | Preparation of high-purity caffeoyl guinic acid from honeysuckle coarse extract |
| CN1810763A (en) * | 2005-01-28 | 2006-08-02 | 李全才 | Honeysuckle chlorogenic acid extracting technology |
| CN101838200A (en) * | 2009-03-20 | 2010-09-22 | 上海中医药大学 | Method for extracting and separating chlorogenic acid from honeysuckle |
| CN101851163A (en) * | 2010-06-10 | 2010-10-06 | 桂阳济草堂药材种业有限公司 | Method for extracting high-purity chlorogenic acid from honey suckle flower |
| CN102001946A (en) * | 2010-11-11 | 2011-04-06 | 湖南中健欣元生物科技有限公司 | Novel method for simultaneously extracting and separating chlorogenic acid and honeysuckle flower essential oil from honeysuckle flower |
| CN103333067A (en) * | 2013-06-13 | 2013-10-02 | 广西金昊生物科技有限公司 | Extraction method of high-purity chlorogenic acid |
| CN103373923A (en) * | 2012-04-28 | 2013-10-30 | 贵州恒和制药有限公司 | Extraction technology for efficiently and industrially producing high-purity flos lonicerae chlorogenic acid |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2665990B2 (en) * | 1990-10-04 | 1997-10-22 | 長谷川香料株式会社 | Method for producing purified chlorogenic acid |
-
2014
- 2014-06-26 CN CN201410298565.2A patent/CN104058966B/en not_active Expired - Fee Related
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001012178A1 (en) * | 1999-08-16 | 2001-02-22 | Microplants Co., Ltd | Method for isolating chlorogenic acid and 1,4-di-o-caffeoyl-d-(+)-quinic acid |
| CN1810763A (en) * | 2005-01-28 | 2006-08-02 | 李全才 | Honeysuckle chlorogenic acid extracting technology |
| CN1746149A (en) * | 2005-09-29 | 2006-03-15 | 深圳清华大学研究院 | Preparation of high-purity caffeoyl guinic acid from honeysuckle coarse extract |
| CN101838200A (en) * | 2009-03-20 | 2010-09-22 | 上海中医药大学 | Method for extracting and separating chlorogenic acid from honeysuckle |
| CN101851163A (en) * | 2010-06-10 | 2010-10-06 | 桂阳济草堂药材种业有限公司 | Method for extracting high-purity chlorogenic acid from honey suckle flower |
| CN102001946A (en) * | 2010-11-11 | 2011-04-06 | 湖南中健欣元生物科技有限公司 | Novel method for simultaneously extracting and separating chlorogenic acid and honeysuckle flower essential oil from honeysuckle flower |
| CN103373923A (en) * | 2012-04-28 | 2013-10-30 | 贵州恒和制药有限公司 | Extraction technology for efficiently and industrially producing high-purity flos lonicerae chlorogenic acid |
| CN103333067A (en) * | 2013-06-13 | 2013-10-02 | 广西金昊生物科技有限公司 | Extraction method of high-purity chlorogenic acid |
Non-Patent Citations (2)
| Title |
|---|
| 崔春雨.金银花中绿原酸的高效分离方法研究.《中国优秀硕士学位论文全文数据库电子期刊工程Ⅰ辑》.2012,6-23. * |
| 胡鲜宝等.绿原酸提取纯化及检测方法的研究进展.《农产品加工》.2009,(第11期),85-88. * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN104058966A (en) | 2014-09-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104496956B (en) | A kind of flavones ingredient extraction and separation method based on amination Graphene | |
| CN103265520B (en) | Method for preparing oligomeric proanthocyanidins and tannin pigment from grape seeds after winemaking | |
| CN102219866B (en) | Method for extracting and separating ganoderma lucidum polysaccharide from ganoderma lucidum sporocarp | |
| CN205061932U (en) | Extraction element of blueberry anthocyanidin | |
| CN101829501A (en) | Combined membrane filtering method for Chinese traditional medicine extraction, separation and concentration | |
| CN102585545A (en) | Preparation method for water gardenia flavochrome | |
| CN102633900A (en) | Method for extracting and purifying polysaccharide from Cordyceps militaris | |
| CN104587063A (en) | Method for extracting total flavonoids from Adinandra nitida Merr.ex H.L.Li | |
| CN203916141U (en) | A kind of gynostemma pentaphylla flavones and polysaccharide extract the device of purifying continuously | |
| CN104058966B (en) | A kind of from honeysuckle the device of chlorogenic acid extracting | |
| CN203458833U (en) | Continuous extracting, concentrating and drying production line | |
| CN104926719A (en) | Method for extracting gynesine from fructus cannabis | |
| CN203677997U (en) | Device for extracting tea saponin by adopting water extraction method | |
| CN102204950B (en) | Method for extracting flavonoid from liquorice waste residue | |
| CN204298288U (en) | A kind of extraction element of Flos Lonicerae chlorogenic acid | |
| CN102321125A (en) | Process for extracting gallotannic acid from galla chinensis | |
| CN101993459A (en) | Process for extraction separation of bamboo leaf flavonoids by two aqueous phases | |
| CN104172179A (en) | Extraction method of tea polyphenol | |
| CN104045733B (en) | A kind of take T.lobayense Heim as the method for raw material extraction and isolation T.lobayense Heim polysaccharide TLH-3 | |
| CN103432205A (en) | Novel method for extracting high-purity lotus leaf flavone | |
| CN203360344U (en) | Integrated system device for gardenia extract membrane separation | |
| CN103408627A (en) | Method for extracting and purifying euonymin A | |
| CN205109405U (en) | Plant extract separation and purification device | |
| CN106565813B (en) | The processing method that a kind of Tea Saponin continuously purifies | |
| CN202011849U (en) | Equipment for extracting and concentrating polysaccharide from medicinal materials |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20160525 Termination date: 20180626 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |