CN104058966A - Device for extracting chlorogenic acid from honeysuckle flower - Google Patents
Device for extracting chlorogenic acid from honeysuckle flower Download PDFInfo
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- CN104058966A CN104058966A CN201410298565.2A CN201410298565A CN104058966A CN 104058966 A CN104058966 A CN 104058966A CN 201410298565 A CN201410298565 A CN 201410298565A CN 104058966 A CN104058966 A CN 104058966A
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- CN
- China
- Prior art keywords
- chlorogenic acid
- ultrasonic extraction
- japanese honeysuckle
- acid extracting
- drying plant
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/48—Separation; Purification; Stabilisation; Use of additives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Abstract
The invention provides a device for extracting chlorogenic acid from honeysuckle flower, which comprises an ultrasonic extractor, an ultrafilter, a centrifuge, a concentrator, a chromatographic plant, a crystallizer, a purifier, a recrystallizer and a drying plant, wherein the ultrasonic extractor, ultrafilter, centrifuge, concentrator, crystallizer, purifier, recrystallizer and drying plant are sequentially connected; the ultrasonic extractor is a continuous ultrasonic extractor; the concentrator is a double-chamber concentrator; and the chromatographic plant is connected between the two chambers. The device implements industrial production of extracting chlorogenic acid from honeysuckle flower, and ensures the feasibility for mass long-time extraction of chlorogenic acid; the device can ensure the total yield of the chlorogenic acid to be greater than 3.1% and the extraction rate to be not lower than 90%, and is in the industry leading level; and the device has the advantages of energy saving, environmental protection, low production cost and safe and reliable production process.
Description
Technical field
The present invention relates to a kind of from Japanese Honeysuckle the device of chlorogenic acid extracting.
Background technology
Chlorogenic acid is the main component of antisepsis and anti-inflammation in Japanese Honeysuckle, is widely applied in picture YINHUANG KOUFUYE, Injectio Folii Isatidis Composita etc.Domestic Flos Lonicerae extract manufacturing enterprise is numerous, at present containing chlorogenic acid 20-40%, and 160-600 yuan/kg of price, produce market is fine.But due on the low side, manufacturing enterprise's benefit is not ideal enough.Along with improving constantly of chlorogenic acid purity, market value can rise rapidly.
For chlorogenic acid extracting from Japanese Honeysuckle, although there is a large amount of methods can obtain the extraction yield of higher chlorogenic acid theoretically in prior art, but actual in suitability for industrialized production, the extraction yield of chlorogenic acid is often lower, and the higher method of extraction yield is difficult to be applicable to suitability for industrialized production.
As Chinese invention patent " a kind of extraction element of Flos Lonicerae extract (publication number CN103638086A; open day 2014.03.19) " provides a kind of applicable suitability for industrialized production Japanese Honeysuckle extraction element, but this extraction element is no more than 70% for the extraction yield of Flos Lonicerae extract, simultaneously, although realized the extraction to Japanese Honeysuckle from industrialized angle, but chlorogenic acid extracting separately, makes to contain in extract a large amount of impurity.
Summary of the invention
For solving the problems of the technologies described above, the invention provides a kind of from Japanese Honeysuckle the device of chlorogenic acid extracting, should from Japanese Honeysuckle, pass through by device of chlorogenic acid extracting
The present invention is achieved by the following technical programs.
Provided by the invention a kind of from Japanese Honeysuckle the device of chlorogenic acid extracting, comprise ultrasonic extraction device, ultra-filtration equipment, centrifugal device, concentrating unit, tomography devices, crystallizer, purifier, recrystallization device, drying plant; Described ultrasonic extraction device, ultra-filtration equipment, centrifugal device, concentrating unit, crystallizer, purifier, recrystallization device, drying plant connect successively; Described ultrasonic extraction device is continuous ultrasonic extraction element; Described concentrating unit is two Room thickeners, articulamentum desorption device between two Room.
Described ultrasonic extraction device is continuous countercurrent ultrosonic extractor.
Described tomography devices is for effectively removing polysaccharide compound and tannin class material according to the difference of molecular weight.
Before described ultrasonic extraction device, be directly connected with pulverizer.
After described drying plant, directly connect product collector.
Beneficial effect of the present invention is: 1. realized the suitability for industrialized production of chlorogenic acid extracting from Japanese Honeysuckle, guaranteed the feasible of long-time chlorogenic acid extracting in enormous quantities; The total yield that 2. can guarantee chlorogenic acid is greater than 3.1%, and extraction yield is not less than 90%, in industry-leading level; 3. energy-conserving and environment-protective, production cost are low; 4. production process is safe and reliable.
Accompanying drawing explanation
Fig. 1 is structural representation of the present invention;
In figure: 11-pulverizer, 12-ultrasonic extraction device, 13-ultra-filtration equipment, 14-centrifugal device, 21-concentrating unit, 22-tomography devices, 23-crystallizer, 24-purifier, 25-recrystallization device, 26-drying plant, 27-product collector.
Embodiment
Further describe technical scheme of the present invention below, but described in claimed scope is not limited to.
The device of as shown in Figure 1 a kind of chlorogenic acid extracting from Japanese Honeysuckle, comprises ultrasonic extraction device 12, ultra-filtration equipment 13, centrifugal device 14, concentrating unit 21, tomography devices 22, crystallizer 23, purifier 24, recrystallization device 25, drying plant 26; Described ultrasonic extraction device 12, ultra-filtration equipment 13, centrifugal device 14, concentrating unit 21, crystallizer 23, purifier 24, recrystallization device 25, drying plant 26 connect successively; Described ultrasonic extraction device 12 is continuous ultrasonic extraction element; Described concentrating unit 21 is two Room thickeners, articulamentum desorption device 22 between two Room.
Described ultrasonic extraction device 12 is continuous countercurrent ultrosonic extractor.
Described tomography devices 22 is for effectively removing polysaccharide compound and tannin class material according to the difference of molecular weight.
Before described ultrasonic extraction device 12, be directly connected with pulverizer 11.
After described drying plant 26, directly connect product collector 27.
The present invention adopts following extracting method in using: Japanese Honeysuckle → pulverizing → supersound extraction → filtration → centrifugal → concentrated → chromatography → concentrated → crystallization → purifying → recrystallization → oven dry → chlorogenic acid finished product.Wherein, concentrated → chromatography → concentrated process is two Room thickeners by concentrating unit 21, between two Room, articulamentum desorption device 22 is realized, in the concentrating unit 21 being wholely set, there are two cavitys, the outlet of one of them cavity is connected to tomography devices 22 entrances, the outlet of the entrance articulamentum desorption device 22 of another one cavity, guarantees that concentration process power consumption is few thus.
Simultaneously, adopt effective combination of continuous ultrasonic extraction, centrifugation, and in conjunction with chromatographic technique, thereby effectively guarantee total yield relatively high in chlorogenic acid leaching process and extraction yield, and above-mentioned technology is the class that numerous extractive technique medium velocities are fast, efficiency is high, be applicable to industrialized mass.
On the other hand, adopt the solution of the present invention chlorogenic acid extracting from Japanese Honeysuckle, can effectively guarantee the realization of low cost, high production, its pilot process is without a large amount of other raw materials that add, thereby reduced possible starting material loss, the risk that the equipment failure of simultaneously also having avoided may occurring in actually operating causes proportioning raw materials mistake to be brought.
Claims (5)
1. the device of a chlorogenic acid extracting from Japanese Honeysuckle, comprise ultrasonic extraction device (12), ultra-filtration equipment (13), centrifugal device (14), concentrating unit (21), tomography devices (22), crystallizer (23), purifier (24), recrystallization device (25), drying plant (26), it is characterized in that: described ultrasonic extraction device (12), ultra-filtration equipment (13), centrifugal device (14), concentrating unit (21), crystallizer (23), purifier (24), recrystallization device (25), drying plant (26) connect successively; Described ultrasonic extraction device (12) is continuous ultrasonic extraction element; Described concentrating unit (21) is two Room thickeners, articulamentum desorption device (22) between two Room.
As claimed in claim 1 from Japanese Honeysuckle the device of chlorogenic acid extracting, it is characterized in that: described ultrasonic extraction device (12) is continuous countercurrent ultrosonic extractor.
As claimed in claim 1 from Japanese Honeysuckle the device of chlorogenic acid extracting, it is characterized in that: described tomography devices (22) is for effectively removing polysaccharide compound and tannin class material according to the difference of molecular weight.
As claimed in claim 1 from Japanese Honeysuckle the device of chlorogenic acid extracting, it is characterized in that: described ultrasonic extraction device (12) is directly connected with pulverizer (11) before.
As claimed in claim 1 from Japanese Honeysuckle the device of chlorogenic acid extracting, it is characterized in that: described drying plant (26) directly connects product collector (27) afterwards.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410298565.2A CN104058966B (en) | 2014-06-26 | 2014-06-26 | A kind of from honeysuckle the device of chlorogenic acid extracting |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410298565.2A CN104058966B (en) | 2014-06-26 | 2014-06-26 | A kind of from honeysuckle the device of chlorogenic acid extracting |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104058966A true CN104058966A (en) | 2014-09-24 |
| CN104058966B CN104058966B (en) | 2016-05-25 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410298565.2A Expired - Fee Related CN104058966B (en) | 2014-06-26 | 2014-06-26 | A kind of from honeysuckle the device of chlorogenic acid extracting |
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Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH04145049A (en) * | 1990-10-04 | 1992-05-19 | T Hasegawa Co Ltd | Production of purified chlorogenic acid |
| WO2001012178A1 (en) * | 1999-08-16 | 2001-02-22 | Microplants Co., Ltd | Method for isolating chlorogenic acid and 1,4-di-o-caffeoyl-d-(+)-quinic acid |
| CN1746149A (en) * | 2005-09-29 | 2006-03-15 | 深圳清华大学研究院 | Preparation of high-purity caffeoyl guinic acid from honeysuckle coarse extract |
| CN1810763A (en) * | 2005-01-28 | 2006-08-02 | 李全才 | Honeysuckle chlorogenic acid extracting technology |
| CN101838200A (en) * | 2009-03-20 | 2010-09-22 | 上海中医药大学 | Method for extracting and separating chlorogenic acid from honeysuckle |
| CN101851163A (en) * | 2010-06-10 | 2010-10-06 | 桂阳济草堂药材种业有限公司 | Method for extracting high-purity chlorogenic acid from honey suckle flower |
| CN102001946A (en) * | 2010-11-11 | 2011-04-06 | 湖南中健欣元生物科技有限公司 | Novel method for simultaneously extracting and separating chlorogenic acid and honeysuckle flower essential oil from honeysuckle flower |
| CN103333067A (en) * | 2013-06-13 | 2013-10-02 | 广西金昊生物科技有限公司 | Extraction method of high-purity chlorogenic acid |
| CN103373923A (en) * | 2012-04-28 | 2013-10-30 | 贵州恒和制药有限公司 | Extraction technology for efficiently and industrially producing high-purity flos lonicerae chlorogenic acid |
-
2014
- 2014-06-26 CN CN201410298565.2A patent/CN104058966B/en not_active Expired - Fee Related
Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH04145049A (en) * | 1990-10-04 | 1992-05-19 | T Hasegawa Co Ltd | Production of purified chlorogenic acid |
| WO2001012178A1 (en) * | 1999-08-16 | 2001-02-22 | Microplants Co., Ltd | Method for isolating chlorogenic acid and 1,4-di-o-caffeoyl-d-(+)-quinic acid |
| CN1810763A (en) * | 2005-01-28 | 2006-08-02 | 李全才 | Honeysuckle chlorogenic acid extracting technology |
| CN1746149A (en) * | 2005-09-29 | 2006-03-15 | 深圳清华大学研究院 | Preparation of high-purity caffeoyl guinic acid from honeysuckle coarse extract |
| CN101838200A (en) * | 2009-03-20 | 2010-09-22 | 上海中医药大学 | Method for extracting and separating chlorogenic acid from honeysuckle |
| CN101851163A (en) * | 2010-06-10 | 2010-10-06 | 桂阳济草堂药材种业有限公司 | Method for extracting high-purity chlorogenic acid from honey suckle flower |
| CN102001946A (en) * | 2010-11-11 | 2011-04-06 | 湖南中健欣元生物科技有限公司 | Novel method for simultaneously extracting and separating chlorogenic acid and honeysuckle flower essential oil from honeysuckle flower |
| CN103373923A (en) * | 2012-04-28 | 2013-10-30 | 贵州恒和制药有限公司 | Extraction technology for efficiently and industrially producing high-purity flos lonicerae chlorogenic acid |
| CN103333067A (en) * | 2013-06-13 | 2013-10-02 | 广西金昊生物科技有限公司 | Extraction method of high-purity chlorogenic acid |
Non-Patent Citations (2)
| Title |
|---|
| 崔春雨: "金银花中绿原酸的高效分离方法研究", 《中国优秀硕士学位论文全文数据库电子期刊工程Ⅰ辑》 * |
| 胡鲜宝等: "绿原酸提取纯化及检测方法的研究进展", 《农产品加工》 * |
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| CN104058966B (en) | 2016-05-25 |
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