CN104056272A - Prescription, delivering device and preparation method for compound ointment used for treating colpitis - Google Patents
Prescription, delivering device and preparation method for compound ointment used for treating colpitis Download PDFInfo
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- CN104056272A CN104056272A CN201310089149.7A CN201310089149A CN104056272A CN 104056272 A CN104056272 A CN 104056272A CN 201310089149 A CN201310089149 A CN 201310089149A CN 104056272 A CN104056272 A CN 104056272A
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Abstract
The invention discloses a prescription, a portable delivering device and a preparation method for a compound ointment used for treating colpitis. The invention is characterized in that the compound ointment is prepared from the following components by using specially-produced internal and external packing according to specific flow process: on the basis of weight, 5% of a main drug A (which is one selected from 5-nitroimidazole antibiotics), 4% of a main drug B (which is one selected from azole antifungals), 0.2% of a main drug C (which is one selected from cationic bactericides) and matrix adjuvant (consisting of 5% of sodium carboxymethyl starch, 0.3% of carboxymethylcellulose sodium, 20% of glycerin and 65.5% of purified water). The ointment is prepared from the above-mentioned materials by using a specific process and is then sealed in the portable delivering device. The invention has the following beneficial effects: the ointment has small granularity and improved drug effects, is uniform, fine and properly viscous, can be easily smeared on the mucous membrane of a focus of the vagina, is convenient to carry when one goes out, eliminates discomforts like pain during vaginal administration, enhances medication comfort and treatment compliance and shortens a treatment period.
Description
The invention discloses one and treat colpitic compound ointment preparation prescription, portable medicine feeding machine and preparation method thereof.
Vaginitis is the inflammation of connective tissue under vaginal mucosa and mucosa, vaginitis clinically taking the character of leucorrhea change and pruritus vulvae causalgia as main clinical characters, sexual anhedonia is also common, when urethra is involved in infection, can there is the symptom such as dysurea, urgent micturition, bring very large worries to patient's live and work.Common vaginitis has bacterial vaginitis, trichomonal vaginitis, colpitis mycotica, senile vaginitis.
Bacterial vaginitis is that Gardnerella, various anaerobe, bending vibrio etc. are main a kind of mixed infection.Colpitis mycotica is to be caused by fungal infections such as Candida albicans.Trichomonal vaginitis is trichomonal a kind of vaginitis per vaginam.
Middle-aged women is suffered from vaginitis, not only can occur Simple infection vaginitis, and mixed infective vaginitis also can occur, as: the vaginitis of Candida albicans, anaerobe, infusorian property, haemophilus, two or more concurrent infections of corynebacterium.Mixed infective vaginitis state of an illness more complicated, treatment needs comprehensive medication, but lack clinically at present that a kind of mastic granularity is little, even, fine and smooth, denseness is suitable, be easy to be coated on the portable compound preparation on the focus mucosa of vagina, meet patient's Comprehensive Treatment demand.
Object of the present invention is exactly to prepare that a kind of mastic granularity is little, even, fine and smooth, denseness is suitable, be easy to be coated on the portable compound preparation on the focus mucosa of vagina, meets patient treatment demand.According to the study, 5-nitro glyoxaline antibiotic, has obvious therapeutic effect to anaerobe and trichomonal vaginitis; Triazole antifungal agent has good killing action to vagina Candida albicans, cationic germicide, and has a broad antifungal spectrum, has killing action to most Grain-positives and negative bacteria.Therefore the colpitic compound ointment preparation for the treatment of of the present invention, is defined as 5-nitro glyoxaline antibiotic by principal agent A, and principal agent B is defined as triazole antifungal agent, and principal agent C is defined as cationic germicide.In order to allow, mastic granularity is little, even, fine and smooth, denseness is suitable, be easy to be coated on the focus mucosa of vagina, and the present invention has taked particular substrate supplementary product kind and ratio, special portable medicine feeding machine, and special preparation technique.
Ointment of the present invention is made up of the component of following weight percentage, principal agent A (principal agent A is the one in 5-nitro glyoxaline antibiotic) 5%, principal agent B (principal agent B is the one in triazole antifungal agent) 4%, principal agent C (principal agent C is the one in cationic germicide) 0.2%, (substrate adjuvant is carboxymethyl starch sodium 5% to substrate adjuvant, sodium carboxymethyl cellulose 0.3%, glycerol 20%, purified water 65.5%).
Ointment of the present invention is to prepare by special process below:
1,, by principal agent A (principal agent A is the one in 5-nitro glyoxaline antibiotic) 5%, principal agent B (principal agent B is the one in triazole antifungal agent) 4%, pulverizes with pulverizer, cross 100 mesh sieves, fine powder packs in clean plastic bag, after tightening, put into stainless steel cask, stand-by.
2,, by purified water 65.5%, be heated to 40 DEG C-80 DEG C.By principal agent C (principal agent C is the one in cationic germicide) 0.2%, add in above-mentioned purified water, fully stir, it is dissolved completely, become settled solution, and to keep solution temperature be 40 DEG C-80 DEG C.
3, by the principal agent A5% in 1, principal agent B4%, sodium carboxymethyl cellulose 0.3%, puts in mixer, mixes 30-90 minute, obtains uniform mixed powder.
4, by glycerol 20%, slowly add in 2 solution, stir while adding, mix homogeneously, obtains settled solution.
5, by carboxymethyl starch sodium 5%, slowly sow in a small amount of 4 solution to grind and infiltrate, more slowly add in 4 solution in batches, stir while adding, make it become homogeneous slurry, continue to stir, and slow cooling to 20 DEG C-25 DEG C.
6, by the mixed powder in 3, slowly join in the thickness paste substrate in 5, stir while adding.Mixing speed is 50-80 rev/min, after all adding, takes batch type.Front stirring respectively for twice 10 minutes, leaves standstill 5 minutes; Stir for the 3rd time after 10 minutes, leave standstill 90 minutes, make it fully swelling; Then stir 30 minutes, leave standstill 10 minutes; Stir again 5 minutes, leave standstill 10 minutes; Continue to be stirred to material in tank and become thick mastic, then after colloid mill grinds, sealing and standing 16-72 hour.
7, medicine feeding machine is carried out to inside and outside wall sterilization.Column top is plugged in pencil fixed position, by the mastic in 6, is distributed in medicine feeding machine's pencil, with pipe cap sealing, plastic packaging, then with the band handle top bolt mounted box of independent plastic packaging, to obtain final product.
Advantage of the present invention is:
For the treatment feature of mixed infective vaginitis, ointment of the present invention is by the component of following weight percentage, prepare by special process program and special exterior and interior packing, the mastic granularity of this ointment is little, evenly, fine and smooth, denseness is suitable, be easy to be coated on the focus mucosa of vagina, increase drug release solution absorption, and nonirritant, improve medicine pharmacological action, improve the safety of medication, more portable while making patient go out to be with medicine, the uncomfortable sensation such as pain while having removed patient's vagina administration, improve medication comfortableness, improve Treatment Compliance, shorten treatment cycle.
Embodiments of the invention:
As shown in Figure 1, it has a pencil 2 to said portable medicine feeding machine, in pencil 2, ointment is housed, elastic packing pipe cap 1 is equipped with on pencil 2 tops, and column top plug 4 is equipped with at pencil 2 rear portions, has a groove with the side of handle top bolt 5, and independent packaging, disposable body lotion 6 independent packagings.Before perfusion ointment, by the whole sterilizations of above-mentioned article inside and outside wall, and column top plug 4 is placed in to assigned position, according to loading amount, ointment is poured in pencil 2, then seal pencil 2 front ends with pipe cap 1, aluminum-plastic packaged.Used time is taken out the band handle top bolt 5 of independent packaging, be assembled in pencil 2 rear portions, pipe cap 1 is pulled out, the body lotion of independent packaging 6 is extruded, painting is opened up in pencil 2 outer walls, pencil 2 is sent into gently to the affected area of vagina, push belt handle top bolt 5 takes out medicine feeding machine and abandons it after ointment is all injected.Two drawbacks of current medicine feeding machine are so just solved: (1) is because medicine feeding machine's pipe shaft is long at present, patient is in the time going out, carrying medicine does not put just, medicine feeding machine in the present invention, because band handle top bolt 5 is independent packagings, just medicine feeding machine's entire length is foreshortened to half, facilitated patient to carry.(2) while using current medicine feeding machine's administration, a lot of patients can feel pudendum pain or uncomfortable, the body lotion 6 in the present invention, the discomfort sensation while just having removed patient's medication.
Fig. 1 is portable medicine feeding machine's of the present invention schematic diagram
The 1st, elastic packing pipe cap
The 2nd, pencil
The 3rd, ointment
The 4th, column top plug
The 5th, band handle top bolt
The 6th, disposable body lotion.
Claims (3)
1. the colpitic compound ointment preparation prescription for the treatment of, portable medicine feeding machine and preparation method thereof, feature of the present invention is, preparation is by the component of following weight percentage, prepare by special process program and special exterior and interior packing: principal agent A (principal agent A is the one in 5-nitro glyoxaline antibiotic) 5%, principal agent B (principal agent B is the one in triazole antifungal agent) 4%, principal agent C (principal agent C is the one in cationic germicide) 0.2%, (substrate adjuvant is carboxymethyl starch sodium 5% to substrate adjuvant, sodium carboxymethyl cellulose 0.3%, glycerol 20%, purified water 65.5%).Above-mentioned material was pulverized to 100 mesh sieves by special process, dosing, preparation ointment, is sealed in the ointment of making in portable medicine feeding machine of the independent packaging through inside and outside wall sterilizing that meets human physiological structure.
2. according to the said compound ointment preparation method of claim 1, it is characterized in that:
2.1, by principal agent A (principal agent A is the one in 5-nitro glyoxaline antibiotic) 5%, principal agent B (principal agent B is the one in triazole antifungal agent) 4%, pulverizes with pulverizer, cross 100 mesh sieves, fine powder packs in clean plastic bag, after tightening, put into stainless steel cask, stand-by.
2.2,, by purified water 65.5%, be heated to 40 DEG C-80 DEG C.By principal agent C (principal agent C is the one in cationic germicide) 0.2%, add in above-mentioned purified water, fully stir, it is dissolved completely, become settled solution, and to keep solution temperature be 40 DEG C-80 DEG C.
2.3, by the principal agent A5% in 2.1, principal agent B4%, sodium carboxymethyl cellulose 0.3%, puts in mixer, mixes 30-90 minute, obtains uniform mixed powder.
2.4, by glycerol 20%, slowly add in 2.2 solution, stir while adding, mix homogeneously, obtains settled solution.
2.5, by carboxymethyl starch sodium 5%, slowly sow in a small amount of 2.4 solution to grind and infiltrate, more slowly add in 2.4 solution in batches, stir while adding, make it become homogeneous slurry, continue to stir, and slow cooling to 20 DEG C-25 DEG C.
2.6, by the mixed powder in 2.3, slowly join in the thickness paste substrate in 2.5, stir while adding, mixing speed is 50-80 rev/min, after all adding, takes batch type, front stirring respectively for twice 10 minutes leaves standstill 5 minutes; Stir for the 3rd time after 10 minutes, leave standstill 90 minutes, make it fully swelling; Then stir 30 minutes, leave standstill 10 minutes; Stir again 5 minutes, leave standstill 10 minutes; Continue to be stirred to material in tank and become thick mastic, then after colloid mill grinds, sealing and standing 16-72 hour.
2.7, medicine feeding machine is carried out to inside and outside wall sterilization, column top is plugged in pencil fixed position, by the mastic in 2.6, be distributed in medicine feeding machine's pencil, by pipe cap sealing, aluminium-plastic sealing packaging, then with the band handle top bolt mounted box of independent aluminium-plastic sealing, to obtain final product.
3. according to the said compound ointment of claim 1, be sealed in medicine feeding machine, above-mentioned medicine feeding machine's feature is: medicine feeding machine is accompanied with the human body lubricants that meets hygienic requirement, medicine feeding machine is by pencil, pipe cap, column top plug, band handle top bolt forms, it is circular-arc that pencil front end is round and smooth closing in, and there is an insecticide-spraying hole, elastic packing pipe cap is contained in pencil front end, column top plugs in pencil rear portion, diameter with handle top bolt is consistent with column top plug, there is a groove side, and independent packaging, above-mentioned medicine feeding machine is all carried out to inside and outside wall sterilizing, aseptic packaging, and meet hygienic requirement, when use, be with handle top bolt to be assembled on pencil, human body lubricants is coated with to exhibition on pencil outer wall, pencil is sent into gently to the affected area of vagina, push belt handle top bolt, after ointment is all injected, take out medicine feeding machine and abandon it.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310089149.7A CN104056272A (en) | 2013-03-20 | 2013-03-20 | Prescription, delivering device and preparation method for compound ointment used for treating colpitis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310089149.7A CN104056272A (en) | 2013-03-20 | 2013-03-20 | Prescription, delivering device and preparation method for compound ointment used for treating colpitis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104056272A true CN104056272A (en) | 2014-09-24 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310089149.7A Pending CN104056272A (en) | 2013-03-20 | 2013-03-20 | Prescription, delivering device and preparation method for compound ointment used for treating colpitis |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104056272A (en) |
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2013
- 2013-03-20 CN CN201310089149.7A patent/CN104056272A/en active Pending
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Application publication date: 20140924 |