CN104039338A

CN104039338A - Botanical Antimicrobial Composition

Info

Publication number: CN104039338A
Application number: CN201280064657.3A
Authority: CN
Inventors: 尚达·M·莫达克; 圣多许库玛尔·东瑞; 劳什皮纳·卡劳斯; 纳亚那·拜丘; 哈里·喀许南·拉玛千兰
Original assignee: Columbia University in the City of New York
Current assignee: Columbia University in the City of New York
Priority date: 2011-11-03
Filing date: 2012-05-09
Publication date: 2014-09-10
Also published as: CA2890395A1; AU2012333187A1; IN2014CN04034A; CA2890395C; EP2775847A1; WO2013066403A1; EP2775847A4; JP2015501330A

Abstract

Disclosed are compositions comprising antimicrobially effective low concentrations of benzyl alcohol, one or more essential oil and one or more botanical extract. The compositions of the application may be used in personal care products including wound care products or in veterinary use. In certain embodiments, compositions are provided having antimicrobial active agents that are substantially or essentially entirely derived from natural sources, thereby allowing the user to avoid harsh and/or toxic chemicals. This may be particularly advantageous in products for use by or on children or pets or for use in households or other environments occupied by children or animals.

Description

Vegetalitas antimicrobial compositions

Prioity claim

The application is the U.S. Patent application 13/412 of submitting on March 5th, 2012, 464 part continuation application, require the priority of following U.S. Provisional Application: the U.S. Provisional Application 61/555 that on November 3rd, 2011 submits to, 367, the U.S. Provisional Application 61/567 of December in 2011 submission on the 6th, 372, the U.S. Provisional Application 61/583 that on January 5th, 2012 submits to, 482, the U.S. Provisional Application 61/583 that on January 5th, 2012 submits to, 505, and the U.S. Provisional Application 61/583 of submission on January 6th, 2012, 998, the application requires the priority of above each application, the full content of each application is incorporated to herein by reference above.

Technical field

The application discloses and has contained the effectively compositions of antibacterial combination of benzyl alcohol, quintessence oil and plant extract (comprising plant extract and fruit extract).

Background technology

Quintessence oil is the volatile oil obtaining from plant source or animal sources, has Multiple components, the complex mixture composition of such as monoterpene and sesquiterpene hydro carbons, monoterpene and sesquiterpene alcohols, esters, ethers, aldehydes, ketone, oxide etc.These quintessence oils and separated component thereof are usually used as spice and flavoring agent, and are widely used in the folk medicine healing a wound.

Scientific research is the verified beneficial effect of quintessence oil.It is found that Eucalyptus quintessence oil " has maincenter and periphery analgesic effect and dependence or do not rely on the antiphlogistic activity of neutrophil cell " (Silva etc., 2003, J.Ethnopharmacol.89 (2-3); 277-283), in the quintessence oil from lavandula angustifolia, observe similar activity (Hajhashemi etc., 2003, J.Ethnopharniacol.89 (1): 67～71).Prove on evidence quintessence oil has antibacterial (Bezic etc., 2003, Phytother.Res.17 (9:1037-1040; Goren etc., 2003, Z.Naturforsch.58 (9-10): 687-690; De Abreu Gonzaga etc., 2003, Planta Med.69 (8:773-775; Valero and Salmera, 2003, Int.J.Food Microbiol.85 (1-2): 73-81) and antifungal (Paranagama etc., 2003, Lett.Appl.Microbiol.37 (l); 86-90; Shin, 2003, Arch.Pharm.Res.26 (5): 389-393; Velluti etc., 2003, Int.J.Food Microbiol.89:145-154) activity.Also observe the antiviral activity of quintessence oil, comprised direct antiviral effect (Garcia etc., Phytother.Res.17 (9): 1073-1075 to 1 type and herpes simplex types 2 virus; Minami etc., 2003, Microbial Immunol.47 (a): 681-684; Schuhmacher etc., 2003, Phytomedicine10:504-510).

Publication number is that 20050048139 U.S. Patent application (is announced on March 3rd, 2005, invention Ren Wei Mo Dake etc.) relate to the topical compositions that contains lubricant and quintessence oil, said composition also contains other additive, for example citric acid, glycolic and lactic acid.

Publication number is that 20050019431 U.S. Patent application (announcing invention Ren Wei Mo Dake etc. on January 27th, 2005) relates to the compositions that contains quaternary ammonium compound and quintessence oil (or its active component).

The compositions that has a large amount of patent applications to relate to contain quintessence oil (or its composition), in these compositionss, has added the pain of zinc salt to prevent from being caused by quintessence oil.The example of these patent applications comprises that publication number is that 2004102429 U.S. Patent application (is announced on May 27th, 2004, invention Ren Wei Mo Dake etc.) and publication number be 20050238602 U.S. Patent application (is announced on October 27th, 2005, invention Ren Wei Mo Dake etc.) and the United States Patent (USP) 7 announced at that time, 435,429.

United States Patent (USP) 6,858,317 (issue on February 22nd, 2005, invention people is Aamodt etc.) relate to the nontoxic mould inhibitor of use and prevent that timber is subject to the method for mycete and sap stain fungal infection, described nontoxic mould inhibitor can be plant extract, for example quintessence oil.

United States Patent (USP) 5,100,652 (issue on March 31st, 1992, invention people is Kross etc.) relate to the low concentration chlorous acid that forms oral hygiene composition, and it contains the quintessence oil as flavoring agent.

United States Patent (USP) 5,310,546 (issue on May 10th, 1994, invention people is Douglas) relate to a kind of collutory, it contains hydrogen peroxide, zinc chloride, sodium citrate, sodium lauryl sulfate, citric acid and ethanol, also can select to add quintessence oil as denaturant.

BION provides several parts skin nursing products, and it contains citric acid, galenical and other preparations (California, USA San Diego).

Johnson etc. (United States Patent (USP) 6,319,958 and US Patent No. 20020165130) relate to the picked-up that adopts sesquiterpenoid to promote exogenous Antimicrobe compound.Similarly, one section of relevant paper has been pointed out employing sesquiterpenoid, as the susceptibility of nerolidol, farnesol, bisabolol and A Puli ketone (apritone) raising bacterial penetration and exogenous Antimicrobe compound, show that sesquiterpenoid has non-specific and general effect (Brehm-Stecher etc., Antimicrobial Agents and Chemotherapy, 47 (10): 3357-3360).Specifically, the report of Brehm-Stecher etc. proposes, and nerolidol, farnesol, bisabolol and A Puli ketone have improved the susceptibility of staphylococcus aureus to antibiotic erythromycin, gentamycin, vancomycin, ciprofloxacin (ciproflaxin), clindamycin and tetracycline.

United States Patent (USP) 4,867,898 (issue for 19th in JIUYUE in 1989, invention people is Spaulding etc.) relate to a kind of crust liquid cleaner, and it contains the oil-soluble organic acid that Pinaster oil and pH value are 0-6.

United States Patent (USP) 6,753,305 (issue on June 22nd, 2004, invention people is Raso and Caselli) relate to a kind of crust disinfectant, it contains nearly the organic acid of 20% Oleum Cinnamomi or its a kind of composition, 0.01-5%, and alternative other quintessence oils that add.

Publication number is that the international patent application of WO2007077573 (is announced on July 12nd, 2007, invention people is Mukhopadhyay) relate to antimicrobial compositions, the antimicrobial that it contains a kind of for example triclosan and functionalized hydrocarbon and/or solvent, wherein, functionalized hydrocarbon can be a kind of quintessence oil.

Infection remains the subject matter of processing in patient burn wound, decubital ulcer and other surface infections.It is of paramount importance in preventing antibacterial mass formed by blood stasis and promoting wound healing, controlling skin infection.Develop local application's cream and other part antimicrobial that contains silver sulfadiazin and be widely used in above-mentioned purpose.But the use of these preparations does not reach controls target infection completely.

As prevention ointment, 1% silver sulfadiazin emulsifiable paste is used for controlling Burn Infection effectively.But because medicine can not infiltrate wound eschar, the deep infection effect that it has formed for treatment is not very effective.Using in the patient who treats, have wound by the generation of staphylococcus aureus and Candida albicans infection, this impels us to have to develop the research of other preparation.

Verified, the Sustainable Control infecting is conducive to quickly-healing and the sealing of II degree burn, decubital ulcer and other types traumatic surface.Wound healing, especially burn wound healing, be a complicated process, has been found that zinc has important function in this process.Research for zinc shows, zinc can accelerate reepithelialization process, and wound healing is had to beneficial effect, and has antibacterial effect.Have report to claim, zinc can activate endogenous zinc and rely on matrix metalloproteinase, strengthens the expression of Endogenous Growth Factors and promote the migration of keratinocyte.

In research, find in early days, use zinc sulfadiazine to carry out surface treatment to burn wound and accelerating to be better than silver sulfadiazin (Gyn and Obstet, 142:553-559 (1976)) aspect wound healing.

Prevent or reduced Burn Infection with ointment with local.These ointment contain silver sulfadiazin (United States Patent (USP) 3761590 is incorporated to herein by reference) or various antibiotic.It is reported have a kind of part ointment also to contain the combination (United States Patent (USP) 4404197 is incorporated to herein by reference) of silver salt and norfloxacin, quinolin antibiotic or its salt.In the time that antibiotic is norfloxacin silver, active collaborative enhancing of United States Patent (USP) 4404197 report.United States Patent (USP) 5374432 relates to the part of containing antibiotic, silver salt and sterile carrier infection ointment.These compositionss not only have improved antibiotic effect, have also reduced the occurrence probability of microorganisms resistance.

United States Patent (USP) 6987133 relates to a kind of topical preparation of containing silver sulfadiazin, and described silver sulfadiazin scatters or is dissolved in the emulsifiable paste or washing liquid substrate that can directly be applied in burn wound.European patent EP 0653214 relates to a kind of part antibiotic preparation that contains silver sulfadiazin and collagen protein, is used for the treatment of hand infection and promotes its healing.

In various specialties and amateur application, need a kind of reusable nonirritant, safety and antimicrobial mixtures or Wound healing compositions always.

Summary of the invention

The invention discloses the compositions that contains effective antimicrobial Low Concentration of Benzene methanol, one or more quintessence oils and one or more plant extracts, in certain embodiments, compositions has the overwhelming majority or substantially all comes from the antimicrobial activities of natural resources, therefore, avoid user to use zest and/or toxic chemical substance.This benefits especially child or house pet and uses, or in the family or other have in the environment of child or house pet and use.

In certain embodiments, antimicrobial compositions contains benzyl alcohol (approximately 0.1% (weight ratio) is to 10% (weight ratio)), one or more quintessence oils are such as but not limited to lemongrass oil, Oleum Cinnamomi, thyme oil, Rhizoma Alpiniae Officinarum oil, orange oil, Punica granatum L. oil, curry leaf oil, and their combination (approximately 0.02% (weight ratio) is to 1.0% (weight ratio)), and for example Wasabia japonic (Euterma Wasabi) extract of one or more plant extracts, grapefruit seed extract, Flos Lonicerae extract, cedar wood extract, Punica granatum L. extract, purple coneflower extract, aspen bark extract, extract of willow bark, Citrus extract, Khalid Boulami (Brahmi) extract, and their combination (approximately 0.1% (weight ratio) is to 1.0% (weight ratio)).Selectivity adding ingredient comprises such as farnesol of one or more sesquiterpenes, nerolidol, bisabolol, A Puli ketone (apritone), citral, and their combination (approximately 0.03% (weight ratio) is to 2% (weight ratio)), one or more vegetalitas alcohol (approximately 5% (weight ratio) is to 20% (weight ratio)), such as fruit acid of one or more natural organic acidss, benzoic acid, salicylic acid, and their combination (0.02% (weight ratio) is to 2.0% (weight ratio)), and vegetable glycerol.

Term " about " used herein refers to enumerator ± 20%.

All scopes herein comprise enumerator.

In some non-limiting example, antimicrobial compositions comprises:

(a) approximately 0.5% (weight ratio) is to 50% (weight ratio) benzyl alcohol;

(b) approximately 0.01% (weight ratio) is to 5% (weight ratio) quintessence oil; And

(c) approximately 0.1% (weight ratio) be to 4% (weight ratio) sesquiterpene,

Wherein, described compositions does not comprise alkane glycol.

In some non-limiting example, antimicrobial compositions comprises:

(a) approximately 0.5% (weight ratio) is to 50% (weight ratio) benzyl alcohol;

(b) approximately 0.01% (weight ratio) is to 5% (weight ratio) quintessence oil;

(c) approximately 0.5% (weight ratio) is to 10% (weight ratio) plant extract, and described plant extract selects the set of freely following material composition: Wasabia japonic (Euterma Wasabi) extract, Flos Lonicerae extract, cedar wood extract, aspen bark extract, extract of willow bark, tobacco extract and their combination.

In some non-limiting example, antimicrobial compositions comprises:

(a) approximately 0.5% (weight ratio) is to 50% (weight ratio) benzyl alcohol;

(c) approximately 0.5% (weight ratio) is to 10% (weight ratio) plant extract;

(d) approximately 0 to 20% (weight ratio) fruit acid;

(e) approximately 0.1% (weight ratio) be to 4% (weight ratio) sesquiterpene,

Wherein, described compositions does not comprise alkane glycol.

In some non-limiting example, antimicrobial compositions comprises:

(a) approximately 0.5% (weight ratio) is to 2.0% (weight ratio) benzyl alcohol;

(b) approximately 0.5% (weight ratio) is to 4.0% (weight ratio) specific cation complex (incroquat);

(c) approximately 0.2% (weight ratio) is to 0.5% (weight ratio) benzoic acid;

(d) approximately 0.05% (weight ratio) is to one or more quintessence oils of 1% (weight ratio), and described quintessence oil selects the set of freely following material composition: Herba Origani oil, thymol, oil of rosemary, Oleum Cinnamomi (for example Cortex Cinnamomi leaf oil or Oleum Cinnamomi), Rhizoma Alpiniae Officinarum oil, Punica granatum L. oil and lemongrass oil; And

(e) approximately 0.2% (weight ratio) is to one or more plant extracts of 2.0% (weight ratio), and described plant extract selects the set of freely following material composition: Wasabia japonic (Euterma Wasabi) extract, grapefruit extract, Citrus reticulata Blanco extract, Flos Lonicerae extract, Aloe gel and Folium Aloe juice.In some subset of the present embodiment, described compositions also comprises the zinc oxide of approximately 0.1% (weight ratio) to 0.5% (weight ratio).In some subset of the present embodiment, described compositions also comprises the sodium benzoate of approximately 0.2% (weight ratio) to 0.5% (weight ratio).In some subset of the present embodiment, described compositions also comprises the pentanediol of approximately 0.1% (weight ratio) to 1.0% (weight ratio).In some subset of the present embodiment, described compositions also comprises grapefruit seed or another kind of Citrus reticulata Blanco extract, and for example, its concentration is about 0.3% (weight ratio) to 1.0% (weight ratio).In some subset of the present embodiment, described compositions also comprises one or more vitamin Es and/or vitamin C, and for example, each concentration is about 0.02% (weight ratio) to 0.2% (weight ratio).In some subset of the present embodiment, described compositions also comprises sesquiterpene or sesquiterpene mixture, for example, and when its concentration is about 0.3% (weight ratio) to 2.0% (weight ratio).In some subset of the present embodiment, described compositions is not included as antibacterial or the antibacterial of biguanide, chlorophenol or quaternary ammonium compound.In some subset of the present embodiment, described compositions does not comprise phenylethanol.In some subset of the present embodiment, described compositions does not comprise phenoxyethanol.In some subset of the present embodiment, described compositions does not comprise polymyxin, miconazole, fluconazol, Yi Kang azoles (itriconazole) or ketoconazole.In some subset of the present embodiment, described compositions does not comprise neomycin.In some subset of the present embodiment, described compositions does not comprise bacitracin.In some subset of the present embodiment, described compositions does not comprise povidone iodine or other are containing iodine compound.

In some non-limiting example, antimicrobial compositions comprises:

(a) approximately 0.1% (weight ratio) is to 2.0% (weight ratio) benzyl alcohol;

(b) approximately 0.1% (weight ratio) is to 2.0% (weight ratio) benzoic acid;

(c) approximately 0.5% (weight ratio) is to 1.0% (weight ratio) phenoxyethanol;

(d) approximately 0.3% (weight ratio) is to 1.3% (weight ratio) sesquiterpene, and its form is single sesquiterpene or sesquiterpenoids mixture;

(e) approximately 0.05% (weight ratio) is to one or more quintessence oils of 2.5% (weight ratio), and described quintessence oil selects the set of freely following material composition: Herba Origani oil, thymol, oil of rosemary, Oleum Cinnamomi (for example Cortex Cinnamomi leaf oil or Oleum Cinnamomi), Rhizoma Alpiniae Officinarum oil, Punica granatum L. oil and lemongrass oil; And

(f) approximately 0.2% (weight ratio) is to one or more galenicals of 2.0% (weight ratio), and described galenical selects the set of freely following material composition: Wasabia japonic (Euterma Wasabi) extract, grapefruit extract, Citrus reticulata Blanco extract, Flos Lonicerae extract, Aloe gel and Folium Aloe juice.In some subset of the present embodiment, described compositions also comprises the pentanediol of approximately 0.5% (weight ratio) to 3.0% (weight ratio).In some subset of the present embodiment, described compositions also comprises the cationic surfactant of approximately 0.5% (weight ratio) to 2.0% (weight ratio).In some subset of the present embodiment, described compositions is not included as antibacterial or the antibacterial of biguanide, chlorophenol or quaternary ammonium compound.In some subset of the present embodiment, described compositions does not comprise phenylethanol.In some subset of the present embodiment, described compositions does not comprise polymyxin, miconazole, fluconazol, Yi Kang azoles (itriconazole) or ketoconazole.In some subset of the present embodiment, described compositions does not comprise neomycin.In some subset of the present embodiment, described compositions does not comprise bacitracin.In some subset of the present embodiment, described compositions does not comprise povidone iodine or other are containing iodine compound.

In some non-limiting example, antimicrobial compositions comprises:

(a) approximately 0.1% (weight ratio) is to 2.0% (weight ratio) benzyl alcohol;

(b) approximately 0.02% (weight ratio) is to 2.0% (weight ratio) benzoic acid;

(c) approximately 0.1% (weight ratio) is to 1.0% (weight ratio) phenylethanol;

(d) approximately 0.02% (weight ratio) is to 1% (weight ratio) sesquiterpene, and its form is single sesquiterpene or sesquiterpenoids mixture;

(f) approximately 0.05% (weight ratio) is to one or more galenicals of 2.0% (weight ratio), and described galenical selects the set of freely following material composition: Wasabia japonic (Euterma Wasabi) extract, grapefruit extract, Citrus reticulata Blanco extract, Flos Lonicerae extract, Aloe gel and Folium Aloe juice.In some subset of the present embodiment, described compositions is not included as antibacterial or the antibacterial of biguanide, chlorophenol or quaternary ammonium compound.In some subset of the present embodiment, described compositions does not comprise phenoxyethanol.In some subset of the present embodiment, described compositions does not comprise polymyxin, miconazole, fluconazol, Yi Kang azoles (itriconazole) or ketoconazole.In some subset of the present embodiment, described compositions does not comprise neomycin.In some subset of the present embodiment, described compositions does not comprise bacitracin.In some subset of the present embodiment, described compositions does not comprise povidone iodine or other are containing iodine compound.

In some non-limiting example, disinfectant comprises:

(a) approximately 0.5% (weight ratio) is to 3.0% (weight ratio) benzyl alcohol;

(b) approximately 0.05% (weight ratio) is to 2.5% (weight ratio) lemongrass oil, orange oil or their combination;

(c) approximately 0.1% (weight ratio) is to 2.0% (weight ratio) fruit acid;

(d) approximately 0.1% (weight ratio) is to 2.0% (weight ratio) galenical, and described galenical selects the set of free Wasabia japonic (Euterma Wasabi) extract and Flos Lonicerae extract composition.

In some non-limiting example, Wound healing compositions comprises:

(a) approximately 0.1% (weight ratio) is to 0.5% (weight ratio) benzyl alcohol;

(b) approximately 0.2% (weight ratio) is to 1.0% (weight ratio) zinc oxide;

(c) approximately 0.05% (weight ratio) is to 0.7% (weight ratio) curcumin; And

(d) in following material at least two kinds: Punica granatum L. oil, oil of rosemary, lemongrass oil, Oleum Cinnamomi (for example Cortex Cinnamomi leaf oil or Oleum Cinnamomi), thymol and Phamnus cathartica L. oil, every kind of content of material approximately 0.1% (weight ratio) is to 1.0% (weight ratio).

In some non-limiting example, surface disinfectant comprises:

(a) approximately 1.0% (weight ratio) is to 30% (weight ratio) benzyl alcohol;

(b) approximately 0.1% (weight ratio) is to Pinaster oil and the blend of essential oils of 4.0% (weight ratio), and described quintessence oil selects the set of freely following material composition: lemongrass oil, orange oil, Cortex Cinnamomi leaf oil, Oleum Cinnamomi and their combination;

(c) approximately 2% (weight ratio) is to 10% (weight ratio) fruit acid;

(d) approximately 5% (weight ratio) is to 25% (weight ratio) surfactant; And

(e) water; Selectively, also comprise 3% (weight ratio) to 50% (weight ratio) fatty alcohol (for example, for example, such as but not limited to fatty alcohol mixture, ethanol and propanol or butanols mixture, SDA3C or SDA40B).

In some non-limiting example, surface disinfectant comprises:

Approximately 2.5% (weight ratio) is to 10% (weight ratio) quintessence oil, and described quintessence oil selects the set of freely following material composition: lemongrass oil, orange oil, Cortex Cinnamomi leaf oil, Oleum Cinnamomi and their combination;

Approximately 0.5% (weight ratio) is to 5.0% (weight ratio) Pinaster oil;

Approximately 25% (weight ratio) is to 50% (weight ratio) surfactant;

Approximately 10% (weight ratio) is to 20% (weight ratio) fruit acid;

Approximately 20% (weight ratio) is to 40% (weight ratio) fatty alcohol; And water.

In some non-limiting example, a kind of Cleasing compositions comprise approximately 1% (weight ratio) to 5% (weight ratio) lemongrass oil, approximately 0.1% (weight ratio) to 1% (weight ratio) Pinaster oil and approximately 5% (weight ratio) to 20% (weight ratio) citric acid.

In different non-limiting examples, described compositions can be applicable to personal care product, Wound care products, burn wound's cream, band bed sore ointment (contain antiinflammatory galenical and use silver sulfadiazin as antimicrobial), quick-acting skin antiseptic, disinfecting towel and the products for animals such as such as soap, facial milk cleanser, cosmetics, medicinal external emulsifiable paste and washing liquid, for example, be used for the treatment of antimicrobial washing liquid, teat dip and the treatment ointment of mastitis.The working concentration of the present composition in personal care product or topical cream is about 1% to 10%.In other non-limiting examples, described compositions can be used in family and commercial Application, for example surfactant, surface cleaner, insecticide and antiseptic.

Detailed description of the invention

For the purpose of being described clearly, but the application's detailed description of the invention is divided into following components by also unrestricted the present invention:

(4.1) benzyl alcohol;

(4.2) quintessence oil;

(4.3) plant extract;

(4.4) sesquiterpene;

(4.5) alkane glycol;

(4.6) solvent;

(4.7) natural organic acids;

(4.8) personal care product;

(4.9) wound healing;

(4.10) product for animals;

(4.11) family/industrial products;

(4.12) armarium; And

(4.13) insecticide

4.1 benzyl alcohol

Compositions disclosed herein comprises benzyl alcohol, concentration (% (w/w), " % (W/W) ") be about 0.05% (W/W) to 60% (W/W), or approximately 0.5% (W/W) to 50% (W/W), or approximately 0.5% (W/W) is to 50% (W/W), or approximately 0.5% (W/W) is to 2.0% (W/W), or approximately 0.1% (W/W) is to 2.0% (W/W), or approximately 0.1% (W/W) is to 0.5% (W/W), or approximately 0.5% (W/W) is to 5% (W/W), or approximately 5.0% (W/W) is to 20% (W/W), include but not limited to be about 0.05% (W/W), 0.1% (W/W), 0.5% (W/W), 1.0% (W/W), 2.0% (W/W), 3.0% (W/W), 4.0% (W/W), 5.0% (W/W), 6.0% (W/W), 7.0% (W/W), 8.0% (W/W), 9.0% (W/W), 10.0% (W/W), 12% (W/W), 15% (W/W), 18% (W/W), 20% (W/W), 25% (W/W), 30% (W/W), 35% (W/W), 40% (W/W), 45% (W/W), 50% (W/W), 55% (W/W) and 60% (W/W).

In some non-limiting example, compositions disclosed herein comprises benzyl alcohol, and concentration is about 0.1 to 0.5%w/w; Or be about 0.1 to 0.45%w/w; Or be about 0.1 to 0.4%w/w; Or be about 0.1 to 0.35%w/w; Or be about 0.1 to 0.3%w/w; Or be about 0.1 to 0.25%w/w; Or be about 0.1 to 0.2%w/w; Or be about 0.1 to 0.15%w/w.

The benzyl alcohol that compositions disclosed herein is used can be made or be obtained by one or more natural plants (vegetalitas) source by synthetic method.

4.2 quintessence oil

Quintessence oil as herein described (" EO ") is the volatile oil available from plant or animal origin, or its synthetic equivalent, by Multiple components, as monoterpene and sesquiterpene hydro carbons, the complex mixture composition of monoterpene and sesquiterpenoid, ester, ether, aldehyde, ketone, oxide etc.The example of EO includes but not limited to: Oleum Cinnamomi (for example Cortex Cinnamomi leaf oil or Oleum Cinnamomi), basil oil, oleum bergamottae, Salvia Sclare L.oil, Cananga odorata oil, orange blossom oil, sandalwood oil, frankincense oil, oil of ginger, Oleum menthae, Oleum lavandula angustifolia, Jasmin oil, Oleum Pelargonii Graveolentis bourbon, Oleum Menthae Rotundifoliae, Oleum Caryophylli, patchouli oil, oil of rosemary, rosewood oil, sandalwood oil, tea tree oil, Rhizoma et radix valerianae oil, lemongrass oil, Herba Origani oil, thymol, Rhizoma Alpiniae Officinarum oil, cedarwood oil, face cream tree oil, tangerine oil, flat Cedrus deoclar (Roxb.) G. Don oil, oil, last of the twelve Earthly Branches bar oil (Hiba oil), ginkgo oil (ginko oil), press leaf oil, Fructus Citri Limoniae oil, orange oil, oleum Citri sinensis, granada seed oil, Punica granatum L. oil, manuka oil, citronella oil, curried leaf oil and Flos Inulae oil.

The single composition (" IC ") of quintessence oil can separate from (natural) oil, or chemosynthesis wholly or in part, include but not limited to: Herba thymi vulgaris, Adeps Bovis seu Bubali, curcumin, 1-citronellol, jasminal, LYRAL (lyral), geraniol, farnesol, hydroxycitronellal, isoeugenol, acetaminol, Camphora, eucalyptole, linalool, citral, thymol, limonene and menthol.Other examples of IC comprise sesquiterpenoid, and they can be the reactive compounds in quintessence oil.Form from 3 5-carbon isoprene units the sesquiterpenoid that contains 15 carbon by biosynthesis.Sesquiterpenoid includes but not limited to: farnesol, the tertiary orange of orange blossom, bisabolol, A Puli ketone, chamazulene, santalol, zingiberol, carotenol and caryophyllene.

The present invention includes mixture, one or more EO and one or more IC of one or more EO and one or more IC.In some concrete non-limiting example of the present invention, the set (non-limiting) of the freely following material composition of IC choosing: Camphora, curcumin, australene, Cortex Cinnamomi leaf oil component be cinnamic aldehyde, cinnamoyl acetas, cinnamic acid, ethyl cinnamate, methyl chavicol, linalool, β-caryophyllene and eugenol for example; Lemongrass oil component is d-limonene, geranyl acetate, nerol, geraniol, citral and/or myrcene for example; Citronella oil component is geraniol, citronellol, citronellal, geranyl acetate, limonene, methylisoeugenol and/or elemol for example; Basil oil composition is Camphora, limonene and/or β-selinene for example; And orange oil component for example australene, sabinene, myrcene, limonene, linalool, citronellal, neral and/or geranial.The EO that the application uses or IC can be obtained also by its natural source can chemosynthesis and obtain.

In the application's preferred non-limiting example, one or more EO in the set of the freely following material composition of EO choosing: Oleum Cinnamomi (CO) (skin or leaf), lemongrass oil (LGO) and basil oil (BO), above-mentioned substance does not almost have fragrance or without Oleum sesami, for example granada seed oil (PSO).

Flos Inulae contains a large amount of flavonoid, and this vegetalitas antioxidant protection human body cell is avoided the destruction of free radical.It has antiinflammatory, antiviral and antibacterial effect.Zooscopy shows, the blood flow that Flos Inulae may flow to injured area by increases is helped health and produced collagen protein and promote wound healing with this, therefore for skin and connective tissue are healed.

4.3 plant extract

Plant extract as herein described comprises plant, medical herbs and fruit extract, and it is not above-mentioned " quintessence oil ".The plant extract that the present invention uses includes but not limited to Wasabia japonic (Euterma Wasabi), Flos Lonicerae, cedar wood, aspen bark, bark of willow, Khalid Boulami (Herba Bacopae monnieri) extract, mandarin orange extract, Camellia sinensis (green tea), Fructus Vitis viniferae, Punica granatum L., Echinacea purpurea Moench, Herba Centellae, Ramulus Sambuci Williamsii, Irish moss, Radix Malvae sylvestris, soap bark, Y. flaccida Haw., Salvia Sclare L., Adeps Bovis seu Bubali, Herba thymi vulgaris, curcumin compound, resveratrol (derives from Fructus Vitis viniferae, the polyphenolic substance of berry etc.), Vetiveria zizanoides and their mixture.Can be any one part of plant for the plant that obtains plant extract, comprise leaf, sarcocarp, seed, or stem, fruit and fruit seed, can be also whole strain plant.Herb extracts can be, for example, be scattered in and/or be dissolved in the standard extract in aqueous medium.

Herb extracts example include but not limited to Flos Matricariae chamomillae, Herba Rosmarini Officinalis, Aloe, Herba Urticae Cannabinae, Herba Centellae, Semen Ginkgo, birch and Radix Hamamelidis Mollis.These extracts can transport in the carriers such as such as water, propylene glycol, water alcohol, glycerol or butanediol.Can use other extracts with nutritive effect, include but not limited to green tea, Ramulus et Folium Mussaendae Pubescentis, Pericarpium Vitis viniferae, Semen Vitis viniferae, resveratrol grapefruit, grapefruit seed, grapefruit peel, citrusfruit (except grapefruit extract), Pericarpium Citri tangerinae, Fructus Fragariae Ananssae, Semen Ginkgo, soybean isoflavone, soybean extract, fermented soybean protein, Radix vernoniae asperae, Radix Hyperici Monogyni (Herba Hyperici Monogyni), Echinacea purpurea Moench, Flos Matricariae chamomillae, Herba Rosmarini Officinalis, Aloe extract and juice, Herba Urticae Cannabinae, Cortex cocois radicis gel and Herba Centellae.Plant extract can obtain from for example Active Organics (Texas, USA Hillsborough town), New Age Botanicals (Texas, USA Garland town), Triarco Industries (New Jersey Wei Enzhen) and Aloecorp (Broomfield town, Colorado).

British plain spirits plant example includes but not limited to granada seed oil (PSO), edible plants extract Kefiprotect (KP) and tetrahydrocurcuminoid (THC).Have document to record, Rhizoma Curcumae Longae and curcumin have anti-inflammatory, non-oxidizability and wound healing effect.Following curcumin can be used for topical cream: tetrahydro curcumin, tetrahydro demethoxycurcumin, tetrahydro bisdemethoxycurcumin and their mixture.Other examples of plant extract include but not limited to Cortex cocois radicis, from Cortex cocois radicis, can obtain phospholipid (Arlasik phospholipid PTM), with horny layer in the natural acid mixture that exactly likes of fatty acid, there is natural pigment as the fatty acid mixt of carotene, carotenoid or plant sterol etc., these materials contribute to repair skin injury.Effectively plant extract instantiation comprises American Avocado Tree, and it contains sterol, sitosterol; Radix Dauci Sativae, it contains beta-carotene; Oleum sesami, it contains saturated and unsaturated fatty acids acid blend, and Brazil nut oil.Because the fatty acid kind containing is many, extract is being better than single fat acid aspect being combined with lipid layer structure as Brazil nut oil.Brazil nut oil (BNO) derives from South America Tropical rain forest trees Bertholletia excelsa and sets the fruit of bearing.

Plant extract also comprises flavonoid and terpenoid.Flavonoid of the present invention includes but not limited to rutin, Quercetin, Hesperidin and naringin.Terpenoid of the present invention includes but not limited to monoterpene, sesquiterpene and diterpene.

In the preferred non-limiting example of the present invention, one or more in the set of the freely following material composition of plant extract choosing: grapefruit seed extract (GSE), granada seed oil (PSO), citrusfruit extract or edible plants extract Kefiprotect (PK), the Cortex cocois radicis that contains phospholipid (Arlasik phospholipid PTM) and the mixture of tetrahydrocurcuminoid (THC).

4.4 sesquiterpene

Compositions disclosed herein comprises one or more sesquiterpenes, the set of the freely following material composition of choosing: farnesol, nerolidol, bisabolol, A Puli ketone, citral and their combination.

4.5 alkane glycol

In non-limiting example, according to the present invention, spendable difunctional alcohols is alkane glycol.Suitable alkane glycol includes but not limited to propylene glycol, butanediol, dodecanediol, decanediol, nonanediol, ethohexadiol, heptandiol, hexanediol and pentanediol.

In special non-limiting example, alkane glycol has the carbon skeleton of 3 to 25 carbon atoms, include but not limited to 1, 9-nonanediol, 1, 2-decanediol, 1, 10-decanediol, 1, 11-hendecane glycol, 1, 2-dodecanediol, 1, 2-dodecanediol, 1, 12-dodecanediol, cyclododecane glycol, 1, 13-tridecane glycol, 1, 2-tetradecane glycol, 1, 14-tetradecane glycol, 1, 15-pentadecane glycol, 1, 16-hexadecane glycol, 1, 17-heptadecane glycol, 1, 18-octacosanol, 1, 19-nonadecane glycol, 1, 20-eicosane glycol, 1, 21-heneicosandiol, 1, 22-docosane glycol, 1, 23-tricosane glycol, 1, 24-lignocerane glycol, 1, 25-pentacosane glycol.

In certain embodiments, alkane glycol is by obtaining in natural prodcuts.In certain embodiments, alkane glycol is obtained by chemosynthesis.

4.6 solvent

In different non-limiting examples, the present composition comprises one or more solvents, includes but not limited to the set of the freely following material composition of choosing: water, alcohols, plant source alcohols, glycols, glycerol, glycerol, Sensiva SC50, diglycerol, propylene glycol, dipropylene glycol and vegetable oil.

Preferred but nonrestrictive dissolving is fatty alcohol with non-alkane glycol example, it has 1 to 8 carbon atom, for example methanol, ethanol, normal propyl alcohol, isopropyl alcohol, 2-methyl-2-propanol, hexanol or their combination.Aromatic alcohol, for example but not, for restriction object, phenoxyethanol, benzyl alcohol, 1-phenoxy group-2-propanol and/or phenethanol, be not optionally combined with fatty alcohol yet.

Aromatic alcohol, for example but not, for restriction object, does not comprise phenoxyethanol, benzyl alcohol, 1-phenoxy group-2-propanol and/or phenethanol, for example, in the time that concentration is 0.5% to 5% (weight ratio), is also optionally combined with fatty alcohol.It is isopropyl myristate that the present composition selectively comprises another kind of solvent.Other fatty alcohol comprise ethanol, denatured alcohol (SDA40B and SDA3C) and isopropyl alcohol.

Comprise benzyl alcohol, galenical and 1, ammediol and derivant thereof are as 2-methyl isophthalic acid-nitro-1,3 propylene glycol (glycol) or 2-methylol-2-nitro-1, the compositions of the combination of ammediol (trihydroxylic alcohol) also contains cosolvent, as glycerol, Sensiva SC50, alcohol, glycol, butanediol and phenoxyethanol.

In preferred non-limiting example, solvent is benzyl alcohol, glycerol or their combination.

In certain embodiments, the working concentration scope of solvent is about 0.001% to 90% (weight ratio) or 1% to 85% (weight ratio) or 10% to 70% (weight ratio) or 30% to 65% (weight ratio).Can select in embodiment, concentration range is about 5% to 90% (weight ratio), is preferably about 30% to 90% (weight ratio), is more preferably 40% to 80% (weight ratio).In a preferred embodiment, solvent is natural product, for example, derive from the benzyl alcohol of Cortex Cinnamomi.

In the preferred non-limiting example of alternative of the present invention, solvent is benzyl alcohol or derivatives thereof, for example salicylic alcohol, nitrobenzyl alcohol or other derivants.Benzyl alcohol concentration range being about 0.5% to 10% (weight ratio), be preferably about 0.5% to 5% (weight ratio), there is antimicrobial efficacy while being more preferably 0.5% to 4% (weight ratio) together with certain plants organic acid especially fruit acid.The benzyl alcohol concentration range that alternative embodiment adopts is about 1.0% to 5.0% (weight ratio) or is about 1% to 3% (weight ratio).To below elaborate to carrying out further enhanced activity with the synthetic antimicrobial of other plant and benzyl alcohol with these fruit acid.

4.7 natural organic acids

The natural organic acids that can use for example fruit acid according to the present invention, includes but not limited to fruit acid, citric acid, glycolic, lactic acid, malic acid, tartaric acid, benzoic acid, salicylic acid and acetic acid.In some non-limiting example, fruit acid is Compound Water fruit acid (Multifruit BSC) (Qi chemical industry difficult to understand), for extracting the mixture from lactic acid, citric acid, tartaric acid and the malic acid of plant.In preferred non-limiting example, fruit acid is lactic acid.Fruit acid used in the present invention can be derived from natural resources or chemical industry is synthesized into.

Spendable other organic acid of compositions disclosed herein include but not limited to benzoic acid and the derivant including salt form thereof, for example benzyl benzoate, para-aminobenzoate, hydroxy benzoic acid, fluobenzoic acid and benzyl salicylate.

Can use fruit acid to assist the control of silver compound to discharge according to the present invention.The limiting examples of fruit acid includes but not limited to citric acid, glycolic, lactic acid, malic acid, tartaric acid and acetic acid.In some non-limiting example, fruit acid is Compound Water fruit acid (Multifont BSC) (Qi chemical industry difficult to understand), for extracting the mixture from lactic acid, citric acid, tartaric acid, glycolic and the malic acid of plant.The fruit acid that the present composition uses can be obtained or chemical industry is synthesized into by its natural resources.In the preferred non-limiting example of the present invention, fruit acid is lactic acid or citric acid.

In non-limiting example, the concentration range of fruit acid is about 0% to 70% (weight ratio) or is about 5% to 70% (weight ratio) or is about 5% to 20% (weight ratio) or is about 10% to 20% (weight ratio).Can select in non-limiting example in the present invention, concentration range is about 0% to 20% (weight ratio) or is about 0% to 40% (weight ratio) or is about 0.1% to 20% (weight ratio) or is about 0.2% to 4% (weight ratio) or is about 0.5% to 4% (weight ratio) or is about 2% to 4% (weight ratio).

In alternative embodiment, the natural organic acids concentration using in compositions is about 0.2% to 2% (weight ratio) or is about 0.2% to 1% (weight ratio).In other alternative embodiment, the natural organic acids concentration using in compositions is about 0.01% to 5% (weight ratio), or be about 0.01% to 4% (weight ratio), or be about 0.01% to 3% (weight ratio), or be about 0.01% to 2% (weight ratio), or be about 0.01% to 1% (weight ratio), or be about 0.02% to 5% (weight ratio), or be about 0.02% to 4% (weight ratio), or be about 0.02% to 3% (weight ratio), or be about 0.02% to 2% (weight ratio), or be about 0.02% to 1% (weight ratio), or be about 0.05% to 2.0% (weight ratio), or be about 0.1% to 2.0% (weight ratio).

4.8 personal care product

In non-limiting enforcement, personal care product compositions is provided, it comprises benzyl alcohol and one or more quintessence oils and/or one or more plant extracts, for example plant extract or fruit extract.Preferably, personal care product's pH value is about 3.0 to 6.0.

Use the personal care product's of the present composition limiting examples to comprise cake soap, liquid soap (for example handwashing liquid), disinfection hand cleanser (comprising wash type or retention type alcohol radical and water base hand sanitizer), skin sterilizing agent before operation, cleaning towel, disinfecting towel, bath gel, acne treatment product, antifungal hip pad cream, antifungal cold cream, shampoo, hair conditioner, cosmetics (include but not limited to liquid or opaque foundation emulsion, liquid or solid eyeliner, mascara, eye shadow cream, color powder, dry with or wet with muffin etc.), deodorizer, antibacterial ointment, health skin care liquid, hand cream, topical cream, aftershave lotion, toner/smoothing toner, collutory, toothpaste, suntan lotion and articles for babies, such as but not limited to cleaning towel, baby's shampoo, baby's soap and armlet frost.The present invention also can be applicable to Wound care products, such as but not limited to wound healing ointment, emulsifiable paste with put liquid, bandage, Sunice, binder, adhesive tape and wound closure band (steri-strips) on the skin, and medical supplies, such as medical care protective garment, cap, face shield and shoe cover, operation curtain etc.Other products include but not limited to oral-cavity article, for example mouthwass, toothpaste, dental floss coating, animal and pet care product, antiseptic composition and the surface disinfectant including solution, spray or wiping cloth.

Personal care composition as herein described also can comprise freely one or (preferably) Multiple components in the set of following material composition of choosing: emollient, stabilizing agent, thickening agent, heat preserving agent, antiinflammatory, antimicrobial, nertralizer, surfactant, water, organosilicon polymer, alcohol and water gel, also comprise the composition of knowing described in other this areas.The limiting examples of these compositions will below describe in detail.

In different non-limiting examples, personal care product can comprise emollient, for example PEG20 Semen Armeniacae Amarum glyceride, Probutyl DB-10, Glucam P-20, Glucam E-10, Glucam P-10, Glucam E-20, the two stearates of Glucam P-20, glycerol, propylene glycol, Sensiva SC50, cetyl acetate, Acetylated lanolin alcohols. (for example Acetulan), cetyl ether (for example PPG-10), myristicin (PPG-3), hydroxylation milk glyceride (for example Cremeral HMG), polyquaternary ammonium salt compound (for example U-care compound), diallyl dimethyl ammoniumchloride and acrylic acid copolymer (for example Merquat), dipropylene glycol methyl ether (for example Dowanol DPM, Dow Corning), glycol polypropylene ether (for example Ucon50-HB-600, Union Carbide) and silicon polymer.Other suitable emollient can comprise alkyl emollient, for example vaseline or mineral oil, fatty acid ester group emollient, methyl ester, isopropyl ester and the butyl ester of for example fatty acid, for example isopropyl palmitate, IPM, IPIS, isostearyl isostearate fat, Dermol DIPS, and propylene dipelargonate, different n-nonanoic acid-2-Octyl Nitrite, 2-Octyl Nitrite (2-ethylhexyl stearate), C ₁₂-C ₁₆fatty acid lactate (fatty alcohol lactate) is as lactic acid cetyl and LA, lanolin fatty acid isopropyl ester, salicylic acid-2-Octyl Nitrite, spermol myristinate, myristic acid oleyl alcohol ester, stearic acid oleyl alcohol ester, oleic acid oleic alcohol ester, lauric acid hexyl ester and lauric acid dissident ester.Other effective emollient comprise lanoline, olive oil, cocoa butter and Adeps Bovis seu Bubali resin.

In different non-limiting examples, personal care product can comprise a kind of stabilizing agent as antioxidant, such as but not limited to vitamin C (ascorbic acid) and/or vitamin E (tocopherol), and/or surfactant, such as but not limited to incromide or the surfactant based on siloxanes (Masil SF-19, BASF).

In different non-limiting examples, personal care product can comprise thickening agent and/or gellant, for example stearyl alcohol, cationic hydroxyethyl cellulose (Ucare, JR30), hydroxypropyl emthylcellulose, hydroxypropyl cellulose (Klucel), Kytamer PC Chitosan PCA (Kytamer), behenyl alcohol, zinc stearate, emulsifing wax, it includes but not limited to Incroquat and Polawax, for another kind of acrylate copolymer, resin as eTD ^tM2020, guar gum, Radix Acaciae senegalis, acrylate/stearic acid polyethers-20 methacrylate copolymer, agar, Algin, alginic acid, ammonium acrylate copolymer, ammonium alginate, ammonium chloride, ammonium sulfate, amylopectin, Attagel, bentonite, C ₉-C15 alcohol, calcium acetate, calcium alginate, chondrus ocellatus Holmes calcium, calcium chloride, secondary capryl alcohol, carbomer 910, carbomer 934, carbomer940, Acritamer 940, Carbopol 941, carboxymethyl hydroxyethyl cellulose, Carboxymethyl hydroxypropyl guar, chondrus ocellatus Holmes, glue fiber element, cellulose gum, palmityl alcohol, spermol, corn starch, hard gum, dextrin, bigeminy aniline Sorbitol, two (hydrogenated tallow acyl) ethylenediamine, two oleoyl ethylenediamines, ethylenedistearamide, gelatin, guar gum, guar gum hydroxypropyl trimethyl ammonia chloride, hectorite, hyaluronic acid, hydration Silicon stone, hydroxy butyl methyl cellulose, hydroxyethyl-cellulose, hydroxyethyl ethylcellulose, ethoxy stearmide-MIPA, different spermol, isooctadecanol, POLY-karaya, kelp, lauryl alcohol, locust bean gum, Magnesiumaluminumsilicate, magnesium silicate, magnesium trisilicate, methoxyl group PEG-22/ dodecyl glycol copolymer, methylcellulose, microcrystalline Cellulose, montorillonite clay, myristyl alcohol, oatmeal, oleyl alcohol, palm kernel alcohol, colloid, PEG (Polyethylene Glycol)-2M, PEG-5M, polyacrylic acid, polyvinyl alcohol, potassium alginate, polyacrylic acid aluminum potassium, chondrus ocellatus Holmes potassium, potassium chloride, potassium sulfate, potato starch, propylene glycol alginate, sodium acrylate/ethenol copolymer, carboxymethyl dextrin sodium, carrageenin sodium, cellulose sodium sulfate, sodium chloride, sodium polymethacrylate, sodium aluminosilicate, sodium sulfate, department draws chlorine by bentonite, oronain hectorite draws in department, stearyl alcohol, tallow alcohol, hydrochloric acid TEA salt, Tragacanth, tridecyl alcohol, trometamol Magnesiumaluminumsilicate, wheat flour, wheaten starch, xanthan gum, abietinol, propylene linoleic acid (acrylinoleic acid), behenic acid aluminum, aluminium octoate, dimerized linoleic acid aluminum, aluminum salt is as stearate, isostearic acid aluminum, Cera Flava, mountain Yu amide, butadiene/acrylonitrile copolymer, C29-70 acid, behenic acid calcium, calcium stearate, candelilla wax, babassu, ceresin, cholesterol, Cholesteryl hydroxystearate, cocoanut oil alcohol, Ke's handkerchief resin, diglycerol base stearate malate, dihydroabietyl alcohol, dimethyl lauryl amine oleate, dodecandioic acid/16/octadecanol/glycol copolymer, erucyl amide, ethyl cellulose, glycerol triethyl group hydroxy stearic acid ester, glycerol triethyl group ricinoleate, two behenic acid glycol esters, the sad glycol ester of diiodo-cyanophenyl, diglycol stearate, distearyl acid hexanediol ester, hydrogenation C6-C14 alkene polymers, castor oil hydrogenated, cotmar, hydrogenation leaf fat, hydrogenation pilchardine, hydrogenated palm kernel glyceride, hydrogenated palm kernel oil, hydrogenated palm oil, Parleam, oil with hydrogenated soybean, h-tallow amide, h-tallow glyceride, hydrogenated vegetable oil glyceride, hydrogenated vegetable oil, Japan wax, jojoba wax, lanolin alcohol, Adeps Bovis seu Bubali resin, lauramide, methyl dehydroabietate, hydrogenated rosins acid methyl ester, lambertianic methylate, methyl styrene/vinyl toluene copolymer, microwax, montanic acid wax, montan wax, myristyl EICOSANOL, myristyl octadecanol, octadecylene/maleic anhydride copolymer, octyl group dodecyl stearmide stearate, oleamide, oleostearin, ouricury wax, oxidic polyethylene, ceresine, paraffin, tetramethylolmethane hydrogenated rosins acid esters, tetramethylolmethane tetraiodo cyanophenyl caprylate, tetramethylolmethane rosinate, tetramethylolmethane four abietates, tetramethylolmethane four behenates, tetramethylolmethane four oleates, pentaerythritol tetrastearate, phthalic anhydride/glycerol/(+)-2,3-Epoxy-1-propanol decanoin copolymer, phthalic acid/trimellitic acid/glycol copolymer, polybutene, polytetramethylene alkene terephthalate, poly-dipentene, polyethylene, polyisobutylene, polyisoprene, polyvinyl butyral resin, polyvinyl alcohol laurate, propylene glycol dicaprylate, propylene glycol two cocos nucifera oil acid esters, propylene glycol two isodecyl acid esters, propylene glycol dilaurate, propylene glycol dipelargonate, propylene glycol distearate, the two hendecane acid esters of propylene glycol, PVP/ eicosylene copolymer, PVP/ hexadecene copolymer, rice bran wax, oronain bentonite draws in department, oronain hectorite draws in department, stearmide, the two stearates of stearmide DEA-, stearmide DIBA-stearate, stearmide MEA-stearate, stearone, stearyl mustard amide, stearyl alcohol stearate, stearyl alcohol stearoyl-oxy stearate, synthetic bees wax, synthetic wax, trihydroxy tristerin, three different ninth of the ten Heavenly Stems essence, three different stearins, three isooctadecanol trimerized linoleic acid esters, trilaurin, trimerized linoleic acid, trilinolein, trimyristin, triolein, glyceryl tripalmitate, Dodecanoic acid, zinc salt, zinc neodecanoate, resin acid zinc, and their mixture.The gellant using in product can be natural gellant, for example natural gum, starch, colloid, agar and gel.Under normal circumstances, gellant is taking polysaccharide or protein as basis.Example includes but not limited to guar gum, xanthan gum, alginic acid (E400), sodium alginate (E401), potassium alginate (E402), ammonium alginate (E403) alkane glycol, also can comprise heat preserving agent, for example glycerol, 1-2-propylene glycol, dipropylene glycol, Polyethylene Glycol, 1,3-butanediol or 1,2,6-hexanetriol.

In some non-limiting enforcement, can comprise one or more other antimicrobials, for example, the set of the following material composition of the optional freedom of these antimicrobials: silver salt, iodophor, iodine, benzoic acid, dihydrokainic acid, propanoic acid, sorbic acid, methyl hydroxybenzoate, ethyl hydroxybenzoate, propyl hydroxybenzoate, butyl hydroxybenzoate, cetrimonium bromide, alkyldimethylbenzylammonium chloride, dequalinium chloride, chlorhexidine, chlorocresol, chloroxylenol, benzyl alcohol, bronopol, Acetochlorone, phenoxyethanol, phenethanol, 2,4-DCBA, thimerosal, clindamycin, erythromycin, benzoyl peroxide, mupirocin, subtilin, polymyxin B, neomycin, triclosan, to chloro-m-xylene, FOSCARNET, miconazole, fluconazol, Yi Kang azoles, ketoconazole, silver sulfadiazin, Sensiva SC50 (octoxyglycerine), biguanide, such as but not limited to chlorhexidine free base, Palmic acid chlorhexidine, diaminobenzene phosphonic acids chlorhexidine, oneself is fixed for two Fructus Vitis viniferae hydrochlorates, CHA, two Chlorhexidine hydrochloride, dichloro chlorhexidine, dihydro iodine chlorhexidine, two perchloric acid chlorhexidines, dinitric acid chlorhexidine, sulphuric acid chlorhexidine, thiosulfuric acid chlorhexidine, bivalence phosphoric acid chlorhexidine (chlorhexidine di-acid phosphate), difluorophosphoric acid chlorhexidine, dioctyl phthalate chlorhexidine, dipropionic acid chlorhexidine, two iodo butanoic acid chlorhexidines, two positive valeric acid chlorhexidines, two caproic acid chlorhexidines, malonic acid chlorhexidine, succinic acid chlorhexidine, malic acid chlorhexidine, tartaric acid chlorhexidine, two monoethanol acid chlorhexidines, single diethyl alkyd chlorhexidine, lactic acid chlorhexidine, two-alpha-hydroxybutyric dehydrogenase chlorhexidine, chlorhexidine digluconate, two different thiosulfuric acid chlorhexidines, dibenzoic acid chlorhexidine, two cinnamic acid chlorhexidines, two mandelic acid chlorhexidines, two M-phthalic acid chlorhexidines, two-2 hydroxy naphthalene acid chlorhexidine, pamoic acid chlorhexidine and Polyhaxemethylenguanidine Hydrochloride (" PHMB ").

In different non-limiting examples, personal care product for example can comprise nertralizer, to neutralize the carboxyl occurring in one or more other compositions, the carboxyl in thickening agent.Suitable nertralizer comprises diisopropylamine and triethanolamine.

In different non-limiting examples, compositions can comprise surfactant.Described surfactant can be anionic surfactant, cationic surface active agent, amphoteric surfactant or nonionic surfactant.The example of nonionic surfactant comprises polyethoxylate (polyethoxylate), fatty alcohol (for example spermol polyethers-20 (a kind of cetyl ether of poly(ethylene oxide), there are average approximately 20 ethylene oxide units) and other can be from CI Americas, Inc. (Wilmington,State of Delaware, US) buys nonionic surfactant), fatty acid ester, sorbitan or the polyoxyethylene sorbitol acid anhydride of cocamido propyl betaine, alkyl phenol, Sorbitol.An instantiation of nonionic surfactant is 215 (Cognis), a kind of alkyl polyglucoside based on natural fatty alcohol C8-C10.Suitable anionic surfactant comprises ammonium lauryl sulfate and lauryl alcohol sulfosuccinic acid ether (lauryl ether sulfosuccinate).

In different non-limiting examples, personal care product can comprise water.

In different non-limiting examples, the compositions using in personal care product can comprise hydrogel, it comprises: for example a kind of compound, and as hydroxypropyl emthylcellulose, cationic hydroxyethyl cellulose (U-care polymer), ethyl cellulose, hydroxy propyl cellulose, hydroxy methocel, carboxymethyl cellulose, poly(ethylene oxide) (polyoxy resin) and chitosan 2-pyrrolidone-5-carboxylic acid ester (Kytomer PC).

In different non-limiting examples, personal care product can comprise the mixture of a kind of alcohol or multiple alcohol, for example ethanol, isopropyl alcohol, normal propyl alcohol and their mixture; Fatty alcohol, includes but not limited to spermol, myristyl alcohol, stearyl alcohol, capryl alcohol, decanol and lauryl alcohol, and their mixture; And hexanol.

In different non-limiting examples, the compositions using in personal care product can include organosilicon polymer, for example, dimethiconol liquid (Dow Corning1403 Azone liquid), Cyclomethicone and polydimethylsiloxanecopolymer copolymer (Dow Coming3225C silicone fluid) and silicone glycol (BASF1066DCG polyhydric alcohol) in one or more polydimethylsiloxanepolymer polymer (Dow Corning225 silicone fluid), dimethicone.

In different non-limiting examples, the compositions using in personal care product can comprise a kind of emollient, as alkyl chain reaches glycidyl ether and ethoxylate and the propoxylate of (containing) 18 carbon molecules, alkyl chain is glycerin ether and ethoxylate and the propoxylate of (containing) 18 carbon molecules nearly, alkyl chain is list or two polyglyceryl ethers and ethoxylate and the propoxylate of (containing) 18 carbon molecules nearly, ethyoxyl ether and propoxyl group ether, ethoxydiglycol ester, ethylhexyl propoxylate, propylene glycol ester ethoxylate and propoxylate, Arlamol (another name).

In different non-limiting examples, the compositions using in personal care product can comprise one or more additives, for example dyestuff; Aromatic; PH adjusting agent, comprise alkaline pH regulator, as ammonia, list-, two-and trialkylamine, list-, two-and three alkanolamines, alkali and alkaline earth metal ions hydroxide (for example, ammonia, sodium hydroxide, potassium hydroxide, Lithium hydrate, monoethanolamine, triethylamine, 2-aminopropane., diethanolamine and triethanolamine); Acidic ph modifier, for example mineral acid and polycarboxylic acid (for example, hydrochloric acid, nitric acid, phosphoric acid, sulphuric acid, citric acid, glycolic and lactic acid); Vitamin, for example VitAVitE and vitamin C; Polyamino acid and salt thereof, for example ethylenediaminetetraacetic acid (EDTA); Antiseptic, for example Germall plus or DMDM Hydantoin; And sunscreen, for example amino benzoic Acid, avobenzone (avobenzone), cinoxate, dioxybenzone (dioxybenzone), homosaligenin, menthol o-amino benzoyl ester, octocrilene, octyl methoxycinnamate, ethylhexyl salicylate, containing oxygen benzoate, padimate O, phenyl benzimidazole, sulfonic acid, sulisobenzone, titanium dioxide, triethanolamine Salicylate and zinc oxide.

In one group of non-limiting example, personal care composition has antimicrobial acivity and has again antiinflammatory (AM-AI) activity, and, for example, also can be used as skin cleaner or part ointment.

The present invention also provides the AMI hand disinfection liquid of quick acting.GSE, benzyl alcohol and 1,3-PD combination and antiinflammatory CRMN, edible plants extract while use together with granada seed oil (PSO), antimicrobial acivity strengthens.

The present invention has also proposed imagination to the vegetalitas AM-AI hand disinfection liquid of quick acting.

In concrete non-limiting example, the invention provides the preparation for the topical cream that comprises counter-stimulus, antiinflammatory, gellant and the galenical formula of minor cut or wound or wound surface.

Can general use alcohols as benzyl alcohol, fruit acid, can choice for use biguanide and alkyldimethylbenzylammonium chloride combination the antifungal activity of antifungal is obviously strengthened.

The present invention also provide comprise GSE, benzyl alcohol, the formula of THC and the phospholipid based on Cortex cocois radicis, for alcohol-based disinfectant handwashing liquid (AHS) compositions.

The present invention also provides not containing the vegetalitas hand disinfection liquid of alcohol, and it comprises approximately 0.5% to 2% (weight ratio) benzyl alcohol; Approximately 0.3% to 2% (weight ratio) silicone fluid; Approximately 0.1% to 0.5% (weight ratio) zinc oxide; Approximately 0.1% to 2% (weight ratio) fruit acid, for example lactic acid or citric acid; Approximately 0.05% to 1% (weight ratio) be selected from one or more galenicals in Aloe glue, GSE, Citrus reticulata Blanco extract, Wasabia japonic (Euterma Wasabi) extract, extract of willow bark, Populus davidiana extract and Flos Lonicerae extract; And approximately 0.1% to 0.5% (weight ratio) be selected from for example, one or more quintessence oils in Herba Origani oil, Punica granatum L. oil, oil of rosemary, lemongrass oil and Oleum Cinnamomi (, Cortex Cinnamomi leaf oil or Oleum Cinnamomi).These compositionss optionally comprise approximately 0.5% to 2% (weight ratio) farnesol, approximately 0.05% to 0.3% (weight ratio) thymol and/or approximately 0.2% to 1% (weight ratio) alkane glycol.

The limiting examples that does not contain the vegetalitas hand disinfection formula of liquid of alcohol will be described in detail below.

do not contain the vegetalitas hand disinfection liquid A of alcohol

Regulate pH value to 5.5-6.0

The concrete limiting examples that the present invention does not contain the vegetalitas hand disinfection formula of liquid of alcohol comprises following formula.

do not contain the vegetalitas hand disinfection liquid A of alcohol

Regulate pH value to 5.5-6.0

The non-limiting common instance that the present invention does not contain the vegetalitas hand disinfection formula of liquid of alcohol comprises following formula.

do not contain the vegetalitas hand disinfection liquid B of alcohol

Regulate pH value to 5.5-6.0.

do not contain the vegetalitas hand disinfection liquid B of alcohol

Regulate pH value to 5.5-6.0.

do not contain the vegetalitas hand disinfection liquid of alcohol

Regulate pH value to 5.5-6.0.

do not contain the vegetalitas hand disinfection liquid of alcohol

Regulate pH value to 5.5-6.0.

The present invention also provides the aqueous vegetalitas hand disinfection that contains benzyl alcohol and galenical liquid.It is below the non-limiting common instance of this formula.

aqueous vegetalitas hand disinfection liquid A

Regulate pH value to 5.5-6.0.

The concrete limiting examples of the aqueous vegetalitas hand disinfection liquid that the present invention contains benzyl alcohol and galenical comprises following formula.

aqueous vegetalitas hand disinfection liquid A

Regulate pH value to 5.5-6.0.

The non-limiting common instance of the aqueous vegetalitas hand disinfection liquid that the present invention contains benzyl alcohol and galenical comprises following formula.

aqueous vegetalitas hand disinfection liquid B

Regulate pH value to 5.5-6.0.

The non-limiting instantiation of the aqueous vegetalitas hand disinfection liquid that the present invention contains benzyl alcohol and galenical comprises following formula.

aqueous vegetalitas hand disinfection liquid B

Regulate pH value to 5.5-6.0.

aqueous vegetalitas hand disinfection liquid 1

Regulate pH value to 5.5-6.0.

aqueous vegetalitas hand disinfection liquid 1

Regulate pH value to 5.5-6.0.

aqueous vegetalitas hand disinfection liquid 2

Regulate pH value to 5.5-6.0.

aqueous vegetalitas hand disinfection liquid 2

Regulate pH value to 5.5-6.0.

aqueous vegetalitas hand disinfection liquid 3

Regulate pH value to 5.5-6.0.

aqueous vegetalitas hand disinfection liquid 3

Regulate pH value to 5.5-6.0.

The present invention also provides the aqueous vegetalitas hand disinfection that contains benzyl alcohol and galenical foam.It is below the non-limiting common instance of this formula.

aqueous vegetalitas hand disinfection foam A

Adjusting pH value is 4.0-4.5.

The non-limiting instantiation of the aqueous vegetalitas hand disinfection foam that the present invention contains benzyl alcohol and galenical comprises following formula.

aqueous vegetalitas hand disinfection foam A

Regulate pH value to 4.0-4.5.

The non-limiting common instance of the aqueous vegetalitas hand disinfection foam that the present invention contains benzyl alcohol and galenical comprises following formula.

aqueous vegetalitas hand disinfection foam B

Regulate pH value to 4.0-4.5

aqueous vegetalitas hand disinfection foam B

Regulate pH value to 4.0-4.5.

aqueous vegetalitas hand disinfection foam 1

Regulate pH value to 4.0-4.5 or 5.5-6.0.

aqueous vegetalitas hand disinfection foam 1

Regulate pH value to 4.0-4.5 or 5.5-6.0.

aqueous vegetalitas hand disinfection foam A1

Regulate pH value to 4.0-4.5.

aqueous vegetalitas hand disinfection foam A1

Regulate pH value to 4.0-4.5.

aqueous vegetalitas hand disinfection foam 2

Regulate pH value to 4.0-4.5.

aqueous vegetalitas hand disinfection foam 2

Regulate pH value to 4.0-4.5.

The present invention also provides the natural alcohol foam that contains benzyl alcohol and galenical hand sanitizer.It is below the limiting examples of this formula.

natural alcohol foam hand sanitizer

The non-limiting instantiation of the natural alcohol foam hand sanitizer that the present invention contains benzyl alcohol and galenical comprises following formula.

natural alcohol foam hand sanitizer

The non-limiting common instance of the natural alcohol foam hand sanitizer that the present invention contains benzyl alcohol and galenical comprises following formula.

natural alcohol foam hand sanitizer 1

The present invention also provides the natural alcohol operation that contains benzyl alcohol and galenical hand sanitizer.It is below the non-limiting common instance of this formula.

natural alcohol operation hand sanitizer

The natural alcohol operation that the present invention contains benzyl alcohol and galenical comprises following formula with the non-limiting instantiation of hand sanitizer.

natural alcohol operation hand sanitizer

The present invention also provides the vegetalitas that contains benzyl alcohol and galenical disinfectant soap.It is below the non-limiting common instance of this formula.

vegetalitas disinfectant soap A

The non-limiting instantiation of the vegetalitas disinfectant soap that the present invention contains benzyl alcohol and galenical comprises following formula.

vegetalitas disinfectant soap A

The non-limiting common instance of the vegetalitas disinfectant soap that the present invention contains benzyl alcohol and galenical comprises following formula.

vegetalitas disinfectant soap B

vegetalitas disinfectant soap

Provide in certain embodiments a kind of antifungal the anti-compositions of itching, it comprises approximately 0.5% (weight ratio) to 5% (weight ratio) benzyl alcohol and one or more compounds, the set of the freely following material composition of described compound choosing:

(a) approximately 0.04% (weight ratio) is to 0.5% (weight ratio) plant extract, and described plant extract selects the set of freely following material composition: Wasabia japonic (Euterma Wasabi) extract, Flos Lonicerae extract, cedar wood extract, aspen bark extract, extract of willow bark, Khalid Boulami (Brahmi) extract and their combination;

(b) approximately 0.04% (weight ratio) is to 1.05% (weight ratio) quintessence oil, and described quintessence oil selects the set of freely following material composition: lemongrass oil, Oleum Cinnamomi, Herba Origani oil, thymol, Rhizoma Alpiniae Officinarum oil, orange oil, Punica granatum L. oil, Flos Inulae oil, curried leaf oil or their combination; And

(c) approximately 0.2% (weight ratio) is to 2.0% (weight ratio) natural organic acids.

In some non-limiting example, provide following antifungal the anti-compositions of itching:

In the limiting examples of vegetalitas hand disinfection liquid that does not contain alcohol that contains benzyl alcohol and galenical in the application, prepare first respectively A phase solution and B phase solution, then mix, comprise following formula.

do not contain the vegetalitas hand disinfection liquid of alcohol

In the non-limiting instantiation of vegetalitas hand disinfection liquid that does not contain alcohol that contains benzyl alcohol and galenical in the application, prepare first respectively A phase solution and B phase solution, then mix, comprise following formula.

do not contain the vegetalitas hand disinfection liquid of alcohol

The application's the non-limiting common instance that does not contain the vegetalitas hand disinfection foam of alcohol comprises following formula.

do not contain the vegetalitas hand disinfection foam of alcohol

Regulate pH value to 4.0-4.5.

The non-limiting instantiation that the application does not contain the vegetalitas hand disinfection foam of alcohol comprises following formula.

do not contain the vegetalitas hand disinfection foam of alcohol

Regulate pH value to 4.0-4.5.

4.14 wound healing

The present composition can be used for promoting wound healing and/or prevents surface infection.In different non-limiting examples, the present composition can be used in for example topical cream and washing liquid, Wound care products, burn wound's emulsifiable paste, decubital ulcer emulsifiable paste (have antiinflammatory galenical and use silver sulfadiazin as antimicrobial) and treatment are used in ointment.The present composition also can be applicable to Wound care products, such as but not limited to wound healing ointment, bandage, Sunice, binder, adhesive tape and wound closure band, and be applied to medical supplies, for example medical care protective garment, cap, face shield and shoe cover, operation curtain etc.

In different non-limiting examples, compositions can comprise thickening agent and/or gellant, for example stearyl alcohol, cationic hydroxyethyl cellulose (Ucare, JR30), hydroxypropyl emthylcellulose, hydroxypropyl cellulose (Klucel), Kytamer PC Chitosan PCA (Kytamer), behenyl alcohol, zinc stearate, emulsifing wax, it includes but not limited to Incroquat and Polawax, for another kind of acrylate copolymer, resin as eTD ^tM2020, guar gum, Radix Acaciae senegalis, acrylate/stearic acid polyethers-20 methacrylate copolymer, agar, Algin, alginic acid, ammonium acrylate copolymer, ammonium alginate, ammonium chloride, ammonium sulfate, amylopectin, Attagel, bentonite, C ₉-C15 alcohol, calcium acetate, calcium alginate, chondrus ocellatus Holmes calcium, calcium chloride, secondary capryl alcohol, carbomer 910, carbomer 934, carbomer940, Acritamer 940, Carbopol 941, carboxymethyl hydroxyethyl cellulose, Carboxymethyl hydroxypropyl guar, chondrus ocellatus Holmes, glue fiber element, cellulose gum, palmityl alcohol, spermol, corn starch, hard gum, dextrin, bigeminy aniline Sorbitol, two (hydrogenated tallow acyl) ethylenediamine, two oleoyl ethylenediamines, ethylenedistearamide, gelatin, guar gum, guar gum hydroxypropyl trimethyl ammonia chloride, hectorite, hyaluronic acid, hydration Silicon stone, hydroxy butyl methyl cellulose, hydroxyethyl-cellulose, hydroxyethyl ethylcellulose, ethoxy stearmide-MIPA, different spermol, isooctadecanol, POLY-karaya, kelp, lauryl alcohol, locust bean gum, Magnesiumaluminumsilicate, magnesium silicate, magnesium trisilicate, methoxyl group PEG-22/ dodecyl glycol copolymer, methylcellulose, microcrystalline Cellulose, montorillonite clay, myristyl alcohol, oatmeal, oleyl alcohol, palm kernel alcohol, colloid, PEG (Polyethylene Glycol)-2M, PEG-5M, polyacrylic acid, polyvinyl alcohol, potassium alginate, polyacrylic acid aluminum potassium, chondrus ocellatus Holmes potassium, potassium chloride, potassium sulfate, potato starch, propylene glycol alginate, sodium acrylate/ethenol copolymer, carboxymethyl dextrin sodium, carrageenin sodium, cellulose sodium sulfate, sodium chloride, sodium polymethacrylate, sodium aluminosilicate, sodium sulfate, department draws chlorine by bentonite, oronain hectorite draws in department, stearyl alcohol, tallow alcohol, hydrochloric acid TEA salt, Tragacanth, tridecyl alcohol, trometamol Magnesiumaluminumsilicate, wheat flour, wheaten starch, xanthan gum, abietinol, propylene linoleic acid (acrylinoleic acid), behenic acid aluminum, aluminium octoate, dimerized linoleic acid aluminum, aluminum salt is as stearate, isostearic acid aluminum, Cera Flava, mountain Yu amide, butadiene/acrylonitrile copolymer, C29-70 acid, behenic acid calcium, calcium stearate, candelilla wax, babassu, ceresin, cholesterol, Cholesteryl hydroxystearate, cocoanut oil alcohol, Ke's handkerchief resin, diglycerol base stearate malate, dihydroabietyl alcohol, dimethyl lauryl amine oleate, dodecandioic acid/16/octadecanol/glycol copolymer, erucyl amide, ethyl cellulose, glycerol triethyl group hydroxy stearic acid ester, glycerol triethyl group ricinoleate, two behenic acid glycol esters, the sad glycol ester of diiodo-cyanophenyl, diglycol stearate, distearyl acid hexanediol ester, hydrogenation C6-C14 alkene polymers, castor oil hydrogenated, cotmar, hydrogenation leaf fat, hydrogenation pilchardine, hydrogenated palm kernel glyceride, hydrogenated palm kernel oil, hydrogenated palm oil, Parleam, oil with hydrogenated soybean, h-tallow amide, h-tallow glyceride, hydrogenated vegetable oil glyceride, hydrogenated vegetable oil, Japan wax, jojoba wax, lanolin alcohol, Adeps Bovis seu Bubali resin, lauramide, methyl dehydroabietate, hydrogenated rosins acid methyl ester, lambertianic methylate, methyl styrene/vinyl toluene copolymer, microwax, montanic acid wax, montan wax, myristyl EICOSANOL, myristyl octadecanol, octadecylene/maleic anhydride copolymer, octyl group dodecyl stearmide stearate, oleamide, oleostearin, ouricury wax, oxidic polyethylene, ceresine, paraffin, tetramethylolmethane hydrogenated rosins acid esters, tetramethylolmethane tetraiodo cyanophenyl caprylate, tetramethylolmethane rosinate, tetramethylolmethane four abietates, tetramethylolmethane four behenates, tetramethylolmethane four oleates, pentaerythritol tetrastearate, phthalic anhydride/glycerol/(+)-2,3-Epoxy-1-propanol decanoin copolymer, phthalic acid/trimellitic acid/glycol copolymer, polybutene, polytetramethylene alkene terephthalate, poly-dipentene, polyethylene, polyisobutylene, polyisoprene, polyvinyl butyral resin, polyvinyl alcohol laurate, propylene glycol dicaprylate, propylene glycol two cocos nucifera oil acid esters, propylene glycol two isodecyl acid esters, propylene glycol dilaurate, propylene glycol dipelargonate, propylene glycol distearate, the two hendecane acid esters of propylene glycol, PVP/ eicosylene copolymer, PVP/ hexadecene copolymer, rice bran wax, oronain bentonite draws in department, oronain hectorite draws in department, stearmide, the two stearates of stearmide DEA-, stearmide DIBA-stearate, stearmide MEA-stearate, stearone, stearyl mustard amide, stearyl alcohol stearate, stearyl alcohol stearoyl-oxy stearate, synthetic bees wax, synthetic wax, trihydroxy tristerin, three different ninth of the ten Heavenly Stems essence, three different stearins, three isooctadecanol trimerized linoleic acid esters, trilaurin, trimerized linoleic acid, trilinolein, trimyristin, triolein, glyceryl tripalmitate, Dodecanoic acid, zinc salt, zinc neodecanoate, resin acid zinc, and their mixture.The gellant using in product can be natural gellant, for example natural gum, starch, colloid, agar and gel.Under normal circumstances, gellant is taking polysaccharide or protein as basis.Example includes but not limited to guar gum, xanthan gum, alginic acid (E400), sodium alginate (E401), potassium alginate (E402), ammonium alginate (E403), calcium alginate (E404,-be derived from the polysaccharide of brown seaweed), agar (E406, be derived from the polysaccharide of Red seaweeds), carrageenin (E407, mostly being of obtaining from Red seaweeds is sugared), locust bean gum (E410, derive from the natural gum of Ceratonia siliqua seed), colloid (E440, the polysaccharide being obtained by Fructus Mali pumilae or citrus fruit) and gel (E441, made by animal collagen partial hydrolysis).

Different embodiment can comprise stabilizing agent.In a non-limiting example, by Dexol used as stabilizers, amount ranges is about 0.3% to 1% (weight ratio).

The application's different embodiment also can comprise surfactant.Described surfactant can be anionic surfactant, cationic surfactant, amphoteric surfactant or nonionic surfactant.The example of nonionic surfactant comprises polyethoxylate (polyethoxylate), fatty alcohol (for example spermol polyethers-20 (a kind of cetyl ether of poly(ethylene oxide), there are average approximately 20 ethylene oxide units) and other can be from CI Americas, Inc. (Wilmington,State of Delaware, US) buys nonionic surfactant), fatty acid ester, sorbitan or the polyoxyethylene sorbitol acid anhydride of cocamido propyl betaine, alkyl phenol, Sorbitol.Suitable anionic surfactant comprises ammonium lauryl sulfate and lauryl alcohol sulfosuccinic acid ether (lauryl ether sulfosuccinate).Preferred surfactant comprises lauroyl ethylenediamine triacetic acid sodium salt, Pluronic F87, Masil SF-19 (BASF) and incromide.

The deionized water of the preferred pH neutrality of water using in formula described herein.

In concrete non-limiting example, the invention provides wound healing topical cream, it comprises silver sulfadiazine, a kind of insoluble zinc salt, a kind of solvable zinc salt and Flos Inulae oil.In another non-limiting example, the invention provides wound healing topical cream, it comprises silver sulfadiazine, a kind of insoluble zinc salt, a kind of solvable zinc salt, Flos Inulae oil and antiinflammatory as curcumin compound.

The limiting examples of cream products also can comprise white petrolatum (2-20%) fatty alcohol (2-20%), emollient (1-10%), emulsifying agent (0.5-10%), wetting agent (2-15%), antiseptic (0.1-0.5%) and appropriate amount of deionized water or distilled water 100%.Fatty alcohol comprises stearyl alcohol, spermol, lauryl alcohol, myristyl alcohol and other known alcohol.Emollient comprises isopropyl myristate, lanoline, lanolin derivative, isopropyl palmitate, fat of Oromaius norvaehollandeae, Semen Lini oil and other known emollient.Emulsifying agent comprises single enuatrol and polyoxyethylene (40) stearate.Wetting agent comprises propylene glycol, sorbitol or glycerol or their mixture.Suitable waterborne-type preservation comprises Hydroxybenzenes (paraben), sorbic acid, benzoic acid, diazolidinyl urea and iodine propilolic alcohol butyl mephenesin Carbamate (Germal+).

The invention provides the vegetalitas wound healing gel formula that comprises benzyl alcohol and galenical.It is below the non-limiting common instance of this formula.

vegetalitas wound healing gel

Regulate pH value to 5.0-6.0.

The non-limiting instantiation of the application's the vegetalitas wound healing gel that contains benzyl alcohol and galenical comprises following formula.

vegetalitas wound healing gel

Regulate pH value to 5.0-6.0.

4.15 product for animals

In a part of non-limiting example, the invention provides the product for animals for nursing domestic animal, include but not limited to cat, Canis familiaris L., bird, rodent, horse, milch cow and cattle, sheep, goat etc.

Use the limiting examples of the care product for animals of the present composition to comprise house pet shampoo, pet cleaning pad, comprising health wiping cloth, ear wiping cloth and eyes wiping cloth, and tooth wiping cloth, toothpaste, ear cleaning solution, cage detergent, surface cleaner, the indoor cleaning agent of urinating and defecating, topical cream, ointment, for the teat dip of mastitis and be applied in the liquid (as " health moisturizing spraying ") on pet skin.

Also can comprise one or more (preferably) compositions according to the application's care composition for animals, the set of the freely following material composition of described composition choosing: emollient, stabilizing agent, thickening agent, heat preserving agent, antimicrobial, nertralizer, surfactant, water, silicone polymer, alcohol and hydrogel, antiinflammatory, Wound-healing agent, salicylic acid, also have other compositions known in the art.

The concrete limiting examples of other compositions that pet care product comprises comprises the composition that above-mentioned personal care product lists.

In some non-limiting example of the application, compositions can be the teat dip that is used for the treatment of mastitis.The counter-stimulus that teat dip uses can include but not limited to tool in the zinc salt of panthenol, there is the bisabolol of ginger-root extract (fragrant quick relaxing) or there is the fragrant quick of zinc salt and relax.The gel using in product can include but not limited to natural gel, for example natural gum, starch, colloid, agar and gel.Antimicrobial can include but not limited to for example citric acid of lemongrass oil, orange oil and fruit acid and lactic acid, phenoxyethanol (constituent of sage oil).

4.16 families/industrial products

In a part of non-limiting example, the invention provides the family/industrial products that comprise aforementioned formula.

Can use the non-limiting example of the family/industrial products of the present composition to comprise household cleaners, such as concentrated solution cleaning agent and spray cleaner, clean wiping cloth, wash dishes liquid, dish-washing machine washing agent, atomizing floor liquid, furniture polish, indoor paint, outdoor paint, dedusting spray, liquid detergent, fabric softening agent, carpet fabric cleaning agent, window and glass cleaner, detergent of closet agent, the cleaning agent of liquid/emulsifiable paste etc.In special embodiment, the present composition can be used in food cleaning products, for clean fruits and vegetables before edible." homebrew " is the product being used by individual consumer except personal care product." industrial products " refer to the product using in industry.

Can comprise one or more compositions according to family/industry group compound of the application, the set of the freely following material composition of described composition choosing: surfactant, short clean agent (the short clean agent of for example chelating, the short clean agent of precipitation, the short clean agent of ion exchange), solvent, thickening agent, abradant, acid, alkali (alkali metal), antimicrobial, soap, bleach, enzyme, antiseptic and foaming agent, and other compositions well known in the art.

In different non-limiting enforcement, compositions can comprise surfactant (such as but not limited to anion surfactant, as alkyl sulfate), alkyl diphenyl ether disulfonate (the DOWFAX series of for example being produced by Dow Chemical Company), alkylbenzenesulfonate, alcohol ethoxy sulfuric ester, for example secondary alcohol ethoxyl compound of nonionic surfactant (as the TERGITAOL series of being produced by Dow Chemical Company) or alkyl poly glucoside (as the TRITON series of being produced by Dow Chemical Company); Or for example imidazoline of amphoteric surfactant or betaine compound.

In different non-limiting examples, compositions can comprise solvent, such as but not limited to water, alcohol for example methanol, ethanol, isopropyl alcohol or butanols, Hydrocarbon for example aromatic hydrocarbons, propylene glycol methylene chloride acetone, petroleum distillate and/or glycol ether.

In different non-limiting examples, the compositions using in family/industrial products can comprise thickening agent, such as but not limited to Polyethylene Glycol, methoxy poly (ethylene glycol) and/or hydroxyethyl-cellulose.

In different non-limiting examples, the compositions using in family/industrial products can comprise abradant, such as but not limited to silicon dioxide, Anhydrite or calcite.

In different non-limiting examples, the compositions using in family/industrial products can comprise acid, such as but not limited to acetic acid, hydroxyacetic acid, phosphoric acid or hydrochloric acid.In different non-limiting examples, the compositions using in family/industry can comprise alkali (alkali metal), such as but not limited to ammonia or sodium bicarbonate.

In different non-limiting examples, the compositions using in family/industrial products can comprise antimicrobial, such as but not limited to the compound in previously described personal care composition, and Pinaster oil and sodium hypochlorite.

In different non-limiting examples, the compositions using in family/industrial products can comprise bleach, such as but not limited to sodium hypochlorite, hydrogen peroxide, SODIUM PERCARBONATE and Dexol.

In different non-limiting examples, the compositions using in family/industrial products can comprise enzyme, such as but not limited to protease or lipase.

In different non-limiting examples, the compositions using in family/industrial products can comprise antiseptic, such as but not limited to dibenzylatiooluene, glutaraldehyde and EDTA.

In different non-limiting examples, the compositions using in family/industrial products can comprise foaming agent, such as but not limited to ethanolamine or triethanolamine.

In concrete non-limiting example, the invention provides following table surface cleaning agent, the active component concentrated solution that comprises these formulas and concentrated stock solution, can be respectively dilute and obtain desired concn concentrated solution and concentrated stock solution.

In a part of non-limiting example, the invention provides the antiseptic and the surface disinfectant that contain aforementioned formula.

In non-limiting example, antiseptic of the present invention and surface disinfectant comprise following regular convention formula.

vegetable preservative A

Consumption is 0.20% to 1.0%.

In non-limiting example, antiseptic of the present invention and surface disinfectant comprise following concrete formula.

vegetable preservative A

Consumption is 0.20% to 1.0%.

vegetalitas surface disinfectant A

In non-limiting example, antiseptic of the present invention and surface disinfectant comprise following common aspect formula.

vegetalitas surface disinfectant B

crust disinfectant C

vegetalitas surface disinfectant LG-50

vegetalitas sterilization spray

4.17 armarium

In a part of non-limiting example, the invention provides the armarium that comprises aforementioned formula.

Position generation acute inflammatory reaction is inserted in being inserted in of armarium.This can cause forming biomembrane on armarium surface.The lip-deep biomembrane of armarium becomes the receptor of microorganism, produces microorganic adhesion.Prevent that the armarium inserting is inflamed and can prevents that microorganic adhesion is on this equipment around.By smearing and/or infiltrate antiinflammatory and antimicrobial keep equipment surrounding NIP and infect occurring, achieve the above object with this.

Antiinflammatory antimicrobial compositions comprises benzyl alcohol, 1, ammediol and THC combination (have or do not have other antimicrobials, for example chlorhexidine and silver salt), can smear or infiltrate in armarium, as catheter, wound dressing, soft-tissue patch etc.

4.18 insecticide

In a part of non-limiting example, the invention provides the insecticide that comprises aforementioned formula.In a non-limiting common instance, insecticide of the present invention comprises following formula.

vegetalitas vegetable insecticide

When use, above-mentioned composition can be with water dissolution to 1 for example to 10.

In non-limiting instantiation, insecticide of the present invention comprises following formula.

vegetalitas vegetable insecticide

5. example

Be elaborated in conjunction with following the application's concrete instance by reference herein.

Concrete instance refers to sometimes soap. soap is a kind of commercially available liquid soap, antibacterial hand soaps comprises activator, 0.15% triclosan, nonactive dose is water, sodium laureth sulfate, decyl glucoside, cocamido propyl betaine, glycerol, sodium chloride, PEG-18 glyceryl oleate/cocos nucifera oil acid esters, essence, coconut oleoyl amine MEA, DMDM Hydantoin, tetrasodium ethylenediamine tetraacetate and dyestuff.

Example 1

the antimicrobial efficacy of aqueous vegetalitas hand disinfection foam A: (15 seconds) and broad-spectrum antiseptic effect fast

Use FDA TFM method ^*(use a small amount of disinfection sanitizer and carry out microorganism culturing and slightly change, but share ratio is identical) tests quick kill bacteria effect.The various organic quick antibacterial activity (exposing for 15 seconds) that hand disinfection foam his-and-hers watches 1 of the present invention are listed is tested.The hand disinfection foam of testing comprises following formula.

aqueous vegetalitas hand disinfection foam A

Adjusting pH value is 4.0-4.5.

method

Briefly, hand disinfection foam (0.8 milliliter) is put into aseptic culture pipe, add 0.2 milliliter with 10 of 1:1 ABS dilution ⁹cfu/ml bacteria tested culture (or 10 ⁷cfu/ml Candida culture) and mix.After 15 seconds, with medicine neutralizer (DNF) termination antimicrobial acivity.Use DNF serial dilution, wait umber on pancreatin soy agar, again to cultivate to measure every increment microbe colony quantity originally.In contrast, use the phosphate buffered saline (PBS) (PBS) that contains identical bacterial cultures to replace test formulations.By measuring the log between matched group (phosphate buffered saline (PBS)) and test sample book ₁₀the poor of colony forming unit (cfu) (is log ₁₀reduce) calculate antibacterial activity.Carry out 3 experiments, test every group at every turn and comprise three samples.Carry out similarly test to compare to the soap that contains triclosan and PCMX with containing alcohol (62%) hand sanitizer.

Table 1: by FDA TFM method ^*the quick wide spectrum antimicrobial efficacy result of the aqueous vegetalitas hand disinfection foam obtaining and Purell

ND=does not examine

* the tentative final monograph of FDA TFM=; ATCC=US mode strain is collected center; MRSA=methicillin-resistant staphylococcus aureus; VREF=anti-vancocin enterococcus.

Matched group breeding growth scope is 5 × 10 ⁸to 1 × 10 ⁹cfu/ml.Result is the meansigma methods of every group of 12 samples.

example 2

the quick and durable antibiotic effect of aqueous vegetalitas hand disinfection foam A

Check the antimicrobial efficacy of aqueous vegetalitas hand sanitizer with Corii Sus domestica method of testing.Corii Sus domestica test simulation U.S. material and volunteer's method of testing the E-1174 of association (ASTM) (test organism: staphylococcus aureus).The hand disinfection foam of testing comprises following formula.

aqueous vegetalitas hand disinfection foam A

Adjusting pH value is 4.0-4.5.

method

Preparation 3cm ²corii Sus domestica, every Corii Sus domestica is fixed on culture dish.In order to determine base value, tap water for 2 Corii Sus domestica samples is rinsed 30 seconds, then with rub this two Corii Sus domesticas 30 seconds of 0.5 milliliter of non-antibacterial soap foam.Then these two Corii Sus domesticas are rinsed and within 30 seconds, remove spot with tap water.Every 15 microlitres 10 for Corii Sus domestica ⁷cfu/ml staphylococcus aureus culture fluid taint, phase mutual friction 30 seconds, dry 30 seconds.With the every Organic substance that Corii Sus domestica reclaims on Corii Sus domestica for 15 seconds of 10 milliliters of DNF flushings, collect washing liquid.The aliquot of serial dilution is evenly distributed on TSA flat board, cultivates 24-48 hour at 37 DEG C.In order to calculate effect of test sample book, will rinse with tap water for the identical Corii Sus domestica piece of determining base value, then rinse taint again with non-antibacterial soap.Dry after 30 seconds, 0.5 milliliter of test disinfectant is applied on Corii Sus domestica and cleans 30 seconds with soap bubble.After flushing, reclaim antibacterial with said method.Carrying out 9 taints and disinfectant uses again.Determine the colony counting after using for the 1st time and after using for the 10th time, calculate the log of the colony forming unit (cfu) between baseline sample and test sample book ₁₀difference (log ₁₀reduce).The antimicrobial acivity of hand disinfection foam is as shown in table 2.

Table 2: the quick and durable antibiotic effect (test organism: staphylococcus aureus (ATCC6538)) of repeatedly using rear hand disinfection foam A by Corii Sus domestica method.

Conclusion: according to US FDA-TFM standard, for Fast Anti microbial activity, log compared with counting with matched group after requiring to use for the 1st time ₁₀reduce 2.0log, for lasting antimicrobial acivity, require to use for the 10th time rear minimizing 3.0log.From different containing alcohol disinfectant Purell, the log that aqueous vegetalitas hand disinfection foam of the present invention has reached US FDA-TFM reduces standard.

example 3

the antimicrobial efficacy evaluation of surface disinfectant: externally kill fast (15 seconds) staphylococcus aureus

method

Surfactant (0.8ml) is put into aseptic culture pipe, add 0.2 milliliter with 10 of 1:1 Adult Bovine serum dilution ⁹cfu/ml test bacterium culture also mixes.After 15 seconds, with medicine nertralizer (DNF) termination antimicrobial acivity.Use DNF serial dilution, wait umber on pancreatin soy agar, again to cultivate to measure every increment microbe colony quantity originally.In contrast, use the phosphate buffered saline (PBS) (PBS) that contains identical bacterial cultures to replace test formulations.By measuring the log between matched group (phosphate buffered saline (PBS)) and test sample book ₁₀poor (be log ₁₀reduce) calculate antibacterial activity.The surface disinfectant of testing comprises following formula.

vegetalitas surface disinfectant LG-50

Table 3

* it contains long chain quaternary ammonium compound

Matched group count of bacteria: 8.5-9.9log ₁₀

The dilution of Proquart is carried out according to the instruction on Product labelling: Proquart0.17% quaternary ammonium compound (1 ounce and 2 ounces) is diluted to 1 gallon.

Conclusion: the antimicrobial efficacy of vegetalitas surface disinfectant is better than Proquart.

example 4

be exposed to the present composition after 10 minutes, disinfectant is for effect of drying bacteria on ceramic tile method

In this experiment using staphylococcus aureus, MRSA and escherichia coli as test Organic substance.First, water will be of a size of 5 × 15cm ²ceramic tile clean up, then clean with 70% ethanol, dry.With aseptic Glass rod by every part about 0.1 milliliter 1 × 10 ⁷cfu/ml microorganism is uniformly distributed on ceramic tile, dry 1 hour.0.3 milliliter of surface cleaner of the present invention is spread on ceramic tile to drying at room temperature 10 minutes.Rinsing ceramic tile surface with 9.7 milliliters of medicine neutralizers (DNF) enters in sterile petri dish to reclaim the microorganism remaining on ceramic tile.By recovering medium serial dilution, be laid on TSA flat board, hatch 18-24 hour at 37 DEG C, then determine colony counts.In contrast, carry out identical step, just with 0.3 milliliter of phosphate buffered saline (PBS) substitution list surface cleaning agent.Proquart is the disinfectant that contains quaternary ammonium compound (10.85% quaternary ammonium compound) that Clorox company produces, and it is tested as a comparison simultaneously.The surface disinfectant of testing comprises following formula.

vegetalitas surface disinfectant LG-50

The antimicrobial acivity of surface disinfectant is as shown in table 4.

Table 4

use LG-50 surface disinfectant 10 minutes effect to drying bacteria on ceramic tile

Matched group breeding growth scope is 5 × 10 ⁵-1 × 10 ⁶.

The LG50 that contains 0.12% quintessence oil (1 ounce) is diluted to 5 ounces.

Conclusion: the antimicrobial efficacy of this vegetalitas surface disinfectant is better than Proquart.

Quoted various patents and non-patent publications herein, its full content is incorporated to herein by reference.

Claims

1. an antimicrobial compositions, comprises:

(a) benzyl alcohol of approximately 0.5% weight ratio to 50% weight ratio;

(b) quintessence oil of approximately 0.01% weight ratio to 5% weight ratio;

(c) plant extract of approximately 0.5% weight ratio to 10% weight ratio, the set of the freely following material composition of described plant extract choosing: Wasabia japonic (Euterma Wasabi) extract, Flos Lonicerae extract, cedar wood extract, aspen bark extract, extract of willow bark, tobacco extract and their combination.

2. an antimicrobial compositions, comprises:

(a) benzyl alcohol of approximately 0.5% weight ratio to 50% weight ratio;

(b) quintessence oil of approximately 0.01% weight ratio to 5% weight ratio;

(c) plant extract of approximately 0.5% weight ratio to 10% weight ratio, the set of the freely following material composition of described plant extract choosing: Wasabia japonic (Euterma Wasabi) extract, grapefruit seed extract, Flos Lonicerae extract, the gloomy extract of Cedrus deoclar (Roxb.) G. Don, Punica granatum L. extract, Echinacea purpurea Moench extract, aspen bark extract, extract of willow bark and their combination.

3. an antimicrobial compositions, comprises:

(a) benzyl alcohol of approximately 0.5% weight ratio to 2.0% weight ratio;

(b) the specific cation complex of approximately 0.5% weight ratio to 4.0% weight ratio;

(c) benzoic acid of approximately 0.2% weight ratio to 0.5% weight ratio;

(d) one or more quintessence oils of approximately 0.05% weight ratio to 1% weight ratio, the set of the freely following material composition of described quintessence oil choosing: Herba Origani oil, thymol, oil of rosemary, Oleum Cinnamomi, Rhizoma Alpiniae Officinarum oil, Punica granatum L. oil and lemongrass oil; And

(e) one or more plant extracts of 0.2% weight ratio to 2.0% weight ratio, the set of the freely following material composition of described plant extract choosing: Wasabia japonic (Euterma Wasabi) extract, grapefruit extract, Citrus reticulata Blanco extract, Flos Lonicerae extract, Khalid Boulami extract, resveratrol Aloe gel and Folium Aloe juice.

4. compositions according to claim 3, also comprises the zinc oxide of 0.1% weight ratio to 0.5% weight ratio.

5. compositions according to claim 3, also comprises the sodium benzoate of 0.2% weight ratio to 0.5% weight ratio.

6. compositions according to claim 3, also comprises the pentanediol of approximately 0.1% weight ratio to 1.0% weight ratio.

7. an antimicrobial compositions, comprises:

(a) benzyl alcohol of approximately 0.1% weight ratio to 2.0% weight ratio;

(b) benzoic acid of approximately 0.1% weight ratio to 2.0% weight ratio;

(c) phenoxyethanol of approximately 0.5% weight ratio to 1.0% weight ratio;

(d) sesquiterpene of approximately 0.3% weight ratio to 1.3% weight ratio, its form is single sesquiterpene or sesquiterpenoids mixture;

(e) one or more quintessence oils of approximately 0.05% weight ratio to 2.5% weight ratio, the set of the freely following material composition of described quintessence oil choosing: Herba Origani oil, thymol, oil of rosemary, Oleum Cinnamomi, Rhizoma Alpiniae Officinarum oil, Punica granatum L. oil and lemongrass oil; And

(f) one or more galenicals of approximately 0.2% weight ratio to 2.0% weight ratio, the set of the freely following material composition of described galenical choosing: Wasabia japonic (Euterma Wasabi) extract, grapefruit extract, Citrus reticulata Blanco extract, Flos Lonicerae extract, Aloe gel and Folium Aloe juice.

8. compositions according to claim 7, also comprises approximately 0.5% weight ratio to 2.0% weight ratio cationic surfactant.

9. an antimicrobial compositions, comprises:

(a) benzyl alcohol of approximately 0.1% weight ratio to 2.0% weight ratio;

(b) benzoic acid of approximately 0.02% weight ratio to 2.0% weight ratio;

(c) phenylethanol of approximately 0.1% weight ratio to 1.0% weight ratio;

(d) sesquiterpene of approximately 0.02% weight ratio to 1% weight ratio, its form is single sesquiterpene or sesquiterpenoids mixture;

(f) one or more galenicals of approximately 0.05% weight ratio to 2.0% weight ratio, the set of the freely following material composition of described galenical choosing: Wasabia japonic (Euterma Wasabi) extract, grapefruit extract, Citrus reticulata Blanco extract, Flos Lonicerae extract, Aloe gel and Folium Aloe juice.

10. a Wound healing compositions, comprises:

(a) benzyl alcohol of approximately 0.1% weight ratio to 0.5% weight ratio;

(b) zinc oxide of approximately 0.2% weight ratio to 1.0% weight ratio;

(c) curcumin of approximately 0.05% weight ratio to 0.7% weight ratio; And

(d) in following material at least two kinds: Punica granatum L. oil, oil of rosemary, lemongrass oil, Oleum Cinnamomi, thymol and Phamnus cathartica L. oil, every kind of content of material approximately 0.1% weight ratio to 1.0% weight ratio.

11. 1 kinds of Cleasing compositions, the Pinaster oil of the lemongrass oil that comprises approximately 1% weight ratio to 5% weight ratio, approximately 0.1% weight ratio to 1% weight ratio and the citric acid of approximately 5% weight ratio to 20% weight ratio.

12. 1 kinds of antifungal topical ointment, the benzyl alcohol that comprises approximately 0.5% weight ratio to 5% weight and one or more compounds, the set of the freely following material composition of described compound choosing:

(a) plant extract of approximately 0.04% weight ratio to 0.5% weight ratio, the set of the freely following material composition of described plant extract choosing: Wasabia japonic (Euterma Wasabi) extract, Flos Lonicerae extract, cedar wood extract, aspen bark extract, extract of willow bark, Khalid Boulami extract and their combination;

(b) quintessence oil of approximately 0.04% weight ratio to 1.05% weight ratio, the set of the freely following material composition of described quintessence oil choosing: lemongrass oil, Oleum Cinnamomi, Herba Origani oil, thymol, Rhizoma Alpiniae Officinarum oil, orange oil, Punica granatum L. oil, Flos Inulae oil and their combination; And

(c) natural organic acids of approximately 0.2% weight ratio to 2.0% weight ratio.

13. 1 kinds of food sanitizers, comprise:

(a) benzyl alcohol of approximately 0.5% weight ratio to 5.0% weight ratio;

(b) plant extract of approximately 0.2% weight ratio to 1.0% weight ratio, the set of the freely following material composition of described plant extract choosing: Wasabia japonic (Euterma Wasabi) extract, Flos Lonicerae extract, cedar wood extract, aspen bark extract, extract of willow bark, tobacco extract, Citrus reticulata Blanco extract and their combination;

(c) fruit acid of approximately 0.2% weight ratio to 2.0% weight ratio;

(d) surfactant of approximately 0.1% weight ratio to 5.0% weight ratio; And

(e) water

14. 1 kinds of surface disinfectants, comprise:

(a) benzyl alcohol of approximately 1.0% weight ratio to 30% weight ratio;

(b) Pinaster oil of approximately 0.1% weight ratio to 4.0% weight ratio and blend of essential oils, the set of the freely following material composition of described quintessence oil choosing: lemongrass oil, orange oil, Cortex Cinnamomi leaf oil, Oleum Cinnamomi and their combination;

(c) fruit acid of approximately 2% weight ratio to 10% weight ratio;

(d) surfactant of approximately 5% weight ratio to 25% weight ratio; And

(e) water.

15. surface disinfectants according to claim 14, also comprise the fatty alcohol of 3-50% weight ratio.

16. 1 kinds of disinfectant, comprise:

(a) quintessence oil of approximately 2.5% weight ratio to 10% weight ratio, the set of the freely following material composition of described quintessence oil choosing: lemongrass oil, orange oil, Oleum Cinnamomi and their combination;

(b) Pinaster oil of approximately 0.5% weight ratio to 5.0% weight ratio;

(c) surfactant of approximately 25% weight ratio to 50% weight ratio;

(d) fruit acid of approximately 10% weight ratio to 20% weight ratio;

(e) fatty alcohol of approximately 20% weight ratio to 40% weight ratio; And

(f) water.

17. 1 kinds of insecticides, comprise:

(a) benzyl alcohol of approximately 5.0% weight ratio to 20% weight ratio;

(b) tobacco extract of approximately 0.01% weight ratio to 2.0% weight ratio;

(c) lemongrass oil of approximately 0.01% weight ratio to 2.0% weight ratio;

(d) cedarwood oil of approximately 0.5% weight ratio to 4.0% weight ratio; And

(e) the curried leaf oil of approximately 0.01% weight ratio to 2.0% weight ratio.