CN104027894A - Method for improving infiltration capacity of thrombolytic drug at thrombus part - Google Patents
Method for improving infiltration capacity of thrombolytic drug at thrombus part Download PDFInfo
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- CN104027894A CN104027894A CN201410268887.2A CN201410268887A CN104027894A CN 104027894 A CN104027894 A CN 104027894A CN 201410268887 A CN201410268887 A CN 201410268887A CN 104027894 A CN104027894 A CN 104027894A
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- thrombolytic drug
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- thrombus
- human body
- thrombosis
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Abstract
The invention discloses a method for improving infiltration capacity of thrombolytic drug at a thrombus part. The method for improving the infiltration capacity of the thrombolytic drug at the thrombus part includes that carrying out ultrasonic treatment on the thrombolytic drug before injecting the thrombolytic drug to a human body blood vessels, wherein the power density of the ultrasonic treatment is more than 0.1 W/cm2, the frequency range is 20 kHz to 10 MHzMHz, and the temperature of the thrombolytic drug is kept at 20 to 38 degrees centigrade in the ultrasonic treatment; after injecting the thrombolytic drug, exerting low-dosage ultrasonic with power density of 0.1 to 0.5 W/cm2 to the part of the human body which is easy to exert the ultrasonic, wherein the ultrasonic does not generate a cavitation effect in the human body. Compared with a thrombolytic drug treatment method which does not perform the ultrasonic treatment, the method for improving the infiltration capacity of the thrombolytic drug at the thrombus part does not need to use ultrasonic to irradiate the thrombus part, the ultrasonic thrombus decomposition treatment method is greatly simplified, and the number of the needed devices is reduced; ultrasonic cavitation treatment is not carried out on the thrombus part, and accordingly the retinal detachment risk due to the ultrasonic cavitation effect is reduced. The thrombolytic drug processed by the ultrasonic method is capable of improving the infiltration diffusion ability of the thrombolytic drug in a thrombus fibrin network structure.
Description
Technical field
The present invention relates to biomedical ultrasonics, relate in particular to a kind of thrombolytic drug that improves in the method for thrombosis position penetrating power.
Background technology
Apoplexy refers to the syndrome similar to wind disease of diseases caused by internal damage more, how because QI and blood is contrary disorderly, the resistance of brain BI-syndrome involved the blood vessels or blood oozing from the body openings or subcuta neous tissue be due to the brain.With unexpected confused servant, hemiplegia, numb limbs and tense tendons, stiffness of the tongue in silence, crooked mouth and tongue, the brain god disease that hemianesthesia etc. are main manifestations.In existing ultrasonic technique or by means of acoustic cavitation, remove thrombosis fibrin, or utilize microbubble expand the micro gap in thrombosis fibrin and then impel disintegrating of thrombosis.Because clinical experiment shows: focus supersonic is irradiated to thrombosis happening part, utilizes microbubble and/or the thrombolytic drug be injected into blood vessel, can accelerate the decomposition of thrombosis, obviously improve the rehabilitation probability of stroke patient simultaneously.
But existing ultrasonic thrombosis decomposition technique is generally to shine directly into thrombosis position, easily because cavitation effect causes hemorrhage complication.
Summary of the invention
The present invention is directed to the deficiencies in the prior art, provide a kind of thrombolytic drug that improves in the method for thrombosis position penetrating power, can improve thrombolytic drug infiltration diffusing capacity in thrombosis fibrin web frame.
The present invention is by the following technical solutions:
Improve thrombolytic drug in the method for thrombosis position penetrating power, at injection thrombolytic drug, enter before human vas, thrombolytic drug is carried out to supersound process.
The present invention carries out thrombolytic drug after supersound process, is injected in the blood vessel of stroke patient, can improve the diffusivity of thrombolytic drug in thrombosis fibrin net, and medicine arrives thrombosis position with blood circulation, infiltrates in thrombosis fibrin net.Its principle is as follows: in by the liquid of Ultrasonic Radiation, the static pressure that pressure is liquid adds ultrasonic acoustic pressure.Ultrasonic acoustic pressure is done cyclically-varying in time, in positive half cycle acoustic pressure, for just, in negative half period acoustic pressure, is negative.Thereby lower than static pressure at the pressure of negative half period blood, higher than static pressure at the pressure of positive half cycle liquid.The lower pressure of negative half period increases the average distance between fluid molecule, and intermolecular average gravitation diminishes.The elevated pressures of positive half cycle can make the average distance between fluid molecule reduce, but due to intermolecular repulsive force, intermolecular average gravitation changes little at positive half cycle.Thereby ultrasonic wave energy dies down the average gravitation between fluid molecule generally, and then the capillary percolation ability of raising liquid.
Physical Experiment shows: turn off ultrasonic after, also can in liquid, there is a period of time in this effect.Thereby, can first to thrombolytic drug, carry out in vitro non-thrombosis position in supersound process or body and carry out non-cavitation sonication, recycling blood circulation is transported to thrombosis position by the thrombolytic drug that was subject to sonication, minimizing due to intermolecular attraction, be subject to the thrombolytic drug of supersound process than not more can infiltrate in thrombosis fibrin net by means of capillary effect by the thrombolytic drug of sonication, accelerated the decomposition of thrombosis.
Ultrasonic cavitation refers to when ultrasonic energy is enough high, the micro-bubble being present in liquid vibrates, grows and constantly assembles sound field energy under the effect of ultrasonic field, when energy reaches certain threshold value, the process that cavitation bubble sharply collapses, and non-cavitating supersound process refers to the supersound process that this ultrasonic cavitation effect does not occur.
As preferably, while thrombolytic drug being carried out to supersound process outside human body, the power density of supersound process is greater than 0.1W/cm
2, frequency is 20kHz～10MHz.
As preferably, during supersound process, make the temperature of thrombolytic drug remain on 20～38 ° of C.If it is too large that medicine temperature and human body temperature differ, may have side effects to human body.
As preferably, after injection thrombolytic drug, human body is easily applied to ultrasonic position and (apply the happening part that ultrasonic position may not be thrombosis, but with respect to positions such as brains, more acceptant ultrasonic radiation, as extremity and/or buttocks) apply ultrasound wave, described ultrasound wave does not produce cavitation effect.
It is this that to apply ultrasonic mode be not in order to obtain therapeutic purposes, apply non-focusing low power ultrasound wave radiation easily applying ultrasonic non-thrombosis position, be in order to increase the quantity of raying medicine, thereby improve the infiltration diffusing capacity of thrombolytic drug in thrombosis fibrin web frame.
As preferably, when human body is easily applied ultrasound portion and carries out supersound process, ultrasonic power density is 0.1～0.5W/cm
2.
Take the stroke patient of thrombolytic drug, can also adopt ultrasonic foot washing basin foot bath and shank, use mattress and medicated cushion with ultrasonic transducer.
Beneficial effect:
Compare without the thrombolytic drug using method of supersound process with use, the present invention is irradiated thrombosis position without use is ultrasonic, greatly simplifies ultrasonic thrombosis and decomposes Therapeutic Method and reduce equipment needed thereby; Directly ultrasonic cavitation processing is not carried out in thrombosis position, reduce the probability because of sound cavitation effect generation hemorrhage complication, the thrombolytic drug after the present invention processes can improve the infiltration diffusing capacity of thrombolytic drug in thrombosis fibrin web frame.
Accompanying drawing explanation
Fig. 1: the present invention carries out the schematic diagram of supersound process to thrombolytic drug in human vas.
Number in the figure represents implication: 1, human body easily applies ultrasonic position; 2, human body surface; 3, blood vessel; 4, thrombosis fibrin; 5, infiltration direction; 6, direction of flow of blood.
The specific embodiment
Below by the specific embodiment, the present invention is described in further detail.
embodiment 1
Outside human body, utilize power density for 0.5W/cm
2, that frequency is 1MHz is ultrasonic, and thrombolytic drug is carried out to sonication 5min, makes the temperature of thrombolytic drug remain on 36 °～38 ° C when supersound process.By human body surface 2, be injected into subsequently the blood vessel 3 of stroke patient, the thrombosis fibrin 4 arriving in blood vessel 3 according to direction of flow of blood 6, the infiltration direction 5 of thrombolytic drug is to permeate to thrombosis fibrin net.Recording capillary percolation speed is 0.5mm/s.
embodiment 2
Outside human body, utilize power density for 0.5W/cm
2, that frequency is 1MHz is ultrasonic, thrombolytic drug is carried out to sonication 5min, when supersound process, make the temperature of thrombolytic drug remain on 36 °～38 ° C, be injected into subsequently the blood vessel 3 of stroke patient, then be 0.5W/cm from external blood vessel (being that human body easily applies ultrasonic position 1) irradiation power density to patient's arm
2, frequency is 1MHz non-cavitating is ultrasonic, time remaining 5min.Recording capillary percolation speed is 0.8mm/s.
embodiment 3
Outside human body, utilize power density for 1W/cm
2, that frequency is 1MHz is ultrasonic, and thrombolytic drug is carried out to non-cavitation sonication 5min, makes the temperature of thrombolytic drug remain on 38 ° of C when supersound process.Be injected into subsequently the blood vessel 3 of stroke patient, the thrombosis fibrin 4 arriving in blood vessel 3 according to direction of flow of blood 6, the infiltration direction 5 of thrombolytic drug is to permeate to thrombosis fibrin net.Recording capillary percolation speed is 1.2mm/s.
comparative example 1
Be with the difference of embodiment 1: the thrombolytic drug without supersound process is directly injected to human body, and recording capillary percolation speed is 0.125mm/s.
The test of embodiment 1 and drug osmotic speed in comparative example 1 shows: compare with the thrombolytic drug without supersound process, in vitro thrombolytic drug is carried out to supersound process and can make the seepage velocity of thrombolytic drug in thrombosis fibrin web frame improve 4 times.
comparative example 2
Be with the difference of embodiment 2: thrombolytic drug injects after human body, the blood vessel in patient's arm is not carried out to supersound process.Recording capillary percolation speed is 0.5mm/s.
The test of the drug osmotic speed in embodiment 2 and comparative example 2 shows: by power density, be 0.5W/cm
2, that frequency is 1MHz is ultrasonic, the thrombolytic drug that human body is easily applied to ultrasonic position carries out supersound process, thrombolytic drug can be brought up to 1.6 times at the seepage velocity in thrombosis fibrin web frame.
Claims (5)
1. improve thrombolytic drug in the method for thrombosis position penetrating power, it is characterized in that: at injection thrombolytic drug, enter before human vas, thrombolytic drug is carried out to supersound process.
2. raising thrombolytic drug according to claim 1, in the method for thrombosis position penetrating power, is characterized in that: the power density of supersound process is greater than 0.1W/cm
2, frequency is 20kHz～10MHz.
3. raising thrombolytic drug according to claim 1, in the method for thrombosis position penetrating power, is characterized in that: during supersound process, make the temperature of thrombolytic drug remain on 20～38 ° of C.
4. the method in thrombosis position penetrating power according to the raising thrombolytic drug described in claim 1 or 2 or 3, is characterized in that: after injection thrombolytic drug, human body is easily applied to ultrasonic position and apply the ultrasound wave that does not produce cavitation effect.
5. raising thrombolytic drug according to claim 4, in the method for thrombosis position penetrating power, is characterized in that: when human body is easily applied ultrasound portion and carries out supersound process, described ultrasonic power density is 0.1～0.5W/cm
2.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201410268887.2A CN104027894A (en) | 2014-06-17 | 2014-06-17 | Method for improving infiltration capacity of thrombolytic drug at thrombus part |
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| CN201410268887.2A CN104027894A (en) | 2014-06-17 | 2014-06-17 | Method for improving infiltration capacity of thrombolytic drug at thrombus part |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110801267A (en) * | 2019-10-31 | 2020-02-18 | 西安交通大学 | Ultrasonic fine efficient thrombolytic system assisted by low-intensity focusing vortex sound field |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020156400A1 (en) * | 2001-04-23 | 2002-10-24 | Eilaz Babaev | Ultrasonic method and device for wound treatment |
| US20120271167A1 (en) * | 2011-03-01 | 2012-10-25 | University Of Cincinnati | Methods of Enhancing Delivery of Drugs Using Ultrasonic Waves and Systems for Performing The Same |
| CN102836505A (en) * | 2011-06-15 | 2012-12-26 | 黄品同 | Focusing ultrasonic cavitation treatment instrument with ultrasonic focusing positioning function |
| CN103706047A (en) * | 2013-12-17 | 2014-04-09 | 南京航空航天大学 | Ultrasonic-based thrombolytic drug treatment method |
-
2014
- 2014-06-17 CN CN201410268887.2A patent/CN104027894A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020156400A1 (en) * | 2001-04-23 | 2002-10-24 | Eilaz Babaev | Ultrasonic method and device for wound treatment |
| US20120271167A1 (en) * | 2011-03-01 | 2012-10-25 | University Of Cincinnati | Methods of Enhancing Delivery of Drugs Using Ultrasonic Waves and Systems for Performing The Same |
| CN102836505A (en) * | 2011-06-15 | 2012-12-26 | 黄品同 | Focusing ultrasonic cavitation treatment instrument with ultrasonic focusing positioning function |
| CN103706047A (en) * | 2013-12-17 | 2014-04-09 | 南京航空航天大学 | Ultrasonic-based thrombolytic drug treatment method |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110801267A (en) * | 2019-10-31 | 2020-02-18 | 西安交通大学 | Ultrasonic fine efficient thrombolytic system assisted by low-intensity focusing vortex sound field |
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Application publication date: 20140910 |