CN205494701U - Device based on motion of ultrasonic wave controlling device microbubble - Google Patents
Device based on motion of ultrasonic wave controlling device microbubble Download PDFInfo
- Publication number
- CN205494701U CN205494701U CN201620129722.1U CN201620129722U CN205494701U CN 205494701 U CN205494701 U CN 205494701U CN 201620129722 U CN201620129722 U CN 201620129722U CN 205494701 U CN205494701 U CN 205494701U
- Authority
- CN
- China
- Prior art keywords
- microbubble
- motion
- micro
- utility
- supersonic generator
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Landscapes
- Surgical Instruments (AREA)
Abstract
The utility model discloses a device based on motion of ultrasonic wave controlling device microbubble. The utility model discloses a micro -fluidic device, microbubble output duct, micro - imaging system, device body and supersonic generator, the device body be box form, be provided with ultrasonic transducer on six faces of box, ultrasonic transducer be connected to supersonic generator, the box leaves there is the micropore for channeling into of microbubble, one end and this micropore of microbubble output duct are connected, and the other end is connected with micro -fluidic device, the box directly over the micro - imaging system who is used for surveing the microbubble motion still is equipped with. The utility model discloses except controlling the microbubble motion, also can control the various granules of receiving a little. The device integrates easily, and to human safety, easy operation is convenient, for the microbubble medical science and the more deep application in other fields provide the possibility.
Description
Technical field
This utility model belongs to field of fluid machinery, relates to a kind of device controlling microbubble motion based on ultrasound wave.
Background technology
Microbubble refers in particular to a diameter of several microns of bubbles arrived in hundreds of micrometer range.In recent years, the research about microbubble and application thereof has become focus, and microbubble is widely used in the fields such as medical science, oil, environment, mining, chemical industry, power, metallurgy, nuclear energy.
Ultrasound wave is a kind of frequency mechanical dilatational wave more than 20kHz, has been widely used in clinical diagnosis and treatment.Ultrasonic diagnostic technique is acknowledged as the most safe and efficient and low cost scanning detection method, and with surfactant or polymer capsule for the microbubble relied on, has become as maximally effective ultra sonic imaging contrast agent.Along with ultrasound medicine and the development of molecular biology, microbubble is increasingly used as a kind of carrier carrying medicine.The microbubble carrying medicine or gene enters in human body by intravenous injection or additive method, makes microbubble arrive target lesion tissue by the control moving microbubble, then by ultrasonic cavitation release medicine or gene, thus reaches efficient gene therapy effect.Recent research indicate that, microbubble technique has high application prospect at aspects such as targeted therapy, mediated gene treatment, thromboembolism and tumor targeted therapies.
Being precisely controlled microbubble motion can be that microbubble is applied to drug delivery, targeted therapy etc. medically and other field lays the foundation deeper into being widely applied.And it is the most little for the research of microbubble motor control.
Summary of the invention
This utility model is for the deficiencies in the prior art, it is provided that a kind of device controlling microbubble motion based on ultrasound wave.
This utility model includes micro fluidic device, microbubble output duct, micro imaging system, device body and supersonic generator.
Described device body is casing shape, is provided with ultrasonic transducer on six faces of casing, and described ultrasonic transducer is connected to supersonic generator；Having micropore at described casing, for the importing of microbubble, one end of microbubble output duct is connected with this micropore, and the other end is connected with micro fluidic device；The micro imaging system for observing microbubble motion it is also equipped with directly over described casing.
Furtherly, described casing uses glass box, is marked with deionized water at glass box.
This utility model compared with prior art, has the beneficial effect that
This device is except controlling microbubble motion, it is also possible to control various micro-nano particle.This being easily integrated of device, safe to the human body, simple and convenient, for microbubble medical science and other field deeper into application provide probability.
Accompanying drawing explanation
Fig. 1 is this apparatus structure schematic diagram；
Fig. 2 is device body schematic diagram；
In figure: 1, laboratory table, 2 micro fluidic devices generating microbubble, 3, microbubble output duct, 4 micro imaging systems, 5, device body, 6, dish sheet ultrasonic transducer, 7, connect supersonic generator and signal source and the power line of dish sheet ultrasonic transducer, 8, signal source and supersonic generator, 9, microbubble importing and liquid hand-hole.
Detailed description of the invention
This utility model device is made up of ultrasonic control parts, signal source and supersonic generator, micro imaging system, several parts such as micro fluidic device of generation microbubble, the most ultrasonic control parts are arranged in the transparent pane body glass box of a special processing, six faces of glass box all hollow out and inlay a piece of dish sheet ultrasonic transducer, with sealant sealing, ensureing the sealing of dish sheet ultrasonic transducer and glass jar junction, glass box overp0unch is in microbubble and liquid implantation glass case.
Glass box is positioned on object stage, fills water or other liquid in case, and the microbubble that micro fluidic device generates is incorporated in glass box from micro-fluidic chip by ultra-fine conduit.Six ultrasonic transducers connect supersonic generator respectively, then form three groups facing each other, connect three double-channel signal sources respectively, control the motion in three directions of microbubble.Observed by micro imaging system and determine that supersonic generator, with the presence of microbubble, after possessing the experiment condition carrying out next step ultrasonic control microbubble, is opened in target area.Ultrasonic frequency is relevant to controlled microbubble diameter, and for diameter at the microbubble of 1.5 μm to 150 μm, FREQUENCY CONTROL is between 20kHz to 2MHz.By the phase contrast of two channel signals in control signal source, the standing wave that can control one group of ultrasound wave moves, thus causes microbubble in standing wave to follow standing wave motion, it is achieved control the purpose of microbubble motion.The control of collaborative three groups of signal source phase places, it is possible to realize microbubble motion in three directions.
Embodiment:
As depicted in figs. 1 and 2, with ultrasound wave control microbubble motion in water as example, specific embodiments of the present utility model is:
Whole device is made up of several parts such as the power lines 7 of device body 5, signal source and supersonic generator 8, micro imaging system 4, the micro fluidic device 2 of generation microbubble, connection supersonic generator and signal source and dish sheet ultrasonic transducer.In wherein ultrasonic transducer is arranged on the transparent pane body glass box 5 of a special processing, six faces of glass box all hollow out and inlay a piece of dish sheet ultrasonic transducer 6, pass through sealant sealing, ensureing the sealing of ultrasonic transducer and glass box junction, top has microbubble and imports and liquid hand-hole 9；Signal source and supersonic generator 8, the ultrasonic frequency of generation is in the range of 20kHz to 2MHz.Example generates source of the gas with nitrogen or air as microbubble.
Six dish-shaped sheet ultrasonic transducers connect supersonic generator respectively, and form three groups facing each other, connect three double-channel signal sources, utilize the ultrasound wave standing wave formed with the frequency ultrasonic effect of contraction to microbubble a pair, control the unidirectional motion of microbubble.
Six faces are all inlayed the glass box cleaning of dish sheet ultrasonic transducer clean after, be positioned in laboratory table 1, and fill deionized water.First produce the microbubble of experiment required size with micro fluidic device (including micro-fluidic chip, gas tank, precise injection pump and some micro catheters and injector for medical purpose), the diameter of microbubble is between 1.5 μm to 150 μm.Connect the microbubble output channel of micro-fluidic chip with micro catheter, the microbubble of generation is imported in glass box target area by microbubble output duct 3, can observe whether target area exists microbubble by microscopy imaging system.
Determine after target area exists required microbubble, select suitable ultrasonic frequency according to microbubble size, then start ultrasonic generator.After stable etc. sound field, it is found that microbubble is constrained in a pair ultrasound wave standing wave with frequency ultrasonic formation.Adjust the phase contrast between two relative ultrasound wave by double-channel signal source, the motion of stationary field can be controlled, thus indirectly control the motion of microbubble.Utilize the synergism of three orthogonal ultrasound wave pair, it is possible to realize microbubble motor control in three directions.
To sum up, the utility model proposes a kind of brand-new device controlling microbubble motion, use ultrasound wave that microbubble can be driven move, and can motion to microbubble be precisely controlled targetedly, control process is simple to operation.
The above; it it is only preferred embodiment of the present utility model; not this utility model is imposed any restrictions; every any simple modification, change and equivalent structure change made above example according to this utility model technical spirit, all still falls within the protection domain of technical solutions of the utility model.
Claims (2)
1. the device controlling microbubble motion based on ultrasound wave, it is characterised in that: include micro fluidic device, microbubble output duct, micro imaging system, device body and supersonic generator；
Described device body is casing shape, is provided with ultrasonic transducer on six faces of casing, and described ultrasonic transducer is connected to supersonic generator；Having micropore at described casing, for the importing of microbubble, one end of microbubble output duct is connected with this micropore, and the other end is connected with micro fluidic device；The micro imaging system for observing microbubble motion it is also equipped with directly over described casing.
A kind of device controlling microbubble motion based on ultrasound wave the most according to claim 1, it is characterised in that: described casing uses glass box, is marked with deionized water at glass box.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201620129722.1U CN205494701U (en) | 2016-02-21 | 2016-02-21 | Device based on motion of ultrasonic wave controlling device microbubble |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201620129722.1U CN205494701U (en) | 2016-02-21 | 2016-02-21 | Device based on motion of ultrasonic wave controlling device microbubble |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN205494701U true CN205494701U (en) | 2016-08-24 |
Family
ID=56724087
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201620129722.1U Active CN205494701U (en) | 2016-02-21 | 2016-02-21 | Device based on motion of ultrasonic wave controlling device microbubble |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN205494701U (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105617542A (en) * | 2016-02-21 | 2016-06-01 | 中国计量学院 | Method for controlling movement of micro-bubble through supersonic waves |
| CN112296014A (en) * | 2020-11-24 | 2021-02-02 | 西北工业大学 | Sound vortex ultrasonic cleaning device |
-
2016
- 2016-02-21 CN CN201620129722.1U patent/CN205494701U/en active Active
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105617542A (en) * | 2016-02-21 | 2016-06-01 | 中国计量学院 | Method for controlling movement of micro-bubble through supersonic waves |
| CN105617542B (en) * | 2016-02-21 | 2020-01-17 | 中国计量学院 | Method for controlling movement of micro-bubbles by using ultrasonic waves |
| CN112296014A (en) * | 2020-11-24 | 2021-02-02 | 西北工业大学 | Sound vortex ultrasonic cleaning device |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN105617542A (en) | Method for controlling movement of micro-bubble through supersonic waves | |
| Wang et al. | Ultrasound imaging and tracking of micro/nanorobots: From individual to collectives | |
| Jeong et al. | Acoustic bubble-based drug manipulation: Carrying, releasing and penetrating for targeted drug delivery using an electromagnetically actuated microrobot | |
| WO2011146924A3 (en) | Ultrasonic device for harvesting adipose tissue | |
| AU2018285022B2 (en) | Cleaning, healing and regeneration of tissue and wounds | |
| CN103785311B (en) | Micro-nano bubble generator | |
| CN205494701U (en) | Device based on motion of ultrasonic wave controlling device microbubble | |
| US20180071505A1 (en) | Ultrasonic device for transversely manipulating drug delivery carriers and method using the same | |
| CA2584638A1 (en) | Medical device for generating transient bubbles | |
| Kwon et al. | Micro-object manipulation in a microfabricated channel using an electromagnetically driven microrobot with an acoustically oscillating bubble | |
| WO2007117964A2 (en) | Apparatus and method for vaccine development using ultrasound technology | |
| CN106148165B (en) | Micro-fluidic chip, injecting systems and its working method for cell injection | |
| CN106913922A (en) | Automatically Infusion support is followed | |
| Nitschke et al. | Collective guiding of acoustically propelled nano-and microparticles | |
| CN102988100A (en) | Low-resistance acupuncture method | |
| Wrede et al. | Controlled positioning of microbubbles and induced cavitation using a dual-frequency transducer and microfiber adhesion techniques | |
| CN202590026U (en) | Anti-blocking suction tube | |
| CN103372382B (en) | A kind of preparation facilities of therapeutic type micro air bubble ultrasonic contrast medium and method | |
| CA2577457A1 (en) | Microbubble medical devices | |
| CN202289080U (en) | Precise filter syringe | |
| CN201631868U (en) | Peripherally vein inserted central venous catheter | |
| CN203598334U (en) | Ultrasonic development catheter | |
| CN205537945U (en) | Ultrasonic sensor array based on liquid lens | |
| CN202288925U (en) | Novel ultrasonic low-temperature sterilization equipment | |
| Kim et al. | Ultrasonic Traveling Waves for Near-Wall Positioning of Single Microbubbles in a Flowing Channel |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant |