US20020156400A1 - Ultrasonic method and device for wound treatment - Google Patents

Ultrasonic method and device for wound treatment Download PDF

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Publication number
US20020156400A1
US20020156400A1 US09840416 US84041601A US2002156400A1 US 20020156400 A1 US20020156400 A1 US 20020156400A1 US 09840416 US09840416 US 09840416 US 84041601 A US84041601 A US 84041601A US 2002156400 A1 US2002156400 A1 US 2002156400A1
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ultrasound
liquid
method
tip
wound
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US6478754B1 (en )
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Eilaz Babaev
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Alliqua BioMedical Inc
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Celleration Inc
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    • BPERFORMING OPERATIONS; TRANSPORTING
    • B05SPRAYING OR ATOMISING IN GENERAL; APPLYING LIQUIDS OR OTHER FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05BSPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B17/00Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups
    • B05B17/04Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods
    • B05B17/06Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations
    • B05B17/0607Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations generated by electrical means, e.g. piezoelectric transducers
    • B05B17/0623Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations generated by electrical means, e.g. piezoelectric transducers coupled with a vibrating horn
    • B05B17/063Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations generated by electrical means, e.g. piezoelectric transducers coupled with a vibrating horn having an internal channel for supplying the liquid or other fluent material
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/005Sprayers or atomisers specially adapted for therapeutic purposes using ultrasonics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M35/00Devices for applying, e.g. spreading, media, e.g. remedies, on the human body ; Introducing media, e.g. remedies, into the body by diffusion through the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00Ultrasound therapy
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B05SPRAYING OR ATOMISING IN GENERAL; APPLYING LIQUIDS OR OTHER FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05BSPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B17/00Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups
    • B05B17/04Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods
    • B05B17/06Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations
    • B05B17/0607Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations generated by electrical means, e.g. piezoelectric transducers
    • B05B17/0623Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations generated by electrical means, e.g. piezoelectric transducers coupled with a vibrating horn
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/05General characteristics of the apparatus combined with other kinds of therapy
    • A61M2205/058General characteristics of the apparatus combined with other kinds of therapy with ultrasound therapy

Abstract

The method and device of the present invention for ultrasound wound treatment includes a transducer to produce ultrasonic waves. The ultrasonic transducer has tip with the distal end (radiation surface). A liquid is directed to the radiation surface throug central orifice or separate tube wherein an directed atomized particle spray of the liquid is created upon contact of the liquid with the radiation surface. The spray directed to the wound from at least 0.1 inches transmits ultrasound waves trough particles and has an irrigation, mechanical cleansing, liquid energizing and bactericide effect.

Description

    FIELD OF THE INVENTION
  • The present invention relates to a method of using ultrasonic waves in wound treatment. In particular, the present invention relates to a method of spraying a wound surface using ultrasonic waves for delivering drugs, killing bacteria, cleansing a surface, increasing blood flow and stimulating healthy tissue cells. [0001]
  • BACKGROUND OF THE INVENTION
  • Ultrasonic waves have been widely used in medical applications, including both diagnostics and therapy, as well as in many industrial applications. One diagnostic use of ultrasound waves includes using ultrasonic waves to detect underlying structures in an object or human tissue. In this method, an ultrasonic transducer is placed in contact with the tissue (or object) via a coupling medium, and high frequency (1-10 MHz) ultrasonic waves are directed into the tissue. Upon contact with underlying structures, the waves are reflected back to a receiver adjacent the transducer. By comparison of the signals of an ultrasonic wave as sent with the reflected ultrasonic wave as received, an image of the underlying structure can be produced. This technique is particularly useful for identifying boundaries between components of tissue and can be used to detect irregular masses, tumors, and the like. [0002]
  • Two therapeutic medical uses of ultrasonic waves include aerosol mist production and contact physiotherapy. Aerosol mist production makes use of a nebulizer or inhaler to produce an aerosol mist for creating a humid environment and delivering drug to the lung. [0003]
  • Ultrasonic nebulizers operate by passing ultrasonic waves of sufficient intensity through a liquid, the waves being directed at an air-liquid interface of the liquid from a point underneath or within the liquid. Liquid particles are ejected from the surface of the liquid into the surrounding air following the disintegration of capillary waves produced by the ultrasound. This technique can produce a very fine dense fog or mist. Aerosol mists produced by ultrasound are preferred because a smaller particle size of the aerosol can be obtained with the ultrasonic waves. One of the major shortcomings of inhalers and nebulizers is that there are no directed aerosol to the target without an air stream, which decreases the efficiency of ultrasound. [0004]
  • Contact physiotherapy applies ultrasonic waves directly to tissue in an attempt to produce a physical change in the tissue. In conventional ultrasound physiotherapy, an ultrasonic transducer contacts the tissue via a coupling medium. Ultrasonic waves produced by the transducer travel through the coupling medium and into the tissue. The coupling medium is typically a bath of liquid, a jelly applied to the surface to be treated, or a water-filled balloon. Conventional techniques provide ultrasonic waves having an intensity of from about 0.25 w/cm[0005] 2 to 3 w/cm2 at a frequency of from about 0.8 to 3 Megahertz. The treatment is applied to a skin surface for from about 1 to 30 minutes, two or three times a week. The coupling medium can provide a cooling effect which dissipates some of the heat energy produced by the ultrasonic transducer. More importantly, a coupling medium or direct contact between the tissue and the ultrasonic transducer is necessary to transmit the ultrasonic waves from the transducer to the skin surface because ambient air is a relatively poor medium for the propagation of ultrasonic waves.
  • Several beneficial effects have been reported from contact ultrasound physiotherapy. For example, the following effects have been associated with contact ultrasound physiotherapy: local improvement of the blood circulation, heating of the tissue, accelerated enzyme activity, muscle relaxation, pain reduction, and enhancement of natural healing processes. Despite these beneficial effects, current techniques of medical physiotherapy using ultrasonic waves are limited by the necessity of providing a direct contact interface between the ultrasonic transducer and the tissue to maintain an effective transmission of the ultrasonic waves from the transducer to the tissue. The necessity of direct contact with or without a coupling medium makes current methods undesirable. Some tissue conditions may be accessible to contact ultrasound devices but would be impractical for contact ultrasound treatment. For example, fresh or open wounds resulting from trauma, bums, surgical interventions are not suitable for direct contact ultrasound treatment because of the structural of the structural nature of the open wound and the painful condition associated with those wounds. Moreover, conventional contact ultrasound may have a destructive effect on these types of open wounds due to the close proximity of an oscillating tip of an ultrasonic transducer relative to the already damaged tissue surface. [0006]
  • OBJECT OF THE INVENTION
  • It is an object of the invention to provide a method and device for treating wounds. [0007]
  • It is also an object of this invention to provide a method and device for treating wounds using ultrasonic waves. [0008]
  • It is another object of the invention to provide a method and device for delivering drugs and irrigation to wounds. [0009]
  • It is a yet another object of the invention to provide a method and device for the mechanical cleansing and debridement of wounds. [0010]
  • It is a further object of the invention to provide a method and device for increasing blood flow in a wound area. [0011]
  • It is a yet further object of the invention to treat a wound by spraying the surface of the wound with an aerosol mist produced by ultrasonic waves. [0012]
  • These and other objects of the invention will become more apparent from the discussion below. [0013]
  • SUMMARY OF THE INVENTION
  • The present invention concerns a method and device for spraying a wound surface to deliver drugs, kill bacteria, or cleanse a surface by non-contact application of ultrasonic waves. The ultrasonic waves are applied to the wound without requiring direct or indirect (via a traditional coupling medium) contact between an ultrasonic wave transducer and the wound to be sprayed. [0014]
  • Ultrasonic sprayers (Sonic and Materials Inc., Misonix Inc., Sono-Tek Inc.; U.S. Pat. Nos. 4,153,201, 4,655,393, and 5,516,043) typically operate by passing liquid through the central orifice of the tip of an ultrasound instrument. Known applications are essentially industrial, such as a burner or device for coating of surfaces. No ultrasound wound or biological tissue treatment application with such a device has been indicated, with the exception of ultrasound liposuction. [0015]
  • According to the present invention a directed spray of liquid particles produced by contact of the liquid with a free end surface of an ultrasonic transducer is directed onto a wound. The ultrasonic waves cause the spray to project outwardly from the distal end surface, and the particles of the spray provide a medium for propagation of the ultrasonic waves emanating from the distal end surface. [0016]
  • In the method of the present invention, particle spray created by low frequency ultrasound waves and directed at the surface of a wound, can deliver drugs, kill bacteria on the wound, increase blood flow, and/or remove dirt and other contaminants from that surface (mechanical cleansing). This method of drug delivery is particularly advantageous on tissues for which local topical application of a drug is desirable yet contact with the tissue is to be avoided. Furthermore, the low frequency ultrasound waves used in the method energize the drug and cause penetration of the drug below the surface of the tissue. Finally, the bacteria killing method is effective when applied to the surface whether the liquid sprayed is a drug (an antiseptic or antibiotic), oil, saline, distilled water, or the like. [0017]
  • In a device acording to the invention, a spray is produced by first delivering liquid to the free distal end surface of an ultrasound tip through the axial (center) orifice or hose. After liquid is delivered to the free distal end surface, ultrasonic waves create the spray, which is directed to a particular targeted surface such a wound. Simultaneously ultrasonic waves are delivered to the wound surface through the spray. [0018]
  • The device must have a nozzle made from a rigid material such as steel (non-disposable) or plastic (disposable). The nozzle allows liquid to be delivered to a lateral surface of the transducer tip or directly to the distal side (radiation surface) of the ultrasound instrument to be sprayed.[0019]
  • BRIEF DESCRIPTION OF THE DRAWINGS
  • FIG. 1 is a perspective view of an ultrasonic wound treatment system for use according to the invention; [0020]
  • FIG. 2 is a partial cross-sectional view of the distal portion of an ultrasonic wound treatment device of the invention with a central orifice; [0021]
  • FIG. 3 is a partial cross-sectional view of the distal portion of an ultrasonic wound treatment device of the invention with no central orifice; [0022]
  • FIG. 4 is a partial cross-sectional view of the distal portion of an ultrasonic wound treatment device of the invention with focused ultrasound; [0023]
  • FIG. 5 is a partial cross-sectional view of the distal portion of an ultrasonic wound treatment device of the invention with a thread on a radial surface; [0024]
  • FIG. 6 is a partial cross-sectional view of the distal portion of an ultrasonic wound treatment device of the invention with a thread in a central orifice; [0025]
  • FIG. 7 is a partial cross-sectional view of the distal portion of a device for spraying where fluid is delivered to a lateral or radiation surface of the transducer tip by tube or sleeve and gas is delivered through the ultrasound tip's central orifice; [0026]
  • FIG. 8 is a partial cross-sectional view of the distal portion of a device for spraying where gas is delivered to a lateral or radiation surface of the transducer tip the through housing or bushing by perimeter of the tip and liquid is delivered through the ultrasound tip's central orifice; [0027]
  • FIG. 9 is a view illustrating use of a bushing for better effect of ultrasound standing waves to treat wounds; and [0028]
  • FIG. 10 is a partial cross-sectional view of a nozzle for ultrasound wound treatment using two tubes, one for carrying gas such a oxygen and another for carrying liquid such as a therapeutic agent.[0029]
  • DETAILED DESCRIPTION OF THE INVENTION
  • The present invention is a method and device, which uses ultrasonic wave energy to treat wounds. The device comprises a generator of electrical signals and a handpiece having an ultrasound transducer tip. The handpiece also comprises a tube for delivering drug to the radiation surface of the ultrasound tip. [0030]
  • The invention can perhaps be better appreciated from the drawings. In FIG. 1, a system [0031] 10 according to the invention comprises an ultrasound generator 12 in operative connection through cable 14 with an ultrasound handpiece 16. Handpiece 16 comprises an ultrasound nozzle 18 and a transducer 20 and is in fluid communication through connecting member 22 with liquid reservoir 24. Liquid dispensed from reservoir 24 contacts the distal end or radiation surface 26 of nozzle 18, resulting in a spray 30 that is directed toward the surface 32 of wound 34. In this fashion liquid is sprayed on the wound surface while ultrasonic waves are delivered to the wound.
  • FIG. 2 is a schematic representation of a cross-section of an ultrasonic nozzle tip [0032] 36 for wound treatment with a central lumen or orifice 38, as used in a device of the present invention. Liquid from a reservoir (not shown) is delivered in the direction of arrow 40 to the distal end 42 of ultrasound tip 36 through central orifice 38 to create ultrasound mist 44, which is directed to the surface 46 of a wound 48.
  • FIG. 3 is a schematic representation of a cross-section of an ultrasonic nozzle tip [0033] 50 for wound treatment with no central orifice, as used in a device of the present invention. Liquid from a reservoir (not shown) is delivered in the direction of arrow 52 to a solid distal end 54 of ultrasound tip 50 through a lumen 55 in tubing 56, to create ultrasound mist 58. Ultrasound mist 58 is directed to the surface 60 of a wound 62.
  • FIG. 4 is a schematic representation of a cross-section of an ultrasonic nozzle tip [0034] 66 with focused energy for wound treatment with no central orifice, as used according to the invention. Liquid 68 from a reservoir (not shown) is delivered in the direction of arrow 68 to the solid distal end 70 of ultrasound tip 66 through a lumen 71 in tubing 72 to create an ultrasound mist 74 that is directed to a focal point 76 on the surface 78 of a wound 80. Ultrasound tip distal end 70 is curved, e.g., elliptical, oval, etc.
  • FIG. 5 is a schematic representation of a cross-section of an ultrasonic nozzle tip [0035] 84 for wound treatment with grooves 86 on a radial surface 88. Liquid from a reservoir (not shown) is delivered in the direction of arrow 90 to radial surface 88 through a lumen 91 in tubing 92, to create an ultrasound mist 94. Ultrasound mist 94 is directed to the surface 96 of a wound 98. Grooves 86 can alternatively be threads or rings.
  • FIG. 6 is a schematic representation of a cross-section of an ultrasonic nozzle tip [0036] 102 for wound treatment with thread 104 in a central lumen or orifice 106. Liquid from a reservoir (not shown) is delivered in the direction of arrow 108 through central orifice 106 to the distal end 110 of ultrasound tip 102 to create an ultrasound mist 112. Ultrasound mist 112 is directed to the surface 114 of a wound 116.
  • FIG. 7 is a schematic representation of a cross-section of an ultrasonic nozzle tip [0037] 120 for wound treatment with a central lumen or orifice 122. Liquid from a reservoir (not shown) is delivered in the direction of arrow 124 through a lumen 128 in tubing 130 to the distal end 132 of ultrasound tip 120 to create an ultrasound mist 134. A gas such as oxygen is delivered in the direction of arrow 136 through central orifice 122. Ultrasound mist 134 is directed to the surface 138 of wound 140. Alternatively, liquid can be delivered in the direction of arrow 136 through central orifice 122 and gas can be delivered in the direction of arrow 124 through lumen 128.
  • FIG. 8 is a schematic representation of a cross-section of an ultrasonic nozzle tip [0038] 146 for wound treatment with a central lumen or orifice 148. Liquid from a reservoir (not shown) is delivered to the distal end 152 of ultrasound tip 146 through central orifice 148, to create an ultrasound mist 154. Ultrasound mist 154 also carries a gas such as oxygen, delivered in the direction of arrow 156 through annular channel 158 formed by bushing 160. Ultrasound mist 154 contacts the surface 164 of wound 166. Alternatively, gas liquid can be delivered in the direction of arrow 156 through annular channel 158 and gas can be delivered in the direction of arrow 150 through central orifice 148.
  • FIG. 9 is a schematic representation of a cross-section of an ultrasonic nozzle tip [0039] 168 for wound treatment with a central lumen or orifice 170 and an expanded bushing 176, which creates better conditions for standing waves. Liquid from a reservoir (not shown) is delivered in the direction of arrow 172. Substantially annular channel 174 is formed by expended bushing 176, and gas such as oxygen is delivered through annular channel 174 in the direction of arrow 178. An ultrasound mist 180 created at the distal end 182 of ultrasound tip 168 is directed at the surface 184 of wound 186. Alternatively, liquid can be delivered in the direction of arrow 178 through annular channel 174 and gas can be delivered in the direction of arrow 172 through central orifice 170.
  • FIG. 10 is a schematic representation of an ultrasonic nozzle tip [0040] 190 with no central orifice, where liquid is delivered from a reservoir (not shown) in the direction of arrow 192 through a lumen 194 in tubing 196 to the distal end 198 of tip 190. A gas such as oxygen is delivered from a gas source (not shown) in the direction of arrow 200 through a lumen 202 in tubing 204 to tip distal end 198. An ultrasound mist 206 created at tip distal end 198 is directed to the surface 208 of wound 216.
  • The cross-section of the ultrasonic nozzle tip can be circular, oval, elliptical, rectangular, multi-angular, trapezoidal, or a combination thereof. The distal end shape of the ultrasound nozzle tip may be the same or different, such as rectangular, elliptical, oval, spherical, conical, curved, stepped, with chamfer, etc. The most preferred shape is rectangular, due to radiation beams from the ultrasonic nozzle tip surface being fully directed to the target (wound). With the spherical, elliptical and oval shaped ends, radiation beams are focussed at a focal point, as shown, for example, in FIG. 4. With distal ends of other shapes, some of the radiation beams spread before reaching the target. [0041]
  • Radial side surface(FIG. 5) of distal end and central orifice (FIG. 6) of the ultrasond tip may have slot (groove)or thread for liquid to be directed to the radiation surface, which increases the liquid pressure. [0042]
  • Since local tissue oxygenation can stimulate tissue regeneration and prevent infection in wound treatment, the method of the present invention includes the mixing and delivery of oxygen and sprayed liquid (saline, water, therapeutic agent, etc., a shown, for example, in FIG. 7. In this case the liquid spray delivers oxygen or another gas to the wound. Gas or liquid can be delivered via tubing (FIG. 7) or housing (FIG. 8). [0043]
  • The step of producing the spray can further include operating the transducer to produce ultrasonic waves having a frequency of from about 18 to 10000 kHz. Although a frequency of 1 to 18 kHz can be used, this range should be avoided since this range of sound wave is uncomfortable to the patient and operator. The preferred range of frequency is from about 30 to 100 kilohertz, the most preferred frequency being about 40 kHz. [0044]
  • The distance of separation between the distal free end surface of the transducer and the surface to be sprayed is preferably from about 0.1 to 20 inches. [0045]
  • One of the benefits of the present invention is the use of the ultrasound standing waves for wound treatment. Ultrasound standing waves [0046] 210 occur when an ultrasound nozzle tip is activated through the air toward the wound surface as a result of incident and reflected waves from the wound surface, which creates ultrasonic radiation pressure. Standing waves 210, actually ultrasound radiation pressure, occur when the distance between the distal end of the transducer nozzle tip (as a radiant of ultrasound waves) and the reflected surface (wound surface) is: n.λ/2 (λ=wave length, n=integer). To reach this preferred distance and therefore this effect in wound treatment practice, the ultrasound transducer or tip must be moved back and forth toward the wound by the operator.
  • The standing waves are more effective in limited space or area as a tube. In this case use of a bushing [0047] 12 (FIG. 9) increases ultrasound radiation pressure. The bushing may or may not be disposable part on the distal end.
  • The liquid can further include any drug (antibiotic, anticeptic, etc.), saline, water (distilled or regular), or oil for application to the tissue. [0048]
  • In addition, the method of the invention can include directing the spray onto the surface for from about 1 second to about 30 minutes, dependant upon the condition and size of the wound. This can be done on a daily or semi daily basis, or two-three times per week or month. [0049]
  • The method of the present invention permits application of ultrasonic waves to the wound without establishing contact, directly or indirectly, between the ultrasonic transducer and the wound. For example, surfaces of the human body especially suited for treatment with the method of the present invention include infected and/or inflamed situations in open wounds, including trauma or gun shut wounds, and fire and chemical bums. [0050]
  • In addition, the method of the present invention is particularly suited to directing a spray into orifices or other body crevices that are difficult to access. [0051]
  • This method of wound treatment has a several advantages. First, this method topically applies medicines such as liquid antibiotics to the wound surface without the need to contact an infected, inflamed or painful tissue with an instrument. Second, a significant debridement, cleansing and bactericidal effect can occur, when spraying a wound surface using the method of the present invention. And third, aside from the bactericidal effect and advantages of non-contact treatment, use of the method of the present invention permits a significant reduction in volume used of liquid medicine used as compared with traditional methods for wound treatment. Similarly, this allows for precise dosage of the sprayed liquid to permit a user, such as a physician to administer the desired volume of liquid at a desired rate and duration. [0052]
  • The method of the present invention decreases healing times for inflammatory and purulent infected wounds, up to 1.5 to 2 times faster than traditional methods. This effect results from a bactericidal, blood flow increasing and mechanical cleansing effect of the atomized spray particles, which have ultrasound energy due to the ultrasonic waves. [0053]
  • The ultrasonic spray mechanically scrubs the surface of tissue to remove dirt, dead tissue, and purulent buildup on the tissue surface. [0054]
  • The mentioned healing effect also results of energized and highly activated antibiotics, drug penetration into the tissue surface up to 0.5 mm in depth under influence of ultrasound waves. Additionally, a combination of the low frequency ultrasonic waves and the sonicated medicines (highly activated by ultrasonic energy) destroy the surface bacteria to result in a higher disinfecting property of sonicated liquids as compared to ordinarily applied liquids. The spray of the present method also stimulates healthy cell growth to aid in granulization and epithelization of the healing tissue. Other applications of the method can be directed to non-medical uses such as cleansing, sterilizing and coating surfaces of objects and food. The method of the present invention offers an approach that may re-establish use of some traditional antibiotics and establish a method fighting bacteria without antibiotics when necessary. [0055]
  • The effect of the method of the present invention in highly activating antibiotics may allow some traditional antibiotics to overcome bacteria which have become resistant to that antibiotic. Moreover, independent of the sonication effect of the antibiotics, the low frequency ultrasonic waves applied in the method of the present invention physically destroy bacteria. The combination of the highly activated antibiotics and of the low frequency ultrasonic waves in the method of the present invention produce a strong bactericidal effect not found in mere topically application or orally ingested antibiotics. This combined effect has been shown to significantly increase the healing of purulent infected wounds. [0056]
  • The present method also provides a system of non-contact drug delivery without using a compression sprayer system. This simplifies the design of a non-contact drug delivery sprayer and reduces the weight of the sprayer. More importantly, not using compression to propel the atomized particles preserves the ultrasound energy carried by the spray particles. [0057]
  • The method of the present invention provides a method of compressionless non-contact drug delivery. [0058]
  • It is to be understood, however, that other expedients known to those skilled in the art or disclosed herein, may be employed without departing from the spirit of the invention or the scope of the appended claims. [0059]

Claims (22)

    What is claimed is:
  1. 1. A method for ultrasound wound treatment comprising the steps of:
    (a) producing an ultrasonic spray of liquid particles produced by the contact of liquid with an ultrasonic nozzle tip operating at a frequency of 16 kHz to 103 MHz, and
    (b) directing the ultrasonic spray onto a wound surface while maintaining the tip surface at a distance of at least about 0.1 inches from the wound surface.
  2. 2. The method of claim 1, wherein the liquid contacts a radiation surface of an ultrasound tip or instrument to produce a spray from liquid flow or drops.
  3. 3. The method of claim 1, wherein in step (a) the liquid is supplied to the ultrasound tip or instrument at a different position, which causes the liquid particles to be energized.
  4. 4. The method of claim 3, wherein in step (a) the liquid is supplied to the ultrasound tip or instrument via a central orifice.
  5. 5. The method of claim 3, wherein in step (a) the liquid is supplied to the ultrasound tip or instrument via a separate tube.
  6. 6. The method of claim 1, wherein ultrasound waves are directed and transported to the wound surface through liquid spray.
  7. 7. The method of claim 1, wherein ultrasound waves are directed to the wound surface and transport gas to the wound through liquid spray.
  8. 8. The method of claim 1, wherein ultrasound liquid spray directed to the wound surface has irrigation, mechanical debridement and/or cleansing effect.
  9. 9. The method of claim 1, wherein ultrasound liquid spray directed to the wound surface has a blood flow increasing effect.
  10. 10. The method of claim 1, wherein the liquid comprises at least one substance selected from the group consisting of antibiotics, antiseptics, saline, oil, water, and combinations of two or more thereof.
  11. 11. The method of claim 1, wherein the ultrasound frequency is modulated.
  12. 12. The method of claim 1, wherein the ultrasound frequency is pulsed.
  13. 13. A method for ultrasound wound treatment comprising the step of driving an ultrasonic tip or instrument with constant frequency to create liquid spray.
  14. 14. A method for ultrasound wound treatment comprising the step of driving an ultrasonic tip or instrument with sinusoidal ultrasound wave
  15. 15. The method of claim 14, wherein the ultrasound wave form is rectangular.
  16. 16. The method of claim 14, wherein the ultrasound wave form is trapezoidal.
  17. 17. The method of claim 14, wherein the ultrasound wave form is triangular.
  18. 18. A device for ultrasound wound treatment, which comprises:
    (a) an ultrasound transducer,
    (b) an ultrasound nozzle attached to said transducer, said nozzle having a tip with a radiant distal end, and
    (c) a liquid supply in fluid communication with said nozzle distal end, wherein a liquid spray is generated that can be directed to the surface of a wound.
  19. 19. The device of claim 18, wherein the ultrasound tip of the sprayer has different modification of distal end (radiation surface).
  20. 20. The device of claim 19, wherein the radial side surface of the distal end of ultrasound tip has one or more grooves.
  21. 21. The device of claim 19, wherein the radial side surface of the distal end of ultrasound tip has threads.
  22. 22. The device of claim 19, wherein the radial side surface of the distal end of the ultrasound tip has rings.
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Cited By (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020016557A1 (en) * 1997-02-14 2002-02-07 Duarte Luiz R. Ultrasonic treatment for wounds
WO2004110649A1 (en) * 2003-06-18 2004-12-23 Abb Patent Gmbh Standing ultrasonic wave spraying arrangement
US20050038377A1 (en) * 2000-08-24 2005-02-17 Redding Bruce K. Ultrasonically enhanced substance delivery system and device
US20050075599A1 (en) * 2001-08-24 2005-04-07 Redding Bruce K. Ultrasonically enhanced saline treatment for burn damaged skin
US20060015059A1 (en) * 2002-01-16 2006-01-19 Redding Bruce K Jr Substance delivery device
US20060089632A1 (en) * 2004-10-06 2006-04-27 Guided Therapy Systems, L.L.C. Method and system for treating acne and sebaceous glands
US20060184071A1 (en) * 1997-12-29 2006-08-17 Julia Therapeutics, Llc Treatment of skin with acoustic energy
WO2007084792A3 (en) * 2006-01-23 2007-12-13 Kci Licensing Inc System and method for treating a wound using ultrasonic debribement
US20080027328A1 (en) * 1997-12-29 2008-01-31 Julia Therapeutics, Llc Multi-focal treatment of skin with acoustic energy
WO2008024532A1 (en) * 2006-08-21 2008-02-28 Boston Scientific Scimed, Inc. Ultrasound catheter
WO2008036622A2 (en) * 2006-09-18 2008-03-27 Guided Therapy Systems, Llc Method and system for non-ablative acne treatment and prevention
US20080095920A1 (en) * 2005-08-04 2008-04-24 Eilaz Babaev Ultrasound medical device coating method
US20080119779A1 (en) * 2006-09-29 2008-05-22 Eilaz Babaev Method of Treating Lumens, Cavities, and Tissues of the Body with an Ultrasound Delivered Liquid.
US20080128362A1 (en) * 2006-12-04 2008-06-05 Bacoustics Llc Method of ultrasonically treating a continuous flow of fluid
US20080146970A1 (en) * 2005-12-06 2008-06-19 Julia Therapeutics, Llc Gel dispensers for treatment of skin with acoustic energy
US20080243047A1 (en) * 2007-03-27 2008-10-02 Babaev Eilaz P Ultrasound wound care device
US20090005710A1 (en) * 2004-10-01 2009-01-01 Duplogen, Inc. Ultrasonic Equipment for Treatment of Osteoarthritis
US20090099485A1 (en) * 2007-10-16 2009-04-16 Sarvazyan Armen P Ultrasound standing wave method and apparatus for tissue treatment
US20090200390A1 (en) * 2008-02-12 2009-08-13 Eilaz Babaev Ultrasound atomization system
US20090312693A1 (en) * 2008-06-13 2009-12-17 Vytronus, Inc. System and method for delivering energy to tissue
US20090312673A1 (en) * 2008-06-14 2009-12-17 Vytronus, Inc. System and method for delivering energy to tissue
US20100063423A1 (en) * 2006-12-19 2010-03-11 Cedars-Sinai Medical Center Ultrasonic bath to increase tissue perfusion
WO2010067239A3 (en) * 2008-12-11 2010-08-05 Koninklijke Philips Electronics, N.V. System and method for monitoring nebulization of a medicament
US7789841B2 (en) 1997-02-06 2010-09-07 Exogen, Inc. Method and apparatus for connective tissue treatment
US7819918B2 (en) * 2001-07-16 2010-10-26 Depuy Products, Inc. Implantable tissue repair device
US7842249B2 (en) 2006-03-29 2010-11-30 Bacoustics, Llc Apparatus for vaccine development using ultrasound technology
US7871440B2 (en) 2006-12-11 2011-01-18 Depuy Products, Inc. Unitary surgical device and method
US7950594B2 (en) 2008-02-11 2011-05-31 Bacoustics, Llc Mechanical and ultrasound atomization and mixing system
US8016208B2 (en) 2008-02-08 2011-09-13 Bacoustics, Llc Echoing ultrasound atomization and mixing system
US8166332B2 (en) 2005-04-25 2012-04-24 Ardent Sound, Inc. Treatment system for enhancing safety of computer peripheral for use with medical devices by isolating host AC power
US8235909B2 (en) 2004-05-12 2012-08-07 Guided Therapy Systems, L.L.C. Method and system for controlled scanning, imaging and/or therapy
US8235919B2 (en) 2001-01-12 2012-08-07 Celleration, Inc. Ultrasonic method and device for wound treatment
US8282554B2 (en) 2004-10-06 2012-10-09 Guided Therapy Systems, Llc Methods for treatment of sweat glands
US8409097B2 (en) 2000-12-28 2013-04-02 Ardent Sound, Inc Visual imaging system for ultrasonic probe
WO2013067041A1 (en) * 2011-11-01 2013-05-10 Indrani Deo Dispensing nozzle with an ultrasound activator
US8444562B2 (en) 2004-10-06 2013-05-21 Guided Therapy Systems, Llc System and method for treating muscle, tendon, ligament and cartilage tissue
US8460193B2 (en) 2004-10-06 2013-06-11 Guided Therapy Systems Llc System and method for ultra-high frequency ultrasound treatment
US8480585B2 (en) 1997-10-14 2013-07-09 Guided Therapy Systems, Llc Imaging, therapy and temperature monitoring ultrasonic system and method
US8491521B2 (en) * 2007-01-04 2013-07-23 Celleration, Inc. Removable multi-channel applicator nozzle
US8535228B2 (en) 2004-10-06 2013-09-17 Guided Therapy Systems, Llc Method and system for noninvasive face lifts and deep tissue tightening
US8636665B2 (en) 2004-10-06 2014-01-28 Guided Therapy Systems, Llc Method and system for ultrasound treatment of fat
US8663112B2 (en) 2004-10-06 2014-03-04 Guided Therapy Systems, Llc Methods and systems for fat reduction and/or cellulite treatment
US8690778B2 (en) 2004-10-06 2014-04-08 Guided Therapy Systems, Llc Energy-based tissue tightening
US8708935B2 (en) 2004-09-16 2014-04-29 Guided Therapy Systems, Llc System and method for variable depth ultrasound treatment
US8715186B2 (en) 2009-11-24 2014-05-06 Guided Therapy Systems, Llc Methods and systems for generating thermal bubbles for improved ultrasound imaging and therapy
CN103800955A (en) * 2012-11-09 2014-05-21 苏州工业园区职业技术学院 Ultrasonic wave trauma cleaning equipment
US8764687B2 (en) 2007-05-07 2014-07-01 Guided Therapy Systems, Llc Methods and systems for coupling and focusing acoustic energy using a coupler member
US8857438B2 (en) 2010-11-08 2014-10-14 Ulthera, Inc. Devices and methods for acoustic shielding
US8858471B2 (en) 2011-07-10 2014-10-14 Guided Therapy Systems, Llc Methods and systems for ultrasound treatment
US8915870B2 (en) 2004-10-06 2014-12-23 Guided Therapy Systems, Llc Method and system for treating stretch marks
US9011336B2 (en) 2004-09-16 2015-04-21 Guided Therapy Systems, Llc Method and system for combined energy therapy profile
US9011337B2 (en) 2011-07-11 2015-04-21 Guided Therapy Systems, Llc Systems and methods for monitoring and controlling ultrasound power output and stability
USD733319S1 (en) 2014-01-10 2015-06-30 Celleration, Inc. Ultrasonic treatment wand
USD733321S1 (en) 2014-01-10 2015-06-30 Celleration, Inc. Ultrasonic treatment device
US9114247B2 (en) 2004-09-16 2015-08-25 Guided Therapy Systems, Llc Method and system for ultrasound treatment with a multi-directional transducer
US9149658B2 (en) 2010-08-02 2015-10-06 Guided Therapy Systems, Llc Systems and methods for ultrasound treatment
US9216276B2 (en) 2007-05-07 2015-12-22 Guided Therapy Systems, Llc Methods and systems for modulating medicants using acoustic energy
US9241683B2 (en) 2006-10-04 2016-01-26 Ardent Sound Inc. Ultrasound system and method for imaging and/or measuring displacement of moving tissue and fluid
US9263663B2 (en) 2012-04-13 2016-02-16 Ardent Sound, Inc. Method of making thick film transducer arrays
US9504446B2 (en) 2010-08-02 2016-11-29 Guided Therapy Systems, Llc Systems and methods for coupling an ultrasound source to tissue
US9510802B2 (en) 2012-09-21 2016-12-06 Guided Therapy Systems, Llc Reflective ultrasound technology for dermatological treatments
US9694212B2 (en) 2004-10-06 2017-07-04 Guided Therapy Systems, Llc Method and system for ultrasound treatment of skin
US9744315B1 (en) * 2016-11-28 2017-08-29 Heat In A Click LLC Skin treatment apparatus
US9827449B2 (en) 2004-10-06 2017-11-28 Guided Therapy Systems, L.L.C. Systems for treating skin laxity

Families Citing this family (84)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7128719B2 (en) * 2000-08-03 2006-10-31 Mediwound Ltd. System for enhanced chemical debridement
US6964647B1 (en) * 2000-10-06 2005-11-15 Ellaz Babaev Nozzle for ultrasound wound treatment
US7914470B2 (en) * 2001-01-12 2011-03-29 Celleration, Inc. Ultrasonic method and device for wound treatment
US6960173B2 (en) * 2001-01-30 2005-11-01 Eilaz Babaev Ultrasound wound treatment method and device using standing waves
US7544177B2 (en) * 2002-01-24 2009-06-09 The Regents Of The University Of California Aerosol device to deliver bioactive agent
US8001962B2 (en) * 2002-08-23 2011-08-23 Sheiman Ultrasonic Research Foundation Pty Ltd. Nebulizing and drug delivery device
US7934665B2 (en) * 2003-03-28 2011-05-03 Ultrasonic Systems Inc. Ultrasonic spray coating system
WO2004087336A9 (en) * 2003-03-28 2005-03-10 Ultrasonic Systems Ultrasonic spray coating system
US20060169202A1 (en) * 2003-03-28 2006-08-03 Erickson Stuart J Coating system
US20060058708A1 (en) * 2003-12-24 2006-03-16 Gill Heart Method and apparatus for ultrasonically increasing the transportation of therapeutic substances through tissue
US20040267234A1 (en) * 2003-04-16 2004-12-30 Gill Heart Implantable ultrasound systems and methods for enhancing localized delivery of therapeutic substances
US20060241533A1 (en) * 2003-04-22 2006-10-26 Benjamin Geller Apparatus and method for treatment of damaged tissue
US8368867B2 (en) * 2004-12-31 2013-02-05 Lg Display Co., Ltd. Liquid crystal spraying apparatus with ultrasonic converter within nozzle and method for manufacturing of liquid crystal display device using the same
US7721729B2 (en) * 2005-03-09 2010-05-25 Ric Investments, Llc Nebulizing drug delivery device for ventilator
US7814901B2 (en) * 2005-03-09 2010-10-19 Ric Investments, Llc Nebulizing drug delivery device with increased flow rate
US8056557B2 (en) * 2005-03-09 2011-11-15 Ric Investments, Llc Nebulizing drug delivery device with barrier
US7631643B2 (en) * 2005-03-09 2009-12-15 Ric Investments, Llc Nebulizing drug delivery device with interlock detection and temperature protection
ES2369034T3 (en) 2005-05-23 2011-11-24 Biosonic Australia Pty. Ltd. Apparatus for atomizing and liquid filtration.
US7713218B2 (en) 2005-06-23 2010-05-11 Celleration, Inc. Removable applicator nozzle for ultrasound wound therapy device
US7785277B2 (en) 2005-06-23 2010-08-31 Celleration, Inc. Removable applicator nozzle for ultrasound wound therapy device
US9101949B2 (en) 2005-08-04 2015-08-11 Eilaz Babaev Ultrasonic atomization and/or seperation system
US7896539B2 (en) 2005-08-16 2011-03-01 Bacoustics, Llc Ultrasound apparatus and methods for mixing liquids and coating stents
US7842032B2 (en) * 2005-10-13 2010-11-30 Bacoustics, Llc Apparatus and methods for the selective removal of tissue
US7572268B2 (en) * 2005-10-13 2009-08-11 Bacoustics, Llc Apparatus and methods for the selective removal of tissue using combinations of ultrasonic energy and cryogenic energy
US20070167825A1 (en) * 2005-11-30 2007-07-19 Warren Lee Apparatus for catheter tips, including mechanically scanning ultrasound probe catheter tip
US20070167824A1 (en) * 2005-11-30 2007-07-19 Warren Lee Method of manufacture of catheter tips, including mechanically scanning ultrasound probe catheter tip, and apparatus made by the method
US20070167826A1 (en) * 2005-11-30 2007-07-19 Warren Lee Apparatuses for thermal management of actuated probes, such as catheter distal ends
EP1804308B1 (en) * 2005-12-23 2012-04-04 Novaled AG An organic light emitting device with a plurality of organic electroluminescent units stacked upon each other
US7691101B2 (en) * 2006-01-06 2010-04-06 Arthrocare Corporation Electrosurgical method and system for treating foot ulcer
US8876746B2 (en) 2006-01-06 2014-11-04 Arthrocare Corporation Electrosurgical system and method for treating chronic wound tissue
US8920849B1 (en) * 2006-03-30 2014-12-30 Kenneth P. Callison Skin treatment method and system
US7662177B2 (en) 2006-04-12 2010-02-16 Bacoustics, Llc Apparatus and methods for pain relief using ultrasound waves in combination with cryogenic energy
US20100313883A1 (en) * 2006-04-20 2010-12-16 Koninklijke Philips Electronics N.V. Ultrasonic bebulilzer with metal coated ultrasonic genrator
EP2020943B1 (en) 2006-05-30 2015-07-08 ArthroCare Corporation Hard tissue ablation system
US7431704B2 (en) * 2006-06-07 2008-10-07 Bacoustics, Llc Apparatus and method for the treatment of tissue with ultrasound energy by direct contact
US8562547B2 (en) 2006-06-07 2013-10-22 Eliaz Babaev Method for debriding wounds
EP2035082A4 (en) * 2006-06-07 2012-02-08 Trinity Wound Inst Llc Oxygen therapy with ultrasound
US20080039727A1 (en) * 2006-08-08 2008-02-14 Eilaz Babaev Ablative Cardiac Catheter System
KR20090068214A (en) * 2006-08-25 2009-06-25 에이라즈 피. 바베브 Portable ultrasound device for the treatment of wounds
US20080097252A1 (en) * 2006-08-25 2008-04-24 Eilaz Babaev Ultrasound and Pressure Therapy Wound Care Device
US20080167584A1 (en) * 2007-01-04 2008-07-10 Lenhardt Martin L Transdermal ultrasonic antimicrobial treatment and method
GB2452103B (en) 2007-01-05 2011-08-31 Arthrocare Corp Electrosurgical system with suction control apparatus and system
US20080265056A1 (en) * 2007-04-30 2008-10-30 Ke-Ming Quan Ultrasonic spray apparatus to coat a substrate
US20080265052A1 (en) * 2007-04-30 2008-10-30 Ke-Ming Quan Method of using an ultrasonic spray apparatus to coat a substrate
US7753285B2 (en) 2007-07-13 2010-07-13 Bacoustics, Llc Echoing ultrasound atomization and/or mixing system
US7896854B2 (en) * 2007-07-13 2011-03-01 Bacoustics, Llc Method of treating wounds by creating a therapeutic solution with ultrasonic waves
US7780095B2 (en) 2007-07-13 2010-08-24 Bacoustics, Llc Ultrasound pumping apparatus
US7901388B2 (en) 2007-07-13 2011-03-08 Bacoustics, Llc Method of treating wounds by creating a therapeutic solution with ultrasonic waves
US20090093870A1 (en) * 2007-10-05 2009-04-09 Bacoustics, Llc Method for Holding a Medical Device During Coating
US8689728B2 (en) * 2007-10-05 2014-04-08 Menendez Adolfo Apparatus for holding a medical device during coating
US20090098015A1 (en) * 2007-10-15 2009-04-16 Bhardwaj Mahesh C Ultrasonic Breathing and Respiratory System and Method
US20090099486A1 (en) * 2007-10-16 2009-04-16 Bhardwaj Mahesh C Ultrasonically Gas-Charged Reaction Accelerator
US9358063B2 (en) 2008-02-14 2016-06-07 Arthrocare Corporation Ablation performance indicator for electrosurgical devices
EP2274039A2 (en) 2008-05-06 2011-01-19 Wilson-Cook Medical Inc. Apparatus and methods for delivering therapeutic agents
US8048095B2 (en) * 2008-06-09 2011-11-01 Bacoustics, Llc Ultrasound liquid blade scalpel device
US20090306694A1 (en) * 2008-06-10 2009-12-10 Eilaz Babaev Ultrasound Liquid Blade Scalpel Method
CN105126262A (en) * 2008-07-14 2015-12-09 代理并代表亚利桑那州立大学的亚利桑那董事会 Methods and devices for modulating cellular activity using ultrasound
US8323220B2 (en) * 2008-09-19 2012-12-04 Eilaz Babaev Spider vein treatment apparatus
US8376969B2 (en) * 2008-09-22 2013-02-19 Bacoustics, Llc Methods for treatment of spider veins
JP5631332B2 (en) 2008-12-23 2014-11-26 クック メディカル テクノロジーズ エルエルシーCook Medical Technologies Llc Apparatus and method for accommodating and delivering a therapeutic agent
US8574187B2 (en) 2009-03-09 2013-11-05 Arthrocare Corporation System and method of an electrosurgical controller with output RF energy control
US9101744B2 (en) 2009-05-29 2015-08-11 Cook Medical Technologies Llc Systems and methods for delivering therapeutic agents
US8118777B2 (en) 2009-05-29 2012-02-21 Cook Medical Technologies Llc Systems and methods for delivering therapeutic agents
US8257350B2 (en) 2009-06-17 2012-09-04 Arthrocare Corporation Method and system of an electrosurgical controller with wave-shaping
US20110112394A1 (en) * 2009-11-11 2011-05-12 Mishelevich David J Neuromodulation of deep-brain targets using focused ultrasound
US20110130615A1 (en) * 2009-12-02 2011-06-02 Mishelevich David J Multi-modality neuromodulation of brain targets
US8372067B2 (en) 2009-12-09 2013-02-12 Arthrocare Corporation Electrosurgery irrigation primer systems and methods
US20110172591A1 (en) * 2010-01-13 2011-07-14 Bacoustics Llc Portable topical hyperbaric skin therapy and wound treatment system
US20110178442A1 (en) * 2010-01-18 2011-07-21 Mishelevich David J Patient feedback for control of ultrasound deep-brain neuromodulation
US20110190668A1 (en) * 2010-02-03 2011-08-04 Mishelevich David J Ultrasound neuromodulation of the sphenopalatine ganglion
US8747399B2 (en) 2010-04-06 2014-06-10 Arthrocare Corporation Method and system of reduction of low frequency muscle stimulation during electrosurgical procedures
US8685018B2 (en) 2010-10-15 2014-04-01 Arthrocare Corporation Electrosurgical wand and related method and system
US9131597B2 (en) 2011-02-02 2015-09-08 Arthrocare Corporation Electrosurgical system and method for treating hard body tissue
CN102836471A (en) * 2011-06-20 2012-12-26 重庆腾跃医疗器械有限公司 Multifunctional ultrasonic debridement treatment machine
EP2768385A4 (en) 2011-10-21 2015-09-23 Thync Inc Method and system for direct communication
RU2481160C1 (en) * 2011-11-18 2013-05-10 Общество с ограниченной ответственностью "Центр ультразвуковых технологий АлтГТУ" Ultrasound sprayer
US20130264397A1 (en) * 2012-04-09 2013-10-10 Stuart J. Erickson Spray Head Improvements for an Ultrasonic Spray Coating Assembly
US9693818B2 (en) 2013-03-07 2017-07-04 Arthrocare Corporation Methods and systems related to electrosurgical wands
US9713489B2 (en) 2013-03-07 2017-07-25 Arthrocare Corporation Electrosurgical methods and systems
US9801678B2 (en) 2013-03-13 2017-10-31 Arthrocare Corporation Method and system of controlling conductive fluid flow during an electrosurgical procedure
US9867931B2 (en) 2013-10-02 2018-01-16 Cook Medical Technologies Llc Therapeutic agents for delivery using a catheter and pressure source
US9597702B1 (en) * 2013-10-03 2017-03-21 Sonaer, Inc. Ultrasonic cosmetic applicator
US9282803B2 (en) * 2013-10-03 2016-03-15 Donald John Ciervo Ultrasonic cosmetic applicator
CA3001884A1 (en) * 2015-10-30 2017-05-04 Johnson & Johnson Consumer Inc. Aseptic aerosol misting device

Family Cites Families (135)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB807080A (en) * 1956-02-28 1959-01-07 Technical Ceramics Ltd Ultrasonic spray
US3275059A (en) 1965-05-10 1966-09-27 Little Inc A Nozzle system and fuel oil burner incorporating it
US3392916A (en) 1965-12-08 1968-07-16 Carl Gunnar Daniel Engstrom Ultrasonic atomizer
US3561444A (en) 1968-05-22 1971-02-09 Bio Logics Inc Ultrasonic drug nebulizer
US3860173A (en) 1970-02-03 1975-01-14 Naoyasu Sata Non-polluting combustion engine having ultrasonic fuel atomizer in place of carburetor
US4085893A (en) 1974-03-20 1978-04-25 Durley Iii Benton A Ultrasonic humidifiers, atomizers and the like
GB1496086A (en) 1975-02-19 1977-12-21 Plessey Co Ltd Vibratory atomizer
US4309989A (en) 1976-02-09 1982-01-12 The Curators Of The University Of Missouri Topical application of medication by ultrasound with coupling agent
US4301968A (en) 1976-11-08 1981-11-24 Sono-Tek Corporation Transducer assembly, ultrasonic atomizer and fuel burner
US4153201A (en) 1976-11-08 1979-05-08 Sono-Tek Corporation Transducer assembly, ultrasonic atomizer and fuel burner
DE2811248C3 (en) 1978-03-15 1981-11-26 Bosch-Siemens Hausgeraete Gmbh, 7000 Stuttgart, De
FR2443113B1 (en) 1978-06-30 1985-12-06 Deutsch Pruef Messgeraete Method and device for emitting acoustic pulses, particularly in the field of ultrasound, and application of these pulses including non-destructive testing of materials
GB2029270B (en) 1978-07-11 1982-11-03 Plessey Co Ltd Vibratory atomiser
DE2854841C2 (en) 1978-12-19 1981-03-26 Bosch-Siemens Hausgeraete Gmbh, 7000 Stuttgart, De
JPS5848225B2 (en) 1979-01-09 1983-10-27 Omron Tateisi Electronics Co
DE7917568U1 (en) 1979-06-19 1979-09-20 Bosch-Siemens Hausgeraete Gmbh, 7000 Stuttgart Inhalationsgeraet
GB2058209B (en) 1979-09-11 1983-04-27 Plessey Co Ltd Method of producing a fuel injector for an engine
US4352459A (en) 1979-11-13 1982-10-05 Sono-Tek Corporation Ultrasonic liquid atomizer having an axially-extending liquid feed passage
NL8202262A (en) 1981-06-06 1983-01-03 Rowenta Werke Gmbh Transport for ultrasonic respirators and the like.
NL8202263A (en) 1981-06-06 1983-01-03 Rowenta Werke Gmbh Ultrasonic respirator.
DE3124854C2 (en) 1981-06-24 1985-03-14 Reinhard 8057 Eching De Muehlbauer
US4530360A (en) 1981-11-19 1985-07-23 Duarte Luiz R Method for healing bone fractures with ultrasound
US4541564A (en) 1983-01-05 1985-09-17 Sono-Tek Corporation Ultrasonic liquid atomizer, particularly for high volume flow rates
US4655393A (en) 1983-01-05 1987-04-07 Sonotek Corporation High volume ultrasonic liquid atomizer
GB8316051D0 (en) 1983-06-13 1983-07-20 Shell Int Research Atomiser
EP0156409A3 (en) 1984-02-23 1986-06-25 Jean Michel Anthony Device for moistening parts of the human body
JPS6316582B2 (en) 1984-04-19 1988-04-09 Toa Nenryo Kogyo Kk
EP0173334B1 (en) 1984-08-29 1989-11-23 Omron Tateisi Electronics Co. Ultrasonic atomizer
EP0174033B1 (en) 1984-09-07 1991-03-27 Omron Tateisi Electronics Co. Oscillating construction for an ultrasonic atomizing inhaler
US4582654A (en) 1984-09-12 1986-04-15 Varian Associates, Inc. Nebulizer particularly adapted for analytical purposes
US4726523A (en) 1984-12-11 1988-02-23 Toa Nenryo Kogyo Kabushiki Kaisha Ultrasonic injection nozzle
JPH0229388B2 (en) 1984-12-11 1990-06-29 Toa Nenryo Kogyo Kk Choonpafunshanozuruyoshindoshi
JPH0256943B2 (en) 1984-12-11 1990-12-03 Toa Nenryo Kogyo Kk
JPS61259784A (en) 1985-05-13 1986-11-18 Toa Nenryo Kogyo Kk Vibrator for ultrasonic injection
US4642581A (en) 1985-06-21 1987-02-10 Sono-Tek Corporation Ultrasonic transducer drive circuit
US4659014A (en) 1985-09-05 1987-04-21 Delavan Corporation Ultrasonic spray nozzle and method
US4723708A (en) * 1986-05-09 1988-02-09 Sono-Tek Corporation Central bolt ultrasonic atomizer
US4941618A (en) 1986-07-07 1990-07-17 Leeman Labs Inc. Nebulizer employing a fine mesh screen
JPS6338193A (en) * 1986-08-01 1988-02-18 Toa Nenryo Kogyo Kk Ultrasonic vibrator horn
DE3627222A1 (en) 1986-08-11 1988-02-18 Siemens Ag Ultrasonic taschenzerstaeubergeraet
US5104042A (en) 1986-08-27 1992-04-14 Atochem North America, Inc. Ultrasonic dispersion nozzle with internal shut-off mechanism having barrier-fluid separation means incorporated therewith
US4930700A (en) 1986-08-27 1990-06-05 Atochem North America Ultrasonic dispersion nozzle having internal shut-off mechanism with barrier fluid separation
US4850534A (en) 1987-05-30 1989-07-25 Tdk Corporation Ultrasonic wave nebulizer
US5040537A (en) 1987-11-24 1991-08-20 Hitachi, Ltd. Method and apparatus for the measurement and medical treatment using an ultrasonic wave
DE3741201A1 (en) 1987-12-02 1989-06-15 Schering Ag IMPLEMENTATION ultrasonic working method and medium for its
FI82808C (en) 1987-12-31 1991-04-25 Etelae Haemeen Keuhkovammayhdi Ultraljudfinfoerdelningsanordning.
US4905671A (en) 1988-01-11 1990-03-06 Dornier Medizintechnik Gmbh Inducement of bone growth by acoustic shock waves
US5186162A (en) 1988-09-14 1993-02-16 Interpore Orthopaedics, Inc. Ultrasonic transducer device for treatment of living tissue and/or cells
US5211160A (en) 1988-09-14 1993-05-18 Interpore Orthopaedics, Inc. Ultrasonic orthopedic treatment head and body-mounting means therefor
EP0373237A1 (en) 1988-12-13 1990-06-20 Siemens Aktiengesellschaft Pocket inhaler device
WO1990012655A1 (en) 1989-04-14 1990-11-01 Azerbaidzhansky Politekhnichesky Institut Imeni Ch.Ildryma Device for ultrasonic dispersion of a liquid medium
US5002059A (en) 1989-07-26 1991-03-26 Boston Scientific Corporation Tip filled ultrasound catheter
US5163433A (en) 1989-11-01 1992-11-17 Olympus Optical Co., Ltd. Ultrasound type treatment apparatus
US4961885A (en) 1989-11-24 1990-10-09 Elecsys Ltd. Ultrasonic nebulizer
FR2655279B1 (en) 1989-12-01 1993-09-17 Anios Lab Sarl Process for micro-spraying a solution by ultra-sound and micro-droplet diffuser óoeuvre using said device.
US5231975A (en) 1990-02-23 1993-08-03 Cygnus Therapeutic Systems Ultrasound-enhanced delivery of materials into and through the skin
US5115805A (en) 1990-02-23 1992-05-26 Cygnus Therapeutic Systems Ultrasound-enhanced delivery of materials into and through the skin
US5197946A (en) 1990-06-27 1993-03-30 Shunro Tachibana Injection instrument with ultrasonic oscillating element
GB9015077D0 (en) 1990-07-09 1990-08-29 Riker Laboratories Inc Inhaler
FR2665849B1 (en) * 1990-08-20 1995-03-24 Dynamad Ultrasonic device for the continuous production of particles.
US5172692A (en) 1990-12-05 1992-12-22 Kulow Howard H Method for inflammatory response management
US5269291A (en) 1990-12-10 1993-12-14 Coraje, Inc. Miniature ultrasonic transducer for plaque ablation
US5324255A (en) 1991-01-11 1994-06-28 Baxter International Inc. Angioplasty and ablative devices having onboard ultrasound components and devices and methods for utilizing ultrasound to treat or prevent vasopasm
DE69430303T2 (en) 1991-03-05 2002-11-28 Aradigm Corp A method and apparatus for correcting a zero signal of a pressure sensor for a flow meter
US5316000A (en) 1991-03-05 1994-05-31 Technomed International (Societe Anonyme) Use of at least one composite piezoelectric transducer in the manufacture of an ultrasonic therapy apparatus for applying therapy, in a body zone, in particular to concretions, to tissue, or to bones, of a living being and method of ultrasonic therapy
DE69215722D1 (en) * 1991-03-22 1997-01-23 Katsuro Tachibana Amplifier for ultrasonic therapy of diseases as well as those containing liquid pharmaceutical compositions
US5325860A (en) 1991-11-08 1994-07-05 Mayo Foundation For Medical Education And Research Ultrasonic and interventional catheter and method
GB2291605B (en) * 1991-11-12 1996-05-01 Medix Ltd A nebuliser and nebuliser control system
US5374266A (en) 1991-11-27 1994-12-20 Kabushiki Kaisha Morita Seisakusho Medical laser treatment device
US5529572A (en) 1992-01-24 1996-06-25 Medispec Ltd. Method and apparatus particularly useful for treating osteoporosis
US5993389A (en) 1995-05-22 1999-11-30 Ths International, Inc. Devices for providing acoustic hemostasis
US5362309A (en) 1992-09-14 1994-11-08 Coraje, Inc. Apparatus and method for enhanced intravascular phonophoresis including dissolution of intravascular blockage and concomitant inhibition of restenosis
US5318014A (en) 1992-09-14 1994-06-07 Coraje, Inc. Ultrasonic ablation/dissolution transducer
US5393296A (en) 1992-12-09 1995-02-28 Siemens Aktiengesellschaft Method for the medical treatment of pathologic bone
US5558085A (en) 1993-01-29 1996-09-24 Aradigm Corporation Intrapulmonary delivery of peptide drugs
US6098620A (en) 1993-01-29 2000-08-08 Aradigm Corporation Device for aerosolizing narcotics
US5527350A (en) 1993-02-24 1996-06-18 Star Medical Technologies, Inc. Pulsed infrared laser treatment of psoriasis
US5707403A (en) 1993-02-24 1998-01-13 Star Medical Technologies, Inc. Method for the laser treatment of subsurface blood vessels
DE4315282C2 (en) 1993-05-07 1999-10-07 Siemens Ag Using an acoustic pressure pulse source
US5894841A (en) 1993-06-29 1999-04-20 Ponwell Enterprises Limited Dispenser
DE59409409D1 (en) 1993-08-09 2000-08-03 Siemens Ag inhaler
GB9324250D0 (en) 1993-11-25 1994-01-12 Minnesota Mining & Mfg Inhaler
EP0657226B1 (en) 1993-12-10 1998-02-04 Siemens Aktiengesellschaft Ultrasonic sprayer
US5570682A (en) 1993-12-14 1996-11-05 Ethex International, Inc. Passive inspiratory nebulizer system
JPH07184907A (en) 1993-12-28 1995-07-25 Toshiba Corp Ultrasonic treating device
US5616140A (en) 1994-03-21 1997-04-01 Prescott; Marvin Method and apparatus for therapeutic laser treatment
US5989245A (en) 1994-03-21 1999-11-23 Prescott; Marvin A. Method and apparatus for therapeutic laser treatment
US5437606A (en) 1994-03-28 1995-08-01 Tsukamoto; Kenichi Ultrasonic system to alleviate toothaches
US5516043A (en) 1994-06-30 1996-05-14 Misonix Inc. Ultrasonic atomizing device
US6113570A (en) 1994-09-09 2000-09-05 Coraje, Inc. Method of removing thrombosis in fistulae
US5547459A (en) 1994-10-25 1996-08-20 Orthologic Corporation Ultrasonic bone-therapy apparatus and method
US5573497A (en) 1994-11-30 1996-11-12 Technomed Medical Systems And Institut National High-intensity ultrasound therapy method and apparatus with controlled cavitation effect and reduced side lobes
US5520612A (en) 1994-12-30 1996-05-28 Exogen, Inc. Acoustic system for bone-fracture therapy
US5556372A (en) 1995-02-15 1996-09-17 Exogen, Inc. Apparatus for ultrasonic bone treatment
US5626554A (en) 1995-02-21 1997-05-06 Exogen, Inc. Gel containment structure
US5554172A (en) 1995-05-09 1996-09-10 The Larren Corporation Directed energy surgical method and assembly
US5730705A (en) 1995-06-12 1998-03-24 Talish; Roger J. Ultrasonic treatment for bony ingrowth
US5658323A (en) 1995-07-12 1997-08-19 Miller; Iain D. Method and apparatus for dermatology treatment
US5879376A (en) 1995-07-12 1999-03-09 Luxar Corporation Method and apparatus for dermatology treatment
WO1997017933A1 (en) * 1995-11-15 1997-05-22 Aeropag Usa, Inc. Method of spraying a surface using ultrasonic radiation
US5735811A (en) 1995-11-30 1998-04-07 Pharmasonics, Inc. Apparatus and methods for ultrasonically enhanced fluid delivery
US6041253A (en) 1995-12-18 2000-03-21 Massachusetts Institute Of Technology Effect of electric field and ultrasound for transdermal drug delivery
US5947921A (en) 1995-12-18 1999-09-07 Massachusetts Institute Of Technology Chemical and physical enhancers and ultrasound for transdermal drug delivery
US5683432A (en) 1996-01-11 1997-11-04 Medtronic, Inc. Adaptive, performance-optimizing communication system for communicating with an implanted medical device
DE69733815T2 (en) 1996-02-15 2006-06-08 Biosense Webster, Inc., Diamond Bar Probe for excavation
US5895362A (en) 1996-02-23 1999-04-20 Abbott Laboratories Transdermal transport using ultrasonic standing waves
US5762616A (en) 1996-03-15 1998-06-09 Exogen, Inc. Apparatus for ultrasonic treatment of sites corresponding to the torso
US5656016A (en) 1996-03-18 1997-08-12 Abbott Laboratories Sonophoretic drug delivery system
US5746756A (en) 1996-06-03 1998-05-05 Ethicon Endo-Surgery, Inc. Internal ultrasonic tip amplifier
US5699805A (en) 1996-06-20 1997-12-23 Mayo Foundation For Medical Education And Research Longitudinal multiplane ultrasound transducer underfluid catheter system
US6234990B1 (en) 1996-06-28 2001-05-22 Sontra Medical, Inc. Ultrasound enhancement of transdermal transport
US6024718A (en) 1996-09-04 2000-02-15 The Regents Of The University Of California Intraluminal directed ultrasound delivery device
US5835678A (en) 1996-10-03 1998-11-10 Emcore Corporation Liquid vaporizer system and method
CA2272647A1 (en) * 1996-11-27 1998-06-04 Shun K. Lee Compound delivery using impulse transients
US5785972A (en) * 1997-01-10 1998-07-28 Tyler; Kathleen A. Colloidal silver, honey, and helichrysum oil antiseptic composition and method of application
US5904659A (en) 1997-02-14 1999-05-18 Exogen, Inc. Ultrasonic treatment for wounds
WO1998047568A1 (en) 1997-04-18 1998-10-29 Exogen, Inc. Apparatus for ultrasonic bone treatment
WO1998048711A1 (en) 1997-05-01 1998-11-05 Ekos Corporation Ultrasound catheter
DE19718513C5 (en) 1997-05-02 2010-06-02 Sanuwave, Inc., Device for generating acoustic shock waves, in particular for medical use
US5879314A (en) 1997-06-30 1999-03-09 Cybersonics, Inc. Transducer assembly and method for coupling ultrasonic energy to a body for thrombolysis of vascular thrombi
DE19733838C2 (en) 1997-08-04 2001-06-13 Hmt Ag An apparatus for treating with acoustic shock waves
US6113558A (en) 1997-09-29 2000-09-05 Angiosonics Inc. Pulsed mode lysis method
US5954047A (en) 1997-10-17 1999-09-21 Systemic Pulmonary Development, Ltd. Methods and apparatus for delivering aerosolized medication
US6007499A (en) 1997-10-31 1999-12-28 University Of Washington Method and apparatus for medical procedures using high-intensity focused ultrasound
JP2002500075A (en) 1998-01-08 2002-01-08 ソントラ メディカル, インコーポレイテッド Transdermal transport is enhanced by ultrasonic transmission
US6158431A (en) 1998-02-13 2000-12-12 Tsi Incorporated Portable systems and methods for delivery of therapeutic material to the pulmonary system
US6102298A (en) 1998-02-23 2000-08-15 The Procter & Gamble Company Ultrasonic spray coating application system
US6014970A (en) 1998-06-11 2000-01-18 Aerogen, Inc. Methods and apparatus for storing chemical compounds in a portable inhaler
US6206842B1 (en) 1998-08-03 2001-03-27 Lily Chen Tu Ultrasonic operation device
US6106547A (en) 1998-09-22 2000-08-22 Huei-Jung; Lien Hot/cold dual-mold skin treatment apparatus
US6061597A (en) 1998-12-18 2000-05-09 Robert D. Rieman Method and device for healing bone fractures
US6325769B1 (en) 1998-12-29 2001-12-04 Collapeutics, Llc Method and apparatus for therapeutic treatment of skin
US6231528B1 (en) 1999-01-15 2001-05-15 Jonathan J. Kaufman Ultrasonic and growth factor bone-therapy: apparatus and method
US6206843B1 (en) 1999-01-28 2001-03-27 Ultra Cure Ltd. Ultrasound system and methods utilizing same
JP2000237275A (en) 1999-02-24 2000-09-05 Ya Man Ltd Ultrasonic mist generating apparatus

Cited By (130)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8123707B2 (en) 1997-02-06 2012-02-28 Exogen, Inc. Method and apparatus for connective tissue treatment
US7789841B2 (en) 1997-02-06 2010-09-07 Exogen, Inc. Method and apparatus for connective tissue treatment
US20020016557A1 (en) * 1997-02-14 2002-02-07 Duarte Luiz R. Ultrasonic treatment for wounds
US9272162B2 (en) 1997-10-14 2016-03-01 Guided Therapy Systems, Llc Imaging, therapy, and temperature monitoring ultrasonic method
US8480585B2 (en) 1997-10-14 2013-07-09 Guided Therapy Systems, Llc Imaging, therapy and temperature monitoring ultrasonic system and method
US20060184071A1 (en) * 1997-12-29 2006-08-17 Julia Therapeutics, Llc Treatment of skin with acoustic energy
US20080027328A1 (en) * 1997-12-29 2008-01-31 Julia Therapeutics, Llc Multi-focal treatment of skin with acoustic energy
US7440798B2 (en) 2000-08-24 2008-10-21 Redding Jr Bruce K Substance delivery system
US20050131359A1 (en) * 2000-08-24 2005-06-16 Redding Bruce K.Jr. Substance delivery system
US20050038377A1 (en) * 2000-08-24 2005-02-17 Redding Bruce K. Ultrasonically enhanced substance delivery system and device
US9907535B2 (en) 2000-12-28 2018-03-06 Ardent Sound, Inc. Visual imaging system for ultrasonic probe
US8409097B2 (en) 2000-12-28 2013-04-02 Ardent Sound, Inc Visual imaging system for ultrasonic probe
US8235919B2 (en) 2001-01-12 2012-08-07 Celleration, Inc. Ultrasonic method and device for wound treatment
US7819918B2 (en) * 2001-07-16 2010-10-26 Depuy Products, Inc. Implantable tissue repair device
US20050075599A1 (en) * 2001-08-24 2005-04-07 Redding Bruce K. Ultrasonically enhanced saline treatment for burn damaged skin
US20060015059A1 (en) * 2002-01-16 2006-01-19 Redding Bruce K Jr Substance delivery device
US7472850B2 (en) 2003-06-18 2009-01-06 Abb Patent Gmbh Ultrasonic standing-wave atomizer arrangement
US20070012797A1 (en) * 2003-06-18 2007-01-18 Abb Patent Gmbh Standing ultrasonic wave spraying arrangement
WO2004110649A1 (en) * 2003-06-18 2004-12-23 Abb Patent Gmbh Standing ultrasonic wave spraying arrangement
US8235909B2 (en) 2004-05-12 2012-08-07 Guided Therapy Systems, L.L.C. Method and system for controlled scanning, imaging and/or therapy
US9114247B2 (en) 2004-09-16 2015-08-25 Guided Therapy Systems, Llc Method and system for ultrasound treatment with a multi-directional transducer
US9011336B2 (en) 2004-09-16 2015-04-21 Guided Therapy Systems, Llc Method and system for combined energy therapy profile
US8708935B2 (en) 2004-09-16 2014-04-29 Guided Therapy Systems, Llc System and method for variable depth ultrasound treatment
US9895560B2 (en) 2004-09-24 2018-02-20 Guided Therapy Systems, Llc Methods for rejuvenating skin by heating tissue for cosmetic treatment of the face and body
US9095697B2 (en) 2004-09-24 2015-08-04 Guided Therapy Systems, Llc Methods for preheating tissue for cosmetic treatment of the face and body
US20090005710A1 (en) * 2004-10-01 2009-01-01 Duplogen, Inc. Ultrasonic Equipment for Treatment of Osteoarthritis
US9694212B2 (en) 2004-10-06 2017-07-04 Guided Therapy Systems, Llc Method and system for ultrasound treatment of skin
US9694211B2 (en) 2004-10-06 2017-07-04 Guided Therapy Systems, L.L.C. Systems for treating skin laxity
US9700340B2 (en) 2004-10-06 2017-07-11 Guided Therapy Systems, Llc System and method for ultra-high frequency ultrasound treatment
US9533175B2 (en) 2004-10-06 2017-01-03 Guided Therapy Systems, Llc Energy based fat reduction
US9522290B2 (en) 2004-10-06 2016-12-20 Guided Therapy Systems, Llc System and method for fat and cellulite reduction
US9827450B2 (en) 2004-10-06 2017-11-28 Guided Therapy Systems, L.L.C. System and method for fat and cellulite reduction
US9440096B2 (en) 2004-10-06 2016-09-13 Guided Therapy Systems, Llc Method and system for treating stretch marks
US9427600B2 (en) 2004-10-06 2016-08-30 Guided Therapy Systems, L.L.C. Systems for treating skin laxity
US9827449B2 (en) 2004-10-06 2017-11-28 Guided Therapy Systems, L.L.C. Systems for treating skin laxity
US9421029B2 (en) 2004-10-06 2016-08-23 Guided Therapy Systems, Llc Energy based hyperhidrosis treatment
US9320537B2 (en) 2004-10-06 2016-04-26 Guided Therapy Systems, Llc Methods for noninvasive skin tightening
US9283409B2 (en) 2004-10-06 2016-03-15 Guided Therapy Systems, Llc Energy based fat reduction
US9283410B2 (en) 2004-10-06 2016-03-15 Guided Therapy Systems, L.L.C. System and method for fat and cellulite reduction
US9833639B2 (en) 2004-10-06 2017-12-05 Guided Therapy Systems, L.L.C. Energy based fat reduction
US9833640B2 (en) 2004-10-06 2017-12-05 Guided Therapy Systems, L.L.C. Method and system for ultrasound treatment of skin
US9707412B2 (en) 2004-10-06 2017-07-18 Guided Therapy Systems, Llc System and method for fat and cellulite reduction
US9039619B2 (en) 2004-10-06 2015-05-26 Guided Therapy Systems, L.L.C. Methods for treating skin laxity
US8915870B2 (en) 2004-10-06 2014-12-23 Guided Therapy Systems, Llc Method and system for treating stretch marks
US9713731B2 (en) 2004-10-06 2017-07-25 Guided Therapy Systems, Llc Energy based fat reduction
US8932224B2 (en) 2004-10-06 2015-01-13 Guided Therapy Systems, Llc Energy based hyperhidrosis treatment
US8920324B2 (en) 2004-10-06 2014-12-30 Guided Therapy Systems, Llc Energy based fat reduction
US9974982B2 (en) 2004-10-06 2018-05-22 Guided Therapy Systems, Llc System and method for noninvasive skin tightening
US10010721B2 (en) 2004-10-06 2018-07-03 Guided Therapy Systems, L.L.C. Energy based fat reduction
US8282554B2 (en) 2004-10-06 2012-10-09 Guided Therapy Systems, Llc Methods for treatment of sweat glands
US8333700B1 (en) 2004-10-06 2012-12-18 Guided Therapy Systems, L.L.C. Methods for treatment of hyperhidrosis
US8366622B2 (en) 2004-10-06 2013-02-05 Guided Therapy Systems, Llc Treatment of sub-dermal regions for cosmetic effects
US8535228B2 (en) 2004-10-06 2013-09-17 Guided Therapy Systems, Llc Method and system for noninvasive face lifts and deep tissue tightening
US8915854B2 (en) 2004-10-06 2014-12-23 Guided Therapy Systems, Llc Method for fat and cellulite reduction
US8444562B2 (en) 2004-10-06 2013-05-21 Guided Therapy Systems, Llc System and method for treating muscle, tendon, ligament and cartilage tissue
US8460193B2 (en) 2004-10-06 2013-06-11 Guided Therapy Systems Llc System and method for ultra-high frequency ultrasound treatment
US10010725B2 (en) 2004-10-06 2018-07-03 Guided Therapy Systems, Llc Ultrasound probe for fat and cellulite reduction
US8915853B2 (en) 2004-10-06 2014-12-23 Guided Therapy Systems, Llc Methods for face and neck lifts
US8506486B2 (en) 2004-10-06 2013-08-13 Guided Therapy Systems, Llc Ultrasound treatment of sub-dermal tissue for cosmetic effects
US8523775B2 (en) 2004-10-06 2013-09-03 Guided Therapy Systems, Llc Energy based hyperhidrosis treatment
US10010726B2 (en) 2004-10-06 2018-07-03 Guided Therapy Systems, Llc Ultrasound probe for treatment of skin
US8636665B2 (en) 2004-10-06 2014-01-28 Guided Therapy Systems, Llc Method and system for ultrasound treatment of fat
US8641622B2 (en) 2004-10-06 2014-02-04 Guided Therapy Systems, Llc Method and system for treating photoaged tissue
US8663112B2 (en) 2004-10-06 2014-03-04 Guided Therapy Systems, Llc Methods and systems for fat reduction and/or cellulite treatment
US8672848B2 (en) 2004-10-06 2014-03-18 Guided Therapy Systems, Llc Method and system for treating cellulite
US20060089632A1 (en) * 2004-10-06 2006-04-27 Guided Therapy Systems, L.L.C. Method and system for treating acne and sebaceous glands
US8690779B2 (en) 2004-10-06 2014-04-08 Guided Therapy Systems, Llc Noninvasive aesthetic treatment for tightening tissue
US8690780B2 (en) 2004-10-06 2014-04-08 Guided Therapy Systems, Llc Noninvasive tissue tightening for cosmetic effects
US9427601B2 (en) 2004-10-06 2016-08-30 Guided Therapy Systems, Llc Methods for face and neck lifts
US8690778B2 (en) 2004-10-06 2014-04-08 Guided Therapy Systems, Llc Energy-based tissue tightening
US10010724B2 (en) 2004-10-06 2018-07-03 Guided Therapy Systems, L.L.C. Ultrasound probe for treating skin laxity
US8166332B2 (en) 2005-04-25 2012-04-24 Ardent Sound, Inc. Treatment system for enhancing safety of computer peripheral for use with medical devices by isolating host AC power
US8868958B2 (en) 2005-04-25 2014-10-21 Ardent Sound, Inc Method and system for enhancing computer peripheral safety
US20080095920A1 (en) * 2005-08-04 2008-04-24 Eilaz Babaev Ultrasound medical device coating method
US20080146970A1 (en) * 2005-12-06 2008-06-19 Julia Therapeutics, Llc Gel dispensers for treatment of skin with acoustic energy
KR101117394B1 (en) * 2006-01-23 2012-03-07 케이씨아이 라이센싱 인코포레이티드 System for treating a wound using ultrasonic debridement
CN101360473B (en) 2006-01-23 2011-12-14 凯希特许有限公司 Using ultrasonic debridement of wound treatment system
US8075503B2 (en) 2006-01-23 2011-12-13 Kci Licensing, Inc. System and method for treating a wound using ultrasonic debridement
WO2007084792A3 (en) * 2006-01-23 2007-12-13 Kci Licensing Inc System and method for treating a wound using ultrasonic debribement
US7943352B2 (en) 2006-03-29 2011-05-17 Bacoustics, Llc Apparatus and methods for vaccine development using ultrasound technology
US7842249B2 (en) 2006-03-29 2010-11-30 Bacoustics, Llc Apparatus for vaccine development using ultrasound technology
WO2008024532A1 (en) * 2006-08-21 2008-02-28 Boston Scientific Scimed, Inc. Ultrasound catheter
US20080097316A1 (en) * 2006-08-21 2008-04-24 Leonid Malinin Ultrasound catheter
WO2008036622A2 (en) * 2006-09-18 2008-03-27 Guided Therapy Systems, Llc Method and system for non-ablative acne treatment and prevention
US20080294073A1 (en) * 2006-09-18 2008-11-27 Guided Therapy Systems, Inc. Method and sysem for non-ablative acne treatment and prevention
EP3056246A1 (en) * 2006-09-18 2016-08-17 Guided Therapy Systems, L.L.C. System for non-ablative acne treatment and prevention
US9566454B2 (en) 2006-09-18 2017-02-14 Guided Therapy Systems, Llc Method and sysem for non-ablative acne treatment and prevention
WO2008036622A3 (en) * 2006-09-18 2008-05-22 Peter G Barthe Method and system for non-ablative acne treatment and prevention
US8050752B2 (en) * 2006-09-29 2011-11-01 Bacoustics, Llc Method of treating lumens, cavities, and tissues of the body with an ultrasound delivered liquid
US20080119779A1 (en) * 2006-09-29 2008-05-22 Eilaz Babaev Method of Treating Lumens, Cavities, and Tissues of the Body with an Ultrasound Delivered Liquid.
US9241683B2 (en) 2006-10-04 2016-01-26 Ardent Sound Inc. Ultrasound system and method for imaging and/or measuring displacement of moving tissue and fluid
US20080128362A1 (en) * 2006-12-04 2008-06-05 Bacoustics Llc Method of ultrasonically treating a continuous flow of fluid
US7846341B2 (en) 2006-12-04 2010-12-07 Bacoustics, Llc Method of ultrasonically treating a continuous flow of fluid
US7871440B2 (en) 2006-12-11 2011-01-18 Depuy Products, Inc. Unitary surgical device and method
US20100063423A1 (en) * 2006-12-19 2010-03-11 Cedars-Sinai Medical Center Ultrasonic bath to increase tissue perfusion
US9050448B2 (en) * 2006-12-19 2015-06-09 Cedars-Sinai Medical Center Ultrasonic bath to increase tissue perfusion
US20150231416A1 (en) * 2006-12-19 2015-08-20 Board Of Regents Of The University Of Texas System Ultrasonic bath to increase tissue perfusion
US8491521B2 (en) * 2007-01-04 2013-07-23 Celleration, Inc. Removable multi-channel applicator nozzle
US20080243047A1 (en) * 2007-03-27 2008-10-02 Babaev Eilaz P Ultrasound wound care device
US9216276B2 (en) 2007-05-07 2015-12-22 Guided Therapy Systems, Llc Methods and systems for modulating medicants using acoustic energy
US8764687B2 (en) 2007-05-07 2014-07-01 Guided Therapy Systems, Llc Methods and systems for coupling and focusing acoustic energy using a coupler member
WO2008151277A1 (en) * 2007-06-05 2008-12-11 Julia Therapeutics, Llc Gel dispensers for treatment of skin with acoustic energy
US20090099485A1 (en) * 2007-10-16 2009-04-16 Sarvazyan Armen P Ultrasound standing wave method and apparatus for tissue treatment
US8016208B2 (en) 2008-02-08 2011-09-13 Bacoustics, Llc Echoing ultrasound atomization and mixing system
US7950594B2 (en) 2008-02-11 2011-05-31 Bacoustics, Llc Mechanical and ultrasound atomization and mixing system
US7830070B2 (en) 2008-02-12 2010-11-09 Bacoustics, Llc Ultrasound atomization system
US20090200390A1 (en) * 2008-02-12 2009-08-13 Eilaz Babaev Ultrasound atomization system
US20090312693A1 (en) * 2008-06-13 2009-12-17 Vytronus, Inc. System and method for delivering energy to tissue
US20090312673A1 (en) * 2008-06-14 2009-12-17 Vytronus, Inc. System and method for delivering energy to tissue
US20110226235A1 (en) * 2008-12-11 2011-09-22 Koninklijke Philips Electronics, N.V. System and method for monitoring nebulization of a medicament
US9821128B2 (en) 2008-12-11 2017-11-21 Koninklijke Philips N.V. System and method for monitoring nebulization of a medicament
WO2010067239A3 (en) * 2008-12-11 2010-08-05 Koninklijke Philips Electronics, N.V. System and method for monitoring nebulization of a medicament
US9039617B2 (en) 2009-11-24 2015-05-26 Guided Therapy Systems, Llc Methods and systems for generating thermal bubbles for improved ultrasound imaging and therapy
US9345910B2 (en) 2009-11-24 2016-05-24 Guided Therapy Systems Llc Methods and systems for generating thermal bubbles for improved ultrasound imaging and therapy
US8715186B2 (en) 2009-11-24 2014-05-06 Guided Therapy Systems, Llc Methods and systems for generating thermal bubbles for improved ultrasound imaging and therapy
US9149658B2 (en) 2010-08-02 2015-10-06 Guided Therapy Systems, Llc Systems and methods for ultrasound treatment
US9504446B2 (en) 2010-08-02 2016-11-29 Guided Therapy Systems, Llc Systems and methods for coupling an ultrasound source to tissue
US8857438B2 (en) 2010-11-08 2014-10-14 Ulthera, Inc. Devices and methods for acoustic shielding
US9452302B2 (en) 2011-07-10 2016-09-27 Guided Therapy Systems, Llc Systems and methods for accelerating healing of implanted material and/or native tissue
US8858471B2 (en) 2011-07-10 2014-10-14 Guided Therapy Systems, Llc Methods and systems for ultrasound treatment
US9011337B2 (en) 2011-07-11 2015-04-21 Guided Therapy Systems, Llc Systems and methods for monitoring and controlling ultrasound power output and stability
US9565870B2 (en) 2011-11-01 2017-02-14 Pepsico, Inc. Dispensing nozzle with an ultrasound activator
WO2013067041A1 (en) * 2011-11-01 2013-05-10 Indrani Deo Dispensing nozzle with an ultrasound activator
US9263663B2 (en) 2012-04-13 2016-02-16 Ardent Sound, Inc. Method of making thick film transducer arrays
US9802063B2 (en) 2012-09-21 2017-10-31 Guided Therapy Systems, Llc Reflective ultrasound technology for dermatological treatments
US9510802B2 (en) 2012-09-21 2016-12-06 Guided Therapy Systems, Llc Reflective ultrasound technology for dermatological treatments
CN103800955A (en) * 2012-11-09 2014-05-21 苏州工业园区职业技术学院 Ultrasonic wave trauma cleaning equipment
USD733319S1 (en) 2014-01-10 2015-06-30 Celleration, Inc. Ultrasonic treatment wand
USD733321S1 (en) 2014-01-10 2015-06-30 Celleration, Inc. Ultrasonic treatment device
US9744315B1 (en) * 2016-11-28 2017-08-29 Heat In A Click LLC Skin treatment apparatus

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