CN104027471B - The health food and its preparation technology of control blood sugar for human body and body weight - Google Patents
The health food and its preparation technology of control blood sugar for human body and body weight Download PDFInfo
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- CN104027471B CN104027471B CN201410073902.8A CN201410073902A CN104027471B CN 104027471 B CN104027471 B CN 104027471B CN 201410073902 A CN201410073902 A CN 201410073902A CN 104027471 B CN104027471 B CN 104027471B
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- 235000013402 health food Nutrition 0.000 title description 9
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Abstract
The invention provides the composition for controlling blood sugar for human body and/or body weight, it is prepared from by matrimony vine, Radix Glycyrrhizae, the Radix Astragali and balsam pear.In addition, application of preparation, preparation method and preparation of preparation present invention also offers said composition etc..
Description
Technical field
The invention belongs to medicine and field of health care food, specifically, the present invention relates to composition and health food (system
Agent), it is prepared from by matrimony vine, Radix Glycyrrhizae, the Radix Astragali and balsam pear, and for controlling blood sugar for human body and body weight, suitable long-term, high-dose makes
With.
Background technology
Matrimony vine, the also referred to as fruit of Chinese wolfberry, FRUCTUS LYCII, originate in the ground such as Tianjin, Henan, Hebei, Shanxi, Ningxia, are Solanaceae matrimony vines
Belong to the fruit of machaka.Contain 14 kinds of amino acid in matrimony vine, and containing compositions such as glycine betaine zeaxanthin, physalins,
With prolonging the effects such as declining anti-ageing.However, the property of medicine of matrimony vine it is sweet, warm, especially its warm effect it is quite strong, be not suitable for interior heat
Unclear, hypertension, catching a cold, having a fever, body has inflammation, the people of diarrhoea takes, even if Healthy People, long-term larger dose ground clothes
With, also easily there is humidifier fever, clinical symptoms include easily perspiration, can hair loss when serious.
Hyperglycaemia, high fat of blood and obesity etc. are lower caused " rich man's disease " modern life customs, there is presently no radical cure
Means are, it is necessary to Long-term taking medicine or take health food and control and improve.Therefore, the side effect of matrimony vine limit that it turns into can
It is taken with long-term, high-dose.
It is used to control blood sugar and body weight using Chinese medicine and matrimony vine compatibility, is also had been reported that in Chinese medicine and field of health care food,
As Chinese patent (application) 200810103671,200810114658,200810115255,200810116270,
201010166466th, 201110207274,201310223607 etc..But, this kind of Chinese medicine or health food are counted from ten at least
Taste raw material (crude drug), at most even select tens of taste raw material (crude drug), and formula is sufficiently complex, and the quality of production is difficult to control to.
The present inventor by long-term and arduous research, some fortune in addition, surprisingly, matrimony vine is with sweet
Grass, the Radix Astragali can cooperate with actions together with balsam pear compatibility, significantly improve the effect for controlling blood sugar and body weight, more it is imaginary not
To, after compatibility can also long-term, high-dose take, without there is side effect.The crude drug species of compatibility of the present invention is less,
Preparation technology is relatively simple, is easy to control product quality.In addition, the present inventors have additionally discovered that the formula directly oral taste is not
It is good, but also be not easy to be well mixed with seasoning, the deodorant tune such as malic acid, therefore investigated the production method of preparation.
The content of the invention
It is an object of the invention to provide new composition, it can be as medicine, it is also possible to used as health food, is used for
Control blood sugar for human body and body weight.In addition, present invention also offers being related to the preparation method of said composition, pharmaceutical preparation or health care to eat
Product and application etc..
Specifically, in a first aspect, the invention provides the composition for controlling blood sugar for human body and/or body weight, its
It is prepared from by matrimony vine, Radix Glycyrrhizae, the Radix Astragali and balsam pear.The composition of the first aspect of the present invention can be as medicine or pharmaceutical activity
Raw material, it is also possible to as health food or health raw-food material.So, composition of the invention can be pharmaceutical composition,
It can also be health-care food composition.
It is preferred that the composition of the first aspect of the present invention, it is carried by wolfberry fruit powder, licorice, Astragalus Root P.E and balsam pear
Thing is taken to mix.
It is preferred that in the composition of the first aspect of the present invention, wolfberry fruit powder is exactly the matrimony vine crushed, preferably it can cross 60 mesh
Sieve；Licorice is the water extract of Radix Glycyrrhizae, as described in specific embodiment；Astragalus Root P.E is the alcohol extract of the Radix Astragali, excellent
Choosing is ethanol extract, such as the extract of 95% (V/V) ethanol；Bitter Melon P.E is the non-water soluble substance of balsam pear, such as specific
Described in implementation method.
It is preferred that in the composition of the first aspect of the present invention, the weight ratio of matrimony vine, Radix Glycyrrhizae, the Radix Astragali and balsam pear for 350~
450: 72~92: 253~320: 255~323, preferably 360~440: 74~90: 258~314: 259~316, more preferably
380~420: 78~86: 272~300: 273~302, most preferably 400: 82: 286: 288.
It is also preferred that in the composition of the first aspect of the present invention, wolfberry fruit powder, licorice, Astragalus Root P.E and balsam pear
The weight ratio of extract is 350~450: 6.5~9.5: 48~63: 17~23, preferably 360~440: 7~9: 51~61: 18
~22, more preferably 380~420: 7.5~8.5: 53~59: 19~21, most preferably 400: 8: 56: 20.
In second aspect, the invention provides the preparation method of the composition of first aspect present invention, it includes,
(1) matrimony vine is crushed, wolfberry fruit powder is obtained；
(2) Radix Glycyrrhizae is extracted, licorice is obtained；
(3) Radix Astragali is extracted, Astragalus Root P.E is obtained；
(4) balsam pear is extracted, Bitter Melon P.E is obtained；With,
(5) mixing wolfberry fruit powder, licorice, Astragalus Root P.E and Bitter Melon P.E.
It is preferred that in the method for the second aspect of the present invention, it is to use water extraction extracting liquorice, such as specific embodiment to extract Radix Glycyrrhizae
Described；It is to use the alcohol extracting Radix Astragali to extract the Radix Astragali, is preferably extracted with ethanol, is such as extracted with 95% (V/V) ethanol；Extracting balsam pear is
Precipitation of the balsam pear in water is taken, as described in specific embodiment.
In the third aspect, the invention provides the preparation for controlling blood sugar for human body and/or body weight, it is pharmaceutical preparation,
Its composition for including first aspect present invention and pharmaceutically acceptable auxiliary material；In addition, present invention also offers for controlling
The preparation of blood sugar for human body and/or body weight, it is health food, and it includes and can be connect on the composition and food of first aspect present invention
The auxiliary material received.
It is preferred that the preparation of the composition of the first aspect of the present invention or the third aspect is long-term taking safety.Herein
In, refer to for a long time 3 weeks or more, preferably 4 weeks or more, such as 3 months.Herein, refer to safely except meeting state
Outside the security requirement of the medicine or food of Food and Drug Admistraton of family defined, what also no long-term taking matrimony vine was brought
Side effect, the side effect such as easily sweated and lose hair.The preparation of third aspect present invention is continuously taken with 10 grams/day of effective dose
With without discovery side effect.
Herein, term " pharmaceutically acceptable auxiliary material " includes pharmaceutically acceptable carrier, excipient, diluent
Deng they are compatible with active constituents of medicine.Pharmaceutical preparation is prepared to ordinary skill with pharmaceutically acceptable auxiliary material
It is known for personnel.Pharmaceutical preparation of the invention includes the composition of first aspect present invention as active component, by this
Composition and pharmaceutically acceptable assistant agent (carrier, excipient, diluent and tune as would be known to one of ordinary skill in the art
Taste agent etc.) combine, it is configured to various preparations, preferably solid pharmaceutical preparation and liquid preparation, such as tablet, pill, capsule (bag
Include sustained release or delay release releasing pattern), pulvis, supensoid agent, granule, tincture, syrup, emulsion agent, suspension, injection
Etc. formulation and various slow release formulations, so as to be adapted to various form of medication, for example orally, parenteral injection, mucous membrane, muscle, quiet
Arteries and veins is interior, subcutaneous, intraocular, intracutaneous or the form of medication by skin etc., most preferably orally.Particularly preferred auxiliary material includes dispersion
Agent, such as nanosizing dispersant, such as nano-starch, nanometer dextrin, Nano-meter SiO_22, Nano-meter CaCO33, nano-TiO2, nano zine oxide,
Nanometer indium, Nano Silver, nano-aluminum hydroxide, nano-sized iron oxide, nanometer iron chloride, nano-sized carbon, nanometer selenium, nano aluminium oxide, receive
Rice magnesia.Other suitable auxiliary materials include polyethylene glycols, PVP class water-solubility carrier, such as PEG2000-20000 or PVP
K15-K90 or PVA or PVP-PVA or CPD etc..
Herein, term " acceptable auxiliary material on food " includes acceptable carrier, excipient, dilution on food
Agent, flavor enhancement, colouring agent, fumet etc., they are compatible with health care of food active component.The composition of first aspect present invention can
In being directly added into food or raw-food material.
It is preferred that in the preparation of third aspect present invention, pharmaceutically or on food acceptable auxiliary material is malic acid, peppermint
One or more of brain, starch and dextrin.It is also preferred that the preparation of third aspect present invention is capsule or tablet.
The inventors discovered that, the seasoning such as malic acid, deodorant tune are not easy to mix with the composition of the first aspect of the present invention
Uniformly, therefore existing customary preparation methods have been abandoned, has first added the seasonings such as malic acid, deodorant tune to prepare.Therefore, the 4th
Aspect, the invention provides the preparation method of the preparation of third aspect present invention, it includes,
(1) matrimony vine is crushed, wolfberry fruit powder is obtained；
(2) Radix Glycyrrhizae is extracted, licorice is obtained；
(3) Radix Astragali is extracted, Astragalus Root P.E is obtained；
(4) balsam pear is extracted, Bitter Melon P.E is obtained；
(5) mixing licorice, malic acid and menthol, obtain mixture 1；
(6) blend mixture 1, Astragalus Root P.E and Bitter Melon P.E, obtain mixture 2；
(7) blend mixture 2, wolfberry fruit powder, starch and dextrin, obtain mixture 3；With,
(8) optionally mixture 3 is pelletized, whole grain and compressing tablet.
Wherein, the preferred embodiment of extraction may refer to the second aspect of the present invention.
At the 5th aspect, the composition the invention provides first aspect present invention is being prepared for controlling blood sugar for human body
And/or the application in the preparation of body weight.Wherein, the preparation can be pharmaceutical preparation, or health food, preferably described
Product is the preparation of third aspect present invention.
The beneficial effects of the present invention are, the same Radix Glycyrrhizae of matrimony vine, the Radix Astragali and balsam pear compatibility can with Collaborative Control blood sugar and body weight,
Effect significantly and can be taken with long-term safety, crude drug composition it is few and be easy to produce and quality control.
The present invention refer to existing open source literature, and these documents are their full text in order to more clearly describe the present invention
Content is included herein, just looks like that repeated description herein has been excessively for their full text.
In order to make it easy to understand, below will present invention is described by specific embodiment.It is important to note that
The description that these descriptions are merely exemplary, and be not meant to limit the scope of the invention.Using described in the embodiment of the present invention
Method, it is also possible to obtain present invention others technical scheme.According to the discussion of this specification, many changes of the invention, change
All it is obviously for one of ordinary skill in the art.
Specific embodiment
Plant material and chemical reagent in specific embodiment are the conventional material from market channel purchase.
The preparation of the laboratory sample of embodiment 1
(1) preparation of licorice：
500 milliliters of water are added to 100 grams of Glycyrrhiza Uralensis herbs crushed (being purchased from Beijing Tongrentang, Beijing, China)
After being decocted 1 hour in closed container, filtering retains filtrate, and filter residue adds 500 milliliters of water to be decocted in closed container 1 hour
Afterwards, filtering retains filtrate, and merging filtrate with 60 DEG C of dryings, obtains 9.8 grams of licorice, is named as G132.
(2) preparation of Astragalus Root P.E：
500 milliliter 95% (V/V) is added to 100 grams of Radix Astragali medicine materical crude slice crushed (being purchased from Beijing Tongrentang, Beijing, China)
After ethanol is decocted 0.5 hour in closed container, filtering retains filtrate, and filter residue adds 500 milliliter of 95% (V/V) ethanol closed
After being decocted 0.5 hour in container, filtering retains filtrate, and merging filtrate, with 45 DEG C of dryings (and reclaiming ethanol), obtains Astragalus Root P.E
19.6 grams.
(3) preparation of Bitter Melon P.E：
Take after 200 grams of fresh bitter is washed and cut into slices, remove flesh, after crushed, add 200 milliliters of water to be soaked 1 hour in 60 DEG C,
Retain filter residue after filtering and add 200 milliliters of water to be soaked 1 hour in 60 DEG C, retain filter residue with 60 DEG C of dryings, obtain Bitter Melon P.E
13.9 grams.
(4) preparation of wolfberry fruit powder
20g matrimony vines (being purchased from Beijing Tongrentang, Beijing, China) are taken, in 60 DEG C of dryings to water content between 12~13%
(w/w), crushed, pulverizer rotating speed 24000r/min with FW135 types pulverizer (being purchased from Tianjin Stettlen Instrument Ltd.),
Grinding time 30s.Wolfberry fruit powder cannot such as cross 80 mesh sieves by 100 mesh sieves, and the wolfberry fruit powder that discovery has about 80% cannot sieve, this
The possible origin cause of formation is that polyoses content is higher in matrimony vine, thus is not easy to crush, so as to influence production.Therefore taking wolfberry fruit powder crosses 60 mesh
Sieve, the wolfberry fruit powder for having more than 90% can sieve, and wolfberry fruit powder is thus obtained, and its particle diameter is not more than 60 mesh.
(5) preparation of CK1
Licorice, Astragalus Root P.E and the Bitter Melon P.E prepared according to said process are taken, 80 mesh were crushed respectively
Sieve, takes 8 grams of licorices, 56 grams of Astragalus Root P.Es and 20 grams of Bitter Melon P.Es of crushing, after being well mixed, obtains CK1.
(6) preparation of composition of the invention
The 84 grams of CK1 prepared according to said process are taken, is well mixed with 400 grams of wolfberry fruit powders prepared according to said process
Afterwards, obtain final product.
(7) preparation of preparation of the invention
Usual flavor enhancement and deodorant tune isoreactivity composition are added with the filler such as dextrin again after preparing, but the present inventor
It was found that malic acid and menthol are not easily separate uniformly, each taste is variant in causing the preparation for preparing, so improve preparing
Method is as follows：8 grams of licorices for taking crushing mix 20 minutes with 5 grams of malic acid and 1 gram of menthol, add the 56 of crushing
Gram Astragalus Root P.E and 20 grams of Bitter Melon P.Es mix 20 minutes, add 400 grams of wolfberry fruit powders, 335 grams of starch and 175 grams of dextrin
Mixing 20 minutes, adds 75% (V/V) ethanol to be made softwood, and 20 mesh sieves granulation, 60 DEG C of dryings, 18 mesh sieve whole grains, compressing tablet is pressed into
2000,0.5 gram/piece.
Short-term drug effect clinical observation of the embodiment 2 to hyperglycemia patient Postprandial glucose control.
The postprandial blood sugar of the diabetes B people of insulin insensitivity, is the important indicator of abnormal carbohydrate metabolism, therefore this implementation
Example is by investigating the blood sugar decreasing effect of medicine to the detection of such patient's postprandial blood sugar.According to state food drug administration
Clinical trial standard is performed, to the patient of random packet (age at 47-57 Sui, three one group of people, its fasting blood-glucose 7.5mM/L with
On, more than 10mM/L after the meal) wolfberry fruit powder, CK1 and composition of the invention that respectively prepared by oral administration embodiment 1, wherein Chinese holly
The dosage of Qi powder is 4 grams, and the dosage of CK1 is 0.85 gram, and the dosage of composition of the invention is 4.85 grams.On before lunch take medicine after
30 minutes, patient was taken food 300 grams of water boiled corns, and blood sugar is chemically examined after 2 hours, is compared with the blood sugar chemically examined before the meal is entered, as a result such as
Shown in lower Table I.
Result shows that CK1 and wolfberry fruit powder have certain control action to blood sugar patient's postprandial blood sugar high, although having been reported that
The extract such as the Radix Astragali and balsam pear play the role of it is hypoglycemic, but control effect only has 10-15%, this is probably due to dose
It is less and cannot work；Composition of the invention then has the control action of highly significant, effect to blood sugar patient's postprandial blood sugar high
Exclusive use CK1 and wolfberry fruit powder are much better than, show that CK1 and wolfberry fruit powder have synergistic function.
Table I medication/nonuser front/rear blood sugar of meal compares
According to the reflection of patient, it is unattractive directly to take composition mouthfeel of the invention, easily causes clothes for patients use
It is intermittent, be unfavorable for that fixation is taken daily, and preparation mouthfeel of the invention is good, and the medication enthusiasm of patient is significantly improved,
Therefore preparation of the invention is used instead in long-term experiment.
Long term effect clinical observation of the embodiment 3 to blood sugar and body weight
Clinical trial standard according to state food drug administration is performed, and to the random patient being grouped, (age is in 47-57
Year, three one group of people, its fasting bloodSugared more than 7.5mM/L, after the meal more than 10mM/L) oral administration embodiment 1 respectivelyThe Chinese holly of preparation
Qi powder, CK1 and preparation of the invention, the wherein dosage of wolfberry fruit powder are 4 grams, and the dosage of CK1 is 0.85 gram, preparation of the invention
Dosage is 10 grams, surrounding is carried out altogether before daily breakfast once.After four weeks before blood test fasting blood-glucose and body weight, with medication
Fasting blood-glucose and body weight are made comparisons, as a result shown in following Table II.
Result shows, CK1 and the independent long-term use of wolfberry fruit powder, and hypoglycemic ratio only has 8%, 1-2 kilograms of weight loss, entirely
Face is worse than using preparation of the invention, and especially in long-term hypoglycemic ratio, preparation of the invention has obvious synergy.
In addition to the difference in curative effect, even more noteworthy, at the end of experiment, using wolfberry fruit powder, there are two patients to occur easy
The phenomenon sweated, more has 1 patient the side effect for losing hair occur, and other two groups of patient has not reported side effect.
But, the preparation of the invention of same period observation does not significantly increase the effect of effect, therefore system of the invention to control blood fat
Agent is mainly used in controlling blood sugar and body weight.
The comparing of fasting blood-glucose and body weight before and after Table II long-term prescription
Claims (13)
1. it is used to control the composition of blood sugar for human body and/or body weight, it is carried by the ethanol of wolfberry fruit powder, the water extract of Radix Glycyrrhizae, the Radix Astragali
The non-water soluble substance of thing and balsam pear is mixed, wherein, wolfberry fruit powder, the water extract of Radix Glycyrrhizae, the ethanol extract of the Radix Astragali and balsam pear
Non-water soluble substance weight ratio be 350~450: 6.5~9.5: 48~63: 17~23.
2. the composition described in claim 1, wherein wolfberry fruit powder, the water extract of Radix Glycyrrhizae, the ethanol extract of the Radix Astragali and balsam pear is non-
The weight ratio of water-soluble substances is 360~440: 7~9: 51~61: 18~22.
3. the composition described in claim 2, wherein, wolfberry fruit powder, the water extract of Radix Glycyrrhizae, the ethanol extract of the Radix Astragali and balsam pear it is non-
The weight ratio of water-soluble substances is 380~420: 7.5~8.5: 53~59: 19~21.
4. the composition described in claim 3, wherein, wolfberry fruit powder, the water extract of Radix Glycyrrhizae, the ethanol extract of the Radix Astragali and balsam pear it is non-
The weight ratio of water-soluble substances is 400: 8: 56: 20.
5. the composition described in claim 1, wherein, wolfberry fruit powder is the matrimony vine of the crushing that can cross 60 mesh sieves.
6. the composition described in claim 1, wherein, the ethanol extract of the Radix Astragali is the extract of 95% (V/V) ethanol of the Radix Astragali.
7. the preparation method of any described composition of claim 1~6, it includes,
(1) matrimony vine is crushed, wolfberry fruit powder is obtained；
(2) water extraction extracting liquorice is used, licorice is obtained；
(3) Radix Astragali is extracted with ethanol, obtains Astragalus Root P.E；
(4) precipitation of the balsam pear in water is taken, Bitter Melon P.E is obtained；With,
(5) mixing wolfberry fruit powder, licorice, Astragalus Root P.E and Bitter Melon P.E.
8. be used to control the preparation of blood sugar for human body and/or body weight, it include any described composition of claim 1~6 and
Acceptable auxiliary material pharmaceutically or on food.
9. the preparation described in claim 8, wherein pharmaceutically or on food acceptable auxiliary material is malic acid, menthol, starch
With one or more of dextrin.
10. the preparation described in claim 8, it is capsule or tablet.
The preparation method of any described preparation of 11. claim 8-10, it includes,
(1) matrimony vine is crushed, wolfberry fruit powder is obtained；
(2) water extraction extracting liquorice is used, licorice is obtained；
(3) Radix Astragali is extracted with ethanol, obtains Astragalus Root P.E；
(4) precipitation of the balsam pear in water is taken, Bitter Melon P.E is obtained；
(5) mixing licorice, malic acid and menthol, obtain mixture 1；
(6) blend mixture 1, Astragalus Root P.E and Bitter Melon P.E, obtain mixture 2；
(7) blend mixture 2, wolfberry fruit powder, starch and dextrin, obtain mixture 3；With,
(8) optionally mixture 3 is pelletized, whole grain and compressing tablet.
Any described composition of 12. claim 1-6 is in the preparation for controlling blood sugar for human body and/or body weight is prepared
Using.
Application described in 13. claims 12, wherein preparation are any described preparations of claim 8~10.
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| 苦芪降糖胶囊对实验性糖尿病的影响;崔泽等;《中国医院药学杂志》;20100430;第30卷(第8期);第707页左栏"讨论"部分 * |
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