CN103998065A - 在柠檬酸盐缓冲液中的18F-Fluciclovine组合物 - Google Patents

在柠檬酸盐缓冲液中的18F-Fluciclovine组合物 Download PDF

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Publication number
CN103998065A
CN103998065A CN201280063530.XA CN201280063530A CN103998065A CN 103998065 A CN103998065 A CN 103998065A CN 201280063530 A CN201280063530 A CN 201280063530A CN 103998065 A CN103998065 A CN 103998065A
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CN
China
Prior art keywords
pharmaceutical composition
formula
compound
facbc
described compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201280063530.XA
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English (en)
Chinese (zh)
Inventor
K.罗莫伦
O.赖恩
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GE Healthcare Ltd
Original Assignee
GE Healthcare Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/EP2011/073670 external-priority patent/WO2012089594A1/en
Application filed by GE Healthcare Ltd filed Critical GE Healthcare Ltd
Priority to CN201811258984.8A priority Critical patent/CN109966515A/zh
Publication of CN103998065A publication Critical patent/CN103998065A/zh
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0404—Lipids, e.g. triglycerides; Polycationic carriers
    • A61K51/0406—Amines, polyamines, e.g. spermine, spermidine, amino acids, (bis)guanidines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
CN201280063530.XA 2011-12-21 2012-12-21 在柠檬酸盐缓冲液中的18F-Fluciclovine组合物 Pending CN103998065A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201811258984.8A CN109966515A (zh) 2011-12-21 2012-12-21 在柠檬酸盐缓冲液中的18F-Fluciclovine组合物

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EPPCT/EP2011/073670 2011-12-21
PCT/EP2011/073670 WO2012089594A1 (en) 2010-12-29 2011-12-21 Eluent solution
PCT/EP2012/076689 WO2013093025A1 (en) 2011-12-21 2012-12-21 18f - fluciclovine compositions in citrate buffers

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201811258984.8A Division CN109966515A (zh) 2011-12-21 2012-12-21 在柠檬酸盐缓冲液中的18F-Fluciclovine组合物

Publications (1)

Publication Number Publication Date
CN103998065A true CN103998065A (zh) 2014-08-20

Family

ID=47436002

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201280063530.XA Pending CN103998065A (zh) 2011-12-21 2012-12-21 在柠檬酸盐缓冲液中的18F-Fluciclovine组合物
CN201811258984.8A Pending CN109966515A (zh) 2011-12-21 2012-12-21 在柠檬酸盐缓冲液中的18F-Fluciclovine组合物

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201811258984.8A Pending CN109966515A (zh) 2011-12-21 2012-12-21 在柠檬酸盐缓冲液中的18F-Fluciclovine组合物

Country Status (15)

Country Link
US (1) US20150231249A1 (cg-RX-API-DMAC10.html)
EP (1) EP2793954B1 (cg-RX-API-DMAC10.html)
JP (1) JP6446268B2 (cg-RX-API-DMAC10.html)
KR (1) KR20140102700A (cg-RX-API-DMAC10.html)
CN (2) CN103998065A (cg-RX-API-DMAC10.html)
AU (1) AU2012356846B2 (cg-RX-API-DMAC10.html)
CA (1) CA2853415C (cg-RX-API-DMAC10.html)
ES (1) ES2841109T3 (cg-RX-API-DMAC10.html)
GB (1) GB2509476B (cg-RX-API-DMAC10.html)
IL (1) IL232397A (cg-RX-API-DMAC10.html)
IN (1) IN2014DN03245A (cg-RX-API-DMAC10.html)
PL (1) PL2793954T3 (cg-RX-API-DMAC10.html)
RU (1) RU2623163C2 (cg-RX-API-DMAC10.html)
SG (1) SG11201403412YA (cg-RX-API-DMAC10.html)
WO (1) WO2013093025A1 (cg-RX-API-DMAC10.html)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115484992A (zh) * 2020-04-09 2022-12-16 蓝地诊断有限公司 药物制剂

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11534494B2 (en) 2011-12-21 2022-12-27 Ge Healthcare Limited Formulation and method of synthesis
GB201411569D0 (en) 2014-06-30 2014-08-13 Ge Healthcare Ltd Novel formulation and method of synthesis
GB201305687D0 (en) * 2013-03-28 2013-05-15 Ge Healthcare Ltd Radiolabelling process

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1646175A (zh) * 2002-04-24 2005-07-27 马林克罗特公司 获得2－18f－氟－2－脱氧－d－葡萄糖(18f－fdg)溶液的方法
CN101636183A (zh) * 2007-02-13 2010-01-27 日本医事物理股份有限公司 放射性诊断显像剂的制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7993626B2 (en) * 2007-01-11 2011-08-09 Immunomedics, Inc. Methods and compositions for F-18 labeling of proteins, peptides and other molecules
DE60236971D1 (de) 2002-11-05 2010-08-19 Ion Beam Applic Sa Stabilisierung von wässerigen zusammensetzungen von 18f-markiertem 2-fluoro-2-deoxy-d-glukose mit ethanol
SG144160A1 (en) * 2003-07-24 2008-07-29 Bracco Imaging Spa Stable radiopharmaceutical compositions and methods for their preparation
GB0422004D0 (en) * 2004-10-05 2004-11-03 Amersham Plc Method of deprotection
PL1978015T3 (pl) * 2005-11-29 2018-07-31 Nihon Medi-Physics Co., Ltd. Związek prekursorowy związku organicznego znakowanego radioaktywnym halogenem
EP2017258B1 (en) * 2006-05-11 2012-03-14 Nihon Medi-Physics Co., Ltd. Process for production of radioactive fluorine-labeled organic compound
WO2008056481A1 (en) 2006-11-09 2008-05-15 Nihon Medi-Physics Co., Ltd. Radioactive diagnostic imaging agent
PL2106808T3 (pl) * 2006-12-21 2018-07-31 Nihon Medi-Physics Co., Ltd. Promieniotwórczy znacznik do obrazowania diagnostycznego zawierający kwas 1-amino-3-[18F]fluorocyklobutanokarboksylowy
CN108218650A (zh) * 2010-12-29 2018-06-29 通用电气健康护理有限公司 洗脱溶液

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1646175A (zh) * 2002-04-24 2005-07-27 马林克罗特公司 获得2－18f－氟－2－脱氧－d－葡萄糖(18f－fdg)溶液的方法
CN101636183A (zh) * 2007-02-13 2010-01-27 日本医事物理股份有限公司 放射性诊断显像剂的制备方法

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115484992A (zh) * 2020-04-09 2022-12-16 蓝地诊断有限公司 药物制剂
CN115484992B (zh) * 2020-04-09 2026-01-02 蓝地诊断有限公司 药物制剂

Also Published As

Publication number Publication date
CN109966515A (zh) 2019-07-05
IN2014DN03245A (cg-RX-API-DMAC10.html) 2015-07-10
PL2793954T3 (pl) 2021-04-06
AU2012356846B2 (en) 2017-07-27
AU2012356846A1 (en) 2014-06-05
RU2014118755A (ru) 2016-02-10
ES2841109T3 (es) 2021-07-07
RU2623163C2 (ru) 2017-06-22
JP2015500865A (ja) 2015-01-08
JP6446268B2 (ja) 2018-12-26
US20150231249A1 (en) 2015-08-20
GB2509476B (en) 2018-08-08
GB201408239D0 (en) 2014-06-25
CA2853415C (en) 2020-11-17
CA2853415A1 (en) 2013-06-27
IL232397A (en) 2016-12-29
IL232397A0 (en) 2014-06-30
EP2793954A1 (en) 2014-10-29
WO2013093025A1 (en) 2013-06-27
EP2793954B1 (en) 2020-10-21
GB2509476A (en) 2014-07-02
KR20140102700A (ko) 2014-08-22
SG11201403412YA (en) 2014-07-30

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