CN103992945B - A kind of constant-temperature incubation hybrid device - Google Patents
A kind of constant-temperature incubation hybrid device Download PDFInfo
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- CN103992945B CN103992945B CN201410211447.3A CN201410211447A CN103992945B CN 103992945 B CN103992945 B CN 103992945B CN 201410211447 A CN201410211447 A CN 201410211447A CN 103992945 B CN103992945 B CN 103992945B
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- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/12—Means for regulation, monitoring, measurement or control, e.g. flow regulation of temperature
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Abstract
The invention discloses a kind of constant-temperature incubation hybrid device, comprise reaction chamber and test tube bracket, the inside of described reaction chamber is divided into cooling air air-inlet cavity, cooling air return air chamber, hot air cavity and four, main reaction chamber cavity portion by the dividing plate in vertical vertical plane direction; In hot air cavity, be provided with well heater and fan, the wall bottom shared at main reactor and hot air cavity is provided with hot-air mouth; Test tube support frame is arranged in main reaction chamber, and test tube bracket is connected with mixing motor by turning axle, regulates test tube bracket reciprocally swinging by mixing motor.The top temperature of product of the present invention can reach 99.9 DEG C, and be not only the modification of magnetic nanoparticle and hybridization and provide suitable and temperature widely, and temperature control is accurate, effective mechanical movement ensure that nano particle fully mixes in the solution.Physical construction is simply compact, and flexible operation is controlled, can realize the process of molecular hybridization automatically.
Description
Technical field
The present invention relates to a kind of constant-temperature incubation hybrid device, particularly relate to the micro-volume molecular hybridization device that micro-and nano-particles is modified, belong to biological material analysis quasi-instrument and molecular hybridization.
Background technology
Molecular hybridization has the specificity of very high sensitivity and height, in biology field, and the aspect such as the detection of specific gene and medical diagnosis on disease in the screening of the widespread use of this technology and clone gene, the making of restriction enzyme mapping, genome.Nano particle is most study in biomedicine, most widely used nano material, and magnetic nano-particle to have specific surface area large, superparamagnetism, in the solution good dispersity, be easy to wash-out and absorption, and the character of many uniquenesses such as surface chemical modification is easy.Thus all respects such as external visual detection of pathogen detection, tumor markers early diagnosis, disease are widely used in.
By nano particle application and biomedical sector, must solve chemistry and biomacromolecule in the modification problem of nano grain surface, these biomacromolecules comprise protein, carbohydrate, nucleic acid probe etc.Utilize the effect of other biomolecules of these biomacromolecules and its specific recognition of modifying, play the function identifying this quasi-molecule.Due to the singularity of Bioexperiment, the chemical reaction of nano grain surface needs certain temperature; Temperature affects the important influence factor of molecular hybridization process one, and temperature is too high or too low, can be all that biomacromolecule itself loses activity function; And biomacromolecule can be affected as antigen-antibody, the crossbreeding effect of nucleic acid molecule.Therefore, nano-particle modified molecular hybridization needs to carry out in the accurate environment of temperature control.
At present, at the Hybridization Oven/stove of the marketization, it is the molecular hybridization based on traditional way.By probe modification on solid substrate as gene chip or Hybond membrane, the molecular hybridization process of traditional way is loaded down with trivial details, not easy cleaning be separated, the volume of hybridization solution is comparatively large, mainly carries out in the tens hybridization bottles to hundreds of milliliter.Be different from above-mentioned hybridization conditions, the volume of the reaction solution of nanometer-material-modified micro-volume hybridization is within 1000 μ L, and reaction vessel mostly is the centrifuge tube of 200 μ L ~ 1500 μ L.But, be not applicable to the special purpose device of nano-particle modified micro-volume molecular hybridization on the market.Magnetic nano-particle is free settling in the solution, simultaneously due to the surface effects of nano particle, make nano particle occur agglomeration in the solution, not only change the performance of biomolecules, and uneven owing to mixing, have a strong impact on the modification of nano particle and the efficiency of molecular hybridization.
Summary of the invention
Goal of the invention: in order to overcome the deficiencies in the prior art, the invention provides a kind of portable constant-temperature incubation hybrid device, accurate temperature can not only be provided for the modification of nanoparticle and crossover process, and can be rotated by turning axle discontinuity, solution is mixed fully.
Technical scheme: for achieving the above object, the technical solution used in the present invention is:
A kind of constant-temperature incubation hybrid device, comprise reaction chamber and test tube bracket, the inside of described reaction chamber is divided into cooling air air-inlet cavity, cooling air return air chamber, hot air cavity and four, main reaction chamber cavity portion by the dividing plate in vertical vertical plane direction; In hot air cavity, be provided with well heater and fan, the wall bottom shared at main reactor and hot air cavity is provided with hot-air mouth; Test tube support frame is arranged in main reaction chamber, and test tube bracket is connected with mixing motor by turning axle, regulates test tube bracket reciprocally swinging by mixing motor;
Top in reaction chamber, be provided with the sealing bucket in vertical vertical plane direction, the sidewall of sealing bucket chooses four buses, in the direction of the clock, the wall that first bus and main reactor and hot air cavity share is tightly connected, the wall that second bus and hot air cavity and cooling air return air chamber share is tightly connected, the wall that triple bus-bar and cooling air return air chamber and cooling air air-inlet cavity share is tightly connected, the wall that 4th bus and cooling air air-inlet cavity and main reaction chamber share is tightly connected, on the sidewall of sealing bucket, corresponding each cavity portion is provided with a wind-tunnel be communicated with,
Sealing bucket internal vertical vertical plane direction is provided with wind direction baffle plate, wind direction baffle plate is connected with wind direction motor by rotary valve, the angle of wind direction baffle plate is regulated: when heating, hot air cavity is communicated with main reaction chamber, and cooling air air-inlet cavity is communicated with cooling air return air chamber by wind direction motor; During cooling, hot air cavity is communicated with cooling air return air chamber, and cooling air air-inlet cavity is communicated with main reaction chamber.
By controlling well heater, the heat source temperature produced in hot air cavity can be regulated, by controlling fan and wind direction baffle plate, thermal source can be regulated to enter the intensity in main reaction chamber, finally reach the control to main reaction cavity temperature.By controlling the mode of operation of mixing motor, the course of action of test tube bracket can be regulated, finally making the centrifuge tube be placed on test tube bracket produce corresponding sports, realizing the objects such as mixing; The rotation that mixing motor does discontinuity is generally set, by the gravity and shearing force changing the nano particle of micro-volume, solution is fully mixed.Test tube bracket is installed on the rotary shaft in detachable adjustable mode, can regulate the angle of test tube bracket, preferably angle and rotating speed is selected according to different liquor capacities, and then produce different shearing forces, the micro-volume Dynamic Crossover that the magnetic nano-particle that the present invention is applicable to 10 ~ 1000 μ L is modified.
Preferably, wind direction baffle plate is provided with one group of limit sensors, is controlled the angle of rotation of wind direction baffle plate by limit sensors.
When heating main reaction chamber, by limit sensors and wind direction electric machine control wind direction baffle plate to heated condition position, fan and well heater are started working, and are realized the heat-processed in main reaction chamber by internal air circulation; When lowering the temperature to main reaction cavity, by limit sensors and wind direction electric machine control wind direction baffle plate to state of cooling position, well heater quits work, and the warm air in reaction chamber is discharged, outside air flows in reaction chamber, is realized the process of cooling in main reaction chamber by air inner-outer circulation.
Preferably, in main reaction chamber, be provided with temperature sensor, the temperature in main reaction chamber is monitored in real time, feed back to controller and carry out feedback control, be convenient to realize thermostatic control.
Preferably, also comprise control chamber, described control chamber and reaction chamber are all arranged in cabinet shell; In control chamber, be provided with controller, in described controller, be provided with temperature-control circuit and motor-drive circuit; The input signal of temperature-control circuit comprises design temperature in main reaction chamber and actual temperature, and the output signal of temperature-control circuit comprises the control signal of well heater, fan and wind direction motor; The input signal of described motor-drive circuit comprises mixing requirement, and the output signal of motor-drive circuit comprises the control signal of mixing motor.
Preferably, the outer wall of described control chamber is provided with touch control screen, the design temperature in main reaction chamber and mixing require to input in controller by touch control screen, simultaneously can hatch status information in crossover process by Real-time Feedback, simple and convenient.
Preferably, described main reaction chamber is provided with double thermal insulation glass door, so that observe the state in main reaction chamber at any time and reach good effect of heat insulation.
Preferably, in described cooling air air-inlet cavity and cooling air return air chamber all by subregion plate two portions; Subregion plate in cooling air air-inlet cavity is provided with the second cooling air blast inlet, cooling air air-inlet cavity outer wall is provided with the first cooling air blast inlet be communicated with extraneous air; Subregion plate in cooling air return air chamber is provided with the first cold return air inlet, cooling air return air cavity outer wall is provided with the second cooling air return air inlet be communicated with extraneous air; For the ease of accelerating heat radiation, can heat abstractor be set.
Preferably, described test tube bracket is the structure of two panels semi-disc, and semi-disc is provided with the round hole that can insert different size centrifuge tube.
Beneficial effect: constant-temperature incubation hybrid device provided by the invention, there is following advantage: 1, for the modification of nano material and molecular hybridization provide the accurately temperature be suitable for, prevent the change of biomacromolecule character and improve hybridization precision, reagent has been saved in micro-volume hybridization, reduces cost; 2, the discontinuity of test tube bracket rotates, and not only makes micro-volume solution gravity be changed, and solution and nanoparticle is better mixed due to the effect of shearing force, ensure that fully contacting of reagent in solution and nanoparticle; Test tube bracket adjustable angle is also easy to change, and can change the test tube bracket of different size according to different demands; 3, compared with same device, compact construction, more miniaturization; 4, the present invention has filled up the blank that market is applicable to the constant-temperature incubation hybrid device of micro-volume.
Accompanying drawing explanation
Fig. 1 is the surface structure schematic diagram of constant-temperature incubation hybrid device of the present invention;
Fig. 2 is side-view of the present invention;
Fig. 3,4 is internal structure schematic diagram of the present invention.
Embodiment
Below in conjunction with accompanying drawing, the present invention is further described.
Fig. 3 and Figure 4 shows that a kind of constant-temperature incubation hybrid device as shown in Figure 1, Figure 2, comprises cabinet shell 1, is provided with control chamber 3 and reaction chamber 2 in cabinet shell 1, the gap filling with insulation material between cabinet shell 1 and reaction chamber 2.
The inside of described reaction chamber 2 is divided into cooling air air-inlet cavity, cooling air return air chamber, hot air cavity and four, main reaction chamber cavity portion by the dividing plate 21 in vertical vertical plane direction; In hot air cavity, be provided with well heater 18 and fan 17, the wall bottom shared at main reactor and hot air cavity is provided with hot-air mouth 22; Test tube bracket 7 is arranged in main reaction chamber, and in main reaction chamber, be also provided with two temperature sensors, two temperature sensors are designated as the first temperature sensor 13 and the second temperature sensor 14 respectively simultaneously; Test tube bracket 7 is connected with mixing motor 15 by turning axle 8, regulates test tube bracket 7 reciprocally swinging, be specially: vertical rotating shaft 8 is installed with central shaft 10 by mixing motor 15, and test tube bracket 7 is fixing on the center shaft 10 by screw 9; Described test tube bracket 7 is the structure of two panels semi-disc, and semi-disc is provided with the round hole that can insert 200 μ L, 500 μ L, 1500 μ L centrifuge tubes 22; Described main reaction chamber is provided with double thermal insulation glass door 5, and operator can open double thermal insulation glass door 5 and be arranged in main reaction chamber by test tube bracket 7; Mixing motor 15 is arranged on mixing motor cabinet 11.
Top in reaction chamber, be provided with the sealing bucket in vertical vertical plane direction, the sidewall of sealing bucket chooses four buses, in the direction of the clock, the wall that first bus and main reactor and hot air cavity share is tightly connected, the wall that second bus and hot air cavity and cooling air return air chamber share is tightly connected, the wall that triple bus-bar and cooling air return air chamber and cooling air air-inlet cavity share is tightly connected, the wall that 4th bus and cooling air air-inlet cavity and main reaction chamber share is tightly connected, on the sidewall of sealing bucket, corresponding each cavity portion is provided with a wind-tunnel be communicated with, all by subregion plate two portions in described cooling air air-inlet cavity and cooling air return air chamber, subregion plate in cooling air air-inlet cavity is provided with the second cooling air blast inlet 28, cooling air air-inlet cavity outer wall is provided with the first cooling air blast inlet 19 be communicated with extraneous air, subregion plate in cooling air return air chamber is provided with the first cold return air inlet 27, cooling air return air cavity outer wall is provided with the second cooling air return air inlet 20 be communicated with extraneous air.
Sealing bucket internal vertical vertical plane direction is provided with wind direction baffle plate 6, wind direction baffle plate 6 is connected with wind direction motor 16 by rotary valve, wind direction motor 16 is arranged on wind direction motor cabinet 12, the angle of wind direction baffle plate 6 is regulated: when heating by wind direction motor 16 and limit sensors, hot air cavity is communicated with the second wind-tunnel 23 by the first wind-tunnel 24 with main reaction chamber, and cooling air air-inlet cavity is communicated with the 4th wind-tunnel 25 by the 3rd wind-tunnel 26 with cooling air return air chamber; During cooling, hot air cavity is communicated with the 3rd wind-tunnel 26 by the second wind-tunnel 23 with cooling air return air chamber, and cooling air air-inlet cavity is communicated with the first wind-tunnel 24 by the 4th wind-tunnel 25 with main reaction chamber.
In control chamber 3, be provided with controller, in described controller, be provided with temperature-control circuit and motor-drive circuit; The input signal of temperature-control circuit comprises design temperature in main reaction chamber and actual temperature (temperature sensor provides), and the output signal of temperature-control circuit comprises the control signal of well heater 18, fan 17 and wind direction motor 16; The input signal of described motor-drive circuit comprises mixing requirement, and the output signal of motor-drive circuit comprises the control signal of mixing motor 15; The outer wall of described control chamber 3 is provided with touch control screen 4, the design temperature in main reaction chamber and mixing require to be inputed in controller by touch control screen 4.
Use the constant-temperature incubation hybrid device of this case to carry out constant-temperature incubation, specific implementation process is as follows:
To be equipped with in round hole that the centrifuge tube 22 preparing reagent inserts on test tube bracket 7, after power supply is connected, the optimum configurations of temperature and mixing requirement is carried out by touch control screen 4, the scope that arranges of rotating speed is at 0 ~ 60rpm, and realize the real-time display of temperature and experiment process, the temperature of two temperature sensor collections sends temperature-control circuit to, and temperature-control circuit carries out corresponding operation according to actual temperature to the contrast of design temperature.When actual temperature is lower than design temperature, main reaction chamber is heated, wind direction baffle plate 6 angle of rotation is controlled by limit sensors and wind direction motor 16, wind direction baffle plate 6 is made to be in horizontality, well heater 18 heats, fan 17 is started working, warm air in hot air cavity is by the second wind-tunnel 23, first wind-tunnel 24 enters main reaction chamber, air in main reaction chamber enters hot air cavity by hot-air mouth 22, main reaction chamber and hot air cavity is made to carry out inner air flowing, accelerate heat-up rate, ensure that the homogeneity of reaction chamber 2 internal temperature, and realize the control of constant temperature, mixing motor 15 controls the rotating speed of test tube bracket 7 and turns to, by the periodicity of test tube bracket 7 and the rotation of discontinuity, the liquid in centrifuge tube 22 is made constantly to change the flow direction due to the change of gravity and shearing force, thus reach the effect that nanoparticle and hybridization solution fully mix, and then realize molecular hybridization.When lowering the temperature to reaction chamber 2 after hybridization completes, wind direction baffle plate 6 is in plumbness, well heater 18 stops heating, warm air in reaction chamber 2 discharges reaction chamber 2 through hot-air mouth 22, second wind-tunnel 23, the 3rd wind-tunnel 26 and the first cold return air inlet 27, second cooling air return air inlet 20, extraneous air is by the first cooling air blast inlet 19, second cooling air blast inlet 28, enter in reaction chamber 2 through the 4th wind-tunnel 25, first wind-tunnel 24, by air outside circulation, temperature in reaction chamber 2 is reduced fast.
The top temperature of this case product can reach 99.9 DEG C, and be not only the modification of magnetic nanoparticle and hybridization and provide suitable and temperature widely, and temperature control is accurate, effective mechanical movement ensure that nano particle fully mixes in the solution.Physical construction is simply compact, and flexible operation is controlled, can realize the process of molecular hybridization automatically.
The above is only the preferred embodiment of the present invention; be noted that for those skilled in the art; under the premise without departing from the principles of the invention, can also make some improvements and modifications, these improvements and modifications also should be considered as protection scope of the present invention.
Claims (6)
1. a constant-temperature incubation hybrid device, comprises reaction chamber and test tube bracket, it is characterized in that: the inside of described reaction chamber is divided into cooling air air-inlet cavity, cooling air return air chamber, hot air cavity and four, main reaction chamber cavity portion by the dividing plate in vertical vertical plane direction; In hot air cavity, be provided with well heater and fan, the wall bottom shared at main reactor and hot air cavity is provided with hot-air mouth; Test tube support frame is arranged in main reaction chamber, and test tube bracket is connected with mixing motor by turning axle, regulates test tube bracket reciprocally swinging by mixing motor;
Top in reaction chamber, be provided with the sealing bucket in vertical vertical plane direction, the sidewall of sealing bucket chooses four buses, in the direction of the clock, the wall that first bus and main reactor and hot air cavity share is tightly connected, the wall that second bus and hot air cavity and cooling air return air chamber share is tightly connected, the wall that triple bus-bar and cooling air return air chamber and cooling air air-inlet cavity share is tightly connected, the wall that 4th bus and cooling air air-inlet cavity and main reaction chamber share is tightly connected, on the sidewall of sealing bucket, corresponding each cavity portion is provided with a wind-tunnel be communicated with,
Sealing bucket internal vertical vertical plane direction is provided with wind direction baffle plate, wind direction baffle plate is connected with wind direction motor by rotary valve, the angle of wind direction baffle plate is regulated: when heating, hot air cavity is communicated with main reaction chamber, and cooling air air-inlet cavity is communicated with cooling air return air chamber by wind direction motor; During cooling, hot air cavity is communicated with cooling air return air chamber, and cooling air air-inlet cavity is communicated with main reaction chamber; Wind direction baffle plate is provided with one group of limit sensors, is controlled the angle of rotation of wind direction baffle plate by limit sensors.
2. constant-temperature incubation hybrid device according to claim 1, is characterized in that: in main reaction chamber, be provided with temperature sensor.
3. constant-temperature incubation hybrid device according to claim 1, is characterized in that: also comprise control chamber, and described control chamber and reaction chamber are all arranged in cabinet shell; In control chamber, be provided with controller, in described controller, be provided with temperature-control circuit and motor-drive circuit; The input signal of temperature-control circuit comprises design temperature in main reaction chamber and actual temperature, and the output signal of temperature-control circuit comprises the control signal of well heater, fan and wind direction motor; The input signal of described motor-drive circuit comprises mixing requirement, and the output signal of motor-drive circuit comprises the control signal of mixing motor.
4. constant-temperature incubation hybrid device according to claim 3, is characterized in that: the outer wall of described control chamber is provided with touch control screen, and the design temperature in main reaction chamber and mixing require to be inputed in controller by touch control screen.
5. constant-temperature incubation hybrid device according to claim 1, is characterized in that: described main reaction chamber is provided with double thermal insulation glass door.
6. constant-temperature incubation hybrid device according to claim 1, is characterized in that: described test tube bracket is the structure of two panels semi-disc, and semi-disc is provided with the round hole that can insert different size centrifuge tube.
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| CN201410211447.3A CN103992945B (en) | 2014-05-19 | 2014-05-19 | A kind of constant-temperature incubation hybrid device |
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| CN201410211447.3A CN103992945B (en) | 2014-05-19 | 2014-05-19 | A kind of constant-temperature incubation hybrid device |
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| CN103992945B true CN103992945B (en) | 2015-09-23 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023122296A1 (en) * | 2021-12-22 | 2023-06-29 | Somalogic Operating Co., Inc. | Method for conducting uniform reactions |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108889455A (en) * | 2018-06-22 | 2018-11-27 | 黄媛容 | A kind of orthopaedics control laboratory constant temperature centrifugal device |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| JPH09234226A (en) * | 1996-02-29 | 1997-09-09 | Atom Medical Kk | Incubator |
| US6482615B2 (en) * | 2001-03-02 | 2002-11-19 | Integrated Genetic Devices Ltd. | Method and apparatus for effecting rapid thermal cycling of samples in microtiter plate size |
| CN2789267Y (en) * | 2005-03-22 | 2006-06-21 | 肖先进 | Molecular hybridization instrument |
| CN101748046B (en) * | 2009-12-14 | 2012-08-15 | 东南大学 | Full temperature micro volume blending incubation and hybridization instrument |
| CN101858906B (en) * | 2010-04-29 | 2014-01-15 | 东南大学 | Total air temperature liquid-phase particle incubation and hybridization device with vibration function |
| CN202808804U (en) * | 2012-10-25 | 2013-03-20 | 杭州奥盛仪器有限公司 | Humidifying temperature-controlling oscillatory type hybridization device |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023122296A1 (en) * | 2021-12-22 | 2023-06-29 | Somalogic Operating Co., Inc. | Method for conducting uniform reactions |
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