CN103992627A - Environment-friendly bio-based polymer hemodialyzer casing material - Google Patents
Environment-friendly bio-based polymer hemodialyzer casing material Download PDFInfo
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- CN103992627A CN103992627A CN201410212639.6A CN201410212639A CN103992627A CN 103992627 A CN103992627 A CN 103992627A CN 201410212639 A CN201410212639 A CN 201410212639A CN 103992627 A CN103992627 A CN 103992627A
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Abstract
The invention discloses an environment-friendly bio-based polymer hemodialyzer casing material. The casing material is a blend which comprises the following raw materials in percentage by mass: 90-99% of environment-friendly bio-based polymer, 0.4-8% of plasticizer, 0.2-6% of lubricant, 0.1-2% of antioxidant, 0.2-3% of heat stabilizer and 0.1-4% of inorganic filler. The raw material environment-friendly bio-based polymer has the advantages of wide sources and the like, and is renewable and degradable. The prepared environment-friendly bio-based polymer hemodialyzer casing has higher biocompatibility, and can obviously lower the side effect of hemodialysis; and the waste hemodialyzer casing can be degraded by proper treatment, thereby greatly reducing the environmental pollution.
Description
Technical field
The present invention relates to environmentally friendly bio-based polymers mould material and hemodialysis field, relate in particular to a kind of environmentally friendly bio-based polymers material hemodialyzer casing material.
Background technology
Due to increasing of the increasing the weight of of mankind's aging, diabetes and hyperpietic, renal failure (renal failure) patient number is in rising trend, and hemodialysis is one of most important, effective means for the treatment of treatment renal failure disease.According to statistics, in every million people, China has every year 90～100 people chronic kidney hypofunction occurs, and the population of China surpassed 13.2 hundred million in 2007, that is to say the Chronic Renal Failure Patients of every annual meeting newly-increased approximately 130,000.The raising of the maturation of dialysis and optimization and economics of underdevelopment level makes increasing people have an opportunity to accept hemodialysis treatment, carries out in the world patient's number of hemodialysis annual just with the speed increment of 6～7 ﹪.When patient selects Hemodialysis, per week need to carry out 2～3 times, and dialyzer (kidney machine) is all disposable, so every patient probably need to use 130 dialyzers every year, according to the number of accepting hemodialysis, account for the words that 10 ﹪ of Renal Failure Patients calculate, the annual newly-increased patient of China probably need to consume 1,690,000 dialyzers, current dialysis patients total number of persons is probably 5～60,000, so annual consumption is at 650～7,800,000, and perfect along with the mechanism such as medical insurance, demand will constantly increase.
The structure of hemodialyzer changes at development, comprise drum dialyzer, wound form dialyzer, plate and frame and hollow fiber film type dialyzer, wherein, hollow fiber film type dialyzer specific surface area is large, blood using amount is few, resistance of blood flow is little, develops into gradually the principal mode of hemodialyzer.Hollow fiber film type dialyzer is comprised of hollow-fibre membrane and housing, and the two ends of hollow-fibre membrane, in Resin adhesive is fixed on housing two ends, are uniformly distributed.At present, modal on market is polyether sulphone hollow-fibre membrane, polyether sulphone is the high performance engineering plastics that a class main chain contains aromatic ring, sulfuryl and aryl oxide key etc., there is extraordinary heat and chemical stability, can sterilize by steam, β or gamma-rays, and the chemical structure of effects on surface does not produce obvious variation.Meanwhile, this class material has certain blood compatibility, is difficult for causing complement system activation, to leukocytic excite also less.Polyether sulphone has stronger hydrophobicity, with the blend of polyvinylpyrrolidone be the general method of modifying that polyether sulphone dialysis membrane is produced, polysulfones or the polyether sulfone dialysis membrane produced as Gambro, Fresenius and Membrana company.The housing of hemodialyzer is often processed by polycarbonate, and during dialyzer sterilization, polycarbonate likely decomposes and discharges dihydroxyphenyl propane, has certain potential safety hazard.
In sum, the hemodialysis film of hemodialyzer and the material of housing are mainly petroleum base polymkeric substance at present, exist poor, the easy blood coagulation of wetting ability, cannot degradation treatment etc. problem, researching and developing environmentally friendly bio-based polymers hemodialysis film and housing is the important directions of following hemodialyzer development.Application number is the preparation and modification method that 201210547368.0,201310176950.5 and 201310176928.0 Chinese invention patent discloses poly(lactic acid) hemodialysis membrane.The present invention, by the method for injection moulding, prepares the hemodialyzer casing of environmentally friendly bio-based polymers material.
Summary of the invention
The object of the invention is to overcome the deficiencies in the prior art, a kind of environmentally friendly bio-based polymers material hemodialyzer casing material is provided.
The environmentally friendly bio-based polymers material of the present invention hemodialyzer casing material is blend, comprises environmentally friendly bio-based polymers, softening agent, lubricant, antioxidant, thermo-stabilizer, mineral filler; Wherein the quality percentage composition of each raw material is as follows: environmentally friendly bio-based polymers 90～99 ﹪, softening agent 0.4～8 ﹪, lubricant 0.2～6 ﹪, antioxidant 0.1～2 ﹪, thermo-stabilizer 0.2～3 ﹪, mineral filler 0.1～4 ﹪;
Described environmentally friendly bio-based polymers is poly(lactic acid), starch, Mierocrystalline cellulose, chitosan, poly-epsilon-caprolactone, PGA, poly butyric ester or poly 3-hydroxy butyrate;
Described softening agent is tri-n-butyl citrate, ATBC, triethyl citrate, trioctyl lemon acid, ATHC or epoxy soybean oil;
Described lubricant is paraffin, calcium stearate, hydroxy silicon oil or ethylene bis stearamide;
Described antioxidant is to be secondary diarylamine, Ursol D, butanols acetal-alpha-naphthylamine or 2,6 di tert butyl 4 methyl phenol;
Described thermo-stabilizer is diphenyl thiourea, 2-phenylindone, beta-amino crotonate or Bis(lauroyloxy)dioctyltin;
Described mineral filler is silicon-dioxide, titanium dioxide, carbon nanotube, graphene oxide, polynite or hydrotalcite.
The method of preparing above-mentioned environmentally friendly bio-based polymers material hemodialyzer casing material is as follows: after environmentally friendly bio-based polymers, softening agent, lubricant, antioxidant, thermo-stabilizer, mineral filler are mixed, and injection moulding and get final product.
beneficial effect of the present invention:the environmentally friendly bio-based polymers of raw material of the present invention has wide material sources, renewable, the advantage such as can degrade.The present invention be take environmentally friendly bio-based polymers as main raw material, the hemodialyzer casing of preparing environmentally friendly bio-based polymers material by the method for injection moulding, not only can break away from the restriction of petroleum resources to hemodialyzer casing development, the hemodialyzer casing of prepared environmentally friendly bio-based polymers material has more excellent biocompatibility, can obviously reduce the side effect of hemodialysis, and discarded hemodialyzer casing can be degraded through suitable processing, greatly reduce the pollution to environment, therefore, the hemodialyzer casing of environmentally friendly bio-based polymers material has excellent development prospect.
Embodiment
Below in conjunction with embodiment, the present invention is described in more detail, but described embodiment is not construed as limiting the invention.From disclosed by the invention content associated to or all distortion of deriving, all think protection scope of the present invention.
Embodiment 1:
After 99 grams of poly(lactic acid), 0.4 gram of tri-n-butyl citrate, 0.2 gram of paraffin, 0.1 gram of secondary diarylamine, 0.2 gram of diphenyl thiourea and 0.1 gram of Nano particles of silicon dioxide are mixed, injection moulding obtains the hemodialyzer casing of 100 grams of poly(lactic acid) materials.
Embodiment 2:
After 90 grams of starch, 8 grams of ATBC, 0.5 gram of calcium stearate, 0.3 gram of Ursol D, 0.4 gram of 2-phenylindone and 0.8 gram of titanium dioxide nano-particle are mixed, injection moulding obtains 100 grams of starch material hemodialyzer casings.
Embodiment 3:
After 90 grams of Mierocrystalline celluloses, 0.5 gram of triethyl citrate, 6 grams of hydroxy silicon oils, 2 grams of butanols acetal-alpha-naphthylamines, 0.5 gram of beta-amino crotonate and 1 gram of carbon nanotube are mixed, injection moulding obtains the hemodialyzer casing of 100 grams of Mierocrystalline cellulose materials.
Embodiment 4:
After 90 grams of chitosans, 1 gram of trioctyl lemon acid, 1.5 grams of ethylene bis stearamides, 0.5 gram of 2,6 di tert butyl 4 methyl phenol, 3 grams of Bis(lauroyloxy)dioctyltins and 4 grams of graphene oxides are mixed, injection moulding obtains the hemodialyzer casing of 100 grams of chitosan materials.
Embodiment 5:
After 93 grams of PGAs, 1.5 grams of ATHCs, 0.6 gram of paraffin, 1.5 grams of secondary diarylamine, 3 grams of beta-amino crotonates and 0.4 gram of polynite are mixed, injection moulding obtains the hemodialyzer casing of 100 grams of PGA materials.
Embodiment 6:
After 96 grams of poly-epsilon-caprolactones, 1.5 grams of epoxy soybean oils, 0.4 gram of calcium stearate, 0.8 gram of butanols acetal-alpha-naphthylamine, 0.2 gram of Bis(lauroyloxy)dioctyltin and 1.1 grams of hydrotalcites are mixed, injection moulding obtains the hemodialyzer casing of 100 grams of poly-epsilon-caprolactone materials.
Embodiment 7:
After 92 grams of poly butyric esters, 2.5 grams of ATBC, 1.3 grams of calcium stearates, 1.7 grams of Ursol D, 0.5 gram of 2-phenylindone and 2 grams of Nano particles of silicon dioxide are mixed, injection moulding obtains the hemodialyzer casing of 100 grams of poly butyric ester materials.
Embodiment 8:
After 97 grams of poly 3-hydroxy butyrates, 0.5 gram of trioctyl lemon acid, 0.4 gram of hydroxy silicon oil, 1.5 grams of 2,6 di tert butyl 4 methyl phenols, 0.2 gram of beta-amino crotonate and 0.4 gram of graphene oxide are mixed, injection moulding obtains the hemodialyzer casing of 100 grams of poly 3-hydroxy butyrate materials.
Above-described embodiment is not that the present invention is not limited only to above-described embodiment for restriction of the present invention, as long as meet requirement of the present invention, all belongs to protection scope of the present invention.
Claims (7)
1. an environmentally friendly bio-based polymers material hemodialyzer casing material, is blend, it is characterized in that comprising environmentally friendly bio-based polymers, softening agent, lubricant, antioxidant, thermo-stabilizer, mineral filler; Wherein the quality percentage composition of each raw material is as follows: environmentally friendly bio-based polymers 90～99 ﹪, softening agent 0.4～8 ﹪, lubricant 0.2～6 ﹪, antioxidant 0.1～2 ﹪, thermo-stabilizer 0.2～3 ﹪, mineral filler 0.1～4 ﹪.
2. a kind of environmentally friendly bio-based polymers material hemodialyzer casing material as claimed in claim 1, is characterized in that environmentally friendly bio-based polymers is poly(lactic acid), starch, Mierocrystalline cellulose, chitosan, poly-epsilon-caprolactone, PGA, poly butyric ester or poly 3-hydroxy butyrate.
3. a kind of environmentally friendly bio-based polymers material hemodialyzer casing material as claimed in claim 1, is characterized in that softening agent is tri-n-butyl citrate, ATBC, triethyl citrate, trioctyl lemon acid, ATHC or epoxy soybean oil.
4. a kind of environmentally friendly bio-based polymers material hemodialyzer casing material as claimed in claim 1, is characterized in that lubricant is paraffin, calcium stearate, hydroxy silicon oil or ethylene bis stearamide.
5. a kind of environmentally friendly bio-based polymers material hemodialyzer casing material as claimed in claim 1, is characterized in that antioxidant is secondary diarylamine, Ursol D, butanols acetal-alpha-naphthylamine or 2,6 di tert butyl 4 methyl phenol.
6. a kind of environmentally friendly bio-based polymers material hemodialyzer casing material as claimed in claim 1, is characterized in that thermo-stabilizer is diphenyl thiourea, 2-phenylindone, beta-amino crotonate or Bis(lauroyloxy)dioctyltin.
7. a kind of environmentally friendly bio-based polymers material hemodialyzer casing material as claimed in claim 1, is characterized in that mineral filler is silicon-dioxide, titanium dioxide, carbon nanotube, graphene oxide, polynite or hydrotalcite.
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104403121A (en) * | 2014-11-26 | 2015-03-11 | 王秋芹 | Method for preparing graphene-based biodegradable composite film used in parks |
| CN104448373A (en) * | 2014-11-26 | 2015-03-25 | 王秋芹 | Carbon nanotube based bio-degradable composite film used in garden |
| CN104479162A (en) * | 2014-11-26 | 2015-04-01 | 王秋芹 | Graphene-based biodegradable composite thin film for garden |
| CN104497337A (en) * | 2014-11-26 | 2015-04-08 | 王秋芹 | Preparation method of carbon nanotube-based biodegradable composite membrane used in garden |
| CN106189148A (en) * | 2016-08-30 | 2016-12-07 | 何仁英 | Can be used for polycaprolactone material of dialysis adnexa and preparation method thereof |
| CN106589866A (en) * | 2016-11-21 | 2017-04-26 | 广州医科大学 | PCL conductive shapable material and preparation method thereof |
| CN108410200A (en) * | 2018-04-23 | 2018-08-17 | 陈萍 | A kind of production technology of degradable medical apparatus |
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| US20020002252A1 (en) * | 1995-12-21 | 2002-01-03 | Shoji Obuchi | Process for preparing formed item of aliphatic polyester and formed item prepared by the process |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104403121A (en) * | 2014-11-26 | 2015-03-11 | 王秋芹 | Method for preparing graphene-based biodegradable composite film used in parks |
| CN104448373A (en) * | 2014-11-26 | 2015-03-25 | 王秋芹 | Carbon nanotube based bio-degradable composite film used in garden |
| CN104479162A (en) * | 2014-11-26 | 2015-04-01 | 王秋芹 | Graphene-based biodegradable composite thin film for garden |
| CN104497337A (en) * | 2014-11-26 | 2015-04-08 | 王秋芹 | Preparation method of carbon nanotube-based biodegradable composite membrane used in garden |
| CN106189148A (en) * | 2016-08-30 | 2016-12-07 | 何仁英 | Can be used for polycaprolactone material of dialysis adnexa and preparation method thereof |
| CN106589866A (en) * | 2016-11-21 | 2017-04-26 | 广州医科大学 | PCL conductive shapable material and preparation method thereof |
| CN106589866B (en) * | 2016-11-21 | 2019-11-05 | 广州医科大学 | A kind of PCL conduction Plastic implant and preparation method thereof |
| CN108410200A (en) * | 2018-04-23 | 2018-08-17 | 陈萍 | A kind of production technology of degradable medical apparatus |
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Application publication date: 20140820 |