CN103990006A

CN103990006A - Traditional Chinese medicine composition for treating alcoholic liver

Info

Publication number: CN103990006A
Application number: CN201410262289.4A
Authority: CN
Inventors: 不公告发明人
Original assignee: Individual
Current assignee: Individual
Priority date: 2014-06-13
Filing date: 2014-06-13
Publication date: 2014-08-20

Abstract

The invention provides a traditional Chinese medicine composition for treating an alcoholic liver, and belongs to the technical field of traditional Chinese medicines. Particularly, the traditional Chinese medicine composition comprises the following traditional Chinese medicinal materials in parts by weight: 18-28 parts of popcorn, 10-18 parts of codonopsis pilosula, 3-12 parts of grifola, 6-12 parts of lalang grass rhizome, 6-12 parts of kadsura pepper stem, 2-6 parts of herba cistanche, 6-12 parts of radix sophorae flavescentis and 2-6 parts of chrysanthemum. Proven by clinical verification, the traditional Chinese medicine composition disclosed by the invention has the advantages of being quick in effect taking, short in treatment course, high in recovery rate and the like.

Description

A kind of Chinese medicine composition for the treatment of alcoholic liver

Technical field

The invention belongs to Chinese medicine technical field, be specifically related to a kind of Chinese medicine composition for the treatment of alcoholic liver.

Background technology

Alcoholic liver is due to the hepar damnification disease due to long-term heavy drinking.How asymptomatic slight alcoholic fatty liver is, and alcoholic fatty liver can present the performance of similar chronic hepatitis, as slight general malaise, asthenia, fatiguability, nausea and vomiting, inappetence, abdominal distention etc.As do not take effective measures, the state of an illness worsens continuation to increase the weight of, and there will be gradually alcoholic hepatitis, hepatic fibrosis and liver cirrhosis occurs.

Summary of the invention

Inventor, on the basis of ancestral side, by long-term clinical application experience, has invented the Chinese medicine composition of a kind of instant effect, short treating period, treatment alcoholic liver that cure rate is high.

The technical solution used in the present invention is as follows:

Treat a Chinese medicine composition for alcoholic liver, it is characterized in that it is made up of the Chinese crude drug of following parts by weight:

Popcorn 18-28 Radix Codonopsis 10-18 Polyporus 3-12 Rhizoma Imperatae 6-12

Caulis Piperis Kadsurae 6-12 Herba Cistanches 2-6 Radix Sophorae Flavescentis 6-12 Flos Chrysanthemi 2-6

As preferably, the Chinese medicine composition that the present invention treats alcoholic liver is made up of the Chinese crude drug of following parts by weight:

Popcorn 22 Radix Codonopsis 12 Polyporus 4 Rhizoma Imperataes 6

Caulis Piperis Kadsurae 10 Herba Cistanches 2 Radix Sophorae Flavescentis 8 Flos Chrysanthemis 6

Above-mentioned Chinese medicine composition of the present invention can add pharmaceutic adjuvant to be prepared into pill, capsule, tablet, powder, granule or oral liquid etc., preferably but be not limited to capsule.

Preferably, the preparation method of capsule of the present invention is as follows:

According to the present invention's prescription, take each raw medicinal material, through super-dry, pulverizing, to cross after 100-200 mesh sieve, the abundant mix homogeneously of medicinal powder that pulverizing is obtained, directly packs capsule into No. 0 after sterilizing.

Dosage of the present invention depends on concrete dosage form, the factors such as patient age, body weight, health status.Capsule of the present invention: every day three times, each serving 3-6 grain, warm water takes, 14 days courses for the treatment of.

Detailed description of the invention

Now, in conjunction with concrete preferred implementation further description made for the present invention, can not assert that specific embodiment of the invention is confined to these explanations.For general technical staff of the technical field of the invention, without departing from the inventive concept of the premise, can also make some simple deduction or replace, all should be considered as belonging to protection scope of the present invention.

EXAMPLE l:

Take the Chinese crude drug of following weight portion: popcorn 28g, Radix Codonopsis 16g, Polyporus 6g, Rhizoma Imperatae 12g, Caulis Piperis Kadsurae 10g, Herba Cistanches 2g, Radix Sophorae Flavescentis 8g, Flos Chrysanthemi 8g are respectively through super-dry, pulverizing, cross 100 mesh sieves, the abundant mix homogeneously of medicinal powder that pulverizing is obtained, after sterilizing, directly pack capsule into No. 0, every is loaded 0.4 gram.

Embodiment 2:

Take the Chinese crude drug of following weight portion: popcorn 28g, Radix Codonopsis 10g, Polyporus 3g, Rhizoma Imperatae 6g, Caulis Piperis Kadsurae 10g, Herba Cistanches 2g, Radix Sophorae Flavescentis 8g, Flos Chrysanthemi 8g are respectively through super-dry, pulverizing, cross 100 mesh sieves, the abundant mix homogeneously of medicinal powder that pulverizing is obtained, after sterilizing, directly pack capsule into No. 0, every is loaded 0.4 gram.

Embodiment 3:

Take the Chinese crude drug of following weight portion: popcorn 18g, Radix Codonopsis 16g, Polyporus 4g, Rhizoma Imperatae 6g, Caulis Piperis Kadsurae 6g, Herba Cistanches 6g, Radix Sophorae Flavescentis 8g, Flos Chrysanthemi 8g are respectively through super-dry, pulverizing, cross 100 mesh sieves, the abundant mix homogeneously of medicinal powder that pulverizing is obtained, after sterilizing, directly pack capsule into No. 0, every is loaded 0.4 gram.

Embodiment 4:

Take the Chinese crude drug of following weight portion: popcorn 22g, Radix Codonopsis 12g, Polyporus 4g, Rhizoma Imperatae 6g, Caulis Piperis Kadsurae 10g, Herba Cistanches 2g, Radix Sophorae Flavescentis 8g, Flos Chrysanthemi 6 are respectively through super-dry, pulverizing, cross 100 mesh sieves, the abundant mix homogeneously of medicinal powder that pulverizing is obtained, after sterilizing, directly pack capsule into No. 0, every is loaded 0.4 gram.

Embodiment 5:

Take the Chinese crude drug of following weight portion: popcorn 22g, Radix Codonopsis 12g, Polyporus 4g, Rhizoma Imperatae 6g, Caulis Piperis Kadsurae 10g, Herba Cistanches 2g, Radix Sophorae Flavescentis 8g, Flos Chrysanthemi 6 are respectively through super-dry, pulverizing, cross 100 mesh sieves, the abundant mix homogeneously of medicinal powder that pulverizing is obtained, sterilizing, add appropriate sucrose and hydroxypropyl methylcellulose, alcohol granulation, after dry, obtain granule of the present invention, every bag of 5g.

Pharmacodynamic experiment

1, animal acute toxicity test of the present invention

Medicine: the embodiment of the present invention 1 is write out a prescription.

Experimental animal: regular grade NIH mice, body weight 18g ± 2g, male and female half and half.

Method and result:

1) medicine preparation: 10g spice is pulverized, used containing the normal saline of 2% Radix Acaciae senegalis and be assigned to 150g/L suspension:

2) experiment adopts gastric infusion mode.Once daily, volume 0.2ml/10g body weight, close observation 8h also notes down, and continues to observe 7d; 3) 7d small mouse is without death, and behavior is active, and food ration is as usual, and hair color light, without loose dirty, is had a liking for saliva without fainting from fear, and eye, mouth, nose, ear and crissum are without abnormal secretions, without the rotten toe of docking.Select 5 execution, finding of naked eye: the important organs such as the heart, liver, lung, gastric and thymus, no abnormality seen changes, and shows the oral safety of this medicine.

2, long-term toxicity test for animals of the present invention

Animal: regular grade SD rat, body weight 200g ± 10g, male and female half and half.

Method and result:

1) medicine preparation: divide high, medium and low three dosage groups, be respectively 300,150,75 times of clinical application amount, with the normal saline 1:1 mixing containing 2% Radix Acaciae senegalis;

2) experiment adopts gastric infusion mode, successive administration 24d, more than i.e. 3 clinical cycles, observe animal general toxic reaction and the order of severity, after execution, check each position by rule of operation, and carry out hematology, the pathological examination of the main organs such as ALT, BUN and the heart, liver, spleen, lung, kidney, stomach;

3) long-term oral administration, there is not toxic reaction in animal.Physically well develop.Naked eyes outward appearance and main organs no abnormality seen.Peripheral hemogram and Serum ALT, BUN and matched group relatively change without pathologic.All not significant changes such as the pathological replacement heart, liver, spleen, lung, kidney, stomach, think through proved by pathology to animal without poisoning manifestations.

3, the routine clinical observation of invention formula preparation capsule treatment alcoholic liver 200

Inventor treated 200 routine alcoholic liver patients with capsule of the present invention from 2010～2014 years:

Clinical data: 200 routine patients are clinic case, minimum 20 years old of age, maximum 60 years old.

Diagnostic criteria: every day ethanol intake >=80g, be equivalent to 55 ° of Chinese liquor 150g.

Syndrome manifestations diagnosis, primary symptom: hypochondriac pain, the lower long-pending piece of the side of body.Accompanied symptoms: abdominal distention, indigestion and loss of appetite, vascular nevus, liver palm.Have one of medical history, primary symptom, 3 persons of disease that hold concurrently can make a definite diagnosis.

Therapeutic Method: usage and dosage, the capsule of preparing by the embodiment of the present invention 4, each serving 3-6 grain, every day 3 times, warm water delivery service, 14 days is the l course for the treatment of.

Criterion of therapeutical effect:

Cure: sign is improved completely, various transference cures, liver function is completely normal, and every test rating is completely normal, and patient is without any bad sensation, and diet is had a rest normal, in high spirits.

Effective: sign is significantly improved, various symptoms disappear substantially, and liver function approaches normal, and each index of correlation significantly changes, and patient is without obvious bad sensation, and diet rest normal is in high spirits.

Effective: sign obviously changes, various symptoms are improved, and liver function level promotes, and each index of correlation changes, and diet is had a rest and taken a turn for the better, and spirit better.

Invalid: sign and symptom be without improvement, liver function is without improvement sign, and each index of correlation is without changing or taking a favorable turn and abnormal.

Therapeutic outcome: this clinic accepts 200 routine alcohol fatty hepatopaths of observation for medical treatment, treated after two courses for the treatment of, recovery from illness 168 examples, and effective 28 examples, effective 4 examples, invalid 0 example, total effective rate can reach 100%.

Claims

1. treat a Chinese medicine composition for alcoholic liver, it is characterized in that it is made up of the Chinese crude drug of following parts by weight:

Popcorn 18-28 Radix Codonopsis 10-18 Polyporus 3-12 Rhizoma Imperatae 6-12

Caulis Piperis Kadsurae 6-12 Herba Cistanches 2-6 Radix Sophorae Flavescentis 6-12 Flos Chrysanthemi 2-6.

2. treat a Chinese medicine composition for alcoholic liver, preferably formed by the Chinese crude drug of following parts by weight:

Popcorn 22 Radix Codonopsis 12 Polyporus 4 Rhizoma Imperataes 6

Caulis Piperis Kadsurae 10 Herba Cistanches 2 Radix Sophorae Flavescentis 8 Flos Chrysanthemis 6.

3. treat a Chinese medicine composition for alcoholic liver, be preferably pill, capsule, tablet, powder, granule or oral liquid etc., most preferably be capsule.