CN103989817B - A kind of Chinese medicine composition for treating liver-kidney yin deficiency essential hypertension - Google Patents
A kind of Chinese medicine composition for treating liver-kidney yin deficiency essential hypertension Download PDFInfo
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- CN103989817B CN103989817B CN201410173251.XA CN201410173251A CN103989817B CN 103989817 B CN103989817 B CN 103989817B CN 201410173251 A CN201410173251 A CN 201410173251A CN 103989817 B CN103989817 B CN 103989817B
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Abstract
The present invention relates to a kind of Chinese medicine composition for treating liver-kidney yin deficiency essential hypertension, the Chinese medicine composition is made up of the bulk drug of following weight, the 20g of cultivated land 10, the 15g of dogwood fruit 9, the 20g of matrimony vine 10, the 20g of stir-baked PLASTRUM TESTUDINIS before treated with Vinegar 10, the 35g of Eclipta prostrata 25, the 21g of ripe glossy privet 15, the 20g of yncaria stem with hooks 10, the 35g of the shell of seaear 25, the 20g of radix cyathulae 10, the 35g of fushen 25, the 35g of cortex albiziae 25, the 35g of Polygonum multiflower knotweed 25, the 8g of honey-fried RADIX POLYGALAE 4.Present invention also offers the purposes of Chinese medicine composition.It is an advantage of the invention that：The all taste medicine compatibilities of the present invention are harmonious, and the TCM symptom score curative effect and blood pressure curative effect to primary hypertension patient are significantly improved, and are superior to control group, and clinic has good therapeutic effect, is worthy to be popularized.
Description
Technical field
It is that one kind treats liver-kidney yin deficiency original specifically the present invention relates to a kind of Chinese medicine composition for treating hypertension
The Chinese medicine composition of Essential hypertension.
Background technology
Essential hypertension is under the jurisdiction of motherland's medical science " dizziness ", " headache " category, and this disease is due to liver-kidney Yin deficiency so that water
Do not contain wood, be difficult to restrict liver-yang, cause liver-yang hyperactivity, it is dizziness, headache that upset, which empties hair,.Such as《Interior warp》Say：" all wind trembling and dizziness,
Come under liver ".Modern research suggests that this sick disease located in liver, is related to the five internal organs, and it is the closest in the relation of liver kidney, with mutual biography
The characteristics of becoming, intersect mixed.The deficiency of liver-yin and kidney-yin, liver-yang hyperactivity is the Common Syndromes type of hypertension.
Chinese patent literature CN201210198850.8, the applying date is on 06 04th, 2012, and patent name is controlled for one kind
Chinese medicine composition of hypertension of deficiency of yin of liver and kidney type and preparation method thereof is treated, a kind of treat in hypertension of deficiency of yin of liver and kidney type is disclosed
Drug composition.Chinese patent literature CN201310077498.7, the applying date is on 02 26th, 2013, and patent name is controlled for one kind
The Chinese medicine composition of essential hypertension is treated, a kind of Chinese medicine composition for treating essential hypertension is disclosed.But on controlling
The Chinese medicine composition for treating liver-kidney yin deficiency essential hypertension yet there are no report.
The content of the invention
The purpose of the present invention is to treat liver-kidney yin deficiency essential hypertension there is provided one kind for deficiency of the prior art
Chinese medicine composition.
Another purpose of the present invention is to provide the purposes of Chinese medicine composition.
To achieve the above object, the present invention is adopted the technical scheme that：
A kind of Chinese medicine composition for treating liver-kidney yin deficiency essential hypertension, the Chinese medicine composition is by following weight
Bulk drug is constituted, cultivated land 10-20g, dogwood fruit 9-15g, matrimony vine 10-20g, stir-baked PLASTRUM TESTUDINIS before treated with Vinegar 10-20g, Eclipta prostrata 25-35g, ripe glossy privet
15-21g, yncaria stem with hooks 10-20g, shell of seaear 25-35g, radix cyathulae 10-20g, fushen 25-35g, cortex albiziae 25-35g, Polygonum multiflower knotweed 25-
35g, honey-fried RADIX POLYGALAE 4-8g.
It is described cultivated land 12-18g, dogwood fruit 10-14g, matrimony vine 12-18g, stir-baked PLASTRUM TESTUDINIS before treated with Vinegar 12-18g, Eclipta prostrata 27-33g, ripe
Glossy privet 16-20g, yncaria stem with hooks 12-18g, shell of seaear 27-33g, radix cyathulae 12-18g, fushen 28-33g, cortex albiziae 27-33g, night hand over
Rattan 27-33g, honey-fried RADIX POLYGALAE 5-7g.
Described cultivated land 15g, dogwood fruit 12g, matrimony vine 15g, stir-baked PLASTRUM TESTUDINIS before treated with Vinegar 15g, Eclipta prostrata 30g, ripe glossy privet 18g, yncaria stem with hooks
15g, shell of seaear 30g, radix cyathulae 15g, fushen 30g, cortex albiziae 30g, Polygonum multiflower knotweed 30g, honey-fried RADIX POLYGALAE 6g.
The medicament of described Chinese medicine composition is oral liquid or syrup.
To realize above-mentioned second purpose, the present invention is adopted the technical scheme that：
Application of the Chinese medicine composition in treatment liver-kidney yin deficiency essential hypertension medicine is prepared.
The invention has the advantages that：
1st, all taste medicine compatibilities of the invention are harmonious, and the TCM symptom score curative effect and blood pressure to primary hypertension patient are treated
Effect is significantly improved, and is superior to control group, and clinic has good therapeutic effect, is worthy to be popularized；
2nd, it is made up of pure Chinese medicine, with having no toxic side effect, the low advantage of price, it is easy to be accepted by patients；
3rd, abundant raw materials, preparation technology is simple, environmentally friendly, in terms of liver-kidney yin deficiency essential hypertension is treated
There is good application prospect.
Embodiment
The preparation of the Chinese medicine composition of the treatment liver-kidney yin deficiency essential hypertension of embodiment 1
Cultivated land 10g, dogwood fruit 15g, matrimony vine 10g, stir-baked PLASTRUM TESTUDINIS before treated with Vinegar 20g, Eclipta prostrata 25g, ripe glossy privet 21g, yncaria stem with hooks 10g, Shi Jue
Bright 35g, radix cyathulae 10g, fushen 35g, cortex albiziae 25g, Polygonum multiflower knotweed 35g, honey-fried RADIX POLYGALAE 4g, are made up closed of the court's traditional Chinese medicine extracting machine
Pack concoction.
The preparation of the Chinese medicine composition of the treatment liver-kidney yin deficiency essential hypertension of embodiment 2
Cultivated land 20g, dogwood fruit 9g, matrimony vine 20g, stir-baked PLASTRUM TESTUDINIS before treated with Vinegar 10g, Eclipta prostrata 35g, ripe glossy privet 15g, yncaria stem with hooks 20g, the shell of seaear
25g, radix cyathulae 20g, fushen 25g, cortex albiziae 35g, Polygonum multiflower knotweed 25g, honey-fried RADIX POLYGALAE 8g, closed bag is made by the court's traditional Chinese medicine extracting machine
Powder charge juice.
The preparation of the Chinese medicine composition of the treatment liver-kidney yin deficiency essential hypertension of embodiment 3
Cultivated land 10g, dogwood fruit 9g, matrimony vine 20g, stir-baked PLASTRUM TESTUDINIS before treated with Vinegar 20g, Eclipta prostrata 25g, ripe glossy privet 15g, yncaria stem with hooks 20g, the shell of seaear
35g, radix cyathulae 10g, fushen 25g, cortex albiziae 35g, Polygonum multiflower knotweed 35g, honey-fried RADIX POLYGALAE 4g, closed bag is made by the court's traditional Chinese medicine extracting machine
Powder charge juice.
The preparation of the Chinese medicine composition of the treatment liver-kidney yin deficiency essential hypertension of embodiment 4
Cultivated land 20g, dogwood fruit 15g, matrimony vine 10g, stir-baked PLASTRUM TESTUDINIS before treated with Vinegar 10g, Eclipta prostrata 35g, ripe glossy privet 21g, yncaria stem with hooks 10g, Shi Jue
Bright 25g, radix cyathulae 20g, fushen 35g, cortex albiziae 25g, Polygonum multiflower knotweed 25g, honey-fried RADIX POLYGALAE 8g, are made up closed of the court's traditional Chinese medicine extracting machine
Pack concoction.
The preparation of the Chinese medicine composition of the treatment liver-kidney yin deficiency essential hypertension of embodiment 5
Cultivated land 12g, dogwood fruit 14g, matrimony vine 12g, stir-baked PLASTRUM TESTUDINIS before treated with Vinegar 18g, Eclipta prostrata 27g, ripe glossy privet 20g, yncaria stem with hooks 12g, Shi Jue
Bright 33g, radix cyathulae 12g, fushen 33g, cortex albiziae 27g, Polygonum multiflower knotweed 33g, honey-fried RADIX POLYGALAE 5g, are made up closed of the court's traditional Chinese medicine extracting machine
Pack concoction.
The preparation of the Chinese medicine composition of the treatment liver-kidney yin deficiency essential hypertension of embodiment 6
Cultivated land 18g, dogwood fruit 10g, matrimony vine 18g, stir-baked PLASTRUM TESTUDINIS before treated with Vinegar 12g, Eclipta prostrata 33g, ripe glossy privet 16g, yncaria stem with hooks 18g, Shi Jue
Bright 27g, radix cyathulae 18g, fushen 27g, cortex albiziae 33g, Polygonum multiflower knotweed 27g, honey-fried RADIX POLYGALAE 7g, are made up closed of the court's traditional Chinese medicine extracting machine
Pack concoction.
The preparation of the Chinese medicine composition of the treatment liver-kidney yin deficiency essential hypertension of embodiment 7
Cultivated land 12g, dogwood fruit 10g, matrimony vine 18g, stir-baked PLASTRUM TESTUDINIS before treated with Vinegar 18g, Eclipta prostrata 27g, ripe glossy privet 16g, yncaria stem with hooks 18g, Shi Jue
Bright 33g, radix cyathulae 12g, fushen 27g, cortex albiziae 33g, Polygonum multiflower knotweed 33g, honey-fried RADIX POLYGALAE 5g, are made up closed of the court's traditional Chinese medicine extracting machine
Pack concoction.
The preparation of the Chinese medicine composition of the treatment liver-kidney yin deficiency essential hypertension of embodiment 8
Cultivated land 18g, dogwood fruit 14g, matrimony vine 12g, stir-baked PLASTRUM TESTUDINIS before treated with Vinegar 12g, Eclipta prostrata 33g, ripe glossy privet 20g, yncaria stem with hooks 12g, Shi Jue
Bright 27g, radix cyathulae 18g, fushen 33g, cortex albiziae 27g, Polygonum multiflower knotweed 27g, honey-fried RADIX POLYGALAE 7g, are made up closed of the court's traditional Chinese medicine extracting machine
Pack concoction.
The preparation of the Chinese medicine composition of the treatment liver-kidney yin deficiency essential hypertension of embodiment 9
Cultivated land 15g, dogwood fruit 12g, matrimony vine 15g, stir-baked PLASTRUM TESTUDINIS before treated with Vinegar 15g, Eclipta prostrata 30g, ripe glossy privet 18g, yncaria stem with hooks 15g, Shi Jue
Bright 30g, radix cyathulae 15g, fushen 30g, cortex albiziae 30g, Polygonum multiflower knotweed 30g, honey-fried RADIX POLYGALAE 6g, are made up closed of the court's traditional Chinese medicine extracting machine
Pack concoction.
The preparation of the Chinese medicine composition of the treatment liver-kidney yin deficiency essential hypertension of embodiment 10
Any described Chinese medicine compositions of Example 1-9, plus 9-11 times measured water, is decocted the shell of seaear 30 minutes, then will
Remaining medicine in addition to yncaria stem with hooks is put into decoction 30-60 minutes together, and in decoction, soon cooked first 3-5 minutes is put into yncaria stem with hooks, finally
Well-done Chinese medicine is filtered out into concoction, stood, airtight package concoction is made by the court's traditional Chinese medicine extracting machine in leaching supernatant.
The experiment of the present invention treatment liver-kidney yin deficiency essential hypertension of embodiment 11
1 data and method
1.1 case selection
1.1.1 inclusive criteria Western medicine diagnostic criteria reference《2010 Chinese hypertension prevention and control guides》(third edition), meets
2 grades of high blood pressure（Moderate）Person, i.e. systolic pressure 160-179mmHg, wherein diastolic pressure 100-109mmHg, diastolic pressure and systolic pressure
Satisfaction one is i.e. diagnosable；TCM syndrome diagosis reference《New Chinese medicine guideline of clinical investigations》Dialectical category syndrome of hyperactivity of yang due to yin deficiency
Person.
1.1.2 exclusion standard reference《New Chinese medicine guideline of clinical investigations》.
1.3 group cases 100 are the patient for moving in worry section of our hospital for 2 months to 2014 in March, 2013.With
Machine is divided into control group, treatment group 1, treatment group 2, treatment group 3 and treatment group 4 each 20.
1.2 treatment method control groups：On the basis of customary medical treatment, olmesartan medoxomil tablet 20mg is given（Give birth in Beijing ten thousand
Medicine company Co., Ltd, Chinese medicines quasi-word H20061312）Orally, each 20mg, one time a day；Treatment group 1：In control group treatment
On the basis of add embodiment 1 preparation Chinese medicine composition, daily 1 dose, take in two times；Treatment group 2：On the basis of control group treatment
The Chinese medicine composition of the preparation of embodiment 4 is added, daily 1 dose, is taken in two times；Treatment group 3：Reality is added on the basis of control group treatment
The Chinese medicine composition of the preparation of example 6 is applied, daily 1 dose, is taken in two times；Treatment group 4：Embodiment 9 is added on the basis of control group treatment
The Chinese medicine composition of preparation, takes in two times by daily 1 dose.Each group is treated 4 weeks.
1.3 observation index
1.3.1 health giving quality observation index
It is invalid：Above standard person is not reached.
1.3.1.1 tcm syndrome curative effect reference《New Chinese medicine guideline of clinical investigations》By dizziness, headache, the soreness of waist, knee
The clinical symptoms such as soft, dysphoria in chestpalms-soles, insomnia, palpitaition, tinnitus, forgetful, tongue red few tongue, small and wiry pulse or number by without, it is light, in, divide again
Not Ji 0,2,4,6 points；Tongue, arteries and veins are by having, no record.
1.3.1.2 blood pressure determination：Specifically measurement and computational methods are equal with reference to 2010 Chinese hypertension prevention and control guides for blood pressure
The method that measurement blood pressure is told in (third edition), the pressure value of record treatment 0 week and treatment measurement in 4 weeks.
1.3.2 safety observations index
1.3.2.1 blood, urine, stool routine examination and hepatic and renal function are checked before and after being treated to patient.
1.3.2.2 the adverse reaction situation during recording medicine.
1.4 efficacy assessment standard
1.4.1 tcm clinical practice symptom curative effect was with reference to 2002《New Chinese medicine guideline of clinical investigations》.It is effective：It is clinical
Symptom, sign are obviously improved, the % of syndrome integral Jian Shao≤70；Effectively：Clinical symptoms, sign are taken a favorable turn, and syndrome integral is reduced
The % of 30 %~70（Containing 30%）；It is invalid：Clinical symptoms, sign are not improved, even aggravating, syndrome integral is reduced< 30 %；Plus
Weight：Clinical symptoms, sign have syndrome integral after exacerbation, treatment to exceed before treatment.
1.4.2 blood pressure curative effect determinate standard was with reference to 2002《New Chinese medicine guideline of clinical investigations》.It is effective：Diastole
More than drops 10mmHg, though and reach that normal range (NR) or diastolic pressure do not drop to normal range (NR), be reduced to more than 20mmHg；Have
Effect：Diastole drops have reached that normal range (NR) or diastolic pressure decline 10-19mmHg earlier above not as good as more than 10mmHg, but not yet
Decline more than 30mmHg earlier above up to normal range (NR) or systolic pressure；It is invalid：Above standard person is not reached.
1.5 statistical methods use SPSS18.0 statistical analysis systems.If measured value is in normal distribution, with±S
Represent, if in Non-Gaussian Distribution, being represented with median；In the data of Non-Gaussian Distribution, give non-parametric rank sum test；Grade is provided
Material gives non-parametric rank sum test.
2 results
2.1 5 groups of tcm clinical practice symptom therapeutic evaluatioies are compared
2.1.1 before five groups of treatments（0 week）TCM symptom score：
Treatment group 1：16.56 ± 0.99, treatment group 2：16.48 ± 0.99, treatment group 3：16.65 ± 0.99, treatment group 4：
16.61 ± 0.99, control group：17.67 ± 1.01, each treatment group is compared with control group, P1=0.9745, P2=0.9805, P3=
0.9794, P4=0.9698, no significant difference.
2.1.2 after five groups of treatments（4 weeks）TCM symptom score therapeutic evaluation is compared
After 1 five groups of treatments of table（4 weeks）TCM symptom score therapeutic evaluation is compared
After five groups of treatments（4 weeks）TCM symptom score therapeutic evaluation is compared, and each treatment group is superior to control group（P1=
0.0085, P2=0.0081, P3=0.0080, P4=0.0088）.
2.2 5 groups of blood pressure therapeutic evaluatioies are compared
2.2.1 before five groups of treatments（0 week）Pressure value：
Treatment group 1：Mean blood pressure 169.84 ± 0.67/105.33 ± 0.78；Treatment group 2：Mean blood pressure 169.94 ±
0.67/105.43±0.78；Treatment group 3：Mean blood pressure 169.89 ± 0.67/105.47 ± 0.78；Treatment group 4：Mean blood pressure
169.90±0.67/105.55±0.78；Control group：Mean blood pressure：170.67 ± 1.03/106.13 ± 0.98, each treatment group
Compared with control group, P1=0.8654, P2=0.8692, P3=0.8704, P4=0.8587, no significant difference.
2.2.2 after five groups of treatments（4 weeks）Blood pressure therapeutic evaluation is compared
After 2 five groups of treatments of table（4 weeks）Blood pressure therapeutic evaluation is compared
After five groups of treatments（4 weeks）Blood pressure therapeutic evaluation is compared, and each treatment group is superior to control group（P1=0.0094, P2=
0.0092, P3=0.0097, P4=0.0093）.
2.4 adverse reactions do not find that patient has the obvious adverse reactions such as bleeding, fash over the course for the treatment of and after treatment
Occur, two groups of blood, urine, stool routine examination and hepatic and renal function inspection are showed no anomalous variation.
Described above is only the preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
Member, on the premise of the inventive method is not departed from, can also make some improvement and supplement, and these are improved and supplement also should be regarded as
Protection scope of the present invention.
Claims (2)
1. a kind of Chinese medicine composition for treating liver-kidney yin deficiency essential hypertension, it is characterised in that the Chinese medicine composition by
The bulk drug composition of following weight：Cultivated land 15g, dogwood fruit 12g, matrimony vine 15g, stir-baked PLASTRUM TESTUDINIS before treated with Vinegar 15g, Eclipta prostrata 30g, ripe glossy privet 18g,
Yncaria stem with hooks 15g, shell of seaear 30g, radix cyathulae 15g, fushen 30g, cortex albiziae 30g, Polygonum multiflower knotweed 30g, honey-fried RADIX POLYGALAE 6g；Described Chinese medicine group
The medicament of compound is oral liquid or syrup.
2. application of the Chinese medicine composition in treatment liver-kidney yin deficiency essential hypertension medicine is prepared described in claim 1.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104984028A (en) * | 2015-06-05 | 2015-10-21 | 李跃 | Blood pressure reduction foot bath traditional Chinese medicine for treating liver and kidney yin deficiency type hypertension |
| CN110464806B (en) * | 2019-09-03 | 2021-08-20 | 上海市静安区中医医院 | Traditional Chinese medicine composition for treating yin deficiency and yang excess type primary hypertension and application thereof |
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| CN101085234A (en) * | 2007-06-26 | 2007-12-12 | 北京艺信堂医药研究所 | Traditional Chinese medicine preparation for treating dizziness during menstruation |
| CN101549088A (en) * | 2008-04-03 | 2009-10-07 | 北京中科仁和科技有限公司 | Traditional Chinese medicine for treating neurasthenia and preparation method thereof |
| CN102366585A (en) * | 2011-09-28 | 2012-03-07 | 邓华伦 | Chinese herbal medicine for treating headache caused by yin deficiency of liver and kidney, hyperactivity of liver-yang and stagnation of spleen |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101085234A (en) * | 2007-06-26 | 2007-12-12 | 北京艺信堂医药研究所 | Traditional Chinese medicine preparation for treating dizziness during menstruation |
| CN101549088A (en) * | 2008-04-03 | 2009-10-07 | 北京中科仁和科技有限公司 | Traditional Chinese medicine for treating neurasthenia and preparation method thereof |
| CN102366585A (en) * | 2011-09-28 | 2012-03-07 | 邓华伦 | Chinese herbal medicine for treating headache caused by yin deficiency of liver and kidney, hyperactivity of liver-yang and stagnation of spleen |
Non-Patent Citations (2)
| Title |
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| 养血安神夜交藤;沈尔安;《开卷有益(求医问药)》;20070802(第08期);32-33 * |
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