CN103989737A - Preparation method for pharmaceutical composition for treating chronic pelvic inflammation - Google Patents
Preparation method for pharmaceutical composition for treating chronic pelvic inflammation Download PDFInfo
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- CN103989737A CN103989737A CN201410219759.9A CN201410219759A CN103989737A CN 103989737 A CN103989737 A CN 103989737A CN 201410219759 A CN201410219759 A CN 201410219759A CN 103989737 A CN103989737 A CN 103989737A
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Abstract
The invention discloses a preparation method for a pharmaceutical composition for treating chronic pelvic inflammation. The method comprises the following steps: (1), adding 6000 ml of water into material medicines, heating and refluxing for 6 hours in a flask with a condensing tube, and then filtering to obtain a filtrate 1 and a filter residue 1; (2), adding 6000ml of water into the filter residue 1, heating for 5 hours in the flask with the condensing tube, and filtering to obtain a filtrate 2 and a filter residue 2; (3), adding 5000 ml of water into the filter residue 2, heating for 3 hours in the flask with the condensing tube, and filtering to obtain filtrate 3 and filter residue 3; (4), combining the filtrate 1, the filtrate 2 and the filtrate 3, concentrating to 6000 ml, and cooling to the room temperature to obtain the pharmaceutical composition. The pharmaceutical composition, which is prepared by the method disclosed by the invention, for treating chronic pelvic inflammation has the characteristics of being exact in curative effect, safe and convenient, free of toxic and side effect, and low in price.
Description
Technical field
The present invention relates to field of medicaments, relate in particular to a kind of preparation method for the treatment of the pharmaceutical composition of chronic pelvic inflammatory disease.
Background technology
Chronic pelvic inflammatory disease is more common gynaecopathia, and often for acute pelvic inflammatory disease fails thoroughly to treat, or patient's body constitution is poor, due to the course of disease is delayed, but also can NAI medical history.The state of an illness is more obstinate, when Abwehrkraft des Koepers is poor, can have acute attack.Doctor trained in Western medicine be take anti-inflammatory treatment as main, but unsatisfactory curative effect.
Summary of the invention
The object of this invention is to provide a kind of preparation method for the treatment of the pharmaceutical composition of chronic pelvic inflammatory disease.
In order to realize object of the present invention, the invention provides a kind of preparation method for the treatment of the pharmaceutical composition of chronic pelvic inflammatory disease, the method comprises the following steps:
1) in crude drug, add 6000 ml waters, in the flask of condensing tube is housed, reflux is 6 hours, then filters, and obtains filtrate 1 and filtering residue 1;
2) in filtering residue 1, add 6000 ml waters, in the flask of condensing tube is housed, heat 5 hours, filter, obtain filtrate 2 and filtering residue 2;
3) in filtering residue 2, add 5000 ml waters, in the flask of condensing tube is housed, heat 3 hours, filter, obtain filtrate 3 and filtering residue 3; And
4) merge described filtrate 1, filtrate 2 and filtrate 3, be concentrated into 6000 milliliters, be cooled to room temperature, obtain.
Preferably, the material that described crude drug comprises following weight portion: very heavy group of 1-20 part, Caulis Mahoniae 1-10 part, Herba Andrographis 1-10 part, Radix Codonopsis 1-15 part, Cortex Eucommiae 1-15 part, Radix Glycyrrhizae 1-10 part and Caulis Spatholobi 1-10 part.
Preferably, the material that described crude drug comprises following weight portion: very heavyly dial 6 parts of 10 parts, 8 parts of Caulis Mahoniaes, 6 parts of Herba Andrographis, 10 parts of Radix Codonopsis, 12 parts of the Cortexs Eucommiae, 9 parts, Radix Glycyrrhizae and Caulis Spatholobis.
Preferably, described crude drug also comprises the material of following weight portion: Conyza canadensis (L.) Cronq. 10-30 part, Herba Plantaginis 1-10 part, Radix seu Fructus Actinidiae Purpureae 10-20 part, Semen Ziziphi Spinosae 1-10 part, horse Auricled Hedyotis Herb 10-30 part, Fructus Jujubae 1-20 part, water Semen Sojae Preparatum 1-20 part, Fructus Gardeniae 1-10 part, Herba Epilobii Pyrricholophi 10-20 part, Fructus Cnidii 10-20 part, Herba Tagetis Patulae 1-20 part, Cortex Phellodendri 10-20 part, water hair are penetrated 1-20 part, Radix Paeoniae Rubra 10-20 part and Radix Rehmanniae Preparata 1-10 part.
Preferably, described crude drug also comprises the material of following weight portion: 15 parts of Conyza canadensis (L.) Cronq.s, 8 parts of Herba Plantaginiss, 16 parts of Radix seu Fructus Actinidiae Purpureaes, 9 parts of Semen Ziziphi Spinosaes, 20 parts of horse Auricled Hedyotis Herbs, 10 parts of Fructus Jujubaes, 10 parts of water Semen Sojae Preparatums, 8 parts of Fructus Gardeniaes, 12 parts of Herba Epilobii Pyrricholophi, 15 parts of Fructus Cnidiis, 10 parts of Herba Tagetis Patulaes, 12 parts of Cortex Phellodendris, water hair are penetrated 7 parts of 10 parts, 11 parts of Radix Paeoniae Rubra and Radix Rehmanniae Preparata.
In the present invention: Radix seu Fructus Actinidiae Purpureae is root or the fruit of Actinidiaceae plant purple actinidia (Actinidia purpurea).Horse Auricled Hedyotis Herb is the herb of Commelianaceae plant meal bag grass.Water Semen Sojae Preparatum is the herb of Lythraceae plant roundleaf mexicana.Herba Epilobii Pyrricholophi is the Herb of the long seed LIUYECAI of Folium Salicis Babylonicae Lay kind of plant.Water hair is penetrated the herb into labiate water Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis).Wherein, horse Auricled Hedyotis Herb and Radix seu Fructus Actinidiae Purpureae are monarch drug, very heavy group, Caulis Mahoniae, Herba Andrographis, Radix Codonopsis, Conyza canadensis (L.) Cronq., Herba Plantaginis, water Semen Sojae Preparatum, Fructus Gardeniae, Herba Epilobii Pyrricholophi, Fructus Cnidii, Caulis Spatholobi are ministerial drug, the Cortex Eucommiae, Semen Ziziphi Spinosae, Fructus Jujubae, Herba Tagetis Patulae, Cortex Phellodendri, water hair are penetrated, Radix Paeoniae Rubra and Radix Rehmanniae Preparata are adjuvant drug, and Radix Glycyrrhizae is for making medicine.
The reasonable recipe of the pharmaceutical composition of the treatment chronic pelvic inflammatory disease that the method for the invention makes, has determined curative effect, safe ready, has no side effect, cheap feature.
The specific embodiment
Below by embodiment, further illustrate the present invention.It should be understood that embodiments of the invention are for the present invention rather than limitation of the present invention are described.The simple modifications that essence according to the present invention is carried out the present invention all belongs to the scope of protection of present invention.Except as otherwise noted, the percent otherwise in the present invention is percetage by weight.
Embodiment enema of the present invention
Take and very heavyly dial 10 grams, 8 grams of Caulis Mahoniaes, 6 grams of Herba Andrographis, 10 grams of Radix Codonopsis, 12 grams of the Cortexs Eucommiae, 9 grams, Radix Glycyrrhizae, 6 grams of Caulis Spatholobis, 15 grams of Conyza canadensis (L.) Cronq.s, 8 grams of Herba Plantaginiss, 16 grams of Radix seu Fructus Actinidiae Purpureaes, 9 grams of Semen Ziziphi Spinosaes, 20 grams of horse Auricled Hedyotis Herbs, 10 grams of Fructus Jujubaes, 10 grams of water Semen Sojae Preparatums, 8 grams of Fructus Gardeniaes, 12 grams of Herba Epilobii Pyrricholophi, 15 grams of Fructus Cnidiis, 10 grams of Herba Tagetis Patulaes, 12 grams of Cortex Phellodendris, water hair and penetrate 7 grams of 10 grams, 11 grams of Radix Paeoniae Rubra and Radix Rehmanniae Preparata, add 6000 ml waters, in the flask of condensing tube is housed, reflux is 6 hours, then filter, obtain filtrate 1 and filtering residue 1; 2) in filtering residue 1, add 6000 ml waters, in the flask of condensing tube is housed, heat 5 hours, filter, obtain filtrate 2 and filtering residue 2; 3) in filtering residue 2, add 5000 ml waters, in the flask of condensing tube is housed, heat 3 hours, filter, obtain filtrate 3 and filtering residue 3; And 4) merge described filtrate 1, filtrate 2 and filtrate 3, be concentrated into 6000 milliliters, be cooled to room temperature, obtain.
Experimental example
Select chronic pelvic inflammatory disease 113 examples, all from the court in January, 2012-2013 year December outpatient service and inpatient.Age 22-43 year, average (31.6 ± 2.3) year; Course of disease 0.5-2.5, average (1.1 ± 1.8) year; Married 82 examples, unmarried 31 examples; 75 examples have pregnant history, artificial abortion's history 56 examples, ectopic pregnancy history of operation 4 examples, BH 59 examples (wherein cesarean 25 examples).Symptom: lower abdomen falling inflation pain, lumbosacral region is ached, and menstruation and leucorrhoea grow in quantity can be accompanied low grade fever.Gynecologial examination: position after uterus is many, limitation of activity, tenderness; One side or bilateral adnexa place can lay one's hand on and streak thing or lamellar thickens or enclosed mass, have tenderness.Lab testing: routine blood test: WBC normal or minority are higher, neutral classification minority is higher; Ultrasound diagnosis: uterus increases (uterine cavity >7.5cm) 56 examples, and a side adnexa thickens 63 examples, and bilateral adnexa thickens 40 examples, pelvic lump 12 examples, pelvic hydrops 37 examples.Get rid of other gynaecopathias.By medical order, patient is divided into treatment group 57 examples and matched group 56 examples.Two groups of ages, the course of disease, the equal statistical analysis comparison of the state of an illness, no significant difference (P>0.05), has comparability.
Diagnostic criteria
All cases all meet the diagnostic criteria of " leukorrhagia " in the < < traditional Chinese medical science disease diagnostic criteria > > that State Administration of Traditional Chinese Medicine issues.All doctor trained in Western medicine chronic pelvic inflammatory diseases that meets diagnose or accompany pelvic lump person all can include in.
Treatment group utilizes the enema of preparing in embodiment to treat.In when treatment, make enema be preheating to 37 ℃, patient gets left lateral position, with No. 18 about 17cm of catheter inserting people anus, about rectum and sigmoid colon transitional areas, raises buttocks rest 30min, morning and evening respectively 1 time after slowly injecting 50ml medicinal liquid with 50ml syringe.It within 10 days, was 1 course for the treatment of.
The oral FUKE QIANJIN PIAN of matched group (a thousand pieces of gold Pharmaceutical) is treated, every day three times, each 6.It within 10 days, was 1 course for the treatment of.
Criterion of therapeutical effect
Clinical cure: symptom and sign disappears; The streak thing of gynecologial examination or enclosed mass disappear; Body temperature is normal; Ultrasound diagnosis uterus, adnexa normal in size, enclosed mass, pelvic hydrops disappear.Effective: symptom and sign most improves; The streak thing of gynecologial examination or enclosed mass disappear over half; Body temperature is normal; Ultrasound diagnosis uterus increases and to dwindle over halfly, and adnexa thickens, pelvic lump, pelvic hydrops improve over half.Effective: symptom and sign partly disappears or alleviates; The streak thing of gynecologial examination or enclosed mass dwindle nearly 1/3; Body temperature normal; Ultrasound diagnosis uterus increases, adnexa thickens, pelvic lump, pelvic hydrops improve nearly 1/3.Invalid: symptom and sign part increases the weight of without alleviating or having; Even the unchanged increase of the streak thing of gynecologial examination or enclosed mass; Body temperature normal or low grade fever; Ultrasound diagnosis is unchanged or increase the weight of.
Therapeutic outcome
After treatment, clinical cure 32 examples in treatment group, effective 13 examples, effective 12 examples, total effective rate 100%.Clinical cure 13 examples in matched group, effective 12 examples, effective 13 examples, invalid 18 examples, total effective rate 67.86%.Matched group has been followed up a case by regular visits to 5 routine effective patients for 6 months repeatedly.
Claims (5)
1. a preparation method for the treatment of the pharmaceutical composition of chronic pelvic inflammatory disease, is characterized in that, the method comprises the following steps:
1) in crude drug, add 6000 ml waters, in the flask of condensing tube is housed, reflux is 6 hours, then filters, and obtains filtrate 1 and filtering residue 1;
2) in filtering residue 1, add 6000 ml waters, in the flask of condensing tube is housed, heat 5 hours, filter, obtain filtrate 2 and filtering residue 2;
3) in filtering residue 2, add 5000 ml waters, in the flask of condensing tube is housed, heat 3 hours, filter, obtain filtrate 3 and filtering residue 3; And
4) merge described filtrate 1, filtrate 2 and filtrate 3, be concentrated into 6000 milliliters, be cooled to room temperature, obtain.
2. the preparation method of the pharmaceutical composition for the treatment of chronic pelvic inflammatory disease according to claim 1, it is characterized in that the material that described crude drug comprises following weight portion: very heavy group of 1-20 part, Caulis Mahoniae 1-10 part, Herba Andrographis 1-10 part, Radix Codonopsis 1-15 part, Cortex Eucommiae 1-15 part, Radix Glycyrrhizae 1-10 part and Caulis Spatholobi 1-10 part.
3. the preparation method of the pharmaceutical composition for the treatment of chronic pelvic inflammatory disease according to claim 2, it is characterized in that the material that described crude drug comprises following weight portion: very heavyly dial 6 parts of 10 parts, 8 parts of Caulis Mahoniaes, 6 parts of Herba Andrographis, 10 parts of Radix Codonopsis, 12 parts of the Cortexs Eucommiae, 9 parts, Radix Glycyrrhizae and Caulis Spatholobis.
4. the preparation method of the pharmaceutical composition for the treatment of chronic pelvic inflammatory disease according to claim 3, it is characterized in that, described crude drug also comprises the material of following weight portion: Conyza canadensis (L.) Cronq. 10-30 part, Herba Plantaginis 1-10 part, Radix seu Fructus Actinidiae Purpureae 10-20 part, Semen Ziziphi Spinosae 1-10 part, horse Auricled Hedyotis Herb 10-30 part, Fructus Jujubae 1-20 part, water Semen Sojae Preparatum 1-20 part, Fructus Gardeniae 1-10 part, Herba Epilobii Pyrricholophi 10-20 part, Fructus Cnidii 10-20 part, Herba Tagetis Patulae 1-20 part, Cortex Phellodendri 10-20 part, water hair are penetrated 1-20 part, Radix Paeoniae Rubra 10-20 part and Radix Rehmanniae Preparata 1-10 part.
5. the preparation method of the pharmaceutical composition for the treatment of chronic pelvic inflammatory disease according to claim 4, it is characterized in that, described crude drug also comprises the material of following weight portion: 15 parts of Conyza canadensis (L.) Cronq.s, 8 parts of Herba Plantaginiss, 16 parts of Radix seu Fructus Actinidiae Purpureaes, 9 parts of Semen Ziziphi Spinosaes, 20 parts of horse Auricled Hedyotis Herbs, 10 parts of Fructus Jujubaes, 10 parts of water Semen Sojae Preparatums, 8 parts of Fructus Gardeniaes, 12 parts of Herba Epilobii Pyrricholophi, 15 parts of Fructus Cnidiis, 10 parts of Herba Tagetis Patulaes, 12 parts of Cortex Phellodendris, water hair are penetrated 7 parts of 10 parts, 11 parts of Radix Paeoniae Rubra and Radix Rehmanniae Preparata.
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Cited By (1)
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CN108721404A (en) * | 2018-06-14 | 2018-11-02 | 郑州创客科技有限公司 | A kind of Chinese medicine composition and preparation method thereof promoting Recovery |
Citations (1)
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CN101036716A (en) * | 2006-03-15 | 2007-09-19 | 仁和(集团)发展有限公司 | Method of preparing Chinese traditional medicine composition for curing gynecopathy |
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CN101036716A (en) * | 2006-03-15 | 2007-09-19 | 仁和(集团)发展有限公司 | Method of preparing Chinese traditional medicine composition for curing gynecopathy |
Non-Patent Citations (1)
Title |
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朱彬,等: ""针灸结合中药灌肠治疗慢性盆腔炎113例"", 《四川中医》 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
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CN108721404A (en) * | 2018-06-14 | 2018-11-02 | 郑州创客科技有限公司 | A kind of Chinese medicine composition and preparation method thereof promoting Recovery |
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