CN103988849A - Process for preparing compound iodine disinfectant - Google Patents
Process for preparing compound iodine disinfectant Download PDFInfo
- Publication number
- CN103988849A CN103988849A CN201410229072.3A CN201410229072A CN103988849A CN 103988849 A CN103988849 A CN 103988849A CN 201410229072 A CN201410229072 A CN 201410229072A CN 103988849 A CN103988849 A CN 103988849A
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- CN
- China
- Prior art keywords
- iodine
- solution
- chlorhexidine acetate
- povidone
- disinfectant
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a process for preparing a compound iodine disinfectant. The process comprises the following steps: substituting elemental iodine by adopting povidone-iodine, and dissolving povidone-iodine to form a solution A by using water; dissolving chlorhexidine acetate to form a solution B by using a solvent, mixing the solution A and the solution B, and preparing the compound iodine disinfectant. According to the method, the elemental iodine is substituted by adopting povidone-iodine, and chlorhexidine acetate is dissolved by using a solvent, namely octaphenyl polyoxyethyiene solution or alcoholic solution, so that complexing between the elemental iodine and chlorhexidine acetate is avoided, the content of free iodine and chlorhexidine acetate in the compound iodine disinfectant is ensured, and the solution stability of povidone-iodine and chlorhexidine acetate can be promoted.
Description
Technical field
The present invention relates to thimerosal production technical field, be specifically related to a kind of preparation technology of iodine composite disinfectant.
Background technology
Iodine is a kind of conventional disinfectant, can be widely used in the sterilization of skin, mucous membrane, apparatus and article, and its bactericidal mechanism is commonly considered as iodination and the destruction to cellulosa based on iodine.Free-iodine can be directly and mycoprotein and bacterial enzyme albumen generation halogenation, thereby the biologically active of destroying albumen causes microbial death.Chlorhexidine acetate is cationic surfactant, and has a broad antifungal spectrum has killing action to most Grain-positives and negative bacteria, also effective to Pseudomonas aeruginosa, and remote holder, skin, planing surface and sterilization of instruments can be used for performing the operation.The main active ingredient of current iodic disinfecting liquid is iodine and chlorhexidine acetate, and iodine and chlorhexidine acetate recombination energy significantly improve the bactericidal effect of single component.But according to experiment, observe, iodine and chlorhexidine acetate easily form complex compound, can cause like this reduction of iodine and chlorhexidine acetate effective content, stability decreases.
Summary of the invention
The invention provides a kind of preparation technology of iodine composite disinfectant, to solve iodine that prior art exists and chlorhexidine acetate, easily form complex compound and cause iodine and chlorhexidine acetate effective content to reduce and the problem of poor stability.
The technical solution adopted for the present invention to solve the technical problems is:
A preparation technology for iodine composite disinfectant, adopts povidone iodine to replace iodine, uses water-soluble solution to form A solution povidone iodine; Use solvent that chlorhexidine acetate is dissolved and forms B solution, A solution and B solution are mixed, make iodine composite disinfectant.
Above-mentioned solvent is OPEO solution or alcoholic solution.
In above-mentioned povidone iodine, iodine quality content is 8%-12%, and the mass content of chlorhexidine acetate is 99%.
The inventive method adopts povidone iodine to replace iodine, use solvent OPEO solution or alcoholic solution to dissolve chlorhexidine acetate simultaneously, so not only avoided the complexing of iodine and chlorhexidine acetate, guarantee free-iodine in iodine composite disinfectant and the content of chlorhexidine acetate, can also promote the stability of solution of povidone iodine and chlorhexidine acetate simultaneously.
Embodiment
Example 1
A preparation technology for iodine composite disinfectant, adopts povidone iodine to replace iodine, and in povidone iodine, iodine quality content is 8.2%, uses the water-soluble solution of 31.5kg to form A solution 1.87kg povidone iodine; Use OPEO solution that 0.5kg chlorhexidine acetate is dissolved and forms B solution, the mass content of chlorhexidine acetate is 99%, A solution and B solution is mixed, then add 63.5kg water to mix, and makes 100L iodine composite disinfectant.
Example 2
A preparation technology for iodine composite disinfectant, adopts povidone iodine to replace iodine, and in povidone iodine, iodine quality content is 10.68%, uses the water-soluble solution of 31.5kg to form A solution 1.87kg povidone iodine; Use the alcohol of 15kg95% that 0.5kg chlorhexidine acetate is dissolved and forms B solution, the mass content of chlorhexidine acetate is 99%, A solution and B solution is mixed, then add 53.5kg alcohol to mix, and makes 100L iodine composite disinfectant.
Claims (2)
1. a preparation technology for iodine composite disinfectant, is characterized in that adopting povidone iodine to replace iodine, uses water-soluble solution to form A solution povidone iodine; Use solvent that chlorhexidine acetate is dissolved and forms B solution, A solution and B solution are mixed, make iodine composite disinfectant.
2. the preparation technology of iodine composite disinfectant according to claim 1, is characterized in that solvent is OPEO solution or alcoholic solution.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410229072.3A CN103988849A (en) | 2014-05-21 | 2014-05-21 | Process for preparing compound iodine disinfectant |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410229072.3A CN103988849A (en) | 2014-05-21 | 2014-05-21 | Process for preparing compound iodine disinfectant |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN103988849A true CN103988849A (en) | 2014-08-20 |
Family
ID=51303393
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410229072.3A Pending CN103988849A (en) | 2014-05-21 | 2014-05-21 | Process for preparing compound iodine disinfectant |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103988849A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106581051A (en) * | 2016-11-08 | 2017-04-26 | 太原市诚诚科技有限公司 | Nano microemulsion iodine and preparation method thereof |
| CN111249373A (en) * | 2020-03-04 | 2020-06-09 | 刘志强 | A disinfectant liquid containing lignum Aquilariae Resinatum component and its preparation method |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1131535A (en) * | 1995-03-22 | 1996-09-25 | 李宏伟 | Multifunctional vaginal sponge |
| CN1593453A (en) * | 2003-09-10 | 2005-03-16 | 北京亚科希药物研究所 | Sterilizing and bacteria inhibiting pharmaceutical composition and its formulation and preparation process |
-
2014
- 2014-05-21 CN CN201410229072.3A patent/CN103988849A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1131535A (en) * | 1995-03-22 | 1996-09-25 | 李宏伟 | Multifunctional vaginal sponge |
| CN1593453A (en) * | 2003-09-10 | 2005-03-16 | 北京亚科希药物研究所 | Sterilizing and bacteria inhibiting pharmaceutical composition and its formulation and preparation process |
Non-Patent Citations (2)
| Title |
|---|
| 徐丹，浦金辉，郭苗苗，等: "《氯己定碘消毒剂的研究与临场应用进展》", 《医学导报》 * |
| 薛广波: "《现代消毒学》", 31 July 2002, 人民军医出版社 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106581051A (en) * | 2016-11-08 | 2017-04-26 | 太原市诚诚科技有限公司 | Nano microemulsion iodine and preparation method thereof |
| CN111249373A (en) * | 2020-03-04 | 2020-06-09 | 刘志强 | A disinfectant liquid containing lignum Aquilariae Resinatum component and its preparation method |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C12 | Rejection of a patent application after its publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20140820 |