CN103978675B - A kind of medical material surface modification system and method thereof - Google Patents
A kind of medical material surface modification system and method thereof Download PDFInfo
- Publication number
- CN103978675B CN103978675B CN201410239780.5A CN201410239780A CN103978675B CN 103978675 B CN103978675 B CN 103978675B CN 201410239780 A CN201410239780 A CN 201410239780A CN 103978675 B CN103978675 B CN 103978675B
- Authority
- CN
- China
- Prior art keywords
- control
- voltage
- gas
- motor
- plasma excitation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 238000000034 method Methods 0.000 title claims abstract description 41
- 230000004048 modification Effects 0.000 title claims abstract description 23
- 238000012986 modification Methods 0.000 title claims abstract description 23
- 239000012567 medical material Substances 0.000 title claims abstract description 22
- 230000005284 excitation Effects 0.000 claims abstract description 28
- 230000008569 process Effects 0.000 claims abstract description 21
- 230000001276 controlling effect Effects 0.000 claims description 26
- 238000009413 insulation Methods 0.000 claims description 18
- 230000004888 barrier function Effects 0.000 claims description 16
- 210000003437 trachea Anatomy 0.000 claims description 9
- 238000006073 displacement reaction Methods 0.000 claims description 8
- 230000007246 mechanism Effects 0.000 claims description 6
- 239000012620 biological material Substances 0.000 claims description 4
- 238000013507 mapping Methods 0.000 claims description 4
- 230000001105 regulatory effect Effects 0.000 claims description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 3
- 230000004308 accommodation Effects 0.000 claims description 2
- 239000000835 fiber Substances 0.000 claims description 2
- 238000002715 modification method Methods 0.000 claims description 2
- 238000000926 separation method Methods 0.000 claims description 2
- 230000001360 synchronised effect Effects 0.000 claims description 2
- 239000000463 material Substances 0.000 abstract description 37
- 238000005516 engineering process Methods 0.000 abstract description 5
- 239000007789 gas Substances 0.000 description 45
- 238000012545 processing Methods 0.000 description 7
- 230000003993 interaction Effects 0.000 description 6
- RVTZCBVAJQQJTK-UHFFFAOYSA-N oxygen(2-);zirconium(4+) Chemical compound [O-2].[O-2].[Zr+4] RVTZCBVAJQQJTK-UHFFFAOYSA-N 0.000 description 5
- 239000000758 substrate Substances 0.000 description 5
- 238000004381 surface treatment Methods 0.000 description 5
- 239000010409 thin film Substances 0.000 description 5
- 229910001928 zirconium oxide Inorganic materials 0.000 description 5
- 238000006243 chemical reaction Methods 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 239000000178 monomer Substances 0.000 description 4
- 238000006116 polymerization reaction Methods 0.000 description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- 238000010586 diagram Methods 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- MCMNRKCIXSYSNV-UHFFFAOYSA-N Zirconium dioxide Chemical compound O=[Zr]=O MCMNRKCIXSYSNV-UHFFFAOYSA-N 0.000 description 2
- 230000005281 excited state Effects 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 239000001307 helium Substances 0.000 description 2
- 229910052734 helium Inorganic materials 0.000 description 2
- SWQJXJOGLNCZEY-UHFFFAOYSA-N helium atom Chemical compound [He] SWQJXJOGLNCZEY-UHFFFAOYSA-N 0.000 description 2
- 239000011159 matrix material Substances 0.000 description 2
- 230000005855 radiation Effects 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 208000035985 Body Odor Diseases 0.000 description 1
- 206010055000 Bromhidrosis Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 206010070834 Sensitisation Diseases 0.000 description 1
- 208000007536 Thrombosis Diseases 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 239000004568 cement Substances 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 230000005495 cold plasma Effects 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 229910052571 earthenware Inorganic materials 0.000 description 1
- 230000005611 electricity Effects 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 238000010559 graft polymerization reaction Methods 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 229910001872 inorganic gas Inorganic materials 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 229910052756 noble gas Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 230000007096 poisonous effect Effects 0.000 description 1
- 230000008313 sensitization Effects 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000006557 surface reaction Methods 0.000 description 1
- 238000012876 topography Methods 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 238000012549 training Methods 0.000 description 1
- 230000007306 turnover Effects 0.000 description 1
- 238000007704 wet chemistry method Methods 0.000 description 1
Landscapes
- Plasma Technology (AREA)
Abstract
nullA kind of medical material surface modification system and method thereof belong to material surface modifying technology field，It is characterized in that by the source of the gas subsystem of available use、Plasma excitation voltage and frequency、Upper/lower electrode spacing all can be with working gas adjustable electric discharge work chamber subsystem and based on microprocessor upper、Bottom electrode spacing、Object stage is sent into、Plasma excitation voltage、The motor-driven of FREQUENCY CONTROL controls subsystem and collectively constitutes，Correspondingly propose a set of based on programme controlled method of modifying able to programme，The present invention is applicable to the pending medical material of different-thickness，Working gas can be selected by material character and process requirement、Also modification time and discharge parameter can be selected by material thickness，Utilize dielectric sheet to avoid the electrode pollution to material simultaneously，Vacuum system is instead of with the gas flow equalization room in electric discharge work chamber，Simplify working procedure，Save equipment cost，All achieve operation automatization.
Description
Technical field
The present invention relates to a kind of medical material surface modifying method and device, a kind of utilize uniform Jie produced under atmospheric pressure
Matter barrier discharge low-temperature plasma changes the method and device of the surface property of medical material.
Background technology
Biomaterial for medical purpose long-term with human contact time, it is necessary to fully meet and the compatibility of biological environment, i.e. organism not with
Any toxicity of generation, sensitization, inflammation, the bad biological respinse such as thrombosis.These both depend on material surface and biological environment
Interaction.Thus, effectively control and improve the surface nature of biomaterial, be to improve and promote material surface and organism
Between the critical path of the disadvantageous interaction that favorably interacts, suppresses, this is also that current medical material is studied at focus.
Affect the interaction between material and organism because of have the composition of biomaterial surface, surface topography, surface energy state,
Parent's (dredging) factor such as aqueous, surface charge.
At present, by material surface is processed the common method reaching to improve material surface performance have wet chemical process, light
The radiation of chemical Treatment, ultraviolet and Cement Composite Treated by Plasma etc..Wherein many some poisonous changes of use in wet chemical practice process
Learn reagent, not only serious environment pollution, human body is also had harm greatly.And photochemical method and ultraviolet radiation method etc. process skill
Art is limited by ray energy, and its treatment effect relatively can control.Cold-plasma surfaces treated technology is to material surface in contrast
The most hundreds of angstroms of depth of interaction, do not interfere with the character of matrix material, and variously-shaped material surface can be processed, have
The advantages such as technique is simple, easy and simple to handle, easily controllable, pollution-free, therefore lower temperature plasma technology is ideal medical
Material surface modifying technology.
Plasma is the gaseous material of a kind of part or all of ionization, containing metastable state and the atom of excited state, molecule, ion
On particle, surface reaction can be produced with material surface interactions, make surface occur physicochemical change to realize surface modification.
Plasma surface modification has three types, is plasma surface treatment, plasma surface polymerization and plasma respectively
Surface grafting.Material is processed by the plasma that plasma surface treatment mainly produces with the inorganic gas of non-polymerization.
(" plasma surface processor of multi-capacity coupled radio-frequency " as disclosed in domestic applications number 200510126484.5) be
In vacuum chamber noble gas discharge under the effect of radio frequency power source generation plasma, excited state gas molecule be positioned over radio frequency
Material surface interactions on electrode, makes material surface realize the effect of sterilization and surface modification.But in being embodied as,
Owing to the introducing of vacuum system makes operating process the most loaded down with trivial details, and exposed radio-frequency electrode can be to putting in specific implementation process
Electrical environment pollutes, and the radio frequency source in practice used electric discharge also has higher parameter and load matched requirement.Plasma
Surface aggregate is generally also under radio frequency or microwave excitation source forcing, to organic gas monomer plasma so that it is produce all kinds of
Group, between these active groups and carries out additive reaction between active group monomer and forms polymeric membrane thus reach material modification
Purpose.The process of plasma surface glycerol polymerization is that material surface plasma treated generation active group forms activity
Center, contacts trigger monomer and carries out graft polymerization reaction (such as domestic applications number with matrix surface with gas phase or liquid monomer
It is " a kind of macromolecule material surface modification method of plasma processing " 201110317878.4 open).
The application plasma technique of report carries out surface modification to medical macromolecular materials at present, the most still concentrates on vacuum system
Low pressure glow discharge plasma technique in system, " training for cell as disclosed in interior domestic applications number 200710026875.9
The process for treating surface of the macromolecular material supported " it is the cell culture container of finished product to be put in plasma processor, in vacuum
Or under negative pressure state, introduce oxygen, nitrogen or other plasma gas, discharge under suitable process conditions, cultivate at cell
Inner surface of container forms plasmasphere, thus improves the biocompatibility of macromolecular material.The enforcement weak point of this process
It is, remains a need for carrying out in vacuum system in whole processing procedure, the existence of vacuum chamber, on the one hand make the manufacture of equipment
It is greatly increased with maintenance cost, on the other hand also limit the physical dimension of processed workpiece, thus significantly limit its application
Other discharge gas could be changed after whole processing procedure terminates after being passed through discharge gas in scope, and vacuum system, thus only
Single plasma polymerization process or plasma surface treatment process can be realized, the later stage also need to be aided with other courses of reaction with
Reach to realize the biocompatibility of material.
" system of processing thin-film material surface using bi-medium to block electric discharge " disclosed in domestic applications 200710090033.X its spy
Levying and be, in atmosphere by the many groups of metal tube electrodes being coated with by glass tubing or earthenware, when electric discharge is carried out, electrode self also exists
Rotate, the purpose of surface modification can be reached in-between the electrodes through thin-film material.This processing system is in specific implementation process
Realize more gentle uniform quasi-glow discharge, can only discharge under being intended for the minimum electrode gap that thin film passes and to produce plasma
Body, significantly limit the volume being available for processing material, simultaneously need to motor or thin-film material band moving electrode rotation, it is to avoid electrode
Local heating uneven.The method can only be confined to the surface-treatment applications of part thin-film material.
Summary of the invention
It is an object of the invention to provide a kind of medical material surface modifying method and device, use this device, by regulation and control work gas
Bromhidrosis road, it is possible to achieve to freely switching of the reactions such as the surface modification of medical material and surface aggregate grafting.
Present system is characterised by, contains: source of the gas subsystem, electric discharge work chamber subsystem and control subsystem, wherein:
Source of the gas subsystem 1, contains: air source device pipeline, mixed gas tank and trachea, wherein:
Air source device pipeline 11, in order to provide the single channel being easy to freely switch or the working gas of multichannel mixing, described in each road
Steam line is formed by needle-valve 111, air relief valve 112 and gas cylinder 113 concatenation switched for controlling described working gas,
Mixed gas tank 12, air inlet is connected by trachea with the gas outlet of needle-valve each described 111, giving vent to anger of described mixed gas tank 12
Mouth is connected by trachea with the effusion meter 132 in the air inlet 1511 at the casing back side, casing successively, described effusion meter 132
Gas outlet occurs the air inlet 142 of the gas flow equalization room 1510 in operating mechanism to communicate by trachea with plasma, in order to described
Gas discharge produces plasma,
Electric discharge work chamber subsystem, is that described plasma occurs operating mechanism, contains: top fixed-wing 151, on
Electrode 152, sliding rail 153, bottom electrode 154, output voltage are 1kV～30kV, frequency be 5kHz～16kHz etc. from
Daughter excitation power supply 155 and insulation barrier 156, wherein:
It is that under 1mm～3mm, described in dielectric sheet 157, bottom electrode 154 passes through to lead that bottom electrode 154 upper surface closely posts thickness
Line is connected with described casing jointly with the low-pressure end of described plasma excitation power supply 155 and ground connection, described lower dielectric sheet 157
The left and right sides, be tightly embedded intp respectively in two corresponding described sliding rails 153, together constitute an object stage,
Upper electrode 152 lower surface is glued with the upper dielectric sheet 158 that thickness is 0.3mm～3mm, and described upper electrode 152 leads to
Cross wire to be connected with the high-pressure side of described plasma excitation power supply, the upper surface of upper electrode 152 and described top fixed-wing 151
Lower surface fixing be affixed,
Insulation barrier 16, arranged on left and right sides is respectively arranged with one piece, and the described insulation barrier in left side has described gas flow equalization in the horizontal direction
The air inlet 142 of room 1510, side insulation right baffle plate has array venthole, described left and right two pieces of insulation in the horizontal direction
Plate 16 is close to outside and the outside of described sliding rail of described top fixed-wing 151 from top to bottom along longitudinal direction,
The inner side of left and right two pieces of insulation barriers 1561,1562, the lower surface of upper dielectric sheet 158, lower dielectric sheet 157
Two sliding rails 1531,1532 of upper surface and left and right upper surface between space segment together constitute described gas
All flow chamber 1510, define an electric discharge work chamber,
Control subsystem, at least contain control motor 17 and microprocessor 18, wherein:
Control motor, contain: first controls motor 171 and second controls motor 172, wherein:
First control motor 171, output shaft is coaxially connected with the leading screw 159 being arranged on described top fixed-wing 151 upper surface,
For controlling the gap between described upper dielectric sheet 158 and lower dielectric sheet 157, it is achieved between vertical between upper/lower electrode
Away from control, range of accommodation is 3mm～10mm,
Second control motor 172, by output shaft synchronous control about two described sliding rails 1531,1532 level slide,
Realize described object stage and pass in and out the control of described electric discharge work chamber,
Microprocessor 18, presets the process time, and unit is the second, and the upper/lower electrode described in flow-control scope control,
It is provided with:
For the first described control motor 171, preset:
Described upper electrode (152), the initial separation between bottom electrode (154)
Mapping table between described working gas classification leading screw 159 Bit andits control voltage
Control electrode 172 for described second, preset:
The initial position of described sliding rail 153 and range thereof,
For described plasma excitation power supply 155, preset:
Described working gas classification plasma excitation voltage processes the mapping table of time three
Described microprocessor 18 is additionally provided with following input:
The described first control voltage input end controlling motor 171 and the upper and lower displacement amount feedback input end of described leading screw 159,
The described second control voltage input end controlling motor 172 and the horizontal displacement feed back input of described sliding rail 153
End,
The voltage controling value input of described plasma excitation power supply 155 and FREQUENCY CONTROL value input,
Described microprocessor 18 is additionally provided with following outfan:
The described first magnitude of voltage outfan controlling motor 171, when the upper and lower displacement amount of described leading screw 159 reaches setting value,
Described output voltage is zero,
The described second magnitude of voltage outfan controlling motor 172, when the horizontal displacement of described sliding rail 153 reaches setting value
Time, described output voltage is zero,
Set the plasma excitation magnitude of voltage outfan of working gas and frequency values outfan, arrive the described process time, then two
The output valve of individual described voltage and frequency is zero simultaneously.
It is provided with: front panel, rear board and left and right sides panel, wherein:
Front panel 21 is provided with: work hatch door 211 and control panel 212:
Work hatch door 211, is positioned at described object stage front end,
On control panel 212, it is provided with:
The digital display meter head 213 of the output voltage values of described plasma excitation power supply 155 and the frequency values digital display meter of this output voltage
214, and corresponding voltage-regulation button 215 and frequency regulation button 216, wherein: described voltage-regulation button 215 is defeated
Going out end to be connected with the plasma excitation voltage controling value input on described microprocessor 18, described frequency regulation button 216 is defeated
Go out end to be connected with corresponding described FREQUENCY CONTROL value input,
The described first control voltage-regulation button 217 controlling motor 171, described the on outfan and described microprocessor 18
The one control voltage input end controlling motor 171 is connected,
The described second control voltage-regulation button 218 controlling motor 172, described the on outfan and described microprocessor 18
The two control voltage input ends controlling motor 172 are connected,
Flow regulation button (219) is used for regulating the flow of effusion meter (132), and is shown by effusion meter dial plate (221),
LCDs 222, input is connected with the outfan of the CCD camera being fixed on described front panel 21 back side, described CCD
The fiber optic camera head of camera faces at described electric discharge work chamber inside in being inserted into any one piece of described insulation barrier 156,
Left and right sides panel 231, has louvre 2311 on 232,
On rear board 24, it is provided with: on and off switch 241, air inlet 1511 and fan outlet 242.
A kind of medical material surface modifying method, it is characterised in that contain following steps successively:
Step (1), turns on the power switch 241, by the described first control voltage-regulation button 217 controlling motor 171, adjusts
Save the described upper dielectric sheet 158 spacing with described object stage to adapt to the size of pending medical material；
Step (2), pulls out described object stage, institute by the described second control voltage-regulation button 218 controlling motor 172
State pending medical material to be positioned on described object stage, more described object stage is sent in electric discharge work chamber；
Step (3), is passed through, in described electric discharge work chamber, the working gas specified；
Step (4), regulates described plasma excitation voltage-regulation button 215 and frequency regulation button 216, input and work gas
Body corresponding plasma excitation voltage and frequency values, carry out surface modification to described pending medical material；
Step (5), after arriving the process time set, turns off air relief valve corresponding to working gas and needle-valve, disconnects working gas,
Pull-out object stage, takes out the described medical material handled well, after making described object stage and leading screw reset, turns off the power switch.
Advantages of the present invention is embodied in (1) plasma generator device and realizes automatically controlling, can pending for different-thickness
Material is automatically adjusted out suitable discharge space, is possible not only to effective and reasonable utilize working gas, also can the pending material of reasonably optimizing
The electric discharge modification time of material and discharge parameter；(2) pending material is placed in the middle of two insulating medium layers, it is to avoid electrode is to material
Pollution, the most effectively extend the working life of reaction unit simultaneously；(3) work gas is provided by gas flow equalization room to work chamber
Body, can make working gas be uniformly distributed in work chamber, greatly improves plasma uniform that working gas electric discharge produces
Property；(4) work chamber eliminates the parcel of vacuum system, greatly simplify the working procedure of plasma surface modification, greatly
The cost reducing plasma surface modification equipment；(5) automatization of device is farthest achieved, including work chamber
The automatic control regulation of interior discharge space, the automatic control regulation of object stage, so that the modifying process of material more controllable precise, reduce
The operation easier of plasma surface modification device.
Accompanying drawing explanation
Fig. 1 is the structural representation of the embodiment of the present invention；
Fig. 2 is that the plasma of the embodiment of the present invention occurs operating mechanism's schematic diagram；
Fig. 3 is the plasma generator structure schematic diagram of the embodiment of the present invention；
Fig. 4 is the casing front view of the embodiment of the present invention；
Fig. 5 is the casing rear view of the embodiment of the present invention；
Fig. 6 is embodiment hydrophilically modified contact angle front and back contrast photo: before (a) surface modification, after (b) surface modification；
Fig. 7 is for controlling subsystem block diagram.
Detailed description of the invention
Below in conjunction with the accompanying drawings embodiments of the invention are described in detail, so that advantages and features of the invention can be easier to by this
Skilled person understands, thus protection scope of the present invention is made apparent defining.
Embodiment: substrate surface modification cultivated by medical zirconium oxide
Work base material uses medical zirconium oxide to cultivate substrate, it is therefore an objective to improve the hydrophilicity on surface, opens and is positioned at the casing back side
On and off switch 241, regulates upper electrode 152 and absolutely by self-control button 217 on the control panel 212 of front panel 21 right-hand member
Distance between edge layer 158 and lower stage is 3mm；Work bunker is removed by the self-control button 218 on control panel 212
Thing platform, is positioned over medical zirconium oxide cultivation substrate on object stage, sends object stage back to work by the self-control button on control panel
Make in cabin；Helium it is passed through in work chamber；Voltage knob 215 on regulation control panel, input service voltage 4.4kV discharges
Produce plasma, medical zirconium oxide is cultivated substrate surface treatment 30s；Regulation voltage knob 215, closes input voltage,
Disconnect working gas, export object stage, take out the medical zirconium oxide handled well and cultivate substrate, object stage is sent back in work chamber,
Turn off the power switch, complete whole processing procedure.
It is contained in different gas cylinders 113 refering to the working gas that Fig. 1 is different, gas cylinder is provided with air relief valve 112, air relief valve
The outlet port of 112 is connected with mixed gas tank 12 by gas pipeline, and single channel steam line is provided with the needle-valve controlling gas break-make
111 are used for free switch operating gas；Being connected with the air inlet 131 at the casing back side in mixed gas tank, air inlet 131 passes through gas
Pipe is connected with the effusion meter 132 in casing, and the effusion meter 132 in casing is occurred in operating mechanism with plasma by trachea
Gas flow equalization room 141 1 lateral aperture is that the air inlet 142 of 8mm is connected；It is 11mm array venthole by aperture again
For electric discharge generation plasma in 122 uniform inflow work chambers.
Refering to Fig. 1 to Fig. 5, the control function of front panel is controlled by the programmable control system 18 in casing, upper electrode 152 and
Upper insulating barrier 158 is fixed on top fixed-wing 151 times, and fixed-wing 151 is provided with two leading screws 159, and control system 18 is led to
Cross and control the motor 171 upper electrode 152 of realization and the vertical upgrade function of upper insulating barrier 158；Object stage is by the sliding rail of both sides
153 and lower dielectric sheet 157 form, sliding rail 153 is connected with motor 172, control system 18 by control electricity
The rotation of machine 172 realizes object stage turnover work chamber.
Upper surface refering to Fig. 3 plasma generator bottom electrode 154 is closely affixed with lower dielectric sheet 157 lower surface, under
Electrode is connected with the high-pressure stage of plasma excitation power supply module 155 by high-voltage conducting wires, upper electrode 152 lower surface and upper insulation
Dielectric layer 158 closely attaches mutually, and upper electrode is connected with plasma excitation power supply module 155 ground electrode by wire, while with
Casing is connected ground connection, and the insulation barrier 156 of generator both sides and gas flow equalization room 141 and upper insulating barrier and lower insulation plate are common
Constitute electric discharge work chamber 15.
It is provided with work chamber hatch door 211, before work chamber hatch door is fixed on object stage refering on the left of Fig. 4 and Fig. 5 casing front panel 21
End, be provided with on the right side of front panel 21 automatically can control panel, automatic control panel has the defeated of plasma excitation voltage source 155
Go out the digital display meter head 213 of magnitude of voltage, the frequency values digital display meter head 214 of this output voltage and corresponding voltage-regulation button 215
Control the control voltage-regulation button 217 of motor 171 with frequency regulation button 216, LCDs 222, first, flow is adjusted
Joint knob 219 is for controlling the input flow rate of effusion meter；The casing left and right sides has louvre 2311；Casing rear board 24 times
End is provided with on and off switch 241, air inlet 131 and fan mouth 242.
It is 78 degree refering to the medical zirconia material of Fig. 6 dielectric sheet 157 water contact angle before modified under putting into object stage, warp
Helium is under 4.4kV running voltage encourages after discharge process 30s, and the water contact angle recording this material surface is 32 degree.
Three detection data of embodiment hydrophilicity
The above, the only detailed description of the invention of the present invention, but the scope of protection of the invention is not limited thereto, and any familiar
Those skilled in the art in the technical scope that disclosed herein, the variations and alternatives expected without creative work, all
Should contain within protection scope of the present invention.Therefore, the protection domain that protection scope of the present invention should be limited with claims
It is as the criterion.
Claims (3)
1. a medical material surface modification system, it is characterised in that contain: source of the gas subsystem, electric discharge work chamber subsystem
With control subsystem, wherein:
Source of the gas subsystem (1), contains: air source device pipeline, mixed gas tank and trachea, wherein:
Air source device pipeline (11), in order to provide the single channel being easy to freely switch or the working gas of multichannel mixing, each road institute
The steam line stated is by for controlling the needle-valve (111) of described working gas switching, air relief valve (112) and gas cylinder (113) string
Connect and form,
Mixed gas tank (12), air inlet is connected by trachea with the gas outlet of needle-valve each described (111), described mixed gas tank (12)
Gas outlet (121) be connected by trachea with the effusion meter (132) in the air inlet (1511) at the casing back side, casing successively
Logical, there is the gas flow equalization room (1510) in operating mechanism by trachea with plasma in the gas outlet of described effusion meter (132)
Air inlet (142) communicate, in order to described gas discharge produce plasma,
Electric discharge work chamber subsystem, is that a described plasma occurs operating mechanism, contains: top fixed-wing (151),
Upper electrode (152), sliding rail (153), bottom electrode (154), output voltage are 1kV～30kV, frequency is 5kHz～16
KHz plasma excitation power supply (155) and insulation barrier (156), wherein:
It is dielectric sheet (157) under 1mm～3mm that bottom electrode (154) upper surface closely posts thickness, described bottom electrode
(154) jointly it is connected with described casing with the low-pressure end of described plasma excitation power supply (155) and ground connection by wire,
The left and right sides of described lower dielectric sheet (157) is tightly embedded intp respectively two corresponding described sliding rails (153)
In, together constitute an object stage,
Upper electrode (152) lower surface is glued with the upper dielectric sheet (158) that thickness is 0.3mm～3mm, described in power on
Pole (152) is connected with the high-pressure side of described plasma excitation power supply by wire, the upper surface of upper electrode (152) and institute
State that the lower surface of top fixed-wing (151) is fixing to be affixed,
Insulation barrier (156), arranged on left and right sides is respectively arranged with one piece, and the described insulation barrier in left side has described gas in the horizontal direction
The air inlet (142) of the equal flow chamber of body (1510), side insulation right baffle plate has array venthole in the horizontal direction, described
Left and right two pieces of insulation barriers (1561,1562) along be longitudinally close to from top to bottom described top fixed-wing (151) outside and
The outside of described sliding rail,
The inner side of left and right two pieces of insulation barriers (1561,1562), the lower surface of upper dielectric sheet (158), lower insulation are situated between
The common structure of space segment between the upper surface of two sliding rails (1531,1532) of upper surface and left and right of matter sheet (157)
Become described gas flow equalization room (1510), define an electric discharge work chamber,
Control subsystem, at least contain control motor and microprocessor (18), wherein:
Control motor, contain: first controls motor (171) and second controls motor (172), wherein:
First control motor (171), output shaft and the leading screw (159) being arranged on described top fixed-wing (151) upper surface are same
Axle connects, and is used for controlling the gap between described upper dielectric sheet (158) and lower dielectric sheet (157), it is achieved on
The control of vertical interval between bottom electrode, range of accommodation is 3mm～10mm,
Second controls motor (172), by output shaft synchronous control about the water of two described sliding rails (1531,1532)
It is smooth dynamic, it is achieved described object stage passes in and out the control of described electric discharge work chamber,
Microprocessor (18), presets the process time, and unit is the second, and the upper/lower electrode described in flow-control scope control,
It is provided with:
For the first described control motor (171), preset:
Described upper electrode (152), the initial separation between bottom electrode (154),
Mapping table between described working gas classification leading screw (159) Bit andits control voltage
Control motor (172) for described second, preset:
The initial position of described sliding rail (153) and range thereof,
For described plasma excitation power supply (155), preset:
Described working gas classification plasma excitation voltage processes the mapping table of time three
Described microprocessor (18) is additionally provided with following input:
The upper and lower displacement amount feedback of the described first control voltage input end controlling motor (171) and described leading screw (159)
Input,
The described second control voltage input end controlling motor (172) and the horizontal displacement of described sliding rail (153)
Feedback input end,
The voltage controling value input of described plasma excitation power supply (155) and FREQUENCY CONTROL value input,
Described microprocessor (18) is additionally provided with following outfan:
The described first magnitude of voltage outfan controlling motor (171), when the upper and lower displacement amount of described leading screw (159) reaches to set
During definite value, described output voltage is zero,
The described second magnitude of voltage outfan controlling motor (172), when the horizontal displacement of described sliding rail (153) reaches
During to setting value, described output voltage is zero,
Set plasma excitation magnitude of voltage outfan and the frequency values outfan of working gas, arrive the described process time, then
The output valve of two described voltages and frequency is zero simultaneously.
A kind of medical material surface modification system the most according to claim 1, it is characterised in that be provided with: front panel,
Rear board and left and right sides panel, wherein:
Front panel (21) is provided with: work hatch door (211) and control panel (212):
Work hatch door (211), is positioned at described object stage front end,
On control panel (212), it is provided with:
The digital display meter head (213) of the output voltage values of described plasma excitation power supply (155) and the frequency of this output voltage
Value digital display meter head (214), and voltage-regulation button (215) and frequency regulation button (216) accordingly, wherein: described
Plasma excitation voltage controling value input phase on voltage-regulation button (215) outfan and described microprocessor (18)
Even, described frequency regulation button (216) outfan is connected with corresponding described FREQUENCY CONTROL value input,
Described first control voltage-regulation button (217) controlling motor (171), outfan and described microprocessor (18)
On described first control motor (171) control voltage input end be connected,
Described second control voltage-regulation button (218) controlling motor (172), outfan and described microprocessor (18)
On described second control motor (172) control voltage input end be connected,
Flow regulation button (219) is used for regulating the flow of effusion meter (132), and is shown by effusion meter dial plate (221),
LCDs (222), input is connected with the outfan of the CCD camera being fixed on described front panel (21) back side,
The fiber optic camera head of described CCD camera faces described electric discharge work in being inserted into any one piece of described insulation barrier (156)
Make at inside, cabin,
Louvre (2311) is had on left and right sides panel (231,232),
On rear board (24), it is provided with: on and off switch (241), air inlet (1511) and fan outlet (242).
A kind of medical material surface modification system the most according to claim 1 and the Biomaterials Modification method that proposes, its
It is characterised by, contains following steps successively:
Step (1), turns on the power switch (241), by the described first control voltage-regulation button controlling motor (171)
(217) the described upper dielectric sheet (158) spacing with described object stage, is regulated to adapt to the size of pending medical material；
Step (2), pulls out described loading by the described second control voltage-regulation button (218) controlling motor (172)
Platform, is positioned over described pending medical material on described object stage, more described object stage is sent in electric discharge work chamber；
Step (3), is passed through, in described electric discharge work chamber, the working gas specified；
Step (4), regulates described plasma excitation voltage-regulation button (215) and frequency regulation button (216), input
Plasma excitation voltage corresponding with working gas and frequency values, carry out surface modification to described pending medical material；
Step (5), after arriving the process time set, turns off air relief valve corresponding to working gas and needle-valve, disconnects work gas
Body, pulls out object stage, takes out the described medical material handled well, after making described object stage and leading screw reset, closes power supply and opens
Close.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410239780.5A CN103978675B (en) | 2014-05-30 | 2014-05-30 | A kind of medical material surface modification system and method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410239780.5A CN103978675B (en) | 2014-05-30 | 2014-05-30 | A kind of medical material surface modification system and method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103978675A CN103978675A (en) | 2014-08-13 |
| CN103978675B true CN103978675B (en) | 2016-10-05 |
Family
ID=51270960
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410239780.5A Active CN103978675B (en) | 2014-05-30 | 2014-05-30 | A kind of medical material surface modification system and method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103978675B (en) |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5953541A (en) * | 1982-09-20 | 1984-03-28 | Shin Etsu Chem Co Ltd | Surface improvement of organic polymer formed product |
| CN1981876A (en) * | 2005-12-14 | 2007-06-20 | 中国科学院光电研究院 | Plasma surface processor of multi-capacity coupled radio-frequency |
| CN101041724A (en) * | 2007-02-12 | 2007-09-26 | 袁建华 | Surface treatment technique of macromolecular material for cell culture |
| CN101277576A (en) * | 2007-03-26 | 2008-10-01 | 中国科学院光电研究院 | System for processing thin-film material surface using bi-medium to block electric discharge |
| CN103057133A (en) * | 2011-10-19 | 2013-04-24 | 苏州市奥普斯等离子体科技有限公司 | Treatment method and device for modification plasma on a high polymer material surface |
| CN204340200U (en) * | 2014-05-30 | 2015-05-20 | 北京振戎融通通信技术有限公司 | A kind of medical material surface modification system |
-
2014
- 2014-05-30 CN CN201410239780.5A patent/CN103978675B/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN103978675A (en) | 2014-08-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN204340200U (en) | A kind of medical material surface modification system | |
| CN203694182U (en) | Ultraviolet sterilization equipment | |
| US20150327430A1 (en) | Cold plasma seed treatment device | |
| CN106028615B (en) | Large-area low-temperature plasma generating device | |
| US7898160B2 (en) | Method and apparatus for modifying object with electrons generated from cold cathode electron emitter | |
| CN105199133B (en) | A kind of big culture dish atmospheric low-temperature plasma processing unit and its operating method | |
| CN108329679A (en) | A kind of preparation method of solvent-free graphene electric-heating thin film | |
| CN103978675B (en) | A kind of medical material surface modification system and method thereof | |
| CN104862651A (en) | Device and method for preparing hydrogenated silicon film | |
| WO2022227235A1 (en) | Plasma sterilization device, preparation method for sterilization gas, and sterilization method | |
| CN102497720B (en) | Atmospheric pressure optical plasma brush-type device and electric discharge method thereof | |
| CN205115353U (en) | Big culture dish ordinary pressure low temperature plasma processing apparatus | |
| KR102149432B1 (en) | APPARATUS FOR GENERATING NOx GAS AND CONTROLLING METHOD THEREOF | |
| CN110092356A (en) | The surface dielectric barrier discharge ozone generating-device and method of gas flowing control | |
| CN206140892U (en) | Atmosphere ordinary pressure low temperature plasma plastic sheeting for farm use treatment facility | |
| US20210196340A1 (en) | Cold plasma generating device with positional control | |
| CN209289790U (en) | A kind of atmos low-temperature plasma sheet film processing equipment | |
| CN109874220A (en) | A kind of metal cup atmospheric low-temperature plasma processing unit and application method | |
| CN209423673U (en) | A kind of small-size multifunction experiment porch | |
| CN113966804A (en) | Food sterilization device based on plasma technology | |
| CN113154610A (en) | Air purifier with temperature adjusting function | |
| CN102847420A (en) | Waste gas processing device | |
| CN110451700B (en) | Ultraviolet light-emitting diode-non-thermal plasma combined disinfection device and method | |
| CN110036717A (en) | A kind of dielectric barrier discharge device for treatment of seeds | |
| CN218901434U (en) | Preparation facilities of high-efficient evaporation membrane |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant |