CN103977075A - Traditional Chinese medicine sticking preparation for preventing and curing osteoporosis - Google Patents
Traditional Chinese medicine sticking preparation for preventing and curing osteoporosis Download PDFInfo
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- CN103977075A CN103977075A CN201410184948.7A CN201410184948A CN103977075A CN 103977075 A CN103977075 A CN 103977075A CN 201410184948 A CN201410184948 A CN 201410184948A CN 103977075 A CN103977075 A CN 103977075A
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Abstract
The invention discloses a traditional Chinese medicine sticking preparation for preventing and curing osteoporosis. A traditional plaster is used as a carrier, and active components in the preparation are prepared from the following raw materials according to the following weight ratio: rhizoma cibotii: epimeddium: cortex cinnamomi=2:2:1. According to a making method of the preparation, the above active components are extracted; and after the extracted active components are mixed with other auxiliary agents, the plaster is prepared is prepared by a common method. The auxiliary agents used are also common auxiliary agents in present plaster production. The plaster for external use is selected as the preparation and has the following advantages: 1, significant curative effect and fast effectiveness; 2, wide indications and convenient use; and 3, safe usage and no toxic or side effect.
Description
Technical field
The invention belongs to technical field of Chinese medicines, particularly relate to a kind of for preventing and treating osteoporotic Chinese medicine application preparation.
Background technology
Along with socioeconomic development and growth in the living standard, China has progressed into aging society, and osteoporotic prevalence increases year by year.The prevalence women of China's senile osteoporosis is 90%, and male is 61%, occupies the 6th of commonly encountered diseases in the whole world.The World Health Organization (WHO) thinks that osteoporosis is after cardiovascular disease, second largest lethal health care problem.The osteodynia that this disease causes, osteopathia are even fractured and have seriously been reduced the quality of life of middle-aged and elderly people, and have greatly increased patient's medical expense, thereby enjoy medical treatment and scientific research personnel's attention.In recent years, osteoporotic etiology and pathogenetic research are gradually goed deep into.At present Western medicine is more for the treatment of bone resorption, mainly contains the medicines such as alternative medicine, Diphosphonate, calcitonin of hormone; And Chinese medicine has had certain progress to the research of the mechanism research of osteoporosis and Therapeutic Method, Therapeutic Method substantially can be divided into the kidney invigorating warming YANG, nourishing YIN for benefiting the kidney, invigorating the spleen and replenishing QI, qi and blood tonifying, strengthening the tendons and bones, promoting blood circulation and stopping pain etc., and centering is senile and menopause patient there is good curative effect.The effective Chinese medicine for the treatment of osteoporosis disease is few at present, and the dependency of Western medicine toxic side effect and long-term taking, and late result is not certainly.
Osteoporosis is one of clinical orthopaedics commonly encountered diseases, and the research and development osteoporotic preparation for the treatment of and method are more and more at present, enjoys clinicist and research worker to pay close attention to, and has become study hotspot.1) oral medicine calcium preparation: this type of medicine all has a certain impact to gastrointestinal tract, few to local absorbtivity, excessive use easily causes calculus or hypercalcemia; 2) oral medicine vitamin D agent: the existing side effect of long-term taking--hypercalcemia, have a dependency again; 3) oral medicine Diphosphonate and injection medicine Diphosphonate: there is the effect of good control calcium loss, but have certain stimulation side reaction to produce to upper esophagus, and expensive; 4) injection medicine calcitonin and nasal spray medicine calcitonin: analgesic effect is better, its drawback of injection is that drug dependence is long in the skin time, easily produces irritated grade for side reaction, nasal spray absorbs weak person to nose should not be used.
Summary of the invention
The object of this invention is to provide a kind of effect remarkable, easy to use for preventing and treating osteoporotic Chinese medicine application preparation.
For this reason, the technical solution used in the present invention is such: for preventing and treating osteoporotic Chinese medicine application preparation, take traditional plaster as carrier, it is characterized in that: the raw material preparation that the effective ingredient in preparation is following weight ratio obtains: Rhizoma Cibotii: Herba Epimedii: Cortex Cinnamomi=2:2:1.
Manufacture method of the present invention is by described effective ingredient extraction, after mixing, by common method, makes plaster with other auxiliary agents.Auxiliary agent used is also the usual auxiliaries during existing plaster is produced.
In effective ingredient of the present invention, the bitter temperature of Herba Epimedii acrid in the mouth, returns Liver and kidney warp, cure mainly, and kidney-replenishing, bone and muscle strengthening, wind-damp dispelling,, cold extremities with aversion to cold soft for impotence due to deficiency of the kidney, premature ejacuation emission, waist knee joint flaccidity, and numb for arthralgia due to cold-dampnes or spasm of the limbs.Rhizoma Cibotii, bitter sweet temperature, returns Liver and kidney warp, cures mainly: invigorating the liver and kidney, except rheumatism, strong waist foot, sharp joint.Control lumbar and back pain, gonalgia flaccidity of the lower limbs, loses and drowns, frequent micturition, seminal emission, leucorrhea; Cortex Cinnamomi extremely hot in nature, acrid in the mouth, sweet.Return kidney, spleen, the heart, Liver Channel, cure mainly: mend fire supporing yang, let the fire back to its origin, dispersing cold for relieving pain, promoting blood circulation to restore menstrual flow.For sexual impotence, cold womb, trusted subordinate's cold type of pain, deficiency and coldness vomiting and diarrhoea, amenorrhea, dysmenorrhea, warming the meridian and promoting blood circulation.
The compatibility of above-mentioned medical material is such: monarch drug Herba Epimedii, invigorating the kidney and strengthening the bones, minister, with Rhizoma Cibotii the kidney invigorating, bone and muscle strengthening, is helped with Cortex Cinnamomi dredging collateral warming the meridian and activating blood circulation, all medicine phases 5, bring out the best in each other, deficiency of the kidney is mended, and meridians are led to, and skeleton is able to strong, thereby reach better, the calcium conversion skeletonization of faster conditioning human body the intensity of enhances skeletal.
Using method of the present invention is to stick every day once, and 8-12 hour, three months is a course for the treatment of.Stick in acupuncture points such as the gate of vitality, shen shu, san chiao shu, the Large Intestine Shu, Qihai, Guan Yuan, yao yang kuan, pang kuang shu, chi hai shus.
The present invention selects externally applied ointment as preparation, has advantages of as follows:
1, evident in efficacy, take effect rapidly.Plaster is treated to send out and is imposed on part, and the medicine in local organization is significantly higher than haemoconcentration, so play a role fully, rapidly, local efficacy is obviously better than oral medication, is applicable to very much inconvenient pill taker or is reluctant that pill taker uses;
2, indication is wide, easy to use.Do not need to be in hospital, as long as understand effect and the applicable card of conventional plaster, contraindication, patient just can buy medicine according to disease, by applying method and requirement, treats voluntarily;
3, use safety, have no side effect.Plaster therapy is for the local dispenser of patient's disease sites, little to the entire effect of human body, thereby has avoided the toxic and side effects of medicine to liver and other organs, therefore very safe and reliable.
The present invention, by adopting Chinese medicine application preparation to reach the effect of the kidney invigorating, warming the meridian, bone and muscle strengthening, is the osteoporotic Chinese herbs paste of a kind of effective control.
The specific embodiment
The making of embodiment mono-preparation
Get Rhizoma Cibotii 200g, Herba Epimedii 200g, Cortex Cinnamomi 100g, adds the alcoholic solution 3L of mass concentration 65%, carries out alcohol extraction extraction; Alcohol extraction twice, merges alcohol extract, filters, and filtrate is concentrated into 0.25 g/ml.The chitosan solution 50ml that adds mass concentration 1%, stirs, and in 40C water-bath, is incubated 5 minutes, standing 24 hours, filters.Filtrate adds Plumbum preparatium 100g, when being evaporated to relative density and being 1.2(55 ~ 60C) fluid extract, add Borneolum Syntheticum 5g, be then coated on base material, make patch.
Embodiment bis-clinical experiments
From former I type sufferers of osteoporosis face 120 examples of certain osteoporosis research centre of prevention and cure screening.Adopt the method for Random Design that 120 routine patients are divided into 2 groups, every group of each 60 examples.Take 6 months as a course for the treatment of, totally two courses for the treatment of.Treatment group: on the basis of Oral Calcium Preparations and Vit-D, regularly stick the plaster of embodiment mono-; Matched group: empty to group (simple oral calcium preparation and Vit-D).
Testing result
(1) variation of bone turnover marker before and after treatment
Note: with blank group and the front relatively * P<0.05 for the treatment of, * * P<0.01.
Therapeutic outcome shows: after treatment, each treatment group bone turnover marker all has reduction trend.Bone alkaline phosphatase, change of serum C rosslaps significantly decline.
(2), the variation of BMD before and after treatment
Note: with blank group and the front relatively * P<0.05 for the treatment of, * * P<0.01.
Result shows: before and after treatment, each treatment group bone density all has increase trend.With before treatment and blank group compare and all have significant difference.
(3), respectively organize comprehensive therapeutic effect analysis
Result shows: each treatment group comprehensive therapeutic effect with before treatment and blank group compare and all have significant difference.
Model case:
(1) patient, female, 84 years old, retirement, suffer from osteoporosis for many years, though because of oral osteosporosis resistant medicament effective for many years, larger to gastrointestinal tract, hepatic and renal function injure, the treatment of Gu Yuwo institute, give herbal application 3 months, pain symptom obviously alleviates, and BMD obviously raises, and symptom is obviously improved.
(2) patient, female, 68 years old, retirement, detects and is diagnosed as osteoporosis through borne densitometers, once once several hospitalizes, but symptom is not only without improving, increase the weight of gradually on the contrary, sometimes walk just very difficult, particularly whole body pain increases the weight of day by day, to our hospital, give Chinese medicine note applying treatment three months, its pain is obviously alleviated, can be own movable.
Claims (1)
1. for preventing and treating osteoporotic Chinese medicine application preparation, take traditional plaster as carrier, it is characterized in that: the raw material preparation that the effective ingredient in preparation is following weight ratio obtains: Rhizoma Cibotii: Herba Epimedii: Cortex Cinnamomi=2:2:1.
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CN201410184948.7A CN103977075A (en) | 2014-05-05 | 2014-05-05 | Traditional Chinese medicine sticking preparation for preventing and curing osteoporosis |
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Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1682786A (en) * | 2004-04-16 | 2005-10-19 | 高学廉 | Adhesive plaster |
CN101485726A (en) * | 2008-01-14 | 2009-07-22 | 浙江省新华医院 | Chinese medicine for osteoporosis and healing waistband |
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2014
- 2014-05-05 CN CN201410184948.7A patent/CN103977075A/en active Pending
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1682786A (en) * | 2004-04-16 | 2005-10-19 | 高学廉 | Adhesive plaster |
CN101485726A (en) * | 2008-01-14 | 2009-07-22 | 浙江省新华医院 | Chinese medicine for osteoporosis and healing waistband |
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Application publication date: 20140813 |