CN103976942A - Dental ulcer gel and preparation method thereof - Google Patents
Dental ulcer gel and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a dental ulcer gel and a preparation method thereof. The gel is prepared from the following components in parts by weight: 0.3-4 parts of polyvinyl alcohol, 0.2-2 parts of chitosan, 15-40 parts of water, 0.3-2 parts of glacial acetic acid, 0.5-4 parts of auxiliaries and 40-80 parts of absolute ethyl alcohol. According to the dental ulcer gel, the gel material is screened and optimized, the preparation process is optimized and regulated, the obtained product has high stability, a film can be formed quickly, and the antibacterial effect is good; the materials of the dental ulcer gel are wide in sources and low in cost, the preparation process is easy for industrial production, and the use effect of the dental ulcer gel is perfect.
Description
Technical field
The present invention relates to drug gel technical field, especially a kind of oral ulcer gel and preparation method thereof.
Background technology
Oral ulcer is as a kind of common frequently-occurring disease, and its persistent period is long, due to special chemical environment in oral cavity and the effect of saliva mechanical erosion, systemic effect, make dosage form holdup times when local application such as traditional tablet, gargarism short, use inconvenient.
Summary of the invention
Technical problem to be solved by this invention is: a kind of oral ulcer gel and preparation method thereof is provided, and its good stability, film formation time is fast, and good antimicrobial effect, to overcome the deficiencies in the prior art.
The present invention is achieved in that oral ulcer gel, calculates by weight, comprises 0.3～4 part of polyvinyl alcohol, 0.2～2 part of chitosan, 15～40 parts, water, 0.3～2 part of glacial acetic acid, 0.5～4 part of adjuvant and 40-80 part dehydrated alcohol.。
Described adjuvant is one or more combination in any in medicine membrane resin, sodium alginate, ethyl cellulose, hydroxypropyl methylcellulose, Borneolum Syntheticum, xylitol, salicylic acid or tannin.
The preparation method of oral ulcer gel, gets each component, 1 by above-mentioned parts by weight) polyvinyl alcohol is dissolved in water after, then add chitosan, after stirring, add glacial acetic acid, then stirred, obtain water; 2) adjuvant is added in ethanol fully solution or dispersed after, obtain organic facies; 3), by water and organic facies mix homogeneously, after subpackage, obtain finished product.
The temperature that polyvinyl alcohol dissolves is 40-70 ℃, and dissolution time is 10-30min.
The incorporation time of water and organic facies is 10-30min.
In order to verify technique effect of the present invention, carried out following experiment:
The screening of 1 anti-biotic material and filmogen
The screening of 1.1 anti-biotic materials
Because chitosan and carboxymethyl chitosan have good antibacterial activity when concentration is 1% left and right, therefore first it is selected.Get two, clean 100mL beaker, add respectively distilled water 99mL, put into magnetic stir bar, under agitation, take respectively each 1.000g of chitosan and carboxymethyl chitosan and put into the 100mL beaker that is added with water, stir 30min, 1h, 2h, all can not dissolve, after stopping stirring, there is lamination: lower floor's chitosan and chitosan dry powder color are without significant change; And lower floor's carboxymethyl chitosan is compared with carboxymethyl chitosan dry powder, have a little Swelling and color to become to approach colourless, and form the required time of lamination and be obviously longer than chitosan.Even if the heating of long period can not occur that chitosan suspension and carboxymethyl chitosan suspension obviously change.
The screening of 1.2 solvents
Reconfigure each 4 parts of 1% chitosan and carboxymethyl chitosan suspensions, add respectively 0.5% boric acid, acetic acid, hydrochloric acid, sulphuric acid, result shows: carboxymethyl chitosan forms floccule after adding acid; Chitosan can present preferably transparent viscous solution shape under the effect of acetic acid, and chitosan under boric acid, hydrochloric acid, effect of sulfuric acid does not still dissolve and layering.
1% chitosan-acetic acid solution and carboxymethyl chitosan suspension are mixed to the rear semisolid that forms with a certain amount of polyvinyl alcohol, the coating uniformly of its equivalent is made to film, after oven dry, peeled, put into 37 ℃ of normal saline, in the film 1min that carboxymethyl chitosan becomes, disperse to disappear, the film that chitosan becomes disperses but does not disappear in 10min left and right.
By above-mentioned dissolubility, film, dissolve the time limit and test, determine that anti-biotic material is chitosan.
The selection of 1.3 filmogens
Get 3, clean 100mL beaker, put into magnetic stir bar, add respectively distilled water 50mL, minute another name medicine membrane resin 0486, polyvinyl alcohol 1788, polyvinyl alcohol 0588 each 2.000g put into corresponding beaker, stirring and dissolving.After dissolving, polyvinyl alcohol 0588 has heavier pungent plastics taste, and two other is without obvious abnormal smells from the patient.Get respectively 0.3mL solution, be uniformly coated on the rubber slab of 3cm * 3cm, after it is dry, taken off.When taking off film, pull in rubber gloves process, the film that medicine membrane resin 0486, polyvinyl alcohol are 0588 one-tenth significantly easily ruptures, illustrate that above-mentioned two kinds of filmogen toughness are poor, by contrast, polyvinyl alcohol 1788 has no irritating odor, and has good pliability, through test of many times, result is consistent.By above-mentioned experiment, filmogen is chosen for polyvinyl alcohol 1788.
The screening of 1.4 other adjuvants
In oral environment, have more mouth cavity liquid, in order to delay dissolution time, adjusting viscosity in conjunction with relevant data, chooses ethyl cellulose, hydroxypropyl cellulose as bonding regulator.
The chitosan of configuration 1% and 2% polyvinyl alcohol 1788 solution 100mL, rear 1g ethyl cellulose and the hydroxypropyl cellulose of adding respectively, after stirring, get on the rubber gloves that 0.3mL coats 3cm * 3cm, result shows: after adding ethyl cellulose group institute film forming dry, show white granular; Hydroxypropyl cellulose group institute film forming is colourless and smooth, and hydroxypropyl cellulose is chosen in experiment.
Get 3, clean 100mL beaker, put into magnetic stir bar, add 2g polyvinyl alcohol 1788, after dissolving, add 1g chitosan, after stirring, add 0.5mL acetic acid.Rear low-viscosity hydroxypropylcelluloand, medium viscosity hydroxypropyl cellulose, each 1g of Klucel EF of getting respectively, is scattered in 49mL95% ethanol.By after above-mentioned both mixing, get respectively 0.3mL and evenly coat on rubber gloves, after oven dry, put into 37 ℃ of normal saline.Last resolution time is as table 1.1:
Result shows: it is slow that medium viscosity and full-bodied hydroxypropyl cellulose dissolve resolution time, retention effect is better, and Klucel EF more can regulate the viscosity of gel, and the film becoming is without obvious granular sensation, chooses Klucel EF as experiment adjuvant.
The preliminary test of 1.5 ethanol contents
Because the dissolubility of each composition in ethanol is different, each composition alcohol dissolubility is tentatively examined or check.
1.5.1 chitosan dissolubility in ethanol
The 70% ethanol 50mL that configuration contains 1% acetic acid, adds respectively chitosan 0.050g, 0.100g, 0.150g, 0.200g, 0.250g, stirs.After 18h, chitosan does not dissolve, and stops stirring rear layering.Ethanol all in test can not be added to the water in advance, must first will after material dissolves, just can add.
Configure 1% chitosan suspension 10mL, stir after adding acetic acid, form thick liquid.Progressively add 95% ethanol, reach respectively 50%, 60%, 70%, 80% to concentration of alcohol, result shows: chitosan and ethanol have the good compatibility.
1.5.2 the dissolubility of polyvinyl alcohol
Get 5,50mL beaker, be numbered respectively No. 1-5, the polyvinyl alcohol 1788 that adds successively 0.050g, 0.100g, 0.150g, 0.200g, 0.250g, after add 3.7mL distilled water, stirring and dissolving, after add 95% ethanol 6.3mL, mix homogeneously, now concentration of alcohol is 60%, observes and whether has precipitation.Repeat aforesaid operations, add respectively commensurability chitosan, add successively distilled water 2.6 mL, 95% ethanol 7.4 mL, distilled water 1.6 mL, 95% ethanol 8.4 mL, be made into respectively concentration of alcohol and be 70%, 80% solution, and mix homogeneously, observes and whether have precipitation.Result is as table 1.2:
By experimental result, can be found out, in whole gel, when the mass percent of ethanol reaches 80%, occur white wadding hypostasis, so the biggest quality percent concentration of ethanol should be controlled at 70% left and right.And the parts by weight of dehydrated alcohol of the present invention just in time meet this requirement.
1.5.3 easily water suction and agglomerating of hydroxypropyl cellulose, cause dissolving difficulty, and can scatter preferably in the ethanol stirring, absorbing ethanol swelling, result shows, hydroxypropyl cellulose and 95% has the good compatibility, when hydroxy propyl cellulose cellulose content reaches 5%, its can form a mixture of pasty state grain and viscosity larger, through test of many times, when the content of control hydroxypropyl cellulose is 2% left and right, its viscosity is comparatively moderate.
2 chitosan gel rubber orthogonal tests
Choose PVA1788 consumption (A), CTS consumption (B), H-HPC consumption (C), 95% ethanol consumption (D) and carry out Orthogonal Experiment and Design as investigation factor.Using outward appearance, viscosity, film formation time, dissolution rate as evaluation index, the prescription of gel is optimized.Contrived experiment is as table 2.1:
By the result of showing, can be found out, four factors are D > B > A > C on the order of gel impact, and from quadrature result, preferably optimal result is A
2b
3c
4d
3, but because reaching 75%, ethanol degree makes to dissolve not exclusively, choose A
2b
3c
4d
2as optimal set, i.e. polyvinyl alcohol 1.5g, chitosan 0.7g, hydroxypropyl cellulose 1.75g, ethanol 73.7mL, Borneolum Syntheticum 0.125g, water 22.2mL.
3 Antibacterial Activities
According to preparation technology, prepare gel, negative gel (not adding chitosan), positive gel (chitosan is changed to penicillin sodium), get on the rubber slab that 0.1mL gel is applied to 3cm * 3cm, after oven dry, take off, make the circular film of 6mm, standby.
With card punch by gel film cut for diameter be that the circular piece of 6 mm is some.Sterilized culture dish, culture medium are put into after superclean bench is cooled to 60 ℃ and be down flat plate.The about 20mL of every ware, is finished down rear horizontal positioned culture dish, makes culture medium solidifying.With liquid-transfering gun, get 0.1 mL bacteria suspension and be added in culture dish, with spreading rod, be evenly coated with and open.Tweezers gripping gel diaphragm is placed on takes over the culture dish of planting, and every ware is put 2, is symmetrical and places.Each concentration do 3 groups parallel, put into incubator, be inverted to cultivate 25 ℃ of 48h(funguses for 37 ℃ and cultivate 24h), observed result is as following table.
4 vitro cytotoxicities are measured
4.1 L929 cytotoxic assay
(1) lixiviate medium: MEM cell culture fluid.
(2) laboratory sample group: 5mL gel is prepared film forming, puts into 100mL lixiviate medium by film, and in incubator, lixiviate 24h, prepares lixiviating solution.
(3) experimental technique: it is 1 * 10 that the eugonic L929 cell line of the 48-72h that goes down to posterity is diluted to concentration
4mL
-1cell suspending liquid, according to the amount in 100 μ L/ holes, be inoculated in 96 orifice plates, experiment arranges blank group, negative control group, positive controls and laboratory sample group, inoculate 6 holes for every group, be placed in after interior 24 h of cell culture incubator, discard culture fluid, blank group exchanges with cell culture fluid, the cell culture fluid exchange that is placed in 24 h in incubator for negative control group, cell culture fluid exchange containing 5% (V/V) DMSO for positive controls, laboratory sample group is with soaking the exchange of body fluid stock solution, again be placed in 37 ℃ of cultivation 72 h in cell culture incubator, be inverted observation of cell form and adherent growth situation under optical microscope, 20 μ L (5g/L) MTT solution-dyed 4h, discard in hole every hole after all liq and add 150 μ LDMSO, under room temperature, be placed in oscillator with (30 ± 5) r/min rotating speed decolouring 10min, at microplate reader 570nm and 630nm place, measure absorbance (OD) value immediately.
Determination methods:
(1) qualitatively judge: before MTT dyeing, by being inverted observation by light microscope, respectively organize cellular morphology, propagation situation, the toxic action level according to table 5.2 evaluation experimental sample sets to cell in vitro
Not.
(2) quantitatively judgement: the relative rate of increase (RGR) %=A/A
0* 100%, A: test sample group (lixiviate stock solution group, negative control group and positive controls) is in the difference of 570 nm and 630 nm place absorbances; A
0: blank group, in the difference of 570 nm and 630 nm place absorbances, goes out cytotoxicity rank according to table 5.3 correspondence.
Note: must meet negative control group simultaneously and be not more than 1 grade and positive controls and be at least the expection of 3 grades, can be according to table 5.5 or table 5.6 judgement toxicity rank.
4.2 MRC-5 cytotoxic assay
In like manner measure the cytotoxicity of MRC-5 cell line.
4.3 vitro cytotoxicity measurement results
(1) L929 cell line vitro cytotoxicity result
Observation of cell form after 72h, its microexamination result is as Fig. 1, and mtt assay measurement result is as Fig. 2.
(2) MRC-5 cell line vitro cytotoxicity result
Observation of cell form after 72h, microexamination result is as Fig. 3, and mtt assay measurement result is as Fig. 4.
From Fig. 1 and Fig. 3, can find out, gel is significantly less than positive group to the toxicity of L929 and MRC-5 cell line, and without significant difference, equal adherent growth is good, the obvious cytolysis phenomenon of nothing with feminine gender group.From the data of Fig. 2 and Fig. 4, according to cell quantitative classification standard, each gel all can be decided to be 2 grades, and positive controls is 3 grades, proves that gel has slight cytotoxicity to L929 and MRC-5 cell line.According to guideline, cytotoxicity is not more than 2 grades, is acceptable, meet the requirements, and equal high and other group gels of the relative inhibition of 5-10 ten thousand chitosans.
5 skin hypersensitivities and anaphylaxis experiment
5.1 skin hypersensitivity experiments
Get 30 of Cavia porcelluss (male and female half and half) and be divided at random 3 groups, 10 of negative (70% ethanol) matched groups, 10 of gel groups, 10 of positive (dinitro-chloro-benzene (DNCB)) matched groups.The front 24h of administration is animal spinal column right side skin depilatory (hair is cut short the 8% sodium sulfide depilation of rear use), depilation area 3cm * 3cm, the skin at experiment position requires intact, harmless injure abnormal.
(1) sensitization contact
Before administration, warm water cleaning depilation district, gets respectively 70% ethanol, gel, 1% 2,4-dinitro-chloro-benzene (DNCB, by 70% ethanol, be made into) each 0.2mL, directly coat each treated animal depilation district, then use the gauze of 3 layers of 2.5cm * 2.5cm to cover, after with nonirritant adhesive plaster, fixed.The 6h that all applies ointment or plaster, in 1,24,48h time point observes, and according to table 6.1, table 6.2 marking.
(2) excite contact
Excite first 24 hours by Cavia porcellus left of spine antimere skin depilatory, depilation area 3cm * 3cm.Within the 7th day and the 14th day, get respectively ethanol, gel, each 0.2mL of 1% 2,4-dinitro-chloro-benzene (DNCB is made into by 70% ethanol) after last sensitization are directly coated each depilation hair-fields, treated animal left side, the same sensitization contact of fixing means.3 groups of tested materials 6h that all applies ointment or plaster.Warm water washes away after the thing of applying ointment or plaster and at once observes, then in 24,48h observes skin allergy situation again.
Table 6.2 skin hypersensitivity evaluation criterion
When anaphylaxis incidence rate is 0, can be judged to and has no skin allergy
5.2 skin irritation test
(1) guinea pig skin depilation is prepared
24h before administration, guinea pig back spinal column diamond wool is cut short to rear use 8% sodium sulfide to be sloughed, every side depilation area is 3cm * 3cm left and right, after depilation, whether 24h inspection depilation place skin exists because of depilation and scratches place, and as skin injury, this Cavia porcellus is not suitable for use in the irritant experiment of intact skin, broken with aseptic needle point sterilization skin " ten " stroke that will lose hair or feathers, length is about 2.5cm, take oozing of blood as degree, and this Cavia porcellus is as the irritant experiment of damaged skin.
(2) single-dose skin irritation test
Be divided into intact skin group and damaged skin group, every group of 10 Cavia porcelluss, adopt the contrast of consubstantiality self left and right, depilation district, left side is coated with gel 0.5g, depilation district, right side is coated with ethanol 0.5mL in contrast, with gauze, cover and use immobilization with adhesive tape, give after tested material 24h, with Warm Wash, remove residual tested material, after eccysis tested material 1,24,48,72h perusal, record is coated with gel, ethanol place has or not the situations such as erythema and edema, result press table 5.3 skin irritation reaction standards of grading and is marked, calculate mean scores, and carry out stimulus intensity evaluation by table 5.4.
(3) skin irritation test of multiple dosing
Experimental technique and observational technique are still undertaken by single-dose experimental procedure, but same time administration every day every day 1 time, continuous 1 week, perusal after eccysis tested material 1,24,48,72h, the average response score value of gel and ethanol respectively organized in record, by table 6.3 standards of grading, scores and table 6.4 strength criterion judgement stimulus intensity.
5.3 experimental result
5.3.1 anaphylaxis experimental result
Gel group and ethanol group no significant difference, almost occur without red and swollen phenomenon; There is comparatively significantly erythema phenomenon in positive controls (DNCB group), without edema phenomenon, result is as table 6.5:
The irritated rate of ethanol group and gel group is 0, so the gel of preparation has no skin hypersensitivity reaction; And positive controls in sensitization contact, excite contact after 1,24h has strong sensitization, 48h has moderate sensitization.
5.3.2 irritant experiment result
(1) single-dose skin irritation test
The gel of intact skin group and ethanol matched group be indifference almost, does not have obvious red and swollen phenomenon to occur.All there is slight red and swollen phenomenon at edge of wound in the gel of damaged skin group and ethanol matched group, other parts are without red and swollen phenomenon.Experimental result is as table 6.6:
For the animal of intact skin group, the equal < 0.49 of average mark numerical value, shows that both are to normal skin nonirritant; To damaged skin treated animal, the mean scores of gel and ethanol is at the equal > 0.49 of 1h, but equal < 2.99, and also equal < 2.99 when 24h, show that both have slight zest to damaged skin, after 48h, zest almost disappears completely.
(2) multiple dosing skin irritation test
The gel of intact skin group and ethanol matched group be indifference almost, does not have obvious red and swollen phenomenon to occur; For damaged skin group, when administration for the third time continuously, there is the phenomenon that heals in wound, great majority healing during the 5th administration, and its result is as table 6.7:
For the animal of intact skin group, the equal < 0.49 of average mark numerical value, shows that both are to normal skin nonirritant; To damaged skin treated animal, the mean scores of gel and ethanol, at the equal < 0.49 of 1h, also shows that both are to normal skin nonirritant, and after 24h, zest almost disappears completely, and after 48h, wound is almost vanished from sight.
6 gels that make by technique are oral ulcer gel
In the present invention, oral ulcer gel mainly contains acceptable gel adjuvant on chitosan, polyvinyl alcohol, one or more pharmaceuticss.
The adjuvant of gel can adopt one or more the combination in any in medicine membrane resin, sodium alginate, ethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methylcellulose, xylitol, Borneolum Syntheticum, salicylic acid or tannin to use.
Oral ulcer gel of the present invention has the ethanol of higher concentration, and one or more that can be added in inhibiting bacteria and diminishing inflammation medicine stable in alcoholic solution are used in conjunction with.
The present invention can add the compound that has better film property, can keep preferably integrity and the toughness of film, as medicine membrane resin class.
The present invention can add one or more in salicylic acid, tannin etc. to be used in conjunction with in order to increase the stability of gel.
Compared with prior art, the present invention has carried out screening and optimizing to gel rubber material, preparation technology is optimized adjustment, the product stability obtaining is good, and film formation time is fast, good antimicrobial effect, and material source of the present invention is extensive, with low cost, preparation technology is easy to suitability for industrialized production, and result of use is desirable.
Accompanying drawing explanation
Accompanying drawing 1 is that different prescription gels are to L929 cytotoxicity microexamination figure; ;
Accompanying drawing 2 is the relative inhibition of gel to L929;
Accompanying drawing 3 is that different prescription gels are to MRC-5 cytotoxicity microexamination figure;
Accompanying drawing 4 is the relative inhibition of gel to MRC-5.
The specific embodiment
Embodiments of the invention 1: the preparation of oral ulcer gel, calculate by weight, get 0.4 part of polyvinyl alcohol 1788, in polyvinyl alcohol 1788, add 20 parts of water, the stirred in water bath of 40 ℃, within 30 minutes, dissolve, then add 0.5 part of chitosan in this solution, after stirring, add 0.5 part of glacial acetic acid, after being uniformly mixed, obtain water standby; Separately get 0.1 part of Borneolum Syntheticum and dissolved with 77 parts of dehydrated alcohol, then add 0.5 part of Klucel EF and 0.5 part of xylitol, limit edged stirs, and after stirring, obtains organic facies; Organic facies is added in water, stir and make gel mix homogeneously in 10 minutes, after subpackage, obtain finished product.
Embodiments of the invention 2: the preparation of oral ulcer gel, calculate by weight, get 3 parts of polyvinyl alcohol 1788, in polyvinyl alcohol 1788, add 41 parts of water, the stirred in water bath of 50 ℃, within 25 minutes, dissolve, then add 1.5 parts of chitosans in this solution, after stirring, add 1 part of glacial acetic acid, after being uniformly mixed, obtain water standby; Separately get 0.1 part of Borneolum Syntheticum and dissolved with 50 parts of dehydrated alcohol, then add 1 part of medicine membrane resin and 2 parts of hydroxypropyl celluloses, limit edged stirs, and after stirring, obtains organic facies; Organic facies is added in water, stir and make gel mix homogeneously in 15 minutes, after subpackage, obtain finished product.
Embodiments of the invention 3: the preparation of oral ulcer gel, calculate by weight, get 2 parts of polyvinyl alcohol 1788, in polyvinyl alcohol 1788, add 30 parts of water, the stirred in water bath of 60 ℃, within 20 minutes, dissolve, then add 1 part of chitosan in this solution, after stirring, add 0.5 part of glacial acetic acid, after being uniformly mixed, obtain water standby; Separately get 0.2 part of Borneolum Syntheticum and dissolved with 63 parts of dehydrated alcohol, then add 1 part of Klucel EF, 1 part of salicylic acid and 1 part of tannin, limit edged stirs, and after stirring, obtains organic facies; Organic facies is added in water, stir and make gel mix homogeneously in 20 minutes, after subpackage, obtain finished product.
Embodiments of the invention 4: the preparation of oral ulcer gel, calculate by weight, get 2.5 parts of polyvinyl alcohol 1788, in polyvinyl alcohol 1788, add 30 parts of water, the stirred in water bath of 70 ℃, within 15 minutes, dissolve, then add 1 part of chitosan in this solution, after stirring, add 0.5 part of glacial acetic acid, after being uniformly mixed, obtain water standby; Separately get 0.1 part of Borneolum Syntheticum and dissolved with 63 parts of dehydrated alcohol, then add 1.5 parts of Klucel EFs and 1.5 parts of sodium alginates, limit edged stirs, and after stirring, obtains organic facies; Organic facies is added in water, stir and make gel mix homogeneously in 25 minutes, after subpackage, obtain finished product.
Embodiments of the invention 5: the preparation of oral ulcer gel, calculate by weight, get 1.5 parts of polyvinyl alcohol 1788, in polyvinyl alcohol 1788, add 25 parts of water, the stirred in water bath of 65 ℃, within 15 minutes, dissolve, then add 0.7 part of chitosan in this solution, after stirring, add 0.5 part of glacial acetic acid, after being uniformly mixed, obtain water standby; Separately get 0.2 part of Borneolum Syntheticum and dissolved with 70 parts of dehydrated alcohol, then add 0.5 part of Klucel EF, 0.5 part of salicylic acid and 1 part of tannin, limit edged stirs, and after stirring, obtains organic facies; Organic facies is added in water, stir and make gel mix homogeneously in 30 minutes, after subpackage, obtain finished product.
Claims (5)
1. an oral ulcer gel, is characterized in that: calculate by weight, comprise 0.3～4 part of polyvinyl alcohol, 0.2～2 part of chitosan, 15～40 parts, water, 0.3～2 part of glacial acetic acid, 0.5～4 part of adjuvant and 40-80 part dehydrated alcohol.
2. oral ulcer gel according to claim 1, is characterized in that: described adjuvant is one or more combination in any in medicine membrane resin, sodium alginate, ethyl cellulose, hydroxypropyl methylcellulose, Borneolum Syntheticum, xylitol, salicylic acid or tannin.
3. a preparation method for oral ulcer gel as claimed in claim 1, is characterized in that: by above-mentioned parts by weight, get each component, 1) polyvinyl alcohol is dissolved in water after, add again chitosan, after stirring, add glacial acetic acid, then stirred, obtain water; 2) adjuvant is added in ethanol fully solution or dispersed after, obtain organic facies; 3), by water and organic facies mix homogeneously, after subpackage, obtain finished product.
4. the preparation method of oral ulcer gel according to claim 3, is characterized in that: the temperature that polyvinyl alcohol dissolves is 40-70 ℃, and dissolution time is 10-30min.
5. the preparation method of oral ulcer gel according to claim 3, is characterized in that: the incorporation time of water and organic facies is 10-30min.
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| CN105030659A (en) * | 2015-06-16 | 2015-11-11 | 贵州大学 | Gel for body surface wound and preparation method of gel |
| CN114652621A (en) * | 2022-03-31 | 2022-06-24 | 宁德师范学院 | Chitosan and silicon oxide composite hydrogel with high ethanol content |
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| CN101229146A (en) * | 2008-01-14 | 2008-07-30 | 浙江大学 | Chitosan and polyvinyl alcohol compound cataplasm matrix and preparing method thereof |
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| CN101229146A (en) * | 2008-01-14 | 2008-07-30 | 浙江大学 | Chitosan and polyvinyl alcohol compound cataplasm matrix and preparing method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105030659A (en) * | 2015-06-16 | 2015-11-11 | 贵州大学 | Gel for body surface wound and preparation method of gel |
| CN114652621A (en) * | 2022-03-31 | 2022-06-24 | 宁德师范学院 | Chitosan and silicon oxide composite hydrogel with high ethanol content |
| CN114652621B (en) * | 2022-03-31 | 2023-11-07 | 宁德师范学院 | High-ethanol-content chitosan silicon oxide composite hydrogel |
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