CN103965557A - Infusion bottle used corrosion-resistant rubber plug and preparation method thereof - Google Patents
Infusion bottle used corrosion-resistant rubber plug and preparation method thereof Download PDFInfo
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- CN103965557A CN103965557A CN201410146659.8A CN201410146659A CN103965557A CN 103965557 A CN103965557 A CN 103965557A CN 201410146659 A CN201410146659 A CN 201410146659A CN 103965557 A CN103965557 A CN 103965557A
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L23/00—Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers
- C08L23/26—Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers modified by chemical after-treatment
- C08L23/28—Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers modified by chemical after-treatment by reaction with halogens or compounds containing halogen
- C08L23/283—Halogenated homo- or copolymers of iso-olefins
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K3/00—Use of inorganic substances as compounding ingredients
- C08K3/18—Oxygen-containing compounds, e.g. metal carbonyls
- C08K3/20—Oxides; Hydroxides
- C08K3/22—Oxides; Hydroxides of metals
- C08K2003/2237—Oxides; Hydroxides of metals of titanium
- C08K2003/2241—Titanium dioxide
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K2201/00—Specific properties of additives
- C08K2201/014—Additives containing two or more different additives of the same subgroup in C08K
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2201/00—Properties
- C08L2201/08—Stabilised against heat, light or radiation or oxydation
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2205/00—Polymer mixtures characterised by other features
- C08L2205/03—Polymer mixtures characterised by other features containing three or more polymers in a blend
- C08L2205/035—Polymer mixtures characterised by other features containing three or more polymers in a blend containing four or more polymers in a blend
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2207/00—Properties characterising the ingredient of the composition
- C08L2207/06—Properties of polyethylene
- C08L2207/066—LDPE (radical process)
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- Chemical & Material Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
Abstract
The invention discloses an infusion bottle used corrosion-resistant rubber plug and a preparation method thereof. The infusion bottle used corrosion-resistant rubber plug is prepared from the following raw materials in parts by weight: 60-80 parts of brominated butyl rubber, 20-30 parts of ethylene-propylene-diene monomer rubber, 10-15 parts of neoprene, 1-2 parts of zinc oxide, 10-15 parts of titanium dioxide, 2-4 parts of vaseline, 0.4-0.6 part of precipitated white carbon black, 50-70 parts of calcined clay, 0.5-1 part of an accelerant DM, 0.5-1 part of an accelerant TMTM, 0.5-0.8 part of brominated octyl phenol aldehyde resin, 0.3 -0.5 part of pentaerythritol stearate, 2-4 parts of ricinus oil and 15-25 parts of modified packing. The rubber plug provided by the invention has excellent corrosion resistance and chemical stability, especially the acid-alkali resistance; the rubber plug cannot react with various medicines in long-term use, so that the valence of the medicines is conserved; moreover, as the rubber plug has favorable physical mechanical property, air tightness, age resistance, heat resistance and the like, the storage period of medicines can be prolonged, the qualified rate of the medicines is improved and the rubber plug is widely applied in openings sealing in various medical infusion bottles.
Description
Technical field
The present invention relates generally to a kind of plug and preparation method thereof, relates in particular to a kind of corrosion-resistant plug and preparation method thereof for infusion bottle.
Background technology
Plug is the important component part of sealing material in infusion bottle, be the main sealed piece of infusion bottle and lead a mouthful part, because he directly contacts with medicine, therefore may be by mode and medicine generation cross reactions such as absorption, absorption, infiltration and extractings, thereby impact and pollution medicine, so pharmacopoeia of each country and related standards have all been made extremely strict regulation to the use of plug and performance.Isoprene-isobutylene rubber replaces natural rubber with its higher physical strength, good resistance to air loss, low-permeability and the performance such as ageing-resistant and is widely used and makes to produce medical rubber plug, it is poor that but on market also there is erosion resistance in existing butyl rubber stoppers, acid and the stronger special medicine of solvent of alkalescence particularly, may destroy plug, affect sealing effectiveness.
Summary of the invention
The object of the invention is just to provide a kind of corrosion-resistant plug and preparation method thereof for infusion bottle, improves the acid-proof alkaline of butyl rubber stoppers.
For achieving the above object, the present invention adopts following technical scheme:
The corrosion-resistant plug of infusion bottle, it is to be made by the raw material of following weight parts:
Brominated butyl rubber 60-80, terpolymer EP rubber 20-30, chloroprene rubber 10-15, zinc oxide 1-2, titanium dioxide 10-15, Vaseline 2-4, precipitated silica 0.4-0.6, calcinated argil 50-70, altax 0.5-1, TM monex TM0.5-1, bromination octyl phenol urea formaldehyde 0.5-0.8, pentaerythritol stearate 0.3-0.5, Viscotrol C 2-4, modified filler 15-25;
The preparation method of described modified filler is as follows: a, get the raw material of following weight part: fibrolite 12-18, peridotites 10-15, phosphatic rock 5-10, Low Density Polyethylene 15-20, voltalef 8-14, ethene-vinyl acetate-carbonyl terpolymer 6-12, magnesium oxide 2-3, stearic acid 1-2, bamboo charcoal powder 2.5-4.5, tourmaline powder 2-3, sec.-propyl three (dioctylphyrophosphoric acid acyloxy) titanic acid ester 1-2, epoxy soybean oil 4-8, low molecular weight polycaprolactone butylene 3-6; B, to get fibrolite, peridotites, apatites mixed even, 660-720 ℃ of calcining 2-3h, naturally cool to room temperature, pulverize, cross 100-150 mesh sieve, then add sec.-propyl three (dioctylphyrophosphoric acid acyloxy) titanic acid ester, epoxy soybean oil, low molecular weight polycaprolactone butylene, magnesium oxide, stearic acid, bamboo charcoal powder, tourmaline powder, 1000-1500rpm speed lapping 10-15min, stand-by; B, get Low Density Polyethylene, voltalef, ethene-vinyl acetate-carbonyl terpolymer and drop into melt blending in twin screw extruder, after it melts completely, add above-mentioned ground compound, extruding pelletization, naturally cool to room temperature, be modified filler.
The preparation method of corrosion-resistant plug for infusion bottle, comprises the following steps:
(1) brominated butyl rubber, terpolymer EP rubber, chloroprene rubber are dropped in milling machine to pressurization 0.5-0.7MPa, temperature 40-50 ℃, mixing 1-2min, drop into again other raw material except zinc oxide, bromination octyl phenol urea formaldehyde and modified filler, pressurization 0.5-0.7MPa, temperature 70-80 ℃, mixing 3-5min, then drop into zinc oxide, bromination octyl phenol urea formaldehyde and modified filler, pressurization 0.5-0.7MPa, temperature 90-100 ℃, mixing 2-4min, discharge;
(2) mill roll spacing is adjusted to 3-5mm, and the sizing material that milling machine is got rid of drops into thin-pass in mill, until roller temperature, reaches after 50-60 ℃, continues thin-pass 20-30min, waits after the sticky rear roller of film, becomes atresia woven design shape to get final product blanking, places 24-36h;
(3) the above-mentioned film making is injected to sulfidization molding after cooling, cut-parts, curing temperature is 180-200 ℃, and sulfide stress is 20-25MPa, and screw tube temperature is 60-70 ℃, and injection tube temperature is 80-90 ℃, and cold runner temperature is 80-90 ℃;
(4) film of moulding gets product through die-cut, screening, cleaning, silication, dry, test package.
Advantage of the present invention is:
Plug of the present invention has excellent erosion resistance and chemical stability, acid-proof alkaline particularly, life-time service and various medicine do not react, thereby keep tiring of medicine, and there is the performances such as good physical and mechanical properties, resistance to air loss, ageing resistance, thermotolerance, storage period that can prolong drug, improve the qualification rate of medicine.Be widely used in the sealing of various medical transfusion bottlenecks.
Embodiment
Embodiment 1
The corrosion-resistant plug of infusion bottle, it is to be made by the raw material of following weight (kg):
Brominated butyl rubber 70, terpolymer EP rubber 25, chloroprene rubber 12, zinc oxide 1.5, titanium dioxide 10, Vaseline 3, precipitated silica 0.5, calcinated argil 60, altax 0.8, TM monex TM0.6, bromination octyl phenol urea formaldehyde 0.7, pentaerythritol stearate 0.4, Viscotrol C 3, modified filler 20;
The preparation method of described modified filler is as follows: a, get the raw material of following weight (kg): fibrolite 16, peridotites 12, phosphatic rock 8, Low Density Polyethylene 10, voltalef 12, ethene-vinyl acetate-carbonyl terpolymer 8, magnesium oxide 2, stearic acid 1.5, bamboo charcoal powder 3.5, tourmaline powder 2, sec.-propyl three (dioctylphyrophosphoric acid acyloxy) titanic acid ester 1, epoxy soybean oil 6, low molecular weight polycaprolactone butylene 4; B, to get fibrolite, peridotites, apatites mixed even, 720 ℃ of calcining 2h, naturally cool to room temperature, pulverize, cross 150 mesh sieves, then add sec.-propyl three (dioctylphyrophosphoric acid acyloxy) titanic acid ester, epoxy soybean oil, low molecular weight polycaprolactone butylene, magnesium oxide, stearic acid, bamboo charcoal powder, tourmaline powder, 1500rpm speed lapping 10min, stand-by; B, get Low Density Polyethylene, voltalef, ethene-vinyl acetate-carbonyl terpolymer and drop into melt blending in twin screw extruder, after it melts completely, add above-mentioned ground compound, extruding pelletization, naturally cool to room temperature, be modified filler.
The preparation method of corrosion-resistant plug for infusion bottle, comprises the following steps:
(1) brominated butyl rubber, terpolymer EP rubber, chloroprene rubber are dropped in milling machine to pressurization 0.6MPa, temperature 45 C, mixing 1min, drop into again other raw material except zinc oxide, bromination octyl phenol urea formaldehyde and modified filler, pressurization 0.6MPa, 75 ℃ of temperature, mixing 4min, then drop into zinc oxide, bromination octyl phenol urea formaldehyde and modified filler, pressurization 0.6MPa, 95 ℃ of temperature, mixing 3min, discharge;
(2) mill roll spacing is adjusted to 4mm, and the sizing material that milling machine is got rid of drops into thin-pass in mill, until roller temperature, reaches after 55 ℃, continues thin-pass 25min, waits after the sticky rear roller of film, becomes atresia woven design shape to get final product blanking, places 36h;
(3) the above-mentioned film making is injected to sulfidization molding after cooling, cut-parts, curing temperature is 190 ℃, and sulfide stress is 20-25MPa, and screw tube temperature is 60 ℃, and injection tube temperature is 85 ℃, and cold runner temperature is 85 ℃;
(4) film of moulding gets product through die-cut, screening, cleaning, silication, dry, test package.
The performance test results is as following table:
Claims (2)
1. the corrosion-resistant plug of infusion bottle, is characterized in that, it is to be made by the raw material of following weight parts:
Brominated butyl rubber 60-80, terpolymer EP rubber 20-30, chloroprene rubber 10-15, zinc oxide 1-2, titanium dioxide 10-15, Vaseline 2-4, precipitated silica 0.4-0.6, calcinated argil 50-70, altax 0.5-1, TM monex TM 0.5-1, bromination octyl phenol urea formaldehyde 0.5-0.8, pentaerythritol stearate 0.3-0.5, Viscotrol C 2-4, modified filler 15-25;
The preparation method of described modified filler is as follows: a, get the raw material of following weight part: fibrolite 12-18, peridotites 10-15, phosphatic rock 5-10, Low Density Polyethylene 15-20, voltalef 8-14, ethene-vinyl acetate-carbonyl terpolymer 6-12, magnesium oxide 2-3, stearic acid 1-2, bamboo charcoal powder 2.5-4.5, tourmaline powder 2-3, sec.-propyl three (dioctylphyrophosphoric acid acyloxy) titanic acid ester 1-2, epoxy soybean oil 4-8, low molecular weight polycaprolactone butylene 3-6; B, to get fibrolite, peridotites, apatites mixed even, 660-720 ℃ of calcining 2-3h, naturally cool to room temperature, pulverize, cross 100-150 mesh sieve, then add sec.-propyl three (dioctylphyrophosphoric acid acyloxy) titanic acid ester, epoxy soybean oil, low molecular weight polycaprolactone butylene, magnesium oxide, stearic acid, bamboo charcoal powder, tourmaline powder, 1000-1500rpm speed lapping 10-15min, stand-by; B, get Low Density Polyethylene, voltalef, ethene-vinyl acetate-carbonyl terpolymer and drop into melt blending in twin screw extruder, after it melts completely, add above-mentioned ground compound, extruding pelletization, naturally cool to room temperature, be modified filler.
2. the preparation method of corrosion-resistant plug for infusion bottle as claimed in claim 1, is characterized in that comprising the following steps:
(1) brominated butyl rubber, terpolymer EP rubber, chloroprene rubber are dropped in milling machine to pressurization 0.5-0.7MPa, temperature 40-50 ℃, mixing 1-2min, drop into again other raw material except zinc oxide, bromination octyl phenol urea formaldehyde and modified filler, pressurization 0.5-0.7MPa, temperature 70-80 ℃, mixing 3-5min, then drop into zinc oxide, bromination octyl phenol urea formaldehyde and modified filler, pressurization 0.5-0.7MPa, temperature 90-100 ℃, mixing 2-4min, discharge;
(2) mill roll spacing is adjusted to 3-5mm, and the sizing material that milling machine is got rid of drops into thin-pass in mill, until roller temperature, reaches after 50-60 ℃, continues thin-pass 20-30min, waits after the sticky rear roller of film, becomes atresia woven design shape to get final product blanking, places 24-36h;
(3) the above-mentioned film making is injected to sulfidization molding after cooling, cut-parts, curing temperature is 180-200 ℃, and sulfide stress is 20-25MPa, and screw tube temperature is 60-70 ℃, and injection tube temperature is 80-90 ℃, and cold runner temperature is 80-90 ℃;
(4) film of moulding gets product through die-cut, screening, cleaning, silication, dry, test package.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410146659.8A CN103965557A (en) | 2014-04-11 | 2014-04-11 | Infusion bottle used corrosion-resistant rubber plug and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410146659.8A CN103965557A (en) | 2014-04-11 | 2014-04-11 | Infusion bottle used corrosion-resistant rubber plug and preparation method thereof |
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| CN103965557A true CN103965557A (en) | 2014-08-06 |
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| CN201410146659.8A Pending CN103965557A (en) | 2014-04-11 | 2014-04-11 | Infusion bottle used corrosion-resistant rubber plug and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105037980A (en) * | 2015-07-09 | 2015-11-11 | 安徽省华洋橡胶有限公司 | Flame-retardant butyl rubber inner tube material |
| CN105524357A (en) * | 2014-09-29 | 2016-04-27 | 中国石油化工股份有限公司 | Thermoplastic vulcanizate and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101326239A (en) * | 2005-12-05 | 2008-12-17 | 埃克森美孚化学专利公司 | Processing agent for elastic body composition |
| CN101376730A (en) * | 2007-08-31 | 2009-03-04 | 谷其昌 | Thermoplastic elastomer material, preparation thereof and method for manufacturing medicinal bottle stopper by using the same |
-
2014
- 2014-04-11 CN CN201410146659.8A patent/CN103965557A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101326239A (en) * | 2005-12-05 | 2008-12-17 | 埃克森美孚化学专利公司 | Processing agent for elastic body composition |
| CN101376730A (en) * | 2007-08-31 | 2009-03-04 | 谷其昌 | Thermoplastic elastomer material, preparation thereof and method for manufacturing medicinal bottle stopper by using the same |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105524357A (en) * | 2014-09-29 | 2016-04-27 | 中国石油化工股份有限公司 | Thermoplastic vulcanizate and preparation method thereof |
| CN105524357B (en) * | 2014-09-29 | 2017-12-22 | 中国石油化工股份有限公司 | A kind of TPV and preparation method thereof |
| CN105037980A (en) * | 2015-07-09 | 2015-11-11 | 安徽省华洋橡胶有限公司 | Flame-retardant butyl rubber inner tube material |
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Address after: 238371 Yao Gou Industrial Zone, Wuhu, Anhui, Wuwei County Applicant after: ANHUI HUANENG MEDICAL RUBBER PRODUCTS CO., LTD. Address before: 238371 Yao Gou Industrial Zone, Wuhu, Anhui, Wuwei County Applicant before: Anhui Huaneng Medical Rubber Products Co., Ltd. |
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Application publication date: 20140806 |