CN103964006B - Drug liquid filling method - Google Patents
Drug liquid filling method Download PDFInfo
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- CN103964006B CN103964006B CN201410189912.8A CN201410189912A CN103964006B CN 103964006 B CN103964006 B CN 103964006B CN 201410189912 A CN201410189912 A CN 201410189912A CN 103964006 B CN103964006 B CN 103964006B
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- transfusion bag
- bag
- transfusion
- fill
- drug liquid
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Abstract
The invention discloses a drug liquid filling method which includes the steps of injecting 60 DEG C-70 DEG C drug liquid in a transfusion bag, enabling air in the transfusion bag to expand through heat to be overflowed out through the temperature of the drug liquid, and sealing an opening of the transfusion bag after the air in the transfusion bag is overflowed out. The drug liquid filling method is suitable for bagged or bottled drug liquid production, the principle of heat expansion and chilling shrinkage is adopted, the transfusion bag with the drug liquid is heated at a high temperature, the air in the transfusion bag expands, and redundant air in the transfusion bag is exhausted out of the transfusion bag. Compared with an existing method that an idler wheel is adopted for pressurization and exhausting, the drug liquid filling method has the advantages that the control difficulty is reduced, a user does not need to be in contact with the transfusion bag, the transfusion bag is prevented from being damaged, the high coincidence is kept when batch exhausting is carried out, the appearance quality of the transfusion bag after sterilization is good, concave bottoms are basically avoided, and the bottle type is attractive.
Description
Technical field
The present invention relates to medicinal liquid production field, the method especially medicinal liquid being carried out fill.
Background technology
In medical liquid medicine production process, such as currently producing 100ml, 250ml specification vertical polypropylene transfusion bag
During, many for transfusion bag residual gas after avoiding sterilizing, cause pouch-shaped expansion, astasia, the ropy feelings of product appearance
Condition.The blind enema of gas in commonly used roller bearing extruding transfusion bag when fill, i.e. after injecting medicinal liquid, utilizes roller bearing to infuse
Gas extrusion unnecessary in Dai, seals after extrusion.This mechanical type method for exhausting requires that operation precision is high, it is big to control difficulty；
Transfusion bag is to be extruded by roller bearing in running, and transfusion bag discontinuity, during aerofluxus, concordance is poor in batches；Roller bearing with
There is, during directly contacting, the hidden danger scratching transfusion bag in transfusion bag；And extruding after the sterilized rear bottle-type of transfusion bag poor,
Sunken bottom is many, has a strong impact on the presentation quality of product, it is impossible to meet market demand.
Summary of the invention
For problems of the prior art, it is an object of the invention to provide a kind of medicine liquid packaging process, should
Packaging process is applicable to the packed or production of bottled medicinal liquor, utilizes the principle that gas expands with heat and contract with cold, by carrying out dilute vehicle
It is heated to 60 ° of C-70 ° of C, injects transfusion bag, be allowed to the gas expanding in transfusion bag, air unnecessary in transfusion bag is discharged defeated
Liquid bag, advantage is compared with the existing method utilizing roller pressure exhaust, controls difficulty and reduces, it is not necessary to carries out transfusion bag
Contact, it is to avoid damage transfusion bag, can keep higher concordance in batches during aerofluxus, after sterilizing, transfusion bag presentation quality is good, base
Originally not having sunken bottom, bottle-type is attractive in appearance.
To achieve these goals, one liquid medicine filling method of the present invention, this packaging process includes: inject in transfusion bag
The medicinal liquid of 60 ° of C-70 ° of C, in making transfusion bag by medicinal liquid own temperature, air flatulence of heat type is overflowed, after gas overflowing in transfusion bag,
Transfusion bag is carried out pressurizing window.
The present invention has broken the processing method of traditional extruding aerofluxus, and it is many that the principle utilizing gas to expand with heat and contract with cold realizes discharge
The purpose of residual air body, it is only necessary to control fluid temperature, it is achieved simple, operation easier is low, when producing in batches, effect is more
Substantially, aerofluxus concordance is high, and production efficiency significantly improves, and finished product pouch-type is attractive in appearance.
Detailed description of the invention
Accomplish the end in view and effect, below in conjunction with tool to describe the liquid medicine filling method how utilizing the present invention in detail
Body embodiment elaborates.
The present embodiment herb liquid fill is to complete on the production line of the automatization commonly used in the industry.
1, the infusion bottle (bag) after cleaning is after fill bottle inlet refutes the sensing of dish photoswitch, fill finger clamp position bottle (bag),
Entering fill station, photoswitch generation signal to PLC, PLC sends instruction, and valve island controls switch open, controls pneumatic diaphragm
Valve automatically opens up, and fill head tracking infusion bottle (bag), by the medicinal liquid of 60 ° of C-70 ° of C, is injected in infusion bottle (bag).
2, after fill, fill finger clamps infusion bottle (bag) neck, refutes dish through handing-over entrance bottle outlet and is delivered to welding cap work
Position.
3, the infusion bottle (bag) after fill is after fill bottle outlet refutes dish entrance welding cap station, welding cap machine finger clamp position bottle (bag)
Neck, when the sensing of mechanism of push bottles ahead photoswitch has bottle (bag), polypropylene combination cover enters a point lid and refutes dish, and a point lid is refuted dish and extracted poly-third
Alkene composite cover, cap taking mechanism descending crawl polypropylene combination cover.
4, welder is advanced into and takes between lid finger and welding cap finger, by polypropylene combination cover solder side and bottle (bag) mouth
The most untouchable pasty state that is heated into, being about to polypropylene combination cover under cap taking mechanism welds together with bottle (bag) mouth pressing, complete
Become aerofluxus and sealing.
5, the semi-finished product after welding cap through bottle outlet refute dish send into bottle outlet orbit transports go out clean area.
Above-mentioned example is only intended to the present invention is described, embodiments of the present invention are not limited to these examples, this area skill
What art personnel were made meets the various detailed description of the invention of inventive concept all within protection scope of the present invention.
Claims (1)
1. a liquid medicine filling method, this packaging process includes:
Step 1, the transfusion bag after cleaning is after the photoswitch sensing that fill bottle inlet refutes dish, and transfusion is stated in fill finger clamp residence
Bag, enters fill station, and described photoswitch generation signal is to PLC, and this PLC sends instruction, and valve island controls switch open, controls
Pneumatic diaphragm valve automatically opens up, and fill head tracking transfusion bag, by the medicinal liquid of 60 ° of C-70 ° of C, is injected in transfusion bottle bag, passed through medicinal liquid
In own temperature makes transfusion bag, air flatulence of heat type is overflowed；
Step 2, after fill, described fill finger clamps transfusion bag neck, refutes dish through handing-over entrance bottle outlet and is delivered to welding cap work
Position；
Step 3, after entering welding cap station, welding cap tractor driver refers to clamp transfusion bag neck, when the sensing of mechanism of push bottles ahead photoswitch has transfusion
During bag, polypropylene combination cover enters a point lid and refutes dish, and this point of lid is refuted dish and extracted described polypropylene combination cover, the descending crawl of cap taking mechanism
Polypropylene combination cover；
Step 4, welder is advanced into and takes between lid finger and described welding cap finger, by polypropylene combination cover solder side and bag mouth
The most untouchable pasty state that is heated into, being about to polypropylene combination cover under cap taking mechanism welds together with bag mouth pressing, the row of completing
Gas and sealing；
Step 5, the semi-finished product after welding cap are refuted dish feeding bottle outlet orbit transports through bottle outlet and are gone out clean area.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410189912.8A CN103964006B (en) | 2014-05-07 | 2014-05-07 | Drug liquid filling method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410189912.8A CN103964006B (en) | 2014-05-07 | 2014-05-07 | Drug liquid filling method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103964006A CN103964006A (en) | 2014-08-06 |
| CN103964006B true CN103964006B (en) | 2017-01-11 |
Family
ID=51234109
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410189912.8A Active CN103964006B (en) | 2014-05-07 | 2014-05-07 | Drug liquid filling method |
Country Status (1)
| Country | Link |
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| CN (1) | CN103964006B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107651644A (en) * | 2017-08-31 | 2018-02-02 | 芜湖杨燕制药有限公司 | A kind of insect-expelling saligna injection liquid handles filling process |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4428897B2 (en) * | 2001-10-31 | 2010-03-10 | ハウス食品株式会社 | Method and apparatus for manufacturing food-filled packaging bag |
| CN100415611C (en) * | 2005-08-26 | 2008-09-03 | 湖南千山制药机械股份有限公司 | Single-mouth pipe liquid-solid type two-chamber non-PVC film soft-bag large-infusion automatic production line |
| JP4905683B2 (en) * | 2007-01-22 | 2012-03-28 | 東洋製罐株式会社 | Liquid content filling and sealing method for pouch with spout and apparatus therefor |
| DE102009014857B4 (en) * | 2009-03-30 | 2014-06-26 | Khs Gmbh | Method for filling bottles or similar containers and filling machine |
| CN202295429U (en) * | 2011-07-19 | 2012-07-04 | 上海联业农业科技有限公司 | Degassing hot sealing system aiming at fine powder and light material package |
| CN103431325B (en) * | 2013-08-23 | 2016-03-30 | 艾得客实业（上海）有限公司 | A kind of deep process of watermelon |
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2014
- 2014-05-07 CN CN201410189912.8A patent/CN103964006B/en active Active
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| Publication number | Publication date |
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| CN103964006A (en) | 2014-08-06 |
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