CN107651644A - A kind of insect-expelling saligna injection liquid handles filling process - Google Patents
A kind of insect-expelling saligna injection liquid handles filling process Download PDFInfo
- Publication number
- CN107651644A CN107651644A CN201710767605.7A CN201710767605A CN107651644A CN 107651644 A CN107651644 A CN 107651644A CN 201710767605 A CN201710767605 A CN 201710767605A CN 107651644 A CN107651644 A CN 107651644A
- Authority
- CN
- China
- Prior art keywords
- parenteral solution
- infusion bottle
- filling
- insect
- injection liquid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B67—OPENING, CLOSING OR CLEANING BOTTLES, JARS OR SIMILAR CONTAINERS; LIQUID HANDLING
- B67C—CLEANING, FILLING WITH LIQUIDS OR SEMILIQUIDS, OR EMPTYING, OF BOTTLES, JARS, CANS, CASKS, BARRELS, OR SIMILAR CONTAINERS, NOT OTHERWISE PROVIDED FOR; FUNNELS
- B67C7/00—Concurrent cleaning, filling, and closing of bottles; Processes or devices for at least two of these operations
- B67C7/0073—Sterilising, aseptic filling and closing
- B67C7/008—Sterilising, aseptic filling and closing comprising a cleaning step between two closing steps
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B3/00—Packaging plastic material, semiliquids, liquids or mixed solids and liquids, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, or jars
- B65B3/003—Filling medical containers such as ampoules, vials, syringes or the like
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B63/00—Auxiliary devices, not otherwise provided for, for operating on articles or materials to be packaged
- B65B63/08—Auxiliary devices, not otherwise provided for, for operating on articles or materials to be packaged for heating or cooling articles or materials to facilitate packaging
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B67—OPENING, CLOSING OR CLEANING BOTTLES, JARS OR SIMILAR CONTAINERS; LIQUID HANDLING
- B67C—CLEANING, FILLING WITH LIQUIDS OR SEMILIQUIDS, OR EMPTYING, OF BOTTLES, JARS, CANS, CASKS, BARRELS, OR SIMILAR CONTAINERS, NOT OTHERWISE PROVIDED FOR; FUNNELS
- B67C3/00—Bottling liquids or semiliquids; Filling jars or cans with liquids or semiliquids using bottling or like apparatus; Filling casks or barrels with liquids or semiliquids
- B67C3/02—Bottling liquids or semiliquids; Filling jars or cans with liquids or semiliquids using bottling or like apparatus
- B67C3/22—Details
Landscapes
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Basic Packing Technique (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
Abstract
The present invention provides a kind of insect-expelling saligna injection liquid processing filling process, and the processing filling process step is as follows：Step 1：Parenteral solution is extracted out from configuration bucket, and heating treatment is continued to parenteral solution；Step 2：Parenteral solution after will heat up is stood at room temperature, is ensured that parenteral solution is tranquil and is placed；Step 3：Parenteral solution is passed through in bottle placer prepare it is filling；Step 4：Infusion bottle is cleaned, and is put into dryer and is dried；Step 5：Infusion bottle is put into bottle placer, parenteral solution is poured into infusion bottle；Step 6：Infusion bottle mouth is sealed, and infusion bottle is placed on leak-testing apparatus and carries out sealing propertytest；Step 7：The infusion bottle qualified to sealing be put into freezer cool down it is standby.Processing is exhausted to parenteral solution before filling, and is sealed at once after filling, improves filling efficiency, lifts the use quality of parenteral solution, solves the problems, such as filling ineffective when insect-expelling saligna injection liquid is filling and easy pressure release.
Description
Technical field
The present invention relates to traditional Chinese medicine preparation field, more particularly to a kind of insect-expelling saligna injection liquid to handle filling work
Skill.
Background technology
At present when being prepared to insect-expelling saligna injection liquid, it is necessary to using bottle placer that parenteral solution is filling to infusion bottle
In, at present to parenteral solution carry out it is filling when, typically directly carried out by bottle placer it is filling, but not to parenteral solution carry out
Pump-down process, easily there is filling error, cause parenteral solution to be contaminated, and, it is necessary to be carried out to infusion bottle after the completion of filling
Sealing, ensure infusion bottle in pressure, but at present to infusion bottle carry out it is filling after, seal operation can not be completed in time, easily
There is infusion bottle pressure release, cause pressure in the bottle deficiency of infusing, influence the use of parenteral solution.Therefore, solves vernonia anthelmintica injection
Just it is particularly important the problem of filling ineffective and easy pressure release when liquid is filling.
The content of the invention
In view of the above-mentioned problems of the prior art, it is an object of the invention to provide a kind of processing of insect-expelling saligna injection liquid
Filling process, by heating-standing-preparation it is filling-processing step of body cleaning-filling-sealing-refrigeration completes parenteral solution
Filling process is handled, parenteral solution is exhausted before filling processing, and is sealed at once after filling, solves expelling parasite
When saligna injection liquid is filling the problem of filling ineffective and easy pressure release.
The present invention provides a kind of insect-expelling saligna injection liquid processing filling process, and the processing filling process step is as follows：
Step 1：Parenteral solution is extracted out from configuration bucket, and heating treatment is continued to parenteral solution；
Step 2：Parenteral solution after will heat up is stood at room temperature, is ensured that parenteral solution is tranquil and is placed；
Step 3：Parenteral solution is passed through in bottle placer prepare it is filling；
Step 4：Infusion bottle is cleaned, and is put into dryer and is dried；
Step 5：Infusion bottle is put into bottle placer, parenteral solution is poured into infusion bottle；
Step 6：Infusion bottle mouth is sealed, and infusion bottle is placed on progress sealing inspection on leak-testing apparatus
Survey；
Step 7：The infusion bottle qualified to sealing be put into freezer cool down it is standby.
Further improvement is that：When being heated up in the step 1 to parenteral solution, ensure parenteral solution temperature with 5 DEG C/min
Programming rate heated up, the heating maximum temperature of parenteral solution is no more than 70 DEG C.
Further improvement is that：Time of repose when being stood in the step 2 to parenteral solution is 2 hours.
Further improvement is that：Transfusion bottle surface is wiped after sealing detection is carried out to infusion bottle in the step 6
Cleaning.
The beneficial effects of the invention are as follows：By heating-standing-preparation it is filling-work of body cleaning-filling-sealing-refrigeration
Skill step completes the processing filling process of parenteral solution, parenteral solution is exhausted before filling processing, and after filling at once
Sealed, improve filling efficiency, lift the use quality of parenteral solution.
Embodiment
In order to deepen the understanding of the present invention, below in conjunction with embodiment, the invention will be further described, the embodiment
It is only used for explaining the present invention, is not intended to limit the scope of the present invention..
A kind of insect-expelling saligna injection liquid processing filling process is present embodiments provided, the processing filling process step is such as
Under：
Step 1：Parenteral solution is extracted out from configuration bucket, and heating treatment is continued to parenteral solution；
Step 2：Parenteral solution after will heat up is stood at room temperature, is ensured that parenteral solution is tranquil and is placed；
Step 3：Parenteral solution is passed through in bottle placer prepare it is filling；
Step 4：Infusion bottle is cleaned, and is put into dryer and is dried；
Step 5：Infusion bottle is put into bottle placer, parenteral solution is poured into infusion bottle；
Step 6：Infusion bottle mouth is sealed, and infusion bottle is placed on progress sealing inspection on leak-testing apparatus
Survey；
Step 7：The infusion bottle qualified to sealing be put into freezer cool down it is standby.
When being heated up in the step 1 to parenteral solution, ensure that parenteral solution temperature is carried out with 5 DEG C/min programming rate
Heating, the heating maximum temperature of parenteral solution is 65 DEG C.Time of repose when being stood in the step 2 to parenteral solution is small for 2
When.Wiping cleaning is carried out to transfusion bottle surface after carrying out sealing detection in the step 6 to infusion bottle.By heating-standing-
The processing step for preparing filling-body cleaning-filling-sealing-refrigeration completes the processing filling process of parenteral solution, before filling
Processing is exhausted to parenteral solution, and is sealed at once after filling, improves filling efficiency, lift parenteral solution uses product
Matter.
Claims (4)
1. a kind of insect-expelling saligna injection liquid handles filling process, it is characterised in that：The processing filling process step is as follows：
Step 1：Parenteral solution is extracted out from configuration bucket, and heating treatment is continued to parenteral solution；
Step 2：Parenteral solution after will heat up is stood at room temperature, is ensured that parenteral solution is tranquil and is placed；
Step 3：Parenteral solution is passed through in bottle placer prepare it is filling；
Step 4：Infusion bottle is cleaned, and is put into dryer and is dried；
Step 5：Infusion bottle is put into bottle placer, parenteral solution is poured into infusion bottle；
Step 6：Infusion bottle mouth is sealed, and infusion bottle is placed on progress sealing inspection on leak-testing apparatus
Survey；
Step 7：The infusion bottle qualified to sealing be put into freezer cool down it is standby.
A kind of 2. insect-expelling saligna injection liquid processing filling process as claimed in claim 1, it is characterised in that：The step 1
In when being heated up to parenteral solution, ensure that parenteral solution temperature is heated up with 5 DEG C/min programming rate, the heating of parenteral solution is most
High-temperature is no more than 70 DEG C.
A kind of 3. insect-expelling saligna injection liquid processing filling process as claimed in claim 1, it is characterised in that：The step 2
In time of repose when being stood to parenteral solution be 2 hours.
A kind of 4. insect-expelling saligna injection liquid processing filling process as claimed in claim 1, it is characterised in that：The step 6
In to infusion bottle carry out sealing detection after to transfusion bottle surface carry out wiping cleaning.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710767605.7A CN107651644A (en) | 2017-08-31 | 2017-08-31 | A kind of insect-expelling saligna injection liquid handles filling process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710767605.7A CN107651644A (en) | 2017-08-31 | 2017-08-31 | A kind of insect-expelling saligna injection liquid handles filling process |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107651644A true CN107651644A (en) | 2018-02-02 |
Family
ID=61129016
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710767605.7A Pending CN107651644A (en) | 2017-08-31 | 2017-08-31 | A kind of insect-expelling saligna injection liquid handles filling process |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107651644A (en) |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0579480A1 (en) * | 1992-07-14 | 1994-01-19 | Eisai Co., Ltd. | Filling/sealing apparatus for ampule or the like and method for monitoring this apparatus |
| DE10028823C2 (en) * | 2000-06-10 | 2002-05-29 | Vetter & Co Apotheker | Method and device for filling, freeze-drying and closing pre-filled syringes |
| CA2516766A1 (en) * | 2003-02-25 | 2004-09-10 | Glaxosmithkline Biologicals S.A. | Apparatus and process for filling a medicament into a container |
| CN101658490A (en) * | 2008-08-25 | 2010-03-03 | 西安博森生物制药有限责任公司 | Preparation method of ropivacaine mesylate injection packed by soda-lime glass bottle |
| CN102008433A (en) * | 2010-12-01 | 2011-04-13 | 广东三信药业有限公司 | Fasudil salt injection for improving stability and preparation method thereof |
| CN102874422A (en) * | 2012-10-31 | 2013-01-16 | 山东威高集团医用高分子制品股份有限公司 | Production technology of honeycomb type packaging pre-filling sealing penicillin bottle |
| CN103964006A (en) * | 2014-05-07 | 2014-08-06 | 湖南科伦制药有限公司 | Drug liquid filling method |
| CN105832659A (en) * | 2016-04-29 | 2016-08-10 | 芜湖杨燕制药有限公司 | Production technology of traditional Chinese medicine injection |
-
2017
- 2017-08-31 CN CN201710767605.7A patent/CN107651644A/en active Pending
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0579480A1 (en) * | 1992-07-14 | 1994-01-19 | Eisai Co., Ltd. | Filling/sealing apparatus for ampule or the like and method for monitoring this apparatus |
| DE10028823C2 (en) * | 2000-06-10 | 2002-05-29 | Vetter & Co Apotheker | Method and device for filling, freeze-drying and closing pre-filled syringes |
| CA2516766A1 (en) * | 2003-02-25 | 2004-09-10 | Glaxosmithkline Biologicals S.A. | Apparatus and process for filling a medicament into a container |
| CN101658490A (en) * | 2008-08-25 | 2010-03-03 | 西安博森生物制药有限责任公司 | Preparation method of ropivacaine mesylate injection packed by soda-lime glass bottle |
| CN102008433A (en) * | 2010-12-01 | 2011-04-13 | 广东三信药业有限公司 | Fasudil salt injection for improving stability and preparation method thereof |
| CN102874422A (en) * | 2012-10-31 | 2013-01-16 | 山东威高集团医用高分子制品股份有限公司 | Production technology of honeycomb type packaging pre-filling sealing penicillin bottle |
| CN103964006A (en) * | 2014-05-07 | 2014-08-06 | 湖南科伦制药有限公司 | Drug liquid filling method |
| CN105832659A (en) * | 2016-04-29 | 2016-08-10 | 芜湖杨燕制药有限公司 | Production technology of traditional Chinese medicine injection |
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| PB01 | Publication | ||
| PB01 | Publication | ||
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| RJ01 | Rejection of invention patent application after publication | ||
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Application publication date: 20180202 |