CN103961335A - Pulullan soft capsule and preparation method thereof - Google Patents
Pulullan soft capsule and preparation method thereof Download PDFInfo
- Publication number
- CN103961335A CN103961335A CN201410218210.8A CN201410218210A CN103961335A CN 103961335 A CN103961335 A CN 103961335A CN 201410218210 A CN201410218210 A CN 201410218210A CN 103961335 A CN103961335 A CN 103961335A
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- soft capsule
- pulullan polysaccharide
- pulullan
- capsule
- preparation
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- 239000007901 soft capsule Substances 0.000 title claims abstract description 36
- 238000002360 preparation method Methods 0.000 title claims abstract description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 17
- 239000006184 cosolvent Substances 0.000 claims abstract description 10
- 239000003995 emulsifying agent Substances 0.000 claims abstract description 10
- 239000004014 plasticizer Substances 0.000 claims abstract description 10
- 150000004676 glycans Chemical class 0.000 claims description 37
- 229920001282 polysaccharide Polymers 0.000 claims description 37
- 239000005017 polysaccharide Substances 0.000 claims description 37
- PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerol group Chemical group OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 36
- 239000003292 glue Substances 0.000 claims description 22
- 238000003756 stirring Methods 0.000 claims description 14
- ZTOKUMPYMPKCFX-CZNUEWPDSA-N (E)-17-[(2R,3R,4S,5S,6R)-6-(acetyloxymethyl)-3-[(2S,3R,4S,5S,6R)-6-(acetyloxymethyl)-3,4,5-trihydroxyoxan-2-yl]oxy-4,5-dihydroxyoxan-2-yl]oxyoctadec-9-enoic acid Chemical group OC(=O)CCCCCCC/C=C/CCCCCCC(C)O[C@@H]1O[C@H](COC(C)=O)[C@@H](O)[C@H](O)[C@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](COC(C)=O)O1 ZTOKUMPYMPKCFX-CZNUEWPDSA-N 0.000 claims description 12
- BCZXFFBUYPCTSJ-UHFFFAOYSA-L Calcium propionate Chemical group [Ca+2].CCC([O-])=O.CCC([O-])=O BCZXFFBUYPCTSJ-UHFFFAOYSA-L 0.000 claims description 12
- 235000010331 calcium propionate Nutrition 0.000 claims description 12
- 239000004330 calcium propionate Substances 0.000 claims description 12
- 238000010438 heat treatment Methods 0.000 claims description 6
- 238000002156 mixing Methods 0.000 claims description 6
- 239000008188 pellet Substances 0.000 claims description 6
- 239000000679 carrageenan Substances 0.000 claims description 4
- 235000010418 carrageenan Nutrition 0.000 claims description 4
- 229920001525 carrageenan Polymers 0.000 claims description 4
- 229940113118 carrageenan Drugs 0.000 claims description 4
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 claims description 4
- 230000015572 biosynthetic process Effects 0.000 claims description 2
- 239000002775 capsule Substances 0.000 abstract description 20
- 239000003814 drug Substances 0.000 abstract description 13
- 229920000159 gelatin Polymers 0.000 abstract description 9
- 235000019322 gelatine Nutrition 0.000 abstract description 9
- 239000002994 raw material Substances 0.000 abstract description 8
- 238000011049 filling Methods 0.000 abstract description 5
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract description 3
- 230000008901 benefit Effects 0.000 abstract description 3
- 229940079593 drug Drugs 0.000 abstract description 3
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 abstract description 3
- 229910052760 oxygen Inorganic materials 0.000 abstract description 3
- 239000001301 oxygen Substances 0.000 abstract description 3
- 239000001828 Gelatine Substances 0.000 abstract description 2
- 230000004888 barrier function Effects 0.000 abstract description 2
- 230000007062 hydrolysis Effects 0.000 abstract description 2
- 238000006460 hydrolysis reaction Methods 0.000 abstract description 2
- 235000021120 animal protein Nutrition 0.000 abstract 1
- 230000035939 shock Effects 0.000 abstract 1
- 108010010803 Gelatin Proteins 0.000 description 7
- 239000008273 gelatin Substances 0.000 description 7
- 235000011852 gelatine desserts Nutrition 0.000 description 7
- 239000000499 gel Substances 0.000 description 6
- 235000019737 Animal fat Nutrition 0.000 description 2
- 208000007212 Foot-and-Mouth Disease Diseases 0.000 description 2
- 241000710198 Foot-and-mouth disease virus Species 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 208000018756 Variant Creutzfeldt-Jakob disease Diseases 0.000 description 2
- 208000005881 bovine spongiform encephalopathy Diseases 0.000 description 2
- 150000001768 cations Chemical class 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 240000008067 Cucumis sativus Species 0.000 description 1
- 235000010799 Cucumis sativus var sativus Nutrition 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 206010023126 Jaundice Diseases 0.000 description 1
- 108091005804 Peptidases Proteins 0.000 description 1
- 239000004365 Protease Substances 0.000 description 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 229920006318 anionic polymer Polymers 0.000 description 1
- 230000008827 biological function Effects 0.000 description 1
- 229920006317 cationic polymer Polymers 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000000084 colloidal system Substances 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 238000005336 cracking Methods 0.000 description 1
- 230000007850 degeneration Effects 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 239000007902 hard capsule Substances 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 239000003595 mist Substances 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 239000011505 plaster Substances 0.000 description 1
- 150000008442 polyphenolic compounds Chemical class 0.000 description 1
- 235000013824 polyphenols Nutrition 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
Abstract
The invention discloses a Pulullan soft capsule and a preparation method thereof. The Pulullan soft capsule is prepared from the following components in percentage by weight: 20-60% of Pulullan, 0.15-2% of gelatinizer, 15-30% of plasticizer, 0.02-0.8% of emulsifier, 0.03-0.3% of cosolvent and 22-63% of water. The Pulullan soft capsule has the advantages of higher oxygen barrier property, higher shock strength, stable quality, low tendency to crushing, stable disintegration index and low tendency to hydrolysis, and can not easily produce fog or become yellow on the surface after long-time placement. The raw materials are from pure plants, thereby completely avoiding pollutions which can be caused by animal proteins. The capsule has lower water content than the gelatine capsule, is more suitable for filling hydroscopic drugs and aldehyde-containing drugs, and has wide market prospects and practical value.
Description
Technical field
The present invention relates to a kind of capsule technique field, relate in particular to a kind of take pulullan polysaccharide soft capsule that pulullan polysaccharide is primary raw material and the preparation method of this soft capsule.
Background technology
Soft capsule is a kind of novel form capsule growing up in fields such as medicine, food, health product, cosmetics in recent years, it is by the quantitative pressure injection of packed article and is encapsulated in rubber, form seal capsule, there is the advantages such as content is accurate, good uniformity, good looking appearance.
But as the rubber of soft capsule, be to be all used as major ingredient gel with gelatin at present substantially.The hard capsule water content of preparing with gelatin has certain limit (12. 5%～17.5%), as lower than this scope, the friability of capsule increases, be unfavorable for the filling of medicine, for easy hygroscopicity medicine (some Chinese herbal medicine), the moisture of capsule is easily filled with thing and draws, and the medicine that filling is good easily splits at storage life capsule; In addition, for unsettled medicine after moisture absorption, also affected expiration date of drug, gelatin can with Cucumber generation crosslinked action, as aldehyde, polyphenol, reducing sugar, multi-charge cation, electrolyte, cation or anionic polymer etc., thereby capsule mechanical performance or biological function are changed; Gelatin not only can be hydrolyzed by protease cracking and strong acid, also can cause degeneration because of highly basic.Therefore,, during filling liquid medicine, pH should be controlled at 4.5～7.5.
The soft capsule of preparing with gelatin and the medicine of capsule will have certain constant-temperature constant-humidity environment to store, because of excess Temperature, and the easy softening transform of capsule, temperature is too low, the easy embrittlement of capsule.Gelatin is animal proteinum colloid, and contains certain Animal fat, and in general gelatin, Animal fat content is approximately 2. 2%, easily causes pollution (foot and mouth disease, bovine spongiform encephalopathy etc.), and these shortcomings have restricted applying of soft capsule products.
Summary of the invention
Technical problem to be solved by this invention is to provide that a kind of disintegration rate is fast, friability is better, appearance is glittering and translucent, oxygen permeability is low, storage time is long, and all raw materials are the biological pulullan polysaccharide soft capsule of preparing without any artificial synthetic ingredient, also provide the preparation method of this pulullan polysaccharide soft capsule simultaneously.
For solving the problems of the technologies described above, technical scheme of the present invention is:
Pulullan polysaccharide soft capsule, makes by comprising following percentage by weight component: pulullan polysaccharide 20～60%, gel 0.15～2%, plasticizer 15～30%, emulsifying agent 0.02～0.8%, cosolvent 0.03～0.3%, water 22～63%.
As preferably, described gel is carrageenan;
As preferably, described plasticizer is glycerol;
As preferably, described emulsifying agent is sophorolipid;
As preferably, described cosolvent is calcium propionate;
The present invention also provides the preparation method of above-mentioned pulullan polysaccharide soft capsule, comprises the following steps:
(1) by the water of percentage by weight 22～63%, add can the heating and stirring tank of evacuation in, allow blender with the speed running of 30～50 revs/min;
(2) percentage by weight is respectively to pulullan polysaccharide 20～60%, gel 0.15～2%, plasticizer 15～30%, emulsifying agent 0.02～0.8%, cosolvent 0.03～0.3%, put into respectively in tank, after feeding intake, mixing speed is adjusted to 50～80 revs/min, each component is stirred to mix homogeneously and dissolves formation glue completely;
(3) temperature in tank is risen to 60～95 ℃, with the speed of 30～50 revs/min, stir, keep 0.5～3 hour;
(4) speed continuing with 30～50 revs/min stirs, and evacuation is eliminated the bubble in glue simultaneously;
(5) glue is made to strip film with mould; And film is rested on to 35～75 ℃ of temperature, and in the environment of humidity 20～70%, standing 2～36 hours;
(6) described film is sent into soft capsule pellet press pelleting, made finished product.
As preferably, described gel is carrageenan; Described plasticizer is glycerol; Described emulsifying agent is sophorolipid; Described cosolvent is calcium propionate.
Owing to having adopted technique scheme, pulullan polysaccharide soft capsule, makes by comprising following percentage by weight component: pulullan polysaccharide 20～60%, gel 0.15～2%, plasticizer 15～30%, emulsifying agent 0.02～0.8%, cosolvent 0.03～0.3%, water 22～63%; The present invention adopts pulullan polysaccharide as material of main part, because pulullan polysaccharide molecule is regular, the change of molecular weight scope is little, product quality is easily controlled, and has higher oxygen barrier and impact strength, and quality stability is good, be difficult for friability, slaking index is stable, facile hydrolysis not, and long-time placement surface is not sent out mist jaundice; Raw material used is pure plant origin, can avoid the pollution (foot and mouth disease, bovine spongiform encephalopathy etc.) because animal proteinum may cause completely.This capsule can be filled lipophile liquid, semisolid and plaster material, and especially all the components of this capsule is all that biological fermentation process is produced, and meets the medicine requirement of Arab countries.This capsule water content, lower than gelatine capsule, is more easily applicable to filling hygroscopicity medicine and aldehyde-containing type medicine, has market prospect and practical value widely.
The specific embodiment
Below in conjunction with specific embodiment, the present invention is described further:
embodiment 1:
First, prepare following raw material: pulullan polysaccharide 2000g, Wei Lan glue 200g, glycerol 1500g, sophorolipid 2g, calcium propionate 3g, water 6500g.
Then, prepare according to the following steps capsule: (1) 6300g water add can the heating and stirring tank of evacuation in, allow the speed running of blender with 50 turn/min; (2) by pulullan polysaccharide 2000g, Wei Lan glue 200g, glycerol 1500g, sophorolipid 2g, calcium propionate 3g puts into respectively in tank, after feeding intake, mixing speed is adjusted to 80 turn/min, and each component is stirred to mix homogeneously and dissolves completely; (3) open heater switch, temperature in tank is risen to 60 ℃, keep 0.5h; (4) speed with 30 turn/min stirs, and evacuation is eliminated the bubble in glue simultaneously; (5) glue is made to strip film with mould; (6) film is rested on to 75 ℃, in the environment of humidity 20%, standing 36 hours; (7) the above-mentioned film making is sent into soft capsule pellet press pelleting, obtain pulullan polysaccharide soft capsule.
embodiment 2:
First, prepare following raw material: pulullan polysaccharide 6000g, Wei Lan glue 200g, glycerol 1500g, sophorolipid 80g, calcium propionate 30g, water 2500g.
Then, prepare according to the following steps capsule: (1) 2200g water add can the heating and stirring tank of evacuation in, allow the speed running of blender with 30 turn/min; (2) by pulullan polysaccharide 6000g, Wei Lan glue 200g, glycerol 1500g, sophorolipid 80g, calcium propionate 30g puts into respectively in tank, after feeding intake, mixing speed is adjusted to 50 turn/min, and each component is stirred to mix homogeneously and dissolves completely; (3) open heater switch, temperature in tank is risen to 75 ℃, keep 3h; (4) speed with 30 turn/min stirs, and evacuation is eliminated the bubble in glue simultaneously; (5) glue is made to strip film with mould; (6) film is rested on to 35 ℃, in the environment of humidity 70%, standing 36 hours; (7) the above-mentioned film making is sent into soft capsule pellet press pelleting, obtain pulullan polysaccharide soft capsule.
embodiment 3:
First, prepare following raw material: pulullan polysaccharide 4000g, Wei Lan glue 15g, glycerol 3000g, sophorolipid 60g, calcium propionate 10g, water 3000g.
Then, prepare according to the following steps capsule: (1) 3000g water add can the heating and stirring tank of evacuation in, allow the speed running of blender with 30 turn/min; (2) by pulullan polysaccharide 4000g, Wei Lan glue 15g, glycerol 3000g, sophorolipid 60g, calcium propionate 10g puts into respectively in tank, after feeding intake, mixing speed is adjusted to 50 turn/min, and each component is stirred to mix homogeneously and dissolves completely; (3) open heater switch, temperature in tank is risen to 95 ℃, keep 1h; (4) speed with 30 turn/min stirs, and evacuation is eliminated the bubble in glue simultaneously; (5) glue is made to strip film with mould; (6) film is rested on to 55 ℃, in the environment of humidity 20%, standing 30 hours; (7) the above-mentioned film making is sent into soft capsule pellet press pelleting, obtain pulullan polysaccharide soft capsule.
embodiment 4:
First, prepare following raw material: pulullan polysaccharide 3000g, Wei Lan glue 50g, glycerol 3000g, sophorolipid 50g, calcium propionate 10g, water 4000g.
Then, prepare according to the following steps capsule: (1) 4000g water add can the heating and stirring tank of evacuation in, allow the speed running of blender with 50 turn/min; (2) by pulullan polysaccharide 3000g, Wei Lan glue 50g, glycerol 3000g, sophorolipid 50g, calcium propionate 10g puts into respectively in tank, after feeding intake, mixing speed is adjusted to 60 turn/min, and each component is stirred to mix homogeneously and dissolves completely; (3) open heater switch, temperature in tank is risen to 60 ℃, keep 1.5h; (4) speed with 40 turn/min stirs, and evacuation is eliminated the bubble in glue simultaneously; (5) glue is made to strip film with mould; (6) film is rested on to 65 ℃, in the environment of humidity 40%, standing 18 hours; (7) the above-mentioned film making is sent into soft capsule pellet press pelleting, obtain pulullan polysaccharide soft capsule.
More than show and described ultimate principle of the present invention, principal character and advantage of the present invention.The technical staff of the industry should understand; the present invention is not restricted to the described embodiments; that in above-described embodiment and description, describes just illustrates principle of the present invention; without departing from the spirit and scope of the present invention; the present invention also has various changes and modifications, and these changes and improvements all fall in the claimed scope of the invention.The claimed scope of the present invention is defined by appending claims and equivalent thereof.
Claims (10)
1. pulullan polysaccharide soft capsule, is characterized in that, makes: pulullan polysaccharide 20～60%, gel 0.15～2%, plasticizer 15～30%, emulsifying agent 0.02～0.8%, cosolvent 0.03～0.3%, water 22～63% by comprising following percentage by weight component.
2. pulullan polysaccharide soft capsule as claimed in claim 1, is characterized in that, described gel is carrageenan.
3. pulullan polysaccharide soft capsule as claimed in claim 1, is characterized in that, described plasticizer is glycerol.
4. pulullan polysaccharide soft capsule as claimed in claim 1, is characterized in that, described emulsifying agent is sophorolipid.
5. pulullan polysaccharide soft capsule as claimed in claim 1, is characterized in that, described cosolvent is calcium propionate.
6. the preparation method of pulullan polysaccharide soft capsule as claimed in claim 1, is characterized in that, comprises the following steps:
(1) by the water of percentage by weight 22～63%, add can the heating and stirring tank of evacuation in, allow blender with the speed running of 30～50 revs/min;
(2) percentage by weight is respectively to pulullan polysaccharide 20～60%, gel 0.15～2%, plasticizer 15～30%, emulsifying agent 0.02～0.8%, cosolvent 0.03～0.3%, put into respectively in tank, after feeding intake, mixing speed is adjusted to 50～80 revs/min, each component is stirred to mix homogeneously and dissolves formation glue completely;
(3) temperature in tank is risen to 60～95 ℃, with the speed of 30～50 revs/min, stir, keep 0.5～3 hour;
(4) speed continuing with 30～50 revs/min stirs, and evacuation is eliminated the bubble in glue simultaneously;
(5) glue is made to strip film with mould; And film is rested on to 35～75 ℃ of temperature, and in the environment of humidity 20～70%, standing 2～36 hours;
(6) described film is sent into soft capsule pellet press pelleting, made finished product.
7. the preparation method of pulullan polysaccharide soft capsule as claimed in claim 6, is characterized in that, described gel is carrageenan.
8. the preparation method of pulullan polysaccharide soft capsule as claimed in claim 6, is characterized in that, described plasticizer is glycerol.
9. the preparation method of pulullan polysaccharide soft capsule as claimed in claim 6, is characterized in that, described emulsifying agent is sophorolipid.
10. the preparation method of pulullan polysaccharide soft capsule as claimed in claim 6, is characterized in that, described cosolvent is calcium propionate.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410218210.8A CN103961335B (en) | 2014-05-22 | 2014-05-22 | Pulullan polysaccharide soft capsule and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201410218210.8A CN103961335B (en) | 2014-05-22 | 2014-05-22 | Pulullan polysaccharide soft capsule and preparation method thereof |
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| Publication Number | Publication Date |
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| CN103961335A true CN103961335A (en) | 2014-08-06 |
| CN103961335B CN103961335B (en) | 2016-01-13 |
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| CN201410218210.8A Expired - Fee Related CN103961335B (en) | 2014-05-22 | 2014-05-22 | Pulullan polysaccharide soft capsule and preparation method thereof |
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104436204A (en) * | 2014-12-05 | 2015-03-25 | 通辽梅花生物科技有限公司 | Pullulan polysaccharide capsule and preparation process thereof |
| CN105363038A (en) * | 2014-09-01 | 2016-03-02 | 天津宏顺科生物科技有限公司 | Preparation method of pulullan soft capsule |
| CN106723290A (en) * | 2017-03-31 | 2017-05-31 | 江苏中烟工业有限责任公司 | It is a kind of based on tobacco protein, the microcapsule preparation method of tobacco polysaccharide gel and application |
| CN109260171A (en) * | 2018-10-12 | 2019-01-25 | 江苏力凡胶囊有限公司 | A kind of preparation method of the pulullan polysaccharide capsule of stable disintegration |
| CN109568154A (en) * | 2018-12-28 | 2019-04-05 | 北京航洋健康科技有限公司 | A kind of capsule housing and the fragrant soft capsule of lock prepared therefrom and preparation method thereof |
| CN112891316A (en) * | 2021-02-01 | 2021-06-04 | 吉林万通药业有限公司 | Vitamin E soft capsule and preparation method thereof |
| CN114028357A (en) * | 2021-09-28 | 2022-02-11 | 山东弥美生物科技股份有限公司 | Pullulan soft capsule and preparation method thereof |
| US11319566B2 (en) | 2017-04-14 | 2022-05-03 | Capsugel Belgium Nv | Process for making pullulan |
| US11576870B2 (en) | 2017-04-14 | 2023-02-14 | Capsugel Belgium Nv | Pullulan capsules |
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Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105363038A (en) * | 2014-09-01 | 2016-03-02 | 天津宏顺科生物科技有限公司 | Preparation method of pulullan soft capsule |
| CN104436204A (en) * | 2014-12-05 | 2015-03-25 | 通辽梅花生物科技有限公司 | Pullulan polysaccharide capsule and preparation process thereof |
| CN106723290A (en) * | 2017-03-31 | 2017-05-31 | 江苏中烟工业有限责任公司 | It is a kind of based on tobacco protein, the microcapsule preparation method of tobacco polysaccharide gel and application |
| CN106723290B (en) * | 2017-03-31 | 2018-09-21 | 江苏中烟工业有限责任公司 | It is a kind of based on tobacco protein, the microcapsule preparation method of tobacco polysaccharide gel and application |
| US11319566B2 (en) | 2017-04-14 | 2022-05-03 | Capsugel Belgium Nv | Process for making pullulan |
| US11576870B2 (en) | 2017-04-14 | 2023-02-14 | Capsugel Belgium Nv | Pullulan capsules |
| US11878079B2 (en) | 2017-04-14 | 2024-01-23 | Capsugel Belgium Nv | Pullulan capsules |
| CN109260171A (en) * | 2018-10-12 | 2019-01-25 | 江苏力凡胶囊有限公司 | A kind of preparation method of the pulullan polysaccharide capsule of stable disintegration |
| CN109568154A (en) * | 2018-12-28 | 2019-04-05 | 北京航洋健康科技有限公司 | A kind of capsule housing and the fragrant soft capsule of lock prepared therefrom and preparation method thereof |
| CN112891316A (en) * | 2021-02-01 | 2021-06-04 | 吉林万通药业有限公司 | Vitamin E soft capsule and preparation method thereof |
| CN114028357A (en) * | 2021-09-28 | 2022-02-11 | 山东弥美生物科技股份有限公司 | Pullulan soft capsule and preparation method thereof |
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| Publication number | Publication date |
|---|---|
| CN103961335B (en) | 2016-01-13 |
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