CN103957706A - 雌激素受体配体以及其使用方法 - Google Patents

雌激素受体配体以及其使用方法 Download PDF

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Publication number
CN103957706A
CN103957706A CN201280051979.4A CN201280051979A CN103957706A CN 103957706 A CN103957706 A CN 103957706A CN 201280051979 A CN201280051979 A CN 201280051979A CN 103957706 A CN103957706 A CN 103957706A
Authority
CN
China
Prior art keywords
compound
another embodiment
prostate cancer
formula
castration
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201280051979.4A
Other languages
English (en)
Chinese (zh)
Inventor
J·多尔顿
M·S·斯坦纳
C·C·科斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Oncternal Therapeutics Inc
Original Assignee
GTx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US13/215,679 external-priority patent/US9427418B2/en
Application filed by GTx Inc filed Critical GTx Inc
Priority claimed from PCT/US2012/052141 external-priority patent/WO2013043304A1/en
Publication of CN103957706A publication Critical patent/CN103957706A/zh
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4453—Non condensed piperidines, e.g. piperocaine only substituted in position 1, e.g. propipocaine, diperodon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
CN201280051979.4A 2011-08-23 2012-08-23 雌激素受体配体以及其使用方法 Pending CN103957706A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13/215,679 2011-08-23
US13/215,679 US9427418B2 (en) 2009-02-23 2011-08-23 Estrogen receptor ligands and methods of use thereof
PCT/US2012/052141 WO2013043304A1 (en) 2009-02-23 2012-08-23 Estrogen receptor ligands and methods of use thereof

Publications (1)

Publication Number Publication Date
CN103957706A true CN103957706A (zh) 2014-07-30

Family

ID=48444651

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201280051979.4A Pending CN103957706A (zh) 2011-08-23 2012-08-23 雌激素受体配体以及其使用方法

Country Status (10)

Country Link
EP (1) EP2747562A4 (https=)
JP (1) JP2014524479A (https=)
KR (1) KR20140064906A (https=)
CN (1) CN103957706A (https=)
AU (1) AU2012312902B2 (https=)
CA (1) CA2845890A1 (https=)
IL (1) IL231070A0 (https=)
IN (1) IN2014DN01959A (https=)
MX (1) MX2014002105A (https=)
RU (1) RU2014111060A (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113365623A (zh) * 2019-01-30 2021-09-07 阿拉贡药品公司 用于治疗转移性去势敏感性前列腺癌的抗雄激素
CN113853216A (zh) * 2019-02-01 2021-12-28 肿瘤学研究所基金会(Ior) 治疗去势抵抗性前列腺癌的方法

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2020535171A (ja) * 2017-09-27 2020-12-03 ターグイミューン セラピューティクス アーゲー 去勢抵抗性前立腺癌

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101336227A (zh) * 2005-11-28 2008-12-31 Gtx公司 核受体结合剂
WO2010096801A1 (en) * 2009-02-23 2010-08-26 Gtx, Inc. Estrogen receptor ligands and methods of use thereof
US20100267773A1 (en) * 2005-11-28 2010-10-21 Dalton James T Estrogen receptor ligands and methods of use thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8158828B2 (en) * 2005-11-28 2012-04-17 Gtx, Inc. Nuclear receptor binding agents

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101336227A (zh) * 2005-11-28 2008-12-31 Gtx公司 核受体结合剂
US20100267773A1 (en) * 2005-11-28 2010-10-21 Dalton James T Estrogen receptor ligands and methods of use thereof
WO2010096801A1 (en) * 2009-02-23 2010-08-26 Gtx, Inc. Estrogen receptor ligands and methods of use thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
GTX: "GTx-758 on serum prostare-specific antigen(PSA) in men with castrate resistant prostate cancer", 《URL:HTTP://CLINICALTRIALS.GOV/ARCHIVE/NCT01420861/2011_08_19》 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113365623A (zh) * 2019-01-30 2021-09-07 阿拉贡药品公司 用于治疗转移性去势敏感性前列腺癌的抗雄激素
CN113853216A (zh) * 2019-02-01 2021-12-28 肿瘤学研究所基金会(Ior) 治疗去势抵抗性前列腺癌的方法

Also Published As

Publication number Publication date
IL231070A0 (en) 2014-03-31
AU2012312902B2 (en) 2016-03-17
JP2014524479A (ja) 2014-09-22
KR20140064906A (ko) 2014-05-28
MX2014002105A (es) 2014-09-25
AU2012312902A1 (en) 2013-05-23
RU2014111060A (ru) 2015-09-27
EP2747562A1 (en) 2014-07-02
EP2747562A4 (en) 2015-05-06
CA2845890A1 (en) 2013-03-28
IN2014DN01959A (https=) 2015-05-15

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PB01 Publication
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Effective date of abandoning: 20170609