CN103954699A - Detection device for gas chromatograph-mass spectrometer - Google Patents
Detection device for gas chromatograph-mass spectrometer Download PDFInfo
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- CN103954699A CN103954699A CN201410140485.4A CN201410140485A CN103954699A CN 103954699 A CN103954699 A CN 103954699A CN 201410140485 A CN201410140485 A CN 201410140485A CN 103954699 A CN103954699 A CN 103954699A
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Abstract
The invention relates to a detection device for gas chromatograph-mass spectrometer, which comprises electrodes and detectors, and is characterized in that the electrodes are two electrodes arranged oppositely; the detectors are two detectors disposed behind the two electrodes; ions deflect between the two electrodes under the action of an electric field to enter corresponding detectors. The detection device of the invention has the advantages of good detection compatibility for positive and negative ions, wide dynamic scope and the like.
Description
Technical field
The present invention relates to a kind of pick-up unit, especially a kind of chromatograph-mass spectrometer pick-up unit.
Background technology
Liquid chromatography mass combined instrument adopts single detector configurations more at present, when carrying out negative ions change detection, need to carry out the positive and negative switching of electron spray high voltage and detector voltage, and the switching of detector voltage is the principal element that affects switch speed, detector voltage is generally thousands of volts left and right, stabilization time that need to be longer while carrying out positive-negative polarity switching, can greatly affect the detection speed of instrument like this, under single detector configurations, minimizing negative ions detects needs high-voltage power supply and the complicated circuit design that stability in use is higher switching time, increase the cost of instrument.In addition under single detector configurations, detecting device counting mode is simulation counting or step-by-step counting, simulation counting mode is generally used for sample concentration when higher, and pulse-counter detector is generally used for sample concentration when lower, so the dynamic range of instrument is affected under single detector configurations.
Summary of the invention
In order to solve above-mentioned deficiency of the prior art, the invention provides a kind of chromatograph-mass spectrometer pick-up unit without electrode and the switching of detector voltage polarity.
For achieving the above object, the present invention adopts following technical scheme:
A kind of chromatograph-mass spectrometer pick-up unit, comprise electrode and detecting device, be characterized in: described electrode is two plate electrodes staggered relatively, described detecting device is two detecting devices that are arranged on after described two plate electrodes, and ion deflects and enters corresponding detecting device under the electric field action between two plate electrodes.
Further, described two detecting devices apply respectively the voltage of opposite polarity, so that the ion of opposed polarity enters corresponding detecting device after the electric deflection between two plate electrodes.
Further, the described two plate electrodes placement that is parallel to each other.
As preferably, described electrode is square-shaped electrode or cylindrical electrode.
As preferably, described two plate electrodes are identical.
Further, described two detecting devices are arranged on the perpendicular bisector both sides of described two place, plate electrode center line segments.
Further, described two detecting devices are oppositely arranged.
As preferably, described ion enters the electric field between described two plate electrodes along the perpendicular bisector of described two place, plate electrode center line segments.
Further, one of them is simulation count detector for described two detecting devices, and another is pulse-counter detector.
The present invention compared with prior art has following beneficial effect:
1, negative ions detection is compatible good
The present invention adopts electrode and dual-detector configuration, makes chromatograph-mass spectrometer when carrying out negative ions change detection, without the polarity of deflecting electrode and detector voltage is switched, can greatly reduce the switching time that negative ions detects.
2, wide dynamic range
Dual-detector can be configured to a simulation count detector and a pulse-counter detector, under the effect of electrode, in the time of need to simulating count detection, ion beam is deflected and enters simulation count detector, in the time of need to carrying out step-by-step counting detection, ion beam is deflected and enters pulse-counter detector, so just can realize the double mode detection of analog pulse, improve the detection dynamic range of instrument.
Accompanying drawing explanation
Fig. 1 is chromatograph-mass spectrometer structure of the detecting device schematic diagram in embodiment 2;
The result schematic diagram of Fig. 2 for the chromatograph-mass spectrometer pick-up unit in embodiment 2 is carried out to emulation;
The result schematic diagram of Fig. 3 for the chromatograph-mass spectrometer pick-up unit in embodiment 3 is carried out to emulation;
Fig. 4 is the three-dimensional ion-optical simulation result schematic diagram of the cylindrical electrode based in Fig. 3;
Fig. 5 is chromatograph-mass spectrometer structure of the detecting device schematic diagram in embodiment 4.
Embodiment
Embodiment 1
A kind of chromatograph-mass spectrometer pick-up unit, comprise electrode and detecting device, described electrode is two plate electrodes staggered relatively, and described detecting device is two detecting devices that are arranged on after described two plate electrodes, and ion deflects and enters corresponding detecting device under the electric field action between two plate electrodes.
Further, described two detecting devices apply respectively the voltage of opposite polarity, so that the ion of opposed polarity enters corresponding detecting device after the electric deflection between two plate electrodes.
Further, the described two plate electrodes placement that is parallel to each other.
As preferably, described electrode is square-shaped electrode or cylindrical electrode.
As preferably, described two plate electrodes are identical.
Further, described two detecting devices are arranged on the perpendicular bisector both sides of described two place, plate electrode center line segments.
Further, described two detecting devices are oppositely arranged.
As preferably, described ion enters the electric field between described two plate electrodes along the perpendicular bisector of described two place, plate electrode center line segments.
Further, one of them is simulation count detector for described two detecting devices, and another is pulse-counter detector.
The present invention adopts electrode and dual-detector configuration, makes chromatograph-mass spectrometer when carrying out negative ions change detection, without the polarity of deflecting electrode and detector voltage is switched, can greatly reduce the switching time that negative ions detects.
Embodiment 2
The present embodiment is the application examples of embodiment 1.
Figure 1 shows that chromatograph-mass spectrometer structure of the detecting device schematic diagram when negative ions detects, by two identical square-shaped electrode 11, parallel placement forms kind electrode with electrode 12, electrode length of a film is 4mm, width 8mm, thickness 1mm, two plate electrode spacing 4mm, electrode 11 loads positive voltage (approximately several volts, suitable with incident ionic energy), electrode 12 loads zero potential or negative voltage (approximately several volts, suitable with incident ionic energy).
Should use-case, after detecting device 101 and detecting device 102 are arranged on electrode 11 and electrode 12 and be oppositely arranged, and detecting device 101 and detecting device 102 are arranged on the perpendicular bisector both sides of electrode 11 and place, electrode 12 get center line segment.
In reality detects, the voltage of electrode 11 and electrode 12 electrodes and detecting device 101 and detecting device 102 does not all need to carry out polarity of voltage switching, voltage swing does not need to change yet, in Fig. 1, (a) is positive ion detecting pattern schematic diagram, now positive ion enters detecting device 102 and detects under the effect of electrode, in Fig. 1, (b) is positive ion detecting pattern schematic diagram, and now negative ion enters detecting device 101 and detects under the effect of electrode.In this chromatograph-mass spectrometer pick-up unit, the design of electrode is crucial, the high pressure of two detecting devices (thousands of volt) one positive one is negatively opened simultaneously, under positive ion mode, deflecting electrode is partial to positive ion detecting device by ion, under negative ion mode, deflecting electrode is partial to negative ion detector by ion, and negative ions detecting device does not affect mutually.
What Fig. 2 showed is to use the simulation result schematic diagram of ion-optical simulation software to the present embodiment chromatograph-mass spectrometer pick-up unit, in emulation, incident ion beam energy is 5eV, electrode 12 loading+3V voltages, electrode 11 loads zero potential, detecting device 101 voltages are+1000V, detecting device 102 voltages are-1000V, simulation result can find out that negative ions is partial to respectively two detecting devices, does not interfere with each other.
Embodiment 3
The present embodiment is the application examples of embodiment 1.
What Fig. 3 showed is to use the simulation result schematic diagram of ion-optical simulation software to the present embodiment chromatograph-mass spectrometer pick-up unit, what the electrode of the present embodiment adopted is two identical cylindrical electrodes 21 and electrode 22, cylindrical radius 2mm, height 6mm, two cylinder centers of circle are at a distance of 6mm.
What Fig. 4 showed is the three-dimensional ion-optical simulation result of the cylindrical electrode based in Fig. 3.Electrode 21 loading+4V voltages in emulation experiment, electrode 22 loads zero potentials, and detecting device 101 voltages be+1000V, detecting device 102 voltages be-1000V, and simulation result can find out that negative ions is partial to respectively two detecting devices, does not interfere with each other.
The design of electrode size is crucial, deflecting electrode is long, the deflected trajectory of ion lengthens, easily collide to death on electrode, electrode is too short, and the high pressure on detecting device can affect ion and enter electrode track before, thereby can not complete effective deflection, the size of electrode is determined by emulation experiment, finely tunes by experiment.
Embodiment 4
The present embodiment is the application examples of embodiment 1.
Chromatograph-mass spectrometer structure of the detecting device schematic diagram during the double mode detection of Fig. 5 display simulation pulse, electrode can adopt the electrode of design in embodiment 2 or embodiment 3, and the electrode of the present embodiment adopts the electrode of design in embodiment 2.Detecting device 401 is pulse-counter detector, and detecting device 402 is simulation count detector.
In double mode detection, the effect of electrode is that ion deflecting is entered to suitable detecting device, Fig. 5 (a) is simulation count detection pattern diagram, now ion enters detecting device 402 and samples under the effect of electrode, Fig. 5 (b) is step-by-step counting detecting pattern schematic diagram, and now ion enters detecting device 401 and samples under the effect of electrode.The voltage setting that this design need to change electrode is that the polarity of voltage of electrode is to enter ion deflecting suitable detecting device.
Dual-detector can be configured to a simulation count detector and a pulse-counter detector, under the effect of electrode, in the time of need to simulating count detection, ion beam is deflected and enters simulation count detector, in the time of need to carrying out step-by-step counting detection, ion beam is deflected and enters pulse-counter detector, so just can realize the double mode detection of analog pulse, improve the detection dynamic range of instrument.
Above-mentioned embodiment should not be construed as limiting the scope of the invention.Key of the present invention is: adopt dual-detector setting, in the situation that not needing to change electrode and detecting device polarity, can realize the detection of opposed polarity ion; Also can when changing polarity of electrode, realize the detection that same polarity ion adopts different mode, greatly shorten the switching time of opposed polarity ion detection.In the situation that not departing from spirit of the present invention, within any type of change that the present invention is made all should fall into protection scope of the present invention.
Claims (9)
1. a chromatograph-mass spectrometer pick-up unit, comprise electrode and detecting device, it is characterized in that: described electrode is two plate electrodes staggered relatively, described detecting device is two detecting devices that are arranged on after described two plate electrodes, and ion deflects and enters corresponding detecting device under the electric field action between two plate electrodes.
2. chromatograph-mass spectrometer pick-up unit according to claim 1, is characterized in that: described two detecting devices apply respectively the voltage of opposite polarity, so that the ion of opposed polarity enters corresponding detecting device after the electric deflection between two plate electrodes.
3. chromatograph-mass spectrometer pick-up unit according to claim 1, is characterized in that: the placement that is parallel to each other of described two plate electrodes.
4. chromatograph-mass spectrometer pick-up unit according to claim 1, is characterized in that: described electrode is square-shaped electrode or cylindrical electrode.
5. chromatograph-mass spectrometer pick-up unit according to claim 1, is characterized in that: described two plate electrodes are identical.
6. chromatograph-mass spectrometer pick-up unit according to claim 1, is characterized in that: described two detecting devices are arranged on the perpendicular bisector both sides of described two place, plate electrode center line segments.
7. chromatograph-mass spectrometer pick-up unit according to claim 1, is characterized in that: described two detecting devices are oppositely arranged.
8. chromatograph-mass spectrometer pick-up unit according to claim 1, is characterized in that: described ion enters the electric field between described two plate electrodes along the perpendicular bisector of described two place, plate electrode center line segments.
9. chromatograph-mass spectrometer pick-up unit according to claim 1, is characterized in that: one of them is simulation count detector for described two detecting devices, and another is pulse-counter detector.
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| CN201410140485.4A CN103954699A (en) | 2014-04-01 | 2014-04-01 | Detection device for gas chromatograph-mass spectrometer |
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| CN201410140485.4A CN103954699A (en) | 2014-04-01 | 2014-04-01 | Detection device for gas chromatograph-mass spectrometer |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105719942A (en) * | 2014-12-05 | 2016-06-29 | 中国科学院大连化学物理研究所 | High dynamic range detector for flight time mass spectrum |
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| CN102103973A (en) * | 2009-12-18 | 2011-06-22 | 中国科学院大连化学物理研究所 | Bipolar ion migration tube |
| CN203870076U (en) * | 2014-04-01 | 2014-10-08 | 聚光科技(杭州)股份有限公司 | Detection device for chromatography mass spectrometry instrument |
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2014
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Patent Citations (5)
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| JPS56143649A (en) * | 1980-04-10 | 1981-11-09 | Jeol Ltd | Mass spectrograph |
| CN1152126A (en) * | 1995-04-28 | 1997-06-18 | 株式会社岛津制作所 | Mass spectrometric apparatus for use with liquid chromatograph |
| CN101118833A (en) * | 2007-09-29 | 2008-02-06 | 宁波大学 | Four prismoids shaped four-grade mass spectrometer |
| CN102103973A (en) * | 2009-12-18 | 2011-06-22 | 中国科学院大连化学物理研究所 | Bipolar ion migration tube |
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Non-Patent Citations (1)
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| 李灵峰 等: "双电离源（辉光放电／激光溅射电离）四极杆质谱仪的研制", 《分析化学研究快报》, vol. 40, no. 7, 31 July 2012 (2012-07-31) * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105719942A (en) * | 2014-12-05 | 2016-06-29 | 中国科学院大连化学物理研究所 | High dynamic range detector for flight time mass spectrum |
| CN105719942B (en) * | 2014-12-05 | 2017-12-26 | 中国科学院大连化学物理研究所 | A kind of HDR detector for flight time mass spectrum |
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Application publication date: 20140730 |